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2.
BMJ Case Rep ; 12(5)2019 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-31068345

RESUMO

Intracranial lipoma is a relatively rare benign lesion. Many are incidental findings; however, some others may present with headache, hydrocephalus or other neurological symptoms; thus, correct diagnosis of this condition is important. These lesions are of high signal intensity on T2-weighted MRI and especially those close to cerebrospinal fluid (CSF) spaces, can easily be overlooked in the background of high signal intensity of CSF. Here, we present a case of tectal lipoma, with subsequent severe hydrocephalus and absence of septum pellucidum which was initially misinterpreted as a form of holoprosencephaly, due to inadequate attention to T1-weighted images.


Assuntos
Neoplasias Encefálicas/diagnóstico , Holoprosencefalia/patologia , Hidrocefalia/patologia , Lipoma/diagnóstico , Imagem por Ressonância Magnética , Derivação Ventriculoperitoneal , Neoplasias Encefálicas/fisiopatologia , Neoplasias Encefálicas/terapia , Pré-Escolar , Diagnóstico Diferencial , Holoprosencefalia/diagnóstico por imagem , Holoprosencefalia/terapia , Humanos , Hidrocefalia/diagnóstico por imagem , Hidrocefalia/terapia , Lipoma/fisiopatologia , Lipoma/terapia , Masculino , Teto do Mesencéfalo/patologia , Resultado do Tratamento
3.
Dermatol Clin ; 37(2): 229-239, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30850045

RESUMO

The discoveries of new genes underlying genetic skin diseases have occurred at a rapid pace, supported by advances in DNA sequencing technologies. These discoveries have translated to an improved understanding of disease mechanisms at a molecular level and identified new therapeutic options based on molecular targets. This article highlights just a few of these recent discoveries for a diverse group of skin diseases, including tuberous sclerosis complex, ichthyoses, overgrowth syndromes, interferonopathies, and basal cell nevus syndrome, and how this has translated into novel targeted therapies and improved patient care.


Assuntos
Dermatopatias Genéticas/diagnóstico , Dermatopatias Genéticas/terapia , Doenças Autoimunes do Sistema Nervoso/diagnóstico , Doenças Autoimunes do Sistema Nervoso/genética , Doenças Autoimunes do Sistema Nervoso/terapia , Síndrome do Nevo Basocelular/diagnóstico , Síndrome do Nevo Basocelular/genética , Síndrome do Nevo Basocelular/terapia , Classe I de Fosfatidilinositol 3-Quinases/antagonistas & inibidores , Dermabrasão , Fármacos Dermatológicos/uso terapêutico , Testes Genéticos , Doenças Hereditárias Autoinflamatórias/diagnóstico , Doenças Hereditárias Autoinflamatórias/genética , Doenças Hereditárias Autoinflamatórias/terapia , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Eritrodermia Ictiosiforme Congênita/diagnóstico , Eritrodermia Ictiosiforme Congênita/genética , Eritrodermia Ictiosiforme Congênita/terapia , Inibidores de Janus Quinases/uso terapêutico , Terapia a Laser , Lipoma/diagnóstico , Lipoma/genética , Lipoma/terapia , Técnicas de Diagnóstico Molecular , Mosaicismo , Anormalidades Musculoesqueléticas/diagnóstico , Anormalidades Musculoesqueléticas/genética , Anormalidades Musculoesqueléticas/terapia , Malformações do Sistema Nervoso/diagnóstico , Malformações do Sistema Nervoso/genética , Malformações do Sistema Nervoso/terapia , Nevo/diagnóstico , Nevo/genética , Nevo/terapia , Pitiríase Rubra Pilar/diagnóstico , Pitiríase Rubra Pilar/genética , Pitiríase Rubra Pilar/terapia , Inibidores de Proteínas Quinases/uso terapêutico , Síndrome de Proteu/diagnóstico , Síndrome de Proteu/genética , Síndrome de Proteu/terapia , Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores , Análise de Sequência de DNA , Dermatopatias Genéticas/genética , Protetores Solares/uso terapêutico , Serina-Treonina Quinases TOR/antagonistas & inibidores , Esclerose Tuberosa/diagnóstico , Esclerose Tuberosa/genética , Esclerose Tuberosa/terapia , Ustekinumab/uso terapêutico
4.
Dis Colon Rectum ; 62(2): 196-202, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30640835

RESUMO

BACKGROUND: Ischiorectal fossa tumors are rare. OBJECTIVE: This study reviews a single institution's series of ischiorectal tumors with comparison against presacral tumors and assesses the utility of preoperative biopsy and angioembolization. DESIGN: This is a retrospective study. SETTINGS: This study was conducted at a quaternary referral center. PATIENTS: All patients with ischiorectal tumor treated between February 1995 and April 2017 were retrospectively reviewed. Tumors extending secondarily into the ischiorectal fossa and inflammatory pathologies were excluded. INTERVENTIONS: Preoperative biopsy, neoadjuvant therapy, angioembolization, and surgical excision of these tumors were reviewed. MAIN OUTCOME MEASURES: Demographic, perioperative, pathological, and oncologic outcomes were evaluated. RESULTS: Twenty-four patients (15 female; median age 54) were identified. Two-thirds were symptomatic. Forty-six percent had a palpable mass. All patients had CT and/or MRI. Fifty percent had a preoperative biopsy, of which 83% were diagnostic, and management was altered in 50%. All patients underwent surgical excision. Fifty-five percent had local excision, 38% had radical pelvic excision, and 8% had total mesorectal excision. Two patients had preoperative angioembolization. Both had successful R0 local excision. Morbidity occurred in 25%, with 1 major complication. There was no 30-day mortality. Histopathology demonstrated 17 soft tissue tumors (3 malignant), 2 GI stromal tumors, 1 neuroendocrine tumor, 1 Merkel cell carcinoma, 1 basaloid carcinoma, 1 epidermal cyst, and 1 lipoma. R0 resection was achieved in 75%. All patients were alive after a median follow-up of 33 months. Four patients developed recurrence at a median 10 months postoperatively. All recurrences were malignant, and 75% had had a R1 resection. LIMITATIONS: This study is limited by its small numbers. The quaternary institution source may introduce bias. CONCLUSIONS: Ischiorectal fossa tumors are heterogeneous and more likely to be malignant than presacral tumors. Biopsy can be useful if a malignant diagnosis is suspected and changes management in 50% of cases. Preoperative embolization may be useful for large vascular tumors. R0 resection is important to minimize recurrence. See Video Abstract at http://links.lww.com/DCR/A779.


Assuntos
Embolização Terapêutica , Tumores do Estroma Gastrointestinal/terapia , Terapia Neoadjuvante , Neoplasias Pélvicas/terapia , Neoplasias de Tecidos Moles/terapia , Procedimentos Cirúrgicos Operatórios , Adulto , Idoso , Biópsia , Carcinoma de Célula de Merkel/diagnóstico por imagem , Carcinoma de Célula de Merkel/patologia , Carcinoma de Célula de Merkel/terapia , Procedimentos Cirúrgicos do Sistema Digestório , Cisto Epidérmico/diagnóstico por imagem , Cisto Epidérmico/patologia , Cisto Epidérmico/terapia , Feminino , Tumores do Estroma Gastrointestinal/diagnóstico por imagem , Tumores do Estroma Gastrointestinal/patologia , Humanos , Lipoma/diagnóstico por imagem , Lipoma/patologia , Lipoma/terapia , Imagem por Ressonância Magnética , Masculino , Mesentério/cirurgia , Pessoa de Meia-Idade , Tumores Neuroendócrinos/diagnóstico por imagem , Tumores Neuroendócrinos/patologia , Tumores Neuroendócrinos/terapia , Duração da Cirurgia , Diafragma da Pelve/cirurgia , Neoplasias Pélvicas/diagnóstico por imagem , Neoplasias Pélvicas/patologia , Tomografia por Emissão de Pósitrons , Cuidados Pré-Operatórios , Procedimentos Cirúrgicos Reconstrutivos , Reto/cirurgia , Estudos Retrospectivos , Neoplasias de Tecidos Moles/diagnóstico por imagem , Neoplasias de Tecidos Moles/patologia , Tomografia Computadorizada por Raios X
5.
J Cosmet Dermatol ; 18(2): 469-473, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30027646

RESUMO

BACKGROUND: Lipomas are very common benign neoplasms, which constitute 99% of all adipose-derived tumors. Main treatment option includes surgical excision, which is unacceptable for a number of patients seeking ways to improve esthetic appearance of their skin. Therefore, alternative treatment options are being sought. OBJECTIVE: The aim of the present study was to assess the efficacy of lipoma removal using a Class III CE-marked device (Aqualyx™) administered as a high-frequency ultrasound-guided injection (intralipotherapy). METHODS: A total of 17 lipomas were treated. The procedure involved a high-frequency ultrasound-guided injection. A maximum of 3 injections per a lipoma were performed. High-frequency ultrasound was used for assessing the size of lipomas and monitoring treatment-induced changes to the lipomas and adjacent tissue. RESULTS: Response to treatment was achieved in all cases. A complete removal was achieved in 70.59% of lipomas. The remaining 29.41% of lipomas were not completely removed, yet significantly reduced in size. CONCLUSION: An injection of Aqualyx™, a CE-marked drug, is a good noninvasive treatment of lipomas. Ultrasound guided procedure is recommended, as it ensures appropriate technique and enables monitoring treatment-induced changes. Considering a low number of published reports of such treatment, it is crucial to continue this research.


Assuntos
Técnicas Cosméticas/instrumentação , Galactanos/administração & dosagem , Lipoma/terapia , Neoplasias Cutâneas/terapia , Adulto , Idoso , Feminino , Humanos , Injeções Intradérmicas/métodos , Lipoma/diagnóstico por imagem , Pessoa de Meia-Idade , Resultado do Tratamento , Ultrassonografia de Intervenção
7.
Acta Dermatovenerol Alp Pannonica Adriat ; 27(3): 137-139, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30244263

RESUMO

Lipomas are the most common soft tissue tumors of mesenchymal origin. They can appear anywhere on the body, and in rare cases they may present on the hands. Lipomas represent approximately 1% to 3.8% of all benign tumors in the hands. Typically, lipomas present in the fifth or sixth decade of life, occurring in both men and women. Lipomas may appear anywhere on the hand, often presenting as painless, slow-growing, and mobile masses. Symptoms may develop if local neurovascular structures are compressed. Differential diagnosis includes liposarcoma and fibrolipomatous hamartoma. To assist with clinical diagnosis, ultrasound, computed tomography, or magnetic resonance imaging may be utilized. The best way to confirm diagnosis is with histopathology. The main treatment for hand lipomas is surgical excision. Postoperative recurrence is rare.


Assuntos
Mãos/patologia , Lipoma/diagnóstico , Lipoma/terapia , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/terapia , Progressão da Doença , Feminino , Humanos , Imagem por Ressonância Magnética , Masculino , Prognóstico , Radiografia
8.
J Vasc Surg Venous Lymphat Disord ; 6(4): 511-516, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29909856

RESUMO

OBJECTIVE: Patients with Klippel-Trénaunay syndrome (KTS) and congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and spinal/skeletal abnormalities (CLOVES) syndrome have central phlebectasia and enlarged persistent embryonic veins that are often incompetent and prone to thromboembolism. The purpose of the study was to determine the presence of phlebectasia and the incidence of symptomatic pulmonary embolism (PE). METHODS: A retrospective review was conducted of patients referred to the Vascular Anomalies Center at our institution during a 21-year period who were diagnosed with KTS and CLOVES syndrome. Of these, the patients who had PE were screened for thromboembolic risk factors in addition to phlebectasia and the presence of persistent embryonic veins. Treatment outcomes following subsequent endovascular and medical therapies were reported. RESULTS: A total of 12 KTS patients of 96 (12.5%) and 10 CLOVES syndrome patients of 110 (9%) suffered PE. Fourteen patients (64%) developed PE after surgery or sclerotherapy. All of the patients had abnormally dilated central or persistent embryonic veins; 20 patients were treated with anticoagulation (1 died at the time of presentation, and no information was available for 1) after PE, and 14 (66%) patients underwent subsequent endovascular treatment. Five patients developed recurrent PE despite anticoagulation. Two of the patients died of PE. No patients treated with endovascular closure of dilated veins had subsequent evidence of PE. CONCLUSIONS: Patients with KTS and CLOVES syndrome are at high risk for PE, particularly in the postoperative period.


Assuntos
Síndrome de Klippel-Trenaunay-Weber/epidemiologia , Lipoma/epidemiologia , Anormalidades Musculoesqueléticas/epidemiologia , Nevo/epidemiologia , Embolia Pulmonar/epidemiologia , Varizes/epidemiologia , Malformações Vasculares/epidemiologia , Veias/anormalidades , Adolescente , Adulto , Anticoagulantes/uso terapêutico , Boston/epidemiologia , Criança , Pré-Escolar , Protocolos Clínicos , Angiografia por Tomografia Computadorizada , Dilatação Patológica , Procedimentos Endovasculares/efeitos adversos , Feminino , Humanos , Incidência , Lactente , Síndrome de Klippel-Trenaunay-Weber/diagnóstico , Síndrome de Klippel-Trenaunay-Weber/terapia , Lipoma/diagnóstico , Lipoma/terapia , Masculino , Anormalidades Musculoesqueléticas/diagnóstico , Anormalidades Musculoesqueléticas/terapia , Nevo/diagnóstico , Nevo/terapia , Flebografia/métodos , Embolia Pulmonar/diagnóstico por imagem , Embolia Pulmonar/terapia , Estudos Retrospectivos , Fatores de Risco , Escleroterapia/efeitos adversos , Fatores de Tempo , Varizes/diagnóstico por imagem , Varizes/terapia , Malformações Vasculares/diagnóstico , Malformações Vasculares/terapia , Procedimentos Cirúrgicos Vasculares/efeitos adversos , Veias/diagnóstico por imagem , Adulto Jovem
9.
J Surg Oncol ; 117(8): 1786-1798, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29723405

RESUMO

Bone tumors are relatively rare in the foot and ankle region. Many of them present as cystic lesions on plain films. Due to the relative rarity of these lesions and the complex anatomy of the foot and ankle region, identification of such lesions is often delayed or they get misdiagnosed and mismanaged. This review discusses the most common cystic tumors of the foot and ankle including their radiographic features and principles of management.


Assuntos
Neoplasias Ósseas/diagnóstico , Neoplasias Ósseas/terapia , Pé/patologia , Cistos Ósseos/diagnóstico , Cistos Ósseos/terapia , Cistos Ósseos Aneurismáticos/diagnóstico , Cistos Ósseos Aneurismáticos/terapia , Condroblastoma/diagnóstico , Condroblastoma/terapia , Condroma/diagnóstico , Condroma/terapia , Fibroma/diagnóstico , Fibroma/terapia , Displasia Fibrosa Óssea/diagnóstico , Displasia Fibrosa Óssea/terapia , Pé/diagnóstico por imagem , Pé/cirurgia , Tumor de Células Gigantes do Osso/diagnóstico , Tumor de Células Gigantes do Osso/terapia , Humanos , Lipoma/diagnóstico , Lipoma/terapia , Osteoblastoma/diagnóstico , Osteoblastoma/terapia , Osteoma Osteoide/diagnóstico , Osteoma Osteoide/terapia , Sinovite Pigmentada Vilonodular/diagnóstico , Sinovite Pigmentada Vilonodular/terapia
10.
Pediatr Dermatol ; 35(3): e186-e188, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29493003

RESUMO

A patient with extensive multisystem overgrowth caused by a somatic gain of function PIK3CA-mutation is described. This case is an example of the clinical diversity of the PIK3CA-Related Overgrowth Spectrum (PROS) as the patient had overlapping features of Congenital Lipomatous Overgrowth Vascular malformations Epidermal nevi and Skeletal abnormalities (CLOVES) syndrome and Megalencephaly-Capillary malformation Polymicrogyria (MCAP) syndrome and underlines the utility of this umbrella term.


Assuntos
Anormalidades Múltiplas/diagnóstico , Classe I de Fosfatidilinositol 3-Quinases/genética , Lipoma/diagnóstico , Megalencefalia/diagnóstico , Anormalidades Musculoesqueléticas/diagnóstico , Nevo/diagnóstico , Dermatopatias Vasculares/diagnóstico , Telangiectasia/congênito , Malformações Vasculares/diagnóstico , Anormalidades Múltiplas/genética , Anormalidades Múltiplas/terapia , Sequência de Bases , Broncodilatadores/uso terapêutico , Diagnóstico Diferencial , Nutrição Enteral , Humanos , Imunossupressores/uso terapêutico , Recém-Nascido , Lipoma/genética , Lipoma/terapia , Masculino , Megalencefalia/genética , Megalencefalia/terapia , Anormalidades Musculoesqueléticas/genética , Anormalidades Musculoesqueléticas/terapia , Mutação , Nevo/genética , Nevo/terapia , Fenótipo , Respiração Artificial/métodos , Sirolimo/uso terapêutico , Dermatopatias Vasculares/genética , Dermatopatias Vasculares/terapia , Telangiectasia/diagnóstico , Telangiectasia/genética , Telangiectasia/terapia , Malformações Vasculares/genética , Malformações Vasculares/terapia
11.
Pan Afr Med J ; 31: 154, 2018.
Artigo em Francês | MEDLINE | ID: mdl-31065314

RESUMO

Lipomas localization in the parotid region is very rare. We here report a new case of a 55-year old patient, presenting with a mass in the parotid region that had progressed over the past 4 years and a literature review. A soft, mobile and painless mass was detected on palpation. The patient underwent imaging examinations (ultrasound and MRI), that enabled to retain the diagnosis of parotid lipoma. The patient decided to have conservative treatment.


Assuntos
Lipoma/diagnóstico por imagem , Imagem por Ressonância Magnética/métodos , Neoplasias Parotídeas/diagnóstico por imagem , Ultrassonografia/métodos , Tratamento Conservador/métodos , Progressão da Doença , Humanos , Lipoma/patologia , Lipoma/terapia , Masculino , Pessoa de Meia-Idade , Neoplasias Parotídeas/patologia , Neoplasias Parotídeas/terapia
12.
Neurosurg Rev ; 41(3): 737-743, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-27796602

RESUMO

The aim of this study is to compare the outcomes of surgical and conservative treatments of pediatric asymptomatic lumbosacral lipomas, and to address whether the patients can benefit from prophylactic surgeries. The literature reports of surgical and conservative treatments of child asymptomatic lumbosacral lipomas were reviewed and collected, and a meta-analysis of the reports regarding the incidence of sphincter and lower limb dysfunctions was performed. A total of five literatures were collected, containing a total of 403 patients, among which 124 patients received conservative treatments with 32 (25.81%) cases developing neurological dysfunctions during follow-up, and 279 received prophylactic surgical treatments with 30 (10.75%) patients developing neurological dysfunctions in follow-up, the difference being statistically significant (P ≤ 0.05). For pediatric asymptomatic lumbosacral lipomas of the three major subtypes, the limited source of literature so far suggests that prophylactic surgery is superior to conservative strategy in preventing the patients from neurological deterioration. Larger patient cohorts, randomized studies, and longer length of follow-ups are needed for further corroboration.


Assuntos
Tratamento Conservador/métodos , Lipoma/cirurgia , Lipoma/terapia , Região Lombossacral/cirurgia , Neoplasias da Medula Espinal/cirurgia , Adolescente , Criança , Pré-Escolar , Humanos , Lactente , Neoplasias da Medula Espinal/patologia , Resultado do Tratamento
13.
Cardiol Clin ; 35(4): 589-600, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29025549

RESUMO

Pericardial tumors are rare lesions that include a range of neoplastic conditions that may arise within the pericardium or metastasize to involve it secondarily. Understanding the spectrum of lesions that are included in the differential diagnosis of a pericardial mass-lesion is critical to making timely, accurate diagnoses and getting the appropriate therapy should one be necessary. This review summarizes the radiologic and pathologic findings of the most commonly encountered of these entities.


Assuntos
Carcinoma/diagnóstico por imagem , Neoplasias Cardíacas/diagnóstico por imagem , Hemangioma/diagnóstico por imagem , Neoplasias Pulmonares/diagnóstico por imagem , Linfoma/diagnóstico por imagem , Mesotelioma/diagnóstico por imagem , Neoplasias Embrionárias de Células Germinativas/diagnóstico por imagem , Pericárdio/diagnóstico por imagem , Sarcoma/diagnóstico por imagem , Doenças Autoimunes , Neoplasias da Mama/patologia , Carcinoma/secundário , Carcinoma/terapia , Ecocardiografia , Doença de Erdheim-Chester/diagnóstico por imagem , Doença de Erdheim-Chester/patologia , Doença de Erdheim-Chester/terapia , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/secundário , Neoplasias Cardíacas/terapia , Hemangioma/patologia , Hemangioma/terapia , Hemangiossarcoma/diagnóstico por imagem , Hemangiossarcoma/patologia , Hemangiossarcoma/terapia , Humanos , Imunoglobulina G , Lipoma/diagnóstico por imagem , Lipoma/patologia , Lipoma/terapia , Neoplasias Pulmonares/patologia , Neoplasias Pulmonares/terapia , Linfoma/patologia , Linfoma/terapia , Imagem por Ressonância Magnética , Cisto Mediastínico/diagnóstico por imagem , Cisto Mediastínico/patologia , Cisto Mediastínico/terapia , Mesotelioma/patologia , Mesotelioma/terapia , Neoplasias Embrionárias de Células Germinativas/patologia , Neoplasias Embrionárias de Células Germinativas/terapia , Paraganglioma/diagnóstico por imagem , Paraganglioma/patologia , Paraganglioma/terapia , Pericárdio/patologia , Radiografia Torácica , Sarcoma/patologia , Sarcoma/terapia , Sarcoma Sinovial/diagnóstico por imagem , Sarcoma Sinovial/patologia , Sarcoma Sinovial/terapia , Tomografia Computadorizada por Raios X
14.
Am J Surg Pathol ; 41(11): 1443-1455, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28877053

RESUMO

The classification of the until recently poorly explored group of atypical adipocytic neoplasms with spindle cell features, for which recently the term atypical spindle cell lipomatous tumor (ASLT) has been proposed, remains challenging. Recent studies have proposed ASLT as a unique entity with (in at least a significant subset of cases) a specific genetic background, namely deletions/losses of 13q14, including RB1 and its flanking genes RCBTB2, DLEU1, and ITM2B. Similar genetic aberrations have been reported in pleomorphic liposarcomas (PLSs). This prompted us to investigate a series of 21 low-grade adipocytic neoplasms with a pleomorphic lipoma-like appearance, but with atypical morphologic features (including atypical spindle cells, pleomorphic [multinucleated] cells, pleomorphic lipoblasts and poor circumscription), for which we propose the term "atypical" pleomorphic lipomatous tumor (APLT). Five cases of PLS were also included in this study. We used multiplex ligation-dependent probe amplification to evaluate genetic changes of 13q14. In addition, array-based comparative genomic hybridization was performed on 4 APLTs and all PLSs. Multiplex ligation-dependent probe amplification showed consistent loss of RB1 and its flanking gene RCBTB2 in all cases of APLT. This genetic alteration was also present in all PLSs, suggesting genetic overlap, in addition to morphologic overlap, with APLTs. However, array-based comparative genomic hybridization demonstrated more complex genetic alterations with more losses and gains in PLSs compared with APLTs. APLTs arose in the subcutis (67%) more frequently than in the deep (subfascial) soft tissues (33%). With a median follow-up of 42 months, recurrences were documented in 2 of 12 APLTs for which a long follow-up was available. Herein, we also demonstrate that APLTs share obvious overlapping morphologic, immunohistochemical, genetic and clinical characteristics with the recently defined ASLT, suggesting that they are related lesions that form a spectrum (atypical spindle cell/pleomorphic lipomatous tumor).


Assuntos
Adipócitos , Biomarcadores Tumorais , Imuno-Histoquímica , Lipoma , Técnicas de Diagnóstico Molecular , Adipócitos/química , Adipócitos/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/análise , Biomarcadores Tumorais/genética , Biópsia , Cromossomos Humanos Par 13 , Hibridização Genômica Comparativa , Europa (Continente) , Feminino , Humanos , Hibridização in Situ Fluorescente , Lipoma/química , Lipoma/genética , Lipoma/patologia , Lipoma/terapia , Masculino , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase Multiplex , Gradação de Tumores , Proteínas de Neoplasias/genética , Recidiva Local de Neoplasia , Valor Preditivo dos Testes , Proteínas de Ligação a Retinoblastoma/genética , Terminologia como Assunto , Fatores de Tempo , Resultado do Tratamento , Ubiquitina-Proteína Ligases/genética
15.
Semin Diagn Pathol ; 34(5): 453-461, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28662999

RESUMO

Breast tumors with lipomatous or liposarcomatous components are infrequently encountered, but can be a source of diagnostic difficulty if the context of the fatty differentiation is not recognized. Among the true adipocytic tumors, lipoma is the most common lipomatous tumor arising in the breast. Several mammary spindle cell tumors may show adipocytic differentiation, including fibroepithelial tumors and myofibroblastoma. Liposarcomatous components most often arise in malignant phyllodes tumors, as opposed to primary liposarcomas of the breast which are believed to be uncommon. This article will review the spectrum fat-containing tumors of the breast with an emphasis on differential diagnosis and insights from recent molecular studies.


Assuntos
Adipócitos/patologia , Angiolipoma/patologia , Neoplasias da Mama/patologia , Lipoma/patologia , Lipossarcoma/patologia , Neoplasias Fibroepiteliais/patologia , Angiolipoma/genética , Angiolipoma/terapia , Biomarcadores Tumorais/genética , Biópsia , Neoplasias da Mama/genética , Neoplasias da Mama/terapia , Diferenciação Celular , Diagnóstico Diferencial , Feminino , Predisposição Genética para Doença , Humanos , Lipoma/genética , Lipoma/terapia , Lipossarcoma/genética , Lipossarcoma/terapia , Técnicas de Diagnóstico Molecular , Neoplasias Fibroepiteliais/genética , Neoplasias Fibroepiteliais/terapia , Fenótipo , Valor Preditivo dos Testes , Prognóstico
16.
Acta Chir Belg ; 117(4): 267-269, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28636476

RESUMO

Introduction - patients: Intradural lipomas are rare congenital tumors. A case of intradural lipoma in the absence of any congenital spinal anomalies is reported. Patient presented with spinal cord compression syndrome. Methods - results - conclusions: Treatment of this disorder is still controversial.


Assuntos
Lipoma/diagnóstico por imagem , Lipoma/terapia , Neoplasias da Medula Espinal/diagnóstico por imagem , Neoplasias da Medula Espinal/terapia , Idoso , Feminino , Humanos , Imagem por Ressonância Magnética , Vértebras Torácicas
17.
Surg Clin North Am ; 97(2): 387-403, 2017 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28325193

RESUMO

Benign gastric lesions represent various pathologic entities and management considerations. Upper endoscopy serves as the primary diagnostic modality for gastric lesions. Persistent or giant gastric ulcers represent unique subtypes of ulcers, requiring investigation of the underlying cause. Medical management remains the mainstay of treatment; however, indications for surgical intervention remain. Gastric polyps also represent diverse etiologies, and accurate diagnosis requires pertinent information and tissue samples. Neoplastic lesions often present as polypoid lesions; a high index of suspicion is required when discovered endoscopically. Malignant transformation potential varies widely between the various lesions; therefore an accurate diagnosis is imperative to determine management.


Assuntos
Pólipos Intestinais/terapia , Neoplasias Gástricas/terapia , Úlcera Gástrica/terapia , Doença Crônica , Detecção Precoce de Câncer , Diagnóstico Precoce , Gastroscopia/métodos , Humanos , Pólipos Intestinais/diagnóstico , Pólipos Intestinais/etiologia , Lipoma/diagnóstico , Lipoma/etiologia , Lipoma/terapia , Recidiva , Neoplasias Gástricas/diagnóstico , Neoplasias Gástricas/etiologia , Úlcera Gástrica/diagnóstico , Úlcera Gástrica/etiologia
18.
Zhongguo Gu Shang ; 30(3): 279-281, 2017 Mar 25.
Artigo em Chinês | MEDLINE | ID: mdl-29349971

RESUMO

OBJECTIVE: To investigate the diagnostic and therapeutic procedures of intraosseous lipoma. METHODS: From June 1986 to January 2016, 19 patients with intraosseous lipoma were treated including 12 males and 7 females, aged from 24 to 76 years, a predilection aged was from 40 to 50 years in 13 cases. Symptoms presented with pain or swelling in 15 patients, the lesions were found incidentally in 3 patients, another case was bone defect lipoma replacement after curettage of bone cyst for 4 years. On plain X-ray flims of all bones showed a well-circumscribed radiolucent area. Diagnosis was established with CT or MRI. Among them, 16 cases were treated by surgical operation, 3 cases were treated by concervative treatment. All patients' clinical data, histologic findings and X-ray, CT and MRI were analysed. RESULTS: Total 19 patients were followed up from 9 to 42 months with an average of 15 months. There was no local tumor recurrence in 16 patients after excising the tumors, the remaining 3 patients showed no enlargement of the lesion. CONCLUSIONS: Surgical intervention is considered as an unnecessary in the patients diagnosied intraosseous lipoma by MRI or CT. Patients with symptomatic should adopt surgical treatment with curettage and bone grafting.


Assuntos
Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Ósseas/terapia , Lipoma/diagnóstico por imagem , Lipoma/terapia , Adulto , Idoso , Neoplasias Ósseas/cirurgia , Tratamento Conservador/estatística & dados numéricos , Curetagem/estatística & dados numéricos , Feminino , Humanos , Lipoma/cirurgia , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Tomografia Computadorizada por Raios X
19.
Oncotarget ; 8(4): 6896-6913, 2017 Jan 24.
Artigo em Inglês | MEDLINE | ID: mdl-28036291

RESUMO

Liposarcoma (LPS) is a malignancy with extreme heterogeneity and thus optimization towards personalizing patient prognosis and treatment is essential. Here, we evaluated miR-155, miR-21, miR-143, miR-145 and miR-451 that are implicated in LPS, as novel FFPE tissue biomarkers.A total of 83 FFPE tissue specimens from primary LPS and lipomas (LPM) were analyzed. A proteinase K incubation-Trizol treatment coupled protocol was used for RNA isolation. After polyadenylation of total RNA and reverse transcription, expression analysis of 9 candidate reference and 5 target miRNAs was performed by qPCR. Genorm and NormFinder were used for finding the most suitable molecules for normalization. Survival analyses were performed in order to evaluate the prognostic potential of miRNAs.MiR-103 and miR-191 are most suitable for normalization of miRNA expression in LPS. MiR-155 and miR-21 are clearly overexpressed (P<0.001) in LPS compared with LPM specimens, whereas miR-145 (P<0.001), miR-143 (P =0.008) and miR-451 (P=0.037) are underexpressed. MiR-155 (P=0.007) and miR-21 (P=0.029) are differentially expressed between well-differentiated, dedifferentiated, myxoid/round cell and pleomorphic LPs tumor subtypes. MiR-155 represents a novel independent indicator of unfavorable prognosis in LPS (HR = 2.97, 95% CI = 1.23-7.17, P = 0.016).


Assuntos
Biomarcadores Tumorais/genética , Fixadores/química , Formaldeído/química , Lipoma/genética , Lipossarcoma/genética , MicroRNAs/genética , Inclusão em Parafina , Fixação de Tecidos/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Área Sob a Curva , Progressão da Doença , Intervalo Livre de Doença , Feminino , Regulação Neoplásica da Expressão Gênica , Humanos , Estimativa de Kaplan-Meier , Lipoma/mortalidade , Lipoma/patologia , Lipoma/terapia , Lipossarcoma/mortalidade , Lipossarcoma/patologia , Lipossarcoma/terapia , Masculino , Pessoa de Meia-Idade , Gradação de Tumores , Valor Preditivo dos Testes , Modelos de Riscos Proporcionais , Curva ROC , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Fatores de Tempo , Resultado do Tratamento , Regulação para Cima , Adulto Jovem
20.
J Clin Neurosci ; 34: 232-234, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27729180

RESUMO

CLOVES (congenital lipomatous overgrowth, vascular malformations, epidermal nevi, and scoliosis/skeletal/spinal anomalies) syndrome is a congenital and almost exclusively pediatric syndrome associated with vascular malformations of the neuroaxis. We report the case of a complex spinal arteriovenous fistula in an adult woman with CLOVES syndrome treated using a multidisciplinary approach with endovascular embolization and microsurgical technique, and review the medical literature on this disease.


Assuntos
Embolização Terapêutica/métodos , Lipoma/diagnóstico por imagem , Lipoma/terapia , Microcirurgia/métodos , Anormalidades Musculoesqueléticas/diagnóstico por imagem , Anormalidades Musculoesqueléticas/terapia , Nevo/diagnóstico por imagem , Nevo/terapia , Malformações Vasculares/diagnóstico por imagem , Malformações Vasculares/terapia , Feminino , Humanos , Lipoma/cirurgia , Pessoa de Meia-Idade , Anormalidades Musculoesqueléticas/cirurgia , Nevo/cirurgia , Malformações Vasculares/cirurgia
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