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1.
BMJ Case Rep ; 14(1)2021 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-33431536

RESUMO

Changes of the hepatic subcapsular blood flow with the early appearance of hypervascularity near the falciform ligament are rare radiologic findings. They present most frequently in cases of superior vena cava (SVC) obstruction and are related to the recruitment of the cavo-mammary-phrenic-hepatic-capsule-portal and the cavo-superficial-umbilical-portal pathways. We present the case of a 52-year-old female patient with an highly aggressive retroperitoneal liposarcoma with SVC obstruction caused by external compression due to a mediastinal metastatic mass. The patient exhibited no symptoms of SVC obstruction due to the collateral cavo-portal pathways.


Assuntos
Dor Abdominal/etiologia , Lipossarcoma/diagnóstico , Neoplasias do Mediastino/diagnóstico , Cuidados Paliativos/legislação & jurisprudência , Neoplasias Retroperitoneais/diagnóstico , Síndrome da Veia Cava Superior/diagnóstico , Dor Abdominal/diagnóstico , Antibióticos Antineoplásicos/uso terapêutico , Doxorrubicina/uso terapêutico , Evolução Fatal , Feminino , Humanos , Biópsia Guiada por Imagem , Lipossarcoma/complicações , Lipossarcoma/patologia , Lipossarcoma/terapia , Neoplasias do Mediastino/complicações , Neoplasias do Mediastino/secundário , Neoplasias do Mediastino/terapia , Pessoa de Meia-Idade , Invasividade Neoplásica , Neoplasias Retroperitoneais/complicações , Neoplasias Retroperitoneais/patologia , Neoplasias Retroperitoneais/terapia , Síndrome da Veia Cava Superior/etiologia , Síndrome da Veia Cava Superior/terapia , Tomografia Computadorizada por Raios X , Veia Cava Superior/diagnóstico por imagem
2.
Am Surg ; 86(9): 1208-1211, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32683914

RESUMO

Atypical spindle cell lipomatous neoplasm, also known as well-differentiated spindle cell liposarcoma, represents a newly discovered entity of adipocytic tumors. Recent research has shown this tumor variant to be more related to spindle cell lipoma, rather than the originally hypothesized atypical lipomatous tumor spectrum. Here we present a case of a 58-year-old man with a history of chronic lymphocytic leukemia with an enlarging mass on the posterior left shoulder, initially hypothesized to be a benign lipoma. However, magnetic resonance imaging showed a large, multiseptated, heterogeneous mass concerning for soft tissue sarcoma. After resection, pathologic analysis showed cells closely resembling spindle cell lipoma, with additional cellular and fascicular zones containing lipoblasts and mitotic figures. Molecular analysis showed no MDM2 amplification. This lack of amplification indicates this tumor is distinctly different from an atypical lipomatous tumor, which characteristically displays MDM2 amplification. However, tumor expression of RB1 was normal. The majority of atypical spindle cell lipomatous neoplasms are associated with RB1 deletions. We conclude that we have a unique example of an atypical spindle cell lipomatous tumor.


Assuntos
Procedimentos Cirúrgicos Dermatológicos/métodos , Leucemia Linfocítica Crônica de Células B/complicações , Lipossarcoma/cirurgia , Neoplasias Cutâneas/cirurgia , Biópsia , Diagnóstico Diferencial , Humanos , Leucemia Linfocítica Crônica de Células B/diagnóstico , Lipossarcoma/diagnóstico , Masculino , Pessoa de Meia-Idade , Neoplasias Cutâneas/diagnóstico
3.
Dig Dis Sci ; 65(6): 1643-1651, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32300935

RESUMO

Dedifferentiated liposarcomas are rare; localization of these tumors in the descending colon is extremely uncommon. We describe the case of a 75-year-old man with a dedifferentiated liposarcoma originating from the descending colon that manifested as partial bowel obstruction. The very uncommon presentation of this rare disease contributed to a challenging diagnostic process. The patient was successfully treated by surgical resection of the mass through left hemicolectomy. Although exceptionally unusual, soft tissue sarcomas should be considered in the differential diagnosis for bowel obstruction. Currently, radical resection of the mass is considered to be the first-line treatment.


Assuntos
Neoplasias do Colo/diagnóstico , Lipossarcoma/diagnóstico , Idoso , Neoplasias do Colo/patologia , Neoplasias do Colo/cirurgia , Humanos , Lipossarcoma/patologia , Lipossarcoma/cirurgia , Masculino
5.
Biomed Res Int ; 2020: 9765162, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32185230

RESUMO

Purpose: Technetium-99m diethylene triamine pentaacetic acid (Tc-99m DTPA) renal dynamic scintigraphy is a widely used imaging technique that evaluates renal function of patients with extrarenal abnormalities, but its clinical value in potentially offering us information on proliferation of liposarcoma has not yet been reported. Methods: We retrospectively reviewed 7 patients with histopathologically confirmed retroperitoneal liposarcoma who underwent Tc-99m DTPA renal dynamic scintigraphy. The clinical data, histopathological findings, Glomerular Filtration Rate (GFR), and Tc-99m DTPA uptake were recorded. Results: Dedifferentiated liposarcoma and well-differentiated liposarcoma showed dissimilar degrees of Tc-99m DTPA uptake, an observation that correlated with Ki-67 expression (p < 0.01). 4 of the 7 patients were diagnosed with dedifferentiated liposarcoma, showing a moderate uptake of Tc-99m DTPA and greater than 20% Ki-67 expression on histological slides. Meanwhile, the remaining 3 patients, diagnosed with well-differentiated liposarcoma, showed no uptake of Tc-99m DTPA and Ki-67 expression of less than 5%. Conclusions: This study suggests that Tc-99m DTPA renal dynamic scintigraphy provides diagnostic value in patients with retroperitoneal liposarcoma, not only in evaluating renal function but also in visualizing lesion-related radionuclide uptake, which may potentially offer further clinical insights into tumor proliferation and provide prognostic value for clinical outcomes in patients with retroperitoneal liposarcoma.


Assuntos
Lipossarcoma/diagnóstico por imagem , Lipossarcoma/diagnóstico , Neoplasias Retroperitoneais/diagnóstico por imagem , Neoplasias Retroperitoneais/diagnóstico , Pentetato de Tecnécio Tc 99m/administração & dosagem , Idoso , Proliferação de Células/fisiologia , Feminino , Taxa de Filtração Glomerular/fisiologia , Humanos , Rim/diagnóstico por imagem , Rim/fisiopatologia , Testes de Função Renal/métodos , Lipossarcoma/fisiopatologia , Masculino , Pessoa de Meia-Idade , Prognóstico , Cintilografia/métodos , Compostos Radiofarmacêuticos/administração & dosagem , Neoplasias Retroperitoneais/fisiopatologia , Estudos Retrospectivos , Tomografia Computadorizada de Emissão/métodos
6.
Autops. Case Rep ; 10(1): 2020137, Jan.-Mar. 2020. ilus
Artigo em Inglês | LILACS | ID: biblio-1087663

RESUMO

Actinomycosis is an uncommon, endogenous, and chronic infection with varied and nonspecific clinical features such as abdominal, pelvic or cervical masses, ulcerative lesions, abscesses, draining fistula, fibrosis, and constitutional symptoms. The disease ensues when the bacteria disrupt the mucosal barrier, invade, and spread throughout interfascial planes. Currently, the diagnosis of actinomycosis is challenging because of its very low frequency and depending on the clinical presentation it may masquerade malignancies. Therapy consists initially in intravenous penicillin, followed by an oral regimen that may be extended until a year of treatment. A timely diagnosis is crucial to avoid extensive therapeutic attempt as surgery. However, a biopsy or drainage of abscesses and fistula's tract may be required not only as a diagnostic procedure as part of the therapy. We report the case of a 72-year-old woman with an abdominal mass initially misdiagnosed as a liposarcoma. A second biopsy of a skin lesion of the abdominal wall made the diagnosis of actinomycosis, avoiding a major surgical procedure. The patient was treated with a long-term course of antibiotics with favorable outcome. Liposarcoma was ruled out after the patient's full recovery with antibiotics and the misdiagnosis was credit to the overconfidence on the immunohistochemical positivity to MDM2.


Assuntos
Humanos , Feminino , Idoso , Actinomicose/diagnóstico , Abdome/anormalidades , Lipossarcoma/diagnóstico , Diagnóstico Diferencial
7.
Medicine (Baltimore) ; 99(6): e18985, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32028409

RESUMO

RATIONALE: Oral liposarcoma is an extremely rare lesion that is often clinically misdiagnosed as a benign lesion because of its asymptomatic and indolent clinical course. we report a case of atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) of buccal mucosa, provisionally diagnosed as lipoma. PATIENT CONCERNS: A 97-year-old female was referred to dentistry and oral surgery department with an asymptomatic mass on the right buccal mucosa which had been present for an unknown period of time. DIAGNOSIS: Magnetic resonance imaging demonstrated a well-circumscribed lesion at the right buccal mucosa, and a lipoma was suspected. INTERVENTIONS: Surgical removal was performed, and a diagnosis of ALT/WDL was made. She and her family refused additional treatment due to her age. OUTCOMES: At the 10 months follow-up, the patient remained free of disease. LESSONS: The indolent clinical course and small size of oral liposarcoma can lead to provisional clinical diagnosis of benign lesion.


Assuntos
Lipossarcoma/diagnóstico , Neoplasias Bucais/diagnóstico , Idoso de 80 Anos ou mais , Feminino , Humanos , Lipoma/diagnóstico , Lipossarcoma/patologia , Lipossarcoma/cirurgia , Imagem por Ressonância Magnética , Neoplasias Bucais/patologia , Neoplasias Bucais/cirurgia
8.
G Chir ; 41(1): 18-33, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32038009

RESUMO

BACKGROUND: Retroperitoneal sarcoma is a rare malignancy arising from mesenchymal cells, most commonly presented as an abdominal mass and is associated with poor prognosis. The most effective treatment modality for retroperitoneal sarcomas is complete surgical resection, including sometimes adjacent organs infiltrated by the tumor. Radiotherapy is frequently applied and has shown some benefit, while the role of chemotherapy and molecular-targeted agents is still not clear. Local recurrence is common for retroperitoneal sarcomas and still remains the main cause of death. The major factors associated with the overall survival are tumor grade, histological subtype, complete macroscopic excision and multifocality. AIM: To report our experience via the presentation of patients with retroperitoneal sarcomas managed in our department during the period 2014-18; and to review the current literature. PATIENTS AND METHODS: Eight patients appeared with chronic non-specific complaints including abdominal distension and changes in bowel or bladder habit, while one patient presented with acute abdominal pain due to mass rupture. All of the patients underwent surgical resection of the tumor. RESULTS: Among the patients, seven were operated for primary disease and one only for recurrent. The most common histologic type was liposarcoma (well-differentiated, dedifferentiated), found in five patients; followed by leiomyosarcoma found in two cases. Fibrous histiocytoma was found in only one case. The masses were removed with macroscopically clear margins (R0 and R1 resections) in four cases. In five patient cases adjuvant therapy was required. Three patients are still alive and free of disease. CONCLUSIONS: Retroperitoneal sarcomas present to be a therapeutic challenge based on their location, their extent at the time of diagnosis and the high risk of local recurrence or distant metastasis. Their management requires a multidisciplinary approach, with the surgical resection remaining the mainstay of curative treatment, combined with surveillance for early detection of recurrence or metastases.


Assuntos
Neoplasias Retroperitoneais/diagnóstico , Neoplasias Retroperitoneais/cirurgia , Sarcoma/diagnóstico , Sarcoma/cirurgia , Dor Abdominal/etiologia , Dor Aguda/etiologia , Histiocitoma Fibroso Benigno/complicações , Histiocitoma Fibroso Benigno/diagnóstico , Histiocitoma Fibroso Benigno/cirurgia , Humanos , Leiomiossarcoma/complicações , Leiomiossarcoma/diagnóstico , Leiomiossarcoma/cirurgia , Lipossarcoma/complicações , Lipossarcoma/diagnóstico , Lipossarcoma/cirurgia , Recidiva Local de Neoplasia/diagnóstico , Recidiva Local de Neoplasia/cirurgia , Doenças Raras/complicações , Doenças Raras/diagnóstico , Doenças Raras/cirurgia , Neoplasias Retroperitoneais/complicações , Sarcoma/complicações
9.
Future Oncol ; 16(1s): 33-38, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31975628

RESUMO

We report the case of a heavily pretreated male subject affected by left funiculus liposarcoma and successfully treated with eribulin mesylate. After three surgical interventions, radiotherapy on the lesion of the penile bulb for satellite nodules and an epirubicin + ifosfamide chemotherapy treatment for six cycles, eribulin was administered at the dose of 1.1 mg/m2 on days 1 and 8, every 3 weeks for a total of nine cycles. A significant reduction of the lesions was achieved after four cycles of therapy, with a good profile of tolerability.


Assuntos
Antineoplásicos/uso terapêutico , Furanos/uso terapêutico , Neoplasias dos Genitais Masculinos/tratamento farmacológico , Cetonas/uso terapêutico , Lipossarcoma/tratamento farmacológico , Cordão Espermático/patologia , Antineoplásicos/administração & dosagem , Antineoplásicos/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Furanos/administração & dosagem , Furanos/efeitos adversos , Neoplasias dos Genitais Masculinos/diagnóstico , Humanos , Cetonas/administração & dosagem , Cetonas/efeitos adversos , Lipossarcoma/diagnóstico , Masculino , Retratamento , Tomografia Computadorizada por Raios X , Resultado do Tratamento
10.
Int J Surg Pathol ; 28(3): 336-340, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31672072

RESUMO

Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) and spindle cell lipoma are lipomatous tumors with distinct clinical, molecular, and prognostic features. Although histological and immunophenotypic features can overlap between ALT/WDL and spindle cell lipoma, the oncogenesis and clinical behavior are markedly different. In borderline cases, molecular analysis for MDM2 or CDK4 amplification can aid in distinguishing ALT/WDL from spindle cell lipoma. Although dedifferentiated liposarcoma has been reported to harbor both MDM2 amplification and loss of the RB1 region, we are not aware of a reported RB1 loss in well-differentiated ALT/WDL. In this article, we present a 69-year-old woman with a lipomatous tumor in the gluteal region that histologically, immunohistochemically, and molecularly mimicked spindle cell lipoma (with positive immunohistochemical staining for CD34 and loss of the RB1 gene region), yet harbored amplification of MDM2 and CDK4 confirmed by fluorescence in situ hybridization, supporting classification as ALT/WDL. This case strengthens the argument that in atypical clinical contexts, molecular studies for MDM2/CDK4 should be considered in tumors resembling spindle cell lipoma.


Assuntos
Biomarcadores Tumorais/análise , Lipoma/diagnóstico , Lipossarcoma/diagnóstico , Lipossarcoma/patologia , Neoplasias de Tecidos Moles/patologia , Idoso , Biomarcadores Tumorais/genética , Quinase 4 Dependente de Ciclina/genética , Diagnóstico Diferencial , Feminino , Amplificação de Genes , Humanos , Lipoma/genética , Lipoma/patologia , Lipossarcoma/genética , Proteínas Proto-Oncogênicas c-mdm2/genética , Proteínas de Ligação a Retinoblastoma/genética , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/genética , Ubiquitina-Proteína Ligases/genética
11.
J Surg Res ; 247: 103-107, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31767281

RESUMO

BACKGROUND: Lipomatous masses are the most common soft tissue tumors. While the majority are benign lipomas, it is important to identify those masses that are malignant prior to excision. Current guidelines recommend core needle biopsy (CNB) for all lipomatous masses larger than 3-5 cm. The objective of this study was to determine if routine preoperative CNB based on mass size is necessary, or if radiographic features can guide the need for CNB. MATERIALS AND METHODS: Patients who underwent excision of extremity or truncal lipomatous masses at a single institution from October 2014 to July 2017 were retrospectively reviewed. By protocol, preoperative imaging was routinely obtained for all masses larger than 5 cm. High-risk radiographic features (intramuscular location, septations, nonfat nodules, heterogeneity, and ill-defined margins) and surgical pathology were evaluated to determine patients most likely to benefit from preoperative CNB. RESULTS: Of 178 patients, 2 (1.1%) had malignant tumors on surgical pathology. All masses smaller than 5 cm were benign and, if imaging was obtained, had two or fewer high-risk radiographic features. Both of the patients with malignant tumors had masses larger than 5 cm, preoperative imaging that showed at least four high-risk radiographic features, and underwent CNB prior to excision. CONCLUSIONS: The overall rate of malignancy is very low. The results of this study suggest that lipomatous masses smaller than 5 cm without concerning clinical characteristics do not require preoperative imaging or CNB. Conversely, lipomatous masses larger than 5 cm should undergo routine MRI with subsequent CNB if multiple high-risk radiographic features are present.


Assuntos
Lipoma/diagnóstico , Lipossarcoma/diagnóstico , Cuidados Pré-Operatórios/normas , Neoplasias de Tecidos Moles/diagnóstico , Adulto , Biópsia com Agulha de Grande Calibre/normas , Biópsia com Agulha de Grande Calibre/estatística & dados numéricos , Diagnóstico Diferencial , Feminino , Humanos , Lipoma/patologia , Lipoma/cirurgia , Lipossarcoma/cirurgia , Imagem por Ressonância Magnética/normas , Imagem por Ressonância Magnética/estatística & dados numéricos , Masculino , Pessoa de Meia-Idade , Guias de Prática Clínica como Assunto , Cuidados Pré-Operatórios/métodos , Estudos Retrospectivos , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/cirurgia , Carga Tumoral
12.
Virchows Arch ; 476(5): 783-786, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-31732813

RESUMO

Sarcomatoid renal cell carcinoma is a highly aggressive form of carcinoma, histologically showing both carcinomatous and mesenchymal component in different proportions. We present a case of advanced type 1 papillary sarcomatoid renal cell carcinoma infiltrating adjacent organs and showing positivity for MDM2 by immunohistochemistry and MDM2 amplification by fluorescence in situ hybridization. This finding, together with sarcomatoid morphology, poses a potential pitfall for diagnosis with dedifferentiated liposarcoma. MDM2 is known to be altered in various human sarcomas. Only recently, MDM2 alterations have been reported in carcinomas. The presented case illustrates the need of thorough sampling with clinic-pathological correlation before making a final diagnosis in sarcomatoid retroperitoneal tumours. Additionally, the potential clinical implications of MDM2 amplification in renal cell carcinoma are discussed.


Assuntos
Carcinoma de Células Renais/diagnóstico , Lipossarcoma/diagnóstico , Proteínas Proto-Oncogênicas c-mdm2/genética , Neoplasias Retroperitoneais/diagnóstico , Sarcoma/diagnóstico , Idoso , Carcinoma de Células Renais/genética , Carcinoma de Células Renais/patologia , Humanos , Imuno-Histoquímica , Lipossarcoma/genética , Lipossarcoma/patologia , Masculino , Proteínas Proto-Oncogênicas c-mdm2/metabolismo , Neoplasias Retroperitoneais/genética , Neoplasias Retroperitoneais/patologia , Sarcoma/genética , Sarcoma/patologia
13.
Future Oncol ; 16(1s): 25-32, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31858818

RESUMO

Systemic treatments for advanced soft tissue sarcoma are limited. Eribulin showed activity in metastatic soft tissue sarcoma, particularly liposarcomas. Data from six patients with advanced liposarcoma that received eribulin as third- or fourth-line therapy are presented herein. Eribulin treatment was well tolerated; no grade 3-4 toxicity or therapy delay was observed. Two patients had a partial response; four had a prolonged stable disease. The first case, with pre-existing chronic renal dysfunction, achieved a 6-month stable disease with dose-reduced eribulin. The second case became resectable after eribulin treatment, with a 6-month complete surgical remission. The third case obtained a 7-month stable disease with eribulin and stereotactic body radiotherapy. The last three cases were ≥65 years old, and two of them had objective response with eribulin.


Assuntos
Antineoplásicos/uso terapêutico , Furanos/uso terapêutico , Cetonas/uso terapêutico , Lipossarcoma/diagnóstico , Lipossarcoma/tratamento farmacológico , Idoso , Antineoplásicos/administração & dosagem , Antineoplásicos/efeitos adversos , Biomarcadores , Feminino , Furanos/administração & dosagem , Furanos/efeitos adversos , Humanos , Cetonas/administração & dosagem , Cetonas/efeitos adversos , Lipossarcoma/complicações , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Estadiamento de Neoplasias , Insuficiência Renal Crônica/complicações , Insuficiência Renal Crônica/diagnóstico , Retratamento , Tomografia Computadorizada por Raios X , Resultado do Tratamento
15.
J Card Surg ; 35(2): 495-498, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31803967

RESUMO

Dedifferentiated liposarcoma (DDLPS) is a rare type of neoplasm which can originally rise in cardiac chamber. Owing to the recurrence and distant metastasis, the prognosis of the primary malignant cardiac tumor is extremely poor and remains a challenge for cardiac surgeons. Here, we report a patient with an intracavitary mass which was diagnosed as DDLPS by postoperative pathological examinations, experienced repeated in-situ recurrence of the malignant cardiac tumor.


Assuntos
Neoplasias Cardíacas/patologia , Lipossarcoma/patologia , Recidiva Local de Neoplasia/patologia , Procedimentos Cirúrgicos Cardíacos , Ecocardiografia , Feminino , Neoplasias Cardíacas/diagnóstico , Humanos , Lipossarcoma/diagnóstico , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/diagnóstico , Tomografia Computadorizada por Raios X
16.
Internist (Berl) ; 61(2): 217-222, 2020 Feb.
Artigo em Alemão | MEDLINE | ID: mdl-31712872

RESUMO

In this article, the authors present the case of a 66-year-old man who was diagnosed with the first recurrence of his retroperitoneal liposarcoma 7 years after initial diagnosis. In the following 10 years, he needed a total of eight operations, chemotherapy, and radiotherapy because of another seven recurrences. This is the first report on a patient with eight recurrences of a retroperitoneal liposarcoma being in a relatively good general condition even 17 years after initial diagnosis.


Assuntos
Lipossarcoma , Neoplasias Retroperitoneais , Idoso , Humanos , Lipossarcoma/diagnóstico , Lipossarcoma/cirurgia , Masculino , Recidiva Local de Neoplasia , Neoplasias Retroperitoneais/diagnóstico , Neoplasias Retroperitoneais/cirurgia
17.
Future Oncol ; 16(1s): 5-8, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31872769

RESUMO

Retroperitoneal sarcomas are extremely rare malignant tumors. The most common type of sarcomas arising in the retroperitoneum are liposarcomas, occurring mostly in the sixth and seventh decades of life. The only potentially curative approach to liposarcomas is the complete surgical resection of the tumor with negative microscopic margins. However, retroperitoneal liposarcomas exhibit a propensity for local recurrence and distant metastasis despite the negative surgical margins, thus requiring additional therapy. Eribulin demonstrated a benefit in terms of overall survival in patients with advanced or metastatic liposarcoma. We report two cases of patients, both submitted to concomitant right nephrectomy, who experienced a long-lasting control of recurrent retroperitoneal liposarcoma before being submitted to eribulin-based therapeutic regimens (23 and 24 treatment cycles completed, respectively).


Assuntos
Antineoplásicos/uso terapêutico , Furanos/uso terapêutico , Cetonas/uso terapêutico , Lipossarcoma/complicações , Lipossarcoma/tratamento farmacológico , Neoplasias Retroperitoneais/complicações , Neoplasias Retroperitoneais/tratamento farmacológico , Rim Único/complicações , Idoso , Idoso de 80 Anos ou mais , Antineoplásicos/administração & dosagem , Antineoplásicos/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Duração da Terapia , Furanos/administração & dosagem , Furanos/efeitos adversos , Humanos , Cetonas/administração & dosagem , Cetonas/efeitos adversos , Lipossarcoma/diagnóstico , Imagem por Ressonância Magnética , Masculino , Nefrectomia , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Neoplasias Retroperitoneais/diagnóstico , Tomografia Computadorizada por Raios X , Resultado do Tratamento
18.
Future Oncol ; 16(1s): 21-24, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31872768

RESUMO

We describe the case of a male subject affected by retroperitoneal advanced, anthracycline-pretreated liposarcoma, who experienced a long, beneficial clinical effect from eribulin treatment. In March 2013, a left, paraortic, retroperitoneal mass was surgically removed and diagnosed as Mdm2-positive dedifferentiated liposarcoma. In June 2015, a CT scan revealed disease progression and first-line epirubicin/ifosfamide treatment was started, followed by epirubicin in monotherapy. In January 2017, following a new disease progression, the patient started a second-line eribulin treatment that went on for about 1 year with no major adverse events. The CT scans performed every 3-4 months showed stable disease. After 13 months of treatment, a CT scan revealed disease progression and 10 days later, the patient died of bowel perforation and peritonitis.


Assuntos
Antineoplásicos/uso terapêutico , Furanos/uso terapêutico , Cetonas/uso terapêutico , Lipossarcoma/diagnóstico , Lipossarcoma/tratamento farmacológico , Antineoplásicos/administração & dosagem , Antineoplásicos/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Progressão da Doença , Evolução Fatal , Furanos/administração & dosagem , Furanos/efeitos adversos , Humanos , Cetonas/administração & dosagem , Cetonas/efeitos adversos , Masculino , Retratamento , Tomografia Computadorizada por Raios X , Resultado do Tratamento
19.
Pan Afr Med J ; 33: 282, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31692859

RESUMO

Paratesticular liposarcomas (PLS) is a very uncommon pathology type of paratesticular sarcomas, with less 200 similar cases reported to date in the English literature. There are a few cases regarding giant paratesticular liposarcoma measuring over 10 cm. We present an unusual case with a giant well differentiated PLS of the left testis extended to the pelvic cavity. We report the case of a 55-year-old man who presented with large left groin mass. The patient underwent left orchiectomy following a cure of a scrotal hernia. Histological and immunohistochemical findings were suggestive of a well-differentiated liposarcoma of spermatic cord. The surgical margins were positive. Metastatic work-up, which included CT of the thorax, abdomen and pelvis, did not reveal any distant metastasis in thorax but there is a left pathological external iliac lymph nodes and a left lateroplevic lipomatous mass extended to the iliac fossa and left parietocolic gutter up to the umbilicus measuring 15x7x17 cm. Our patient refused treatment. A review of the literature revealed that there are fewer cases of giant well differentiated paratesticular liposarcoma extended to the pelvic cavity were reported. This study focuses on the clinical characteristics and treatment of this rare type of tumours.


Assuntos
Neoplasias dos Genitais Masculinos/diagnóstico , Lipossarcoma/diagnóstico , Cordão Espermático/patologia , Neoplasias Testiculares/diagnóstico , Neoplasias dos Genitais Masculinos/patologia , Neoplasias dos Genitais Masculinos/cirurgia , Humanos , Lipossarcoma/patologia , Lipossarcoma/cirurgia , Masculino , Margens de Excisão , Pessoa de Meia-Idade , Orquiectomia , Neoplasias Testiculares/patologia , Neoplasias Testiculares/cirurgia
20.
Hinyokika Kiyo ; 65(9): 389-392, 2019 Sep.
Artigo em Japonês | MEDLINE | ID: mdl-31697883

RESUMO

A 53-year-old man visited a doctor due to left inguinal enlargement. He was diagnosed with left inguinal hernia with omentum as the content by a computed tomography (CT)scan. He underwent open inguinal hernia repair ; however, an inguinal tumor was diagnosed intraoperatively and was resected as much as possible. Although the tumor resection was macroscopically incomplete, he was followed up without any treatment because the tumor was histologically diagnosed as lipoma. Sixteen months after surgery, a 15 cm inguinal mass and a 7 cm left intrascrotal mass were detected by follow-up CT, and he was referred to our hospital. He underwent open surgery for wide excision of the tumor with a diagnosis of spermatic cord liposarcoma and left hydrocele of testis. The spermatic cord tumor was histologically diagnosed as well differentiated liposarcoma. He has been alive without recurrence for more than 10 months after surgery. It is sometimes difficult to distinguish a spermatic cord liposarcoma from inguinal hernia by imaging examinations.


Assuntos
Neoplasias dos Genitais Masculinos , Hérnia Inguinal , Lipossarcoma , Cordão Espermático , Hidrocele Testicular , Diagnóstico Diferencial , Neoplasias dos Genitais Masculinos/diagnóstico , Hérnia Inguinal/diagnóstico , Humanos , Lipossarcoma/diagnóstico , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada por Raios X
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