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3.
Emerg Infect Dis ; 26(11): 2549-2554, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32956612

RESUMO

In many settings, the ongoing coronavirus disease (COVID-19) pandemic coincides with other major public health threats, in particular tuberculosis. Using tuberculosis (TB) molecular diagnostic infrastructure, which has substantially expanded worldwide in recent years, for COVID-19 case-finding might be warranted. We analyze the potential of using TB diagnostic and research infrastructures for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing. We focused on quality control by adapting the 12 Quality System Essentials framework to the COVID-19 and TB context. We conclude that diagnostic infrastructures for TB can in principle be leveraged to scale-up SARS-CoV-2 testing, in particular in resource-poor settings. TB research infrastructures also can support sequencing of SARS-CoV-2 to study virus evolution and diversity globally. However, fundamental principles of quality management must be followed for both TB and SARS-CoV-2 testing to ensure valid results and to minimize biosafety hazards, and the continuity of TB diagnostic services must be guaranteed at all times.


Assuntos
Betacoronavirus , Técnicas de Laboratório Clínico/normas , Infecções por Coronavirus/diagnóstico , Laboratórios/organização & administração , Pneumonia Viral/diagnóstico , Tuberculose/diagnóstico , Fortalecimento Institucional , Infecções por Coronavirus/epidemiologia , Humanos , Pandemias , Pneumonia Viral/epidemiologia , Controle de Qualidade , Tuberculose/epidemiologia
4.
Sheng Wu Gong Cheng Xue Bao ; 36(7): 1459-1464, 2020 Jul 25.
Artigo em Chinês | MEDLINE | ID: mdl-32748604

RESUMO

The teaching laboratory is the central place to teach lab courses to undergraduate students. It is thus critical to evaluate how lab skills of students will be affected by the management of this lab. This study attempts to introduce the 6S concept, referring to "Seiri", "Seiton", "Seiso", "Seiketsu", "Shisuke", and "Safety", to the management of teaching laboratory, in particular, to the management of environments, safety, item deposition, reagents and consumables in the laboratory. We find that applying the "6S" management maintains a tidy lab environment, facilitates teaching the lab skills, and improves the quality of teaching, which together achieves the goal of education with the atmosphere. This study can provide a guideline for establishing and managing teaching laboratories in universities.


Assuntos
Educação , Laboratórios , Universidades , Educação/organização & administração , Educação/normas , Planejamento Ambiental , Humanos , Laboratórios/organização & administração , Laboratórios/normas , Estudantes , Universidades/organização & administração , Universidades/normas
5.
Artigo em Russo | MEDLINE | ID: mdl-32827381

RESUMO

The analysis of various needs in medical laboratory services among physicians of the Samara oblast is targeted to further improvement of laboratory service at oblast level. It is established that effectiveness of laboratory service depends on the needs of customer of service sector which are both physicians and patients. Ignoring their needs results in an increasing both of number of unsatisfied customers and level of mistrust individual operators and laboratory service itself. On the contrary, client-centric approach facilitates dialog of all participants of process of providing laboratory services.


Assuntos
Laboratórios/organização & administração , Laboratórios/normas , Médicos , Humanos , Federação Russa
9.
Health Secur ; 18(3): 232-236, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32522074

RESUMO

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen that causes coronavirus disease 2019 (COVID-19), which was first detected in Wuhan, China. Recent studies have updated the epidemiologic and clinical characteristics of COVID-19 continuously. In China, diagnostic tests and laboratory tests of specimens from persons under investigation are usually performed in a biosafety level 2 environment. Laboratory staff may be at greater risk of exposure due to a higher concentration and invasiveness of emerging pathogens. Current infection prevention strategies are based on lessons learned from severe acute respiratory syndrome, expert judgments, and related regulations. This article summarizes biosafety prevention and control measures performed in severe acute respiratory syndrome coronavirus 2 testing activities and provides practical suggestions for laboratory staff to avoid laboratory-acquired infections in dealing with public health emergencies.


Assuntos
Técnicas de Laboratório Clínico/métodos , Contenção de Riscos Biológicos/métodos , Infecções por Coronavirus/sangue , Infecção Laboratorial/prevenção & controle , Equipamento de Proteção Individual/estatística & dados numéricos , Pneumonia Viral/sangue , Betacoronavirus , China , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/epidemiologia , Desinfecção/organização & administração , Feminino , Humanos , Laboratórios/organização & administração , Masculino , Saúde do Trabalhador , Pandemias , Pneumonia Viral/epidemiologia , Manejo de Espécimes/métodos
11.
Cytometry A ; 97(9): 882-886, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32583531

RESUMO

Operating shared resource laboratories (SRLs) in times of pandemic is a challenge for research institutions. In a multiuser, high-turnover working space, the transmission of infectious agents is difficult to control. To address this challenge, imaging core facility managers being members of German BioImaging discussed how shared microscopes could be operated with minimal risk of spreading SARS-CoV-2 between users and staff. Here, we describe the resulting guidelines and explain their rationale, with a focus on separating users in space and time, protective face masks, and keeping surfaces virus-free. These recommendations may prove useful for other types of SRLs. © 2020 The Authors. Cytometry Part A published by Wiley Periodicals LLC. on behalf of International Society for Advancement of Cytometry.


Assuntos
Betacoronavirus/patogenicidade , Pesquisa Biomédica/organização & administração , Infecções por Coronavirus/prevenção & controle , Controle de Infecções , Laboratórios/organização & administração , Microscopia , Saúde do Trabalhador , Pandemias/prevenção & controle , Pneumonia Viral/prevenção & controle , Comportamento Cooperativo , Infecções por Coronavirus/transmissão , Infecções por Coronavirus/virologia , Descontaminação , Contaminação de Equipamentos/prevenção & controle , Alemanha , Humanos , Exposição Ocupacional/prevenção & controle , Equipamento de Proteção Individual , Pneumonia Viral/transmissão , Pneumonia Viral/virologia , Fatores de Proteção , Pesquisadores/organização & administração , Medição de Risco , Fatores de Risco , Distância Social , Fluxo de Trabalho
15.
Emerg Infect Dis ; 26(8): 1944-1946, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32433015
16.
Indian J Med Res ; 151(2 & 3): 172-176, 2020.
Artigo em Inglês | MEDLINE | ID: covidwho-30910

RESUMO

Novel coronavirus infection [coronavirus disease 2019 (COVID-19)] has spread to more than 203 countries of various regions including Africa, America, Europe, South East Asia and Western Pacific. The WHO had declared COVID-19 as the global public health emergency and subsequently as pandemic because of its worldwide spread. It is now one of the top-priority pathogens to be dealt with, because of high transmissibility, severe illness and associated mortality, wide geographical spread, lack of control measures with knowledge gaps in veterinary and human epidemiology, immunity and pathogenesis. The quick detection of cases and isolating them has become critical to contain it. To meet the increasing demand of the diagnostic services, it is necessary to enhance and expand laboratory capabilities since existing laboratories cannot meet the emerging demand. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a BSL-2 (Biosafety Level 2) agent and needs to be handled in biosafety cabinet using standard precautions. This review highlights minimum requirements for the diagnostic laboratories opting testing of material for the diagnosis of COVID-19 and associated biorisk to the individuals and to the community.


Assuntos
Contenção de Riscos Biológicos/métodos , Infecções por Coronavirus/diagnóstico , Laboratórios/organização & administração , Pneumonia Viral/diagnóstico , Betacoronavirus , Técnicas de Laboratório Clínico , Humanos , Pandemias , Medição de Risco
17.
Int J Lab Hematol ; 42 Suppl 1: 11-18, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: covidwho-602630

RESUMO

The ongoing COVID-19 pandemic originated in Wuhan, Hubei Province, China, in December 2019. The etiologic agent is a novel coronavirus of presumed zoonotic origin with structural similarity to the viruses responsible for severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). Like SARS and MERS, COVID-19 infection manifests most frequently with lower respiratory symptoms. A minority of patients progress to acute respiratory distress syndrome/ diffuse alveolar damage. In addition to its central role in the diagnosis of COVID-19 infection, the clinical laboratory provides critical information to clinicians regarding prognosis, disease course, and response to therapy. The purpose of this review is to (a) provide background context about the origins and course of the pandemic, (b) discuss the laboratory's role in the diagnosis of COVID-19 infection, (c) summarize the current state of biomarker analysis in COVID-19 infection, with an emphasis on markers derived from the hematology laboratory, (d) comment on the impact of COVID-19 on hematology laboratory safety, and (e) describe the impact the pandemic has had on organized national and international educational activities worldwide.


Assuntos
Betacoronavirus/isolamento & purificação , Serviços de Laboratório Clínico/organização & administração , Infecções por Coronavirus/epidemiologia , Linfopenia/epidemiologia , Pandemias , Pneumonia Viral/epidemiologia , Trombocitopenia/epidemiologia , Anticorpos Antivirais/sangue , Betacoronavirus/patogenicidade , Biomarcadores/sangue , Proteína C-Reativa/metabolismo , China/epidemiologia , Técnicas de Laboratório Clínico/métodos , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/fisiopatologia , Infecções por Coronavirus/transmissão , Hematologia/métodos , Humanos , Incidência , Itália/epidemiologia , Laboratórios/organização & administração , Linfopenia/diagnóstico , Linfopenia/fisiopatologia , Equipamento de Proteção Individual/provisão & distribução , Pneumonia Viral/diagnóstico , Pneumonia Viral/fisiopatologia , Pneumonia Viral/transmissão , Pró-Calcitonina/sangue , Distância Social , Trombocitopenia/diagnóstico , Trombocitopenia/fisiopatologia , Estados Unidos/epidemiologia , Proteínas Virais/sangue
19.
Int J Lab Hematol ; 42 Suppl 1: 11-18, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: covidwho-88478

RESUMO

The ongoing COVID-19 pandemic originated in Wuhan, Hubei Province, China, in December 2019. The etiologic agent is a novel coronavirus of presumed zoonotic origin with structural similarity to the viruses responsible for severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). Like SARS and MERS, COVID-19 infection manifests most frequently with lower respiratory symptoms. A minority of patients progress to acute respiratory distress syndrome/ diffuse alveolar damage. In addition to its central role in the diagnosis of COVID-19 infection, the clinical laboratory provides critical information to clinicians regarding prognosis, disease course, and response to therapy. The purpose of this review is to (a) provide background context about the origins and course of the pandemic, (b) discuss the laboratory's role in the diagnosis of COVID-19 infection, (c) summarize the current state of biomarker analysis in COVID-19 infection, with an emphasis on markers derived from the hematology laboratory, (d) comment on the impact of COVID-19 on hematology laboratory safety, and (e) describe the impact the pandemic has had on organized national and international educational activities worldwide.


Assuntos
Betacoronavirus/isolamento & purificação , Serviços de Laboratório Clínico/organização & administração , Infecções por Coronavirus/epidemiologia , Linfopenia/epidemiologia , Pandemias , Pneumonia Viral/epidemiologia , Trombocitopenia/epidemiologia , Anticorpos Antivirais/sangue , Betacoronavirus/patogenicidade , Biomarcadores/sangue , Proteína C-Reativa/metabolismo , China/epidemiologia , Técnicas de Laboratório Clínico/métodos , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/fisiopatologia , Infecções por Coronavirus/transmissão , Hematologia/métodos , Humanos , Incidência , Itália/epidemiologia , Laboratórios/organização & administração , Linfopenia/diagnóstico , Linfopenia/fisiopatologia , Equipamento de Proteção Individual/provisão & distribução , Pneumonia Viral/diagnóstico , Pneumonia Viral/fisiopatologia , Pneumonia Viral/transmissão , Pró-Calcitonina/sangue , Distância Social , Trombocitopenia/diagnóstico , Trombocitopenia/fisiopatologia , Estados Unidos/epidemiologia , Proteínas Virais/sangue
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