Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 4.975
Filtrar
2.
Hautarzt ; 72(1): 2-5, 2021 Jan.
Artigo em Alemão | MEDLINE | ID: mdl-33346860

RESUMO

Skin aging results from the interaction of genetic and nongenetic so-called exposomal, factors. Among the exposomal factors, chronic, life-long exposure to sunlight is of eminent importance for the development of skin aging characteristics. Importantly, photoaging of human skin is not only caused by ultraviolet (UV) B and A radiation, but is also the consequence of exposure to wavelengths beyond the UV spectrum. These include visible, i.e. blue light (400-440 nm) as well as the short part of infrared radiation, i.e. IRA (760-1200 nm). Here we summarize the scientific evidence supporting these conclusions and emphasize the resulting consequences for daily photoprotection of human skin. We also explain the clinical significance of the concept that is offered by the skin aging exposome, which e.g. takes into account the fact that sunlight interacts with other exposomal factors and that this interaction is important for photoaging of the skin.


Assuntos
Envelhecimento da Pele , Humanos , Pele , Luz Solar/efeitos adversos , Protetores Solares/uso terapêutico , Raios Ultravioleta/efeitos adversos
3.
Medicine (Baltimore) ; 99(45): e23105, 2020 Nov 06.
Artigo em Inglês | MEDLINE | ID: mdl-33157985

RESUMO

The relationship between solar ultraviolet radiation and the risk of breast cancer is conflicting. The purpose of our study was to quantitatively assess the relationship between solar ultraviolet radiation and breast cancer risk and to analyze related factors such as age and sunscreen use.Articles indexed in PubMed and Embase and published between January 2005 and March 2020 were searched for relevant keywords. The relative risk was calculated using random-effect or fixed-effect models in the meta-analysis and dose-response meta-analysis, which were conducted according to the Meta-Analyses of Observational Studies in Epidemiology reporting guidelines. Sensitivity analyses for heterogeneity and publication bias were evaluated.Six studies were eligible for inclusion in the meta-analysis, and three of these were included in the dose-response analysis. We found a correlation between exposure to solar ultraviolet radiation and breast cancer risk (relative risk: 0.70, 95% confidence interval: 0.65, 0.75). We also found a linear dose-response relationship between the exposure and breast cancer risk (relative risk: 0.86, 95% confidence interval: 0.81, 0.91) in women over 40. Not tanning and covering the limbs were associated with breast cancer risk, but sunscreen use was not.Exposure to solar ultraviolet radiation is negatively correlated with breast cancer risk, and the association is linear in women over 40. This is the first dose-response meta-analysis on the topic, and the influence of factors such as estrogen receptor status, occupational exposure, and ethnicity requires in-depth study.


Assuntos
Neoplasias da Mama/epidemiologia , Neoplasias da Mama/etiologia , Neoplasias Induzidas por Radiação/epidemiologia , Neoplasias Induzidas por Radiação/etiologia , Exposição à Radiação/efeitos adversos , Luz Solar/efeitos adversos , Raios Ultravioleta/efeitos adversos , Relação Dose-Resposta à Radiação , Feminino , Humanos , Medição de Risco
4.
J Oleo Sci ; 69(9): 1117-1124, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32879199

RESUMO

4-tert-Butyl-4'-methoxydibenzoylmethane (BMDM) is widely used throughout the world as a highly effective UVA absorber that can prevent the progression of photoaging in skin. However, due to its low photostability, BMDM is also known for the disadvantage of having a reduced capability to absorb UVA during prolonged exposure to sunlight. Although many studies have been carried out to overcome this disadvantage of BMDM, little attention has been paid to how the radicals generated from BMDM during UV exposure influence the skin. Therefore, the purpose of this study was twofold: One goal was to clarify the influence of radicals on human skin using cytotoxicity as a parameter. The second was to propose a solution that could reduce the radical formation while taking photostability into consideration. Using ESR spin trapping and superoxide dismutase (SOD) treatment, the radicals produced by the UV exposure of BMDM were shown to be superoxide anion radicals (•O2-). HaCaT keratinocytes exposed to UVA in the presence of BMDM showed a significant reduction in cell viability, indicating that the radicals produced from BMDM have a harmful influence on the skin. UVA exposure coincidently led to a reduction of UVA absorbance by BMDM. Interestingly, 2-hydroxy-4-methoxybenzophenone (Benzophenone-3; BP3) reduced both the radical formation and the cytotoxicity resulting from the UVA-exposure of BMDM, while also restoring its UVA absorbance. In conclusion, the results show that BMDM and BP3 is an effective combination to reduce the influence of UVA-exposed BMDM on the skin and to prevent the loss of UVA absorbance by BMDM during UV exposure.


Assuntos
Benzofenonas/farmacologia , Chalconas/efeitos adversos , Queratinócitos/efeitos dos fármacos , Queratinócitos/efeitos da radiação , Propiofenonas/farmacologia , Envelhecimento da Pele/efeitos dos fármacos , Luz Solar/efeitos adversos , Protetores Solares/farmacologia , Superóxidos/metabolismo , Raios Ultravioleta/efeitos adversos , Sobrevivência Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos da radiação , Células Cultivadas , Interações Medicamentosas , Estabilidade de Medicamentos , Humanos , Propiofenonas/efeitos adversos , Envelhecimento da Pele/patologia , Protetores Solares/efeitos adversos , Fatores de Tempo
5.
Clin Dermatol ; 38(4): 485-488, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32972607

RESUMO

Many factors affect the health and physiology of human skin, with some of them arising from outer space. This contribution explores four celestial influences on the skin: (1) the sun's ultraviolet light, which has both beneficial and deleterious dermatologic effects, (2) meteorite injuries, (3) possible lunar effects on the body's health, and (4) cosmic radiation as a risk factor for skin cancer and pregnancy-related complications. Some of these extraterrestrial influences on skin health have taken on added significance as human beings increasingly spend more time at higher altitudes in aircraft, spaceships, and space stations.


Assuntos
Radiação Cósmica/efeitos adversos , Neoplasias Cutâneas/etiologia , Pele/lesões , Pele/efeitos da radiação , Luz Solar/efeitos adversos , Raios Ultravioleta/efeitos adversos , Aeronaves , Altitude , Dermatite de Contato/etiologia , Feminino , Humanos , Masculino , Meteoroides , Lua , Gravidez , Complicações na Gravidez/etiologia
6.
Adv Exp Med Biol ; 1268: 3-15, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32918211

RESUMO

How to deal with the powerful rays of the sun represents a fundamental question of environmental medicine, affecting skin cancer prevention campaigns and many other aspects of public health. However, when preparing recommendations for sunlight exposure, physicians, scientists, and other health authorities are in a dilemma, because solar radiation exerts both positive and negative effects on human health. While positive effects are at least in part mediated via the UV(Ultraviolet)-B-induced cutaneous synthesis of vitamin D, negative effects include the UV-mediated photocarcinogenesis of skin cancer. During the last century, interest in the positive effects of the sun on our health increased dramatically after the introduction of the so-called vitamin D/cancer hypothesis. In the late 1930s, Peller and Stephenson reported higher rates of skin cancer but lower rates of other cancers among the US Navy personnel. Several years later, Apperly reported an association between latitude and cancer mortality rate in North America. He argued that the "relative immunity to cancer is a direct effect of sunlight". Although the hypothesis that sun exposure may be beneficial against cancer had been proposed early, these observations supporting the hypothesis were ignored for nearly 40 years, until a clear mechanism was proposed. In the 1980s, Garland and Garland published a pilot study focusing on colon cancer and suggested that the possible benefits of sun exposure could be attributed to vitamin D. Later, the proposed protective role of vitamin D was extended to many other types of cancer. Subsequent laboratory investigations supported potential anti-carcinogenic effects of vitamin D compounds. We know today that many, but not all, of the positive effects of the sun on human health are mediated by the UV-induced cutaneous synthesis of vitamin D and other photoproducts. However, because of the abovementioned dilemma, there is an ongoing controversial discussion in scientific communities and in the general population that how much sunlight is optimal for human health. This chapter summarizes the content of the third edition of "Sunlight, Vitamin D and Skin Cancer," a book specifically designed and organized to be an up-to-date review covering the most important aspects of the ongoing debate on how much sun is good for human health and how to balance between the positive and negative effects of solar and artificial UV-radiation, including lessons learned from Paleolithic models and evolution .


Assuntos
Saúde , Luz Solar , Humanos , Medição de Risco , Luz Solar/efeitos adversos , Raios Ultravioleta/efeitos adversos , Vitamina D
7.
Hautarzt ; 71(10): 772-785, 2020 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-32915242

RESUMO

The sun is of great importance for human health. One important reason for this is the production of vitamin D, endorphins and many other hormones by the skin due to stimulation by sunlight. Insufficient access to sunlight increases the risk for vitamin D deficiency, a pandemic which would affect more than one billion people worldwide and under which ca. 60% of the population in Germany would suffer. The skin has a unique position in vitamin D metabolism as elementary steps for vitamin D production take place here and it is furthermore a target organ for actions of vitamin D. Due to the many positive effects of the sun, a healthy balance must be found between UV protection to shield against skin cancer but also ensuring sufficient vitamin D production. For regulation of this fragile balance between photoprotection and vitamin D production, which has accompanied mankind throughout evolution, sunscreens are an integral part of the modern lifestyle, although critical reports on possible risks for their use have recently become more frequent. This article discusses the current state of knowledge on the importance of vitamin D metabolism in human skin and the use of sun creams.


Assuntos
Neoplasias Cutâneas/prevenção & controle , Luz Solar/efeitos adversos , Raios Ultravioleta/efeitos adversos , Vitamina D/uso terapêutico , Alemanha , Humanos , Protetores Solares , Terapia Ultravioleta , Deficiência de Vitamina D
9.
Artigo em Inglês | MEDLINE | ID: mdl-32854416

RESUMO

The Sun Exposure and Protection Index (SEPI) is a brief instrument for scoring of sun exposure habits and propensity to increase sun protection, previously validated in English and in Swedish, as well as in two different outdoor sun intensity environments (Australia and Northern Europe). The aim of the present study was to study reliability and validity of a German translated version of the SEPI to be used in German-speaking populations. Data was collected at University of Flensburg and at Hamburg University of Applied Sciences from November 2018 to April 2019. Participants (n = 205) filled out the SEPI and also a selection of corresponding questions from the Austrian Vienna UV Questionnaire in German. After three weeks, the participants filled out the SEPI once again in order to assess test-retest stability. Of the 205 participants completing the baseline questionnaire, 135 participants completed it once again after three weeks. Internal consistency, by Cronbach's alpha, for the baseline responses was 0.70 (95% C.I: 0.63-0.76) for SEPI part 1 (sun exposure habits) and 0.72 (95% C.I: 0.66-0.78) for part 2 (propensity to increase sun protection). Test-retest stability was high, with weighted Kappa >0.6 for all items but one, and the instrument correlated well with the previously validated German-language UV Skin Risk Survey Questionnaire. In conclusion, the German version of SEPI can reliably be used for mapping of individual sun exposure patterns.


Assuntos
Queimadura Solar/prevenção & controle , Luz Solar/efeitos adversos , Inquéritos e Questionários/normas , Alemanha , Humanos , Idioma , Reprodutibilidade dos Testes , Traduções
10.
PLoS One ; 15(8): e0237149, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32764774

RESUMO

PURPOSE: To investigate the association between daily sunlight exposure duration and diabetic retinopathy in Korean adults with diabetes. METHODS: This study used data from the 2008-2011 Korea National Health and Nutrition Examination Survey. Overall, 1,089 patients with diabetes aged >40 years were included. The duration of daily sunlight exposure was assessed via health interviews. Comprehensive ophthalmic evaluations, including standard retinal fundus photography after pupil dilation, were conducted. Diabetic retinopathy was graded using the modified Airlie House Classification. Multivariate logistic regression analysis was performed to analyze the association between daily sunlight exposure duration and the diagnosis of diabetic retinopathy and non-proliferative diabetic retinopathy. RESULTS: The risk of diabetic retinopathy was 2.66 times higher in the group with ≥5 h of daily sunlight exposure than in the group with less exposure after adjusting for risk factors such as duration of diabetes, serum hemoglobin A1c level, hypertension, and dyslipidemia (P = 0.023). Furthermore, the risk of non-proliferative diabetic retinopathy was 3.13 times higher in the group with ≥5 h of daily sunlight exposure than in the group with less exposure (P = 0.009). In patients with diabetes for <10 years, the risks of diabetic retinopathy and non-proliferative diabetic retinopathy were 4.26 and 4.82 times higher in the group with ≥5 h of daily sunlight exposure than the group with less exposure, respectively (P < 0.05). CONCLUSIONS: This study revealed that sunlight exposure for ≥5 h a day was significantly associated with an increased risk of diabetic retinopathy and non-proliferative diabetic retinopathy in Korean patients with diabetes. The risks were significantly higher in patients with diabetes for <10 years. Therefore, reducing daily sunlight exposure could be an early preventive strategy against diabetic retinopathy in people with diabetes.


Assuntos
Retinopatia Diabética/epidemiologia , Luz Solar/efeitos adversos , Idoso , Estudos Transversais , Retinopatia Diabética/diagnóstico , Retinopatia Diabética/etiologia , Retinopatia Diabética/prevenção & controle , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos Nutricionais/estatística & dados numéricos , Estresse Oxidativo/efeitos da radiação , Fotografação , Fotoperíodo , Prevalência , República da Coreia/epidemiologia , Retina/diagnóstico por imagem , Retina/efeitos da radiação , Fatores de Risco , Índice de Gravidade de Doença , Fatores de Tempo
11.
Hautarzt ; 71(8): 572-579, 2020 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-32494842

RESUMO

BACKGROUND: Ultraviolet radiation (UV)-induced malignancies, especially skin cancer, have continued to increase for decades. The main cause is natural and artificial UV radiation. The affected persons and the health care system are heavily burdened. The situation threatens to worsen, as climate change could lead to an increase in UV radiation exposure of the population and, thus, the risk of UV-related cancer in Germany as well. The prevention of UV-related diseases is, therefore, a health and radiation protection objective that needs to be considered. OBJECTIVE: Necessary and appropriate prevention measures for the precaution of UV-related cancer are presented. MATERIALS AND METHODS: The currently recommended and applied primary behavioral and structural preventive measures and potential, prevention-related relief for the health care system are examined and summarized. RESULTS: Numerous behavioral and structural preventive measures are already being applied. Sustainably designed, multicomponent and personalized behavioral preventive measures in combination with structural prevention modules are effective and have a high economic and health-related benefit. The use of modern media and multimedia measures is recommended. CONCLUSION: Structural prevention measures in addition to behavioral measures enable a reduction of the cancer risk caused by UV radiation. The aim must be to establish these measures nationwide for the entire population.


Assuntos
Melanoma/prevenção & controle , Proteção Radiológica , Neoplasias Cutâneas/prevenção & controle , Raios Ultravioleta/efeitos adversos , Exposição Ambiental/prevenção & controle , Alemanha , Promoção da Saúde , Humanos , Luz Solar/efeitos adversos , Protetores Solares/uso terapêutico
12.
Sci Rep ; 10(1): 7387, 2020 04 30.
Artigo em Inglês | MEDLINE | ID: mdl-32355183

RESUMO

Asian population is a low-risk group for basal cell carcinoma (BCC) and there is little data available in this setting. Sun-exposed BCC (SEBCC) may possess a different pathogenic mechanism from non-sun-exposed BCC (NSEBCC). To compare the histopathological profiles and outcomes between SEBCC and NSEBCC, and to assess the risk factors for tumor recurrences. Retrospective cohort study on 372 patients with pathologically diagnosed BCC from January 1, 1990 to August 31, 2017. Data were derived from a single medical center in Taiwan. SEBCC presented with higher Clark level and more high-risk factors for recurrence than NSEBCC. Nodular, micronodular, infiltrating/mixed infiltrating, basosquamous, and adenoid types were predominant in SEBCC, as superficial type in NSEBCC. Risk factors for recurrence included infiltrating/mixed-infiltrating subtypes and synchronous basosquamous cell carcinoma. No recurrence events were observed in NSEBCC. Our study showed an acceptable recurrence rate (4.2%) of the whole population after excision even under a smaller surgical margin width than suggested by current guidelines. SEBCC had a higher recurrence rate with a significantly different tumor characteristic from NSEBCC and a greater tumor depth than NSEBCC. A wider surgical margin in SEBCC than NSEBCC is suggested.


Assuntos
Carcinoma Basocelular , Neoplasias Cutâneas , Luz Solar/efeitos adversos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Carcinoma Basocelular/metabolismo , Carcinoma Basocelular/patologia , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Neoplasias Cutâneas/metabolismo , Neoplasias Cutâneas/patologia
13.
Sci Rep ; 10(1): 7812, 2020 05 08.
Artigo em Inglês | MEDLINE | ID: mdl-32385322

RESUMO

Health and performance impairments provoked by thermal stress are societal challenges geographically spreading and intensifying with global warming. Yet, science may be underestimating the true impact, since no study has evaluated effects of sunlight exposure on human brain temperature and function. Accordingly, performance in cognitively dominated and combined motor-cognitive tasks and markers of rising brainstem temperature were evaluated during exposure to simulated sunlight (equal to ~1000 watt/m2). Acute exposure did not affect any performance measures, whereas prolonged exposure of the head and neck provoked an elevation of the core temperature by 1 °C and significant impairments of cognitively dominated and motor task performances. Importantly, impairments emerged at considerably lower hyperthermia levels compared to previous experiments and to the trials in the presents study without radiant heating of the head. These findings highlight the importance of including the effect of sunlight radiative heating of the head and neck in future scientific evaluations of environmental heat stress impacts and specific protection of the head to minimize detrimental effects.


Assuntos
Cognição/fisiologia , Exercício Físico/fisiologia , Transtornos de Estresse por Calor/fisiopatologia , Luz Solar/efeitos adversos , Adulto , Temperatura Corporal , Regulação da Temperatura Corporal/fisiologia , Regulação da Temperatura Corporal/efeitos da radiação , Cognição/efeitos da radiação , Febre/etiologia , Febre/fisiopatologia , Cabeça/fisiopatologia , Cabeça/efeitos da radiação , Transtornos de Estresse por Calor/etiologia , Resposta ao Choque Térmico/fisiologia , Resposta ao Choque Térmico/efeitos da radiação , Temperatura Alta/efeitos adversos , Humanos , Masculino , Energia Solar , Análise e Desempenho de Tarefas
14.
J Surg Res ; 254: 147-153, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32445930

RESUMO

BACKGROUND: For the past 30 y, the incidence rate of malignant melanoma has risen steadily. Ultraviolet radiation exposure has been identified as the most prevalent modifiable risk factor for melanoma. Here, next-generation sequencing was used to analyze the relationship between multiple sun exposure factors and select cancer-related genes to determine the relationship of sun exposure on the molecular profiles of melanomas. METHODS: The collection and analysis of study samples were approved by the institutional review board. The patient cohort consisted of 173 patients whose melanoma tissue samples underwent next-generation sequencing analysis for somatic mutations of 50 cancer-related genes. Univariate and multivariate analyses were conducted. RESULTS: Patients with a history of blistering sunburn had an absolute mutation incidence of 1.67 mutations per patient, compared with patients without a history of blistering sunburn, who had an absolute mutation incidence of 1.16 mutations per patient (P = 0.028). A BRAF mutation was found in more tumors of patients who reported visiting a tanning salon (57.14%), compared with those who had not (18.75%; P = 0.0463). Patients with a previous history of skin cancer were more likely to have a CDKN2A mutation (20.83%), compared with those without a previous history of skin cancer (7.76%; P = 0.0292). CONCLUSIONS: The trends seen in the molecular profiles of melanomas with respect to various sun exposure factors suggest that sun exposure impacts genetic makeup. Considering the increase in absolute mutation incidence in patients with a history of blistering sunburn suggests that additional genes may contribute to the pathology of malignancy. Future studies will use the unique molecular profiles of melanomas to personalize patient treatments.


Assuntos
Sequenciamento de Nucleotídeos em Larga Escala , Melanoma/genética , Mutação/genética , Neoplasias Cutâneas/genética , Luz Solar/efeitos adversos , Raios Ultravioleta/efeitos adversos , Adulto , Idoso , Idoso de 80 Anos ou mais , Inibidor p16 de Quinase Dependente de Ciclina/genética , Feminino , Humanos , Masculino , Melanoma/epidemiologia , Pessoa de Meia-Idade , Proteínas Proto-Oncogênicas B-raf/genética , Neoplasias Cutâneas/epidemiologia , Banho de Sol/estatística & dados numéricos , Queimadura Solar/genética , Curtume , Proteína Supressora de Tumor p53/genética
15.
Aust N Z J Public Health ; 44(3): 208-214, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32459394

RESUMO

OBJECTIVE: Schools are an important setting for skin cancer prevention. An intervention for implementation of school sun safety policy, Sun Safety Schools (SSS), was evaluated. METHODS: Primary schools (n=118) in California school districts that had already adopted a sun safety policy were enrolled in a study with a randomised controlled design. Half of the schools were randomised to SSS intervention (N=58). Parents completed an online post-test. RESULTS: More parents in intervention schools received information about sun safety (mean=26.3%, sd=3.1%, p=0.017) and children more frequently wore sun-protective clothing when not at school (mean=2.93, sd=0.03, p=0.033) than in control schools (mean=18.0%, sd=2.5%; mean=2.83, sd=0.03, respectively). In schools where principals reported implementing sun safety practices, parents reported that children spent less time outdoors at midday (mean=14.78 hours, sd=0.25, p=0.033) and fewer were sunburned (mean=12.7%, sd=1.1%, p=0.009) than in non-implementing schools (M=16.3 hours, sd=0.67; mean=21.2%, sd=3.8%, respectively). Parents who received sun safety information (mean=3.08, sd=0.04, p=0.008) reported more child sun protection than parents not receiving information (mean=2.96, sd=0.02). CONCLUSIONS: A school district sun protection policy and support for implementation increased dissemination of sun safety information to parents and student sun safety. Implications for public health: Technical assistance for sun safety policies may increase sun protection of children.


Assuntos
Comunicação , Educação em Saúde/organização & administração , Promoção da Saúde/métodos , Pais , Serviços de Saúde Escolar/organização & administração , Estudantes/psicologia , Queimadura Solar/prevenção & controle , Luz Solar/efeitos adversos , Adolescente , Austrália , Criança , Feminino , Política de Saúde , Humanos , Masculino , Política Organizacional , Avaliação de Processos em Cuidados de Saúde , Instituições Acadêmicas , Raios Ultravioleta/efeitos adversos
16.
Plast Reconstr Surg ; 145(6): 1037e-1049e, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32459770

RESUMO

BACKGROUND: The major intrinsic cause of facial skin degeneration is age, associated with extrinsic factors such as exposure to sun. Its major pathologic causes are degeneration of the elastin matrix, with loss of oxytalan and elaunin fibers in the subepidermal region, and actinic degeneration of elastin fibers that lose their functional properties in the deep dermis. Therapy using autologous adipose mesenchymal stem cells for regeneration of extracellular matrix in patients with solar elastosis was addressed in qualitative and quantitative analyses of the dermal elastic fiber system and the associated cells. METHODS: Mesenchymal stem cells were obtained from lipoaspirates, expanded in vitro, and introduced into the facial skin of patients submitted after 3 to 4 months to a face-lift operation. In the retrieved skin, immunocytochemical analyses quantified elastic matrix components; cathepsin K; matrix metalloproteinase 12 (macrophage metalloelastase); and the macrophage M2 markers CD68, CD206, and hemeoxygenase-1. RESULTS: A full de novo formation of oxytalan and elaunin fibers was observed in the subepidermal region, with reconstitution of the papillary structure of the dermal-epidermal junction. Elastotic deposits in the deep dermis were substituted by a normal elastin fiber network. The coordinated removal of the pathologic deposits and their substitution by the normal ones was concomitant with activation of cathepsin K and matrix metalloproteinase 12, and with expansion of the M2 macrophage infiltration. CONCLUSION: The full regeneration of solar elastosis was obtained by injection of in vitro expanded autologous adipose mesenchymal stem cells, which are appropriate, competent, and sufficient to elicit the full structural regeneration of the sun-aged skin. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.


Assuntos
Tecido Adiposo/citologia , Transplante de Células-Tronco Mesenquimais/métodos , Cuidados Pré-Operatórios/métodos , Ritidoplastia , Envelhecimento da Pele , Idoso , Biópsia , Brasil , Elastina/análise , Elastina/metabolismo , Matriz Extracelular/metabolismo , Proteínas da Matriz Extracelular/análise , Proteínas da Matriz Extracelular/metabolismo , Face , Feminino , Seguimentos , Voluntários Saudáveis , Humanos , Masculino , Pessoa de Meia-Idade , Rejuvenescimento , Pele/patologia , Pele/efeitos da radiação , Luz Solar/efeitos adversos , Transplante Autólogo/métodos , Resultado do Tratamento
17.
Orv Hetil ; 161(16): 632-636, 2020 04 01.
Artigo em Húngaro | MEDLINE | ID: mdl-32323967

RESUMO

Solar retinopathy is the photochemical and thermic injury of the retinal photoreceptors and the pigment epithelium caused by ultraviolet (UV) radiation. As a consequence, the most common symptoms are visual acuity deterioration, blurred vision and positive scotoma. Optical coherence tomography (OCT), microperimetry and fluorescein angiography (FLA) are helpful in determining the diagnosis. Authors present an 18-year-old male having central scotomas affecting both eyes who presented at the Department of Ophtalmology of Semmelweis University. OCT scans revealed a localised defect and hyperreflectivity of certain retinal layers and microperimetry examination detected decreased retinal sensitivity consistent with the lesions. After a follow-up of 6 months, the defect of the right eye became more subtle and the one on the left disappeared completely. Microperimetry results correlated with OCT findings. Subjective symptoms on the right eye decreased significantly and they do not affect his daily life anymore, symptoms on the left eye discontinued. Currently, no specific therapy exists for solar retinopathy. Symptoms and defects in favourable cases normalise in 3­6 months which highlights the importance of public health education and prevention. Orv Hetil. 2020; 161(16): 632­636.


Assuntos
Doenças Retinianas/diagnóstico por imagem , Doenças Retinianas/etiologia , Luz Solar/efeitos adversos , Adolescente , Angiofluoresceinografia , Humanos , Masculino , Imagem Multimodal , Tomografia de Coerência Óptica
18.
Oncogene ; 39(21): 4170-4182, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32277233

RESUMO

Nonmelanoma skin cancer (NMSC) such as cutaneous squamous cell carcinoma (cSCC) is caused by solar ultraviolet (SUV) exposure and is the most common cancer in the United States. T-LAK cell-originated protein kinase (TOPK), a serine-threonine kinase is activated by SUV irradiation and involved in skin carcinogenesis. Strategies with research focusing on the TOPK signaling pathway and targeted therapy in skin carcinogenesis may helpful for the discovery of additional treatments against skin cancer. In this study, we found that TOPK can directly bind to and phosphorylate c-Jun (as one of the core member of AP-1) at Ser63 and Ser73 after SSL exposure in a JNKs-independent manner. TOPK knocking down, or HI-TOPK-032 (TOPK specific inhibitor) attenuated colony formation and cell proliferation of skin cancer cells. Phosphorylated levels of c-Jun were overexpressed in human AK and cSCC compared with normal skin tissues, and HI-TOPK-032 inhibited the phosphorylation of c-Jun in SCC cell line in a dose-dependent manner. Furthermore, HI-TOPK-032 decreased SSL-induced AP-1 transactivation activity. Moreover, acute SSL-induced inflammation was attenuated by the topical application of HI-TOPK-032 in SKH1 hairless mice. Importantly, HI-TOPK-032 suppressed chronic SSL-induced skin carcinogenesis and c-Jun phosphorylation levels in SKH1 hairless mice. Our results demonstrate that TOPK can phosphorylate and activate c-Jun at Ser63 and Ser73 in the process of skin carcinogenesis and HI-TOPK-032 could be used as a potential chemopreventive drug against cSCC development.


Assuntos
Carcinogênese , Indolizinas/farmacologia , Quinases de Proteína Quinase Ativadas por Mitógeno , Proteínas de Neoplasias , Inibidores de Proteínas Quinases/farmacologia , Quinoxalinas/farmacologia , Neoplasias Cutâneas , Luz Solar/efeitos adversos , Raios Ultravioleta/efeitos adversos , Animais , Carcinogênese/efeitos dos fármacos , Carcinogênese/genética , Carcinogênese/metabolismo , Carcinogênese/efeitos da radiação , Humanos , Camundongos , Camundongos Pelados , Camundongos Knockout , Quinases de Proteína Quinase Ativadas por Mitógeno/antagonistas & inibidores , Quinases de Proteína Quinase Ativadas por Mitógeno/genética , Quinases de Proteína Quinase Ativadas por Mitógeno/metabolismo , Proteínas de Neoplasias/antagonistas & inibidores , Proteínas de Neoplasias/genética , Proteínas de Neoplasias/metabolismo , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Cutâneas/enzimologia , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/patologia
19.
Isr Med Assoc J ; 22(4): 227-231, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32286025

RESUMO

BACKGROUND: Solar urticaria (SU) is a rare and disabling photodermatosis. SU typically manifests as urticarial wheals and erythema appearing shortly after sun exposure. SU is often initially diagnosed clinically with subsequent confirmation through photoprovocation tests. Early diagnosis is important for correct management of patients. OBJECTIVES: To present the clinical features of three cases of atypical presentation of SU and to discuss possible underlying mechanisms. METHODS: We report a series of three patients who presented with transient pruritic erythema without wheals after sun exposure. All patients had photoprovocation tests conducted to confirm SU diagnosis and to determine their action spectra. Treatment outcomes were recorded. RESULTS: All three patients developed classical manifestations of SU during photoprovocation tests within the UVA1 spectrum. Two patients required high-dose irradiation to provoke urticaria. CONCLUSIONS: Erythema without urticaria can be the primary manifestation of SU, especially in countries with sunny climates where natural skin hardening is common. Such cases require a high index of suspicion for SU and highlight the importance of photoprovocation testing to confirm the diagnosis.


Assuntos
Omalizumab/uso terapêutico , Transtornos de Fotossensibilidade/diagnóstico , Prurido/etiologia , Luz Solar/efeitos adversos , Urticária/etiologia , Adulto , Diagnóstico Diferencial , Eritema/diagnóstico , Eritema/etiologia , Feminino , Seguimentos , Humanos , Masculino , Transtornos de Fotossensibilidade/tratamento farmacológico , Prurido/diagnóstico , Prurido/tratamento farmacológico , Medição de Risco , Amostragem , Testes Cutâneos/métodos , Fatores de Tempo , Resultado do Tratamento , Urticária/diagnóstico , Urticária/tratamento farmacológico
20.
Eur J Cancer ; 128: 60-82, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32113941

RESUMO

Invasive cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in the white populations, accounting for 20% of all cutaneous malignancies. Factors implicated in cSCC etiopathogenesis include ultraviolet radiation exposure and chronic photoaging, age, male sex, immunosuppression, smoking and genetic factors. A collaboration of multidisciplinary experts from the European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organisation of Research and Treatment of Cancer (EORTC) was formed to update recommendations on cSCC classification, diagnosis, risk stratification, staging and prevention, based on current literature, staging systems and expert consensus. Common cSCCs are typically indolent tumors, and most have a good prognosis with 5-year cure rates of greater than 90%, and a low rate of metastases (<4%). Further risk stratification into low-risk or high-risk common primary cSCC is recommended based on proposed high-risk factors. Advanced cSCC is classified as locally advanced (lacSCC), and metastatic (mcSCC) including locoregional metastatic or distant metastatic cSCC. Current systems used for staging include the American Joint Committee on Cancer (AJCC) 8th edition, the Union for International Cancer Control (UICC) 8th edition, and Brigham and Women's Hospital (BWH) system. Physical examination for all cSCCs should include total body skin examination and clinical palpation of lymph nodes, especially of the draining basins. Radiologic imaging such as ultrasound of the regional lymph nodes, magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography-computed tomography (PET-CT) scans are recommended for staging of high-risk cSCC. Sentinel lymph node biopsy is currently not recommended. Nicotinamide, oral retinoids, and topical 5-FU have been used for the chemoprevention of subsequent cSCCs in high-risk patients but are not routinely recommended. Education about sun protection measures including reducing sun exposure, use of protective clothing, regular use of sunscreens and avoidance of artificial tanning, is recommended.


Assuntos
Carcinoma de Células Escamosas/diagnóstico , Consenso , Dermatologia/normas , Oncologia/normas , Neoplasias Cutâneas/diagnóstico , Carcinoma de Células Escamosas/etiologia , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/prevenção & controle , Humanos , Linfonodos/diagnóstico por imagem , Imagem por Ressonância Magnética/normas , Estadiamento de Neoplasias/normas , Educação de Pacientes como Assunto/normas , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/normas , Roupa de Proteção/normas , Medição de Risco/normas , Pele/diagnóstico por imagem , Pele/patologia , Neoplasias Cutâneas/etiologia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/prevenção & controle , Sociedades Médicas/normas , Luz Solar/efeitos adversos , Protetores Solares/administração & dosagem , Ultrassonografia/normas
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA