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1.
Ann Hematol ; 100(3): 715-723, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33389024

RESUMO

Tumour-infiltrating lymphocytes (TILs) account for a large proportion of tumour microenvironment (TME) in angioimmunoblastic T cell lymphoma (AITL), and at present the significance of TIL in TME of AITL remains unclear. Overall, 50 de novo AITL patients undergoing lymph node flow cytometry from 2014 to 2019 were retrospectively analysed to assess the relationship between TILs and AITL prognosis. We found that high TIL-Bs (≥ 42.4%, p = 0.004) and high CD4:CD8 (≥ 0.85, p = 0.024) were independent favourable prognostic factors for de novo AITL in univariate or multivariate analyses. New TIL-related risk stratification was established based on TIL-Bs and CD4:CD8 factors. Patients in the low-risk group (TIL-Bs ≥ 42.4% and CD4:CD8 ≥ 0.85) had significantly better overall survival than the high-risk (TIL-Bs < 42.4% and CD4:CD8 < 0.85) (p < 0.001) or intermediate-risk group (TIL-Bs ≥ 42.4% and CD4:CD8 < 0.85 or TIL-Bs < 42.4% and CD4:CD8 ≥ 0.85) (p = 0.011). To our knowledge, our cohort is the largest one focusing on the TILs in de novo cases of AITL by analysing lymph node samples using flow cytometry, which is the first time to comprehensively consider humoral immunity and cellular immunity influence on AITL. Our new risk stratification was valuable and useful in evaluating prognosis of AITL and guiding immunotherapy strategies.


Assuntos
Citometria de Fluxo , Linfadenopatia Imunoblástica/patologia , Linfócitos do Interstício Tumoral/patologia , Linfoma de Células T/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , China , Estudos de Coortes , Progressão da Doença , Feminino , Humanos , Linfadenopatia Imunoblástica/diagnóstico , Imunofenotipagem/métodos , Linfoma de Células T/diagnóstico , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Valor Preditivo dos Testes , Prognóstico , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Sensibilidade e Especificidade , Microambiente Tumoral/imunologia
2.
Am J Case Rep ; 22: e927142, 2021 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-33428607

RESUMO

BACKGROUND Subcutaneous panniculitis-like T cell lymphoma and primary cutaneous γdelta T cell lymphoma are rare forms of non-Hodgkin lymphoma presenting as skin nodules or plaques. CASE REPORT Here, we present a case of a 48-year-old man with multiple subcutaneous, tender, erythematous nodules on his right thigh and left arm. Multiple courses of antibiotics were administered with no significant improvement in the patient's lesions. The skin biopsy report showed CD3/CD8 lymphocytic rimming of the adipocytes and the patient was diagnosed with subcutaneous panniculitis-like T cell lymphoma. A subsequent bone marrow biopsy showed hemophagocytic lymphohistiocytosis. The patient underwent treatment with the cyclophosphamide, hydroxydaunorubicin, Oncovin, prednisone, and etoposide chemotherapy regimen and received an autologous peripheral blood stem cell transplant. CONCLUSIONS Nodular skin lesions can result from a variety of noninfectious causes in addition to bacterial and fungal infections. This case highlights the importance of early biopsy of skin lesions that do not respond to standard therapy to establish an accurate diagnosis and start timely treatment to prevent poor outcomes.


Assuntos
Celulite (Flegmão)/diagnóstico , Linfo-Histiocitose Hemofagocítica/complicações , Linfo-Histiocitose Hemofagocítica/diagnóstico , Linfoma de Células T/complicações , Linfoma de Células T/diagnóstico , Paniculite/complicações , Paniculite/diagnóstico , Diagnóstico Diferencial , Humanos , Linfo-Histiocitose Hemofagocítica/terapia , Linfoma de Células T/terapia , Masculino , Pessoa de Meia-Idade , Paniculite/terapia
3.
Beijing Da Xue Xue Bao Yi Xue Ban ; 52(6): 1150-1152, 2020 Dec 18.
Artigo em Chinês | MEDLINE | ID: mdl-33331330

RESUMO

Angioimmunoblastic T-cell lymphoma is a rare T-cell lymphoma. The clinical manifestations are not specific. In addition to the common clinical manifestations of lymphomas such as fever, weight loss, night sweats and lymphadenopathy, it may also have skin rashes, arthritis, multiple serous effusions, eosinophilia and other systemic inflammatory or immune symptoms. The lymphoma cells of angioimmunoblastic T-cell lymphoma originates from follicular helper T cells, and the follicular structure of lymph nodes disappears. In the tumor microenvironment, in addition to tumor cells, there are a large number of over-activated immune cells, such as abnormally activated B cells, which produce a series of systemic inflammation or immune-related symptoms. This disease is rare and difficult to diagnose. This article reports a 36-year-old female. She got fever, joint swelling and pain, skin pigmentation, accompanied by hepatomegaly, splenomegaly, lymphadenopathy, anemia and other multiple-systems manifestations. The clinical manifestations of this patient were similar to autoimmune diseases such as adult onset Still's disease, rheumatoid arthritis, and systemic sclerosis, which made the diagnosis difficult. At the beginning of the disease course, the patient got arthritis and fever. And her white blood cells were significantly increased. Adult onset Still's disease should be considered, but her multiple-systems manifestations could not be explained by adult onset Still's disease. And her arthritis of hands should be distinguished with rheumatoid arthritis. However, the patient's joint swelling could get better within 3-7 days, and there was no synovitis and bone erosion on joint imaging examination. The rheumatoid factor and anti-CCP antibody were negative. The diagnostic evidence for rheumatoid arthritis was insufficient. The patient's skin pigmentation and punctate depigmentation were similar to those of systemic sclerosis. But the patient had no Raynaud's phenomenon, and her sclerosis-related antibody was negative. The diagnostic evidence for systemic sclerosis was also insufficient. After 3 years, she was finally diagnosed with angioimmunoblastic T-cell lymphoma by lymph node biopsy aspiration. This case suggests that the clinical manifestations of angioimmunoblastic T-cell lymphoma are diverse, and some symptoms similar to immune diseases may appear. When the patient's clinical symptoms are atypical and immune diseases cannot explain the patient's condition, and further evidence should be sought to confirm the diagnosis.


Assuntos
Linfadenopatia Imunoblástica , Linfoma de Células T , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Linfadenopatia Imunoblástica/diagnóstico , Linfoma de Células T/complicações , Linfoma de Células T/diagnóstico , Pigmentação da Pele , Tomografia Computadorizada por Raios X , Microambiente Tumoral
4.
Zhonghua Bing Li Xue Za Zhi ; 49(10): 1021-1026, 2020 Oct 08.
Artigo em Chinês | MEDLINE | ID: mdl-32992416

RESUMO

Objective: To investigate the clinicopathological characteristics of the T cell lymphomas with CD20 expression, and to better understand this rare entity. Methods: Two-hundred cases of T-cell lymphoma diagnosed in the Department of Pathology of the Affiliated Hospital of Qingdao University from November 2016 to February 2020 were examined, and 5 cases of CD20-positive T-cell lymphomas were identified and included. Combined with clinical data and review of the literature, the clinicopathological characteristics of the disease were analyzed. Results: The five patients were all male, and had an average age of 56 years (range, 47 to 64 years). There were 2 cases of monomorphic epitheliotropic intestinal T-cell lymphoma, 2 cases of mycosis fungoides (1 case was plaque stage and the other was tumor stage) and 1 case of indolent T-cell lymphoproliferative disorder of the gastrointestinal tract. Immunohistochemistry showed that all 5 cases expressed multiple T cell markers (CD3/CD4/CD5/CD7/CD8) and only one of B cell markers (CD20). Three of the 5 cases were negative for CD20 at the first diagnosis, while CD20 was diffusely positive on the second biopsy from the recurrence or progression of the disease, without expression of CD79a or PAX5. Epstein-Barr encoding region (EBER) in situ hybridization was negative in all 5 cases. T-cell receptor gene analysis showed monoclonal rearrangement of ß or/and δ chains;Ig rearrangements were all polyclonal. None of the five patients were treated with rituximab, and 4 patients survived with disease and 1 patient survived without disease at the end of follow-up. Among them, the patient with mycosis fungoides at the cancerous stage has progressed rapidly and had poor quality of life. Conclusions: CD20-positive T-cell lymphoma is extremely rare. Its prognosis is closely related to the type of T-cell lymphoma, clinical stage and initial therapeutic effect. However, the expression of CD20 indicates the recurrence or progression of the disease, and the prognosis is relatively poor. When CD3 expression is absent in T-cell lymphoma, it is easy to be misdiagnosed as B-cell lymphoma. The combination of multiple immunohistochemical antibodies and molecular detection can improve the accuracy of diagnosis.


Assuntos
Linfoma de Células T/diagnóstico , Linfoma de Células T/tratamento farmacológico , Linfoma de Células T/genética , Micose Fungoide , Neoplasias Cutâneas , Antígenos CD20 , Humanos , Masculino , Pessoa de Meia-Idade , Qualidade de Vida
5.
HNO ; 68(9): 695-697, 2020 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-32728760

RESUMO

A rare finding of primary cutaneous CD4+ small to medium-sized T­cell lymphoma (SMPTCL) in a fifteen-year-old patient is reported. This is a rare tumor entity for which there is currently no standardized treatment recommendation. At the interdisciplinary tumor board, the decision was made to resect the tumor and reconstruct the defect with a nasolabial advancement flap in a two-stage process. Follow-up examinations, currently over 3 years, have shown the patient to be free of recurrences.


Assuntos
Linfoma Cutâneo de Células T , Linfoma de Células T , Neoplasias Cutâneas , Adolescente , Linfócitos T CD4-Positivos , Humanos , Linfoma de Células T/diagnóstico , Linfoma de Células T/cirurgia , Linfoma Cutâneo de Células T/diagnóstico , Linfoma Cutâneo de Células T/cirurgia , Recidiva Local de Neoplasia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/cirurgia
7.
10.
Blood ; 135(13): 1058-1061, 2020 03 26.
Artigo em Inglês | MEDLINE | ID: mdl-32005988
11.
BMJ Case Rep ; 13(1)2020 Jan 19.
Artigo em Inglês | MEDLINE | ID: mdl-31959653

RESUMO

An 18-year-old male patient presented to the emergency department complaining of new onset chest pain, fever and orthopnoea. Initial workup was remarkable for elevated troponin, diffuse ST-segment elevation on ECG and chest X-ray with enlarged cardiac silhouette. Transthoracic echocardiogram (TTE) demonstrates severe biventricular concentric hypertrophy and pericardial effusion. Also, Coxsackie virus A and B titres were positive, concerning for a classic viral pericarditis. However, despite medical management, the patient became dyspnoeic and hypotensive. Impending cardiac tamponade was observed on repeat TTE, and pericardiocentesis was performed, complicated by pulseless electrical activity cardiac arrest, and ultimately patient requiring venoarterial extracorporeal membrane oxygenation support. Emergent endomyocardial biopsy showed no inflammatory process, and a skin biopsy of a small lesion in the right arm showed unexpected diagnosis of Epstein-Barr virus (+) natural killer/T-cell lymphoma. On initiation of chemotherapy, clinical improvement was observed as evidenced by improving ejection fraction, resolution of pericardial effusion and gradual decrease in myocardial hypertrophy.


Assuntos
Tamponamento Cardíaco/etiologia , Insuficiência Cardíaca/etiologia , Linfoma de Células T/diagnóstico , Miocardite/etiologia , Derrame Pericárdico/etiologia , Adolescente , Biópsia , Diagnóstico Diferencial , Ecocardiografia , Humanos , Linfoma de Células T/complicações , Masculino , Pericardiocentese
12.
Virchows Arch ; 476(5): 667-681, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31773249

RESUMO

This paper summarizes two sessions of the workshop during the XIX meeting of the European Association for Haematopathology (EAHP) held in Edinburgh in September 2018 dedicated to lymphomas of the gastrointestinal tract. The first session focused on the clinical and pathological features of primary gastrointestinal T cell and NK-cell lymphoproliferative disorders. The distinction between precursor lesions (RCD type 2) and enteropathy-associated T cell lymphoma were stressed, including the discussion of new diagnostic markers for the identification of aberrant phenotypes. Indolent T cell lymphoproliferative disorders of the gastrointestinal tract cases showed phenotypic heterogeneity with novel molecular alterations in few cases, such as STAT3-JAK2 fusion. In addition, novel clonal markers of disease, such as AXL and JAK3 somatic variants support the neoplastic nature of NK-cell enteropathy. The session on gastrointestinal tract B cell lymphoproliferations was dedicated to B cell lymphoproliferative disorders that arise primarily in the gastrointestinal tract (i.e., duodenal-type follicular lymphoma) or preferentially involve the digestive tract, such as large B cell lymphoma with IRF4 translocation and mantle cell lymphoma (MCL), including diverse molecular subtypes (i.e., CCND3-positive MCL mimicking MALT lymphoma). Challenging cases of high-grade B cell lymphomas with complex genetic profiles demonstrated the usefulness of novel molecular diagnostic methods such as targeted NGS to identify high-risk genetic features with potential clinical impact.


Assuntos
Linfoma de Zona Marginal Tipo Células B/diagnóstico , Linfoma de Células T/diagnóstico , Transtornos Linfoproliferativos/diagnóstico , Trato Gastrointestinal/patologia , Humanos , Linfoma de Zona Marginal Tipo Células B/genética , Linfoma de Zona Marginal Tipo Células B/patologia , Linfoma de Células T/genética , Linfoma de Células T/patologia , Transtornos Linfoproliferativos/genética , Transtornos Linfoproliferativos/patologia , Fusão Oncogênica
13.
Virchows Arch ; 476(5): 633-646, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31758317

RESUMO

Two sessions in the workshop of the 19th meeting of the European Association for Haematopathology termed "challenging extranodal lymphoproliferations" and "extranodal non-site-specific lymphoproliferations", dealt with a series of heterogenous cases. These included lymphoproliferations of all cell lineages, from reactive lesions mimicking lymphomas through indolent lymphoid neoplasia and tumours with unclear biological behaviour to aggressive and transformed lymphomas. The themes addressed included cases with borderline features between hyperplastic and neoplastic lesions, the diagnostic spectrum of IgG4-related disease, T cell lymphoproliferations arising in extranodal sites with presumed indolent behaviour, diverse clinical presentations of intravascular large B cell lymphoma, diagnostic problems encountered with tumours displaying plasmablastic morphology, pitfalls concerning rare entities like adult T cell lymphoma/leukaemia (ATLL) and extranodal natural killer/T cell (NK/T) lymphomas, and unusual clinical presentations of various lymphomas. Altogether, within the frame of these two sessions, 75 cases remarkably differing in their clinical background, genetic features and overall need for a meticulous diagnostic approach were presented and discussed. In this paper, the salient points raised during the discussion of the cases, current diagnostic concepts and recommendations relevant to the diagnosis of these lymphoproliferations are described.


Assuntos
Doença Relacionada a Imunoglobulina G4/diagnóstico , Linfoma de Células B/diagnóstico , Linfoma de Células T/diagnóstico , Transtornos Linfoproliferativos/diagnóstico , Educação , Humanos , Doença Relacionada a Imunoglobulina G4/classificação , Doença Relacionada a Imunoglobulina G4/genética , Doença Relacionada a Imunoglobulina G4/patologia , Linfoma de Células B/classificação , Linfoma de Células B/genética , Linfoma de Células B/patologia , Linfoma de Células T/classificação , Linfoma de Células T/genética , Linfoma de Células T/patologia , Transtornos Linfoproliferativos/classificação , Transtornos Linfoproliferativos/genética , Transtornos Linfoproliferativos/patologia
14.
Pathology ; 52(1): 78-99, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31785821

RESUMO

Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of uncommon malignancies derived from mature T cells and usually characterised by an aggressive clinical course. Their clinical presentation, localisation and pattern of dissemination are highly variable, but the majority of cases present as nodal diseases. The recently revised classification of lymphomas has incorporated many new molecular genetic data derived from gene expression profiling and next generation sequencing studies, which refine the definition and diagnostic criteria of several entities. Nevertheless, the distinction of PTCL from various reactive conditions, and the diagnosis of PTCL subtypes remains notably challenging. Here, an updated summary of the clinicopathological and molecular features of the most common nodal-based PTCLs (angioimmunoblastic T-cell lymphoma and other nodal lymphomas derived from follicular T helper cells, anaplastic large cell lymphomas and peripheral T-cell lymphoma, not otherwise specified) is presented. Practical recommendations in the diagnostic approach to nodal T-cell lymphoproliferations are presented, including indications for the appropriate use and interpretation of ancillary studies. Finally, we discuss commonly encountered diagnostic problems, including pitfalls and mimics in the differential diagnosis with various reactive conditions, and the criteria that allow proper identification of distinct PTCL entities.


Assuntos
Expressão Gênica/fisiologia , Linfoma Anaplásico de Células Grandes/patologia , Linfoma de Células T Periférico/patologia , Linfoma de Células T/patologia , Diagnóstico Diferencial , Perfilação da Expressão Gênica/métodos , Humanos , Linfoma Anaplásico de Células Grandes/diagnóstico , Linfoma de Células T/diagnóstico , Linfoma de Células T Periférico/genética
15.
Arch Pathol Lab Med ; 144(5): 602-611, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-31556696

RESUMO

CONTEXT.­: Angioimmunoblastic T-cell lymphomas originate from T follicular helper cells and express respective markers (BCL6, CD10, CXCL13, ICOS, and PD-1). Although commonly present, bone marrow involvement by angioimmunoblastic T-cell lymphoma can be diagnostically challenging. Additionally, only little is known about the distribution of T follicular helper cells in healthy and reactively changed bone marrows or in samples affected by other lymphomas. OBJECTIVE.­: To establish a diagnostic approach to reliably identify bone marrow infiltration of angioimmunoblastic T-cell lymphoma. DESIGN.­: We analyzed the morphologic infiltration pattern and the expression of T follicular helper-cell markers in 42 matched paired lymph node and bone marrow samples and applied comparative clonality testing. Furthermore, we studied the expression of BCL6 and PD-1 in a control cohort of healthy, reactively changed, and otherwise affected bone marrows. RESULTS.­: We identified 3 different bone marrow infiltration patterns correlating with overall survival (interstitial/micronodular infiltration with or without eosinophilia and diffuse infiltration with eosinophilia). The matched pairs showed a consistent (co)expression of PD-1 and BCL6 with a generally weaker expression in the bone marrow than in the lymph nodes. Comparative clonality testing was helpful in only a minority of cases. Infiltrates of the most important differential diagnoses contained either PD-1- or BCL6-positive tumor-infiltrating cells, but no coexpressing cells. CONCLUSIONS.­: Bone marrow infiltration by angioimmunoblastic T-cell lymphoma displays 3 different patterns that correlate with prognosis. BCL6 and PD-1 can be reliably used to identify lymphoma infiltrates and to help rule out several differential diagnoses. Comparative clonality testing rarely provides additional value and cannot replace morphologic and phenotypic analyses.


Assuntos
Biomarcadores Tumorais/metabolismo , Linfadenopatia Imunoblástica/diagnóstico , Linfoma Folicular/diagnóstico , Linfoma de Células T/diagnóstico , Idoso , Idoso de 80 Anos ou mais , Medula Óssea/patologia , Quimiocina CXCL13/metabolismo , Feminino , Humanos , Linfadenopatia Imunoblástica/metabolismo , Linfadenopatia Imunoblástica/patologia , Linfonodos/patologia , Linfoma Folicular/metabolismo , Linfoma Folicular/patologia , Linfoma de Células T/metabolismo , Linfoma de Células T/patologia , Masculino , Pessoa de Meia-Idade , Neprilisina/metabolismo , Fenótipo , Prognóstico , Receptor de Morte Celular Programada 1/metabolismo , Proteínas Proto-Oncogênicas c-bcl-6/metabolismo , Suíça , Linfócitos T Auxiliares-Indutores/patologia
16.
J Small Anim Pract ; 61(9): 588-592, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30390298

RESUMO

A 7-year-old mixed breed dog was presented with a 2-week history of vomiting, diarrhoea, weakness and loss of appetite. Initial laboratory tests revealed hyponatraemia and hyperkalaemia consistent with hypoadrenocorticism. Basal plasma cortisol and adrenocorticotropic hormone concentrations were not suggestive of primary hypoadrenocorticism but the aldosterone concentration was undetectable. Abdominal ultrasound scan showed a mass within the left kidney and a nodular enlargement of the left adrenal gland. Cytological analysis revealed a large granular lymphoma. The dog died 17 days later. Post mortem histological and immunohistochemical examinations revealed a diffuse large granular T-cell lymphoma involving the mediastinal lymph node, kidneys, pancreas, adrenal and pituitary glands.


Assuntos
Insuficiência Adrenal , Doenças do Cão , Hipoaldosteronismo , Linfoma de Células T , Glândulas Suprarrenais/diagnóstico por imagem , Insuficiência Adrenal/diagnóstico , Insuficiência Adrenal/veterinária , Animais , Doenças do Cão/diagnóstico , Cães , Hipoaldosteronismo/veterinária , Linfoma de Células T/complicações , Linfoma de Células T/diagnóstico , Linfoma de Células T/veterinária , Hipófise
19.
PLoS One ; 14(12): e0226357, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31826004

RESUMO

Lymphoma is the most common hematopoietic tumour in dogs and is remarkably similar to the human disease. Tumour biomarker discovery is providing new tools for diagnostics and predicting therapeutic response and clinical outcome. MicroRNAs are small non-coding RNAs that participate in post-transcriptional gene regulation and their aberrant expression can impact genes involved in cancer. The aim of this study was to characterize microRNA expression in lymph nodes and plasma from dogs with multicentric B or T cell lymphoma compared to healthy control dogs. We further compared expression between lymph nodes and corresponding plasma samples and assessed changes in expression at relapse compared to time of diagnosis. Lastly, we investigated microRNAs for association with clinical outcome in patients treated with CHOP chemotherapy. A customized PCR array was utilized to profile 38 canine target microRNAs. Quantification was performed using real time RT-qPCR and relative expression was determined by the delta-delta Ct method. In lymph nodes, there were 16 microRNAs with significantly altered expression for B cell lymphoma and 9 for T cell lymphoma. In plasma, there were 15 microRNAs altered for B cell lymphoma and 3 for T cell lymphoma. The majority of microRNAs did not have correlated expression between lymph node and plasma and only 8 microRNAs were significantly different between diagnosis and relapse. For B cell lymphoma, 8 microRNAs had differential expression in the non-remission group compared to dogs that completed CHOP in complete remission. Four of these microRNAs were also altered in patients that died prior to one-year. Kaplan-Meier survival curves for high versus low microRNA expression revealed that 10 microRNAs were correlated with progression-free survival and 3 with overall survival. This study highlights microRNAs of interest for canine multicentric lymphoma. Future goals include development of microRNA panels that may be useful as biomarkers with the intent to provide improved outcome prediction to veterinary cancer patients.


Assuntos
Doenças do Cão/diagnóstico , Linfoma de Células B/diagnóstico , Linfoma de Células T/diagnóstico , MicroRNAs/metabolismo , Animais , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Biomarcadores Tumorais/genética , Biomarcadores Tumorais/metabolismo , Ciclofosfamida/uso terapêutico , Doenças do Cão/tratamento farmacológico , Doenças do Cão/genética , Doenças do Cão/mortalidade , Cães , Doxorrubicina/uso terapêutico , Feminino , Regulação Neoplásica da Expressão Gênica , Imunofenotipagem , Estimativa de Kaplan-Meier , Linfonodos/metabolismo , Linfoma de Células B/tratamento farmacológico , Linfoma de Células B/genética , Linfoma de Células B/mortalidade , Linfoma de Células T/tratamento farmacológico , Linfoma de Células T/genética , Linfoma de Células T/mortalidade , Masculino , MicroRNAs/sangue , Recidiva Local de Neoplasia , Prednisona/uso terapêutico , Intervalo Livre de Progressão , Resultado do Tratamento , Vincristina/uso terapêutico
20.
Cutis ; 104(5): 297-300, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31886782

RESUMO

We report a case of a 7-year-old Chinese boy who presented with acute fever, multiple oral ulcers, and skin nodules. A diagnosis of systemic Epstein-Barr virus (EBV)-positive T-cell lymphoma of childhood was established using systemic laboratory examination, imaging studies, bone marrow and skin biopsy with immunohistochemistry, and in situ hybridization for EBV-encoded RNA (EBER) and gene rearrangements. Notable features of this case include the absence of pancytopenia and hemophagocytic syndrome as well as spontaneous resolution without chemotherapy for several months; however, the condition relapsed, and the patient died.


Assuntos
Infecções por Vírus Epstein-Barr/diagnóstico , Linfoma de Células T/diagnóstico , Neoplasias Cutâneas/diagnóstico , Protocolos de Quimioterapia Combinada Antineoplásica , Criança , Diagnóstico Diferencial , Infecções por Vírus Epstein-Barr/complicações , Infecções por Vírus Epstein-Barr/tratamento farmacológico , Evolução Fatal , Febre/etiologia , Humanos , Linfoma de Células T/complicações , Linfoma de Células T/tratamento farmacológico , Masculino , Úlceras Orais/etiologia , Neoplasias Cutâneas/complicações , Neoplasias Cutâneas/tratamento farmacológico
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