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1.
Einstein (Sao Paulo) ; 18: eAO5225, 2020.
Artigo em Inglês, Português | MEDLINE | ID: mdl-32578676

RESUMO

OBJECTIVE: To analyze the latency and the amplitude values of Mismatch Negativity and P300 cognitive potential in children with stuttering, with no auditory complaints, with auditory thresholds within the normality range, comparing them to the findings of a Control Group. METHODS: A cross-sectional study involving 50 children of both sexes, 15 with stuttering and 35 without stuttering, aged 6 to 11 years, with no diagnosis of ear pathology or other diseases. All children were submitted to peripheral audiological evaluation (meatoscopy, pure tone testing, speech audiometry, and acoustic immittance measures) and a central audiological evaluation (investigation of the Mismatch Negativity and P300 cognitive potential). For the evaluation of fluency, all children with stuttering had a specific history taken and were video recorded in a spontaneous speech. Afterwards, the transcription was done, followed by speech analysis to classify children according the severity of stuttering. RESULTS: There was a significant difference in the latencies of Mismatch Negativity and P300 cognitive potential, as well as in the amplitude of Mismatch Negativity. CONCLUSION: There was a significant delay in the latencies of Mismatch Negativity and P300 cognitive potential, as well as increase in the amplitude of the Mismatch Negativity in children with stuttering when compared to children in the Control Group. Changes in the morphology of the waves were found in the Stuttering Group.


Assuntos
Percepção Auditiva/fisiologia , Limiar Auditivo , Potenciais Evocados Auditivos/fisiologia , Gagueira/fisiopatologia , Estudos de Casos e Controles , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Tempo de Reação/fisiologia , Fala
2.
PLoS One ; 15(4): e0231632, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32324766

RESUMO

INTRODUCTION: From an epidemiological point of view, the increase of pure-tone hearing thresholds as one aspect of biological ageing is moderated by societal factors. Since health policies refer to empirical findings, it is reasonable to replicate population-based hearing surveys and to compare estimates for different birth cohorts from the same regions or, conversely, for the same birth cohorts from different regions. METHODS: We pooled data from two independent cross-sectional German studies conducted between 2008 and 2012 and including 3105 adults. The increase of thresholds, the prevalence and risk of hearing impairment (HI) by age and gender were compared to results reported for European and US-American studies that were carried out at about the same time. Since these studies differed with regard to the age limits, the statistical approaches and, importantly, their definitions of HI, data adjustments were performed to enable the comparison. RESULTS: Overall, 15.5% of the participants in the German studies showed a pure-tone average at 0.5, 1, 2, and 4 kHz in the better ear (PTA) greater than 25 dB HL and 8.6% had a PTA of at least 35 dB HL. Based on one-to-one comparisons, the German estimates demonstrated a good agreement to a large Dutch study and with some reservations to a Swedish study, but considerable differences to US-American results. Comprehensive comparisons of the within-study gender differences showed that age-related HI was less and the gender gap was markedly smaller in Europe compared to the US due to the lower HI in males found in the European studies. CONCLUSION: Discrepancies in measurement procedures, conditions, and equipment that complicate the comparison of absolute HI estimates across studies play no or only a marginal role when comparing relative estimates. Hence, the gender gap differences reviewed in this analysis possibly stem from societal conditions that distinguish societies commonly labeled modern industrialized western countries.


Assuntos
Perda Auditiva/epidemiologia , Caracteres Sexuais , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Audiometria de Tons Puros , Limiar Auditivo , Feminino , Alemanha/epidemiologia , Auxiliares de Audição , Perda Auditiva/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Estados Unidos/epidemiologia , Adulto Jovem
3.
Am J Otolaryngol ; 41(3): 102483, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32307189

RESUMO

OBJECTIVE: The current study compared the amplitude of transient evoked otoacoustic emissions (TEOAEs) and thresholds of pure-tone audiometry between asymptomatic COVID-19 PCR-positive cases and normal non-infected subjects. METHODS: Twenty cases who were confirmed positive for COVID-19 and had none of the known symptoms for this viral infection formed the test group. Their age ranged between 20 and 50 years to avoid any age-related hearing affection. Patients who had definite symptoms of COVID-19 infection as well as those who had a history of hearing loss or a history of any known cause of hearing loss were excluded from the examined sample. TEOAEs amplitude was measured for all participants. RESULTS: The high frequency pure-tone thresholds as well as the TEOAE amplitudes were significantly worse in the test group. CONCLUSIONS: COVID-19 infection could have deleterious effects on cochlear hair cell functions despite being asymptomatic. The mechanism of these effects requires further research.


Assuntos
Doenças Assintomáticas , Audiometria de Tons Puros/métodos , Limiar Auditivo/fisiologia , Infecções por Coronavirus/fisiopatologia , Perda Auditiva Neurossensorial/diagnóstico , Pneumonia Viral/fisiopatologia , Testes de Impedância Acústica/métodos , Adulto , Betacoronavirus , Estudos de Casos e Controles , Infecções por Coronavirus/epidemiologia , Surtos de Doenças , Feminino , Seguimentos , Perda Auditiva Neurossensorial/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Pandemias , Pneumonia Viral/epidemiologia , Valores de Referência , Estudos Retrospectivos , Medição de Risco , Adulto Jovem
4.
Int. arch. otorhinolaryngol. (Impr.) ; 24(1): 86-92, Jan.-Mar. 2020. tab
Artigo em Inglês | LILACS | ID: biblio-1090561

RESUMO

Abstract Introduction Spinocerebellar ataxia (SCA) is part of a genetic and clinical heteroge- neous group of neurodegenerative diseases characterized by progressive cerebellar ataxia. Objective To describe the results of audiological and electrophysiological hearing evaluations in patients with sporadic ataxia (SA). Methods A retrospective cross-sectional study was carried out with 11 patients submitted to the following procedures: anamnesis, otorhinolaryngological evaluation, tonal and vocal audiometry, acoustic immittance and brainstem auditory evoked potential (BAEP) tests. Results The patients presented with a prevalence of gait imbalance, of dysarthria, and of dysphagia; in the audiometric and BAEPs, four patients presented with alterations; in the acoustic immittance test, five patients presented with alterations, predominantly bilateral. Conclusion The most evident alterations in the audiological evaluation were the prevalence of the descending audiometric configuration between the frequencies of 2 and 4 kHz and the absence of the acoustic reflex between the frequencies of 3 and 4 kHz bilaterally. In the electrophysiological evaluation, the patients presented changes with a prevalence of increased I, III and V wave latencies and the interval in the interpeak I-III, I-V and III-V. In the present study, it was observed that auditory complaints did not have a significant prevalence in this type of ataxia, which does not occur in some types of autosomal recessive and dominant ataxia.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Audiometria de Tons Puros , Limiar Auditivo/fisiologia , Potenciais Evocados Auditivos do Tronco Encefálico , Ataxias Espinocerebelares/fisiopatologia , Testes de Impedância Acústica , Estudos Transversais , Estudos Retrospectivos , Ataxias Espinocerebelares/complicações , Transtornos da Audição/diagnóstico , Transtornos da Audição/etiologia
5.
PLoS One ; 15(3): e0230578, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32218605

RESUMO

Despite the diversity in fish auditory structures, it remains elusive how otolith morphology and swim bladder-inner ear (= otophysic) connections affect otolith motion and inner ear stimulation. A recent study visualized sound-induced otolith motion; but tank acoustics revealed a complex mixture of sound pressure and particle motion. To separate sound pressure and sound-induced particle motion, we constructed a transparent standing wave tube-like tank equipped with an inertial shaker at each end while using X-ray phase contrast imaging. Driving the shakers in phase resulted in maximised sound pressure at the tank centre, whereas particle motion was maximised when shakers were driven out of phase (180°). We studied the effects of two types of otophysic connections-i.e. the Weberian apparatus (Carassius auratus) and anterior swim bladder extensions contacting the inner ears (Etroplus canarensis)-on otolith motion when fish were subjected to a 200 Hz stimulus. Saccular otolith motion was more pronounced when the swim bladder walls oscillated under the maximised sound pressure condition. The otolith motion patterns mainly matched the orientation patterns of ciliary bundles on the sensory epithelia. Our setup enabled the characterization of the interplay between the auditory structures and provided first experimental evidence of how different types of otophysic connections affect otolith motion.


Assuntos
Sacos Aéreos/fisiologia , Ciclídeos/fisiologia , Carpa Dourada/fisiologia , Membrana dos Otólitos/fisiologia , Estimulação Acústica , Sacos Aéreos/anatomia & histologia , Sacos Aéreos/diagnóstico por imagem , Animais , Limiar Auditivo , Ciclídeos/anatomia & histologia , Carpa Dourada/anatomia & histologia , Audição/fisiologia , Processamento de Imagem Assistida por Computador , Membrana dos Otólitos/anatomia & histologia , Membrana dos Otólitos/diagnóstico por imagem , Natação , Tomografia
6.
Ann Otol Rhinol Laryngol ; 129(8): 755-766, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32146824

RESUMO

OBJECTIVES: This study examined the association between pure tone hearing sensitivity and music listening behaviors among traditional college-aged students and sought to determine factors that mediate hearing sensitivity, including health and fitness levels, gender, and personal listening device (PLD) use. METHODS: A convenience sample of college students (N = 182; 133 females, 49 males, mean age = 19.8 ± 1.4 year, average PLD use = 1.52 ± 7.1 hours•day-1) completed hearing assessments, music listening behavior questionnaires, and health and fitness tests. RESULTS: Most students listened to music at safe intensity levels (<80 dBA), though 18% had higher hearing levels (≥25 dB HL at one of the measured frequencies). Longer listening duration behavior approached but did not reach a statistical association with compromised hearing sensitivity. Of all variables measured, including cardiovascular health, fitness, and music listening, two variables: total cholesterol: triglycerides (TC:TG) and total cholesterol: high-density lipoproteins (TC:HDL) significantly associated with hearing sensitivity at 2 kHz. The odds hearing loss occurring at 4 kHz was 59% lower in females compared with males. CONCLUSION: The majority of college students had healthy music listening behavior and fitness, contributing to normal hearing sensitivity in most. In cases where greater hearing threshold levels at one or more frequencies was detected, TC:HDL and TC:TG were statistically related and at 2 kHz, males were more likely to demonstrate higher listening levels compared with females of similar health and fitness level.


Assuntos
Percepção Auditiva/fisiologia , Limiar Auditivo/fisiologia , Doenças Cardiovasculares/fisiopatologia , Nível de Saúde , Perda Auditiva Provocada por Ruído/fisiopatologia , Estudantes/psicologia , Adolescente , Adulto , Doenças Cardiovasculares/etiologia , Feminino , Perda Auditiva Provocada por Ruído/complicações , Perda Auditiva Provocada por Ruído/psicologia , Testes Auditivos , Humanos , Masculino , Inquéritos e Questionários , Adulto Jovem
7.
Codas ; 32(1): e20180139, 2020.
Artigo em Português, Inglês | MEDLINE | ID: mdl-32022219

RESUMO

PURPOSE: To establish the relationship between the performance on word recognition tasks, using words with and without sense and degree, and the configuration of hearing loss, by using Speech Inteligibility Index (SII) values as indicators, in children with hearing loss. METHODS: SII were established for 55 and 65 Decibel of Sound Pressure Level (dB SPL) input sounds of ten children presenting bilateral sensorineural hearing loss (SNHL), adapted with bilateral hearing aids, and who have oral language as the main mode of communication. The children were submitted to a word and nonsense-word repetition task of two or three intensity degrees. Their productions were analyzed according to the Word Association for Syllable Perception (WASP) Protocol. In the data analysis, the values of SII were compared with the results obtained in each analysis criterion. RESULTS: Pertaining to the words, there was statistically significant difference between the two types of stimuli in 55 dBSPL. As for the performance of consonants and point of articulation, there was a statistically significant difference between stimuli types in 65 and 55 dB SPL, and between intensities 65 and 55 dB SPL in nonsense words. CONCLUSION: Overall, there was no regularity in the relationship between hearing ability and performance in speech perception tasks. The results suggest that performance in the nonsense words recognition tasks was more related to intelligibility index than to words with meaning, possibly because it limits semantic closure strategies by the subject.


Assuntos
Auxiliares de Audição , Perda Auditiva Neurossensorial/diagnóstico , Inteligibilidade da Fala , Percepção da Fala , Estimulação Acústica/métodos , Estimulação Acústica/normas , Limiar Auditivo , Criança , Pré-Escolar , Protocolos Clínicos , Perda Auditiva Neurossensorial/reabilitação , Testes Auditivos , Humanos , Desenvolvimento da Linguagem
8.
PLoS One ; 15(1): e0227978, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31961907

RESUMO

AIM: Occupational exposure to styrene has been shown to be associated with an increased probability of developing hearing loss. However, the sites of lesions in the auditory system in humans remain unknown. The aim of this study was to investigate the possible adverse effects of styrene exposure on the cochlea of human subjects. DESIGN: The hearing function of 98 styrene-exposed male workers from the glass fibre-reinforced plastics industry (mean concentration of 55 mg/m3) was evaluated bilaterally using pure-tone audiometry (1000-16000 Hz), distortion product otoacoustic emissions (DPOAEs), and auditory brainstem response (ABR). The results were compared to a group of 111 male workers exposed to noise (above 85 dBA) and 70 male white-collar workers exposed to neither noise nor solvents. Age and noise exposure levels were accounted for as confounding variables in all statistical models. RESULTS: Styrene exposure was significantly associated with poorer pure-tone thresholds (1-8 kHz), lower DPOAE amplitudes (5-6 kHz), and shorter wave V latencies in both ears compared to control-group subjects. Similar results were found among noise-exposed subjects. A further analysis with wave V latency showed that styrene-exposed subjects showed significantly shorter latencies than expected according to normative data. These results suggest that occupational exposure to styrene at moderate concentrations is associated with cochlear dysfunction, at least at high frequencies. DPOAEs may be considered a valuable diagnostic tool in hearing conservation programs in workers exposed to styrene.


Assuntos
Cóclea/fisiopatologia , Perda Auditiva , Exposição Ocupacional/efeitos adversos , Emissões Otoacústicas Espontâneas , Estireno/toxicidade , Adulto , Limiar Auditivo , Perda Auditiva/diagnóstico , Perda Auditiva/fisiopatologia , Perda Auditiva/prevenção & controle , Humanos , Masculino , Pessoa de Meia-Idade , Ruído/efeitos adversos , Adulto Jovem
9.
Pediatrics ; 145(2)2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31915192

RESUMO

OBJECTIVE: To assess the association between gentamicin exposure in the neonatal period and hearing in school age. METHODS: This study included children exposed to a high-dose (6 mg/kg) gentamicin regimen as neonates (2004-2012), invited for follow-up at school age, and a healthy age-matched control group. We assessed hearing with pure tone audiometry including the extended high-frequency (EHF) range. Outcomes were average hearing thresholds in the midfrequencies (0.5-4 kHz) and the EHFs (9-16 kHz). The measures of gentamicin exposure were cumulative dose and highest trough plasma concentration. We used linear regression models to assess the impact of gentamicin exposure, and other peri- and postnatal morbidities, on hearing thresholds. RESULTS: A total of 219 gentamicin-exposed and 33 healthy-control children were included in the audiological analysis. In the gentamicin cohort, 39 (17%) had a birth weight <1500 g. Median cumulative doses and trough plasma concentrations were 30 (interquartile range 24-42) mg/kg and 1.0 (interquartile range 0.7-1.2) mg/L, respectively. Median hearing thresholds for the midfrequencies and the EHFs were 2.5 (0 to 6.3) dB hearing level and -1.7 (-5.0 to 5.0) dB hearing level, both of which were within the normal range. In an adjusted analysis, increasing hearing thresholds were associated with lower birth weight and postnatal middle-ear disease but not level of gentamicin exposure. After adjusting for birth weight, there was no difference in hearing threshold between the gentamicin-exposed cohort and healthy controls. CONCLUSIONS: Exposure to a high-dose gentamicin regimen in the neonatal period was not associated with an increase in hearing thresholds in schoolchildren being able to complete audiometry.


Assuntos
Antibacterianos/administração & dosagem , Limiar Auditivo/efeitos dos fármacos , Gentamicinas/administração & dosagem , Audição/efeitos dos fármacos , Adolescente , Antibacterianos/efeitos adversos , Antibacterianos/sangue , Audiometria de Tons Puros , Limiar Auditivo/fisiologia , Estudos de Casos e Controles , Criança , Potenciais Evocados Auditivos/fisiologia , Feminino , Gentamicinas/efeitos adversos , Gentamicinas/sangue , Audição/fisiologia , Humanos , Recém-Nascido de Baixo Peso/fisiologia , Recém-Nascido , Modelos Lineares , Masculino , Noruega , Tamanho da Amostra
10.
Nat Commun ; 11(1): 324, 2020 01 16.
Artigo em Inglês | MEDLINE | ID: mdl-31949136

RESUMO

Neural adaptation enables sensory information to be represented optimally in the brain despite large fluctuations over time in the statistics of the environment. Auditory contrast gain control represents an important example, which is thought to arise primarily from cortical processing. Here we show that neurons in the auditory thalamus and midbrain of mice show robust contrast gain control, and that this is implemented independently of cortical activity. Although neurons at each level exhibit contrast gain control to similar degrees, adaptation time constants become longer at later stages of the processing hierarchy, resulting in progressively more stable representations. We also show that auditory discrimination thresholds in human listeners compensate for changes in contrast, and that the strength of this perceptual adaptation can be predicted from physiological measurements. Contrast adaptation is therefore a robust property of both the subcortical and cortical auditory system and accounts for the short-term adaptability of perceptual judgments.


Assuntos
Córtex Auditivo/fisiologia , Vias Auditivas/fisiologia , Percepção Auditiva/fisiologia , Mesencéfalo/fisiologia , Neurônios/fisiologia , Tálamo/fisiologia , Adaptação Fisiológica/fisiologia , Animais , Limiar Auditivo/fisiologia , Discriminação Psicológica , Eletrofisiologia , Feminino , Humanos , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Modelos Animais , Modelos Neurológicos , Ruído , Optogenética , Espectrografia do Som
11.
HNO ; 68(Suppl 1): 43-49, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31915885

RESUMO

OBJECTIVE: To develop a new, German, age-appropriate speech audiometry test for children, by using 26 nouns that are most likely part of the lexicon of 2-year-olds. The test is a picture-pointing task with a four-option non-forced choice method. MATERIALS AND METHODS: In total, 179 children aged 2;11 to 6;9 y were included for standardizing and validating the speech test. Of these, 51 had a hearing impairment in both ears ranging up to 90 dB hearing level (HL). The normal-hearing collective was divided into three groups according to age. For each group, the speech reception threshold (SRT) and the slope of the psychometric function of intelligibility were determined. For validation, the test-retest reliability was measured in 85 ears, and the correlation between the pure tone average (PTA) at 0.5, 1, 2, and 4 kHz and the SRT was measured in 86 ears. RESULTS: The sound spectrum of the 26 items was in good accordance with the international long-term speech spectrum, and the relative frequency of phonemes matched the distribution of the 50 more frequent German phonemes. The SRTs ranged from 24.6 ± 0.6 dB sound pressure level (SPL) for the oldest group (> 5.5 y) to 29.3 ± 1.3 dB SPL for the youngest group (< 4.25 y). The slopes of the psychometric function ranged from 4.3 ± 0.5%/dB for the oldest group to 2.6 ± 0.4%/dB for the youngest. The test and retest showed good correlation (r  = 0.89, p < 0.0001) as did the PTA and SRT (r = 0.84, p < 0.0001). CONCLUSION: The newly developed Mainz speech-test effectively measures age-related speech perception from the age of three years.


Assuntos
Percepção da Fala , Teste do Limiar de Recepção da Fala , Fala , Audiometria da Fala , Limiar Auditivo , Criança , Pré-Escolar , Humanos , Reprodutibilidade dos Testes
12.
HNO ; 68(4): 272-277, 2020 Apr.
Artigo em Alemão | MEDLINE | ID: mdl-31915883

RESUMO

BACKGROUND: Hearing loss is frequently induced by occupational noise exposure and leads to rising hearing thresholds as well as reduced otoacoustic emissions (OAE), mostly caused by metabolic hair cell decompensation. OBJECTIVE: Primary endpoint is the increase in average pure tone thresholds after noise exposure, secondary endpoints are loss of distortion product and click-evoked OAE as well as reduction of their contralateral suppression. PARTICIPANTS AND METHODS: The present study design describes the verification of the anti-oxidant and neuroprotective properties of EGb 761® by evaluation of cochlear protection from noise impact as well as its safety and tolerance in 202 healthy male participants distributed equally to verum and placebo groups in a double-blind manner. Participants were assessed, medicated, exposed to noise, and then examined at timepoints up to 10 min and 4 weeks thereafter. CONCLUSION: This summary of the verification study protocol highlights the complexity of diligent and precise planning according to the European Medicines Agency criteria for controlled trials (EudraCT). Key points are the intervention rationale, definitions of in- and exclusion criteria, estimation of subject numbers, and examination method setting in terms of optimum endpoint description.


Assuntos
Perda Auditiva Provocada por Ruído , Extratos Vegetais , Audiometria de Tons Puros , Limiar Auditivo , Cóclea , Método Duplo-Cego , Perda Auditiva Provocada por Ruído/terapia , Humanos , Masculino , Emissões Otoacústicas Espontâneas , Extratos Vegetais/uso terapêutico , Estudos Prospectivos
13.
Otolaryngol Head Neck Surg ; 162(1): 114-120, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31593522

RESUMO

OBJECTIVE: To describe the progression of sensorineural hearing loss (SNHL) in the better- and poorer-hearing ears in children with asymptomatic congenital cytomegalovirus (CMV) infection with isolated SNHL. STUDY DESIGN: Longitudinal prospective cohort study. SETTING: Tertiary medical center. SUBJECTS AND METHODS: We analyzed hearing thresholds of the better- and poorer-hearing ears of 16 CMV-infected patients with isolated congenital/early-onset or delayed-onset SNHL identified through hospital-based CMV screening of >30,000 newborns from 1982 to 1992. RESULTS: By 12 months of age, 4 of 7 patients with congenital/early-onset SNHL developed worsening thresholds in the poorer-hearing ear, and 1 had an improvement in the better-hearing ear. By 18 years of age, all 7 patients had worsening thresholds in the poorer-hearing ear and 3 patients had worsening thresholds in the better-hearing ear. Hearing loss first worsened at a mean age of 2 and 6 years in the poorer- and better-hearing ears, respectively. Nine patients were diagnosed with delayed-onset SNHL (mean age of 9 years vs 12 years for the poorer- and better-hearing ears), 6 of whom had worsening thresholds in the poorer-hearing ear and 1 in both ears. CONCLUSION: In most children with congenital CMV infection and isolated SNHL, the poorer-hearing ear worsened earlier and more precipitously than the better-hearing ear. This study suggests that monitoring individual hearing thresholds in both ears is important for appropriate interventions and future evaluation of efficacy of antiviral treatment.


Assuntos
Doenças Assintomáticas , Infecções por Citomegalovirus/congênito , Progressão da Doença , Perda Auditiva Neurossensorial/epidemiologia , Perda Auditiva Neurossensorial/etiologia , Fatores Etários , Idade de Início , Limiar Auditivo , Criança , Pré-Escolar , Estudos de Coortes , Feminino , Seguimentos , Perda Auditiva Neurossensorial/fisiopatologia , Testes Auditivos , Humanos , Lactente , Recém-Nascido , Estudos Longitudinais , Masculino , Monitorização Fisiológica/métodos , Triagem Neonatal/métodos , Estudos Prospectivos , Medição de Risco , Índice de Gravidade de Doença , Fatores de Tempo , Estados Unidos
14.
Int J Pediatr Otorhinolaryngol ; 128: 109698, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31606682

RESUMO

OBJECTIVES: Slight/mild hearing loss is detrimental to communication and academic achievements. This study aimed to describe the prevalence of hearing loss, and to investigate the factors related to noise-induced hearing loss among South Korean adolescent. METHODS: As a population-based retrospective study, 1845 South Korean adolescents aged from 12 to 19 years were analyzed using the data from Korea National Health and Nutrition Examination Survey V (KNHANES V, 2010-2012). The prevalence of hearing loss according to the side, severity, and frequency was calculated. For assessing the noise-induced hearing loss in adolescent, the prevalence of hearing loss only in high-frequency (onlyHFHL, defined as 1) thresholds at 0.5 and 1 kHz of ≤15 dB HL, and 2) maximal thresholds at 3, 4, or 6 kHz ≥ 15 dB HL higher than the highest threshold for 0.5 and 1 kHz) was analyzed. Moreover, the relevance of onlyHFHL in context of sociodemographic factors and noise exposure history was evaluated. RESULTS: The prevalence of unilateral and bilateral hearing loss based on the average of six frequencies (0.5, 1, 2, 3, 4, and 6 kHz) in South Korean adolescents were 8.56% and 1.03%, respectively, and most cases were hearing loss with slight/mild degree. The prevalence of unilateral and bilateral onlyHFHL were 32.74% and 5.53%, respectively. Factors found to be associated with onlyHFHL were sex (female) and household income (high). CONCLUSIONS: According to this population-based study, the prevalence of slight/mild hearing loss and onlyHFHL in the South Korean adolescents were considerably high. With knowledge of the factors related with onlyHFHL, paying more attention to slight/mild hearing loss will be helpful in preventing hearing loss in adolescents.


Assuntos
Perda Auditiva Bilateral/epidemiologia , Perda Auditiva Provocada por Ruído/epidemiologia , Adolescente , Limiar Auditivo , Criança , Estudos Transversais , Feminino , Perda Auditiva Bilateral/fisiopatologia , Perda Auditiva Provocada por Ruído/fisiopatologia , Humanos , Renda , Masculino , Inquéritos Nutricionais , Prevalência , República da Coreia/epidemiologia , Estudos Retrospectivos , Fatores Sexuais , Adulto Jovem
15.
Braz J Otorhinolaryngol ; 86(2): 149-156, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-30558985

RESUMO

INTRODUCTION: Hearing acuity, central auditory processing and cognition contribute to the speech recognition difficulty experienced by older adults. Therefore, quantifying the contribution of these factors on speech recognition problem is important in order to formulate a holistic and effective rehabilitation. OBJECTIVE: To examine the relative contributions of auditory functioning and cognition status to speech recognition in quiet and in noise. METHODS: We measured speech recognition in quiet and in composite noise using the Malay Hearing in noise test on 72 native Malay speakers (60-82 years) older adults with normal to mild hearing loss. Auditory function included pure tone audiogram, gaps-in-noise, and dichotic digit tests. Cognitive function was assessed using the Malay Montreal cognitive assessment. RESULTS: Linear regression analyses using backward elimination technique revealed that had the better ear four frequency average (0.5-4kHz) (4FA), high frequency average and Malay Montreal cognitive assessment attributed to speech perception in quiet (total r2=0.499). On the other hand, high frequency average, Malay Montreal cognitive assessment and dichotic digit tests contributed significantly to speech recognition in noise (total r2=0.307). Whereas the better ear high frequency average primarily measured the speech recognition in quiet, the speech recognition in noise was mainly measured by cognitive function. CONCLUSIONS: These findings highlight the fact that besides hearing sensitivity, cognition plays an important role in speech recognition ability among older adults, especially in noisy environments. Therefore, in addition to hearing aids, rehabilitation, which trains cognition, may have a role in improving speech recognition in noise ability of older adults.


Assuntos
Limiar Auditivo/fisiologia , Cognição/fisiologia , Ruído , Presbiacusia/fisiopatologia , Percepção da Fala/fisiologia , Estimulação Acústica/métodos , Idoso , Audiometria de Tons Puros , Feminino , Testes Auditivos , Humanos , Masculino , Pessoa de Meia-Idade , Presbiacusia/diagnóstico , Teste do Limiar de Recepção da Fala
16.
Braz J Otorhinolaryngol ; 86(1): 3-13, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-30224263

RESUMO

INTRODUCTION: Patient-reported outcome measures, inventory and or questionnaire, allow patients to present their perspective of the impact of their individual condition on a day-to-day basis, independent of the analysis of test results by the expert clinician. Outcome measures are recommended when there is evidence showing their reliability, validity and sensitivity. There are standardized patient-reported outcome measures for hearing in English language; however, other languages lack these instruments. OBJECTIVE: Adapt the Amsterdam inventory for auditory disability and handicap to Brazilian Portuguese and analyze its validation measures. METHODS: We conducted two studies. In Study 1, we translated and adapted the Amsterdam inventory for auditory disability and handicap to Brazilian Portuguese according to good practice guidelines; this included the pre-test stage. In Study 2, we administered the Portuguese version to adults with and without hearing loss (n=31 and 18, respectively) and analyzed the measures of instrument validation, reliability, and reproducibility. Moreover, we calculated the correlation between pure tone thresholds and scores on the questionnaire. RESULTS: The results obtained in Study 1 demonstrated the feasibility of the translation process and the instrument's cultural adaptation, as well as its applicability, resulting in the Portuguese version of the Amsterdam inventory for auditory disability and handicap. In Study 2, the results revealed construct values for the questions and domains, as well as for the total reliable score. The intra-interviewer test-retest condition showed excellent reproducibility (ICC=0.97). Finally, there was a strong positive correlation (r=0.83) between the mean pure tone threshold and the hearing difficulties values, as measured by the instrument's scores. CONCLUSION: The English version of the Amsterdam inventory for auditory disability and handicap could be translated and adapted to Brazilian Portuguese. An analyses of the validation process yielded reliable, consistent, and stable results.


Assuntos
Comparação Transcultural , Avaliação da Deficiência , Perda Auditiva/diagnóstico , Pessoas com Deficiência Auditiva , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Percepção Auditiva , Limiar Auditivo , Brasil , Estudos Transversais , Feminino , Humanos , Idioma , Masculino , Pessoa de Meia-Idade , Psicometria , Reprodutibilidade dos Testes , Índice de Gravidade de Doença , Inquéritos e Questionários/normas , Tradução , Adulto Jovem
17.
Am J Otolaryngol ; 41(1): 102328, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31732304

RESUMO

OBJECTIVE: This study aimed to investigate the healing effect of metformin on noise induced hearing loss (NIHL) by measuring audiological, biochemical and histological parameters. MATERIALS AND METHODS: 32 rats were divided into four groups (Group 1: Noise, Group 2: Noise + Metformin, Grup 3: Metformin, Grup 4: Control). Broadband noise was applied to Group 1 and Group 2 after basal measurements. Measuring audiological (distortion product otoacoustic emission (DPOAE) and Auditory Brainstem Response (ABR)), biochemical (total antioxidant status (TAS), total oxidant status (TOS), oxidative status index (OSI), DNA damage, IL-1 beta, IL-6, TNF alfa, HSF-1 and COX-2) and histological parameters. RESULTS: Group 2 had significant decreases in ABR thresholds on day 7 and day 14 compared to day 1. DPOAE values of Group 2 on the 7th and 14th days were significantly higher than the post-noise levels. DNA damage, TOS and OSI values of Group 1 were significantly higher than the other groups. The Cox-2 value of Group 1 was higher than all other groups. The HSF-1 value of Group 2 was significantly higher than that of Group 1. In terms of IL-1 Beta, IL-6 and TNF-alpha values, there was no significant difference between groups 2, 3 and 4 and these values were significantly lower than group 1. In histopathological results of our study, no significant difference was found between the groups being exposed to noise and the control group. CONCLUSION: This study showed that early period of Metformin treatment has therapeutic effect on NIHL.


Assuntos
Potenciais Evocados Auditivos do Tronco Encefálico/efeitos dos fármacos , Perda Auditiva Provocada por Ruído/tratamento farmacológico , Metformina/farmacologia , Emissões Otoacústicas Espontâneas/efeitos dos fármacos , Animais , Limiar Auditivo , Biomarcadores/metabolismo , Modelos Animais de Doenças , Feminino , Interleucina-1beta/metabolismo , Interleucina-6/metabolismo , Ratos , Ratos Sprague-Dawley , Fator de Necrose Tumoral alfa/metabolismo
18.
Otolaryngol Clin North Am ; 53(1): 87-102, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31677740

RESUMO

Cochlear implant is the first approved cranial nerve stimulator that works by directly stimulating the cochlear nerve. The medical and societal impact of this revolutionary device cannot be understated. This article reviews the evolving indications for cochlear implant, patient assessment, surgical approach, and outcomes for pediatric and adult cochlear implant that demonstrate its impact. Future concepts in cochlear implant are introduced briefly. This article covers a breadth of information; however, it is not intended be entirely comprehensive. Rather, it should serve as a foundation for understanding cochlear implant.


Assuntos
Implante Coclear/métodos , Implantes Cocleares , Perda Auditiva Neurossensorial/terapia , Adulto , Limiar Auditivo , Criança , Cóclea/patologia , Cóclea/cirurgia , Nervo Coclear/fisiologia , Humanos
19.
Aerosp Med Hum Perform ; 91(1): 32-36, 2020 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-31852571

RESUMO

BACKGROUND: The aim of this study was pure tone audiometry (PTA) evaluation in normal individuals exposed to hypobaric hypoxia, taking into account the influence of air rarefaction on sound transmission via a standard earphone.METHODS: The study was conducted in a hypobaric chamber using a standard audiometer and a TDH-39P earphone whose performance at altitudes was analyzed in a previous research. Eight male volunteers underwent PTA testing at ground level and at 15,000 ft under normoxia (via an oxygen mask) and after 20 min of hypoxia. Auditory threshold at 500, 1000, 2000, and 4000 Hz was recorded from the right ear while monitoring arterial oxygen saturation (Sao2). The PTA data obtained at high altitude were corrected according to a specific recalibration table.RESULTS: During hypoxia, a significant threshold shift was observed only at 4000 Hz, with respect to ground level recording, for the sole not-corrected data. At the same frequency a significant threshold shift was also observed between the ground level recording and normoxia at 15,000 ft, confirming the presence of a hypobaric effect not related to hypoxia. After the recalibration procedure, this hearing impairment was not significant. No correlation with Sao2 levels was observed.DISCUSSION: The mild and not significant presence of high altitude-induced PTA derangements in healthy normal individuals was documented, although a stimulus recalibration was needed for a correct interpretation of our data.Lucertini M, Lancia S, Sanjust F, Guadagno AG, Lucertini L, Sisto R. Lack of significant audiometric changes under hypobaric hypoxia at 15,000 ft. Aerosp Med Hum Perform. 2020; 91(1):32-36.


Assuntos
Medicina Aeroespacial , Altitude , Limiar Auditivo/fisiologia , Hipóxia/etiologia , Hipóxia/fisiopatologia , Adulto , Aeronaves , Audiometria de Tons Puros , Humanos , Masculino , Pessoa de Meia-Idade
20.
Am J Audiol ; 28(4): 1006-1014, 2019 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-31825642

RESUMO

Purpose The purpose of this study was to investigate associations between performance on a clinical speech-in-noise measure with a comprehensive neurocognitive battery of tests. Method A group of older adults (N = 250, M age = 77 years, age range: 67.3-89.1 years) enrolled in the Atherosclerosis Risk in Communities Neurocognitive Study took part in the hearing pilot study (2013) that included testing for audiometric thresholds and speech-in-noise performance (Quick Speech-in-Noise Test; Killion, Niquette, Gudmundsen, Revit, & Banerjee, 2004). This research study analyzed the associations between domain-specific cognitive function and speech-in-noise performance after adjusting for hearing thresholds and other demographic and cardiovascular factors. Results Multivariable-adjusted associations were found between all cognitive domains and speech-in-noise performance in the full sample, but the observed associations varied when participants with varying levels of moderate to moderately severe hearing loss were excluded from the analysis. Conclusions The findings are discussed in terms considering the cognitive status of older adults in relation to their speech-in-noise performance during audiological evaluation and implications for aural rehabilitation.


Assuntos
Cognição , Ruído , Percepção da Fala , Idoso , Idoso de 80 Anos ou mais , Aterosclerose/fisiopatologia , Aterosclerose/psicologia , Limiar Auditivo , Estudos Transversais , Feminino , Perda Auditiva/fisiopatologia , Perda Auditiva/psicologia , Testes Auditivos , Humanos , Masculino , Testes de Estado Mental e Demência , Projetos Piloto
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