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2.
Int J Sports Med ; 41(1): 36-43, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31747699

RESUMO

Subconcussive head impacts (SHI), defined as impacts to the cranium that do not result in concussion symptoms, are gaining traction as a major public health concern. The contribution of physiological factors such as physical exertion and muscle damage to SHI-dependent changes in neurological measures remains unknown. A prospective longitudinal study examined the association between physiological factors and SHI kinematics in 15 high school American football players over one season. Players wore a sensor-installed mouthguard for all practices and games, recording frequency and magnitude of all head impacts. Serum samples were collected at 12 time points (pre-season, pre- and post-game for five in-season games, and post-season) and were assessed for an isoenzyme of creatine kinase (CK-MM) primarily found in skeletal muscle. Physical exertion was estimated in the form of excess post-exercise oxygen consumption (EPOC) from heart rate data captured during the five games. Mixed-effect regression models indicated that head impact kinematics were significantly and positively associated with change in CK-MM but not EPOC. There was a significant and positive association between CK-MM and EPOC. These data suggest that when examining SHI, effects of skeletal muscle damage should be considered when using outcome measures that may have an interaction with muscle damage.


Assuntos
Futebol Americano/lesões , Cabeça/fisiopatologia , Músculo Esquelético/lesões , Esforço Físico/fisiologia , Adolescente , Fenômenos Biomecânicos , Concussão Encefálica/fisiopatologia , Creatina Quinase Forma MM/sangue , Futebol Americano/fisiologia , Humanos , Estudos Longitudinais , Masculino , Músculo Esquelético/enzimologia , Consumo de Oxigênio/fisiologia , Estudos Prospectivos , Estados Unidos
3.
Bone Joint J ; 101-B(12): 1498-1505, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31787001

RESUMO

AIMS: The aim of this study was to investigate the difference in functional outcome after repair and non-repair of the pronator quadratus muscle in patients undergoing surgical treatment for a distal radial fracture with volar plating. PATIENTS AND METHODS: A total of 72 patients with a distal radial fracture were included in this randomized clinical trial. They were allocated to have the pronator quadratus muscle repaired or not, after volar locked plating of a distal radial fracture. The patients, the assessor, the primary investigator, and the statistician were blinded to the allocation. Randomization was irreversibly performed using a web application that guaranteed a secure and tamper-free assignment. The primary outcome measure was the Patient Rated Wrist Evaluation (PRWE) after 12 months. Secondary outcomes included the Disabilities of the Arm, Shoulder and Hand (DASH) score, pronation strength, grip strength, the range of pronation and supination, complications, and the operating time. RESULTS: Of the 72 patients, 63 (87.5%) completed follow-up for the primary outcome measure: 31 (86.1%) from the non-repair group and 32 (88.9%) from the repair group. At the 12-month follow-up, the mean difference in PRWE of 5.47 (95% confidence interval (CI) -4.02 to 14.96) between the repair (mean 18.38 (95% CI 10.34 to 26.41)) and non-repair group (mean 12.90 (95% CI 7.55 to 18.25)) was not statistically significant (p = 0.253). There was a statistically significant difference between pronation strength, favouring non-repair. We found no difference in the other secondary outcomes. CONCLUSION: We found that repairing pronator quadratus made no difference to the clinical outcome, 12 months after volar plating of a distal radial fracture. We conclude that there is no functional advantage in repairing this muscle under these circumstances and advise against it. Cite this article: Bone Joint J 2019;101-B:1498-1505.


Assuntos
Placas Ósseas , Fixação Interna de Fraturas/métodos , Músculo Esquelético/cirurgia , Fraturas do Rádio/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Método Duplo-Cego , Feminino , Seguimentos , Fixação Interna de Fraturas/instrumentação , Indicadores Básicos de Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Força Muscular/fisiologia , Músculo Esquelético/lesões , Músculo Esquelético/fisiologia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/prevenção & controle , Pronação/fisiologia , Recuperação de Função Fisiológica , Resultado do Tratamento
4.
J Shoulder Elbow Surg ; 28(10): 2007-2016, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31540726

RESUMO

BACKGROUND: The purpose of this study was to evaluate the different treatment strategies for posterolateral and posteromedial elbow dislocation. METHODS: The study enrolled 21 patients with unstable simple elbow dislocation including 16 cases of posterolateral dislocation (PLDL) and 5 cases of posteromedial dislocation (PMDL). In patients with PLDL, the medial side was evaluated and repaired first, followed by the lateral side. In patients with PMDL, the lateral side was repaired first, followed by the medial side according to residual instability. RESULTS: Among the 16 cases of unstable PLDL, 7 of 9 presenting with complex combined tear of the ulnar collateral ligament (UCL) and flexor muscle on magnetic resonance imaging showed abnormality on valgus stress testing and UCL repair. Three of 7 cases required additional lateral collateral ligament complex (LCLC) repair. Two of 9 cases showing medial complex dual lesions had normal findings on valgus stress testing and were treated only with LCLC repair. Seven of 16 cases without medial complex dual lesion had normal findings on valgus stress testing, and only LCLC repair was performed. All 5 cases of unstable PMDL showed distraction-type LCLC injury on magnetic resonance imaging and required no additional UCL repair after LCLC repair. There were no cases of recurrent instability following this treatment algorithm. CONCLUSIONS: In unstable elbow dislocation, PLDL and PMDL are caused by different mechanisms following damage to different structures. Therefore, different strategies are needed to ameliorate the dislocation and instability.


Assuntos
Ligamento Colateral Ulnar/cirurgia , Articulação do Cotovelo/cirurgia , Luxações Articulares/cirurgia , Instabilidade Articular/cirurgia , Adulto , Algoritmos , Ligamento Colateral Ulnar/diagnóstico por imagem , Ligamento Colateral Ulnar/lesões , Articulação do Cotovelo/diagnóstico por imagem , Feminino , Humanos , Luxações Articulares/diagnóstico por imagem , Instabilidade Articular/diagnóstico por imagem , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/diagnóstico por imagem , Músculo Esquelético/lesões , Reoperação , Adulto Jovem
5.
Rehabilitación (Madr., Ed. impr.) ; 53(3): 214-218, jul.-sept. 2019. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-185559

RESUMO

Las lesiones musculares son frecuentes en el ámbito laboral. Se producen por el mecanismo de traumatismos directos o indirectos bruscos, que ocasiona una rotura de sus fibras, provocando hematomas. Actualmente no existe un modelo único protocolizado de tratamiento. Presentamos el caso de un paciente diagnosticado de rotura muscular completa del delgado plantar por mecanismo traumático indirecto (elongación muscular brusca), con hematoma asociado de gran volumen. Se realizó estudio clínico mediante ecografía, resonancia magnética (RM), escala visual analógica (EVA) para valoración del dolor al inicio y al finalizar el tratamiento (3 semanas), así como la duración de su incapacidad laboral. Recibió terapia con ondas de choque electromagnéticas focales (OCEF) según protocolo. Al finalizar el tratamiento se objetivó una desaparición del hematoma y no hubo complicaciones. Las OCEF pudieran ser una alternativa terapéutica complementaria al tratamiento convencional en esta afección, no obstante, sería necesario proseguir la investigación incluyendo un mayor número de pacientes, y a través de estudios aleatorizados con grupo control


Muscle injuries are frequent in the workplace. They are produced by sudden direct or indirect trauma that involves a rupture of the fibres, causing bruising. Currently, there is no single protocol-based model of treatment. We present the case of a patient diagnosed with complete muscular rupture of the plantaris muscle by an indirect traumatic mechanism (abrupt muscular elongation), with an associated large-volume hematoma. Clinical study consisted of ultrasound, magnetic resonance (MR), pain assessment (VAS) at the beginning and at the end of the treatment (3 weeks), as well as duration of occupational disability. The patient underwent extracorporeal shockwave therapy (ESWT) according to the protocol. At the end of treatment, the hematoma was resolved and there were no complications. ESWT could be a complementary therapeutic alternative to conventional treatment in this entity. However, there is a need for further, randomised controlled studies including a larger number of patients


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Tratamento por Ondas de Choque Extracorpóreas/métodos , Músculo Esquelético/lesões , Hematoma/diagnóstico por imagem , Ruptura/terapia , Manejo da Dor/métodos , Traumatismos do Pé/terapia , Terapia por Exercício/métodos
6.
Int J Sports Med ; 40(12): 762-767, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31466082

RESUMO

This study compared internal load variable dynamics across three consecutive football matches and investigated its relationship with the number of sprints performed by players. Twenty-three male players had blood and salivary samples collected for hormonal concentration (testosterone, cortisol, and testosterone-cortisol ratio), and serum analysis (interleukin-6, interleukin-1-beta, and c-reactive-protein), respectively. Sprints were measured through Global Position System devices. Testosterone and testosterone-cortisol-ratio presented a decreasing behavior up to the second match, and all other indicators presented an increasing behavior during the same period, c-reactive-protein was the only indicator observed to significantly rise up to the third match as well (0.38±0.02 mg/L; 0.49±0.05 mg/L; 0.69±0.05 mg/L; 0.89±0.08 mg/L). C-reactive-protein showed strong correlations with sprints in the second and third matches (p<0.01, r=0.71 and 0.79), and weak-to-moderate in the first one (p<0.05, r=0.59). Interleukin-6 and interleukin-1-beta presented weak-to-moderate correlation in every match (p<0.05, r=0.48 to 0.51; r=0.51 to 0.55) while testosterone-cortisol ratio presented weak-to-moderate correlation only in the third one (p<0.05, r=0.42). Multilevel linear regression showed that c-reactive-protein had a higher R2 than other biomarker in any regression model (R2=0.624; p<0.001). Therefore, c-reactive-protein can be a valid and reliable indicator of sprinting in competitive football. Future research should explore longer periods of monitoring and/or others external load variables so that other behaviors may arise to knowledge.


Assuntos
Proteína C-Reativa/metabolismo , Comportamento Competitivo/fisiologia , Corrida/fisiologia , Futebol/fisiologia , Adolescente , Biomarcadores/sangue , Biomarcadores/metabolismo , Humanos , Hidrocortisona/sangue , Hidrocortisona/metabolismo , Interleucina-1beta/sangue , Masculino , Músculo Esquelético/lesões , Músculo Esquelético/fisiopatologia , Receptores de Interleucina-6/sangue , Saliva/metabolismo , Testosterona/sangue , Testosterona/metabolismo , Adulto Jovem
7.
Int J Sports Med ; 40(11): 696-703, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31445504

RESUMO

There is a well-conceived notion that rate of recovery from strenuous exercise gets slower with age. However, it is unclear whether older adults who exercise habitually demonstrate slower rates of recovery. We determined whether older adults who are physically active demonstrate slower rates of recovery from unaccustomed strenuous exercise compared with younger peers. Healthy young sedentary (n=10, 28±2 years), young endurance-trained (n=15, 27±2 years), and older endurance-trained (n=14, 58±2 years) men and women were studied. Participants performed 45 min of downhill running at 65% of their maximal oxygen consumption. Visual analog pain scores of muscle groups increased at 24, 48, and 72 h in all three groups (p<0.05), and changes in the muscular pain scale of the legs was smaller in the older trained group than in the young trained group. Maximum isometric strengths at 90° decreased in all groups at 24 h, but the recovery rates were not different at 72 h among the groups. Plasma creatine kinase activity and myoglobin concentration increased at 24 h following downhill running and returned to baseline at 48 h in both the young and older trained groups. The present findings are not consistent with the prevailing notion that older trained adults have a slower rate of recovery from strenuous exercise.


Assuntos
Envelhecimento/fisiologia , Mialgia/fisiopatologia , Resistência Física/fisiologia , Aptidão Física/fisiologia , Corrida/fisiologia , Adulto , Creatina Quinase/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Força Muscular/fisiologia , Músculo Esquelético/lesões , Músculo Esquelético/fisiopatologia , Mialgia/etiologia , Mioglobina/sangue , Consumo de Oxigênio/fisiologia , Amplitude de Movimento Articular , Corrida/lesões
8.
Khirurgiia (Mosk) ; (7): 96-104, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31355822

RESUMO

Injury of gluteus medius muscle is a serious often complication after hip replacement surgery followed by pain, claudication and significant deterioration of the quality of life. Prevention of intraoperative injury of this muscle is especially relevant in young patients. Normal function of this muscle provides rapid rehabilitation and early postoperative recovery. However, hip replacement surgery through Hardinge's direct lateral approach is accompanied by fatty degeneration of gluteus medius muscle in 12-20% of cases. Moreover, two or more redo procedures lead to fatty degeneration of almost 70% of anterior and 40% of central muscular segment. Currently, there are many methods of surgical treatment of this complication including transosseous muscle fixation, endoscopic procedures, repair using Achilles tendon, gluteus maximus muscle, lateral head of quadriceps muscle and allografts. However, various publications devoted to this problem have certain disadvantages including short follow-up period, small sample size and often unsatisfactory outcomes. Therefore, the question of surgical repair of hip abductor function remains open.


Assuntos
Artroplastia de Quadril/efeitos adversos , Músculo Esquelético/lesões , Músculo Esquelético/cirurgia , Lesões dos Tecidos Moles/cirurgia , Artroplastia de Quadril/métodos , Nádegas , Humanos , Lesões dos Tecidos Moles/etiologia
9.
Sensors (Basel) ; 19(15)2019 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-31357650

RESUMO

Wearable robotic braces have the potential to improve rehabilitative therapies for patients suffering from musculoskeletal (MSK) conditions. Ideally, a quantitative assessment of health would be incorporated into rehabilitative devices to monitor patient recovery. The purpose of this work is to develop a model to distinguish between the healthy and injured arms of elbow trauma patients based on electromyography (EMG) data. Surface EMG recordings were collected from the healthy and injured limbs of 30 elbow trauma patients while performing 10 upper-limb motions. Forty-two features and five feature sets were extracted from the data. Feature selection was performed to improve the class separation and to reduce the computational complexity of the feature sets. The following classifiers were tested: linear discriminant analysis (LDA), support vector machine (SVM), and random forest (RF). The classifiers were used to distinguish between two levels of health: healthy and injured (50% baseline accuracy rate). Maximum fractal length (MFL), myopulse percentage rate (MYOP), power spectrum ratio (PSR) and spike shape analysis features were identified as the best features for classifying elbow muscle health. A majority vote of the LDA classification models provided a cross-validation accuracy of 82.1%. The work described in this paper indicates that it is possible to discern between healthy and injured limbs of patients with MSK elbow injuries. Further assessment and optimization could improve the consistency and accuracy of the classification models. This work is the first of its kind to identify EMG metrics for muscle health assessment by wearable rehabilitative devices.


Assuntos
Cotovelo/diagnóstico por imagem , Eletromiografia , Músculo Esquelético/diagnóstico por imagem , Ferimentos e Lesões/diagnóstico por imagem , Adulto , Algoritmos , Análise Discriminante , Cotovelo/lesões , Cotovelo/fisiopatologia , Feminino , Humanos , Masculino , Músculo Esquelético/lesões , Músculo Esquelético/fisiopatologia , Reconhecimento Automatizado de Padrão/métodos , Processamento de Sinais Assistido por Computador , Máquina de Vetores de Suporte , Dispositivos Eletrônicos Vestíveis , Ferimentos e Lesões/fisiopatologia , Ferimentos e Lesões/reabilitação
10.
J Sports Sci Med ; 18(2): 223-228, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31191091

RESUMO

Muscle structure disorganization is a consequence of intense eccentric contractions, with symptoms that characterize exercise-induced muscle damage (EIMD). To date, few studies have described EIMD parameters at different muscle sites. The aim of the present study was to analyse indirect markers of EIMD at two elbow flexors sites over three days. Eleven healthy untrained men were submitted to a session of three sets of 10 eccentric elbow flexion repetitions on an isokinetic dynamometer. The isometric peak torque (PT), muscle soreness, elbow flexors oedema, (normalized muscle thickness [MT]) and echo-intensity (EI) were measured. There was a significant decrease in PT immediately after (Post) and 10 min, 24 h, 48 h and 72 h after intervention compared to that at baseline (p < 0 .05). MT% increased after 72 h compared with that immediately, 10 min and 24 h after intervention (p < 0.05). No statistical changes were observed in muscle soreness and oedema between the two muscle sites. With respect to EI%, significant differences were observed for the 24 h, 48 h and 72 h measures compared with those of the Post, 10 min and 24 h measures for both muscle sites; at the distal site, EI% was significantly higher than at the proximal site for measures after 24 h (p < 0.05). The presence of differences in EI% 24 h after eccentric training on distal sites of elbow flexors indicates non-uniform EIMD in this region.


Assuntos
Cotovelo/fisiologia , Contração Isométrica , Músculo Esquelético/lesões , Mialgia , Treinamento de Resistência/efeitos adversos , Adulto , Edema , Humanos , Masculino , Dinamômetro de Força Muscular , Músculo Esquelético/diagnóstico por imagem , Medição da Dor , Torque , Ultrassonografia , Adulto Jovem
11.
Med Probl Perform Art ; 34(2): 102-104, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31152653

RESUMO

The anconeus muscle is a small and minor functioning muscle located at the posterolateral elbow region. It helps forearm extension and tightening of the joint capsule. Despite its limited functions, pathologies of the anconeus muscle can mimic other abnormalities of the elbow joint. Here, we report a rare case of a traumatic anconeus muscle contusion in a 15-year-old boy due to falling during dance. MRI showed contusion in the anconeus muscle, as well as strain in the ulnar collateral ligament and edema in the coronoid process of the ulna. To our knowledge, this is the first described case of traumatic anconeus muscle contusion in the literature. The presence of long-lasting lateral elbow pain in trauma cases without fracture should alert clinicians to consider anconeus muscle abnormalities. MRI is the best modality for diagnosis in these cases.


Assuntos
Contusões , Articulação do Cotovelo , Músculo Esquelético , Acidentes por Quedas , Adolescente , Dança , Cotovelo , Humanos , Masculino , Músculo Esquelético/lesões , Dor
12.
Bone Joint J ; 101-B(6_Supple_B): 116-122, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31146555

RESUMO

AIMS: The aims of this study were to assess the exposure and preservation of the abductor mechanism during primary total hip arthroplasty (THA) using the posterior approach, and to evaluate gluteus maximus transfer to restore abductor function of chronically avulsed gluteus medius and minimus. PATIENTS AND METHODS: A total of 519 patients (525 hips) underwent primary THA using the posterior approach, between 2009 and 2013. The patients were reviewed preoperatively and at two and five years postoperatively. Three patients had mild acute laceration of the gluteus medius caused by retraction. A total of 54 patients had mild chronic damage to the tendon (not caused by exposure), which was repaired with sutures through drill holes in the greater trochanter. A total of 41 patients had severe damage with major avulsion of the gluteus medius and minimus muscles, which was repaired with sutures through bone and a gluteus maximus flap transfer to the greater trochanter. RESULTS: Abductor strength was maintained in the normal hips, but lateral hip pain progressed significantly, five years postoperatively (p < 0.0001). In the 54 patients with mild abductor tendon damage treated with simple repair, lateral hip pain also increased significantly during follow-up (p = 0.002). In the 35 patients with severe avulsion but good muscle repaired using a gluteus maximus flap transfer, abductor function was restored. The six patients with complete avulsion and poor muscle did not regain strong abductor power, but lateral hip pain decreased. CONCLUSION: The posterior approach offered excellent exposure and preservation of the abductor mechanism during primary THA. Augmentation of the repair with a gluteus maximus flap provided stable reconstruction of the abductor muscles and seemed to restore function in the hips with functioning muscles. Cite this article: Bone Joint J 2019;101-B(6 Supple B):116-122.


Assuntos
Artroplastia de Quadril/efeitos adversos , Tendinopatia/etiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Artroplastia de Quadril/métodos , Feminino , Humanos , Complicações Intraoperatórias/etiologia , Complicações Intraoperatórias/fisiopatologia , Masculino , Pessoa de Meia-Idade , Força Muscular/fisiologia , Músculo Esquelético/lesões , Músculo Esquelético/fisiopatologia , Complicações Pós-Operatórias/etiologia , Técnicas de Sutura , Tendinopatia/fisiopatologia , Traumatismos dos Tendões/etiologia , Traumatismos dos Tendões/fisiopatologia
13.
Mol Med Rep ; 20(1): 709-718, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31180563

RESUMO

Anti­apoptotic and anti­inflammatory treatments are imperative for skeletal muscle regeneration following injury. Baicalin is well known and has previously been investigated for its role in the treatment of injury and inflammatory diseases. Therefore, the present study aimed to investigate the effects of baicalin in inhibiting apoptosis of C2C12 myoblasts and preventing skeletal muscle injury. A cell counting kit­8 (CCK­8) assay and Annexin V/PI staining were initially performed to measure cell viability and apoptosis under conditions of H2O2 exposure with or without baicalin. Subsequently, oxidative activity, mitochondrial function, mitochondrial apoptogenic factors and caspase proteins were analyzed to examine the mechanism underlying the effect of baicalin on inhibiting apoptosis in C2C12 myoblasts. Furthermore, BALB/C mice with skeletal muscle injuries were established, and the potential application of baicalin for anti­apoptotic and anti­inflammatory effects was examined via small animal ß­2­[18F]­fluoro­2­deoxy­D­glucose (18F­FDG) positron emission tomography (PET) imaging and pathological examination. The CCK­8 assay and Annexin V/PI staining revealed cell death in the C2C12 myoblasts induced by H2O2, which was apoptotic, and this was effectively reversed by treatment with baicalin. H2O2 increased the reactive oxygen species and malondialdehyde levels in C2C12 myoblasts, which was caused by mitochondrial dysfunction, decreased expression of cytochrome c and apoptosis­inducing factor from cytosolic and mitochondrial fractions, and activated expression of caspase­3 and caspase­9; however, treatment with baicalin reversed these effects. In addition, small animal PET imaging revealed that treatment with baicalin decreased the accumulation of FDG by ~65.9% in the injured skeletal muscle induced by H2O2. These pathological results also confirmed the protective effect of baicalin on injured skeletal muscle. Taken together, the results of the present study indicated that baicalin effectively inhibited the apoptosis of C2C12 myoblasts and protected skeletal muscle from injury, which may have potential therapeutic benefits for patients in a clinical setting.


Assuntos
Anti-Inflamatórios não Esteroides/uso terapêutico , Apoptose/efeitos dos fármacos , Flavonoides/uso terapêutico , Músculo Esquelético/efeitos dos fármacos , Músculo Esquelético/lesões , Mioblastos/efeitos dos fármacos , Animais , Anti-Inflamatórios não Esteroides/química , Anti-Inflamatórios não Esteroides/farmacologia , Linhagem Celular , Feminino , Flavonoides/química , Flavonoides/farmacologia , Camundongos Endogâmicos BALB C , Mitocôndrias/efeitos dos fármacos , Mitocôndrias/metabolismo , Mitocôndrias/patologia , Músculo Esquelético/metabolismo , Músculo Esquelético/patologia , Mioblastos/metabolismo , Mioblastos/patologia , Estresse Oxidativo/efeitos dos fármacos , Espécies Reativas de Oxigênio/metabolismo , Scutellaria baicalensis/química
14.
Niger J Clin Pract ; 22(6): 777-781, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31187761

RESUMO

Background: Sharp and penetrating object injuries (SPOIs) are seen frequently in forensic medicine practice. In this study, we aimed to retrospectively investigate cases with SPOIs. Materials and Methods: This study investigated the charts of patients treated at Adiyaman University Education and Research Hospital between January 1, 2013, and December 31, 2017. A total of 934 inpatients with sharp object injuries were included in the study. Data were assessed using a suitable computer-aided package program. Cases were examined in terms of age, gender, injury body site, suicide or homicide, radiologic findings, presence of vital danger, and severity of injury. Results: In this study, we examined the charts for 934 inpatients with stab wounds. It was stated that 124 (13.27%) of those injured were female and 810 (86.63%) male; the average age of the injured persons was 29.8 ± 18.2 years. It was found that 214 (22.91%) people were exposed to vital danger and that 720 (77.09%) suffered from soft tissue injuries (penetrating skin and muscle injuries). Also, 69.27% of the cases (n = 647) involved people less than 35 years of age. Conclusion: Considering that stab injuries are more frequent in the lower age groups, we believe that such injuries could be reduced by increasing training programs for young people.


Assuntos
Lesões dos Tecidos Moles/etiologia , Tentativa de Suicídio , Violência , Ferimentos Perfurantes/etiologia , Adolescente , Adulto , Fatores Etários , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Músculo Esquelético/lesões , Estudos Retrospectivos , Pele/lesões , Turquia/epidemiologia , Adulto Jovem
15.
Cell Physiol Biochem ; 53(1): 62-75, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31184447

RESUMO

BACKGROUND/AIMS: Skeletal muscle injuries are the most common type of injury occurring in sports, and investigating skeletal muscle regeneration as well as understanding the related processes is an important aspect of the sports medicine field. The process of regeneration appears to be complex and precisely orchestrated, involving fibro-adipogenic progenitors (FAPs) which are a muscle-resident stem cell population that appears to play a major role in abnormal development of fibrotic tissue or intermuscular adipose tissue (IMAT). Our present study aims to investigate whether muscle resting or endurance exercise following muscle injury may change the behavior of FAPs and subsequently impact the development of fatty infiltrations and fibrosis, two hallmarks of regeneration failure. METHODS: We used the validated glycerol muscle injury model to mimic abnormal muscle regenerative conditions in mice. We challenged this specific regeneration model with hindlimb unloading or endurance exercise and, in a second set of experiments, we treated mice with decorin, a TGF-ß inhibitor. RESULTS: In this study, we demonstrated that: i) muscle resting just after injury leads to inhibition of IMAT development, ii) TNF-α mediated FAP apoptosis might be perturbed in this specific glycerol model of muscle injury, leading to IMAT development, and iii) treatment with the TGF-ß inhibitor decorin decreases IMAT development and might restores FAP apoptosis. CONCLUSION: In addition to the potential clinical relevance of decorin treatment in situations involving muscle plasticity and regeneration, this study also demonstrates that a period of muscle resting is necessary following muscle injury to achieve efficient muscle regeneration which is associated with a reduction in fatty infiltration. Unreasonably early resumption of exercise brings no gain to regeneration, further highlighting that this resting period is necessary.


Assuntos
Decorina/uso terapêutico , Músculo Esquelético/lesões , Doenças Musculares/tratamento farmacológico , Fator de Crescimento Transformador beta/antagonistas & inibidores , Tecido Adiposo/efeitos dos fármacos , Tecido Adiposo/metabolismo , Animais , Apoptose/efeitos dos fármacos , Decorina/farmacologia , Feminino , Glicerol/toxicidade , Camundongos , Camundongos Endogâmicos C57BL , Músculo Esquelético/patologia , Doenças Musculares/induzido quimicamente , Doenças Musculares/patologia , Condicionamento Físico Animal , Receptor alfa de Fator de Crescimento Derivado de Plaquetas/metabolismo , Células-Tronco/citologia , Células-Tronco/efeitos dos fármacos , Células-Tronco/metabolismo , Fator de Crescimento Transformador beta/metabolismo
16.
Phys Ther Sport ; 39: 8-15, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31202143

RESUMO

OBJECTIVES: The purpose of the current study was to compare injury and running history among current and former runners who consider themselves either injured or uninjured. DESIGN: Cross-sectional survey. SETTING: Online survey, available to any individuals over the age of 18 who currently run (runners) or who once ran regularly but are no longer running (former runners). PARTICIPANTS: 312 participants (age 38 ±â€¯12 years, 219 males, 89 females, 4 did not disclose) completed the survey. MAIN OUTCOME MEASURES: This study assessed injury incidence, consequences of injury such as time off, and reported injury diagnoses and treatments. Chi-square and frequency analyses were calculated to describe running status, injury counts, and response to injury. RESULTS: Most participants (80%) reported 1 + running injury. 775 total injuries were reported. The four most common injuries were iliotibial band syndrome (34%), plantar fasciitis (30%), strained thigh/hip muscle (25%), and medial tibial stress syndrome (22%). About 40% of participants continued to run with these injuries. CONCLUSIONS: Injury frequencies (80%) agreed with those reported in the literature. The results of this study also support the notion that running injuries exist on a continuum of severity and that the individual response to injury is complex and determined by various factors.


Assuntos
Corrida/lesões , Adolescente , Adulto , Idoso , Estudos Transversais , Feminino , Humanos , Síndrome da Banda Iliotibial/etiologia , Incidência , Masculino , Síndrome da Tensão Tibial Medial/etiologia , Pessoa de Meia-Idade , Músculo Esquelético/lesões , Autorrelato , Entorses e Distensões/etiologia , Inquéritos e Questionários , Adulto Jovem
17.
J Sci Med Sport ; 22(9): 992-996, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31239202

RESUMO

OBJECTIVES: To investigate the reliability of reporting and relationship between MRI parameters at injury and time to return to play (RTP) in first class cricket fast bowlers with side strain in Australia and England. DESIGN: Cohort study. METHODS: Eighty MRI scans of side strain injuries to 57 fast bowlers were sourced. Ten scans were reported by three experienced radiologists to determine intra- and inter-rater reliability. The relationship between six MRI parameters (muscle injured, presence of a muscle tear, rib level of injury, presence of blood fluid products/haematoma, periosteal stripping, rib oedema) and time to RTP was investigated with 39 scans reported by a single radiologist with known intra-rater reliability. The association between parameters and time to RTP was analysed with an ordinal logistic regression model. RESULTS: Recovery time was prolonged with a mean of 39days (standard deviation: 14days) and 44% of bowlers requiring more than 6weeks to RTP. Reliability levels between parameters varied widely. The presence or absence of a muscle tear was the only MRI parameter associated with time to RTP. Players with a muscle tear were 8 times more likely to take more than 6weeks to RTP. The multifactorial model was predictive of recovery time in only 53% of this cohort, leaving 47% of total variance in time to RTP unexplained. CONCLUSIONS: The presence of a muscle tear was associated with time to RTP in cricket fast bowlers with side strain injury in first class cricket in Australia and England.


Assuntos
Traumatismos em Atletas/diagnóstico por imagem , Músculo Esquelético/lesões , Volta ao Esporte , Entorses e Distensões/diagnóstico por imagem , Adolescente , Adulto , Austrália , Estudos de Coortes , Inglaterra , Humanos , Imagem por Ressonância Magnética , Músculo Esquelético/diagnóstico por imagem , Variações Dependentes do Observador , Reprodutibilidade dos Testes , Esportes , Adulto Jovem
18.
J Mol Histol ; 50(4): 375-387, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31218594

RESUMO

Dysferlin is a sarcolemmal muscle protein associated with the processes of membrane repair, trafficking, and fusion of intracellular vesicles and muscle regeneration. Mutations in the DYSF gene cause clinically distinct forms of muscular dystrophies. The dysferlin-deficient SJL/J mouse model presents a reduction of 85% of the protein but shows mild weakness and discrete histopathological alterations. To study the effect of dysferlin deficiency in the muscle regenerative process, we used a model of electrical injury by electroporation to induce muscle degeneration/regeneration in the SJL/J mouse. The relative expression of the genes Pax7, MyoD, Myf5, and Myog was accompanied by the histopathological evaluation during muscle recovery at different time points after injury. We also investigated the effects of dysferlin deficiency in the expression of genes encoding FAM65B and HDAC6 proteins, recently described as forming a tricomplex with dysferlin at the beginning of myoblast differentiation. We observed an altered time course through the process of degeneration and regeneration in dysferlin-deficient mice, with remarkable regenerative capacity characterized by a faster and effective response in the first days after injury, as compared to the WT mice. Also, dysferlin deficiency seems to significantly alter the gene expression of Fam65b and Hdac6 during regeneration, since higher levels of expression of both genes were observed in dysferlin-deficient mice. These results need further attention to define their relevance in the disease mechanism.


Assuntos
Moléculas de Adesão Celular/metabolismo , Disferlina/deficiência , Desacetilase 6 de Histona/metabolismo , Músculo Esquelético/fisiologia , Regeneração/efeitos dos fármacos , Animais , Moléculas de Adesão Celular/farmacologia , Disferlina/farmacologia , Disferlina/fisiologia , Regulação da Expressão Gênica/efeitos dos fármacos , Desacetilase 6 de Histona/farmacologia , Camundongos , Músculo Esquelético/lesões , Fatores de Tempo
19.
Fa Yi Xue Za Zhi ; 35(2): 154-159, 2019 Apr.
Artigo em Inglês, Chinês | MEDLINE | ID: mdl-31135108

RESUMO

Abstract: Objective To study the expressions of transforming growth factor-ß1 (TGF-ß1) and EⅢA-fibronectin (EⅢA-FN) at different time points of antemortem injury, antemortem injury postmortem expression and postmortem injury and to explore their application value in wound age estimation. Methods A model of rat skeletal muscle contusion was established. The rats were randomly divided into normal control group (n=5), antemortem contusion group (n=40), antemortem contusion postmortem expression group (n=110) and postmortem injury group (n=25). The expressions of TGF-ß1 and EⅢA-FN after rat skeletal muscles antemortem contusion were detected with immunohistochemical staining. Expression changes of TGF-ß1 and EⅢA-FN mRNA in each group were analyzed with real-time fluorescence quantitative PCR. Results Immunohistochemical staining results showed that a large number of polymorphonuclear leukocyte, mononuclear cells and fibroblastic cells showed a strong expression of TGF-ß1 in wounded zones 12 h-14 d after antemortem contusion. EⅢA-FN was mainly distributed in the extracellular matrix, 3 to 7 d post-traumatic. Real-time fluorescence quantitative PCR results showed that TGF-ß1 and EⅢA-FN mRNA in antemortem injury group reached the peak at 3 and 5 d post-traumatic respectively. The expressions of TGF-ß1 and EⅢA-FN mRNA in antemortem contusion postmortem expression group peaked at 6 h and 12 h postmortem. The expression of TGF-ß1 and EⅢA-FN mRNA in postmortem injury group 0.5-12 h postmortem was significantly lower than those of the normal control group and the antemortem contusion group. Conclusion TGF-ß1 and EⅢA-FN might become a reference index for skeletal muscle wound age estimation.


Assuntos
Contusões/metabolismo , Fibronectinas/genética , Músculo Esquelético/metabolismo , Fator de Crescimento Transformador beta1/genética , Animais , Biomarcadores/metabolismo , Fibroblastos , Fibronectinas/metabolismo , Músculo Esquelético/lesões , Mudanças Depois da Morte , Distribuição Aleatória , Ratos , Fator de Crescimento Transformador beta1/metabolismo
20.
Fa Yi Xue Za Zhi ; 35(2): 160-165, 2019 Apr.
Artigo em Inglês, Chinês | MEDLINE | ID: mdl-31135109

RESUMO

Abstract: Objective To investigate the estimation of early and mid-term wound age by a combination of four mRNAs, the DNA polymerase delta-interacting protein 3 (POLDIP3) mRNA, regulator of chromosome condensation 1 like (RCC1L) mRNA, proline-rich 5 (PRR5) mRNA, and ribonucleic acid export 1 (RAE1) mRNA in rats skeletal muscles. Methods The model of rat skeletal muscle contusion was established, and then contusion area muscle tissue was extracted 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44 and 48 h after injury. Histomorphological changes during the repair process after rat skeletal muscle contusion were observed. The relative expressions of Poldip3, Rcc1l, Prr5 and Rae1 mRNAs were detected by reverse transcription real-time quantitative polymerase chain reaction (RT-qPCR). Different stages of wound age were classified by using the expression patterns of four genes at various time points after injury. The accuracy of the results was verified by Fisher discriminant analysis. Results Histomorphological results showed that the repair process after skeletal muscle contusion occurred with the prolonging of time. Through combination of the expression trends of the four kinds of mRNAs, the 48 h after injury could be divided into three periods, 4-12 h, 16-28 h and 32-48 h. The Fisher discrimination method showed that the classification accuracy rates of the three periods were 83.3%, 75.0% and 73.3%, respectively. Conclusion The classification discrimination based on the relative expression of every gene has a higher accuracy, and the accuracy of wound age estimation with combination of mRNA relative expressions is higher than that with a single indicator. By combining with Fisher discrimination method, this method can be used for early and mid-term wound age estimation.


Assuntos
Contusões/metabolismo , Músculo Esquelético/lesões , Músculo Esquelético/metabolismo , RNA Mensageiro/genética , Animais , Ratos , Ratos Sprague-Dawley , Fatores de Tempo
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