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1.
Anticancer Res ; 40(1): 557-564, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31892612

RESUMO

BACKGROUND/AIM: Ultraviolet radiation (UVR) causes solar lentigines (SL) and skin cancer (SC) in humans. The association between measured lifetime UVR dose and SC has not been investigated. This study investigated this relation through their common relationship to SL. MATERIALS AND METHODS: First we investigated the association between lifetime UVR dose and SL for 16,897 days in 38 healthy participants, and secondly, the relation between SL and SC was investigated in 2,898 participants, including 149 with SC. By combining both studies, SC risk related to lifetime UVR dose and skin phototype was estimated. RESULTS: A positive association was found between SL and lifetime UVR dose (p=0.060). Skin phototype (p=0.001) and SL (p<0.001) were associated with SC. Combined SC risk increased 1.23 by doubling the average lifetime UVR dose and was 34.9 times higher for those with very fair skin compared to dark Mediterranean skin. CONCLUSION: The estimate of SC risk shows that skin phototype is of greater relative importance than lifetime UVR dose.


Assuntos
Lentigo/epidemiologia , Neoplasias Cutâneas/epidemiologia , Raios Ultravioleta , Adulto , Idoso , Relação Dose-Resposta à Radiação , Feminino , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Razão de Chances , Fatores de Risco
2.
J Eur Acad Dermatol Venereol ; 33 Suppl 2: 76-88, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30811689

RESUMO

INTRODUCTION: Sunbed use has been significantly associated with increased risk of melanoma and non-melanoma skin cancer (NMSC), but its relationship with melanoma's risk factors such as high nevus count, atypical nevi and lentigines is poorly studied. Euromelanoma is a skin cancer prevention campaign conducted all over Europe. It offers a once-a-year screening during which participants' data, including sunbed use and phenotype, are collected via questionnaires. OBJECTIVES: To investigate the association of sunbed use with nevus count, atypical nevi, lentigines and suspicion of skin cancer. METHODS: To ensure reliability of the data, we defined inclusion and exclusion criteria for countries' eligibility for the risk analysis. Multivariate logistic regression models (including age, gender, education, skin type, family history of melanoma, personal history of skin cancer, any sun exposure and any sunscreen use) were used to calculate summary odds ratios (SORs) of each clinical endpoint for ever sunbed use. RESULTS: Overall, 227 888 individuals from 30 countries completed the Euromelanoma questionnaire. After the data quality check, 16 countries were eligible for the multivariate analysis, for a total of 145 980 participants (64.8% females; median age 43 years; 62.3% highly educated; 28.5% skin type I-II; 11.0% ever sunbed use). Ever sunbed use was independently associated with nevus count >50 [SOR = 1.05 (1.01-1.10)], atypical nevi [SOR = 1.04 (1.00-1.09)], lentigines [SOR = 1.16 (1.04-1.29)] and suspicion of melanoma [SOR = 1.13 (1.00-1.27)]. Conversely, no significant association was found between ever sunbed use and suspicion of NMSC [SOR = 1.00 (0.91-1.10)]. CONCLUSIONS: Indoor tanning is significantly associated with well-recognized risk factors for melanoma (including high nevus count, presence of atypical nevi and lentigines) as well as suspicion of melanoma within the Euromelanoma screenees. In order to reduce the prevalence of melanoma risk factors, avoidance/discontinuation of sunbed use should always be encouraged, especially but not exclusively for individuals with high-risk phenotypes.


Assuntos
Carcinoma Basocelular/epidemiologia , Carcinoma de Células Escamosas/epidemiologia , Lentigo/epidemiologia , Nevo/epidemiologia , Nevo/patologia , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/patologia , Banho de Sol/estatística & dados numéricos , Adulto , Europa (Continente)/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Neoplasias Cutâneas/prevenção & controle , Inquéritos e Questionários , Carga Tumoral
3.
JAMA Dermatol ; 154(7): 789-795, 2018 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-29898205

RESUMO

Importance: Recently, the red hair variants of MC1R were found to contribute differently to pigmentation phenotype in males and females. Objective: To investigate the role of these variants in melanoma risk in males and females separately because carriers of the red hair variants of MC1R are at increased risk of melanoma. Design, Setting, and Participants: In this hospital-based, case-control study, we evaluated the effect of MC1R and melanoma risk for males and females separately by performing multivariate logistic regression analyses. Main Outcomes and Measures: Association of MC1R variants and melanoma risk in males and females. Results: A total of 905 females (473 melanoma cases, 432 controls) and 886 males (518 melanoma cases, 368 controls) were included in the analyses. The mean (SD) age of the study population was 59.2 (15.6). In females, carrying any MC1R red hair variants remained an independent risk factor of melanoma in a multivariable analysis (adjusted odds ratio [OR], 2.19 [95% CI, 1.60-2.99]), whereas in males, only signs of actinic skin damage (lentigines on the back [OR, 2.56; 95% CI, 1.47-4.45; P = .001] and the hands [OR, 2.31; 95% CI, 1.24-4.29; P = .008] and wrinkling on the neck [OR, 2.17; 95% CI, 1.23-3.82; P = .007]) and sunburns (OR, 1.65; 95% CI, 1.12-2.42; P = .01) remained significant risk factors. Conclusions and Relevance: MC1R variants contribute differently to melanoma risk in males and females. This could be helpful to better classify melanoma risk factors between the sexes.


Assuntos
Melanoma/epidemiologia , Melanoma/genética , Receptor Tipo 1 de Melanocortina/genética , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/genética , Adulto , Idoso , Áustria/epidemiologia , Estudos de Casos e Controles , Feminino , Variação Genética , Cor de Cabelo/genética , Humanos , Lentigo/epidemiologia , Masculino , Pessoa de Meia-Idade , Pescoço , Fenótipo , Fatores de Risco , Fatores Sexuais , Envelhecimento da Pele , Pigmentação da Pele/genética , Queimadura Solar/epidemiologia
4.
Ann Saudi Med ; 37(3): 240-244, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28578364

RESUMO

BACKGROUND: Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder caused by defective DNA repair that results in extreme sensitivity to ultraviolet (UV) rays. Depending on the type of XP, the disease may affect the skin, eyes and nervous system. OBJECTIVES: Describe the dermatologic manifestations in patients suffering from XP. DESIGN: Retrospective, descriptive review of medical records. SETTING: Dermatology clinic at tertiary care center in Riyadh. PATIENTS AND METHODS: This study included Saudi patients with clinically confirmed XP. MAIN OUTCOME MEASURE(S): Demographic and clinical data including pathology and associated conditions and outcomes. RESULTS: Of 21 patients with XP, the most common manifestation was lentigines, affecting 18 patients (86%). The most common skin cancer was basal cell carcinoma followed by squamous cell carcinoma (SCC) affecting 15 (71.4%) and 9 (42.8%), respectively. Other skin findings included neurofibroma, trichilemmoma and seborrheic keratosis. Ocular involvement included photophobia, which was the most common finding followed by dryness and ocular malignancies. Two patients showed neurological involvement, which correlated with the type of mutation. CONCLUSION: Considering that XP is a rare genetic disease, this description of our patient population will aid in early recognition and diagnosis. LIMITATIONS: Retrospective and small number of patients. Genetic analyses were done for only 5 of the 21 patients.


Assuntos
Carcinoma Basocelular/epidemiologia , Carcinoma de Células Escamosas/epidemiologia , Neoplasias Cutâneas/epidemiologia , Xeroderma Pigmentoso/patologia , Adolescente , Adulto , Carcinoma Basocelular/patologia , Carcinoma de Células Escamosas/patologia , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Lentigo/epidemiologia , Masculino , Fotofobia/epidemiologia , Fotofobia/etiologia , Estudos Retrospectivos , Arábia Saudita , Neoplasias Cutâneas/patologia , Centros de Atenção Terciária , Xeroderma Pigmentoso/complicações , Xeroderma Pigmentoso/genética , Adulto Jovem
5.
J Eur Acad Dermatol Venereol ; 31(2): 355-360, 2017 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-27593207

RESUMO

BACKGROUND: Skin ageing especially senile lentigo directly affects self-esteem. For decades, senile lentigo has been associated with chronic exposure to solar radiation. However, a study conducted recently in Caucasian subjects suggested that exposure to air pollution was significantly correlated with extrinsic skin ageing, in particular senile lentigines. OBJECTIVE: To investigate the association between fine particulate matter (PM2.5 ) and skin ageing, particularly senile lentigo and seborrheic keratosis. METHODS: The study enrolled 400 Chinese women aged 40-90 years including 210 from the Yanqing county in Beijing (low PM2.5 exposure group) and 190 from the Xuanwumen in Beijing (high PM2.5 exposure group). Skin ageing symptoms, particularly senile lentigines and seborrheic keratoses, were clinically assessed using scores of intrinsic and extrinsic skin ageing. An ordinal logistic regression model was used to analyse the effect of PM2.5 on skin ageing adjusted for factors underlying skin ageing. RESULTS: In the study population of Xuanwumen, we found that senile lentigo on cheeks and back of hands was 1.48 times and 2.8 times higher, respectively, compared with those from Yanqing county. However, no association was found between PM2.5 and seborrheic keratosis. We found that other variables such as smoking, second-hand smoking, contact with fossil fuels and skin types were significantly associated with skin ageing. CONCLUSION: These results indicate that PM2.5 was another extrinsic factor promoting skin ageing.


Assuntos
Lentigo/induzido quimicamente , Material Particulado , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Feminino , Humanos , Lentigo/epidemiologia , Pessoa de Meia-Idade , Envelhecimento da Pele
7.
Cutis ; 97(6): 421-5, 2016 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-27416086

RESUMO

The incidence of cutaneous melanoma (CM) has increased in the last decade. Some risk factors are well known, but there are other possible risk factors being studied, such as those involving nutrition. The objective of this case-control study was to assess the association between diet and CM. Classical risk factors, dietary intake, and body mass index were assessed. Binary logistic regression was used to study the association between dietary intake and the risk for CM. Classical risk factors associated with CM were confirmed. The findings suggest that some foods rich in vitamins A and D and phytochemicals may be related to CM.


Assuntos
Dieta/estatística & dados numéricos , Melanoma/epidemiologia , Compostos Fitoquímicos , Neoplasias Cutâneas/epidemiologia , Vitamina A , Vitamina D , Adulto , Idoso , Brasil/epidemiologia , Estudos de Casos e Controles , Feminino , Frutas , Humanos , Incidência , Ceratose Actínica/epidemiologia , Lentigo/epidemiologia , Modelos Logísticos , Masculino , Melanose/epidemiologia , Pessoa de Meia-Idade , Nevo/epidemiologia , Exposição Ocupacional/estatística & dados numéricos , Fatores de Proteção , Fatores de Risco , Luz Solar , Protetores Solares/uso terapêutico , Verduras
8.
Pigment Cell Melanoma Res ; 29(5): 550-8, 2016 09.
Artigo em Inglês | MEDLINE | ID: mdl-27327535

RESUMO

Solar lentigines are a common feature of sun-induced skin ageing. Little is known, however, about the genetic factors contributing to their development. In this genome-wide association study, we aimed to identify genetic loci associated with solar lentigines on the face in 502 middle-aged French women. Nine SNPs, gathered in two independent blocks on chromosome 6, exhibited a false discovery rate below 25% when looking for associations with the facial lentigine score. The first block, in the 6p22 region, corresponded to intergenic SNPs and also exhibited a significant association with forehead lentigines (P = 1.37 × 10(-8) ). The second block, within the 6p21 HLA region, was associated with decreased HLA-C expression according to several eQTL databases. Interestingly, these SNPs were also in high linkage disequilibrium with the HLA-C*0701 allele (r(2)  = 0.95). We replicated an association recently found by GWAS in the IRF4 gene. Finally, a complementary study on 44 selected candidate SNPs revealed novel associations in the MITF gene. Overall, our results point to several mechanisms involved in the severity of facial lentigines, including HLA/immunity and the melanogenesis pathway.


Assuntos
Estudo de Associação Genômica Ampla , Antígenos HLA/genética , Lentigo/genética , Polimorfismo de Nucleotídeo Único/genética , Envelhecimento da Pele/genética , Luz Solar/efeitos adversos , Biomarcadores/análise , Grupo com Ancestrais do Continente Europeu , Feminino , Loci Gênicos , Predisposição Genética para Doença , Humanos , Lentigo/epidemiologia , Lentigo/patologia , Desequilíbrio de Ligação , Pessoa de Meia-Idade , Envelhecimento da Pele/etnologia , Envelhecimento da Pele/patologia
10.
Actas dermo-sifiliogr. (Ed. impr.) ; 106(4): e19-e22, mayo 2015. ilus
Artigo em Espanhol | IBECS | ID: ibc-138061

RESUMO

El síndrome LEOPARD es una enfermedad autosómica dominante producida por mutaciones germinales en la vía RAS-MAPK. El acrónimo agrupa las manifestaciones más importantes de la enfermedad (Lentiginosis, ECG conduction anomalies, Ocular hypertelorism/hypertrophic Obstructive cardiomyopathy, Pulmonary stenosis, Abnormalities of genitalia, growth Retardation and Deafness), pero ninguna de ellas es patognomónica ni constante, por lo que muchos pacientes no las presentan en el momento del diagnóstico. Presentamos 2 casos de síndrome LEOPARD sin sordera ni estenosis pulmonar en los que la detección de la mutación en el gen PTPN11 permitió confirmar la enfermedad, y señalamos la importancia del seguimiento continuado para la detección precoz de las complicaciones, ya que las mismas pueden aparecer en el transcurso de la enfermedad (AU)


LEOPARD syndrome is an autosomal dominant disease caused by germline mutations in the RAS-MAPK (mitogen-activated protein kinase) pathway. LEOPARD is an acronym for the main manifestations of the syndrome, namely, multiple Lentigines, Electrocardiographic conduction abnormalities, Ocular hypertelorism, Pulmonary stenosis, Abnormalities of genitalia, Retardation of growth, and sensorineural Deafness. None of these characteristic features however, are pathognomonic of LEOPARD syndrome, and since they are highly variable, they are often not present at the time of diagnosis. We describe 2 cases of LEOPARD syndrome without hearing loss or pulmonary stenosis in which diagnosis was confirmed by identification of a mutation in the PTPN11 gene. Regular monitoring is important for the early detection of complications, as these can occur at any time during the course of disease (AU)


Assuntos
Criança , Humanos , Masculino , Síndrome LEOPARD/diagnóstico , Surdez/epidemiologia , Estenose da Valva Pulmonar/epidemiologia , Manchas Café com Leite/epidemiologia , Lentigo/epidemiologia
11.
Int J Dermatol ; 54(7): 778-84, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-25771683

RESUMO

BACKGROUND: Melanoma is considered a heterogeneous tumor with genetic and environmental factors involved in its pathogenesis. The impact of these factors varies depending on age. OBJECTIVE: The aim of this study was to characterize the epidemiological, phenotypic, and histological features of patients with melanoma according to three age groups: ≤40, 41-65, and >65 years. METHODS: A total of 1122 consecutive patients with invasive melanoma definitively treated in our institution since January 2000 were selected from our melanoma database. Epidemiological, phenotypic, and histological data were retrieved and analyzed as a function of age. RESULTS: Female patients predominated in the younger age group. The location of cutaneous malignant melanoma differed with age. In the younger and middle age groups, tumors presented mainly on the trunk, while in the older group they were mainly found on the head/neck. Signs of actinic damage such as actinic keratoses, solar lentigines, or other skin tumors increased with age, while genetic factors such as family history of melanoma or a high number of common melanocytic nevi were more frequent in the younger group. CONCLUSION: Our results suggest that melanoma development in younger patients is the result of genetic factors, particularly related to multiple nevi, whereas in older patients environmental factors such as severe chronic sun exposure play a major role.


Assuntos
Neoplasias de Cabeça e Pescoço/epidemiologia , Melanoma/epidemiologia , Neoplasias Cutâneas/epidemiologia , Adulto , Fatores Etários , Idoso , Feminino , Interação Gene-Ambiente , Neoplasias de Cabeça e Pescoço/patologia , Humanos , Ceratose Actínica/epidemiologia , Lentigo/epidemiologia , Masculino , Melanoma/genética , Melanoma/patologia , Pessoa de Meia-Idade , Fenótipo , Receptor Tipo 1 de Melanocortina/genética , Estudos Retrospectivos , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/patologia , Espanha/epidemiologia , Tronco
12.
Eur J Dermatol ; 23(5): 663-70, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24135214

RESUMO

OBJECTIVES: As outdoor workers, seafarers have high levels of work-related exposure to UV radiation. Considering the various ethnic shipboard crews, this study aimed to assess the prevalence of UV induced skin ageing symptoms among seafarers and their attitude towards sunlight exposure. METHODS: One dermatologist examined 514 seafarers and documented the presence of 11 extrinsic skin ageing symptoms. Based on a questionnaire, the seafarers' attitudes and sun protection were evaluated. RESULTS: On average, 4 extrinsic skin ageing symptoms were found among the seafarers without significant differences between ethnic groups. Teleangiectasis (n = 381), coarse wrinkles (n = 315) and lentigines solares (n = 228) were the most frequently observed extrinsic symptoms. In the multivariate analysis, the parameters current smoking (OR 1.52 (1.01-2.27)), shipboard rank (deck personnel, galley staff vs. engine room personnel; (OR 1.40 (1.01-1.94)), and age (OR 1.07 (1.05-1.10)) were significantly associated with developing skin ageing symptoms. Only half of the seafarers examined were aware of their elevated risk of photodamage due to their high UV exposure at sea. More non-Caucasian than Caucasian seafarers perceived tanned skin as rather positive (78.0% vs. 52.4%; p = 0.002); however, more Caucasian than non-Caucasian seafarers enjoyed intensive sunbathing (17.0% vs. 14.0%). Furthermore, 55.7% of the seafarers (significantly more often Caucasians) used sunscreens during sunlight exposure at sea. CONCLUSIONS: The various ethnic groups examined differed in their attitude and behaviour towards shipboard sun exposure. Education of shipboard crews is required about possible severe health effects due to sun exposure at sea.


Assuntos
Lentigo/epidemiologia , Exposição Ocupacional/efeitos adversos , Navios , Envelhecimento da Pele , Luz Solar/efeitos adversos , Telangiectasia/epidemiologia , Raios Ultravioleta/efeitos adversos , Adulto , Fatores Etários , Idoso , Estudos Transversais , Eritema/epidemiologia , Eritema/etiologia , Comportamentos Relacionados com a Saúde/etnologia , Conhecimentos, Atitudes e Prática em Saúde/etnologia , Humanos , Lentigo/etiologia , Masculino , Pessoa de Meia-Idade , Medicina Naval , Saúde do Trabalhador , Prevalência , Fatores de Risco , Envelhecimento da Pele/etnologia , Fumar , Protetores Solares/uso terapêutico , Telangiectasia/etiologia
13.
J Eur Acad Dermatol Venereol ; 27(3): e345-56, 2013 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22924836

RESUMO

BACKGROUND: To date, few epidemiological data on the relationships between solar lentigines, freckles and behavioural and constitutional risk factors in Caucasian populations exist. OBJECTIVES: To investigate the potential impact of behavioural and phenotypic variables, as well as the MC1R genetic background, on the history of facial freckles and the severity of solar lentigines in Caucasian women. METHODS: The severity of solar lentigines was graded from facial digital images of 523 French middle-aged women by a dermatologist and summarized by a score afterwards. The history of facial freckles was assessed and the sun-exposure behaviour was characterized using a six-category typology. Risk factors including MC1R polymorphism were evaluated using logistic regression models. RESULTS: Two constitutive host factors were found to be independently associated with a history of facial freckles: frequent sunburns and the presence of diminished function variants of the MC1R gene. In addition to age, five factors were independently associated with solar lentigines: constitutive host factors (dark skin colour and tanning capacity), a history of freckles, sun-exposure behaviour and current intake of oral contraceptive or progestogen treatments. CONCLUSION: These results strengthen the hypothesis that solar lentigines are markers of photoaging, whereas freckles are mainly determined by genetic factors. The finding that hormonal treatment is associated with a higher risk for solar lentigines merits further investigations.


Assuntos
Lentigo/epidemiologia , Melanose/epidemiologia , Luz Solar , Adulto , Idoso , Canadá/epidemiologia , Estudos Transversais , Feminino , Humanos , Pessoa de Meia-Idade , Receptor Tipo 1 de Melanocortina/genética , Fatores de Risco
14.
Int J Dermatol ; 50(10): 1286-90, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21950299

RESUMO

BACKGROUND: Basal cell carcinoma (BCC) is the most common cancer to occur in Caucasian populations, and its incidence is increasing. Despite its frequency, there is a paucity of data on risk factors for BCC in some regions. OBJECTIVES: This study investigated the association between pigmentary characteristics, distinctive patterns of solar exposure, habits and lifestyle, and risk for BCC among patients attending a dermatology center in a region in southern Brazil. METHODS: We conducted a hospital-based, case-control study that included 127 case patients with histologically confirmed BCC and 280 cancer-free control subjects with other dermatologic conditions, observed between January 2006 and December 2007. The study was conducted using a questionnaire and physical examination by a dermatologist. Relative risks were estimated using exposure odds ratios generated by cross-tabulation and logistic regression models. RESULTS: Risk for BCC was associated with family history of skin cancer, Fitzpatrick skin type I, and the presence of actinic keratoses, solar lentigines, leukoderma, and elastosis romboidalis nuchae. No effect was found for different patterns of solar exposure, eye, hair or skin color, exposure to non-solar ultraviolet radiation (UVR), or lifestyle-related habits such as sunscreen use and cigarette smoking. CONCLUSIONS: The results of this study suggest that skin type and family history of skin cancer may be important in establishing risk for developing BCC. Additionally, the detection by clinical examination of skin markers related to UVR action is important in establishing which patients are more likely to develop BCC.


Assuntos
Carcinoma Basocelular/epidemiologia , Neoplasias Cutâneas/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Brasil/epidemiologia , Feminino , Humanos , Ceratose Actínica/epidemiologia , Lentigo/epidemiologia , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Pigmentação da Pele , Queimadura Solar/epidemiologia , Luz Solar/efeitos adversos , Inquéritos e Questionários , Raios Ultravioleta/efeitos adversos , Adulto Jovem
15.
Pediatr Dermatol ; 27(5): 453-8, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20561241

RESUMO

Ichthyosis is a heterogeneous cornification disorder. Melanocytic lesions have not been previously described in association with ichthyosis. Their clinical importance lies in the fact that they may simulate melanoma clinically and dermoscopically, as seen in epidermolysis bullosa. The objective of this study was to evaluate the clinical, dermoscopic, and histopathologic features of nevi and lentigines in 16 patients with autosomal recessive congenital ichthyosis-lamellar ichthyosis and nonbullous ichthyosiform congenital erythroderma. Patients underwent general clinical examination dermoscopy. The more suspicious lesions were excised and to histopathologic examination. Most patients (n = 13) reported no personal or familial history of melanoma or atypical nevi. All of the patients had at least five atypical melanocytic lesions. Ten of the 16 patients had at least one atypical nevus or lentigo. This study suggests that increased atypical melanocytic nevi may be a feature of long-standing congenital ichthyoses. Whether this finding is disease-related or a coincidental observation is difficult to ascertain. As an unequivocal discrimination from malignant melanoma in vivo is not always possible, regular clinical follow-up of patients with ichthyosis and increased or unusual nevi is recommended.


Assuntos
Ictiose/epidemiologia , Ictiose/patologia , Nevo Pigmentado/epidemiologia , Nevo Pigmentado/patologia , Adolescente , Adulto , Biópsia , Brasil/epidemiologia , Criança , Feminino , Humanos , Ictiose/genética , Incidência , Lentigo/epidemiologia , Lentigo/patologia , Masculino , Adulto Jovem
16.
Dermatol Online J ; 16(1): 1, 2010 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-20137743

RESUMO

The term "melanocytic nevus" comprises a group of clinically and pathologically distinct subtypes. In this prospective clinical study we evaluated the frequency, localization, and age and gender distribution of flat nevi (FN), Miescher nevi (MN), and Unna nevi (UN) in a caucasian population. Nevi were counted in 400 patients, of which 47 had a history of melanoma. Additionally, the patients answered to a detailed UV questionnaire. Flat nevi represented the most common type of melanocytic nevi, with a peak in the 3rd decade of life. They were mostly found on the extremities and on the trunk. Miescher nevi were most common in the 6th decade and were predominantly found in the head and neck region. Unna nevi showed a maximum in the 8th decade and they were mainly situated on the trunk. The counts of all three nevus subtypes were elevated in the melanoma group. Our results confirm that FN, MN, and UN represent melanocytic nevi with distinctive morphological and clinical characteristics. The role of sunlight seems to be more prominent in the pathogenesis of FN. The precise description of FN, MN, and UN may serve as a base for a pathogenetic distinction of subtypes of melanocytic nevi in the future.


Assuntos
Nevo Pigmentado/classificação , Neoplasias Cutâneas/classificação , Adolescente , Adulto , Idade de Início , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Neoplasias Faciais/epidemiologia , Feminino , Humanos , Ceratose Seborreica/epidemiologia , Lentigo/epidemiologia , Masculino , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/epidemiologia , Neoplasias Primárias Múltiplas/patologia , Nevo Pigmentado/epidemiologia , Nevo Pigmentado/patologia , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/patologia , Luz Solar/efeitos adversos , Adulto Jovem
17.
J Cosmet Dermatol ; 7(3): 164-8, 2008 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-18789050

RESUMO

BACKGROUND: Pigmentary disorders are commonly seen in dermatology practice and can have a negative psychosocial impact on patients. OBJECTIVE: This study aims to examine the prevalence of pigmentary disorders and their level of psychological and physical impact on patients. METHODS: A prospective cohort study involved a sample of 140 patients undergoing skin exams at a private dermatology practice in North Carolina. Patient demographics and pigmentary diagnoses were obtained, and participants were asked to fill out a skin discoloration impact evaluation questionnaire. Descriptive and frequency analyses were performed. RESULTS: Around 80% of the participants were diagnosed with one or more pigmentary disorders. About 47.3% of patients admitted of feeling self-conscious about their skin to some degree, 21.8% felt others focused on their skin, 32.7% felt unattractive because of their skin, 32.7% put effort into hiding pigment changes, and 23.6% felt their skin affected their activities. A limitation was the lack of diversity in the population studied (gender and skin type). CONCLUSIONS: Pigmentary disorders such as melasma, vitiligo, and lentigo pose significant negative impact on a person's health-related quality of life. Hence, there is a need for effective treatments of pigmentary disorders based on their prevalence and effect on quality of life. Healthcare providers should consider the impact of pigmentary disorders on health-related quality of life and educate patients on possible treatments.


Assuntos
Transtornos da Pigmentação/epidemiologia , Transtornos da Pigmentação/psicologia , Estudos de Coortes , Feminino , Humanos , Hiperpigmentação/epidemiologia , Hiperpigmentação/psicologia , Lentigo/epidemiologia , Lentigo/psicologia , Masculino , Melanose/epidemiologia , Melanose/psicologia , North Carolina/epidemiologia , Prevalência , Estudos Prospectivos , Qualidade de Vida , Amostragem , Perfil de Impacto da Doença , Inquéritos e Questionários , Vitiligo/epidemiologia , Vitiligo/psicologia
18.
Dermatology ; 217(1): 38-44, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18367839

RESUMO

BACKGROUND: Marathon runners seem to have an increased melanoma risk. OBJECTIVE: To identify potential melanoma markers. METHODS: 150 marathon runners volunteered to take part in the skin cancer screening campaign. After the runners completed a questionnaire about melanoma risk factors, types of sportswear and training programs, they received a total skin examination. The number of lentigines and nevi on the left shoulder and the left buttock were counted in each participant using templates in standardized positions. The potential association of training sportswear and training parameters with the number of lentigines and nevi on the left shoulder was evaluated. RESULTS: The mean number of lentigines on the left shoulder was 19.6 +/- 18.2 (SD), whereas no lentigines were found on the left buttock (p = 0.000). The number of nevi also differed significantly between the 2 localizations with higher numbers on the left shoulder (p = 0.000). While lifetime sunburn history and type of sportswear correlated with the number of lentigines, training parameters had an impact on the number of nevi. Independent of their mean weekly running time, runners with higher heart rates while training, higher training velocities and higher physical strain indexes showed more nevi on the shoulder than the other runners (p = 0.029, 0.046, 0.038, respectively). CONCLUSION: Sun exposure and high physical strain lead to an increase in melanoma markers such as lentigines and nevi in marathon runners.


Assuntos
Lentigo/epidemiologia , Melanoma/epidemiologia , Nevo/epidemiologia , Corrida/fisiologia , Neoplasias Cutâneas/epidemiologia , Luz Solar/efeitos adversos , Adulto , Idoso , Análise de Variância , Vestuário , Feminino , Frequência Cardíaca , Humanos , Lentigo/diagnóstico , Lentigo/etiologia , Masculino , Melanoma/etiologia , Pessoa de Meia-Idade , Nevo/diagnóstico , Nevo/etiologia , Estudos Prospectivos , Fatores de Risco , Ombro/patologia , Pele/patologia , Neoplasias Cutâneas/etiologia , Pigmentação da Pele , Estatísticas não Paramétricas , Queimadura Solar/epidemiologia , Inquéritos e Questionários
19.
Dermatology ; 216(4): 330-6, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18230982

RESUMO

BACKGROUND: Multiple solar lentigines of the upper back and shoulders (MSLBS) have recently been demonstrated as being associated with intense sunburns in the past. OBJECTIVE: To determine the prevalence of MSLBS among patients with cutaneous melanoma. METHODS: Thisprevalence study was conducted prospectively from October 2003 to November 2004 in a single department of dermatology (Reims University Hospital, north of France). One hundred and twenty-five adult patients, followed up for a cutaneous melanoma, were included, and the prevalence of MSLBS was determined, with comparison of clinical characteristics of patients with and without these lesions. RESULTS: The prevalence of MSLBS among patients with cutaneous melanoma was 37.6%. MSLBS were significantly and independently associated with cutaneous melanoma of the back in multivariate analysis (adjusted odds ratio, OR = 4.3, 95% confidence interval, CI = 1.5-12.3) and with recalled episodes of severe sunburn before the age of 28 (OR = 3.4, 95% CI = 1.3-9.4). CONCLUSION: Large irregularly shaped brown macules of the upper back and shoulders or MSLBS are frequent among adult patients with cutaneous melanoma. They are associated with melanoma located on the upper back. This topographical association further illustrates the relation between past intense sunburns and cutaneous melanoma. MSLBS should be evaluated as an easily recognizable clinical marker of the risk of cutaneous melanoma.


Assuntos
Lentigo/epidemiologia , Neoplasias Cutâneas/epidemiologia , Queimadura Solar/complicações , Raios Ultravioleta/efeitos adversos , Idoso , Dorso , Feminino , Humanos , Lentigo/etiologia , Masculino , Melanoma/epidemiologia , Melanoma/etiologia , Pessoa de Meia-Idade , Razão de Chances , Prevalência , Estudos Prospectivos , Fatores de Risco , Neoplasias Cutâneas/etiologia , Pigmentação da Pele , Queimadura Solar/epidemiologia
20.
Int J Dermatol ; 45(4): 397-401, 2006 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-16650166

RESUMO

BACKGROUND: For Greece, no data regarding the incidence of cutaneous melanoma (CM) have been reported. In this report, we present epidemiologic data for CM on Crete, an island in southern Greece, during the years 1999-2002. We attempt a comparison with corresponding data reported for the Italian population. METHODS: One hundred and two CM patients of Cretan origin with primary CM first diagnosed between the years 1999-2002 were interviewed and underwent complete skin examination by the same two experienced dermatologists. Crude and/or age-standardized incidence rates were calculated for Crete as a whole, as well as for each one of the four prefectures of the island. RESULTS: The age-standardized incidence rate according to the Greek population was 4.6 per 100,000 person-years for men and 4.7 per 100,000 person-years for women. The crude incidence rates did not differ significantly between the four prefectures. Significant differences between Cretan and Italian CM patients were found in terms of gender, age at diagnosis, anatomic site and histogenetic type of CM, hair color, skin reaction to sun exposure, history of sunburn before the age of 15 years, presence of solar lentigines, and total common nevus count. CONCLUSIONS: The incidence of CM on Crete is higher than that estimated for the whole of Greece and comparable with the incidence reported for other southern European countries.


Assuntos
Melanoma/epidemiologia , Neoplasias Cutâneas/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Grécia/epidemiologia , Cor de Cabelo , Humanos , Incidência , Lactente , Recém-Nascido , Itália/epidemiologia , Lentigo/epidemiologia , Masculino , Pessoa de Meia-Idade , Nevo Pigmentado/epidemiologia , Distribuição por Sexo , Fatores Sexuais , Queimadura Solar/complicações , Queimadura Solar/epidemiologia
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