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1.
J Refract Surg ; 37(9): 623-630, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34506244

RESUMO

PURPOSE: To compare the clinical and tomographic properties of adult patients with keratoconus treated with accelerated corneal cross-linking (A-CXL) versus accelerated contact lens-assisted corneal cross-linking (A-CACXL). METHODS: Patients who underwent A-CXL and A-CACXL due to progressive keratoconus were enrolled from January 2015 to January 2018 in this retrospective case-control study. The treatment group (minimum corneal thickness of less than 400 µm after epithelium removal; 30 patients, 30 eyes) was treated with A-CACXL; the control group (minimum corneal thickness of 400 µm or greater, 32 patients, 32 eyes) was treated with A-CXL. Assessments occurred before treatment and 12 months postoperatively. Demographic, clinical, and tomographic data were obtained from outpatient clinic reports. RESULTS: Significant improvement in visual acuity was evident at 12-month follow-up for the control group in uncorrected distance visual acuity (0.62 ± 0.42 vs 0.43 ± 0.31 logMAR, P = .01) and the treatment group in corrected distance visual acuity (0.51 ± 0.30 vs 0.40 ± 0.49 logMAR, P = .03). Progression of keratoconus was halted at similar rates for both groups (76.7% treatment, 84.4% control, P = .21). Mean minimum corneal thickness showed minor but significant thinning at the 12-month follow-up visit compared to baseline (control group = 463 ± 31 vs 450 ± 35 µm, P > .01; treatment group = 398 ± 32 vs 388 ± 41 µm, P = .02). CONCLUSIONS: A-CACXL halted keratoconus progression in 76.7% of eyes and achieved regression in 33.3% of eyes, with rates comparable to A-CXL. Visual outcomes improved for both groups, with similar keratometry changes. A-CACXL is an effective and safe option for patients with keratoconus and thin corneas, with results similar to A-CXL treatment in patients with a minimum corneal thickness of 400 µm or greater. [J Refract Surg. 2021;37(9):623-630.].


Assuntos
Lentes de Contato , Ceratocone , Fotoquimioterapia , Adulto , Estudos de Casos e Controles , Colágeno/uso terapêutico , Topografia da Córnea , Reagentes para Ligações Cruzadas/uso terapêutico , Seguimentos , Humanos , Ceratocone/tratamento farmacológico , Fármacos Fotossensibilizantes/uso terapêutico , Estudos Retrospectivos , Riboflavina/uso terapêutico , Raios Ultravioleta
2.
Eye Contact Lens ; 47(10): 575-577, 2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-34469372

RESUMO

ABSTRACT: This case series examines the magnitude and regional variation in scleral lens-induced corneal edema in postradial keratotomy (RK) eyes. Scheimpflug imaging was used to measure corneal thickness across the central 6 mm before and after scleral lens wear in nine post-RK eyes (median age 64 years). Variations in corneal edema were examined as a function of distance from the corneal center (six 0.5-mm annuli) and from 0° to 360°. The median central corneal edema was 2.19% (interquartile range 1.03%-3.18%; P=0.02) and increased in magnitude and variability further from the central cornea (from 1.30% in the central 0-0.5 mm to 3.12% in the 2.5-3.0 mm midperiphery) (P=0.02). Scleral lens-induced corneal edema in post-RK eyes was greater in magnitude further from the corneal center and at the approximate location of corneal incisions.


Assuntos
Lentes de Contato , Edema da Córnea , Ceratotomia Radial , Córnea , Edema da Córnea/diagnóstico , Edema da Córnea/etiologia , Humanos , Ceratotomia Radial/efeitos adversos , Pessoa de Meia-Idade , Esclera
3.
Niger J Clin Pract ; 24(9): 1350-1359, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34531349

RESUMO

Aims: The aim of this study was to explore adolescents' (11-20 years) usage of, beliefs in, attitudes toward, and barriers to contact lens use in Riyadh, Saudi Arabia. Method: The study recruited 1252 healthy participants from 20 highly populated schools. The schools were selected at random from middle and high schools in Riyadh. A self-administered contact lens questionnaire was used directed towards glasses usage and contact lens knowledge, usage, attitudes, and barriers. Result: A total of 726 of the 1252 participants had refractive errors, and 47% of those wore glasses. The proportion of non-compliance was 24%. One of the main reasons of non-compliance was cosmetic appearance (26%). Fewer than 10% were offered contact lenses for refractive error correction. One hundred and fifty-nine participants used contact lenses, and most obtained them without proper professional consultation. About 90% of contact lens-wearing participants did not sleep with the lenses and about 50% had no complications wearing them. Conclusion: The percentage of contact lens users was relatively low. A substantial number of older adolescents and females were found to wear contact lenses, although without proper professional consultation. Knowledge of and attitudes toward contact lenses among adolescents were in acceptable levels. These results gave indications that contact lens usage in adolescents can be achievable and valuable for refractive error correction, especially for those who are non-compliant with glasses.


Assuntos
Lentes de Contato , Erros de Refração , Adolescente , Criança , Feminino , Humanos , Masculino , Satisfação do Paciente , Erros de Refração/epidemiologia , Erros de Refração/terapia , Arábia Saudita , Inquéritos e Questionários , Adulto Jovem
4.
Eye Contact Lens ; 47(10): 552-554, 2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-34542423

RESUMO

OBJECTIVES: To evaluate the perilimbal vasculature of patients who wear contact lenses (CLs) overnight with optical coherence tomography angiography (OCTA) and compare the results with healthy population. METHODS: Forty-two patients were included in this observational study. The OCTA imaging was performed in the temporal quadrant of the perilimbal region using a swept-source optical coherence tomography system (Triton DRI-OCT; Topcon Corporation, Tokyo, Japan). The assessments were made in two depths: starting from the conjunctival epithelium to 200 µm scleral depth and the scleral depth between 200 and 1,000 µm. The vessel density, vessel length density, vessel diameter index, and fractal dimension were the main outcomes and compared between overnight CL users and healthy population. RESULTS: Twenty-two patients who have been using CLs overnight for at least 3 months and 20 healthy individuals were included in the study. The vessel density at the superficial layer was significantly higher in the CL group compared with the control group (P<0.001). Vessel diameter index, vessel length density, and fractal dimension at the superficial layer did not differ between the groups (P>0.05 for all). There was no difference in the vessel density, vessel diameter index, vessel length density, and fractal dimension in the deep layer between the groups (P>0.05 for all). CONCLUSIONS: Patients who use CL overnight exhibit increased vessel density in the superficial layers of the perilimbal region, which may suggest new vessel formation in the conjunctiva. Anterior segment OCTA may be useful to evaluate the initial changes in limbal vasculature in CL users.


Assuntos
Lentes de Contato , Tomografia de Coerência Óptica , Túnica Conjuntiva/diagnóstico por imagem , Angiofluoresceinografia , Humanos , Esclera
5.
BMC Ophthalmol ; 21(1): 325, 2021 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-34493240

RESUMO

BACKGROUND: Designing educational interventions tailored to the needs of Contact Lens Wearers (CLWs) are important and necessary. The present study aimed to determine the information needs of CLWs to educate and provide information to them to increase their knowledge and reduce complications and non-compliance behaviors. METHODS: A qualitative approach was applied and semi-structured interviews were conducted in three contact lenses (CL) clinics in Iran among all their practitioners and 24 purposively selected patients. Data were analyzed using the Lundman and Graneheim conventional content analysis. RESULTS: The qualitative analysis revealed knowledge and skill themes as two main categories. The knowledge category includes five subcategories of basic information for the CLWs, acquaintance with the CL, caring for CL, hygiene and vigilance of CL, and challenges of using CL. The skill category consists of two subcategories, including handling/insertion and removal of the CL, and stabilization of learned information. Moreover, 36 sub-subcategories emerged from these seven subcategories that reflected the information needs of CLWs. CONCLUSIONS: A clear understanding of CLWs' information needs can help to design and develop appropriate educational approaches to overcome training barriers such as physicians' time constraints and high workload. Moreover, it can help deal with CLWs' insufficient knowledge and provide the required information simply and practically with the possibility of enough repetition.


Assuntos
Lentes de Contato , Escolaridade , Humanos , Higiene , Cooperação do Paciente , Pesquisa Qualitativa
6.
Int J Mol Sci ; 22(15)2021 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-34360731

RESUMO

This work demonstrates the detections and mappings of a solid object using a thermally tunable solid-state phononic crystal lens at low frequency for potential use in future long-distance detection. The phononic crystal lens is infiltrated with a polyvinyl alcohol-based poly n-isopropyl acrylamide (PVA-PNIPAm) bulk hydrogel polymer. The hydrogel undergoes a volumetric phase transition due to a temperature change leading to a temperature-dependent sound velocity and density. The temperature variation from 20 °C to 39 °C changes the focal length of the tunable solid-state lens by 1 cm in the axial direction. This thermo-reversible tunable focal length lens was used in a monostatic setup for one- and two-dimensional mapping scans in both frequency domain echo-intensity and temporal domain time-of-flight modes. The experimental results illustrated 1.03 ± 0.15λ and 2.35 ± 0.28λ on the lateral and axial minimum detectable object size. The experiments using the tunable lens demonstrate the capability to detect objects by changing the temperature in water without translating an object, source, or detector. The time-of-flight mode modality using the tunable solid-state phononic lens increases the signal-to-noise ratio compared to a conventional phononic crystal lens.


Assuntos
Resinas Acrílicas/química , Lentes de Contato , Hidrogéis/química , Álcool de Polivinil/química , Ultrassonografia
7.
Zhonghua Yan Ke Za Zhi ; 57(8): 573-579, 2021 Aug 11.
Artigo em Chinês | MEDLINE | ID: mdl-34344117

RESUMO

The number of contact lens wearers is ever-growing in China. In order to promote the safety of wearing contact lenses, the Society of Contact Lens Safety Monitoring & Vision Health of Chinese Health Association has conducted extensive discussions on the diagnosis and treatment of adverse reactions of contact lens wear, including the definition, classification, contact lens-related inducements, and therapeutic principles and methods, on the basis of referencing relevant literature and summarizing clinical practice experience, combined with the opinions of experts from relevant professional groups of the Ophthalmology Branch of the Chinese Medical Association. After repeated letter reviews and revisions, this expert consensus is formed for the reference and use of optometry practitioners and clinicians. (Chin J Ophthalmol, 2021, 57: 573-579).


Assuntos
Lentes de Contato , Oftalmologia , Optometria , China , Consenso , Lentes de Contato/efeitos adversos , Humanos
8.
Molecules ; 26(16)2021 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-34443612

RESUMO

Eucalyptus leaves (ELE) and willow bark (WBE) extracts were utilized towards the formation of silver nanoparticles (AgNPs(ELE), AgNPs(WBE)). AgNPs(ELE) and AgNPs(WBE) were dispersed in polymer hydrogels to create pHEMA@AgNPs(ELE)_2 and pHEMA@AgNPs(WBE)_2 using hydroxyethyl-methacrylate (HEMA). The materials were characterized in a solid state by X-ray fluorescence (XRF) spectroscopy, X-ray powder diffraction analysis (XRPD), thermogravimetric differential thermal analysis (TG-DTA), differential scanning calorimetry (DTG/DSC) and attenuated total reflection spectroscopy (ATR-FTIR) and ultraviolet visible (UV-vis) spectroscopy in solution. The antimicrobial potential of the materials was investigated against the Gram-negative bacterial strain Pseudomonas aeruginosa (P. aeruginosa) and the Gram-positive bacterial strain of the genus Staphylococcus epidermidis (S. epidermidis) and Staphylococcus aureus (S. aureus), which are involved in microbial keratitis. The percentage of bacterial viability of P. aeruginosa and S. epidermidis upon their incubation over the pHEMA@AgNPs(ELE)_2 discs is interestingly low (28.3 and 6.8% respectively), while the inhibition zones (IZ) formed are 12.3 ± 1.7 and 13.2 ± 1.2 mm, respectively. No in vitro toxicity of this material towards human corneal epithelial cells (HCEC) was detected. Despite its low performance against S. aureus, pHEMA@AgNPs(ELE)_2 could be an efficient candidate towards the development of contact lenses that reduces microbial infection risk.


Assuntos
Lentes de Contato/microbiologia , Eucalyptus/química , Hidrogéis/química , Extratos Vegetais/química , Salix/química , Prata/farmacologia , Antibacterianos/síntese química , Antibacterianos/química , Antibacterianos/farmacologia , Humanos , Nanopartículas Metálicas , Testes de Sensibilidade Microbiana , Prata/química
10.
Vestn Oftalmol ; 137(4): 90-97, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34410062

RESUMO

Optical correction of keratoconus (KC) is intended to simultaneously solve two tasks: elimination of myopic defocus and irregular astigmatism. In terms of the latter, hard contact lenses (HCL) should be considered as the first-choice method for optical correction of KC. HCL are currently the most effective means of optical correction of refractive errors induced by KC. Despite this, it should be noted that adherence of patients to this method of correction does not always correspond to results. Most often, limitations of HCL use in KC are associated with the so-called intolerance of correction. The term «correction intolerance¼ should be considered as a general complex of potential subjective symptoms and clinical manifestations that limit the possibility of using a particular method of optical correction. In this clinical observation, subjective discomfort when wearing lenses was practically eliminated by changing the design of the lens and switching from corneal to scleral HCL. The second problem was caused by clinical manifestations of corneal hypoxia (growth of newly formed vessels in the limbal region of the cornea) and attempts to solve it were associated with improved tear production and increased oxygen permeability of the material HCL are made of. The observed stabilization of the growth of newly formed vessels should be considered as a positive (although in need of dynamic evaluation) result of these therapeutic measures.


Assuntos
Astigmatismo , Lentes de Contato , Ceratocone , Erros de Refração , Lentes de Contato/efeitos adversos , Córnea , Humanos , Ceratocone/diagnóstico , Ceratocone/etiologia , Ceratocone/terapia
11.
Eye Contact Lens ; 47(9): 515-519, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34424225

RESUMO

OBJECTIVES: To assess dry eye symptoms associated with different contact lens modalities in patients with keratoconus using a dry eye questionnaire. METHODS: An online survey was distributed by the National Keratoconus Foundation. The survey asked participants to report demographic characteristics, current optical correction, age at the time of diagnosis of keratoconus, and contact lens history. The 12-item Ocular Surface Disease Index (OSDI) questionnaire was also completed. Data from participants wearing the same contact lens modality bilaterally were analyzed. RESULTS: The survey was completed by 197 individuals wearing the same contact lens modality bilaterally. The average age of participants at the time of the survey was 47.2±14.8 years (range: 15-87 years), and the average age at which keratoconus was diagnosed was 26.1±9.9 years (range: 8-55 years). The mean overall OSDI score of all participants was 40.2±22.8 (range: 0-100). There was no difference in the mean OSDI scores based on current contact lens modality type (F=1.79; n=187; P=0.13). Based on an OSDI score of 33 or higher, 90% of participants reported symptoms indicative of dry eye disease. Scleral lens wearers reported less discomfort on the individual items related to windy and low-humidity conditions. CONCLUSIONS: Individuals with keratoconus, irrespective of contact lens modality, report a high incidence of dry eye symptoms.


Assuntos
Lentes de Contato , Síndromes do Olho Seco , Ceratocone , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Lentes de Contato/efeitos adversos , Síndromes do Olho Seco/epidemiologia , Síndromes do Olho Seco/etiologia , Humanos , Ceratocone/terapia , Pessoa de Meia-Idade , Esclera , Inquéritos e Questionários , Adulto Jovem
13.
Clin Exp Optom ; 104(6): 684-690, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34233585

RESUMO

CLINICAL RELEVANCE: Examination of the literature can help answer the age-old question of the extent to which rigid contact lenses can be considered an art versus a science. BACKGROUND: This work aims to assemble rigid contact lens-related publication metrics to identify the most impactful papers, authors, institutions, countries and journals. METHODS: A search was undertaken of the Scopus database to identify rigid contact lens-related articles published since this lens type was first described in 1949. The 25 most highly cited papers were determined from the total list of 1,823 papers found. Rank-order lists by count were assembled for the 'top 25' in each of four categories: authors, institutions, countries and journals. A subject-specific rigid contact lens h-index (hRL-index) was derived for each author, institution, country and journal to serve as a measure of impact in the field. A short list of the top constituents in each category were ranked by hRL-index and tabulated. RESULTS: The most highly cited paper (467 citations) is entitled 'Risk factors and prognosis for corneal ectasia after LASIK', by Randleman et al. Karla Zadnik (hRL = 20; 32 papers) and Richard Hill (h = 10; 50 papers) are most impactful and prolific authors, respectively. The Ohio State University (hRL = 24; 96 papers) is the most impactful and prolific institution and the United States (hRL = 51; 680 papers) is the most impactful and prolific country. Optometry and Vision Science (hRL = 30; 233 papers) is the most impactful journal. CONCLUSIONS: Impactful authors, institutions, countries and journals in the field of rigid lenses are identified. Although there is perhaps an artistic element to rigid contact lens fitting, the solid literature base underpinning the field of rigid contact lenses revealed here belies the notion that rigid lenses fitting is more of an art than a science.


Assuntos
Lentes de Contato , Doenças da Córnea , Ceratomileuse Assistida por Excimer Laser In Situ , Optometria , Bibliometria , Humanos , Estados Unidos
14.
Arq Bras Oftalmol ; 84(5): 462-466, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34320106

RESUMO

PURPOSE: Microcornea is a rare condition that frequently resulets in serious cosmetic concerns due to the resultant asymmetrical appearance of the eye, and its cosmetic rehabilitation is possible with the use of colored contact lenses. This paper aims to present our experiences with the use of cosmetic Etafilcon A contact lenses for microcornea. METHODS: Eight patients with unilateral microcornea without any systemic involvement were included in this study, and they underwent routine ophthalmological examination, corneal topography, and optical biometry. We applied the cosmetic Etafilcon A contact lens (1-DAY ACUVUE® DEFINE® with Lacreon®) of the same edge color to the patients. The levels of satisfaction in terms of cosmesis and comfort were evaluated with the use of visual analog scales (VAS). RESULTS: In the patients, the corneal diameter asymmetry was acceptably adjusted, and each of the patients reported extreme satisfaction. The mean VAS score was 8.9 ± 1.0 (range: 7-10) for the cosmetic satisfaction rate and 8.4 ± 1.0 (range: 7-10) for the comfort rate. The patients obtained the best-corrected visual acuity without or with additional eye-glasses. None of the patients complained about vision issues under photopic and scotopic conditions. CONCLUSION: 1-DAY ACUVUE® DEFINE® with Lacreon® lens has promising satisfactory cosmetic outcomes along with visual enhancement in cases of microcornea. This is the first study to report the use of this lens for the cosmetic rehabilitation of patients with microcornea.


Assuntos
Lentes de Contato Hidrofílicas , Lentes de Contato , Topografia da Córnea , Humanos , Metacrilatos , Procedimentos Cirúrgicos Oftalmológicos
15.
Arq Bras Oftalmol ; 84(5): 474-480, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34320109

RESUMO

PURPOSE: The aim of this study was to analyze patient data and the laboratory results of corneal samples collected from patients followed at the Ophthalmology Department, Hospital São Paulo, Brazil over a 30-year period, and correlate the analize with contact lens wearing. METHODS: Corneal samples from patients diagnosed clinically with microbial keratitis between January 1987 and December 2016 were included in this study. Cultures that were positive for bacteria, fungi, and Acanthamoeba spp. were analyzed retrospectively. To ascertain if the number of patients with contact-lens-associated microbial keratitis (as a risk factor for microbial infection) changed over time, the analysis was divided into three decades: 1987-1996, 1997-2006, and 2007-2016. Information pertaining to patient gender and age, as well as type of organism isolated, were compared among these periods. RESULTS: The corneal samples of 10.562 patients with a clinical diagnosis of microbial keratitis were included in the study, among which 1.848 cases were related to the use of contact lenses. The results revealed that the frequency of contact-lens-associated microbial keratitis increased over the last two decades. Overall, females had contact-lens-associated microbial keratitis more frequently (59.5%). Patients aged 19-40 years also had contact-lens-associated microbial keratitis more frequently in all study periods. Staphylococcus spp. and Pseudomonas spp. were the most frequent Gram-positive and Gram-negative bacteria, respectively, in the microbial keratitis groups. Among the fungal cases of microbial keratitis, filamentous fungi were the most frequent fungi over the entire study period, with Fusarium spp. being the most frequent fungi in the group with microbial keratitis not associated with contact lens wearing (p<0.001). Samples positive for Acanthamoeba spp. and Pseudomonas spp. were significantly correlated with contact-lens-associated microbial keratitis (p<0.001). CONCLUSIONS: Females and young adults aged 19-40 years exhibited the highest frequency of contact-lens-associated microbial keratitis in our study. Staphylococcus spp. and Fusarium spp. were the predominant bacteria and fungi, respectively, isolated from corneal samples. Pseudomonas spp. and Acanthamoeba spp. were significantly correlated with contact-lens-associated microbial keratitis in this study.


Assuntos
Lentes de Contato , Ceratite , Antibacterianos , Brasil/epidemiologia , Lentes de Contato/efeitos adversos , Feminino , Bactérias Gram-Negativas , Bactérias Gram-Positivas , Hospitais , Humanos , Ceratite/epidemiologia , Encaminhamento e Consulta , Estudos Retrospectivos , Adulto Jovem
16.
Colloids Surf B Biointerfaces ; 206: 111957, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34216853

RESUMO

Silicone hydrogel lenses were prepared by copolymerizing PDMS-PEGMA macromer (PGP) with various combinations of DMA, NVP, and PEGMA through UV initiated polymerization process. The resultant PGP macromer were characterized by gel permeation chromatography (GPC), and scanning electron microscope (SEM-EDS). Characterization of all the resultant co-polymers included Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), equilibrium water content (EWC), oxygen permeability (Dk), optical transparency, contact angle, mechanical properties, zeta potential, protein deposition, and cytotoxicity. The results show that higher content of hydrophilic polymers increased water uptake ability as well as improved hydrophilicity and modulus of silicone hydrogel lenses; however, oxygen permeability decreased with the decrease of PDMS content (145 barrers of PGP to 37 barrers of DP0). In addition, these silicone hydrogel lenses exhibited relatively optical transparency, anti-protein deposition, and non-cytotoxic according to an in vitro L929 fibroblast assay. Therefore, these silicone hydrogel polymers would be applicable for making contact lens.


Assuntos
Lentes de Contato Hidrofílicas , Lentes de Contato , Dimetilpolisiloxanos , Hidrogel de Polietilenoglicol-Dimetacrilato , Hidrogéis , Interações Hidrofóbicas e Hidrofílicas , Polímeros , Silicones
17.
Eye Contact Lens ; 47(9): 520-525, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34261868

RESUMO

OBJECTIVES: To assess the quality-of-life improvement after scleral lens fitting in patients with keratoconus. METHODS: We conducted a prospective observational study of all consecutive patients with keratoconus starting scleral lens fitting in 2019, from January 2 to December 27, at the Dijon University Hospital, France. Quality of life was assessed before and after wearing scleral lenses for 3 months through the National Eye Institute Visual Function Questionnaire 25 (NEI-VFQ 25) questionnaire. We investigated factors potentially influencing quality of life: final visual acuity, keratoconus stage, and maximum keratometry reading. RESULTS: In total, 41 eyes of 24 patients were successfully fitted with scleral lenses, 92.9% were 18 mm in diameter and 7.1% were 17 mm. The visual acuity improved by -0.4±0.3 logarithm of the minimum angle of resolution (P<0.001) after scleral lens fitting. Visual gain increased with keratometry and keratoconus severity (P<0.001; P<0.01). The NEI-VFQ 25 score increased by 19.5±19.1 points on average (P<0.001). No association was found between the factors under study and improvement in quality of life. CONCLUSION: Our study confirms the functional improvement in patients with keratoconus fitted with scleral lenses, especially in patients with more advanced disease. Moreover, it suggests a major role of these lenses in improving quality of life, independently of the severity of the disease and the visual gain.


Assuntos
Lentes de Contato , Ceratocone , Humanos , Ceratocone/terapia , Ajuste de Prótese , Qualidade de Vida , Estudos Retrospectivos , Esclera
18.
Biosensors (Basel) ; 11(6)2021 Jun 09.
Artigo em Inglês | MEDLINE | ID: mdl-34207533

RESUMO

Diabetes mellitus (DM) is a chronic disease that must be carefully managed to prevent serious complications such as cardiovascular disease, retinopathy, nephropathy and neuropathy. Self-monitoring of blood glucose is a crucial tool for managing diabetes and, at present, all relevant procedures are invasive while they only provide periodic measurements. The pain and measurement intermittency associated with invasive techniques resulted in the exploration of painless, continuous, and non-invasive techniques of glucose measurement that would facilitate intensive management. The focus of this review paper is the existing solutions for continuous non-invasive glucose monitoring via contact lenses (CLs) and to carry out a detailed, qualitative, and comparative analysis to inform prospective researchers on viable pathways. Direct glucose monitoring via CLs is contingent on the detection of biomarkers present in the lacrimal fluid. In this review, emphasis is given on two types of sensors: a graphene-AgNW hybrid sensor and an amperometric sensor. Both sensors can detect the presence of glucose in the lacrimal fluid by using the enzyme, glucose oxidase. Additionally, this review covers fabrication procedures for CL biosensors. Ever since Google published the first glucose monitoring embedded system on a CL, CL biosensors have been considered state-of-the-art in the medical device research and development industry. The CL not only has to have a sensory system, it must also have an embedded integrated circuit (IC) for readout and wireless communication. Moreover, to retain mobility and ease of use of the CLs used for continuous glucose monitoring, the power supply to the solid-state IC on such CLs must be wireless. Currently, there are four methods of powering CLs: utilizing solar energy, via a biofuel cell, or by inductive or radiofrequency (RF) power. Although, there are many limitations associated with each method, the limitations common to all, are safety restrictions and CL size limitations. Bearing this in mind, RF power has received most of the attention in reported literature, whereas solar power has received the least attention in the literature. CLs seem a very promising target for cutting edge biotechnological applications of diagnostic, prognostic and therapeutic relevance.


Assuntos
Técnicas Biossensoriais , Automonitorização da Glicemia , Glicemia , Lentes de Contato , Diabetes Mellitus , Glucose , Humanos , Estudos Prospectivos
19.
Vestn Oftalmol ; 137(3): 21-25, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34156774

RESUMO

Currently, the number of contact lens users in the world is approximately 10% of the total population of developed countries. Despite the undeniable advantages of contact lenses over eyeglasses, complications are an unpleasant aspect of their use. An analysis of the literature showed that purulent-inflammatory complications have not been fully described. PURPOSE: To study the prevalence of keratitis associated with contact lenses, its clinical manifestations, microbial etiology, and sensitivity to antibiotics. MATERIAL AND METHODS: The study analyzes case histories of 171 patients with infectious keratitis treated at the Children's Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan in 2016-2018. RESULTS: The retrospective analysis revealed an increase in both the number of infectious keratitis and the keratitis associated with contact correction. All patients had a severe course of keratitis with the formation of gross opacity. The leading pathogens were Pseudomonas aeruginosae and Klebsiella oxytoca. The pathogens were not 100% sensitive to any one of the 7 studied antibiotics. The smallest percentage of resistant strains (12.5%) was determined for fluoroquinolones of the 2nd and 3rd generation (ciprofloxacin and levofloxacin), as well as meropenem. CONCLUSION: Considering the number of contact lens users in the world, keratitis associated with contact lenses poses a serious problem.


Assuntos
Lentes de Contato , Infecções Oculares Bacterianas , Ceratite , Infecções por Pseudomonas , Adolescente , Antibacterianos/uso terapêutico , Criança , Lentes de Contato/efeitos adversos , Humanos , Ceratite/diagnóstico , Ceratite/epidemiologia , Ceratite/etiologia , Infecções por Pseudomonas/tratamento farmacológico , Estudos Retrospectivos
20.
Transl Vis Sci Technol ; 10(7): 32, 2021 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-34191016

RESUMO

Purpose: To determine whether Mel4-coated antimicrobial contact lenses (MACLs) can reduce the incidence of corneal infiltrative events (CIEs) during extended wear. Methods: A prospective, randomized, double-masked, single-center, contralateral, extended contact lens wear clinical trial was conducted with 176 subjects. Each participant was randomly assigned to wear a MACL in one eye and an uncoated control contact lens in the contralateral eye or an extended-wear biweekly disposable modality for 3 months. The main outcome measures were the incidence of CIEs per 100 eye-months, identification of the microbial types colonizing the contact lenses or eyes at the time of the CIEs, and their susceptibility to Mel4. Results: Nine participants (5.1%) experienced unilateral CIEs; six participants had contact lens acute red eye, and three participants had infiltrative keratitis. The incidence rate for CIEs (0.4 events per 100 participant months; 1.7%) in the Mel4-coated lenses (test) was 69% less than that of the control lenses (1.3 events per 100 participant months; 3.4%; P = 0.29). All Gram-negative bacteria isolated from lenses and lids of participants with CIEs (Citrobacter diversus, Acinetobacter haemolyticus, and Acinetobacter lwoffii) were susceptible to Mel4 peptide; minimum inhibitory concentrations ranged from 15.6 to 62.5 µg/mL. Reduction of adhesion of these bacteria by Mel4-coated lenses ranged from 2.1 to 2.2 log10 colony-forming units/lens. Conclusions: MACLs had the capacity to reduce CIEs by at least 50% compared with uncoated control lenses during extended wear over 3 months; however, due to the relatively low rates of CIEs, the reduction was not statistically different compared with control lenses. Translational Relevance: This study provides evidence that antimicrobial contact lenses have the potential to reduce the incidence of corneal infiltrative events during extended wear.


Assuntos
Lentes de Contato , Acinetobacter , Antibacterianos , Humanos , Estudos Prospectivos
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