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1.
Medicine (Baltimore) ; 98(39): e17298, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31574854

RESUMO

Recently, studies have shown significant association between the rs2000999 polymorphism in the haptoglobin-encoding gene (HP) and low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) levels, which are important risk factors for cardiovascular diseases. However, the association of rs2000999 with serum lipids in Latin American diabetic populations is still uncharacterized. Here, we analyzed the association of rs2000999 with TC, high-density lipoprotein cholesterol (HDL-C), and LDL-C levels in 546 Mexican adults with type 2 diabetes (T2D) and in 654 controls without T2D. In this observational case-control study we included adults from 4 centers of the Mexican Social Security Institute in Mexico City recruited from 2012 to 2015. TC, HDL-C, LDL-C, triglycerides (TG), and glucose levels were measured by an enzymatic colorimetric method. The variant rs2000999 was genotyped using TaqMan real time polymerase chain reaction. The percentage of Native-American ancestry showed a negative association with the rs2000999 A allele. In contrast, the rs2000999 A allele had a strong positive association with European ancestry, and to a lesser extent, with African ancestry. Linear regression was used to estimate the association between the variant rs2000999 and lipid concentrations, using different genetic models. Under codominant and recessive models, rs2000999 was significantly associated with TC and LDL-C levels in the T2D group and in controls without T2D. In addition, the group with T2D showed a significant association between the variant and HDL-C levels. In summary, the rs2000999 A allele in Mexican population is positively associated with the percentage of European and negatively associated with Native American ancestry. Carriers of the A allele have increased levels of TC and LDL-C, independently of T2D diagnosis, and also increased concentrations of HDL-C in the T2D sample.


Assuntos
Doenças Cardiovasculares , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Colesterol/sangue , Diabetes Mellitus Tipo 2 , Haptoglobinas , Adulto , Biomarcadores/análise , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/genética , Estudos de Casos e Controles , Diabetes Mellitus Tipo 2/sangue , Diabetes Mellitus Tipo 2/diagnóstico , Diabetes Mellitus Tipo 2/epidemiologia , Diabetes Mellitus Tipo 2/genética , Feminino , Haptoglobinas/análise , Haptoglobinas/genética , Humanos , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único , Fatores de Risco
2.
J Glob Health ; 9(2): 020413, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31448114

RESUMO

Background: Past studies have demonstrated how single non-communicable diseases (NCDs) affect health care utilisation and quality of life (QoL), but not how different NCD combinations interact to affect these. Our study aims to investigate the prevalence of NCD dyad and triad combinations, and the implications of different NCD dyad combinations on health care utilisation and QoL. Methods: Our study utilised cross-sectional data from the WHO SAGE study to examine the most prevalent NCD combinations in six large middle-income countries (MICs). Subjects were mostly aged 50 years and above, with a smaller proportion aged 18 to 49 years. Multivariable linear regression was applied to investigate which NCD dyads increased or decreased health care utilisation and QoL, compared with subjects with only one NCD. Results: The study included 41 557 subjects. Most prevalent NCD combinations differed by subgroups, including age, gender, income, and residence (urban vs rural). Diabetes, stroke, and depression had the largest effect on increasing mean number of outpatient visits, increasing mean number of hospitalisation days, and decreasing mean QoL scores, respectively. Out of the 36 NCD dyads in our study, thirteen, four, and five dyad combinations were associated with higher or lower mean number of outpatient visits, mean number of hospitalisations, or mean QoL scores, respectively, compared with treating separate patients with one NCD each. Dyads of depression were associated with fewer mean outpatient visits, more hospitalisations, and lower mean QoL scores, compared to patients with one NCD. Dyads of hypertension and diabetes were also associated with a reduced mean number of outpatient visits. Conclusions: Certain NCD combinations increase or decrease health care utilisation and QoL substantially more than treating separate patients with one NCD each. Health systems should consider the needs of patients with different multimorbidity patterns to effectively respond to the demands on health care utilisation and to mitigate adverse effects on QoL.


Assuntos
Países em Desenvolvimento , Multimorbidade/tendências , Doenças não Transmissíveis/epidemiologia , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Qualidade de Vida , Adolescente , Adulto , Idoso , China/epidemiologia , Estudos Transversais , Feminino , Gana/epidemiologia , Humanos , Índia/epidemiologia , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Prevalência , Federação Russa/epidemiologia , África do Sul/epidemiologia , Adulto Jovem
4.
BMC Public Health ; 19(1): 1013, 2019 Jul 29.
Artigo em Inglês | MEDLINE | ID: mdl-31357983

RESUMO

BACKGROUND: Social disadvantages that start during childhood and continue into the later stages in life may be linked to the presence of diabetes during adulthood. OBJECTIVE: To analyze whether the presence of social disadvantages in childhood and in the present affects the presence of diabetes in older adults. METHODS: The present study was based on longitudinal data from the third and fourth Mexican Health and Aging Study (MHAS) waves (2012 and 2015). Data on diabetes diagnosis, past (e.g. "no shoes during childhood") and present (e.g. self-perception of economic status) social disparities, and other covariables were analyzed. RESULTS: From 8,848 older adults, 21.5% (n = 1903) were classified as prevalent cases (PG), 5.2% (n = 459) as incident cases (IG) and 77.4% (n = 6,486) were free of disease (NDG). The predictor variable "no shoes during childhood" was statistically significant in the model incident versus no diabetes group. Hypertension and body mass index (BMI) were the most relevant covariates as they were statistically significant in the three groups (PG, IG and NDG). CONCLUSIONS: Not having shoes during childhood, an indicator of social disadvantages, is associated with the incidence and prevalence of diabetes in older adults. This suggests that social disadvantages can be a determinant for the presence of chronic diseases in adulthood.


Assuntos
Experiências Adversas da Infância/estatística & dados numéricos , Diabetes Mellitus/epidemiologia , Pobreza/estatística & dados numéricos , Determinantes Sociais da Saúde , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Estudos Longitudinais , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Fatores de Risco
5.
J Med Microbiol ; 68(9): 1373-1382, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31329097

RESUMO

Introduction. Bacterial vaginosis (BV) is dysbiosis associated with an increased risk of several sexually transmitted infections. It is primarily diagnosed via Gram staining, although molecular analyses have presented higher diagnostic accuracy.Aim. This study aimed to evaluate the molecular epidemiology of BV in asymptomatic women to determine its association with several commensal and pathogenic micro-organisms of the genitalia.Methodology. The prevalence of BV was investigated through semiquantitative assessment of 201 women recruited during their routine gynaecological inspection at an outpatient clinic in Tabasco, Mexico.Results. Women with BV showed an increased prevalence of Chlamydia trachomatis (P=0.021) and Mycoplasma hominis (P=0.001). Of the BV-associated micro-organisms, Gardnerella vaginalis was significantly associated with C. trachomatis (P=0.005) and/or Ureaplasma parvum (P=0.003), whereas Atopobium vaginae and Megasphaera type 1 correlated significantly with Mycoplasma hominis (P=0.001). No significant association was observed between human papillomavirus (HPV) infection and BV, although there was increased prevalence of HPV59, HPV73, HPV52 and HPV58 in women displaying cervical cytological abnormalities.Conclusion. Identification of BV-associated micro-organisms via molecular analysis may help to distinguish recurrent cases from new infections and identify micro-organisms potentially associated with pharmacological resistance.


Assuntos
Bactérias/classificação , Bactérias/isolamento & purificação , Genitália Feminina/microbiologia , Epidemiologia Molecular , Vaginose Bacteriana/epidemiologia , Vaginose Bacteriana/microbiologia , Adolescente , Adulto , Doenças Assintomáticas , Bactérias/genética , Feminino , Genitália Feminina/virologia , Humanos , México/epidemiologia , Pessoa de Meia-Idade , Papillomaviridae/classificação , Papillomaviridae/isolamento & purificação , Prevalência , Adulto Jovem
6.
Medicine (Baltimore) ; 98(27): e16291, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31277162

RESUMO

Despite the worldwide increasing incidence and prevalence of Inflammatory Bowel Disease (IBD), our knowledge about it in Mexico is still limited. The aim of this study is to describe the incidence and prevalence of IBD as well as its clinical and socio-demographical characteristics in Mexico from a nation-wide perspective.Multicenter nation-wide cohort study that included 42 IBD clinics from all over the country that participated with electronically register of the new cases over 17 years as well as all known existing cases together with their clinical and socio-demographical characteristics from patients with IBD (ulcerative colitis [UC], Crohn disease [CD], and inflammatory bowel disease unclassified [IBDU]). The data collection was conducted between January and October 2017. Incidence, prevalence, and mean incidence over 2 decades were then calculated. Data base was analyzed using SPSS v24 program SPSS (version 24, IBM Corp., Armonk, NY, USA).A total of 2645 patients with IBD were registered. The crude incidence rates of IBD, UC, and CD, respectively, were 0.21, 0.16, and 0.04 cases per 100,000-person year. The highest incidence was registered in the year 2015, compared with to the previous years. The mean incidence of IBD has increased steadily from 0.05 to 0.21 per 100,000 person-years over the past 15 years (P = .06). The incidence of IBD new cases have increased significantly throughout the last 16 years, 5.9-fold for IBD, 5.3-fold for UC, and 9.5-fold for CD. The prevalence rates of IBD, UC, and CD, respectively, were 1.83, 1.45, and 0.34 cases per 100,000-person-year.This is the first study from a nation-wide perspective that demonstrated a significant increase of prevalence and incidence of IBD in Mexico in the last 15 years.


Assuntos
Previsões , Doenças Inflamatórias Intestinais/epidemiologia , Vigilância da População , Adolescente , Adulto , Bases de Dados Factuais , Feminino , Seguimentos , Humanos , Incidência , Masculino , México/epidemiologia , Prevalência , Estudos Retrospectivos , Adulto Jovem
7.
Parasit Vectors ; 12(1): 277, 2019 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-31151478

RESUMO

BACKGROUND: We assessed metrics of the metazoan parasite infracommunities of the dusky flounder (Syacium papillosum) as indicators of aquatic environmental health of the Yucatan Shelf (YS) prior to oil extraction. We sampled the dusky flounder and its parasites along the YS, mostly during the 2015 north wind season (November-April). Our aims were: (i) to determine whether the parasite infracommunity metrics of S. papillosum exhibit significant differences among YS subregions; (ii) to determine whether the probability of the occurrence of its parasite species and individuals were affected by environmental variables, nutrients, heavy metals and hydrocarbons at the seascape level; and (iii) to determine whether there were statistical differences between the parasite infracommunity metrics of S. papillosum from YS and those of Syacium gunteri from the Campeche Sound. Multivariate statistical analyses and generalised additive models (GAMs) were used to examine the potential statistical associations between the contaminants, environmental variables and parasite community metrics, and the maximum entropy algorithm (MaxEnt) was used to characterise the habitat's suitability for the parasite's probability of occurrence. RESULTS: We recovered 48 metazoan parasite species from 127 S. papillosum, with larval cestodes and digeneans being the most numerically-dominant. Multivariate analyses showed significant differences in parasite infracommunity metrics among Western YS, Mid YS and Caribbean subregions, with the latter being the richest in species but not in individuals. The GAM and MaxEnt results indicated a negative effect of top predators (e.g. sharks and rays) removal on parasite metrics. The parasite infracommunities of S. papillosum were twice as rich in the number of species and individuals as those reported for S. gunteri from the Campeche Sound. CONCLUSIONS: The significant differences among subregions in parasite metrics were apparently due to the interruption of the Yucatan current during the north wind season. The fishing of top predators in combination with an influx of nutrients and hydrocarbons in low concentrations coincides with an increase in larval cestodes and digeneans in S. papillosum. The dusky flounder inhabits a region (YS) with a larger number of metazoan parasite species compared with those available for S. gunteri in the Campeche Sound, suggesting better environmental conditions for transmission in the YS.


Assuntos
Biomarcadores Ambientais , Doenças dos Peixes/parasitologia , Linguado/parasitologia , Parasitos/isolamento & purificação , Animais , Biota , Doenças dos Peixes/epidemiologia , México/epidemiologia , Análise Multivariada , Parasitos/classificação
8.
An. psicol ; 35(2): 314-322, mayo 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-181704

RESUMO

El Athlete Burnout Questionnaire (ABQ) se ha convertido en el instrumento más utilizado para evaluar el burnout en el contexto deportivo, lo que ha permitido un incremento significativo en las investigaciones. A pesar de ello, una revisión en la literatura revela que no existen trabajos que proporcionen datos psicométricos del ABQ con muestra mexicana, por lo que el objetivo de la presente investigación fue analizar las propiedades psicométricas del Athlete Burnout Questionnaire en deportistas mexicanos. El análisis de los datos se desarrolló a través de 2 estudios, aplicando el cuestionario en el primero de ellos a una muestra de 464 jóvenes deportistas entre 13 y 18 años de edad (M = 14.85, DT = 1.45). Los resultados del Análisis Factorial Confirmatorio (AFC) indicaron índices de ajuste aceptables (c2 = 176.7; c2 /gl = 2.18; p < .01; TLI = .93, IFI = .95, CFI = .95 y RMSEA = .05) así como pesos de regresión aceptables para la estructura trifactorial del cuestionario original. Para el segundo estudio se utilizó una muestra de 1009 deportistas mexicanos entre 12 y 39 años de edad (M = 17.28, DT = 2.98). Los resultados del AFC encontraron suficiente evidencia para la validez de constructo (c2 = 419.5; c2 /gl = 5.59; p < .01; TLI = .94, IFI = .96, CFI = .96 y RMSEA = .07). Los resultados en el análisis de correlación entre el Athlete Burnout Questionnaire (ABQ) y el Athlete Engagement Questionnaire (AEQ) pueden considerarse como prueba favorable de la validez discriminante. En cuanto a la fiabilidad, se encontraron resultados aceptables en consistencia interna en ambas fases del estudio, concluyendo que el ABQ es una herramienta útil para evaluar el burnout en depotistas mexicanos


The Athlete Burnout Questionnaire (ABQ) has become one of the most used tools to assess burnout in sport contexts. Despite a significant increase in research in this field, the literature has shown that there are no papers which provide psychometric data of the ABQ using a Mexican sample. Hence the objective of the present study was to analyze the psychometric properties of the Athlete Burnout Questionnaire of Mexican athletes. Data analysis was obtained using two studies. The first study consisted of 464 young athletes between 13 and 18 years old (M = 14.85, DT = 1.45). The results of the Confirmatory Factor Analysis (CFA) showed acceptable fit indices (c2 = 176.7; c2 /gl = 2.18; p < .01; TLI = .93, IFI = .95, CFI = .95 y RMSEA = .05) Acceptable results of load regression were also found for the original three factor questionnaire. A sample of 1009 Mexican athletes between 12 and 39 years of age (M = 17.28, SD = 2.98) were used for the second study. The results of the CFA found sufficient evidence for the construct validity (c2 = 419.5; 2cc2 /gl = 5.59; p < .01; TLI = .94, IFIS = .96, CFI = .96 and RMSEA = .07). The results in the analysis of correlation between the Athlete Burnout Questionnaire (ABQ) and the Athlete Engagement questionnaire (AEQ) can be considered as evidence of the discriminant validity. In regard to reliability, acceptable results were observed in internal consistency in both phases of the study, concluding that the ABQ is a useful tool to evaluate the burnout in Mexican athletes


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Adulto Jovem , Adulto , Psicometria/instrumentação , Esgotamento Profissional/psicologia , Atletas/psicologia , Logro , Desempenho Atlético/psicologia , Reprodutibilidade dos Testes , México/epidemiologia , Esportes/psicologia
9.
J Stroke Cerebrovasc Dis ; 28(8): 2109-2114, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31133484

RESUMO

BACKGROUND: Overall, 75.2% of deaths from stroke occur in low- and middle-income countries. Mexico is a middle-income country with little information about the prognosis of early and late postischemic and hemorrhagic stroke. OBJECTIVE: To evaluate the factors associated with post-stroke survival in the Mexican population. METHODS: Observational study of consecutive stroke cases involving a first-ever hemorrhagic or ischemic stroke, with patients who received care at the National Institute of Neurology and Neurosurgery, in Mexico City, between 2009 and 2012. Patients were followed for up to 4 years after the index event. Exploratory analysis of survival was carried out with Kaplan-Meier and log-rank tests. Factors associated with survival time were determined using Cox models. RESULTS: A total of 300 out of 544 (55.15%) patients had a hemorrhagic stroke, 135 of 544 (24.82%) patients died during the entire follow-up period, and 56 of 544 (10.29%) died in the first 30 days post-stroke (early mortality). Early mortality after stroke was associated with age ≥ 65 years (Adjusted Hazard Ratio - AHR = 2.07, P = .02) and ≥ 2 in-hospital medical complications (AHR = 46.13, P < .01). Late mortality was associated with age ≥ 65 years (AHR = 3.43, P < .01), ≥2 in-hospital medical complications (AHR = 2.55, P < .01), high comorbidity (AHR = 5.43, P < .01), and recurrence (AHR = 1.90, P = .01). CONCLUSIONS: Patients with hemorrhagic and ischemic stroke who presented in-hospital medical complications, high comorbidity, and were over 65 years old had higher rates of early and late mortality.


Assuntos
Isquemia Encefálica/mortalidade , Isquemia Encefálica/terapia , Hemorragias Intracranianas/mortalidade , Hemorragias Intracranianas/terapia , Acidente Vascular Cerebral/mortalidade , Acidente Vascular Cerebral/terapia , Adulto , Fatores Etários , Idoso , Isquemia Encefálica/diagnóstico , Comorbidade , Feminino , Seguimentos , Humanos , Hemorragias Intracranianas/diagnóstico , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Acidente Vascular Cerebral/diagnóstico , Análise de Sobrevida , Fatores de Tempo , Resultado do Tratamento
10.
Int J Food Microbiol ; 304: 1-10, 2019 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-31146052

RESUMO

Water contamination by pathogenic bacteria is a global public health problem. Contamination of surface water utilized to irrigate food products, or for human consumption, causes outbreaks of foodborne and waterborne disease. Of these, those caused by diarrheagenic Escherichia coli (DEC) strains present substantial morbidity and mortality. The aim of this study was, therefore, to investigate the microbiological quality of surface water and the presence of DEC strains in different water bodies. A total of 472 water samples were collected from irrigation canal, dam, river, and dike water bodies from January through December 2015 in Sinaloa, a State located in Northwestern Mexico. Our studies demonstrated that 47.0% (222/472) of samples contained thermotolerant coliforms above permissive levels whereas E. coli strains were isolated from 43.6% (206/472). Among these E. coli isolates, DEC strains were identified in 14% (29/206) of samples including in irrigation canal (26/29) and river water (3/29) collected from the northern (83%) and central area (17%). Isolated DEC strains were classified as enteroaggregative E. coli (EAEC) 34.4% (10/29), enteropathogenic E. coli (EPEC) 31.0% (9/29), diffuse adherent E. coli (DAEC) 27.5% (8/29), and enterotoxigenic E. coli (ETEC) 6.8% (2/29). Moreover, 90% of isolated DEC strains exhibited resistance to at least one commonly prescribed antibiotic in Mexico whereas 17% were multi-drug resistant. In conclusion, the presence of DEC strains in surface water represents a potential source for human infection, and thus routine monitoring of DEC in surface water and other indirect affected areas should be considered at northwestern Mexico.


Assuntos
Irrigação Agrícola/métodos , Escherichia coli Enteropatogênica/isolamento & purificação , Escherichia coli Enterotoxigênica/isolamento & purificação , Rios/microbiologia , Qualidade da Água , Antibacterianos/farmacologia , Diarreia/microbiologia , Farmacorresistência Bacteriana Múltipla , Escherichia coli Enteropatogênica/efeitos dos fármacos , Escherichia coli Enterotoxigênica/efeitos dos fármacos , Infecções por Escherichia coli/epidemiologia , Infecções por Escherichia coli/microbiologia , Doenças Transmitidas por Alimentos/microbiologia , Humanos , México/epidemiologia , Água , Microbiologia da Água , Doenças Transmitidas pela Água/microbiologia
11.
Traffic Inj Prev ; 20(3): 303-307, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30971147

RESUMO

Objective: The objective of this study was to identify pedestrian risk behaviors that result in traffic accidents and characterization of the accidents experienced by participants in this study to provide information for the generation of integral preventive strategies. Methods: The study was correlational, descriptive, and transversal and followed a quantitative approach divided into 2 stages. In the first stage, an observational study was performed to identify the manifested risk behaviors of pedestrians, which served as a basis for the construction and design of a questionnaire. In the second stage, the questionnaire was applied to a group of 1,536 participants. Pearson's correlation coefficient was applied to establish associations between gender and age with respect to risk behaviors. Results: The 3 behaviors that participants reported performing always or very often include using electronic gadgets (except mobile phones), not using a pedestrian crosswalk, and using a mobile phone. In addition, 18.5% were involved in at least one road accident as a pedestrian in the last 5 years. Of the total number of registered accidents, 21% resulted in pedestrian injuries, 48.3% of which were serious. These were due to external causes not related to human factors or unidentified (58.5%) and behavior factors as a whole (41.4%, 31.5% of which were caused by pedestrians). Pearson's correlation coefficient showed evidence of a correlation between age and risk behaviors. Conclusions: All subjects in this study performed several risky actions as pedestrians, at least occasionally, and at least one fifth had been involved in a road accident as a pedestrian. It is known that the surroundings can positively or negatively influence individuals' behaviors; therefore, once prevention measures are identified, it is possible to influence risk behaviors. Therefore, road safety education and the physical environment must be considered together, and efforts focused on optimum infrastructure also need to consider road safety education.


Assuntos
Acidentes de Trânsito/estatística & dados numéricos , Pedestres/psicologia , Assunção de Riscos , Adolescente , Adulto , Telefone Celular/estatística & dados numéricos , Feminino , Humanos , Masculino , México/epidemiologia , Pessoa de Meia-Idade , Pedestres/estatística & dados numéricos , Inquéritos e Questionários , Ferimentos e Lesões/epidemiologia
12.
Turk Neurosurg ; 29(3): 317-322, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30984992

RESUMO

Every year, natural or people-generated disasters disrupt the functioning of society, causing human, and material loses, which lead to an increase in the demand for medical attention. In the morning of September 19, 2017, a 7.1-magnitude earthquake struck Mexico City and four other cities, leaving around 19 million people affected and 331 dead. Although the medical response was timely, most of the efforts fell short because demand exceeded responsiveness. This incident evidenced the challenges that we have as caregivers with mass medical emergency, and the need for direct and well-structured interventions of professional-medical associations in the immediate response, on both in-site and in-hospital settings. The aim of this paper is to analyze how we respond to these medical emergencies and what new strategies have been proposed in order to identify the weaknesses and areas of improvement, as well as to restructure our methods of emergency intervention. We searched all the information in both official institutional and social media with a public sanitary scope. We submitted this information to a descriptive qualitative analysis and compared with official information and management. We found an important role for social media as a means of communication and civil organization. Collegiate medical societies, such as neurosurgeons, showed a limited reach, little on-site intervention, and poor use of social media and other strategies to improve the response. Finally, we propose how we may approach these mass medical emergencies in a better way, taking advantage of new technologies and strategies.


Assuntos
Desastres , Terremotos , Emergências/epidemiologia , Procedimentos Neurocirúrgicos/tendências , Socorristas , Humanos , México/epidemiologia , Neurocirurgia , Procedimentos Neurocirúrgicos/métodos
13.
Transbound Emerg Dis ; 66(4): 1436-1441, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30941894

RESUMO

Porcine deltacoronavirus has caused great economic losses in the swine industry worldwide. In this study, we carried out the first detection, sequencing and characterization of this virus in Mexico. We analysed 885 rectal samples by multiplex RT-PCR to determine coinfections. In addition, the Spike gene was amplified, sequenced and analysed phylogenetically. We found 85 positive samples for porcine deltacoronavirus, representing 9.6% of the total samples, and we determined that the most frequent coinfection was with porcine epidemic diarrhoea virus (54.1%). Four sequences of Mexican isolates were most closely related to those of the United States. The antigenic regions and the glycosylation site of the strains obtained coincide with those previously reported. This relationship is probably related to the commercial exchange of pigs between the US and Mexico and the geographical proximity of these two countries.


Assuntos
Infecções por Coronavirus/veterinária , Vírus da Diarreia Epidêmica Suína/isolamento & purificação , Glicoproteína da Espícula de Coronavírus/análise , Doenças dos Suínos/epidemiologia , Animais , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/virologia , México/epidemiologia , Vírus da Diarreia Epidêmica Suína/genética , Prevalência , Suínos , Doenças dos Suínos/virologia
14.
BMC Ophthalmol ; 19(1): 91, 2019 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-30987639

RESUMO

BACKGROUND: Retinopathy of prematurity (ROP), the primary cause of blindness in children, is a potential complication for 7.7% of live births in Mexico. Given that less than one-third of all neonatal intensive care units follow Mexican National ROP guidelines, there have been few reports regarding the incidences of types 1 and 2 ROP. METHODS: This was a retrospective study that investigated the incidence and onset of ROP in a representative sample of children in Mexico. We analyzed the results obtained by the ROP Detection and Treatment Program, compliant with the Mexican National ROP guidelines, over a 1-year period. This study included 132 children who were born prematurely, were initially screened between October 2, 2017 and October 1, 2018, and underwent follow-up based on their risk group (in accordance with the Mexican National ROP guidelines). RESULTS: The mean gestational age (GA) at birth was 32 weeks and 3 days (32w3d) (95% CI, ± 3 days), and the mean birth weight (BW) was 1594 g (95% CI, ± 96 g). The clinical features were as follows: 36.4% had immature retina without ROP, 22.0% had mild ROP, 5.3% had type 2 ROP, 27.3% had type 1 ROP, and 1.5% had advanced disease. Premature children with ROP requiring treatment (i.e., type 1 ROP + advanced ROP) were born at an MGA of 30w4d (95% CI, ± 5d; range, 26-35 weeks); their MBW was 1316 g (95% CI, ± 110 g; range, 830-2220 g). Diagnosis of ROP requiring treatment was made at a mean postmenstrual age (PMA) of 37w3d (95% CI, ± 5d; range, 31w1d to 42w1d). CONCLUSION: In Mexico, screening and close ophthalmological follow-up of children who present with risk factors of birth weight < 1750 g and gestational age ≤ 34 weeks, both of which are observed more frequently in children with type 1 ROP, appears essential for implementing timely treatments (within 72 h). This is particularly important for children with PMA between 36 and 38 weeks, which is considered to be the peak age for disease stages that require timely intervention.


Assuntos
Triagem Neonatal/métodos , Retinopatia da Prematuridade/epidemiologia , Feminino , Seguimentos , Idade Gestacional , Humanos , Incidência , Recém-Nascido , Masculino , México/epidemiologia , Estudos Retrospectivos , Fatores de Risco
15.
PLoS Negl Trop Dis ; 13(4): e0006859, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30964871

RESUMO

BACKGROUND: In Mexico, estimates of Chagas disease prevalence and burden vary widely. Updating surveillance data is therefore an important priority to ensure that Chagas disease does not remain a barrier to the development of Mexico's most vulnerable populations. METHODOLOGY/PRINCIPAL FINDINGS: The aim of this systematic review and meta-analysis was to analyze the literature on epidemiological surveys to estimate Chagas disease prevalence and burden in Mexico, during the period 2006 to 2017. A total of 2,764 articles were screened and 36 were retained for the final analysis. Epidemiological surveys have been performed in most of Mexico, but with variable study scale and geographic coverage. Based on studies reporting confirmed cases (i.e. using at least 2 serological tests), and taking into account the differences in sample sizes, the national estimated seroprevalence of Trypanosoma cruzi infection was 3.38% [95%CI 2.59-4.16], suggesting that there are 4.06 million cases in Mexico. Studies focused on pregnant women, which may transmit the parasite to their newborn during pregnancy, reported an estimated seroprevalence of 2.21% [95%CI 1.46-2.96], suggesting that there are 50,675 births from T. cruzi infected pregnant women per year, and 3,193 cases of congenitally infected newborns per year. Children under 18 years had an estimated seropositivity rate of 1.51% [95%CI 0.77-2.25], which indicate ongoing transmission. Cases of T. cruzi infection in blood donors have also been reported in most states, with a national estimated seroprevalence of 0.55% [95%CI 0.43-0.66]. CONCLUSIONS/SIGNIFICANCE: Our analysis suggests a disease burden for T. cruzi infection higher than previously recognized, highlighting the urgency of establishing Chagas disease surveillance and control as a key national public health priority in Mexico, to ensure that it does not remain a major barrier to the economic and social development of the country's most vulnerable populations.


Assuntos
Doença de Chagas/epidemiologia , Trypanosoma cruzi , Adolescente , Adulto , Doadores de Sangue/estatística & dados numéricos , Doença de Chagas/sangue , Doença de Chagas/transmissão , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Transmissão Vertical de Doença Infecciosa , México/epidemiologia , Gravidez , Prevalência , Estudos Soroepidemiológicos , Testes Sorológicos/estatística & dados numéricos
16.
Actas esp. psiquiatr ; 47(2): 45-53, mar.-abr. 2019. tab
Artigo em Espanhol | IBECS | ID: ibc-181339

RESUMO

Introducción. La prevalencia del Trastorno de Déficit de atención e hiperactividad TDHA en población infantil varia debido a la metodología empleada, en México el sector salud reconoce dificultades para medirla y tratarla, asi la OMS recomienda realizar cribados en poblaciones con probabilidad de presentarla. El objetivo fue medir la prevalencia de TDAH con propósitos de cribado en escolares de segundo grado, su comorbilidad, y describir la experiencia utilizando la versión 3 de la escala de Conners. Método. Estudio observacional descriptivo, con propósito de cribado aplicando las versiones cortas a padres y maestros de 3,985 escolares en una muestra de 55 escuelas publicas obtenidas al azar de dos delegaciones en la Ciudad de México, los casos fueron referidos a psicología y Psiquiatría para corroborar diagnostico y tratamiento. Resultados. Se detectaron 458(16%) casos, por ambos informantes, el subtipo prevalente fue hiperactivo en ambos sexos con predominio masculino, los problemas de aprendizaje y funciones ejecutivas mas frecuentes en niñas con subtipos hiperactivo y combinado, solo completaron la evaluación psicológica 150 escolares y 127 acudieron con el paidopsiquiatra, quien confirmo 72% de los casos. Conclusiones. La prevalencia con fines de cribado, subtipo de TDAH y genero afectado es semejante a la reportada en la literatura, la comorbilidad identificada por ambos informantes es una ventaja que ofrece la escala Conners 3, la limitante para corroborar el diagnostico fue la resistencia de los padres para acudir con los especialistas. Es necesario orientar e informar mas a los padres sobre el trastorno para lograr una mejor participación


Introduction. The prevalence of Attention Deficit Hyperactivity Disorder (ADHD) in children varies due to the methodology used. In Mexico, the health sector recognizes difficulties in measuring and treating it, so the WHO recommends carrying out screening in populations with a probability of presenting it. The objective was to measure the prevalence of ADHD for screening purposes in second-grade students, their comorbidity, and to describe the experience using version 3 of the Conners scale. Method. Descriptive observational study, with the purpose of screening, applying the short versions to parents and teachers of 3,985 schoolchildren in a sample of 55 public schools obtained at random from two delegations in Mexico City, the cases were referred to psychology and psychiatry to corroborate diagnosis and treatment. Results We detected 458 (16%) cases, both informants, the prevalent subtype was hyperactive in both sexes, predominantly male, learning problems and executive functions more frequent in girls with hyperactive and combined subtype, only completed the psychological evaluation 150 schoolchildren and 127 attended with the paidopsiquiatra, who confirmed 72% of the cases. Conclusions. The prevalence for screening purposes, subtype of ADHD and affected gender is similar to that reported in the literature, the comorbidity identified by both informants is an advantage offered by the Conners scale 3, the limiting factor to corroborate the diagnosis was the resistance of the parents to go with the specialists. It is necessary to guide and inform parents more about the disorder to achieve better participation


Assuntos
Humanos , Masculino , Feminino , Criança , Estudantes/psicologia , Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia , Ensino Fundamental e Médio , México/epidemiologia , Transtorno do Deficit de Atenção com Hiperatividade/psicologia , Comorbidade , Epidemiologia Descritiva , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Estudos Transversais , Inquéritos e Questionários
17.
Rev. neurol. (Ed. impr.) ; 68(8): 321-325, 16 abr., 2019. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-180665

RESUMO

Introducción. El descontrol de la epilepsia representa un potencial daño neurológico, por lo que deben investigarse sus causas. Objetivo. Explorar la epidemiología de pacientes mexicanos con descontrol agudo de epilepsia en un servicio de urgencias neurológicas. Pacientes y métodos. Análisis prospectivo descriptivo de pacientes con diagnóstico previo de epilepsia que acuden a un servicio de urgencias por descontrol de las crisis. Resultados. Se analizó a 100 pacientes entre agosto de 2016 y enero de 2017. Ochenta y seis fueron crisis focales, de las cuales 76 fueron focales a bilaterales tonicoclónicas, dos fueron con alteración de la consciencia de inicio motor y tres de inicio no motor, una sin alteración de la consciencia de inicio motor y cuatro de inicio no motor. Catorce fueron generalizadas de inicio generalizado motor. Las causas de descontrol fueron: 26 pacientes por falta de adhesión al tratamiento antiepiléptico, 21 de causa desconocida, 19 por infección, 13 por privación de sueño, 10 por ajuste de tratamiento, tres por estrés, tres por menstruación, dos por uso de alcohol y tres por otras razones. En los 26 pacientes con falta de adhesión, 10 fueron por olvido de dosis, siete por negarse a tomar el medicamento, seis por causas económicas y tres por indicación de médico ajeno a la institución. Conclusiones. En México, la falta de adhesión al tratamiento representa un 25% de los casos de descontrol de la epilepsia, lo que es un área de oportunidad para incrementar la educación de higiene de crisis y disminuir la frecuencia de éstas


Introduction. Acute seizures in patients with epilepsy are a potential of source of neurological damage; their causes must be researched. Aim. To explore the epidemiology of acute seizure exacerbations in patients with epilepsy in a neurological emergency department in Mexico City. Patients and methods. Descriptive prospective study of patients with a previous diagnosis of epilepsy that receive medical care in an emergency department due to acute seizures. Results. 100 patients were analyzed between august 2016 and January 2017. 86 patients presented with focal seizures, of which 76 were focal to bilateral tonic-clonic, 2 with impaired awareness and motor onset, 3 with impaired awareness and non-motor onset, 1 without impaired awareness and motor onset, and 4 without impaired awareness and non-motor onset. 14 patients had generalized seizures with motor onset. The causes of exacerbation were as follows: 26 patients due to antiepileptic dose omission, 21 due to a unknown cause, 19 due to infection, 13 due to sleep deprivation, 3 due to stress, 3 were catamenial, 2 due to alcohol abuse and 3 due to other reasons. Of the 26 patients with dose omission, 10 were due to forgetfulness, 7 refused to comply with their prescription, 6 could not afford to buy their prescription and 3 had their prescription changed by another doctor. Conclusions. In Mexico, antiepileptic drug dose omission represents up to 25% of patients with acute seizure exacerbations; increased patient education on epilepsy hygiene measures may be an area of opportunity for reducing its frequency


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Serviços Médicos de Emergência , Epilepsia , Estudos Prospectivos , México/epidemiologia , Epilepsia/epidemiologia , Epilepsia/tratamento farmacológico , Epilepsia/etiologia
18.
Clin Appl Thromb Hemost ; 25: 1076029619841700, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30968703

RESUMO

The sticky platelet syndrome (SPS) is a common cause of both arterial and venous thrombosis, being a dominant autosomal disease with qualitative platelet alterations and familial occurrence. It is characterized by platelet hyperreactivity with increased platelet aggregability in response to low concentrations of platelet agonists: epinephrine, adenosine diphosphate, or both. The clinical manifestations involve venous or arterial thrombosis, recurrent pregnancy loss, and fetal growth retardation. To analyze the localization of the thrombotic episodes in a cohort of Mexican mestizo patients with SPS. Between 1992 and 2016, 86 Mexican mestizo patients with SPS as the single thrombophilic condition were prospectively identified; all of them had a history of thrombosis. There were 15 males and 71 females. The thrombotic episodes were arterial in 26 cases and venous in 60 (70%). Arterial thrombosis was mainly pulmonary thromboembolism, whereas venous thromboses were identified most frequently in the lower limbs. Mexican mestizo population with SPS is mainly female; the type I of the condition is the most frequent; both arterial and venous thrombosis can occur, and they are mainly pulmonary embolism and lower limbs venous thrombosis, respectively.


Assuntos
Transtornos Plaquetários/sangue , Trombofilia/sangue , Trombose Venosa/sangue , Adulto , Transtornos Plaquetários/epidemiologia , Transtornos Plaquetários/etnologia , Feminino , Humanos , Masculino , México/epidemiologia , México/etnologia , Estudos Retrospectivos , Síndrome , Trombofilia/epidemiologia , Trombofilia/etnologia , Trombose Venosa/epidemiologia , Trombose Venosa/etnologia
19.
Actas Esp Psiquiatr ; 47(2): 45-53, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31017272

RESUMO

INTRODUCTION: The prevalence of Attention Deficit Hyperactivity Disorder (ADHD) in children varies due to the methodology used. In Mexico, the health sector recognizes difficulties in measuring and treating it, so the WHO recommends carrying out screening in populations with a probability of presenting it. The objective was to measure the prevalence of ADHD for screening purposes in second-grade students, their comorbidity, and to describe the experience using version 3 of the Conners scale. METHOD: Descriptive observational study, with the purpose of screening, applying the short versions to parents and teachers of 3,985 schoolchildren in a sample of 55 public schools obtained at random from two delegations in Mexico City, the cases were referred to psychology and psychiatry to corroborate diagnosis and treatment. Results We detected 458 (16%) cases, both informants, the prevalent subtype was hyperactive in both sexes, predominantly male, learning problems and executive functions more frequent in girls with hyperactive and combined subtype, only completed the psychological evaluation 150 schoolchildren and 127 attended with the paidopsiquiatra, who confirmed 72% of the cases. CONCLUSIONS: The prevalence for screening purposes, subtype of ADHD and affected gender is similar to that reported in the literature, the comorbidity identified by both informants is an advantage offered by the Conners scale 3, the limiting factor to corroborate the diagnosis was the resistance of the parents to go with the specialists. It is necessary to guide and inform parents more about the disorder to achieve better participation.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/epidemiologia , Programas de Rastreamento/métodos , Estudantes/psicologia , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Criança , Comorbidade , Feminino , Nível de Saúde , Humanos , Masculino , México/epidemiologia , Escalas de Graduação Psiquiátrica , Instituições Acadêmicas , Distribuição por Sexo , Inquéritos e Questionários
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