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1.
Medicine (Baltimore) ; 99(16): e19583, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32311925

RESUMO

INTRODUCTION: Hypertension (systemic arterial hypertension [SAH]) is a systemic condition that affects about 30% of the world population, according to data from the World Health Organization (WHO). Drugs used to control this disease have the potential to induce xerostomia, an oral condition in which the decrease of the salivary flow is observed and whose presence leads to the increase of the index of caries, periodontal disease, loss of the teeth, dysgeusia, difficulty of mastication, dysphagia, bad breath and oral burning and impairment of prothesis installed in the buccal cavity, including retention of removable and total dentures. METHODS: This is a randomized, placebo-controlled, blind clinical protocol that aims to analyze the impact of phobiomodulation (PBM) on salivary glands of patients with antihypertensive drug induced xerostomia. Patients will be divided into 2 groups: G1: older adults with xerostomia induced by antihypertensive drugs and treatment with PBM (n = 30); G2: placebo PBM (n = 30). The irradiation will be made using a diode laser emitting at 808 nm with 100 mW and 40 seconds of exposure per site at the salivary glands. Twenty sites will be irradiated weekly for 4 weeks. Non-stimulated and stimulated salivary flow will be analyzed before and after the treatment. RESULTS: This protocol will determine the effectiveness of photodynamic therapy regarding the reduction of xerostomia in older adults using antihypertensive drugs. CONCLUSION: This protocol will determine the effectiveness of photodynamic therapy regarding the reduction of xerostomia in older adults using antihypertensive drugs. TRIAL REGISTRATION: Clinicaltrials.gov - NCT03632096.


Assuntos
Anti-Hipertensivos/efeitos adversos , Lasers Semicondutores/uso terapêutico , Terapia com Luz de Baixa Intensidade , Salivação/efeitos da radiação , Xerostomia/metabolismo , Xerostomia/radioterapia , Método Duplo-Cego , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Saliva/metabolismo , Xerostomia/induzido quimicamente
2.
Niger J Clin Pract ; 23(2): 165-171, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32031090

RESUMO

Aims: The aim of this study is to evaluate the effect of the diode laser used for dentin sensitivity on the clinical success of non-carious cervical lesion (NCCL) restorations restored with different adhesive systems. Methods: 20 NCCLs were restorated with Universal Single Bond (Self Etch) (3M, USA) and Grandio (Voco, Germany), 20 NCCLs were restorated with Universal Single Bond (Total Etch) and Grandio. After diode laser application, 20 NCCLs were restorated with Universal Single Bond and Grandio, 20 NCCLs were restorated with Universal Single Bond (Total Etch) and Grandio. The restorations were clinical evaluated by two examiners at baseline, for 6 and 18 months using modified United States Public Health Service (USPHS) Criteria. Chi-square test was used for statistical analyse. Results: The lowest rates of retention was found in the Group 1. There was no statistically significant difference among the groups in marginal discoloration, marginal integrity, sensitivity (P > 0.05). Conclusion: Diode laser application prior to the restoration of teeth with NCCL don't reduce the retention rate of restorations, may reduce hypersensitivity and may affect the success of restoration. However, further laboratory and clinical studies are required.


Assuntos
Adesivos/farmacologia , Resinas Compostas , Corrosão Dentária , Restauração Dentária Permanente/métodos , Lasers Semicondutores/uso terapêutico , Colo do Dente , Adulto , Bis-Fenol A-Glicidil Metacrilato , Adaptação Marginal Dentária , Sensibilidade da Dentina , Adesivos Dentinários , Feminino , Seguimentos , Humanos , Lasers Semicondutores/efeitos adversos , Masculino , Pessoa de Meia-Idade
3.
Oral Dis ; 25(8): 1954-1963, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31478283

RESUMO

OBJECTIVE: In this study, the effect of photodynamic therapy with topical corticosteroid in oral lichen planus patients was compared. MATERIAL AND METHODS: In this randomized, double-blind clinical trial, eight patients with bilateral oral OLP lesions were recruited. Toluidine blue was applied on the lesions of both sides; a 660-nm diode laser InGaAlP was irradiated for 10 min (power: 25 mW, fluence: 19.23 J/cm2 , probe cross section: 0.78 cm2 ) for three sessions. In the control side of the oral mucosa, only sham laser was used. Follow-up sessions were held on weeks 3 and 7. In week 3, oral paste triamcinolone acetonide 0.1% was prescribed. Response rates were assessed clinically by VAS, Thongprasom sign scoring, clinical severity index, efficacy indices, and the amount of reduction in the size of the lesions. The Mann-Whitney test was used to evaluate the treatment outcomes. RESULTS: In spite of the control side, all scores improved significantly between sessions 0 and 4 for the intervention side. The differences between the changes in almost all scores between sessions 0 and 4 in both the intervention and control sides were significantly considerable (p value < .05). CONCLUSION: Photodynamic therapy can be used as an alternative therapy alongside standard methods or as a new modality for refractory OLP.


Assuntos
Corticosteroides/uso terapêutico , Líquen Plano Bucal/terapia , Terapia com Luz de Baixa Intensidade/métodos , Fotoquimioterapia/métodos , Fármacos Fotossensibilizantes/uso terapêutico , Cloreto de Tolônio/uso terapêutico , Administração Tópica , Corticosteroides/administração & dosagem , Método Duplo-Cego , Feminino , Humanos , Lasers Semicondutores/uso terapêutico , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
4.
Braz Oral Res ; 33: e084, 2019 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-31460610

RESUMO

This study aimed to evaluate the role of photobiomodulation (PBM) in apexification and apexogenesis of necrotic rat molars with an open apex. Rat molars were exposed to the oral environment for 3 weeks. Canals were rinsed with 2.5% NaOCl and 17% EDTA, filled with antibiotic paste and sealed. After 7 days, canals were rinsed and divided into six groups (n=6): mineral trioxide aggregate (MTA); blood clot (BC); human dental pulp stem cells (hDPSC); MTA+PBM; BC+PBM; and hDPSC+PBM. In hDPSC groups, a 1% agarose gel scaffold was used. Two groups were not exposed: healthy tooth+PBM (n = 6), healthy tooth (n = 3); and one was exposed throughout the experiment: necrotic tooth (n = 3). In PBM groups, irradiation was performed with aluminum gallium indium phosphide (InGaAlP) diode laser for 30 days within 24-h intervals. After that, the specimens were processed for histological and immunohistochemical analyses. Necrotic tooth showed greater neutrophil infiltrate (p < 0.05). Necrotic tooth, healthy tooth, and healthy tooth+PBM groups showed absence of a thin layer of fibrous condensation in the periapical area. All the other groups stimulated the formation of a thicker layer of fibers (p < 0.05). All groups formed more mineralized tissue than necrotic tooth (p < 0.05). PBM associated with MTA, BC, or hDPSC formed more mineralized tissue (p < 0.05). MTA+PBM induced apexification (p < 0.05). Rabbit polyclonal anti-bone sialoprotein (BSP) antibody confirmed the histological findings of mineralized tissue formation, and hDPSC groups exhibited higher percentage of BSP-positive cells. It can be concluded that PBM improved apexification and favored apexogenesis in necrotic rat molars with an open apex.


Assuntos
Apexificação/métodos , Cavidade Pulpar/efeitos da radiação , Necrose da Polpa Dentária/radioterapia , Lasers Semicondutores/uso terapêutico , Terapia com Luz de Baixa Intensidade/métodos , Ápice Dentário/efeitos da radiação , Doenças Dentárias/radioterapia , Compostos de Alumínio/uso terapêutico , Animais , Compostos de Cálcio/uso terapêutico , Polpa Dentária/citologia , Cavidade Pulpar/patologia , Necrose da Polpa Dentária/patologia , Combinação de Medicamentos , Imuno-Histoquímica , Sialoproteína de Ligação à Integrina/análise , Óxidos/uso terapêutico , Distribuição Aleatória , Ratos Wistar , Reprodutibilidade dos Testes , Silicatos/uso terapêutico , Células-Tronco , Ápice Dentário/patologia , Doenças Dentárias/patologia , Resultado do Tratamento
5.
Arch Pediatr ; 26(5): 268-274, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31281038

RESUMO

Photobiomodulation is recommended in adults for the prevention of mucositis induced by cervicofacial irradiation or pre-transplant chemotherapy. The results of pediatric studies are promising but this support treatment is still underused. The objective was to conduct a feasibility study in the pediatric hematology-oncology unit at X Children's Hospital. Extra- and intraoral scans were performed a minimum of three times every 2 days for grade 2 or higher mucositis in children (median age, 8.6 years) using the Oncolase laser (Biophoton, Saint Alban, France), with a combination of two wavelengths (635 and 815nm). The effect of the laser on mucositis grade, pain, the child's tolerance, and the time dedicated to this care were also evaluated. The success of the procedure was 77% in 1 year, with the inclusion of 84% of the patients (n=22) and 146 laser treatment sessions (median of four per episode of mucositis). We observed excellent tolerance and pain relief with a gain of two points on the VAS and the HEDEN mucositis scale. This study shows that photobiomodulation that incorporates two application modes (intra- and extraoral) through the combination of two wavelengths is feasible when integrated into the care of a pediatric hematology-oncology department and is perfectly tolerated, even by young children. Along with oral hygiene and analgesic management, it alleviates pain associated with oral mucositis.


Assuntos
Lasers Semicondutores/uso terapêutico , Terapia com Luz de Baixa Intensidade/métodos , Estomatite/radioterapia , Adolescente , Criança , Pré-Escolar , Estudos de Viabilidade , Feminino , Seguimentos , Humanos , Masculino , Estudos Prospectivos , Resultado do Tratamento
6.
Lasers Med Sci ; 34(9): 1735-1746, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31309364

RESUMO

In recent years, extensive evidence has been published about usage of laser in oral lesions. The aim of the present study was to review the effectiveness of laser radiation in the treatment of pediatric oral soft tissue problems. The relevant keywords were searched in EBSCO, Medline (via Ovid), PubMed, Scopus, and Web of Science (WOS) databases. Then, eligible case series and controlled clinical trial studies, which published up to the end of 2018, were extracted and scrutinized. In this study, the age range of ≤ 21 years or the average age of ≤ 21 years was considered as the pediatric group. After limiting the search results, removing duplicate titles and eligibility evaluation, 17 papers were enrolled to the study (seven controlled clinical trials and ten case series). Er:YAG (2940 nm), CO2 (10,600 nm), Er,Cr:YSGG (2780 nm), and diode (650, 660, and 975 nm) lasers indicated successful clinical results on mucocele excision, frenectomy, gingival incision and re-contouring, and treatment of vascular malformations. In addition, 660-nm diode laser radiation was an effective adjuvant treatment for halitosis and gingivitis induced by multi-bracket appliances. Reduction or absence of pain and bleeding, suitable homeostasis, reduction of operation time, less analgesic consumption, and antibacterial effect were among the advantages of the laser radiation in the studies. Laser as a main or adjuvant tool can have an effective role in surgical and non-surgical treatments of pediatric oral soft tissue problems. Conducting further randomized controlled trial studies on different soft tissue lesions can contribute to drawing better conclusions.


Assuntos
Terapia a Laser , Boca/patologia , Boca/efeitos da radiação , Criança , Humanos , Lasers Semicondutores/uso terapêutico , Viés de Publicação , Risco , Resultado do Tratamento
7.
Photobiomodul Photomed Laser Surg ; 37(5): 276-281, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31084563

RESUMO

Objective: The aim of this study was to determine if a single photobiomodulation treatment can reduce oral erythema and edema following routine dental prophylaxis in canines. Background: Photobiomodulation therapy has been documented to accelerate healing time through mitigation of erythema and edema in human and veterinary patients. Methods: Canine patients were randomly assigned into three groups: CG (Control, n = 9, mock gingiva treatment without irradiation), LTG (left side treated, n = 8, irradiation of left upper and lower dental arcade), and RTG (right side treated, n = 7, irradiation of right upper and lower dental arcade). Immediately following anesthetized dental prophylaxis, the canines in the RTG and LTG received four points of irradiation (GaAlInP-650 nm, continuous wave, 0.1 W, 0.2 W/cm2, 100 sec, 10 J, 20 J/cm2). Erythema and edema along the gingival surface of each dental arcade were scored 24 h after treatment by a blinded veterinary evaluator. Analysis of variance and Bonferroni correction were used for data analysis. Results: Using a composite evaluation, there was significantly lower inflammation scores for the RTG (p = 0.017) and LTG (p = 0.025) relative to the CG at the location of the lower right dental arcade. Evaluating erythema individually, a significant reduction was found in the LTG (p = 0.049) when compared with the CG for the lower left dental arcade. Conclusions: Despite the limitations in this study, the canines who received a single photobiomodulation treatment demonstrated some degree of reduction in oral inflammation and erythema following dental prophylaxis.


Assuntos
Profilaxia Dentária/efeitos adversos , Edema/terapia , Eritema/terapia , Lasers Semicondutores/uso terapêutico , Terapia com Luz de Baixa Intensidade , Doenças Periodontais/terapia , Animais , Cães , Edema/etiologia , Eritema/etiologia , Feminino , Gengiva , Masculino
8.
Photodiagnosis Photodyn Ther ; 27: 111-116, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31146012

RESUMO

BACKGROUND: The aim of the current systematic review was to evaluate the efficacy of phototherapy in the adhesive bonding of different dental posts to root dentin. METHODS: The outline of this systematic review followed the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. Searches in both electronic and manual literature were performed in the main databases 'MEDLINE' and 'EMBASE' up to March 2019 using the following terms: (Phototherapy) AND (push out test) AND (bond strength) AND (post) OR (fibre) OR (metal) AND (smear layer). RESULTS: Six in-vitro studies were included and processed for data extraction. All studies incorporated the use of fiber posts. The mean shear bond strength for test group ranged from 2.23 to 15.17 MPa while mean shear bond strength for control group ranged from 2.93 to 9.38 MPa. The wavelengths of diode lasers ranged from 660 to 2940 nm (nm). Power was reported in 5 studies ranging from 0.075 W to 3 W. All studies compared shear bond strength of phototherapy in the adhesive bonding of different dental posts to root dentin. In all the included studies, greater bond strength achieved by phototherapy compared to nonirradiated group. CONCLUSION: Within the limits, this study shows that the dentin to post bond strength was significantly enhanced by phototherapy.


Assuntos
Cimentos Dentários , Implantes Dentários , Dentina/metabolismo , Lasers Semicondutores/uso terapêutico , Terapia com Luz de Baixa Intensidade/métodos , Técnicas In Vitro
9.
Indian J Ophthalmol ; 67(6): 962-964, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31124533

RESUMO

Oculocutaneous albinism is characterized by partial or complete absence of melanin in retinal pigment epithelium (RPE) and uveal melanocytes. Absence of typical fundal background from RPE and choroid makes it difficult to diagnose retinal disorders in ocular albinism. Lack of melanin in RPE makes the laser photocoagulation very challenging in these cases. This report presents a unique case of preterm infant of oculocutaneous albinism diagnosed as aggressive posterior retinopathy of prematurity (APROP), which was successfully treated with diode laser photocoagulation. The parameters of the laser used in this case were higher than usual, just enough to achieve blanching of retina. This report highlights the fact that the diagnosis of APROP and its treatment with laser is challenging in the presence of oculocutaneous albinism, but it is possible to achieve complete regression using diode laser at higher parameters.


Assuntos
Albinismo Ocular/diagnóstico , Fotocoagulação a Laser/métodos , Lasers Semicondutores/uso terapêutico , Retina/patologia , Retinopatia da Prematuridade/cirurgia , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Oftalmoscopia/métodos , Retina/cirurgia , Retinopatia da Prematuridade/diagnóstico
10.
Photobiomodul Photomed Laser Surg ; 37(2): 85-90, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31050927

RESUMO

Objective: The aim of this randomized clinical trial was to evaluate the influence of root canal disinfection with a 940-nm diode laser on the intensity of pain after endodontic retreatment. Background data: Microorganisms are the most common causes of tooth pain. Therefore, clinical studies are needed to explore the effect of disinfection techniques on postoperative pain. Methods: Eighty-four patients scheduled for endodontic retreatment were allocated to two groups in a 1:1 ratio (n = 42 each). After root canal filling removal and chemomechanical procedures, the root canals were disinfected with a 940-nm diode laser in one group [laser disinfection (LD) group]. In the other group, a mock application of laser was made with the power off [pseudo-laser disinfection (PLD) group]. All retreatment procedures were completed in a single visit. The patients assessed their pain levels at 24, 48, and 72 h after retreatment using a numeric rating scale. The number of analgesic pills used during this period was also recorded. The collected data were statistically analyzed using Mann-Whitney U and Wilcoxon tests. Results: Postoperative pain on the first 2 days was significantly lesser in the LD group than in the PLD group (p < 0.05), and the difference became insignificant on the third day (p > 0.05). Moreover, analgesic intake over 3 days and pain on percussion on the fourth day were significantly lesser in the LD group than in the PLD group (p < 0.05). Conclusions: Elimination of microorganisms from root canals is important for preventing postoperative complications. Our findings suggest that diode LD can reduce postoperative pain and provide comfort after endodontic retreatment. This study is registered in www.ClinicalTrials.gov database with the identifier number NCT03584880.


Assuntos
Lasers Semicondutores/uso terapêutico , Terapia com Luz de Baixa Intensidade/instrumentação , Dor Pós-Operatória/prevenção & controle , Obturação do Canal Radicular/efeitos adversos , Preparo de Canal Radicular/instrumentação , Adolescente , Adulto , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Dor Pós-Operatória/diagnóstico , Dor Pós-Operatória/etiologia , Adulto Jovem
11.
Photobiomodul Photomed Laser Surg ; 37(2): 117-123, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31050930

RESUMO

Objective: A single-blind randomized clinical trial was conducted to evaluate the effectiveness of desensitizing agents with different action mechanisms in reducing cervical dentin hypersensitivity (CDH) after four application sessions, with 24-week follow-up. Materials and methods: Sixty patients with CDH were selected in the study and were allocated in three groups of treatment: Desensibilize KF 2%, Clinpro XT Varnish, and Photon Lase III (100 mW, 4 J/cm2-1 J/cm2 each point, 10 sec per point with wavelength of 808 nm). There were four application sessions performed, with a 48-h interval between each one. The evaporative stimuli and visual analog scale were used to evaluate the CDH level at baseline, immediately after treatment, and at 2, 4, 8, and 24 weeks after the application. Mixed-model effects test was used for comparison (α = 0.05).Results: All three groups showed significant reduction in CDH from baseline to each all-subsequent follow-up. All the groups maintained the CDH reduction, and presented no statistical differences between each other after treatment (p = 0.885), 2 (p = 0.857), 4 (p = 0.928), 8 (p = 0.206), and 24 weeks (p = 0.073) of follow-up.Conclusions: The four-session protocol was an effective approach in reduction of CDH (even after 24 weeks), regardless of desensitization mechanism.


Assuntos
Dessensibilizantes Dentinários/uso terapêutico , Sensibilidade da Dentina/terapia , Lasers Semicondutores/uso terapêutico , Terapia com Luz de Baixa Intensidade , Adolescente , Adulto , Protocolos Clínicos , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Método Simples-Cego , Resultado do Tratamento , Adulto Jovem
12.
Photobiomodul Photomed Laser Surg ; 37(2): 91-98, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31050932

RESUMO

Objective: This study aimed to compare the efficacy of diode laser surgery and the scalpel surgery in the removal of inflammatory fibrous hyperplasia (IFH). Background data: Diode laser systems are proposed as an alternative to scalpel surgery on surgeries involving oral soft tissues. Some of the advantages of the laser systems are ease of application, adequate coagulation, reduced postoperative pain, and decreased scarring. In addition, there are increasing data on the antibacterial effects of the diode lasers in dentistry; however, the direct bactericidal role of the diode laser in oral soft tissue procedures has not yet been investigated. Materials and methods: A total of 22 patients were enrolled in this study. One side of IFH was randomly assigned for excision with scalpel blade or with diode laser. Perioperative bleeding, postoperative pain, wound healing, and bacterial counts were evaluated for both methods. Results: The bleeding on the side treated by diode laser was found significantly lower (p < 0.05). A notable reduction in total bacterial counts was observed in the laser group after the first postoperative day. However, this trend did not reach statistical significance. No significant differences were recorded regarding subjective postoperative pain between the groups (p = 0.065). The healing of the postoperative wounds was significantly faster in the conventional group at each time point. Conclusions: Diode laser has offered some advantages over conventional method in the management of IFH. However, large-cohort comparative studies are required to provide additional data regarding the wound healing capacity of the diode laser.


Assuntos
Terapia a Laser , Lasers Semicondutores/uso terapêutico , Boca/patologia , Boca/cirurgia , Procedimentos Cirúrgicos Bucais/instrumentação , Dor Pós-Operatória/epidemiologia , Adulto , Idoso , Feminino , Fibrose/patologia , Fibrose/cirurgia , Humanos , Hiperplasia/patologia , Hiperplasia/cirurgia , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento , Cicatrização
13.
Photobiomodul Photomed Laser Surg ; 37(2): 99-109, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31050933

RESUMO

Background: Mechanical methods of periodontal therapy alone may fail to eliminate the tissue-invasive pathogenic flora; therefore, considerable attention has been given to adjunctive antimicrobial measures. Objective: The aim of this study was to investigate and compare the clinical and microbiological effects of diode laser (DL) as an adjunct to Kirkland flap surgery versus Kirkland flap surgery alone for the treatment of generalized chronic periodontitis. Materials and methods: A total of 20 patients with generalized chronic periodontitis with probing pocket depth ≥5 mm after phase I therapy were included in this split-mouth study. Two contralateral quadrants of each patient were randomly assigned to either test or control group. Control group was treated with Kirkland flap surgery alone, whereas test group was treated with DL as an adjunct to Kirkland flap surgery. Periodontal parameters were recorded, and subgingival plaque samples were collected from both the control and test groups at baseline and third and sixth month. The plaque samples were then analyzed for red complex organisms using quantitative real-time polymerase chain reaction. Results: Compared with baseline, both treatments showed an improvement in periodontal parameters at the third and sixth month. However, test group produced a significant improvement in plaque index (1.039 ± 0.069 vs. 1.392 ± 0.17, p < 0.001), bleeding on probing (16.512 ± 5.982 vs. 37.051 ± 7.459, p < 0.001), probing pocket depth (1.727 ± 0.39 vs. 3.016 ± 0.47, p < 0.001), and clinical attachment level (2.054 ± 0.524 vs. 3.354 ± 0.728, p < 0.001) at third and sixth month compared with the control group. Moreover, in the test group, levels of red complex bacteria were significantly reduced at third and sixth month compared with the control group. Conclusions: DL as an adjunct to Kirkland flap surgery has resulted in a greater reduction in clinical and microbiological parameters compared with Kirkland flap surgery alone, thereby offering additional benefit in treating generalized chronic periodontitis patients.


Assuntos
Periodontite Crônica/cirurgia , Lasers Semicondutores/uso terapêutico , Procedimentos Cirúrgicos Bucais/instrumentação , Bolsa Periodontal/cirurgia , Retalhos Cirúrgicos , Adulto , Periodontite Crônica/complicações , Periodontite Crônica/microbiologia , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Bolsa Periodontal/complicações , Bolsa Periodontal/microbiologia , Resultado do Tratamento
14.
Photobiomodul Photomed Laser Surg ; 37(1): 57-61, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31050937

RESUMO

Objective: To describe a clinical case of successful conservative management of Localized Juvenile Spongiotic Gingivitis Hyperplasia (LJSGH) using photodynamic therapy (PDT) and reviews the current literature on this pathology. Background data: LJSGH is a recently described rare disease with controversial treatment results. As of today, 13 publications report surgical treatment approaches. The use of CO2 laser and cryotherapy was reported only in one study. The use of PDT was not previously reported. Patients and methods: A 9-year-old male patient was referred to our institution with the chief complaint of asymptomatic "inflamed gingiva" starting 1 year before. Clinical examination revealed an erythematous line accompanying the gingival contour, with a certain degree of hyperplasia. The diagnosis of LJSGH was performed based on clinical features and later confirmed histopathologically. A novel approach using PDT was then proposed. The photosensitizer was methylene blue, and a semiconductor laser diode was used. Results: One week after starting PDT, gingival hyperplasia was partially reduced. Immediately after the end of treatment, a significant reduction of gingival hyperplasia was observed. PDT proved to be safe, quick and painless, with no esthetic harm. Conclusions: This case illustrates the benefit of a more conservative approach as opposed to surgical procedure, with good clinical response and decreased morbidity over a 2-year follow-up period.


Assuntos
Hiperplasia Gengival/tratamento farmacológico , Fotoquimioterapia/métodos , Criança , Humanos , Lasers Semicondutores/uso terapêutico , Masculino , Azul de Metileno/uso terapêutico , Fármacos Fotossensibilizantes/uso terapêutico
15.
Photobiomodul Photomed Laser Surg ; 37(1): 25-30, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31050941

RESUMO

Objective: Our study aimed to detect whether 450 nm blue laser can be applied effectively and safely in endosocopic submucosal dissection (ESD) system for surgery in colonic tissue. Background data: Semiconductor blue laser has been applied in surgery due to its excellent cutting property, however, whether blue laser can be applied in colonic surgery has not been reported. Materials and methods: Porcine colon tissues were vaporized by 450 nm blue semiconductor laser at 10-25 W and at working distances from 0.5 to 3 mm, with a three-dimensional scanning system. Moreover, we designed an ESD model and applied blue laser at 10 W on porcine colonic tissues with this system. Dimensions of the vaporized tissues and coagulation zones were assessed under microscopy. Results: Since the thickness of colonic wall is no more than 1 mm, first we determined the cutting property and safety of blue laser on porcine colon tissue and found that blue laser at 10 W made lesions shallower than 1 mm and the depth of vaporization can be controlled effectively within muscularis mucosa and submucosa. Moreover, a large scale of porcine colonic tissue was vaporized precisely by blue laser at power of 10 W with the ESD system ex vivo. Conclusions: Our results indicate that 450 nm blue laser at 10 W can be well controlled for laser-tissue interaction with excellent cutting efficiency and less thermal damage in adjacent tissues especially side of the submucosa. Therefore, 450 nm semiconductor blue laser could be a safe alternative approach for colonic surgery.


Assuntos
Colo/cirurgia , Ressecção Endoscópica de Mucosa/instrumentação , Lasers Semicondutores/uso terapêutico , Animais , Desenho de Equipamento , Técnicas In Vitro , Suínos
17.
J Cosmet Dermatol ; 18(3): 773-777, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31116009

RESUMO

INTRODUCTION: Visible leg veins are a common cosmetic concern treated mostly by 1064 nm Nd:YAG laser that has become the chosen laser therapy for treating all leg veins up to 3 mm in size. The objective of the current prospective study was to evaluate the safety and efficacy of a new 1064 nm diode laser for leg veins and spider veins on the lower extremities. METHODS: A total of 15 female subjects seeking leg veins and spider veins treatment were recruited to this study. The treatment protocol included two treatment sessions 6 weeks apart and two follow-up visits at three and 6 months after the last diode laser treatment. Results were evaluated by photographs and an investigator classification of the treated vascular lesions appearance on five scores scale from 0 (normal) to 4 (severe). RESULTS: Treatment area photos demonstrated improvement in vascular lesions appearance. Average vascular lesions classification was reduced by approximately one score from baseline score of 2.9 (score 3 is moderate) to an average score 2 (mild) at the 3-month follow-up visit. This improved classification sustained also at 6-month follow-up visit, indicating the long-term effect of the treatment impact. No significant or unexpected adverse events were detected in any of the patients as a result of the treatments. CONCLUSIONS: This study has demonstrated that the new 1064 nm diode laser is safe and effective for the treatment of leg vascular lesions on the lower extremities.


Assuntos
Terapia a Laser/instrumentação , Lasers Semicondutores/uso terapêutico , Telangiectasia/cirurgia , Adulto , Feminino , Humanos , Terapia a Laser/efeitos adversos , Terapia a Laser/métodos , Perna (Membro) , Extremidade Inferior , Pessoa de Meia-Idade , Estudos Prospectivos , Resultado do Tratamento
18.
Photodiagnosis Photodyn Ther ; 27: 66-73, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31100446

RESUMO

BACKGROUND: Antimicrobial photodynamic therapy (aPDT) shows antimicrobial activity on yeast of the genus Candida. In aPDT, the depth at which the light penetrates the tissue is extremely important for the elaboration of the treatment. The aim of this study was to evaluate the action of aPDT on experimental candidiasis and the laser impact in the tissue using Galleria mellonella as the infection model. METHODS: G. mellonella larvae were infected with different Candida albicans strains. After 30 min, they were treated with methylene blue-mediated aPDT and a low intensity laser (660 nm). The larvae were incubated at 37 °C for seven days and monitored daily to determine the survival curve, using the Log-rank test (Mantel Cox). To evaluate the distribution of the laser as well as its depth of action in the larva body, the Interactive 3D surface PLOT of Image J was used. The effects of aPDT on the immune system were also evaluated by the quantification of hemocytes in the hemolymph of G. mellonella after 6 h of Candida infection (ANOVA and Tukey's test). RESULTS: In both the ATCC 18,804 strain and the C. albicans clinical strain 17, aPDT prolonged the survival of the infected G. mellonella larvae by a lethal fungal dose. There was a statistically significant difference between the aPDT and the control groups in the ATCC strain (P = 0.0056). The depth of laser action in the insect body without the photosensitizer was 2.5 mm and 2.4 mm from the cuticle of the larva with the photosensitizer. In the larvae, a uniform distribution of light occurred along 32% of the body length for the group without the photosensitizer and in 39.5% for the group with the photosensitizer. In the immunological analysis, the infection by C. albicans ATCC 18,804 in G. mellonella led to a reduction in the number of hemocytes in the hemolymph. The aPDT and laser treatment induced a slight increase in the number of hemocytes. CONCLUSION: Both aPDT and laser treatment positively influenced the treatment of experimental candidiasis. G. mellonella larvae were a useful model for the study of light tissue penetration in antimicrobial photodynamic therapy.


Assuntos
Candidíase/tratamento farmacológico , Azul de Metileno/farmacologia , Mariposas/efeitos dos fármacos , Fotoquimioterapia/métodos , Fármacos Fotossensibilizantes/farmacologia , Animais , Candida albicans/efeitos dos fármacos , Modelos Animais de Doenças , Larva , Lasers Semicondutores/uso terapêutico
20.
Rev. ADM ; 76(2): 109-112, mar.-abr. 2019. ilus
Artigo em Espanhol | LILACS | ID: biblio-1009264

RESUMO

La desprogramación neuromuscular juega un papel importante en el tratamiento de la disfunción temporomandibular, uno de los principales inconvenientes es el periodo prolongado del tratamiento, lo cual influye en la aceptación del paciente o el abandono del tratamiento. El diagnóstico es crucial para planificar el tratamiento ya que cubre una amplia gama de variables para tratarlo, por lo que en este caso es un paciente dolicofacial, con problemas de disfunción temporomandibular de origen muscular, por lo cual se optó por utilizar laserterapia de bajo nivel como coadyuvante de tratamiento, dando como resultado una mejor aceptación y colaboración de la desprogramación del paciente en un periodo de tiempo más corto (AU)


Neuromuscular deprogramming plays an important role in the treatment of temporomandibular dysfunction, one of the main drawbacks is the prolonged period of treatment, which influences the acceptance of the patient or the abandonment of treatment. The diagnosis is crucial to plan the treatment since it covers a wide range of variables to treat it, so in this case it is a dolichofacial patient, with problems of temporomandibular dysfunction of muscular origin, which is why we chose to use low-level laser therapy, level as a coadjutant of treatment, resulting in a better acceptance and collaboration of the deprogramming of the patient in a shorter period of time (AU)


Assuntos
Humanos , Masculino , Adolescente , Síndrome da Disfunção da Articulação Temporomandibular/terapia , Oclusão Dentária Central , Lasers Semicondutores/uso terapêutico , Placas Oclusais , Articuladores Dentários , México
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