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2.
Medicine (Baltimore) ; 98(52): e18434, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31876722

RESUMO

RATIONALE: Although lipomas are the most common benign form of soft tissue tumor in the body, giant lipomas of the hand, defined as >5 cm in diameter, are extremely rare. PATIENT CONCERNS: A 49-year-old man presented with a soft and fixed lump in the left hypothenar area. The mass was not tender, but it was associated with symptoms of tingling sensation and paresthesia in the left ring and little fingers that had lasted for 4 years. DIAGNOSES: Preoperative image studies revealed an encapsulated and multilobulated mass, which measured 8 cm × 5 cm × 2 cm. Basic histologic examination identified the specimen as a lipoma and further immunohistochemical studies ruled out the possibility of malignancy. INTERVENTIONS: To enable a complete excision of the mass, the palmar digital branch of the ulnar nerve for the little finger passing through the mass was temporarily transected. After complete excision of the mass, the branch was coapted again under microscopy. OUTCOMES: Complete sensory recovery was achieved 6 months after surgery, without any sign of recurrence. LESSONS: Although giant lipomas in the hand can extend to vital components such as neurovascular structures, muscles, and tendons, meticulous en bloc resection can provide excellent results without any complications.


Assuntos
Mãos , Lipoma/diagnóstico , Neoplasias de Tecidos Moles/diagnóstico , Mãos/diagnóstico por imagem , Mãos/patologia , Mãos/cirurgia , Humanos , Lipoma/diagnóstico por imagem , Lipoma/patologia , Lipoma/cirurgia , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neoplasias de Tecidos Moles/diagnóstico por imagem , Neoplasias de Tecidos Moles/patologia , Neoplasias de Tecidos Moles/cirurgia , Tomografia Computadorizada por Raios X
3.
Am J Orthod Dentofacial Orthop ; 156(3): 383-390, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31474268

RESUMO

INTRODUCTION: The aim of this study was to evaluate the height growth of Class I and III orthodontic patients according to the Fishman skeletal maturation index (SMI) and to compare it with that of a general population. METHODS: The study sample included 81 Class I and 71 Class III adolescents who had height measurements and hand-wrist radiographs taken annually and categorized according to SMI. Height completion rate, residual height, height increase per sequential SMI stage, and height velocity were analyzed. Sex differences were evaluated and comparisons between Class I and Class III groups were made. In addition, the height of orthodontic patients was indirectly compared with that of the general population. RESULTS: In boys and girls, height completion rate was >90% at SMI 6, residual height was fewer than 10 cm at SMI 7, and height increase per sequential SMI stage was greatest from SMI 6 to SMI 7. Height velocity was greatest from SMI 5 to SMI 6 in boys and from SMI 4 to SMI 5 in girls. CONCLUSIONS: There was no significant difference in body height parameters for all SMI stages between Class I and Class III adolescents. Adolescents who had orthodontic treatment were not shorter in stature at growth completion compared with the general population.


Assuntos
Estatura , Má Oclusão de Angle Classe III/terapia , Má Oclusão de Angle Classe II/terapia , Ortodontia Corretiva , Adolescente , Determinação da Idade pelo Esqueleto , Desenvolvimento Ósseo , Criança , Feminino , Gráficos de Crescimento , Mãos/diagnóstico por imagem , Mãos/crescimento & desenvolvimento , Ossos da Mão/diagnóstico por imagem , Ossos da Mão/crescimento & desenvolvimento , Humanos , Estudos Longitudinais , Masculino , Radiografia , República da Coreia , Estudos Retrospectivos , Fatores Sexuais , Punho/diagnóstico por imagem , Punho/crescimento & desenvolvimento
4.
J Physiol Anthropol ; 38(1): 9, 2019 Aug 08.
Artigo em Inglês | MEDLINE | ID: mdl-31395098

RESUMO

BACKGROUND: High-resolution ultrasound is being widely used in carpal tunnel examination to understand morphological and biomechanical characteristics of the median nerve and surrounding anatomy structures. MAIN BODY: Healthy young and elderly men were recruited. The median nerve at proximal wrist region was examined by ultrasound imaging technique. A total of seven wrist angle was examined. Generally, the median nerve cross-sectional area of the elderly group is significantly larger than the young group. SHORT CONCLUSION: Wrist posture in greater flexion or extension caused a larger decrease in the median nerve cross-sectional area across both groups.


Assuntos
Envelhecimento/fisiologia , Mãos/diagnóstico por imagem , Nervo Mediano/diagnóstico por imagem , Postura/fisiologia , Adulto , Idoso , Humanos , Masculino , Ultrassonografia , Punho/diagnóstico por imagem , Adulto Jovem
5.
BMC Med Genet ; 20(1): 133, 2019 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-31370824

RESUMO

BACKGROUND: Proximal symphalangism (SYM1; OMIM 185800), also called Cushing's symphalangism, is an infrequent autosomal dominant disease. An SYM1 patient typically features variable fusion of proximal interphalangeal joints in the hands and feet. METHODS: We recruited a four-generation Chinese non-consanguineous family with SYM1. We examined their hands and feet using X-rays to confirm fusion of proximal interphalangeal joints. We evaluated their audiology using standard audiometric procedures and equipment. Then, we identified genetic variants using whole exome sequencing and validated mutations using Sanger sequencing. Mutation pathogenicity was analyzed with bioinformatics. RESULTS: Radiographs revealed proximal-joint fusion of fingers and toes in the patients. Two elderly individuals (II:1 and II:4) exhibited slight hearing loss. Additionally, we detected a novel heterozygous missense mutation in exon 1 of NOG (NM_005450) c.124C > T, p.(Pro42Ser) in all patients. This c.124C > T mutation is highly conserved across multiple species and the p.(Pro42Ser) variation is potentially highly pathogenic. CONCLUSION: Our results suggest that heterozygous c.124C > T, p.(Pro42Ser) in NOG is a novel mutation that causes human SYM1 phenotype.


Assuntos
Grupo com Ancestrais do Continente Asiático/genética , Proteínas de Transporte/genética , Articulações dos Dedos/anormalidades , Predisposição Genética para Doença/genética , Artropatias/congênito , Mutação de Sentido Incorreto , Sequência de Aminoácidos , Sequência de Bases , Éxons , Articulações dos Dedos/diagnóstico por imagem , Articulações dos Dedos/fisiopatologia , Pé/diagnóstico por imagem , Mãos/diagnóstico por imagem , Perda Auditiva/genética , Heterozigoto , Humanos , Artropatias/diagnóstico por imagem , Artropatias/genética , Artropatias/fisiopatologia , Modelos Moleculares , Linhagem , Fenótipo , Análise de Sequência de DNA , Análise de Sequência de Proteína , Sequenciamento Completo do Exoma
6.
Sensors (Basel) ; 19(17)2019 Aug 28.
Artigo em Inglês | MEDLINE | ID: mdl-31466235

RESUMO

The dorsal hand vein images captured by cross-device may have great differences in brightness, displacement, rotation angle and size. These deviations must influence greatly the results of dorsal hand vein recognition. To solve these problems, the method of dorsal hand vein recognition was put forward based on bit plane and block mutual information in this paper. Firstly, the input gray image of dorsal hand vein was converted to eight-bit planes to overcome the interference of brightness inside the higher bit planes and the interference of noise inside the lower bit planes. Secondly, the texture of each bit plane of dorsal hand vein was described by a block method and the mutual information between blocks was calculated as texture features by three kinds of modes to solve the problem of rotation and size. Finally, the experiments cross-device were carried out. One device was used to be registered, the other was used to recognize. Compared with the SIFT (Scale-invariant feature transform, SIFT) algorithm, the new algorithm can increase the recognition rate of dorsal hand vein from 86.60% to 93.33%.


Assuntos
Mãos/diagnóstico por imagem , Processamento de Imagem Assistida por Computador/métodos , Reconhecimento Automatizado de Padrão/métodos , Veias/diagnóstico por imagem , Algoritmos , Humanos
7.
Biomed Res Int ; 2019: 5610849, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31467897

RESUMO

Left-handers show lower asymmetry in manual ability when compared to right-handers. Unlike right-handers, left-handers do not show larger deactivation of the ipsilateral primary sensorimotor (SM1) cortex on functional magnetic resonance imaging when moving their dominant than their nondominant hand. However, it should be noted that morphometric MRI studies have reported no differences between right-handers and left-handers in volume, thickness, or surface area of the SM1 cortex. In this regard, magnetization transfer (MT) imaging is a technique with the potential to provide information on microstructural organization and macromolecular content of tissue. In particular, MT ratio index of the brain gray matter is assumed to reflect the variable content of afferent or efferent myelinated fibers, with higher MT ratio values being associated with increased fibers number or degree of myelination. The aim of this study was hence to assess, for the first time, through quantitative MT ratio measurements, potential differences in microstructural organization/characteristics of SM1 cortex between left- and right-handers, which could underlay handedness side. Nine left-handed and 9 right-handed healthy subjects, as determined by the Edinburgh handedness inventory, were examined with T1-weighted and MT-weighted imaging on a 3 T scanner. The hands of subjects were kept still during all acquisitions. Using FreeSurfer suite and the automatic anatomical labeling parcellations defined by the Destrieux atlas, we measured MT ratio, as well as cortical thickness, in three regions of interests corresponding to the precentral gyrus, the central sulcus, and the postcentral gyrus in the bilateral SM1 cortex. No significant difference between left- and right-handers was revealed in the thickness of the three partitions of the SM1 cortex. However, left-handers showed a significantly (p = 0.007) lower MT ratio (31.92% ± 0.96%) in the right SM1 central sulcus (i.e., the hand representation area for left-handers) as compared to right-handers (33.28% ± 0.94%). The results of this preliminary study indicate that quantitative MT imaging, unlike conventional morphometric MRI measurements, can be a useful tool to reveal, in SM1 cortex, potential microstructural correlates of handedness side.


Assuntos
Lateralidade Funcional/fisiologia , Movimento/fisiologia , Córtex Sensório-Motor/fisiologia , Adulto , Mapeamento Encefálico , Feminino , Mãos/diagnóstico por imagem , Mãos/fisiologia , Humanos , Processamento de Imagem Assistida por Computador , Imagem por Ressonância Magnética , Masculino , Córtex Motor/diagnóstico por imagem , Córtex Motor/fisiologia , Lobo Occipital/fisiologia , Córtex Sensório-Motor/diagnóstico por imagem
8.
Cell Prolif ; 52(5): e12667, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31373101

RESUMO

OBJECTIVE: Interstitial fluid in extracellular matrices may not be totally fixed but partially flow through long-distance oriented fibrous connective tissues via physical mechanisms. We hypothesized there is a long-distance interstitial fluid transport network beyond vascular circulations. MATERIALS AND METHODS: We first used 20 volunteers to determine hypodermic entrant points to visualize long-distance extravascular pathway by MRI. We then investigated the extravascular pathways initiating from the point of thumb in cadavers by chest compressor. The distributions and structures of long-distance pathways from extremity ending to associated visceral structures were identified. RESULTS: Using fluorescent tracer, the pathways from right thumb to right atrium wall near chest were visualized in seven of 10 subjects. The cutaneous pathways were found in dermic, hypodermic and fascial tissues of hand and forearm. The perivascular pathways were along the veins of arm, axillary sheath, superior vena cava and into the superficial tissues on right atrium. Histological and micro-CT data showed these pathways were neither blood nor lymphatic vessels but long-distance oriented fibrous matrices, which contained the longitudinally assembled micro-scale fibres consistently from thumb to superficial tissues on right atrium. CONCLUSIONS: These data revealed the structural framework of the fibrous extracellular matrices in oriented fibrous connective tissues was of the long-distance assembled fibres throughout human body. Along fibres, interstitial fluid can systemically transport by certain driving-transfer mechanisms beyond vascular circulations.


Assuntos
Tecido Conjuntivo/metabolismo , Matriz Extracelular/metabolismo , Pontos de Acupuntura , Adulto , Cadáver , Tecido Conjuntivo/química , Tecido Conjuntivo/patologia , Meios de Contraste/química , Meios de Contraste/metabolismo , Feminino , Fluoresceína/química , Fluoresceína/metabolismo , Pé/diagnóstico por imagem , Mãos/diagnóstico por imagem , Humanos , Vasos Linfáticos/anatomia & histologia , Vasos Linfáticos/diagnóstico por imagem , Imagem por Ressonância Magnética , Masculino , Microscopia Confocal , Pontos Quânticos/química , Pontos Quânticos/metabolismo , Adulto Jovem
9.
Muscle Nerve ; 60(4): 387-391, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31294856

RESUMO

BACKGROUND: This study evaluated muscle echo intensity (EI) ratio in patients with ulnar neuropathy at the elbow (UNE) and healthy controls. METHODS: In this prospective study, 28 patients with electrodiagnostically confirmed unilateral UNE and 12 healthy controls were ultrasonographically assessed for EI ratios of the hypothenar and thenar muscles. The affected and unaffected hands between the UNE patients and controls and patient subgroups (subdivided according to electrodiagnostic severity) were compared to determine any significant differences. RESULTS: In patients with UNE, the EI ratio of the hypothenar to thenar muscles was significantly higher for the affected side than for the unaffected side (1.08 ± 0.11 and 0.97 ± 0.18, respectively) or the control group (0.95 ± 0.05). A significant difference in the EI ratio was observed among the subgroups (mild vs. severe subgroup, P < 0.01). CONCLUSIONS: Ultrasonographic EI measurement may be a useful parameter in the evaluation and screening of UNE.


Assuntos
Mãos/diagnóstico por imagem , Músculo Esquelético/diagnóstico por imagem , Neuropatias Ulnares/diagnóstico por imagem , Adulto , Idoso , Área Sob a Curva , Estudos de Casos e Controles , Eletrodiagnóstico , Feminino , Humanos , Masculino , Nervo Mediano , Pessoa de Meia-Idade , Músculo Esquelético/inervação , Projetos Piloto , Estudos Prospectivos , Curva ROC , Sensibilidade e Especificidade , Nervo Ulnar/fisiopatologia , Neuropatias Ulnares/fisiopatologia
10.
Sensors (Basel) ; 19(13)2019 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-31266251

RESUMO

Hand pose estimation is a critical technology of computer vision and human-computer interaction. Deep-learning methods require a considerable amount of tagged data. Accordingly, numerous labeled training data are required. This paper aims to generate depth hand images. Given a ground-truth 3D hand pose, the developed method can generate depth hand images. To be specific, a ground truth can be 3D hand poses with the hand structure contained, while the synthesized image has an identical size to that of the training image and a similar visual appearance to the training set. The developed method, inspired by the progress in the generative adversarial network (GAN) and image-style transfer, helps model the latent statistical relationship between the ground-truth hand pose and the corresponding depth hand image. The images synthesized using the developed method are demonstrated to be feasible for enhancing performance. On public hand pose datasets (NYU, MSRA, ICVL), comprehensive experiments prove that the developed method outperforms the existing works.


Assuntos
Biometria/métodos , Mãos/anatomia & histologia , Processamento de Imagem Assistida por Computador/métodos , Interface Usuário-Computador , Algoritmos , Aprendizado Profundo , Mãos/diagnóstico por imagem , Humanos
11.
Sensors (Basel) ; 19(13)2019 Jun 27.
Artigo em Inglês | MEDLINE | ID: mdl-31252557

RESUMO

Various convolutional neural network (CNN)-based approaches have been recently proposed to improve the performance of motor imagery based-brain-computer interfaces (BCIs). However, the classification accuracy of CNNs is compromised when target data are distorted. Specifically for motor imagery electroencephalogram (EEG), the measured signals, even from the same person, are not consistent and can be significantly distorted. To overcome these limitations, we propose to apply a capsule network (CapsNet) for learning various properties of EEG signals, thereby achieving better and more robust performance than previous CNN methods. The proposed CapsNet-based framework classifies the two-class motor imagery, namely right-hand and left-hand movements. The motor imagery EEG signals are first transformed into 2D images using the short-time Fourier transform (STFT) algorithm and then used for training and testing the capsule network. The performance of the proposed framework was evaluated on the BCI competition IV 2b dataset. The proposed framework outperformed state-of-the-art CNN-based methods and various conventional machine learning approaches. The experimental results demonstrate the feasibility of the proposed approach for classification of motor imagery EEG signals.


Assuntos
Interfaces Cérebro-Computador , Eletroencefalografia/métodos , Mãos/diagnóstico por imagem , Movimento/fisiologia , Algoritmos , Análise de Fourier , Mãos/fisiologia , Humanos , Imaginação/fisiologia , Aprendizado de Máquina
12.
Handchir Mikrochir Plast Chir ; 51(3): 177-184, 2019 Jun.
Artigo em Alemão | MEDLINE | ID: mdl-31167278

RESUMO

BACKGROUND: Mobile X-ray imaging systems are standard in the operating theatre. Mini-C-arms are the prevailing technology in hand surgery. Unfortunately, the exposure to Mini-C-arm radiation is often underestimated. METHODS: For one year, the intraoperative radiation dose delivered by an OrthoScan High Definition Mini-C-arm with a flat panel detector was measured using headband and finger ring dosimeters in all hand and wrist surgeries performed by three experienced hand surgeons. RESULTS: Two hundred and thirteen patients underwent surgical treatment involving the use of an OrthoScan High Definition Mini-C-arm. The total radiation dose administered by all three hand surgeons over 12 months was 9033.39 mGy with a total irradiation time of 376:38 min. A radiation exposure of 2.0 mSv was detected on both finger ring dosimeters of one surgeon during one month. For all other dosimeters, the monthly radiation exposure was below the detection limit of < 0.3 mSv. CONCLUSION: The radiation exposure reached during about 100 surgeries/surgeon/year involving the use of an OrthoScan Mini-C-arm does not exceed the annual occupational exposure limits of 50 mSv for the hand and 20 mSv for the lens of the eye. Only at an X-ray exposure of 800-1000 mGy/month can radiation exposure be detected with a finger ring dosimeter (measuring range 0.3 mSv-10 Sv) in a hand surgeon. Due to the potential health risk posed by stochastic radiation effects, all possible safeguards including behavioural measures should be observed.


Assuntos
Mãos , Exposição Ocupacional , Exposição à Radiação , Lesões por Radiação , Fluoroscopia , Mãos/diagnóstico por imagem , Mãos/cirurgia , Humanos , Doses de Radiação
13.
Nat Commun ; 10(1): 2401, 2019 06 03.
Artigo em Inglês | MEDLINE | ID: mdl-31160580

RESUMO

Neurotechnology attempts to develop supernumerary limbs, but can the human brain deal with the complexity to control an extra limb and yield advantages from it? Here, we analyzed the neuromechanics and manipulation abilities of two polydactyly subjects who each possess six fingers on their hands. Anatomical MRI of the supernumerary finger (SF) revealed that it is actuated by extra muscles and nerves, and fMRI identified a distinct cortical representation of the SF. In both subjects, the SF was able to move independently from the other fingers. Polydactyly subjects were able to coordinate the SF with their other fingers for more complex movements than five fingered subjects, and so carry out with only one hand tasks normally requiring two hands. These results demonstrate that a body with significantly more degrees-of-freedom can be controlled by the human nervous system without causing motor deficits or impairments and can instead provide superior manipulation abilities.


Assuntos
Córtex Cerebral/diagnóstico por imagem , Dedos/diagnóstico por imagem , Movimento/fisiologia , Músculo Esquelético/diagnóstico por imagem , Polidactilia/diagnóstico por imagem , Adolescente , Encéfalo/diagnóstico por imagem , Encéfalo/fisiologia , Córtex Cerebral/fisiologia , Feminino , Dedos/fisiologia , Neuroimagem Funcional , Mãos/diagnóstico por imagem , Mãos/fisiologia , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/fisiologia , Polidactilia/fisiopatologia
14.
PLoS One ; 14(5): e0214714, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31042723

RESUMO

Solar lentigo, benign lesions which mostly appear on chronically, sun-exposed surfaces, are associated with ageing. Patients are increasingly requesting a more uniform skin texture, especially for hands. Treatment options include dermoabrasion, intense pulsed light, cryotherapy, peelings, and laser therapy. Topical compounds can be employed, in alternative or associated with dermatologic procedures. The current study was designed to evaluate solar lentigo hyperpigmentation, skin architecture and clinician and patient assessments comparing a dermocosmetic lightening product (active) with a moisturizing product (control) according to clinical, digital and subjective analyses in 72 lesions over 12-month follow up period. Statistically significant differences were observed between the lesions treated with the active compared to the control in terms of papillary brightness (p = 0.03) and contrast (p = 0.03), and in the limitation of dermal-epidermal junction destructuring (p = 0.03) according to dermal-epidermal junction destructuring score at Reflectance Confocal Microscopy. Luminance (p = 0.04) and redness (p = 0.03) were improved at color analysis, and physician and patient evaluations favored the active in efficacy and patient satisfaction investigations. The dermocosmetic lightening product utilized in the current study proved to be more effective, according to clinical, digital and subjective analyses in reducing lesion hyperpigmentation, stabilizing the lesion skin architecture and increasing patient satisfaction compared to the control in a cohort of 36 subjects, over a 12-month period. Beside demonstrating the efficacy of this topical lightening product, we propose a "destructuring score", which improves the robustness of solar lentigo's evaluation, and can be used in future studies to standardize the quantitative comparisons of different treatment options.


Assuntos
Mãos/patologia , Lentigo/tratamento farmacológico , Preparações Clareadoras de Pele/administração & dosagem , Administração Tópica , Idoso , Feminino , Mãos/diagnóstico por imagem , Humanos , Itália , Lentigo/diagnóstico por imagem , Lentigo/patologia , Masculino , Microscopia Confocal , Pessoa de Meia-Idade , Satisfação do Paciente , Preparações Clareadoras de Pele/uso terapêutico , Resultado do Tratamento
16.
Eur Radiol ; 29(11): 6345-6354, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31028442

RESUMO

OBJECTIVES: Optimal management of rheumatoid arthritis (RA) depends on accurate evaluation of disease activity. Foot synovitis is not included in the most used RA outcome measure (DAS-28 score). The aim of this study was to investigate how musculoskeletal ultrasound (MSK-US) examination of hand and feet correlate with the disease activity score (DAS-28 score). We also explored whether performing MSK-US assessments of hands alone compared with hands and feet underestimates the disease activity in RA. METHODS: This is a real-life cross-sectional study of 101 patients (51 with RA and 50 with other musculoskeletal conditions) with inflammatory small joint pain, who underwent MSK-US examination of hands and feet. RESULTS: MSK-US-detected hand synovitis was found in 18/51 (35.3%) RA patients and 16/50 (32%) of those with other musculoskeletal conditions (p = 0.96), while foot synovitis was detected in 18/51 (35.3%) and 12/50 (24%) patients, respectively (p = 0.78). DAS-28 did not correlate with any of the US outcome measures in patients with RA. Six out of 13 (46.1%) RA patients in remission, 7/14 (50%) with low disease activity and 18/32 (56.2%) with moderate disease activity (according to DAS-28 definition) had active synovitis as assessed by the MSK-US examination of their hands and feet. MSK-US-detected synovitis led to treatment escalation in 26/51 (51%) RA patients. CONCLUSION: This study emphasises that MSK-US examination of hands and feet has led to optimised management of the majority of RA patients, which would have not been possible otherwise, because of the lack of correlation between DAS-28 assessment and MSK-US outcomes. KEY POINTS: • The most used disease activity score in rheumatoid arthritis (DAS-28) did not correlate with US outcome measures derived from hands and feet examination. • DAS-28 did not differentiate between RA patients with subclinical active synovitis versus well-controlled disease on US. • As a result of US examination of the hands and feet, 51% RA patients had their immunosuppressive treatment optimised.


Assuntos
Artrite Reumatoide/diagnóstico , Pé/diagnóstico por imagem , Mãos/diagnóstico por imagem , Sinovite/diagnóstico por imagem , Ultrassonografia Doppler , Adulto , Idoso , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
17.
J Med Ultrason (2001) ; 46(4): 489-495, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30989442

RESUMO

PURPOSE: This study sought to compare ultrasound-guided measurements of the abductor pollicis brevis (APB) using the water bath technique (WBT) and the direct contact method (DM) and investigate whether the DM can reproduce the measurements that would be obtained with a non-contact method, such as the WBT. METHODS: The APB muscles of 80 hands (40 healthy adults) were measured. The WBT was performed in a plastic container filled with water. The probe was placed adjacent to the skin surface without contact. In the DM, sonographic images were obtained with the probe and skin separated by sufficient transmission gel. The muscle thickness and cross-sectional area (CSA) were calculated with both methods. All subjects were examined three times by two examiners to estimate the inter- and intra-observer reliability. Bland-Altman analysis was performed to examine the agreement between the methods. RESULTS: No significant differences in the thickness or CSA of the APB were found. The interclass correlation coefficients for the WBT and DM showed almost perfect intra- and inter-observer reliability (range 0.87-0.94). There was no systematic bias between the techniques in the Bland-Altman analysis. CONCLUSION: Similar to the WBT, the DM provides measurements of the APB thickness and CSA without causing morphometric changes.


Assuntos
Músculo Esquelético/fisiologia , Ultrassonografia/métodos , Adulto , Algoritmos , Feminino , Mãos/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/diagnóstico por imagem , Reprodutibilidade dos Testes , Água , Adulto Jovem
18.
Diagn Cytopathol ; 47(8): 828-830, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31009173

RESUMO

Phaeohyphomycosis is a chronic subcutaneous fungal infection caused by dematiaceous fungi, commonly involving the extremities, which present as single or multiple lesions mimicking a benign tumor. Fine-needle aspiration cytology (FNAC) is an easy method for the diagnosis of the lesion. Morphology of the fungus is characteristic with no difficulty for cytopathologist for identification; with a close differential diagnosis of Candida and Aspergillosis. The special stains like periodic acid schiff (PAS) highlights the fungus and the Masson Fontana confirm the melanin pigment and dematiaceous nature of the fungi. Liquid-based cytology (LBC) preparation of the aspirated material was attempted, which is not usually performed on day to day basis. However, in our case the conventional smears were better for appreciating the fungal morphology.


Assuntos
Mãos/patologia , Biópsia Líquida , Feoifomicose/diagnóstico , Feoifomicose/patologia , Pigmentação , Diagnóstico Diferencial , Fungos , Mãos/diagnóstico por imagem , Mãos/microbiologia , Humanos , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Feoifomicose/diagnóstico por imagem , Feoifomicose/microbiologia
19.
PLoS One ; 14(4): e0215736, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31002697

RESUMO

The present study employed functional magnetic resonance imaging (fMRI) to examine the characteristics of negative blood oxygen level-dependent (Negative BOLD) signals during motor execution. Subjects repeated extension and flexion of one of the following: the right hand, left hand, right ankle, or left ankle. Negative BOLD responses during hand movements were observed in the ipsilateral hemisphere of the hand primary sensorimotor area (SMI), medial frontal gyrus (MeFG), middle frontal gyrus (MFG), and superior frontal gyrus (SFG). Negative BOLD responses during foot movements were also noted in the bilateral hand SMI, MeFG, MFG, SFG, inferior frontal gyrus, middle temporal gyrus, parahippocampal gyrus, anterior cingulate cortex, cingulate gyrus (CG), fusiform gyrus, and precuneus. A conjunction analysis showed that portions of the MeFG and CG involving similar regions to those of the default mode network were commonly deactivated during voluntary movements of the right/left hand or foot. The present results suggest that three mechanisms are involved in the Negative BOLD responses observed during voluntary movements: (1) transcallosal inhibition from the contralateral to ipsilateral hemisphere in the SMI, (2) the deactivated neural network with several brain regions, and (3) the default mode network in the MeFG and CG.


Assuntos
Pé/fisiologia , Giro do Cíngulo/fisiologia , Mãos/fisiologia , Imagem por Ressonância Magnética/métodos , Movimento/fisiologia , Oxigênio/sangue , Adolescente , Adulto , Encéfalo/diagnóstico por imagem , Encéfalo/fisiologia , Mapeamento Encefálico , Feminino , Pé/diagnóstico por imagem , Giro do Cíngulo/diagnóstico por imagem , Mãos/diagnóstico por imagem , Humanos , Masculino , Córtex Sensório-Motor/diagnóstico por imagem , Córtex Sensório-Motor/fisiologia , Adulto Jovem
20.
Biomed Eng Online ; 18(1): 44, 2019 Apr 08.
Artigo em Inglês | MEDLINE | ID: mdl-30961620

RESUMO

BACKGROUND: The usability of dexterous hand prostheses is still hampered by the lack of natural and effective control strategies. A decoding strategy based on the processing of descending efferent neural signals recorded using peripheral neural interfaces could be a solution to such limitation. Unfortunately, this choice is still restrained by the reduced knowledge of the dynamics of human efferent signals recorded from the nerves and associated to hand movements. FINDINGS: To address this issue, in this work we acquired neural efferent activities from healthy subjects performing hand-related tasks using ultrasound-guided microneurography, a minimally invasive technique, which employs needles, inserted percutaneously, to record from nerve fibers. These signals allowed us to identify neural features correlated with force and velocity of finger movements that were used to decode motor intentions. We developed computational models, which confirmed the potential translatability of these results showing how these neural features hold in absence of feedback and when implantable intrafascicular recording, rather than microneurography, is performed. CONCLUSIONS: Our results are a proof of principle that microneurography could be used as a useful tool to assist the development of more effective hand prostheses.


Assuntos
Algoritmos , Mãos/diagnóstico por imagem , Mãos/inervação , Nervo Mediano/fisiologia , Desenho de Prótese/métodos , Feminino , Dedos/diagnóstico por imagem , Dedos/fisiologia , Mãos/fisiologia , Humanos , Masculino , Neurônios Motores/citologia , Movimento , Músculos/fisiologia , Ultrassonografia
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