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1.
PLoS One ; 14(12): e0225682, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31810078

RESUMO

Oral leukoplakia (OL) is a potentially malignant oral disorder. The Gold Standard treatment is to remove surgically the OL. Despite optimal surgery, the recurrence rates are estimated to be 30%. The reason for this is unknown. The aim of this study was to investigate the clinical factors that correlate with recurrence after surgical removal of OL. In a prospective study data were collected from 226 patients with OL. Forty-six patients were excluded due to incomplete records or concomitant presence of other oral mucosal diseases. Overall, 180 patients proceeded to analysis (94 women and 86 men; mean age, 62 years; age range, 28-92 years). Clinical data, such as gender, diagnosis (homogeneous/non-homogeneous leukoplakia), location, size, tobacco and alcohol use, verified histopathological diagnosis, and clinical photograph, were obtained. In patients who were eligible for surgery, the OL was surgically removed with a margin. To establish recurrence, a healthy mucosa between the surgery and recurrence had to be confirmed in the records or clinical photographs. Statistical analysis was performed with the level of significance set at P<0.05. Of the 180 patients diagnosed with OL, 57% (N = 103) underwent surgical removal in toto. Recurrence was observed in 43 OL. The cumulative incidence of recurrence of OL was 45% after 4 years and 49% after 5 years. Fifty-six percent (N = 23) of the non-homogeneous type recurred. Among snuff-users 73% (N = 8) cases of OL recurred. A non-homogeneous type of OL and the use of snuff were significantly associated with recurrence after surgical excision (P = 0.021 and P = 0.003, respectively). Recurrence was also significantly associated with cancer transformation (P<0.001). No significant differences were found between recurrence and any of the following: dysplasia, site of lesion, size, multiple vs. solitary OL, gender, age, use of alcohol or smoking. In conclusion, clinical factors that predict recurrence of OL are non-homogeneous type and use of snuff.


Assuntos
Transformação Celular Neoplásica/patologia , Leucoplasia Oral/cirurgia , Mucosa Bucal/patologia , Recidiva Local de Neoplasia/epidemiologia , Procedimentos Cirúrgicos Bucais , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Incidência , Leucoplasia Oral/epidemiologia , Leucoplasia Oral/etiologia , Leucoplasia Oral/patologia , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/etiologia , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/prevenção & controle , Estudos Prospectivos , Fatores de Risco , Tabaco sem Fumaça/efeitos adversos , Resultado do Tratamento , Adulto Jovem
2.
Oral Dis ; 25(7): 1707-1714, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31295753

RESUMO

OBJECTIVES: To identify molecular characteristics of keratosis of unknown significance and to nominate pathways of molecular progression to oral cancer. Our work could provide a rationale for monitoring and treating these lesions definitively. METHODS: Patients with oral leukoplakia were eligible for our prospective observational study. We correlated alterations in cancer-associated genes with clinical and histopathologic variables (keratosis of unknown significance vs. moderate-to-severe dysplasia) and compared these alterations to a previously molecularly characterized oral cancer population. RESULTS: Of 20 enrolled patients, 13 (65%) had evidence of keratosis of unknown significance, while seven (35%) had dysplasia. Nine patients (45%) developed oral cancer (4/13 with keratosis of unknown significance, 5/7 with dysplasia). At a median follow-up of 67 (range 22-144) months, median overall survival was significantly shorter for patients with dysplasia (hazard ratio 0.11, p = .02). KMT2C and TP53 alterations were most frequent (75% and 35%, respectively). There were molecular similarities between keratosis of unknown significance and dysplasia patients, with no significant differences in mutational frequency among genes with ≥15% rate of alteration. CONCLUSIONS: Among patients with leukoplakia, both patients with keratosis of unknown significance and patients with dysplasia developed oral cancer. Molecular alterations between these two groups were similar at this sample size.


Assuntos
Ceratose/epidemiologia , Leucoplasia Oral/etiologia , Neoplasias Bucais/genética , Lesões Pré-Cancerosas/epidemiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Genômica , Humanos , Ceratose/patologia , Leucoplasia Oral/epidemiologia , Leucoplasia Oral/genética , Leucoplasia Oral/patologia , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/epidemiologia , Lesões Pré-Cancerosas/patologia , Estudos Prospectivos
3.
J Cancer Res Ther ; 15(3): 620-624, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31169230

RESUMO

Background and Objectives: Quid-chewing habit is a common and old tradition in India. It causes various potentially malignant disorders. Therefore, a study was undertaken to analyze the association of various quid-chewing habit patterns and different oromucosal lesions. Materials and Methods: A cross-sectional study was conducted on 150 cases, where all the individuals selected were having quid-chewing habit and oromucosal lesions. Detailed habit history was taken through preformed questionnaire, clinical examination was done, and the lesion was subjected to incisional biopsy and confirmed histopathologically. Results: The male to female ratio of various quid-chewing habit and oromucosal lesions was 9:1. The middle aged were more commonly involved. Of the various types of quids chewed, a combination of processed betel and processed tobacco which is commercially available was used by majority of the individuals. Oral submucous fibrosis (OSMF) was seen in majority of the cases. Interpretation and Conclusion: The present study confirms the association between betel, tobacco, and various lesions such as OSMF, leukoplakia, chewer's mucosa, lichenoid reaction, and chemical burn. It also confirms the strong association of betel to OSMF and tobacco to leukoplakia.


Assuntos
Doenças da Boca/epidemiologia , Doenças da Boca/etiologia , Mucosa Bucal/patologia , Tabaco sem Fumaça/efeitos adversos , Adolescente , Adulto , Criança , Estudos Transversais , Feminino , Hábitos , Humanos , Índia/epidemiologia , Leucoplasia Oral/epidemiologia , Leucoplasia Oral/etiologia , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/epidemiologia , Neoplasias Bucais/etiologia , Fibrose Oral Submucosa/epidemiologia , Fibrose Oral Submucosa/etiologia , Prevalência , Vigilância em Saúde Pública , Adulto Jovem
4.
Indian J Cancer ; 56(1): 15-18, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30950437

RESUMO

OBJECTIVES: This study was conducted to determine the number and types of oromucosal lesions (OMLs) in relation to tobacco habits in patients who attended the outpatient department. METHODOLOGY: A total of 1730 patients visiting the Department of Oral Medicine and Radiology were interviewed and screened for tobacco habits (smoking and smokeless). Clinical oral examination was conducted with diagnostic instruments using the Color Atlas of Common Oral Diseases as a guide for diagnosis. When clinical features were not diagnostic, a biopsy was done. RESULTS: Of the 1730 outpatients, 975 (56.3% ) individuals used tobacco in one or other forms and 687 (70.4%) of these had OMLs. CONCLUSION: The results of this study provide important information on the prevalence of OMLs in patients seeking dental care. This provides baseline data for future studies on the prevalence of oral lesions in the general population.


Assuntos
Leucoplasia Oral/epidemiologia , Mucosa Bucal/patologia , Neoplasias Bucais/epidemiologia , Tabaco/efeitos adversos , Adolescente , Adulto , Fatores Etários , Feminino , Seguimentos , Humanos , Índia/epidemiologia , Leucoplasia Oral/etiologia , Leucoplasia Oral/patologia , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/etiologia , Neoplasias Bucais/patologia , Prevalência , Prognóstico , Fatores Sexuais , Adulto Jovem
5.
PLoS One ; 14(1): e0210901, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30657779

RESUMO

A number of genetic variants were suggested to be associated with oral malignancy, few variants can be replicated. The aim of this study was to identify significant variants that enhanced personal risk prediction for oral malignancy. A total of 360 patients diagnosed with oral squamous cell carcinoma, 486 controls and 17 newly diagnosed patients with OPMD including leukoplakia or oral submucous fibrosis were recruited. Fifteen tagSNPs which were derived from somatic mutations were genotyped and examined in associations with the occurrence of oral malignancy. Environmental variables along with the SNPs data were used to developed risk predictive models for oral malignancy occurrence. The stepwise model analysis was conducted to fit the best model in an economically efficient way. Two tagSNPs, rs28647489 in FAT1 gene and rs550675 in COL9A1 gene, were significantly associated with the risk of oral malignancy. The sensitivity and specificity were 85.7% and 85.5%, respectively (area under the receiver operating characteristic curve (AUC) was 0.91) for predicting oral squamous cell carcinoma occurrence with the combined genetic variants, betel-quid, alcohol and age. The AUC for OPMD was only 0.69. The predictive probability of squamous cell carcinoma occurrence for genetic risk score without substance use increased from 10% up to 43%; with substance use increased from 73% up to 92%. Genetic variants with or without substance use may enhance risk prediction for oral malignancy occurrence in male population. The prediction model may be useful as a clinical index for oral malignancy occurrence and its risk assessments.


Assuntos
Caderinas/genética , Carcinoma de Células Escamosas/etiologia , Carcinoma de Células Escamosas/genética , Colágeno Tipo IX/genética , Neoplasias Bucais/etiologia , Neoplasias Bucais/genética , Adulto , Idoso , Consumo de Bebidas Alcoólicas/efeitos adversos , Areca/efeitos adversos , Estudos de Casos e Controles , Feminino , Interação Gene-Ambiente , Humanos , Leucoplasia Oral/etiologia , Leucoplasia Oral/genética , Masculino , Pessoa de Meia-Idade , Fibrose Oral Submucosa/etiologia , Fibrose Oral Submucosa/genética , Polimorfismo de Nucleotídeo Único , Fatores de Risco , Fumar/efeitos adversos
6.
Oral Oncol ; 87: 58-63, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30527244

RESUMO

OBJECTIVES: To elucidate the risk of malignant transformation to invasive oral cancer by subtypes of oral potentially malignant disorders (OPMD) and to examine the independent effects of risk factors, particularly alcohol drinking, by subtype based on a nationwide oral cancer screening program targeting at general population with habits of smoking and/or betel quids chewing. MATERIALS AND METHODS: The total of 8501 subjects diagnosed as different subtypes of OPMDs from the Taiwanese screening program between 2004 and 2009 were followed up over time to ascertain the occurrence of invasive oral cancer. The hazard ratios of malignant transformation were estimated by using Cox proportional hazards regression model. RESULTS: The overall malignant rate (per 1000 person-years) to oral cancer was 8.4 (407 incident cases with an average of 5.7 years of follow-up). The highest rate was noted in exophytic verrucous hyperplasia (33), followed by erythroplakia (11.8), erythroleukoplakia (10.7), oral submucous fibrosis (OSF) (8.6), and leukoplakia (5.4). After adjusting for confounders, exophytic verrucous hyperplasia still had a 5.69 (4.47-7.24) times risk compared with leukoplakia. The corresponding figures for erythroplakia, erythroleukoplakia, and OSF were 2.25 (1.31-3.89), 2.00 (1.13-3.53), and 1.63 (1.29-2.06), respectively. Alcohol drinking elevated the overall risk of malignant transformation by 23% (1-52% and also triggered a higher risk in OSF (aHR = 1.62 (1.06-2.47)). The higher risk attributed to betel quids chewing was noted for exophytic verrucous hyperplasia (aHR = 4.23 (1.55-11.55)). CONCLUSIONS: The risk of malignant transformation to oral cancer varied with the subtypes of OPMD and was elevated in OSF and verrucous hyperplasia attributed to alcohol drinking and betel quids, respectively.


Assuntos
Transformação Celular Neoplásica/patologia , Detecção Precoce de Câncer/estatística & dados numéricos , Leucoplasia Oral/patologia , Neoplasias Bucais/epidemiologia , Lesões Pré-Cancerosas/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Consumo de Bebidas Alcoólicas/efeitos adversos , Consumo de Bebidas Alcoólicas/epidemiologia , Areca/efeitos adversos , Feminino , Seguimentos , Humanos , Hiperplasia/epidemiologia , Hiperplasia/etiologia , Hiperplasia/patologia , Incidência , Leucoplasia Oral/epidemiologia , Leucoplasia Oral/etiologia , Masculino , Pessoa de Meia-Idade , Mucosa Bucal/patologia , Neoplasias Bucais/diagnóstico , Neoplasias Bucais/patologia , Lesões Pré-Cancerosas/epidemiologia , Lesões Pré-Cancerosas/etiologia , Estudos Prospectivos , Fatores de Risco , Taiwan/epidemiologia , Adulto Jovem
7.
J Pak Med Assoc ; 68(3): 437-443, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29540881

RESUMO

Numerous substances may have an adverse influence on the oral region by virtue of their potentially harmful effects. Dental practitioners are often the first to see these effects in the head and neck region. Knowledge of the damaging consequences of agents such as alcohol, tobacco, areca nut, medications, alcohol-containing mouthwashes, dental devices and materials can assist the practitioners in clinical decision-making and accurate diagnosis of associated lesions. More importantly, timely diagnosis and prompt reporting of such harmful effects improve the quality of care. Such knowledge may also help in patient's education for the avoidance of associated adverse effects (AEs). Consequently, a thorough acquaintance of AEs will consolidate the distinct role of medical and oral health practitioners in safeguarding the patients' oral and systemic well-being. This article was planned to review the harmful consequences of specific substances on the oral health. Traditionally, the emphasis of review articles has been on reviewing the harmful effects of a single entity on oral health. This review is unique in the sense that it comprehensively and collectively focussed on the harmful effects on the oral health of addictive and illicit substances (alcohol, betel nut), medications, alcohol-containing mouthwashes, medications and dental materials.


Assuntos
Consumo de Bebidas Alcoólicas/efeitos adversos , Areca/efeitos adversos , Materiais Dentários/efeitos adversos , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/etiologia , Doenças da Boca/etiologia , Antissépticos Bucais/efeitos adversos , Uso de Tabaco/efeitos adversos , Candidíase Bucal/etiologia , Fibrose/etiologia , Crescimento Excessivo da Gengiva/etiologia , Humanos , Ceratose/etiologia , Leucoplasia Oral/etiologia , Mucosa Bucal , Úlceras Orais/etiologia , Distúrbios do Paladar/etiologia
8.
Acta Odontol Scand ; 76(3): 226-228, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29161938

RESUMO

OBJECTIVES: Electronic cigarettes (ECs) have become very popular in recent years. However, many uncertainties remain about their side effects. This study aims to evaluate the prevalence and characteristics of oral mucosal lesions (OMLs) in former smokers compared to ECs consumers. METHODS: A prospective case-control study was carried out. Outpatients for dental consultation were consecutively enrolled into two groups based on their habits, i.e. former smokers and ECs consumers. Each patient was examined to detect possible oral lesions and, if needed, a swab or biopsy of the lesion was taken for diagnosis. Data was entered into a spreadsheet and analyzed. RESULTS: A total of 90 patients were examined, 45 were former smokers (group A) and 45 were ECs consumers (group B). OMLs were detected in 55 cases, of which 19/55 (34.6%) belonged to group A and 36/55 (65.4%) to group B. Nicotine stomatitis, a hairy tongue and angular cheilitis resulted to be significantly more common among EC consumers. CONCLUSIONS: We found no statistically significant differences in terms of total prevalence of OMLs between former smokers and ECs consumers. An increased prevalence of three specific types of OMLs was detected among ECs consumers.


Assuntos
Sistemas Eletrônicos de Liberação de Nicotina , Leucoplasia Oral/diagnóstico , Fumar/efeitos adversos , Estomatite Aftosa/diagnóstico , Língua Fissurada/diagnóstico , Adulto , Feminino , Humanos , Leucoplasia Oral/etiologia , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Fumantes , Estomatite Aftosa/etiologia , Produtos do Tabaco/efeitos adversos , Língua Fissurada/etiologia
9.
Cancer Epidemiol ; 47: 118-124, 2017 04.
Artigo em Inglês | MEDLINE | ID: mdl-28259083

RESUMO

OBJECTIVE: Oral cancer (OC) is a leading cause of death from cancer in men between the ages of 25 and 44 years in Taiwan. The overall 5-year survival rates for the four OC stages (I-IV) in Taiwan are approximately 70%, 30%, 20%, and 10%, respectively, indicating the importance of the early diagnosis of oral potentially malignant disorders (OPMDs). Previous studies indicated an association between the OC incidence and certain environmental heavy metal concentrations. If these associations do exist for OC, they may also be observed for OPMD. The purpose of this study is to explore the association between the development of OPMD to OC and environmental heavy metals. Oral submucous fibrosis (OSF) and oral leukoplakia (OL) are two major types of OPMD in Taiwan. MATERIALS AND METHODS: A retrospective cohort study was conducted by Changhua Christian Hospital, the sole medical center in Changhua County, where 2725 male adult patients diagnosed with either OSF or OL between 2000 and 2014 were recruited. Data were analyzed by Cox regression and adjusted for smoking and betel-quid chewing. RESULTS AND DISCUSSION: OPMD patients who resided in areas with high nickel concentrations (polluted levels) exhibited hazard ratios of 1.8-2 for OC relative to those who lived in areas with low nickel levels (P<0.01). Meanwhile, smokers with OPMDs had a hazard ratio of 2.8-2.9 relative to non-smokers. Betel-quid chewers had a 2.2-2.3 hazard ratio relative to non-chewers. Smoking, betel-quid chewing, and environmental nickel exposure are associated with an increased risk of OC development in OPMD patients. This study provides valuable findings on the environmental effects of heavy metals on human health. Enhanced surveillance of the condition of OPMD patients who have been exposed to high nickel concentrations may be crucial for OC prevention.


Assuntos
Exposição Ambiental/efeitos adversos , Poluição Ambiental/efeitos adversos , Leucoplasia Oral/etiologia , Metais Pesados/efeitos adversos , Neoplasias Bucais/etiologia , Fibrose Oral Submucosa/etiologia , Lesões Pré-Cancerosas/etiologia , Adulto , Progressão da Doença , Feminino , Humanos , Leucoplasia Oral/patologia , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/patologia , Fibrose Oral Submucosa/patologia , Lesões Pré-Cancerosas/patologia , Estudos Retrospectivos , Fatores de Risco , Taiwan
10.
Braz J Otorhinolaryngol ; 83(5): 585-593, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28209441

RESUMO

INTRODUCTION: Proliferative verrucous leukoplakia is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations. OBJECTIVE: To analyze the studies about Proliferative verrucous leukoplakia and develop a concise update. METHODS: A Pubmed search identifying studies (laboratory research, case series and reviews of literature) that examined patients with Proliferative verrucous leukoplakia was realized. RESULTS: There are not enough studies about Proliferative verrucous leukoplakia in the literature. The few found studies not present a consensus about its etiology and diagnosis criteria. Although several treatment strategies have been proposed, most of them still show a high recurrence rate. CONCLUSION: More research about Proliferative verrucous leukoplakia is necessary to understand and treat this disease.


Assuntos
Leucoplasia Oral , Feminino , Humanos , Leucoplasia Oral/diagnóstico , Leucoplasia Oral/etiologia , Leucoplasia Oral/patologia , Leucoplasia Oral/terapia , Masculino
11.
Aust Dent J ; 62(1): 47-51, 2017 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-27219072

RESUMO

BACKGROUND: Among potentially malignant disorders, oral leukoplakia is the most common in clinical practice. The aim of this study was to assess risk factors associated with oral leukoplakia. METHODS: This retrospective study included 142 patients diagnosed with oral leukoplakia according to World Health Organization clinical and histopathological criteria and a control group of healthy subjects matched for age and gender. Sociodemographic data were registered for each patient: age, gender, smoking and alcohol consumption. Leukoplakia characteristics were also registered: size, position, clinical form, and presence or absence of dysplasia; all cases of leukoplakia were classified systematically according to clinicopathological stage. Blood lipid component levels of total cholesterol, high-density lipoproteins, low-density lipoproteins and triglycerides were compared between groups. RESULTS: Smoking had a significant effect on the risk of leukoplakia (P = 0.01, odds ratio (OR) = 8.33). High glucose levels also increased the probability of leukoplakia (P = 0.03, OR = 6.35), as did low-density lipoproteins (P = 0.049, OR = 5.65). The risk of dysplasia increased among patients presenting the non-homogeneous form of leukoplakia (P = 0.039, OR = 9.06) and among smokers (P = 0.044, OR = 28.33). CONCLUSIONS: Smoking, increased glucose and low-density lipoproteins in the blood are associated with a risk of oral leukoplakia.


Assuntos
Leucoplasia Oral/epidemiologia , Neoplasias Bucais/epidemiologia , Fatores Etários , Glicemia , Estudos de Casos e Controles , Feminino , Humanos , Leucoplasia Oral/etiologia , Leucoplasia Oral/patologia , Lipídeos/sangue , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/etiologia , Neoplasias Bucais/patologia , Estudos Retrospectivos , Fatores de Risco , Fumar/efeitos adversos , Fatores Socioeconômicos , Espanha/epidemiologia
12.
J Cancer Res Ther ; 12(2): 469-73, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27461595

RESUMO

Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behavior due to its high probability of recurrence and a high rate of malignant transformation, usually higher than 70%. PVL is a long-term progressive condition, which is observed more frequently in elderly women, over 60 years at the time of diagnosis. The buccal mucosa and tongue are the most frequently involved sites. It develops initially as a white plaque of hyperkeratosis that eventually becomes a multifocal disease with confluent, exophytic and proliferative features with a progressive deterioration of the lesions, making it more and more difficult to control. Tobacco use does not seem to have a significant influence on the appearance or progression of PVL and may occur both in smokers and nonsmokers. Prognosis is poor for this seemingly harmless-appearing white lesion of the oral mucosa. At present, the etiology of PVL remains unclear as well as its management and diagnosis, which is still retrospective, late and poorly defined, lacking consensus criteria. This short review discusses the clinical and histopathological features, diagnosis, traditional treatment and the current management of the disease.


Assuntos
Leucoplasia Oral/diagnóstico , Leucoplasia Oral/terapia , Transformação Celular Neoplásica , Diagnóstico Diferencial , Gerenciamento Clínico , Humanos , Leucoplasia Oral/epidemiologia , Leucoplasia Oral/etiologia , Recidiva
13.
J Investig Clin Dent ; 7(4): 417-423, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26075572

RESUMO

OBJECTIVE: Exophytic oral verrucous hyperplasia (OVH) is a new entity described by an expert working group from South Asia. First reported in Taiwan, there are no reports so far from an Indian population. The aim was to use the microscopic features described by the expert group to differentiate OVH from other oral verruco-papillary lesions in an Indian archive. MATERIALS AND METHODS: In a retrospective multicentre study, using pathology archives, 188 verruco-papillary lesions were retrieved from pathology archives. A proforma listing histopathological criteria for OVH based on published guidelines (Annals of Dentistry, University of Malaya, 2013) was used. Patients' demographic and clinical data were transcribed from patient charts. The Pearson chi-square test was used to determine associations between clinical and histopathological features. RESULTS: Of 188 oral verruco-papillary lesions that were evaluated, based on microscopic features the cases were reclassified as OVH (57), verrucous carcinoma (VC) (84), oral squamous cell carcinoma (16), and other verruco-papillary lesions (31). Both OVH (70%) and VC (60%) showed male predominance and commonly affected buccal mucosa (OVH 74% and VC 57%). Absence of downward growth of the hyperplastic epithelium into lamina propria when compared with the level of the basement membrane of the adjacent normal epithelium was a distinct feature in OVH. Keratin plugging, epithelial dysplasia and subepithelial lymphocytic infiltration were found to be significantly different (P < 0.05) in OVH versus VC. The sample size of other verruco-papillary lesions was insufficient for statistical comparison. CONCLUSION: Apart from the absence of an endophytic growth pattern in OVH, we noted the presence of dysplasia in OVH. This significant observation does institute a debate as to whether this enigmatic lesion could possibly be a precedent of oral squamous or verrucous carcinoma. We propose OVH is a distinct entity in our Indian population and should be considered in the classification of oral potentially malignant disorders.


Assuntos
Hiperplasia/etiologia , Hiperplasia/patologia , Doenças da Boca/complicações , Doenças da Boca/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma de Células Escamosas/etiologia , Carcinoma de Células Escamosas/patologia , Carcinoma Verrucoso/etiologia , Carcinoma Verrucoso/patologia , Transformação Celular Neoplásica/patologia , Distribuição de Qui-Quadrado , Epitélio/patologia , Feminino , Humanos , Hiperplasia/diagnóstico , Hiperplasia/diagnóstico por imagem , Índia , Leucoplasia Oral/diagnóstico , Leucoplasia Oral/diagnóstico por imagem , Leucoplasia Oral/etiologia , Leucoplasia Oral/patologia , Masculino , Pessoa de Meia-Idade , Doenças da Boca/diagnóstico , Mucosa Bucal/patologia , Neoplasias Bucais/etiologia , Neoplasias Bucais/patologia , Estudos Retrospectivos , Fumar/efeitos adversos , Uso de Tabaco , Adulto Jovem
15.
Intern Med ; 54(22): 2867-72, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26568000

RESUMO

Nail dystrophy, oral leukoplakia and abnormal skin pigmentation are the defining features of dyskeratosis congenita. Dyskeratosis congenita is a disorder of poor telomere maintenance and is known to increase the risk of developing multiple types of malignancy. However, there are few reports of liver tumors arising in dyskeratosis congenita patients. We herein report the second case of hepatic angiosarcoma arising from dyskeratosis congenita: a 23-year-old man was introduced to our hospital due to the detection of multiple tumors in the liver. A histological analysis showed angiosarcoma that stained positive for antibodies to both CD31 and blood coagulation factor VIII.


Assuntos
Disceratose Congênita/complicações , Hemangiossarcoma/etiologia , Leucoplasia Oral/etiologia , Neoplasias Hepáticas/etiologia , Adulto , Disceratose Congênita/patologia , Fator VIII/metabolismo , Evolução Fatal , Hemangiossarcoma/patologia , Humanos , Leucoplasia Oral/patologia , Neoplasias Hepáticas/patologia , Masculino , Molécula-1 de Adesão Celular Endotelial a Plaquetas/sangue
16.
Aust Dent J ; 60(3): 404-7, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-26211810

RESUMO

Oral squamous cell carcinoma (OSCC) is one of the most common solid tumours occurring after haematopoietic stem cell transplantation (HSCT), especially in patients with chronic graft-versus-host-disease (cGVHD). We describe a case of OSCC that developed in a 51-year-old male 22 years after he had received allogeneic HSCT from his human leukocyte antigen-identical sister as a treatment for acute myelocytic leukaemia. The patient had presented with multiple white patchy lesions on the palatal gingiva and mucosa 16 years after HSCT; these lesions were consistent with the clinical features of cGVHD. Six years later, oral examination and biopsy revealed upper gingival squamous cell carcinoma (SCC) in areas of cGVHD, and he underwent tumour excision. Follow-up examination at 2 years and 4 months after the operation revealed no evidence of recurrence of local SCC or metastasis of the cervical lymph node. The current case highlights the susceptibility of patients with cGVHD to the development of OSCC even two decades after HSCT. Therefore, we recommend careful long-term follow-up of the oral cavity for patients with cGVHD.


Assuntos
Carcinoma de Células Escamosas/etiologia , Neoplasias Gengivais/etiologia , Doença Enxerto-Hospedeiro/etiologia , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Aloenxertos/transplante , Transformação Celular Neoplásica/patologia , Suscetibilidade a Doenças , Seguimentos , Humanos , Leucemia Mieloide/terapia , Leucoplasia Oral/etiologia , Masculino , Pessoa de Meia-Idade , Indução de Remissão
17.
J Cancer Res Ther ; 11(1): 146-9, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25879353

RESUMO

BACKGROUND: Several studies in recent years have linked association between micronutrient levels and various forms of cancer. Copper and zinc have been the most researched micronutrients. AIM: The aim of the study was to evaluate the levels of copper, zinc and iron in saliva of patients with oral leukoplakia, oral submucous fibrosis and oral squamous cell carcinoma. RESULTS: There was a highly significant increase in the level of salivary copper in oral submucous fibrosis patients when compared to controls (P = 0.001). Salivary copper levels were also elevated in oral leukoplakia and oral cancer patients (P = 0.01). There was a significant decrease in the salivary zinc levels in all three study groups when compared to controls (P = 0.001). A highly significant reduction in salivary iron levels was noticed oral submucous fibrosis group. The copper to zinc ratio significantly increased in all the study groups when compared to controls. CONCLUSION: Results suggest that salivary copper zinc and iron could be used as biomarkers for oral precancer and cancer.


Assuntos
Neoplasias Bucais/etiologia , Neoplasias Bucais/metabolismo , Lesões Pré-Cancerosas/etiologia , Lesões Pré-Cancerosas/metabolismo , Saliva/metabolismo , Oligoelementos/metabolismo , Biomarcadores , Estudos de Casos e Controles , Cobre , Estudos Transversais , Humanos , Ferro , Leucoplasia Oral/etiologia , Leucoplasia Oral/metabolismo , Leucoplasia Oral/patologia , Neoplasias Bucais/patologia , Lesões Pré-Cancerosas/patologia , Saliva/química , Oligoelementos/química , Zinco
18.
Asian Pac J Cancer Prev ; 16(4): 1515-8, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25743823

RESUMO

BACKGROUND: Leukoplakia is an asymptomatic and potentially malignant change in the oral mucosa and high frequencies have been reported among smokers. The present study concerned the prevalence of tobacco use and leukoplakia and also associations between the two. STUDY DESIGN: This cross sectional survey was conducted amongst the Gond tribal population of Kundam Block, Jabalpur district, Madhya Pradesh state, Central India during 2007 to 2009. Screening for leukoplakia was conducted by a medical officer with two mouth mirrors. It is only based on visual inspection and oral pathology was not performed. A semi-structured questionnaire was used to collect information on socio-demographic and smoking habits. Prevalence of leukoplakia among users and non-users of tobacco was calculated in terms of percentages. RESULTS: Of 1,552 individuals aged more than 12 years of age who were screened, 144 (9.3%) were found to have oral leukoplakia. The prevalence of leukoplakia was significantly elevated among tobacco users as compared to non-users (11% vs 2.5%; p<0.001). The percentage of leukoplakia was almost similar in both tobacco smokers and chewers (9% vs 11%; p=0.304). However, the percentage of leukoplakia was especially high among those chewers who also smoked tobacco (21.9%). CONCLUSIONS: The findings of the present study showed a positive effect of tobacco use and prevalence of leukoplakia. Also the prevalence was very high among Gond tribe, a marginalized population living in central India. There is a need for effective screening and treatment of leukoplakia in this area.


Assuntos
Leucoplasia Oral/epidemiologia , Leucoplasia Oral/etiologia , Fumar/efeitos adversos , Fumar/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Consumo de Bebidas Alcoólicas/efeitos adversos , Criança , Estudos Transversais , Feminino , Seguimentos , Humanos , Índia/epidemiologia , Masculino , Pessoa de Meia-Idade , Prevalência , Prognóstico , Adulto Jovem
19.
Asian Pac J Cancer Prev ; 16(18): 8365-70, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26745086

RESUMO

BACKGROUND: Shammah is a traditional form of snuff dipping tobacco (a smokeless tobacco form) that is commonly used in Yemen. Oral mucosal changes due to the use of shammah can usually be observed in the mucosal surfaces that the product touches. The aim of this study was to determine the association between shammah use and oral leukoplakia-like lesions. Other associated factors were also determined. MATERIALS AND METHODS: A cross sectional study was conducted on 346 randomly selected adult males. Multi-stage random sampling was used to select the study location. After completing the structured questionnaire interviews, all the participants underwent clinical exanimation for screening of oral leukoplakia-like lesions Clinical features of oral leukoplakia-like lesion were characterized based on the grades of Axell et al (1976). Univariable logistic regression and multivariable logistic regression were used to assess the potential associated factors. RESULTS: Out of 346 male participants aged 18 years and older, 68 (19.7%) reported being current shammah users. The multivariable analysis revealed that age, non-formal or primary level of education, former shammah user, current shammah user, and frequency of shammah use per day were statistically associated with the presence of oral leukoplakia-like lesions [Adjusted odds ratio (AOR) = 1.03; 95% confidence interval (CI) : 1.01, 1.06; P= 0.006], (AOR= 8.65; 95% CI: 2.81, 26.57; P= 0.001), (AOR= 3.65; 95% CI: 1.40, 9.50; P= 0.008), (AOR= 12.99; 95% CI: 6.34, 26.59; P= 0.001), and (AOR= 1.17; 95% CI: 1.02, 1.36; P= 0.026), respectively. CONCLUSIONS: The results revealed oral leukoplakia-like lesions to be significantly associated with shammah use. Therefore, it is important to develop comprehensive shammah prevention programs in Yemen.


Assuntos
Leucoplasia Oral/etiologia , Neoplasias Bucais/etiologia , Tabagismo/etiologia , Tabaco sem Fumaça/efeitos adversos , Adolescente , Adulto , Idoso , Estudos Transversais , Seguimentos , Humanos , Leucoplasia Oral/epidemiologia , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/epidemiologia , Prognóstico , Inquéritos e Questionários , Tabagismo/epidemiologia , Iêmen/epidemiologia , Adulto Jovem
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