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1.
BMC Musculoskelet Disord ; 23(1): 426, 2022 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-35524293

RESUMO

BACKGROUND: Notch volume is associated with anterior cruciate ligament (ACL) injury. Manual tracking of intercondylar notch on MR images is time-consuming and laborious. Deep learning has become a powerful tool for processing medical images. This study aims to develop an MRI segmentation model of intercondylar fossa based on deep learning to automatically measure notch volume, and explore its correlation with ACL injury. METHODS: The MRI data of 363 subjects (311 males and 52 females) with ACL injuries incurred during non-contact sports and 232 subjects (147 males and 85 females) with intact ACL were retrospectively analyzed. Each layer of intercondylar fossa was manually traced by radiologists on axial MR images. Notch volume was then calculated. We constructed an automatic segmentation system based on the architecture of Res-UNet for intercondylar fossa and used dice similarity coefficient (DSC) to compare the performance of segmentation systems by different networks. Unpaired t-test was performed to determine differences in notch volume between ACL-injured and intact groups, and between males and females. RESULTS: The DSCs of intercondylar fossa based on different networks were all more than 0.90, and Res-UNet showed the best performance. The notch volume was significantly lower in the ACL-injured group than in the control group (6.12 ± 1.34 cm3 vs. 6.95 ± 1.75 cm3, P < 0.001). Females had lower notch volume than males (5.41 ± 1.30 cm3 vs. 6.76 ± 1.51 cm3, P < 0.001). Males and females who had ACL injuries had smaller notch than those with intact ACL (p < 0.001 and p < 0.005). Men had larger notches than women, regardless of the ACL injuries (p < 0.001). CONCLUSION: Using a deep neural network to segment intercondylar fossa automatically provides a technical support for the clinical prediction and prevention of ACL injury and re-injury after surgery.


Assuntos
Lesões do Ligamento Cruzado Anterior , Aprendizado Profundo , Ligamento Cruzado Anterior/cirurgia , Lesões do Ligamento Cruzado Anterior/diagnóstico por imagem , Lesões do Ligamento Cruzado Anterior/cirurgia , Feminino , Fêmur/cirurgia , Humanos , Articulação do Joelho/diagnóstico por imagem , Articulação do Joelho/cirurgia , Imageamento por Ressonância Magnética/métodos , Masculino , Estudos Retrospectivos
2.
Parasit Vectors ; 15(1): 105, 2022 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-35534857

RESUMO

BACKGROUND: Cranial cruciate ligament rupture (CCLR) results from a multifactorial degenerative process that leads to rupture of the ligament. Vector-borne pathogens (VBP) in dogs can induce joint disease but their role in CCLR has not been previously investigated. The aim of the present work is to evaluate the prevalence of VBP in dogs with CCLR. METHODS: This was a prospective study that included 46 dogs presented for CCLR surgical treatment and 16 control dogs euthanized for diseases unrelated to the joints. Specimens collected included blood, synovial fluid, and synovial membrane biopsy. Pathogen testing consisted of serology for Leishmania infantum (quantitative ELISA), Ehrlichia canis/ewingii, Borrelia burgdorferi, Anaplasma phagocytophilum/platys, and Dirofilaria immitis (4DX IDEXX test), and PCR for L. infantum, Ehrlichia/Anaplasma spp., Bartonella spp., piroplasms (Babesia spp. and Theileria spp.), and filariae (D. immitis, Dirofilaria repens, Acanthocheilonema dracunculoides, Acanthocheilonema reconditum, and Cercopithifilaria spp.) on both EDTA-whole blood (EB) and synovial fluid (SF) samples. SF cytology and histopathological evaluation of synovial membrane were also performed. RESULTS: The prevalence of VBP was 19.6% in the CCLR group and 18.8% in the control group, with no statistical difference among them. The presence of synovitis was not more frequent in CCLR dogs (45.6%) than in control dogs (43.7%). Lymphoplasmacytic infiltration was the most common inflammatory pattern detected in the joints of both groups of dogs. CONCLUSIONS: This study failed to demonstrate a role of canine VBP in CCLR or the presence or different pattern of joint inflammation in pathogen-positive dogs.


Assuntos
Anaplasmose , Dirofilaria immitis , Doenças do Cão , Ehrlichiose , Anaplasma/genética , Anaplasmose/epidemiologia , Animais , Ligamento Cruzado Anterior , Doenças do Cão/epidemiologia , Cães , Ehrlichia , Ehrlichiose/veterinária , Estudos Prospectivos , Estudos Soroepidemiológicos
3.
J Orthop Surg Res ; 17(1): 250, 2022 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-35505440

RESUMO

BACKGROUND: Anterior cruciate ligament plays a significant role in knee joint stability. It is claimed that the incidence of knee osteoarthritis increases in individuals with anterior cruciate ligament (ACL) rupture. The aim of this study was to evaluate the knee joints reaction force in ACL rupture group compared to normal subjects. METHOD: Fifteen patients with acute ACL rupture and 15 healthy subjects participated in this study. The ground reaction force (GRF) and kinematic data were collected at a sampling rate of 120 Hz during level-ground walking. Spatiotemporal parameters, joint angles, muscle forces and moments, and joint reaction force (JRF) of lower extremity were analyzed by OpenSIM software. RESULTS: The hip, knee and ankle joints reaction force at loading response and push-off intervals of the stance phase during walking was significantly higher in individuals with ACL rupture compared to healthy controls (p value < 0.05). Walking velocity (p value < 0.001), knee (p value = 0.065) and ankle (p value = 0.001) range of motion in the sagittal plane were significantly lower in the patients with ACL rupture compared to healthy subjects. The mean value of vertical GRF in the mid-stance, the peak of the hip adduction moment in loading response and push-off phases, the hip abductor, knee flexor and vastus intermedius part of quadriceps muscle forces were significantly higher compared to healthy subjects (p < 0.05) while vastus medialis and vastus lateralis produced significantly lower force (p < 0.001). CONCLUSIONS: Based on results of this study, lower limb JRF was higher in those with ACL rupture compared to healthy subjects may be due to the compensatory mechanisms used by this group of subjects. An increase in knee JRF in patients with ACL rupture may be the reason for the high incidence of knee OA.


Assuntos
Lesões do Ligamento Cruzado Anterior , Ligamento Cruzado Anterior , Ligamento Cruzado Anterior/fisiologia , Marcha/fisiologia , Humanos , Articulação do Joelho/fisiologia , Caminhada/fisiologia
4.
Arthroscopy ; 38(5): 1535-1536, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35501018

RESUMO

Soaking anterior cruciate ligament grafts in vancomycin solution is done by many surgeons. Research has indicated decreased infection rates and similar anterior cruciate ligament retear rates between grafts soaked in vancomycin solution before implantation versus those without. In addition, there has been basic science evidence for tenocyte survival and viability even when exposed to vancomycin solution. The next frontier, investigating the maturation of vancomycin-soaked grafts with advanced imaging, may cause some surgeons to reconsider the practice but should not stop it, based on the available literature.


Assuntos
Lesões do Ligamento Cruzado Anterior , Reconstrução do Ligamento Cruzado Anterior , Ligamento Cruzado Anterior/transplante , Lesões do Ligamento Cruzado Anterior/cirurgia , Reconstrução do Ligamento Cruzado Anterior/métodos , Humanos , Vancomicina/farmacologia , Vancomicina/uso terapêutico
5.
Arthroscopy ; 38(5): 1595-1596, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35501023

RESUMO

Graft selection in anterior cruciate ligament reconstruction can have a pivotal role in a successful outcome. One of the major concerns with hamstring autograft is the variability of the diameter of each tendon, and grafts with a diameter of less than 8 mm may result in an increased failure rate. The addition of the sartorius tendon as a fifth strand in small-diameter hamstring autografts increases graft strength and diameter. This may improve outcomes in pediatric and revision cases.


Assuntos
Lesões do Ligamento Cruzado Anterior , Reconstrução do Ligamento Cruzado Anterior , Ligamento Cruzado Anterior/cirurgia , Lesões do Ligamento Cruzado Anterior/cirurgia , Autoenxertos , Criança , Humanos , Tendões/transplante
6.
Arthroscopy ; 38(5): 1605-1607, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35501024

RESUMO

Risk for anterior cruciate ligament (ACL) injury is greater in female than in male patients for a myriad of reasons, with osseous anatomy about the knee proving to be one significant risk factor for ACL injury and/or ACL graft failure. While femoral intercondylar notch size/shape and posterior tibial slope have been well-examined in this regard for their contribution to potential ACL injury, morphology of the lateral femoral condyle is a newer entity that may be linked to risk for ACL injury. Smaller/stenotic femoral intercondylar notches, increased posterior tibial slope of the lateral tibial plateau, and increased posterior condylar depth of the lateral femoral condyle have all been shown to increase risk for ACL injury and/or ACL graft failure. Such associations provide knee surgeons with food for thought when considering procedures such as notchplasty, staged anterior closing wedge high tibial osteotomy, and anterolateral ligament reconstruction/augmentation at the time of primary or revision ACL reconstruction. Further investigation into the links between pre-operative imaging parameters and outcomes following such concomitant procedures is required in order for any significant conclusions to be drawn.


Assuntos
Lesões do Ligamento Cruzado Anterior , Ligamento Cruzado Anterior , Ligamento Cruzado Anterior/cirurgia , Lesões do Ligamento Cruzado Anterior/cirurgia , Feminino , Humanos , Articulação do Joelho/anatomia & histologia , Articulação do Joelho/diagnóstico por imagem , Articulação do Joelho/cirurgia , Masculino , Fatores de Risco , Tíbia/anatomia & histologia , Tíbia/cirurgia
8.
Sci Rep ; 12(1): 6647, 2022 Apr 22.
Artigo em Inglês | MEDLINE | ID: mdl-35459787

RESUMO

Anterior cruciate ligament (ACL) deficient and reconstructed knees display altered biomechanics during gait. Identifying significant gait changes is important for understanding normal and ACL function and is typically performed by statistical approaches. This paper focuses on the development of an explainable machine learning (ML) empowered methodology to: (i) identify important gait kinematic, kinetic parameters and quantify their contribution in the diagnosis of ACL injury and (ii) investigate the differences in sagittal plane kinematics and kinetics of the gait cycle between ACL deficient, ACL reconstructed and healthy individuals. For this aim, an extensive experimental setup was designed in which three-dimensional ground reaction forces and sagittal plane kinematic as well as kinetic parameters were collected from 151 subjects. The effectiveness of the proposed methodology was evaluated using a comparative analysis with eight well-known classifiers. Support Vector Machines were proved to be the best performing model (accuracy of 94.95%) on a group of 21 selected biomechanical parameters. Neural Networks accomplished the second best performance (92.89%). A state-of-the-art explainability analysis based on SHapley Additive exPlanations (SHAP) and conventional statistical analysis were then employed to quantify the contribution of the input biomechanical parameters in the diagnosis of ACL injury. Features, that would have been neglected by the traditional statistical analysis, were identified as contributing parameters having significant impact on the ML model's output for ACL injury during gait.


Assuntos
Lesões do Ligamento Cruzado Anterior , Ligamento Cruzado Anterior , Lesões do Ligamento Cruzado Anterior/diagnóstico , Fenômenos Biomecânicos , Marcha , Humanos , Articulação do Joelho , Aprendizado de Máquina
9.
Comput Math Methods Med ; 2022: 2915157, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35465002

RESUMO

Objective: To explore the effect of nursing in operating room combined with intraoperative heat preservation intervention on preventing incision infection and improving hemodynamics in patients with anterior cruciate ligament (ACL) injury and reconstruction under knee arthroscopy. Methods: About 200 patients with knee arthroscopic ACL reconstruction in our hospital from January 2019 to July 2021 were enrolled. The patients were randomly assigned into two groups: the control group and the study group. The former group received nursing care in the operating room operating room and the latter group received nursing care in operating room combined with intraoperative heat preservation intervention. Nursing satisfaction, incidence of incision infection, knee joint VAS score, knee joint range of motion, knee joint Lysholm score, and hemodynamic indexes were compared. Results: First of all, we compared the nursing satisfaction, the study group was very satisfied in 78 cases, satisfactory in 20 cases, and general in 2 cases, and the satisfaction rate was 100.00%, while in the control group, 445 cases were very satisfied, 20 cases were satisfied, 15 cases were general, and 8 cases were dissatisfied. The satisfaction rate was 82.00%. The nursing satisfaction of the study group was higher compared to the control group (P < 0.05). Secondly, we compared the incidence of incision infection. The incidence of incision infection in the study group was lower compared to the control group (P < 0.05). With regard to the knee joint VAS score, the knee joint VAS score of the study group was lower compared to the control group at 2 weeks, 4 weeks, 8 weeks, and 12 weeks after operation (P < 0.05). In terms of the range of motion of the knee joint, the range of motion of the knee joint in the study group was higher compared to the control group at 2 weeks, 4 weeks, 8 weeks, and 12 weeks after operation (P < 0.05). Regarding the knee joint Lysholm score, the knee joint Lysholm score of the study group was higher compared to the control group at 2 weeks, 4 weeks, 8 weeks, and 12 weeks after operation (P < 0.05). Finally, we compared the hemodynamic indexes. Before nursing, there exhibited no significant difference (P > 0.05). During and after nursing, the indexes of HR and MAP in the study group fluctuated little (P < 0.05). Conclusion: During the perioperative period of patients with ACL injury and reconstruction under knee arthroscopy, standardized and necessary operating room combined with intraoperative thermal insulation intervention measures should be given, attention should be paid to the management of operating room, and intraoperative thermal insulation intervention should be strengthened. It includes preoperative visit, psychological nursing of patients, strict application of antibiotics before operation, monitoring of air quality in operating room, disinfection and sterilization of surgical instruments, shortening operation time, maintaining body temperature during operation, and paying attention to hand hygiene of medical staff. It plays a supervisory role in promoting the attention of medical staff to the prevention of wound infection, which is beneficial to the healing of surgical wounds of patients. It plays a positive role in enhancing hemodynamic indexes. Comprehensive nursing intervention on the risk factors of each link can effectively prevent postoperative wound infection and strengthen the prognosis and quality of life of patients.


Assuntos
Lesões do Ligamento Cruzado Anterior , Ligamento Cruzado Anterior/cirurgia , Lesões do Ligamento Cruzado Anterior/cirurgia , Artroscopia , Hemodinâmica , Temperatura Alta , Humanos , Articulação do Joelho/cirurgia , Salas Cirúrgicas , Qualidade de Vida , Infecção da Ferida Cirúrgica , Resultado do Tratamento
10.
J Healthc Eng ; 2022: 2550120, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35444781

RESUMO

In recent times, knee joint pains have become severe enough to make daily tasks difficult. Knee osteoarthritis is a type of arthritis and a leading cause of disability worldwide. The middle of the knee contains a vital portion, the anterior cruciate ligament (ACL). It is necessary to diagnose the ACL ruptured tears early to avoid surgery. The study aimed to perform a comparative analysis of machine learning models to identify the condition of three ACL tears. In contrast to previous studies, this study also considers imbalanced data distributions as machine learning techniques struggle to deal with this problem. The paper applied and analyzed four machine learning classification models, namely, random forest (RF), categorical boosting (Cat Boost), light gradient boosting machines (LGBM), and highly randomized classifier (ETC) on the balanced, structured dataset of ACL. After oversampling a hyperparameter adjustment, the above four models have achieved an average accuracy of 95.72%, 94.98%, 94.98%, and 98.26%. There are 2070 observations and eight features in the collection of three diagnosis ACL classes after oversampling. The area under curve value was approximately 0.998, respectively. Experiments were performed using twelve machine learning algorithms with imbalanced and balanced datasets. However, the accuracy of the imbalanced dataset has remained under 76% for all twelve models. After oversampling, the proposed model may contribute to the investigation of ACL tears on magnetic resonance imaging and other knee ligaments efficiently and automatically without involving radiologists.


Assuntos
Lesões do Ligamento Cruzado Anterior , Ligamento Cruzado Anterior/diagnóstico por imagem , Lesões do Ligamento Cruzado Anterior/diagnóstico por imagem , Humanos , Joelho/diagnóstico por imagem , Articulação do Joelho/diagnóstico por imagem , Aprendizado de Máquina , Imageamento por Ressonância Magnética/métodos
11.
Ulus Travma Acil Cerrahi Derg ; 28(3): 320-327, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35485559

RESUMO

BACKGROUND: Generalized joint hypermobility (GJH) is a risk factor for anterior cruciate ligament (ACL) injury and ACL graft failure and is considered an indication for anterolateral ligament (ALL) reconstruction. The aim of this retrospective study was to compare functional outcomes, rupture rates, and residual instability in patients with GJH undergoing isolated ACL reconstruction or combined ACL reconstruction and ALL augmentation with internal bracing (ALL-IB). METHODS: Sixty-eight patients with GJH and unilateral ACL injury were randomly assigned to undergo either isolated ACL reconstruction (Group 1) or combined ACL reconstruction and ALL-IB (Group 2). The patients were evaluated pre- and postoperatively; their medical histories; physical examination results; anterior knee translation, as measured using the KT-1000 arthrometer; and scores of validated knee assessments were recorded. RESULTS: Groups 1 and 2 consisted of 37 and 31 patients, respectively. The mean follow-up was 30.1±4.1 and 28.1±2.9 months, respectively. In the final evaluation, the patients in Group 2 showed better rotational stability, as evaluated by the pivot-shift test (p=0.013); better anteroposterior stability, as evaluated by KT-1000 arthrometry (p=0.001); similar function (p=0.14 for the Lysholm, p=0.11 for the Cincinnati, and p=0.19 for the International Knee Documentation Committee subjective score); and failure rate (p=0.41). CONCLUSION: The functional outcomes were similar between the groups. The stability outcomes after combined ACL and ALL-IB were better than those after isolated ACL reconstruction in patients with GJH. However, the technique and its results need to be validated in larger patient series and prospective randomized controlled trials.


Assuntos
Lesões do Ligamento Cruzado Anterior , Reconstrução do Ligamento Cruzado Anterior , Instabilidade Articular , Ligamento Cruzado Anterior/cirurgia , Lesões do Ligamento Cruzado Anterior/cirurgia , Reconstrução do Ligamento Cruzado Anterior/métodos , Humanos , Instabilidade Articular/cirurgia , Estudos Prospectivos , Estudos Retrospectivos
12.
Sci Rep ; 12(1): 6844, 2022 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-35477722

RESUMO

Knowledge of the anatomy of the anterior cruciate ligament (ACL) is important to understand the function and pathology of the knee joint. However, on the tibial side of ACL, its structural relationships with the articular cartilage and lateral meniscus remain unclear. Furthermore, conventional research methods are limited to analyzing the bone attachments. We provide a comprehensive, three-dimensional anatomical description of the tibial side of the ACL that questions the principle that "a ligament is necessarily a structure connecting a bone to another bone." In our study, 11 knees from 6 cadavers were used for macroscopic anatomical examinations, serial-section histological analyses, and three-dimensional reconstructions. The attachments of the tibial side of ACL consisted of attachments to the bone (102.6 ± 27.5 mm2), articular cartilage (40.9 ± 13.6 mm2), and lateral meniscus (6.5 ± 4.6 mm2), suggesting that the ACL has close structural relationships with the articular cartilage and lateral meniscus. Our study demonstrates that the tibial side of the ACL is not attached to the bone surface only and provides new perspectives on ligamentous attachments. Considering its attachment to the articular cartilage would enable more accurate functional evaluations of the mechanical tensioning of the ACL.


Assuntos
Ligamento Cruzado Anterior , Cartilagem Articular , Ligamento Cruzado Anterior/patologia , Articulação do Joelho/anatomia & histologia , Meniscos Tibiais/anatomia & histologia , Tíbia/patologia
13.
BMC Musculoskelet Disord ; 23(1): 383, 2022 Apr 25.
Artigo em Inglês | MEDLINE | ID: mdl-35468775

RESUMO

BACKGROUND: Several studies have shown persistent postural control deficits and rotatory instability in patients after isolated Anterior Cruciate Ligament (ACL) reconstruction. There is evidence to support that the Anterolateral Ligament (ALL) plays an important role in the remaining anterolateral rotatory laxity of the knee. There are no further evidences in order to understand how patients with a combined ACL + ALL reconstruction surgery indication behave regarding postural control. The aim of this cross-sectional study was to assess if patients with a clinical indication for the combined ACL + ALL surgery showed a deficient postural control in single leg stance compared to subjects with a regular ACL reconstruction indication and to a control group. METHODS: An assessment of static postural control on single leg stance was performed on a force plate, with eyes open and closed, and the center of pressure (COP) displacement variables were analyzed: maximum and mean amplitude in anteroposterior (AP) and in mediolateral (ML) direction; mean velocity of displacement and area of displacement. Eighty-nine male individuals participated and were divided into 3 groups: ACL Group, ACL + ALL Group and Control Group. RESULTS: The ACL+ ALL Group showed significantly greater COP displacement in most variables in the injured leg for the eyes closed test, compared to the ACL Group, as detailed: Total ML displacement (9.8 ± 6.77 vs. 13.98 ± 6.64, p < 0.001); Mean ML displacement (2.58 ± 2.02 vs. 3.72 ± 1.99, p < 0.001); Total AP displacement (9.5 ± 3.97 vs. 11.7 ± 3.66, p = 0.001); Mean AP displacement (1.77 ± 0.87 vs. 2.27 ± 0.86, p = 0.001); Area of displacement (111.44 ± 127.3 vs. 183.69 ± 131.48, p < 0.001). CONCLUSION: Subjects with a clinical indication for ACL + ALL combined reconstruction surgery showed increased COP displacement compared to patients with indication for an ACL isolated reconstruction surgery.


Assuntos
Lesões do Ligamento Cruzado Anterior , Instabilidade Articular , Ligamento Cruzado Anterior/cirurgia , Lesões do Ligamento Cruzado Anterior/diagnóstico , Lesões do Ligamento Cruzado Anterior/cirurgia , Estudos Transversais , Humanos , Instabilidade Articular/cirurgia , Articulação do Joelho/cirurgia , Perna (Membro) , Masculino , Equilíbrio Postural
14.
Sci Rep ; 12(1): 6751, 2022 Apr 25.
Artigo em Inglês | MEDLINE | ID: mdl-35468916

RESUMO

There is an essential demand for developing biocompatible grafts for knee anterior cruciate ligament reconstruction (ACLR). This study investigated cell infiltration into decellularized bovine tendon xenografts using a rat knee ACLR model. Twelve-week-old Sprague-Dawley rats were used. At weeks 1, 2, 4, 8, 16, 26, and 52 (each period, n = 6) after ACLR, rats receiving decellularized bovine tendon (group D, n = 42) or autologous tendon (group A, n = 42) as grafts underwent peritibial bone tunnel bone mineral density (BMD), histological, and immunohistological assessments. BMD increased over time in both the groups until week 16 and then remained unchanged without exhibiting significant differences between the groups. Initially, cellularity in group D was lower than that in group A; however, by weeks 4-8, both the groups were comparable to the native anterior cruciate ligament group and cellularity remained unchanged until week 52. Initially, group A had more M1 macrophages, indicating inflammation, whereas group D had more M2 macrophages, indicating tissue regeneration. Nonetheless, the M1 and M2 macrophage counts of both the groups were comparable at most times. This study revealed the excellent recellularization and tendon-bone integration abilities of decellularized tendons using a cross-species model.


Assuntos
Reconstrução do Ligamento Cruzado Anterior , Animais , Ligamento Cruzado Anterior/cirurgia , Autoenxertos , Bovinos , Humanos , Ratos , Ratos Sprague-Dawley , Tendões/cirurgia
15.
Knee ; 35: 192-200, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35366618

RESUMO

BACKGROUND: Primary repair of anterior cruciate ligament (ACL) ruptures has re-emerged as a treatment option for proximal tears, with internal brace augmentation often utilised. The aim of this study is to provide an overview of the current evidence presenting outcomes of ACL repair with internal bracing to assess the safety and efficacy of this technique. METHODS: All studies reporting outcomes of arthroscopic primary repair of proximal ACL tears, augmented with internal bracing from 2014-2021 were included. Primary outcome was failure rate and secondary outcomes were subjective patient reported outcome measures (PROMs) and objective assessment of anteroposterior knee laxity. RESULTS: Nine studies were included, consisting of 347 patients, mean age 32.5 years, mean minimum follow up 2 years. There were 36 failures (10.4%, CI 7.4% - 14.1%). PROMs reporting was variable across studies. KOOS, Lysholm and IKDC scores were most frequently used with mean scores > 87%. The mean Tegner and Marx scores at follow-up were 6.1 and 7.8 respectively. The mean side to side difference measured for anteroposterior knee laxity was 1.2mm. CONCLUSIONS: This systematic review with meta-analysis shows that ACL repair with internal bracing is a safe technique for treatment of proximal ruptures, with a failure rate of 10.4%. Subjective scores and clinical laxity testing also revealed satisfactory results. This suggests that ACL repair with internal bracing should be considered as an alternative to ACL reconstruction for acute proximal tears, with the potential benefits of retained native tissue and proprioception, as well as negating the need for graft harvest.


Assuntos
Lesões do Ligamento Cruzado Anterior , Reconstrução do Ligamento Cruzado Anterior , Adulto , Ligamento Cruzado Anterior/cirurgia , Lesões do Ligamento Cruzado Anterior/cirurgia , Reconstrução do Ligamento Cruzado Anterior/métodos , Seguimentos , Humanos , Articulação do Joelho/cirurgia , Resultado do Tratamento
16.
J Biomech ; 136: 111069, 2022 May.
Artigo em Inglês | MEDLINE | ID: mdl-35381503

RESUMO

Advancements in technology and finite element software have made it possible to develop simulation-based exploration of subject-specific tibiofemoral joint kinematics. In this study, the goal was to develop baseline knee models that accurately predict anterior tibial displacement when undergoing a Lachman and pivot shift test. A total of 22 subject-specific adolescent tibiofemoral joint finite element representations were developed using FEBio. The models were subject to loading conditions established in the literature to simulate the two clinical tests. Anterior tibial translations that were measured through clinical, historical controls were used to validate the proposed models. A 95% confidence interval showed that the simulated Lachman and pivot shift tests of the juvenile knee models were not statistically different from the historical controls and were in accordance with the anterior tibial translations that were measured experimentally. Clinically, simulations are important in advancing the field of knee finite element modeling, particularly in pediatric applications where the surgeon must balance restoring full function in a patient who is skeletally immature and where the growth plate is vulnerable. The methodologies created in developing these foundational models can be utilized to build more anatomically complex finite element representations that can both predict ligament stresses in response to dynamic activities and analyze the effects of different insertion sites.


Assuntos
Lesões do Ligamento Cruzado Anterior , Instabilidade Articular , Adolescente , Ligamento Cruzado Anterior/fisiologia , Fenômenos Biomecânicos/fisiologia , Cadáver , Criança , Humanos , Articulação do Joelho/fisiologia , Amplitude de Movimento Articular/fisiologia , Rotação
17.
J Athl Train ; 57(4): 325-333, 2022 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-35439312

RESUMO

CONTEXT: Return-to-activity (RTA) assessments are commonly administered after anterior cruciate ligament reconstruction (ACLR) to manage the patient's postoperative progressions back to activity. To date, few data are available on the clinical utility of these assessments to predict patient outcomes such as secondary anterior cruciate ligament (ACL) injury once the athlete has returned to activity. OBJECTIVE: To identify the measures of patient function at 6 months post-ACLR that best predict RTA and second ACL injury at a minimum of 2 years after ACLR. DESIGN: Prospective cohort study. SETTING: Laboratory. PATIENTS OR OTHER PARTICIPANTS: A total of 234 patients with primary, unilateral ACLR completed functional assessments at approximately 6 months post-ACLR. Of these, 192 (82.1%) completed follow-up at ≥2 years post-ACLR. MAIN OUTCOME MEASURE(S): The 6-month functional assessments consisted of patient-reported outcomes, isokinetic knee-flexor and -extensor strength, and single-legged hopping. We collected RTA and secondary ACL injury data at ≥2 years after ACLR. RESULTS: Of the patients who were able to RTA (n = 155), 44 (28.4%) had a subsequent ACL injury, 24 (15.5%) to the ipsilateral graft ACL and 20 (12.9%) to the contralateral ACL. A greater proportion of females had a secondary injury to the contralateral ACL (15/24, 62.5%), whereas a greater proportion of males reinjured the ipsilateral ACL graft (15/20, 75.0%; P = .017). Greater knee-extension symmetry at 6 months increased the probability of reinjury (B = 0.016, P = .048). Among patients with RTA at <8 months, every 1% increase in quadriceps strength symmetry at 6 months increased the risk of reinjury by 2.1% (B = 0.021, P = .05). Among patients with RTA at >8 months, every month that RTA was delayed reduced the risk of reinjury by 28.4% (B = -0.284, P = .042). Descriptive statistics of patient function stratified between the early and delayed RTA groups can be found in the Supplemental Table (available online at http://dx.doi.org/10.4085/1062-6050-0407.20.S1). CONCLUSIONS: Patients with more symmetric quadriceps strength at 6 months post-ACLR were more likely to experience another ACL rupture, especially those who returned to sport at <8 months after the index surgery. Clinicians should be cognizant that returning high-functioning patients to activity at <8 months post-ACLR may place them at an increased risk for reinjury.


Assuntos
Lesões do Ligamento Cruzado Anterior , Relesões , Ligamento Cruzado Anterior , Lesões do Ligamento Cruzado Anterior/cirurgia , Feminino , Humanos , Masculino , Força Muscular , Estudos Prospectivos , Músculo Quadríceps , Volta ao Esporte
18.
Int J Mol Sci ; 23(8)2022 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-35457148

RESUMO

Exceeded mechanical stress leads to a sublethal injury to anterior cruciate ligament (ACL) fibroblasts, and it will hinder cell mobility and ACL regeneration, and even induce osteoarthritis. The mechano growth factor (MGF) could be responsible for mechanical stress and weakening its negative effects on cell physiological behaviors. In this study, effects of MGF on cell mobility and relevant molecules expression in injured ACL fibroblasts were detected. After an injurious mechanical stretch, the analysis carried out, at 0 and 24 h, respectively, showed that the cell area, roundness, migration, and adhesion of ACL fibroblasts were reduced. MGF (10, 100 ng/mL) treatment could improve cell area, roundness and promote cell migration and adhesion capacity compared with the injured group without MGF. Further study indicated that cell mobility-relevant molecules (PAK1/2, Cdc42, Rac1, RhoA, and ROCK1) expression in ACL fibroblasts was down-regulated at 0 or 24 h after injurious stretch (except Rac1 and RhoA at 0 h). Similarly, MGF improved cell mobility-relevant molecule expression, especially the ROCK1 expression level in ACL fibroblasts at 0 or 24 h after injurious stretch. Protein expression of ROCK1 in injured ACL fibroblasts was also reduced and could be recovered by MGF treatment. In a rabbit partial ACL transection (ACLT) model, ACL exhibited poor regenerative capacity in collagen and extracellular matrix (ECM) synthesis after partial ACLT for 2 or 4 weeks, and MGF remarkably accelerated ACL regeneration and restored its mechanical loading capacity after partial ACLT for four weeks. Our findings suggest that MGF weakens the effects of pathological stress on cell mobility of ACL fibroblasts and accelerates ACL repair, and might be applied as a future treatment approach to ACL rupture in the clinic.


Assuntos
Lesões do Ligamento Cruzado Anterior , Ligamento Cruzado Anterior , Animais , Lesões do Ligamento Cruzado Anterior/metabolismo , Movimento Celular , Colágeno/metabolismo , Fibroblastos/metabolismo , Humanos , Coelhos , Quinases Ativadas por p21/metabolismo , Proteínas rac1 de Ligação ao GTP/metabolismo , Quinases Associadas a rho/metabolismo , Proteína rhoA de Ligação ao GTP/metabolismo
20.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi ; 36(4): 495-499, 2022 Apr 15.
Artigo em Chinês | MEDLINE | ID: mdl-35426291

RESUMO

Objective: To summarize the current management of anterior cruciate ligament (ACL) injury in children and adolescents, in order to provide reference for the management of ACL injury in children and adolescents. Methods: The relevant literature at home and abroad in recent years was extensively accessed to summarize the management status of ACL injury in children and adolescent. Results: The number of ACL injury in children and adolescents is increasing every year. The diagnosis of ACL mainly depends on symptoms and signs. Rehabilitation, physeal-sparing techniques, partial transphyseal techniques, all-epiphyseal techniques, and transphyseal techniques are used to treat ACL injury in children and adolescents. Conclusion: Dynamic monitoring of knee joint in children and adolescents should be strengthened. The best treatment for ACL injury in children and adolescents is selected according to the patients' actual age, bone age, Tanner stage, and physiological conditions such as menstruation, body growth speed, and other characteristics.


Assuntos
Lesões do Ligamento Cruzado Anterior , Reconstrução do Ligamento Cruzado Anterior , Adolescente , Ligamento Cruzado Anterior/cirurgia , Lesões do Ligamento Cruzado Anterior/cirurgia , Reconstrução do Ligamento Cruzado Anterior/métodos , Criança , Epífises/cirurgia , Feminino , Humanos , Articulação do Joelho/cirurgia
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