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1.
Diagn Pathol ; 17(1): 93, 2022 Dec 13.
Artigo em Inglês | MEDLINE | ID: mdl-36514176

RESUMO

BACKGROUND: Germline TP53 mutations have been frequently reported in patients with Li-Fraumeni syndrome (LFS), resulting in a predisposition to various malignancies. Mutations other than germline TP53 mutations can also cause LFS-associated malignancies, but their details remain unclear. We describe a novel c-myc amplification in a unique liposarcoma in a patient with LFS. CASE PRESENTATION: A female patient with LFS developed breast cancer twice at the age of thirty; both were invasive ductal carcinomas harboring HER2 amplifications. Computed tomography revealed an anterior mediastinal mass, which was surgically resected. Histological analysis revealed three different lesions corresponding to myxoid liposarcoma-, pleomorphic liposarcoma-, and well-differentiated liposarcoma-like lesions. Fluorescence in-situ hybridization (FISH) analysis did not detect MDM2 amplification, Rb1 deletion, break apart signals of EWS, FUS, DDIT3, or c-myc, or c-myc-IGH fusion signals, but it did detect more c-myc signals. Further FISH analysis and comprehensive genomic profiling revealed c-myc amplification. We considered two differential diagnoses, dedifferentiated liposarcoma lacking MDM2 amplification and myxoid pleomorphic liposarcoma (MPLPS), and determined that this case is most likely MPLPS. However, definite diagnosis could not be made because a clear-cut differentiation of the case from liposarcomas was not possible. CONCLUSIONS: A previous study demonstrated that c-myc amplification could not be detected in various liposarcomas, but the present unique liposarcoma showed c-myc amplification, so the c-myc amplification may indicate that the present liposarcoma is an LFS-related tumor. The present case further clarifies the pathological features of MPLPS and LFS-related liposarcomas by broadening their histopathological and genetic diversities.


Assuntos
Síndrome de Li-Fraumeni , Lipoma , Lipossarcoma Mixoide , Lipossarcoma , Feminino , Humanos , Adulto , Síndrome de Li-Fraumeni/complicações , Síndrome de Li-Fraumeni/diagnóstico , Síndrome de Li-Fraumeni/genética , Lipossarcoma/diagnóstico , Lipossarcoma/genética , Lipossarcoma/patologia , Lipossarcoma Mixoide/diagnóstico , Lipossarcoma Mixoide/genética , Lipossarcoma Mixoide/patologia , Lipoma/patologia , Hibridização in Situ Fluorescente , Genômica , Proteínas Proto-Oncogênicas c-mdm2/genética , Proteínas Proto-Oncogênicas c-mdm2/análise
2.
Biomed Res Int ; 2022: 1580410, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36531655

RESUMO

Background: Insulinoma-associated protein 1 (INSM1) has been identified as a nuclear marker of neuroendocrine tumors. Although INSM1 appears to be a subtle and specific biomarker for neuroendocrine tumor, its expression and clinicopathological significance in mesenchymal tumors remain unclear. Methods: We analyzed INSM1 mRNA level in GEO database and conducted immunohistological staining to detect the expression of INSM1 on 576 mesenchymal tumors from pathology department of Tongji Hospital. Results: At transcription level, INSM1 expression in AITL (angioimmunoblastic T-cell lymphoma) was higher than their adjacent normal tissues as well as Hodgkin's lymphoma. Moreover, INSM1 expression in well-differentiated liposarcoma (WDLPS) was significantly higher than normal fat (P = 0.014) and dedifferentiated liposarcoma (DDLPS) (P = 0.0248). At protein level, the positive rate of INSM1 in AITL was 18/48 (47.4%), while in DDLPS was 9/20 (45%). INSM1 expression in AITL was significantly higher than Hodgkin's lymphoma (P = 0.008). And INSM1 expression in WDLPS was significantly lower than DDLPS (P = 0.015). Conclusion: The combination of GEO data and immunohistochemistry data indicated that the expression level of INSM1 was higher in AITL compared with normal control, suggesting that INSM1 may be involved in pathogenesis of AITL. The abnormal expression of INSM1 was found in WDLPS, and the positive rate of INSM1 was higher in DDLPS than in WDLPS. INSM1 may be involved in the regulation of liposarcoma development. There were significant differences in the expression of INSM1 between AITL and Hodgkin's lymphoma and WDLPS and DDLPS. These findings may assist in the differential diagnosis of these tumors when common markers are difficult to identify, enriching the diagnostic index system of mesenchymal tumors.


Assuntos
Doença de Hodgkin , Lipoma , Lipossarcoma , Tumores Neuroendócrinos , Humanos , Doença de Hodgkin/diagnóstico , Lipossarcoma/diagnóstico , Imuno-Histoquímica , Lipoma/patologia , Diagnóstico Diferencial , Tumores Neuroendócrinos/diagnóstico , Biomarcadores Tumorais/genética , Biomarcadores Tumorais/metabolismo , Proteínas Repressoras/genética
3.
Harefuah ; 161(11): 668-669, 2022 Nov.
Artigo em Hebraico | MEDLINE | ID: mdl-36578236

RESUMO

INTRODUCTION: Lipoma of the nerve is an uncommon tumor, and usually has the highest incidence in the upper limb, especially in the median nerve. When the lesion is large it can cause peripheral neuropathy such as carpal tunnel syndrome. Therefore, a physical examination is paramount for correct surgery and patient preparation. In this article we present a case that was mainly diagnosed by a complete physical examination, which led to the selection of appropriate surgery for the patient.


Assuntos
Síndrome do Túnel Carpal , Lipoma , Humanos , Síndrome do Túnel Carpal/diagnóstico , Síndrome do Túnel Carpal/etiologia , Síndrome do Túnel Carpal/patologia , Nervo Mediano/patologia , Nervo Mediano/cirurgia , Lipoma/complicações , Lipoma/diagnóstico , Lipoma/patologia , Extremidade Superior/patologia , Exame Físico/efeitos adversos
4.
Pan Afr Med J ; 42: 292, 2022.
Artigo em Francês | MEDLINE | ID: mdl-36415335

RESUMO

Lipoma is a benign soft tissue tumour. It is a benign proliferation of mature adipocytes. It is described as giant when its weight exceeds 1 kg or its diameter exceeds 5 cm. Functional and aesthetic impairment may be a major reason for surgical excision. It can be located everywhere, but it mainly occurs in the posterior segment of the chest. We here report a case of giant lipoma of the left posterior-superior segment of the chest.


Assuntos
Lipoma , Neoplasias de Tecidos Moles , Humanos , Hipestesia , Lipoma/diagnóstico , Lipoma/cirurgia , Lipoma/patologia
5.
Pan Afr Med J ; 42: 300, 2022.
Artigo em Francês | MEDLINE | ID: mdl-36415341

RESUMO

Subcutaneous lipomas are very common tumors preferentially occurring in the neck and trunk. Although rare and unusual, they can occur in other parts of the body. Then they should be suspected in patients with subcutaneous swellings. We here report 3 cases of lipomas occurring in rare sites, detailing diagnosis and treatment. They occurred in the interdigital web space of the hand, toe and lateral canthus of the eye.


Assuntos
Lipoma , Humanos , Lipoma/diagnóstico , Lipoma/patologia , Mãos/patologia
6.
Neurol India ; 70(Supplement): S302-S305, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36412385

RESUMO

Among all intramedullary spinal cord lesions, intramedullary spinal cord lipomas account less than 1%. Non-dysraphic intramedullary lipoma is very rare. It is most commonly seen in cervicodorsal region followed by cervico bulbar, lumbar and sometimes multiple. Here we present a 17-year-old female who underwent MRI due to upper dorsal pain followed by progressive bilateral lower limb weakness which showed intramedullary lesion extending from T1-T9, involving eight vertebral segments with distal syrinx and features suggestive of lipoma. Patient underwent surgical decompression of lipoma. Patient had an uneventful post-operative period. Diagnosis confirmed by histopathology.


Assuntos
Lipoma , Neoplasias da Medula Espinal , Vértebras Torácicas , Adolescente , Feminino , Humanos , Lipoma/complicações , Lipoma/diagnóstico por imagem , Lipoma/patologia , Lipoma/cirurgia , Neoplasias da Medula Espinal/complicações , Neoplasias da Medula Espinal/diagnóstico por imagem , Neoplasias da Medula Espinal/patologia , Neoplasias da Medula Espinal/cirurgia , Imageamento por Ressonância Magnética , Dor nas Costas/etiologia , Paraplegia/etiologia
7.
Am J Case Rep ; 23: e937969, 2022 Nov 10.
Artigo em Inglês | MEDLINE | ID: mdl-36352757

RESUMO

BACKGROUND Nevus lipomatosus superficialis (NLS) is a rare benign hamartomatous lesion characterized by adipocyte infiltration into the dermal layer of the skin. Clinically, there are 2 types of NLS lesions: the classical type and the solitary type. The solitary type of NLS is significantly more common in women, typically presents after age 30 years, and occurs most often in the inner thighs. This lesion is often mistaken for similar cutaneous lesions, including but not limited to acrochordons, fibrolipoma, neurofibromatosis, and lymphangioma. There is limited information in the literature on unique presentations of this rare lesion. CASE REPORT We present a case of a 26-year-old woman worried about a pedunculated papule in a fluid-filled capsule on her right inner thigh. She reported that the lesion doubled in size within 48 h prior to presentation. The lesion was biopsied in the clinic and pathology showed lobules of adipose cells in the dermis surrounded by collagen fibers and vascularity consistent with a diagnosis of inflamed NLS. Upon follow-up 2 weeks later, there were no signs of recurrence. CONCLUSIONS It was hypothesized that the unique presentation of a fluid-filled capsule surrounding a nevus lipomatosus superficialis occurred acutely following torsion of the pedunculated lesion. In addition to the patient's history of frictional rub between the thighs, histologic signs of lymphocytic infiltration in the dermis and edematous stroma supported the claim of torsional origins. The unique presentation of NLS in a fluid-filled capsule is not often discussed in the literature, and we hope this report will aid providers in identifying such lesions in the clinic.


Assuntos
Hamartoma , Lipoma , Lipomatose , Nevo , Neoplasias Cutâneas , Feminino , Humanos , Adulto , Lipomatose/diagnóstico , Nevo/diagnóstico , Nevo/patologia , Neoplasias Cutâneas/patologia , Lipoma/patologia , Inflamação
8.
Medicine (Baltimore) ; 101(42): e31303, 2022 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-36281105

RESUMO

RATIONALE: Lipomas are tumors composed of mature adipocytes, originating from the mesoderm, and are the most common soft tissue tumor. According to the World Health Organization classification of human soft tissue and bone tumors, there are 14 types of benign tumors, including mature adipose tissue. Osteolipoma is known as the rarest subtype of lipoma. PATIENT CONCERNS: A 63-year-old female presented to our hospital for the evaluation and treatment of a palpable mass with pain in the right knee. DIAGNOSIS: The diagnosis was confirmed as lipoma with osteocartilaginous metaplasia. INTERVENTIONS: Surgical removal of the tumor was performed. OUTCOMES: The main symptoms improved immediately after the surgery and recovered without any complications or recurrence until 2 years after surgery. LESSONS: Lipoma with osteochondral degeneration is a rare variant of lipoma and it is important to differentiate it from other malignant tumors. Pathological confirmation should be performed after marginal resection of the mass.


Assuntos
Lipoma , Feminino , Humanos , Pessoa de Meia-Idade , Lipoma/diagnóstico , Lipoma/cirurgia , Lipoma/patologia , Tecido Adiposo/patologia , Articulação do Joelho/cirurgia , Articulação do Joelho/patologia , Metaplasia/cirurgia , Joelho/patologia
9.
Diagn Pathol ; 17(1): 77, 2022 Oct 12.
Artigo em Inglês | MEDLINE | ID: mdl-36224593

RESUMO

BACKGROUND: Thymofibrolipoma has been described as a variant of thymolipoma. To date, 3 cases have been reported, and the lesion have been described to consist of extensive areas of collagenous tissue interspersed with islands of mature adipose tissue and strands of thymic tissue. CASE PRESENTATION: A 43-year-old woman had an anterior mediastinal tumor. Macroscopically, the cut surface of the tumor was composed of a yellowish lipomatous component and a uniform whitish fibrous component with elastic stiffness. Microscopically, the tumor was composed of collagenous fibrous tissue with sparse spindle cells, mature adipocytes and strands or islands of thymic tissue. The spindle cells in the fibrous tissue had monoallelic deletion of the 13q14 region and corresponding loss of RB1 and FOXO1A protein expression. CONCLUSIONS: This case report may strengthen the hypothesis that thymofibrolipoma is a neoplastic lesion and a variant of thymolipoma and that thymofibrolipoma and lipofibroadenoma are different names for the same lesion. The name "lipofibroadenoma" was given to the lesion because of its histological resemblance to fibroadenoma of the mammary gland. However, this name does not reflect the pathogenesis of this lesion, and the name "thymofibrolipoma" would be preferable. It will be necessary to discuss whether lipofibroadenoma should be listed as an independent entity in the WHO classification.


Assuntos
Lipoma , Neoplasias do Mediastino , Neoplasias do Timo , Adulto , Feminino , Humanos , Lipoma/genética , Lipoma/patologia , Neoplasias do Mediastino/patologia , Mediastino/patologia , Neoplasias do Timo/diagnóstico , Neoplasias do Timo/genética , Neoplasias do Timo/patologia
10.
Am J Case Rep ; 23: e937575, 2022 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-36215216

RESUMO

BACKGROUND Liposarcoma of the vulva is an exceptionally rare malignant tumor. Clinically, vulvar liposarcoma often mimics benign lesions, thus misdiagnosis is common. Herein, we present a case of myxoid liposarcoma of the vulva. To the best of our knowledge, this is the first case report of vulvar liposarcoma from Indonesia. CASE REPORT We present a case of a 39-year-old woman with left vulvar mass of 6 years duration that progressively increased in size. The patient reported having pressure and discomfort, especially during movement, but reported no pain. Lipoma was initially suspected. Surgical excision was performed and histopathological examination revealed a well-differentiated myxoid liposarcoma. The base and excised margins of the tumor were free of malignant cells. Post-operative course was uneventful and she was discharged in a satisfactory condition. The patient had been under regular follow-up and is currently symptom- and recurrence-free. We also review other cases of vulvar liposarcoma to further comprehend characteristics of this rare malignant tumor. CONCLUSIONS Liposarcoma of the vulva occurs very rarely, but clinicians and pathologists should always consider it as a differential diagnosis when presented with vulvar mass. Biopsy of a vulvar mass is crucial. Surgical excision remains the mainstay of treatment. Adjuvant radiotherapy may be considered in certain cases. Comprehensive follow-up for recurrences or metastasis is recommended throughout life.


Assuntos
Lipoma , Lipossarcoma Mixoide , Lipossarcoma , Doenças da Vulva , Neoplasias Vulvares , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Lipoma/patologia , Lipossarcoma Mixoide/diagnóstico , Lipossarcoma Mixoide/patologia , Vulva/patologia , Neoplasias Vulvares/diagnóstico , Neoplasias Vulvares/patologia , Neoplasias Vulvares/cirurgia
11.
In Vivo ; 36(6): 2654-2661, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36309352

RESUMO

BACKGROUND/AIM: The translocation t(9;12) (p22;q14~15) has been reported in lipomas, pleomorphic adenomas, a myolipoma, two chondroid hamartomas, and two uterine leiomyomas. In lipomas and pleomorphic adenomas, the translocation fuses HMGA2 (12q14) with the NFIB gene from 9p22; in myolipoma, it fuses HMGA2 with C9orf92 from 9p22; and in chondroid hamartomas, fluorescence in situ hybridization (FISH) investigations showed the chromosomal aberration to cause intragenic rearrangement of HMGA2. The translocation's molecular consequence in a uterine leiomyoma is described here. MATERIALS AND METHODS: A typical leiomyoma was investigated using banding cytogenetics, FISH, RNA sequencing, reverse transcription polymerase chain reaction and Sanger sequencing. RESULTS: A single translocation, t(9;12)(p22;q14) leading to an HMGA2::BNC2 chimera, was found in tumor cells. A sequence of the untranslated part of exon 5 of HMGA2 (nucleotide 1035 in the NCBI reference sequence NM_003483.4) had fused with a sequence from the untranslated part of exon 7 of BNC2 from 9p22 (nucleotide 9284 in reference sequence NM_017637.6). CONCLUSION: At the molecular level, the t(9;12)(p22;q14~15) found in several benign tumors appears to be heterogeneous fusing HMGA2 with either BNC2, C9orf92 or NFIB which all three map close to one another within a 3 Mbp region in 9p22. Because the fusion point in HMGA2 in the present tumor lays downstream from the first Let-7 miRNA consensus binding site, we conclude that deletion of the first Let-7 miRNA binding site is not important for the transcriptional upregulation of HMGA2 caused by the genomic rearrangement.


Assuntos
Hamartoma , Leiomioma , Lipoma , MicroRNAs , Humanos , Hibridização in Situ Fluorescente , Leiomioma/genética , Lipoma/patologia , Translocação Genética , Aberrações Cromossômicas , Hamartoma/genética , Nucleotídeos , Proteínas de Ligação a DNA/genética
12.
World J Gastroenterol ; 28(34): 5086-5092, 2022 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-36160650

RESUMO

BACKGROUND: Gastrointestinal (GI) lipomas are benign submucosal tumors of mature adipocytes that arise mainly in the colon and stomach, sometimes in the ileum and jejunum, and rarely in the duodenum. Patients with symptomatic lipomas require endoscopic or surgical treatment. Spontaneous expulsion of lipomas after biopsy is a rare condition that has limited case reports. CASE SUMMARY: A 56-year-old man presented to our hospital with intermittent postprandial epigastric fullness. Esophagogastroduodenoscopy (EGD) revealed a 10-mm soft yellowish submucosal lesion with the "pillow sign," located in the second portion of duodenum. Endoscopic ultrasonography (EUS) using a 12-MHz catheter probe showed a hyperechoic, homogenous, and round solid lesion (OLYMPUS EUS EU-ME2, UM-DP12-25R, 12-MHz radial miniprobe, Olympus Corporation, Tokyo, Japan). Deep biopsy was performed using the bite-on-bite technique with forceps. Histological examination was compatible with submucosal lipoma. The lesion spontaneously expelled 12 d after the biopsy. Follow-up EUS performed after 2 mo confirmed this condition. CONCLUSION: Deep biopsy could lead to spontaneous GI lipoma expulsion. This might be the first step in lipoma diagnosis and treatment.


Assuntos
Lipoma , Biópsia , Duodeno/diagnóstico por imagem , Duodeno/patologia , Endossonografia , Humanos , Lipoma/patologia , Masculino , Pessoa de Meia-Idade , Estômago/patologia
13.
Surg Clin North Am ; 102(4): 637-656, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35952693

RESUMO

Lipomatous tumors are among the most common soft tissue lesions encountered by the general surgeon. Shared history and clinical presentation make differentiation between benign lipomas and low-grade liposarcomas a diagnostic dilemma. This article reviews the epidemiology, clinical history, diagnostic workup, management, natural history, and surveillance of benign lipomas and atypical lipomatous tumors/well-differentiated liposarcomas. Although it is important that aggressive, potentially malignant atypical lipomatous tumors and liposarcomas be managed in a multidisciplinary, preferably high-volume setting, it is equally as important for the nonspecialist general surgeon to be familiar with lipoma and its doppelganger-the well-differentiated liposarcoma.


Assuntos
Lipoma , Lipossarcoma , Neoplasias de Tecidos Moles , Humanos , Lipoma/diagnóstico , Lipoma/patologia , Lipoma/cirurgia , Lipossarcoma/diagnóstico , Lipossarcoma/patologia , Lipossarcoma/cirurgia , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/cirurgia
15.
Pan Afr Med J ; 41: 336, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35865836

RESUMO

Lipoma is a common tumor of soft tissue with rare occurrence in oral cavity accounting for only 1-4% of benign oral tumours. It may be noticed only during routine dental examinations. Most of them rarely cause pain, resulting in delay to seek treatment. Lipoma of the oral cavity may occur in any region. The buccal mucosa, tongue, and floor of the mouth are among the common locations. A case of large intraoral lipoma occurring in mental region in a 60-year-old female patient is reported. It was treated surgically under local anesthesia, and 6 month follow up showed excellent healing without any recurrence.


Assuntos
Lipoma , Neoplasias Bucais , Anestesia Local , Feminino , Humanos , Lipoma/diagnóstico , Lipoma/patologia , Lipoma/cirurgia , Pessoa de Meia-Idade , Mucosa Bucal/patologia , Neoplasias Bucais/diagnóstico , Neoplasias Bucais/patologia , Neoplasias Bucais/cirurgia , Cicatrização
16.
Med Mol Morphol ; 55(4): 323-328, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-35779129

RESUMO

Atypical spindle cell/pleomorphic lipomatous tumor (ASPLT) is a new entity of benign adipocytic tumor that spans a wide spectrum of histology from adipocytic to spindle cell/pleomorphic tumors. The latter non-adipocytic component rarely shows sarcomatous features although ASPLTs are not thought to dedifferentiate. A 78-year-old woman with ASPLT in the left thigh had a sarcomatous component with high mitotic activity and Ki-67 labeling index (LI) mimicking dedifferentiated liposarcoma. The adipocytic component consisted of various-sized adipocytic cells with few lipoblasts. The sarcomatous component consisted of a fascicular proliferation of atypical spindle cells with scattered large bizarre and multinucleated giant cells. Mitotic figures including atypical mitoses were frequently observed. Immunohistochemically, the tumor cells were positive for cluster of differentiation 34 but not mouse double minute 2 homolog (MDM2), cyclin-dependent kinase 4 (CDK4), or retinoblastoma (Rb) protein. Ki-67 LI in the sarcomatous component reached 40%. MDM2 and CDK4 genes were not amplified and 13q14 including the RB1 locus was deleted according to fluorescence in situ hybridization. The patient is alive with no evidence of local recurrence or distant metastasis 3.5 years after surgery. As ASPLT may exhibit morphological variation, it is important to rule out dedifferentiated liposarcoma with careful pathological examination.


Assuntos
Lipoma , Lipossarcoma , Feminino , Humanos , Idoso , Quinase 4 Dependente de Ciclina/genética , Antígeno Ki-67/genética , Hibridização in Situ Fluorescente , Biomarcadores Tumorais/genética , Lipossarcoma/diagnóstico , Lipossarcoma/genética , Lipossarcoma/patologia , Lipoma/diagnóstico , Lipoma/genética , Lipoma/patologia
17.
World J Surg Oncol ; 20(1): 184, 2022 Jun 08.
Artigo em Inglês | MEDLINE | ID: mdl-35676721

RESUMO

BACKGROUND: According to guidelines, every soft tissue tumor (STT) larger than 3 cm should be biopsied before definitive resection. Advances in magnetic resonance imaging (MRI) improve the possibility to give a provisional diagnosis of the tumor's entity. Can lipomas and atypical lipomatous tumors (ALTs) of the extremities therefore be primarily marginally resected based on interpretation of MR images without a previous biopsy?. METHODS: In this retrospective, single-center study, 240 patients with the suspicion of a lipomatous tumor in MRI and surgical treatment in our institution between 2011 and 2020 were included. MR imaging was performed before surgery. All resected specimens underwent histopathological analysis. RESULTS: The collective comprised 142 tumors that were suspected as lipoma or ALT by the radiologist and underwent primary marginal resection (PMR). One case had myxoid liposarcoma that was underestimated on MRI and needed radical follow-up resection. One-hundred forty-one patients were cured after PMR. Ninety-eight patients were biopsied initially and in 93 cases resected afterwards according to the necessary oncological margins. CONCLUSION: In our institution, PMR is performed if a lipoma or ALT is suspected on MR imaging. Our treatment method and the diagnostic algorithm are presented. Primary resection spares patients from one surgical procedure, but a slight risk for underestimation of the tumor remains.


Assuntos
Lipoma , Lipossarcoma , Neoplasias de Tecidos Moles , Adulto , Biópsia , Diagnóstico Diferencial , Humanos , Lipoma/diagnóstico , Lipoma/patologia , Lipoma/cirurgia , Lipossarcoma/cirurgia , Estudos Retrospectivos , Neoplasias de Tecidos Moles/cirurgia
18.
J Coll Physicians Surg Pak ; 32(6): 814-816, 2022 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-35686419

RESUMO

Lipomas are benign mesenchymal tumors that comprise almost one-half of all soft tissue tumors. Lipomas can occur at any site where fat cells are present but are rare in the oral cavity, especially the tongue, which is a very rare site. Lipoma has several variants. Fibrolipoma is a rare variant and accounts for 25-40% of lipomas of the tongue. In only 14 cases, the diagnosis of fibrolipoma has been made histologically. Most cases of lipomas occur above 40 years of age. Herein, we report a case of fibrolipoma of the tongue in a young female of 18 years. The patient presented with complaint of swelling on the dorsum of the tongue for 8 years. The swelling was surgically excised and microscopically a diagnosis of fibrolipoma was made. In conclusion, oral lipomas especially lingual lipomas are a rare entity. Although oral lipomas mostly occur above 40 years of age, they can occur at a younger age. Key Words: Fibrolipoma, Tongue, Histopathology.


Assuntos
Lipoma , Dorso/patologia , Feminino , Humanos , Lipoma/diagnóstico , Lipoma/patologia , Lipoma/cirurgia , Língua/patologia , Língua/cirurgia
19.
J Comput Assist Tomogr ; 46(3): 434-439, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35575653

RESUMO

OBJECTIVE: Recent studies have indicated that intraosseous lipomas originate from simple bone cysts of the calcaneus. This study evaluates computed tomography (CT) and magnetic resonance imaging (MRI) findings of calcaneal cysts and lipomas in pediatric and adult populations. METHODS: Forty-six patients with bone lesions located in the anterior portion of the calcaneus beneath the talocalcaneal joint, who underwent CT and/or MRI, were enrolled in this study. The imaging characteristics were retrospectively reviewed and compared between the pediatric (aged 18 years or younger; n = 29) and adult (aged 19 years or older; n = 17) groups. RESULTS: On CT images, water/soft tissue attenuation alone was more frequent in the pediatric group than in the adult group (84% vs 13%, respectively; P < 0.01), whereas the combined water/soft tissue and fat attenuation (11% vs 47%, respectively; P < 0.05) and fat attenuation alone (5% vs 40%, respectively; P < 0.05) were less frequent in the pediatric group than in the adult group. On MRI, cystic components alone were more frequent in the pediatric group than in the adult group (88% vs 13%, respectively; P < 0.01), whereas the combined cystic and fat components (8% vs 38%, respectively; P < 0.05) and fat components alone (4% vs 50%, respectively; P < 0.01) were less frequent in the pediatric group than in the adult group. CONCLUSIONS: Calcaneal cysts were more frequent in the pediatric group, whereas calcaneal lipomas were more frequent in the adult group. These results could be additional evidence that intraosseous lipomas originate from simple bone cysts of the calcaneus.


Assuntos
Cistos Ósseos , Neoplasias Ósseas , Calcâneo , Lipoma , Adulto , Cistos Ósseos/complicações , Cistos Ósseos/diagnóstico por imagem , Cistos Ósseos/patologia , Neoplasias Ósseas/complicações , Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Ósseas/patologia , Calcâneo/diagnóstico por imagem , Calcâneo/patologia , Criança , Humanos , Lipoma/complicações , Lipoma/diagnóstico por imagem , Lipoma/patologia , Imageamento por Ressonância Magnética , Estudos Retrospectivos , Água
20.
Am J Dermatopathol ; 44(10): 764-767, 2022 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-35503875

RESUMO

ABSTRACT: A 58-year-old man presented with a lesion on the nose suspicious for basal cell carcinoma. An initial biopsy specimen reviewed at an outside institution showed a cytologically atypical spindle cell proliferation that lacked expression of cytokeratins or melanocytic markers. The resulting differential diagnosis included atypical fibroxanthoma and pleomorphic dermal sarcoma. Histopathologic examination of the excision specimen at our institution revealed an intradermal pleomorphic and spindle cell tumor which extended into underlying skeletal muscle. The tumor was associated with a fibromyxoid stroma, scattered adipocytes, and hyperplastic folliculosebaceous epithelium at the periphery. The pleomorphic tumor cells showed hyperchromatic nuclei with smudgy chromatin, and no mitotic activity was detected. Overall, the cellularity was less than would be expected for atypical fibroxanthoma/pleomorphic dermal sarcoma. Furthermore, the tumor cells were strongly positive for CD34 and showed diffuse loss of retinoblastoma protein by immunohistochemistry. Consequently, a diagnosis of benign CD34-positive pleomorphic spindle cell tumor was rendered, with features overlapping between spindle cell/pleomorphic lipoma and trichodiscoma. Subsequent single-nucleotide pleomorphism array testing revealed heterozygous loss of chromosome 13q in a region that spanned the RB1 locus and copy number loss at 16q, favoring that the proliferation in fact represents a spindle cell/pleomorphic lipoma with trichodiscoma-like epithelial induction. This case highlights an important diagnostic pitfall that may be avoided by recognizing characteristic architectural and cytologic features of this spectrum of lesions.


Assuntos
Neoplasias Ósseas , Histiocitoma Fibroso Maligno , Lipoma , Neoplasias Cutâneas , Biomarcadores Tumorais/genética , Biomarcadores Tumorais/metabolismo , Cromatina , Diagnóstico Diferencial , Humanos , Hiperplasia , Lipoma/patologia , Masculino , Pessoa de Meia-Idade , Nucleotídeos , Proteína do Retinoblastoma/genética , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/metabolismo
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