Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 4.754
Filtrar
1.
Biomed Res Int ; 2021: 4331250, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34485512

RESUMO

Excision is the gold standard for lipomas. Patients desire minimal scars, but minimal incisions can increase complications and produce hypertrophic scars. We propose an algorithmic method named the minimal one-third incision and four-step extraction method (MOTIF) for lipoma excision. This retrospective study analyzed lipomas surgically excised using the MOTIF method at our institution between January 2016 and December 2018. A total of 112 lipomas were included. The complication rates and Vancouver Scar Scale (VSS) for three different size groups (<3 cm, 3 ~ 6 cm, >6 cm) were compared. Complete excision of all palpable lipomas was achieved with this approach. There were two seromas, two hematomas, and one postoperative nerve injury. There was no difference in complication rates and VSS between the three size groups. The MOTIF method is a cost-effective, reliable, and cosmetically pleasing method that can be applied to all lipomas regardless of size and location.


Assuntos
Cicatriz Hipertrófica/patologia , Lipoma/cirurgia , Procedimentos Cirúrgicos Minimamente Invasivos/efeitos adversos , Complicações Pós-Operatórias/patologia , Neoplasias Cutâneas/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Cicatriz Hipertrófica/etiologia , Feminino , Humanos , Lipoma/patologia , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/etiologia , Estudos Retrospectivos , Neoplasias Cutâneas/patologia , Resultado do Tratamento , Adulto Jovem
2.
Pan Afr Med J ; 38: 342, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34367421

RESUMO

Duodenal lipoma is a rare location of visceral lipomas, most are found incidentally via endoscopy or surgery and usually are asymptomatic. We report the case of a 58-year-old patient with an active bleeding duodenal lipoma. Although endoscopic treatment was scheduled initially, surgical intervention ultimately was indicated due to large size of tumor.


Assuntos
Neoplasias Duodenais/diagnóstico , Hemorragia Gastrointestinal/etiologia , Lipoma/diagnóstico , Neoplasias Duodenais/complicações , Neoplasias Duodenais/patologia , Humanos , Lipoma/complicações , Lipoma/patologia , Masculino , Pessoa de Meia-Idade
3.
Medicine (Baltimore) ; 100(33): e26944, 2021 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-34414955

RESUMO

BACKGROUND: To explore the diagnostic value of computed tomography (CT) imaging for duodenal lipoma and the potential clinical significance of the findings. METHODS: Clinicopathological and CT data from 57 patients, who were diagnosed with duodenal lipoma at the first affiliated Hospital of Zhengzhou University (Zhengzhou, China) between June 2014 and March 2019, were retrospectively reviewed. Data collected included location and size of the tumor, morphological manifestations (shape, density, boundary), concomitant diseases, pathology and gastroscopy results, and follow-up. Follow-up was performed via telephone, and surgical patients were followed-up for recurrence, metastasis and tumor size, and morphological changes. The follow-up period was up to January 2019. RESULTS: Of the 57 patients with duodenal lipoma, contrast-enhanced scanning was performed in 7 cases. The tumor was located in the descending duodenum in 33 cases, the ascending in 4 cases, the horizontal in 16 cases, and the bulb in 4 cases. Mean tumor size was 13.0 ±â€Š5.8 mm. CT morphological features of the tumor were as follows: tumor shape, round, quasi-round, or oval (n = 42); long strip (n = 3); nodular (n = 2); triangular (n = 1); and irregular lobulated (n = 9). Among the 57 patients, tumor density was homogeneous in 52 cases, inhomogeneous in 4 cases, and nodular with calcification in 1 case. The tumor boundary was classified as clear and with no capsule. Diseases concomitant with the tumor were as follows: gastritis (n = 23), gastric adenocarcinoma (n = 1), and gastric lymphoma (n = 1). Esophageal disease was found in 16 cases, including reflux esophagitis (n = 12) and esophageal cancer (n = 4). There were 13 cases of gallbladder and biliary disease, including cholecystolithiasis and cholecystitis (n = 9), common bile duct disease (n = 2), colorectal cancer (n = 4), lung cancer (n = 2), duodenal carcinoma with obstruction (n = 1), and ureteral space narrowing (n = 1). CONCLUSION: CT was an effective, non-invasive method for diagnosis of duodenal lipoma. CT imaging could clearly discern location, size, shape, and nature of duodenal lipomas. Duodenal lipoma can be associated with digestive tract inflammatory diseases and tumors in different locations, and its diagnosis is potentially valuable for their prevention and treatment.


Assuntos
Neoplasias Duodenais/diagnóstico por imagem , Lipoma/diagnóstico por imagem , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Neoplasias Duodenais/diagnóstico , Neoplasias Duodenais/patologia , Duodeno/diagnóstico por imagem , Duodeno/patologia , Feminino , Humanos , Lipoma/diagnóstico , Lipoma/patologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Tomografia Computadorizada por Raios X
4.
Ann R Coll Surg Engl ; 103(7): e212-e215, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34192501

RESUMO

We present a case of a man with a background of myasthenia gravis who presented with a neck lump, which was diagnosed as thyrolipomatosis in continuity with a very large thymolipoma. Following removal of these lesions, the patient's myaesthenic symptoms improved. While thymolipomas are often seen in the context of myasthenia gravis, thyrolipomatosis is a rare entity and to our knowledge the concurrent finding of both lesions with myasthenia gravis has never been reported. We highlight the important imaging features of both entities and the clinical importance of recognising them.


Assuntos
Lipoma/cirurgia , Lipomatose/cirurgia , Miastenia Gravis/terapia , Neoplasias do Timo/cirurgia , Doenças da Glândula Tireoide/cirurgia , Adulto , Humanos , Lipoma/diagnóstico , Lipoma/patologia , Lipomatose/diagnóstico , Lipomatose/patologia , Masculino , Miastenia Gravis/etiologia , Prednisolona/uso terapêutico , Brometo de Piridostigmina/uso terapêutico , Timectomia , Timo/diagnóstico por imagem , Timo/patologia , Timo/cirurgia , Neoplasias do Timo/diagnóstico , Neoplasias do Timo/patologia , Doenças da Glândula Tireoide/diagnóstico , Doenças da Glândula Tireoide/patologia , Glândula Tireoide/diagnóstico por imagem , Glândula Tireoide/patologia , Glândula Tireoide/cirurgia , Tireoidectomia , Tomografia Computadorizada por Raios X , Resultado do Tratamento
5.
J Ayub Med Coll Abbottabad ; 33(2): 339-340, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34137557

RESUMO

Intraperitoneal Lipomas presenting as huge abdominal mass are uncommon in paediatric age group. We report case of an 11 months old male child, who presented with abdominal distension and constipation. Initial investigations including CT scan and Trucut biopsy of lesion failed to delineate nature of tumour. However, upon surgical excision it turned out to be a rare tumour of mesenteric origin.


Assuntos
Lipoma/diagnóstico , Mesentério/patologia , Abdome/patologia , Biópsia , Constipação Intestinal/complicações , Humanos , Lactente , Lipoma/complicações , Lipoma/patologia , Lipoma/cirurgia , Masculino
6.
Medicine (Baltimore) ; 100(18): e25782, 2021 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-33950973

RESUMO

RATIONALE: Spindle cell lipoma is a rare, uncommon type of benign lipomatous tumor, a distinct group of lipomas composed of mature adipocytes, uniform spindle cells, and multinucleated giant cells associated with ropey collagen. Immunohistochemically, spindle cell lipoma is characterized by the diffuse expression of CD34. PATIENT CONCERNS: We present a rare case of a 56-year-old man who complained of vomiting out of a smooth and giant mass in the oral cavity provoked by an intra-abdominal pressure increase. Oral examination revealed an elongated mass protruding from the mouth. Computed tomography of the patient showed a mass from left pyriform to oral cavity, with 2.38 × 2.78 × 16.86 cm in size. The flexible fiberscope showed that the pedicle of the elongated mass originated from the posterior wall of the hypopharynx, corresponding to the left pyriform fossa. DIAGNOSIS: Histopathologically, the tumor was mainly composed of hyperplastic adipocytes, admixed with small blood vessels, and scattered inside adipose tissue spindle cells. The immunohistochemical profile revealed positivity of spindle cells for CD34, negativity for S100, and low proliferation with Ki67, which confirmed the diagnosis of spindle cell lipoma and revealed its benign behavior. INTERVENTIONS: The patient underwent hypopharyngeal mass resection using transoral suspension laryngoscopy. OUTCOMES: No recurrence was found after 5 months of follow-up. LESSONS: Spindle cell lipoma is difficult to diagnose early because of slow growth and subtle symptomatology. This entity should be differentiated from several benign or malignant subtypes of lipomas, including liposarcomas. In this case, the spindle cell lipoma is large and originates from the hypopharynx, which is a rare entity and presents with atypical symptoms. This case gave rise to further studies on the clinical and pathologic characteristics of this tumor in the future.


Assuntos
Neoplasias Hipofaríngeas/diagnóstico , Hipofaringe/patologia , Laringoscopia , Lipoma/diagnóstico , Antígenos CD34/análise , Antígenos CD34/metabolismo , Diagnóstico Diferencial , Humanos , Neoplasias Hipofaríngeas/patologia , Neoplasias Hipofaríngeas/cirurgia , Hipofaringe/diagnóstico por imagem , Hipofaringe/cirurgia , Imuno-Histoquímica , Lipoma/patologia , Lipoma/cirurgia , Lipossarcoma/diagnóstico , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X
7.
Sci Rep ; 11(1): 8493, 2021 04 19.
Artigo em Inglês | MEDLINE | ID: mdl-33875750

RESUMO

Renal angiomyolipomas hemorrhage is associated with their size and vascular constitution. The effects of sirolimus on different components of angiomyolipomas was analyzed in patients with tuberous sclerosis complex, sporadic lymphangioleiomyomatosis and multiple sporadic angiomyolipomas. Thirty angiomyolipomas from 14 patients treated with sirolimus were retrospectively evaluated. A Hounsfield-unit threshold was used to classify angiomyolipomas in fat-rich, fat-poor and intermediate-fat tumors, and to categorize tumor compartments in fat rich, fat poor, intermediate fat and highly vascularized. Diameter variations were measured to assess the effects on aneurysmatic/ectatic vascular formations. Volume reduction following treatment with sirolimus was higher in fat-poor than fat-rich angiomyolipomas. Tumor reduction was mainly determined by decrease of the fat-poor and highly-vascularized compartments while the volume of the fat-rich compartment increased. Broad liposubstitution was observed in some tumors. A median reduction of 100% (75 to 100) in the diameter of aneurysmatic/ectatic vascular structures was observed. Our study showed that sirolimus reduces the size of angiomyolipomas by decreasing primarily their highly-vascularized and fat-poor compartments. This effect is associated with a remarkable reduction of tumoral aneurysms/ectatic vessels, revealing the likely mechanism responsible for the risk-decreasing effect of mTOR inhibitors on angiomyolipoma bleeding. These findings support the role of mTOR in the development of angiomyolipoma blood vessels.


Assuntos
Angiomiolipoma/tratamento farmacológico , Antibióticos Antineoplásicos/uso terapêutico , Neoplasias Renais/tratamento farmacológico , Lipoma/tratamento farmacológico , Linfangioleiomiomatose/tratamento farmacológico , Sirolimo/uso terapêutico , Esclerose Tuberosa/tratamento farmacológico , Adulto , Angiomiolipoma/patologia , Feminino , Seguimentos , Humanos , Neoplasias Renais/patologia , Lipoma/patologia , Linfangioleiomiomatose/patologia , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Retrospectivos , Esclerose Tuberosa/patologia , Adulto Jovem
8.
Diagn Pathol ; 16(1): 15, 2021 Feb 21.
Artigo em Inglês | MEDLINE | ID: mdl-33612094

RESUMO

BACKGROUND: A 52-year-old woman presented with shortness of breath and cough. An endobronchial sialolipoma was found at the left entrance of the main bronchus. Sialolipoma is an exceedingly rare type of lipoma reported of the minor salivary glands, especially within the bronchus. CASE PRESENTATION: A 52-year-old woman presented with shortness of breath and cough with 6 months´ evolution. Endobronchial endoscopy revealed a tumour at the left entrance of the main bronchus. The entire removal of the tumour was removed using a cryoprobe device. Pathological examination showed a tumour consistent with the diagnosis of sialolipoma due to the presence of mature adipose cells blended with acinar, ductal, basal, and myoepithelial cells. The patient had a favourable outcome. CONCLUSION: The infrequent tracheobronchial presentation of this tumour can be challenging for correct diagnosis.


Assuntos
Endoscopia/métodos , Lipoma/patologia , Glândulas Salivares Menores/patologia , Neoplasias da Glândula Submandibular/patologia , Adipócitos/patologia , Diagnóstico Diferencial , Feminino , Humanos , Lipoma/diagnóstico , Pessoa de Meia-Idade , Glândulas Salivares Menores/diagnóstico por imagem , Neoplasias da Glândula Submandibular/diagnóstico
9.
Medicine (Baltimore) ; 100(6): e24711, 2021 Feb 12.
Artigo em Inglês | MEDLINE | ID: mdl-33578611

RESUMO

RATIONALE: Recurrent liposarcoma, previously confirmed as lipoma, has rarely been reported. However, the risk factors for recurrence and the correlation between benign lipoma and malignant liposarcoma remain unclear. In this case study, we suggest a precise diagnostic strategy to minimize recurrence and malignant transformation. PATIENT CONCERNS: A 60-year-old male patient with a history of left chest wall swelling without any symptoms underwent excisional surgery, and the mass was confirmed as a benign lipoma in 2015. In 2019, the patient returned to the hospital with symptoms of a palpable mass on the left chest wall. DIAGNOSIS: The mass was considered a recurrent lipomatous tumor with the possibility of malignant transformation. Magnetic resonance imaging (MRI) revealed a deep-seated, septate, intramuscular, irregular margin, and large lipomatous tumor invading the ribs, pleura, and adjacent muscle, suggestive of malignancy. The MRI findings were similar to those 4 years ago, except for margin irregularity and invasion to adjacent tissue. INTERVENTIONS: Wide en bloc excisions encompassing the 5th to 7th ribs, pleura, and adjacent muscle were followed by reconstruction with a pedicled latissimus dorsi muscle flap. OUTCOMES: The recurrent large lipomatous tumor was confirmed as well-differentiated liposarcomas through histological and MDM2-FISH immunohistochemical staining. Postoperatively, follow-up visits continued for 1.5 years without recurrence. LESSONS: We suggest that deep-seated, septate, and giant lipomatous tumors should be considered as risk factors for recurrence with the possibility of malignancy and misdiagnosis. It is important to inform patients of all these possibilities and plan close and long-term follow-up.


Assuntos
Lipoma/patologia , Lipossarcoma/patologia , Recidiva Local de Neoplasia/patologia , Neoplasias Torácicas/patologia , Parede Torácica/patologia , Humanos , Lipoma/diagnóstico por imagem , Lipoma/cirurgia , Lipossarcoma/diagnóstico por imagem , Lipossarcoma/cirurgia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/diagnóstico por imagem , Recidiva Local de Neoplasia/cirurgia , Neoplasias Torácicas/diagnóstico por imagem , Neoplasias Torácicas/cirurgia , Parede Torácica/diagnóstico por imagem , Parede Torácica/cirurgia
10.
AJR Am J Roentgenol ; 216(4): 997-1002, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33624523

RESUMO

OBJECTIVE. Diagnostic accuracy of core needle biopsy (CNB) for adipocytic tumors can be low because of sampling error from these often large, heterogeneous lesions. The purpose of this study was to evaluate the diagnostic accuracy of image-guided CNB for various adipocytic tumors in comparison with excisional pathology. MATERIALS AND METHODS. Adipocytic tumors (n = 77) of all adult patients undergoing image-guided CNB and subsequent surgical excision of an adipocytic tumor at a tertiary referral center between 2005 and 2019 were studied. To determine concordance, we compared pathologic diagnoses based on CNB to the reference standard of pathologic diagnoses after surgical excision. Tumors were divided into three categories (benign lipomatous tumors [lipoma, lipoma variants, hibernomas], atypical lipomatous tumors [ALTs] or well-differentiated liposarcomas [WDLs], and higher grade liposarcomas [myxoid, dedifferentiated, pleomorphic]), and diagnostic accuracy was calculated for each category. RESULTS. In 73 of 77 adipocytic tumors (95%), diagnosis at CNB and diagnosis after excision were concordant. Accuracy of diagnosis was poorer for ALTs and WDLs than for the other two categories, and the difference was statistically significant (p < .002). For the 29 benign lipomatous tumors and the 27 higher-grade liposarcomas, diagnoses at CNB and after excision were concordant in all cases (100%). Seventeen of the 21 tumors (81%) diagnosed as ALTs or WDLs at CNB had a concordant diagnosis after excision; four of the 21 were upgraded (dedifferentiated liposarcoma, n = 3; myxoid liposarcoma, n = 1). CONCLUSION. CNB provides high diagnostic accuracy for adipocytic tumors, particularly for benign lipomatous tumors and higher grade liposarcomas. However, though still high at 81%, diagnostic accuracy of CNB is not as high for tumors diagnosed as ALTs or WDLs. Awareness of this limitation is important when determining management, particularly of cases of ALT or WDL for which surgery is not planned.


Assuntos
Biópsia com Agulha de Grande Calibre/métodos , Biópsia Guiada por Imagem/métodos , Neoplasias Lipomatosas/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Lipoma/diagnóstico por imagem , Lipoma/patologia , Lipossarcoma/diagnóstico , Lipossarcoma/patologia , Masculino , Pessoa de Meia-Idade , Neoplasias Lipomatosas/diagnóstico , Reprodutibilidade dos Testes , Estudos Retrospectivos
11.
BMJ Case Rep ; 14(2)2021 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-33542010

RESUMO

Lipomas of the large intestine are uncommon tumour. They are often innocuous and do not cause any clinical problem, particularly if they are small (<2 cm) is size. However, they can give rise to significant clinical symptoms if they become large and can be mistaken for colorectal carcinoma. Herein, a giant submucosal lipoma of descending colon is described, which was preoperatively suspected of carcinoma and underwent left hemicolectomy. The diagnosis was only reached after pathological examination of the resected tumour. The case highlights that a large colonic lipoma still poses diagnostic difficulty. Accurate diagnosis of the lipomas is important as they can be removed by endoscopic polypectomy or segmental resection, obviating the need of unnecessary major surgical resection.


Assuntos
Colectomia , Colo Descendente/cirurgia , Neoplasias do Colo/patologia , Diagnóstico Diferencial , Lipoma , Colonoscopia , Feminino , Humanos , Lipoma/patologia , Lipoma/cirurgia , Pessoa de Meia-Idade
12.
Arch. Soc. Esp. Oftalmol ; 96(1): 48-51, ene. 2021. ilus
Artigo em Espanhol | IBECS | ID: ibc-200185

RESUMO

El propósito de este artículo es describir un caso de agenesia lagrimal congénita unilateral en una niña de 7 años con síntomas oculares, ausencia de secreción lagrimal y una tumoración conjuntival en el ángulo superoexterno del ojo derecho. La agudeza visual era de 20/20 en ambos ojos. El ojo derecho presentaba secreción mucosa, erosiones y filamentos corneales. La anamnesis, la exploración física y las pruebas analíticas descartaron enfermedades sistémicas asociadas a la alacrimia congénita, así como enfermedades reumatológicas, inmunológicas o infecciosas. La resonancia nuclear magnética con diversas técnicas de supresión grasa mostró la ausencia de glándula lagrimal derecha y la presencia de una tumoración compatible con lipoma. Este caso, para nuestro conocimiento, representa la primera comunicación de una agenesia unilateral de glándula lagrimal combinada con un lipoma


The purpose of this report is to describe a case of a unilateral congenital absence of the lacrimal gland in a 7-year-old girl with ocular symptoms, no tear production and a conjunctival tumour at the supero-external angle of the right eye. The visual acuity was 20/20 in both the eyes. The right eye showed mucous secretion, corneal erosions and filaments. Anamnesis, physical examination and clinical tests ruled out systemic diseases associated with congenital alacrima, as well as rheumatic, immunological and infectious diseases. Nuclear magnetic resonance, with various fat suppression techniques, demonstrated the absence of the right lacrimal gland and the presence of a tumour compatible with lipoma. This case, to our knowledge, is the first report of unilateral absence of the lacrimal gland combined with lipoma


Assuntos
Humanos , Feminino , Criança , Doenças do Aparelho Lacrimal/congênito , Doenças do Aparelho Lacrimal/diagnóstico , Aparelho Lacrimal/anormalidades , Glândulas Salivares/anormalidades , Lipoma/patologia , Acuidade Visual , Ceratoconjuntivite Seca/complicações , Espectroscopia de Ressonância Magnética , Plug Lacrimal , Lubrificantes Oftálmicos/uso terapêutico , Receptores de Hialuronatos/uso terapêutico , Soluções Oftálmicas/uso terapêutico , Ciclosporina/uso terapêutico
13.
Virchows Arch ; 479(3): 631-635, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33392798

RESUMO

Spindle cell lipoma, cellular angiofibroma and mammary myofibroblastoma are mesenchymal tumours that have overlapping morphological and immunophenotypic features. Aberrations in chromosome 13q14 have been identified as a recurrent feature. We report a unique case of a 69-year-old woman who metachronously developed all three tumours. She developed a peri-urethral and a recurrent peri-vaginal cellular angiofibroma at age 54 and 57, respectively, a spindle cell lipoma at age 62 and a mammary myofibroblastoma at age 69. Dual-colour interphase fluorescent in situ hybridisation (FISH) revealed losses of RB1 and FOXO1 (13q14LOH [loss of heterozygosity]) within neoplastic cells. There was also loss of retinoblastoma (Rb) protein expression. To our knowledge, this is the first report of these three tumours arising in the same patient. The genetic link between these tumours supports the hypothesis that they may arise from the same progenitor cells. However, further research is required to elucidate the precise pathogenetic link.


Assuntos
Angiofibroma/genética , Biomarcadores Tumorais/genética , Neoplasias da Mama/genética , Cromossomos Humanos Par 14 , Lipoma/genética , Perda de Heterozigosidade , Neoplasias de Tecido Muscular/genética , Segunda Neoplasia Primária/genética , Neoplasias Uretrais/genética , Neoplasias Vaginais/genética , Idoso , Angiofibroma/patologia , Neoplasias da Mama/patologia , Feminino , Proteína Forkhead Box O1/genética , Predisposição Genética para Doença , Humanos , Hibridização in Situ Fluorescente , Lipoma/patologia , Neoplasias de Tecido Muscular/patologia , Segunda Neoplasia Primária/patologia , Fenótipo , Proteínas de Ligação a Retinoblastoma/genética , Ubiquitina-Proteína Ligases/genética , Neoplasias Uretrais/patologia , Neoplasias Vaginais/patologia
15.
Hum Pathol ; 110: 12-19, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33406387

RESUMO

Although the morphologic diagnosis of hibernoma is usually straightforward, some hibernomas have atypical morphologic features, mimicking atypical lipomatous tumors/well-differentiated liposarcomas (ALT/WDLs). In addition, the multivacuolated brown fat cells may be mistaken for lipoblasts by pathologists, especially those without significant soft tissue tumor exposure. Thus, we continue to receive in consultation cases of hibernoma sent for MDM2 fluorescence in situ hybridization testing to exclude ALT/WDL. Testing hibernomas for MDM2 amplification, however, adds cost and delays the final diagnosis. Recently, we have noted expression of neprilysin (CD10, CALLA), a zinc-dependent metalloproteinase involved in the inactivation of various peptide hormones, in brown fat cells, and wished to explore the potential utility of this widely available, inexpensive ancillary test in the differential diagnosis of hibernoma. Formalin-fixed, paraffin-embedded tissue sections from well-characterized cases of hibernoma (n = 48), brown fat (n = 21), ALTs/WDLs (n = 17), pleomorphic liposarcomas (PLPSs) (n = 6), lipomas (n = 5), and fat necrosis (n = 5) were immunostained for CD10, using a commercially available antibody and routine laboratory protocols. CD10 expression was evaluated in both adipocytes and in surrounding stromal cells. The hibernomas occurred in 28 men and 20 women, ranging from 11 to 76 years of age and involved the extremities (n = 25), pelvis (n = 7), abdomen/pelvis/retroperitoneum (n = 7), head and neck region (n = 6), back (n = 2), and chest (n = 1). All showed diffuse, strong CD10 expression in multivacuolated brown fat cells and in the majority of adjacent univacuolated fat cells. Brown adipose tissue from various anatomic structures showed an identical pattern of immunoreactivity. In contrast, CD10 expression was present in the adipocytes of only 3 of 17 (18%) ALTs/WDLs and was absent in lipomas and fat necrosis. Lipoblasts expressed CD10 in 3 PLPSs. Expression of CD10 by surrounding fibroblastic stromal cells was more widespread, present in 13 hibernomas, 10 ALTs/WDLs, 1 instance of fat necrosis, 6 PLPSs, and 4 examples of brown fat. We conclude that immunohistochemistry for CD10 may represent a useful, rapid and inexpensive ancillary test in the differential diagnosis of hibernoma from potential morphologic mimics, especially when morphologic features favor hibernoma. CD10 expression in adipocytes, however, should be rigorously distinguished from fibroblastic stromal cell CD10 expression, a nonspecific finding.


Assuntos
Lipoma/metabolismo , Lipoma/patologia , Lipossarcoma/patologia , Neprilisina/metabolismo , Adipócitos/metabolismo , Adipócitos/patologia , Adolescente , Adulto , Idoso , Biomarcadores Tumorais/metabolismo , Criança , Diagnóstico Diferencial , Feminino , Humanos , Lipoma/diagnóstico , Lipossarcoma/diagnóstico , Lipossarcoma/metabolismo , Masculino , Pessoa de Meia-Idade , Proteínas Proto-Oncogênicas c-mdm2/genética , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/metabolismo , Neoplasias de Tecidos Moles/patologia , Adulto Jovem
16.
Med. oral patol. oral cir. bucal (Internet) ; 26(1): e36-e42, ene. 2021. tab, ilus, graf
Artigo em Inglês | IBECS | ID: ibc-200536

RESUMO

BACKGROUND: To investigate the relative frequency of localized mucosal swellings of the upper and lower labial mucosa, the clinical-pathological diagnosis agreement and whether patient's age and gender and tumor's site and size may raise the suspicion of neoplasm. MATERIAL AND METHODS: Retrospective analysis was performed on upper or lower labial mucosal tumors, histopathologically diagnosed between 2009-2018. The diagnostic categories developmental/reactive tumors, benign and malignant neoplasms were associated with patient's age and gender and tumor's site and size; clinical-pathological diagnosis agreement was, also, evaluated. RESULTS: Overall, 1000 (95.7%) developmental/reactive tumors, 35 (3.3%) benign and 10 (1%) malignant neoplasms were found. Upper/lower lip tumor ratio was 0.14:1. The diagnostic category was significantly associated with age (p < 0.0001), site (p < 0.0001) and diameter (p < 0.0001). Age ≥60 years, tumor's location on the upper lip and diameter >1cm were independent predictors for neoplasms. Patients presenting 2 or 3 of these variables were 20.2 times (p < 0.0001) or 33.6 times (p < 0.0001), respectively, more likely to have a neoplasm. Complete/partial agreement between clinical and pathological diagnosis was seen in 96.3% of the cases. CONCLUSIONS: Most lip tumors involve the lower lip and are reactive, but upper lip tumors measuring > 1 cm in patients ≥ 60 years have significantly higher probability to be neoplasms


No disponible


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias Labiais/epidemiologia , Neoplasias Labiais/patologia , Mucosa Bucal/patologia , Estudos Retrospectivos , Lipoma/epidemiologia , Lipoma/patologia , Adenoma/epidemiologia , Adenoma/patologia , Cistos/epidemiologia , Cistos/patologia , Distribuição por Idade e Sexo , Gradação de Tumores , Grécia/epidemiologia
17.
Med. oral patol. oral cir. bucal (Internet) ; 26(1): e90-e96, ene. 2021. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-200544

RESUMO

BACKGROUND: intraoral soft tissue lipomas are relatively uncommon mesenchymal neoplasms. Few papers have been published comparing the clinicopathological features of these tumors in different populations. The aim of the present study was to analyze the clinicopathological features from intraoral soft tissue lipomas diagnosed in a Brazilian population. MATERIAL AND METHODS: all cases diagnosed as intraoral soft tissue lipomas in an Oral Pathology laboratory from 2005 to 2019 were retrieved and descriptively analyzed; statistical analysis was performed for comparison of the clinical and demographic parameters. RESULTS: 91 intraoral lipomas were retrieved, including 56 lipomas, 30 fibrolipomas, 2 spindle cell lipomas, 2 angiolipomas, and 1 chondrolipoma. Mean age of the patients was 62.2 years and females represented 57.1% of the sample. Mean time of complaint was 45.4 months and mean size of the lesions was 16.2 millimeters. Buccal mucosa (38.8%), lower lip (18.8%) and tongue (16.5%) were the most commonly affected locations. Fibrolipomas were more common in females (p = 0,037) and presented as smaller lesions (p = 0,011) in comparison to lipomas. CONCLUSIONS: report of clinicopathological data from intraoral lipomas aid in establishing their differential diagnostic criteria and clinical profile in this specific location


No disponible


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Lipoma/patologia , Neoplasias Bucais/patologia , Neoplasias de Tecidos Moles/patologia , Lipoma/diagnóstico , Neoplasias Bucais/diagnóstico , Neoplasias de Tecidos Moles/diagnóstico , Diagnóstico Diferencial , Mucosa Bucal/patologia , Brasil , Estudos Retrospectivos
18.
Jt Dis Relat Surg ; 32(1): 230-233, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33463442

RESUMO

Lipoma is a common benign soft tissue tumor which rarely occurs in the hand. Lipomas of the hand seldomly cause pain or other symptoms. However, in certain areas, the mass effect from the lipoma may cause clinical symptoms. It rarely involves the deep areas such as synovial membrane and muscle and, sometimes, pressure on the peripheral nerves can cause pain and neurological symptoms. The treatment is surgical resection with a low rate of recurrence. However, the rate of recurrence is high in deep and infiltrating lipomas which preclude complete resection. In this article, we report a case of a large palmar lipoma arising from the flexor tenosynovium of the hand causing digital nerve compression.


Assuntos
Dedos/inervação , Lipoma , Neoplasias de Tecidos Moles , Idoso , Dissecação/métodos , Feminino , Mãos/diagnóstico por imagem , Mãos/patologia , Mãos/cirurgia , Humanos , Lipoma/complicações , Lipoma/patologia , Lipoma/cirurgia , Imageamento por Ressonância Magnética/métodos , Síndromes de Compressão Nervosa/etiologia , Síndromes de Compressão Nervosa/cirurgia , Nervos Periféricos/patologia , Neoplasias de Tecidos Moles/complicações , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/cirurgia , Membrana Sinovial/patologia , Tomografia Computadorizada por Raios X/métodos , Resultado do Tratamento
19.
J Pediatr Adolesc Gynecol ; 34(3): 421-423, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-33484846

RESUMO

BACKGROUND: Lipomatous tumors of the vulva are exceedingly rare, particularly in adolescents. We describe the work-up and management of an adolescent girl who presented with a large, well-vascularized vulvar mass. CASE: A 14-year-old girl presented with a large vulvar mass of unclear etiology. Magnetic resonance imaging of this mass revealed an ill-defined, well-vascularized mass with fat signal characteristics suggestive of a lipomatous tumor that was concerning for malignancy. We performed complete resection of the mass, and histologic evaluation revealed a vulvar hibernoma. There have been no signs of recurrence 1 year later. SUMMARY AND CONCLUSION: Although rare, a hibernoma of the vulvar region may present in adolescence and may be concerning for malignancy on imaging. Complete resection of these tumors is recommended for definitive diagnosis and treatment.


Assuntos
Lipoma/patologia , Neoplasias Vulvares/patologia , Adolescente , Feminino , Humanos , Lipoma/cirurgia , Imageamento por Ressonância Magnética , Neoplasias Vulvares/cirurgia
20.
BMC Surg ; 21(1): 30, 2021 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-33413245

RESUMO

BACKGROUND: A hibernoma, also known as a brown fat tumor, is a rare benign soft tissue tumor, which originates from brown adipose tissue remaining in the fetus after the gestational period. It is often detected in adult men, presenting as a painless slow-growing mass. Hibernomas of the thigh have been reported; however, motor and sensory disorders caused by the tumors compressing the femoral nerve have not been reported. We report a case of a histopathologically proven hibernoma that induced femoral mononeuropathy. CASE PRESENTATION: A 26-year-old man was admitted to the hospital due to a mass, approximately 11.0 × 9.0 × 4.0 cm in size, that had developed 5 years ago in the anterolateral aspect of the proximal thigh. Furthermore, he had a history of hypoesthesia 1 month prior to his admission. He had signs and symptoms of both a motor and sensory disorder, involving the anterior aspect of the right thigh and the medial aspect of the calf, along the distribution of the femoral nerve. During surgery, the femoral nerve was found to be compressed by the giant tumor. The resultant symptoms probably caused the patient to seek medical care. Marginal resection of the mass was performed by careful dissection, and the branches of the femoral nerve were spared. Histopathology examination showed findings suggestive of a hibernoma. At the 4-month follow-up, no femoral nerve compression was evident, and local tumor recurrence or metastasis was not found. CONCLUSIONS: Asymptomatic hibernomas do not require treatment; however, in cases of hibernomas with apparent symptoms, complete marginal surgical excision at an early stage is a treatment option because it is associated with a low risk of postoperative tumor recurrence.


Assuntos
Nervo Femoral/cirurgia , Neuropatia Femoral/diagnóstico por imagem , Neuropatia Femoral/cirurgia , Lipoma/complicações , Lipoma/patologia , Adulto , Neuropatia Femoral/etiologia , Neuropatia Femoral/patologia , Humanos , Lipoma/diagnóstico , Lipoma/cirurgia , Imageamento por Ressonância Magnética , Masculino , Recidiva Local de Neoplasia , Coxa da Perna , Resultado do Tratamento , Ultrassonografia Doppler em Cores
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...