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Nurs Open ; 8(3): 1005-1022, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-34482649


AIM: To provide a systematic review of the literature from 1997 to 2017 on nursing-sensitive indicators. DESIGN: A qualitative design with a deductive approach was used. DATA SOURCES: Original and Grey Literature references from Cochrane Library, Medline/PubMed, Embase, and CINAHL, Google Scholar Original and Grey Literature. REVIEW METHODS: Quality assessment was performed using the NIH Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. RESULTS: A total of 3,633 articles were identified, and thirty-nine studies met the inclusion criteria. The quantitative assessment of investigated relationships in these studies suggests that nursing staffing, mortality, and nosocomial infections were the most frequently reported nursing-sensitive indicators. CONCLUSION: This review provides a comprehensive list of nursing-sensitive indicators, their frequency of use, and the associations between these indicators and various outcome variables. Stakeholders of nursing research may use the findings to streamline the indicator development efforts and standardization of nursing-sensitive indicators. IMPACT: This review provides evidence-based results that health organizations can benefit from nursing care quality.

Cuidados de Enfermagem , Pesquisa em Enfermagem , Recursos Humanos de Enfermagem , Estudos Transversais , Humanos , MEDLINE
F1000Res ; 10: 401, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34408850


Background: The reliable and usable (semi)automation of data extraction can support the field of systematic review by reducing the workload required to gather information about the conduct and results of the included studies. This living systematic review examines published approaches for data extraction from reports of clinical studies. Methods: We systematically and continually search MEDLINE, Institute of Electrical and Electronics Engineers (IEEE), arXiv, and the dblp computer science bibliography databases. Full text screening and data extraction are conducted within an open-source living systematic review application created for the purpose of this review. This iteration of the living review includes publications up to a cut-off date of 22 April 2020. Results: In total, 53 publications are included in this version of our review. Of these, 41 (77%) of the publications addressed extraction of data from abstracts, while 14 (26%) used full texts. A total of 48 (90%) publications developed and evaluated classifiers that used randomised controlled trials as the main target texts. Over 30 entities were extracted, with PICOs (population, intervention, comparator, outcome) being the most frequently extracted. A description of their datasets was provided by 49 publications (94%), but only seven (13%) made the data publicly available. Code was made available by 10 (19%) publications, and five (9%) implemented publicly available tools. Conclusions: This living systematic review presents an overview of (semi)automated data-extraction literature of interest to different types of systematic review. We identified a broad evidence base of publications describing data extraction for interventional reviews and a small number of publications extracting epidemiological or diagnostic accuracy data. The lack of publicly available gold-standard data for evaluation, and lack of application thereof, makes it difficult to draw conclusions on which is the best-performing system for each data extraction target. With this living review we aim to review the literature continually.

Publicações , Relatório de Pesquisa , Automação , Bases de Dados Bibliográficas , MEDLINE
BMC Med Res Methodol ; 21(1): 152, 2021 07 26.
Artigo em Inglês | MEDLINE | ID: mdl-34311695


BACKGROUND: Cluster randomised trials (CRTs) are increasingly used to evaluate non-pharmacological interventions for improving child health. Although methodological challenges of CRTs are well documented, the characteristics of school-based CRTs with pupil health outcomes have not been systematically described. Our objective was to describe methodological characteristics of these studies in the United Kingdom (UK). METHODS: MEDLINE was systematically searched from inception to 30th June 2020. Included studies used the CRT design in schools and measured primary outcomes on pupils. Study characteristics were described using descriptive statistics. RESULTS: Of 3138 articles identified, 64 were included. CRTs with pupil health outcomes have been increasingly used in the UK school setting since the earliest included paper was published in 1993; 37 (58%) studies were published after 2010. Of the 44 studies that reported information, 93% included state-funded schools. Thirty six (56%) were exclusively in primary schools and 24 (38%) exclusively in secondary schools. Schools were randomised in 56 studies, classrooms in 6 studies, and year groups in 2 studies. Eighty percent of studies used restricted randomisation to balance cluster-level characteristics between trial arms, but few provided justification for their choice of balancing factors. Interventions covered 11 different health areas; 53 (83%) included components that were necessarily administered to entire clusters. The median (interquartile range) number of clusters and pupils recruited was 31.5 (21 to 50) and 1308 (604 to 3201), respectively. In half the studies, at least one cluster dropped out. Only 26 (41%) studies reported the intra-cluster correlation coefficient (ICC) of the primary outcome from the analysis; this was often markedly different to the assumed ICC in the sample size calculation. The median (range) ICC for school clusters was 0.028 (0.0005 to 0.21). CONCLUSIONS: The increasing pool of school-based CRTs examining pupil health outcomes provides methodological knowledge and highlights design challenges. Data from these studies should be used to identify the best school-level characteristics for balancing the randomisation. Better information on the ICC of pupil health outcomes is required to aid the planning of future CRTs. Improved reporting of the recruitment process will help to identify barriers to obtaining representative samples of schools.

Avaliação de Resultados em Cuidados de Saúde , Instituições Acadêmicas , Criança , Humanos , MEDLINE , Ensaios Clínicos Controlados Aleatórios como Assunto , Reino Unido
BMC Med Inform Decis Mak ; 21(1): 223, 2021 07 22.
Artigo em Inglês | MEDLINE | ID: mdl-34294092


BACKGROUND: Testing a hypothesis for 'factors-outcome effect' is a common quest, but standard statistical regression analysis tools are rendered ineffective by data contaminated with too many noisy variables. Expert Systems (ES) can provide an alternative methodology in analysing data to identify variables with the highest correlation to the outcome. By applying their effective machine learning (ML) abilities, significant research time and costs can be saved. The study aims to systematically review the applications of ES in urological research and their methodological models for effective multi-variate analysis. Their domains, development and validity will be identified. METHODS: The PRISMA methodology was applied to formulate an effective method for data gathering and analysis. This study search included seven most relevant information sources: WEB OF SCIENCE, EMBASE, BIOSIS CITATION INDEX, SCOPUS, PUBMED, Google Scholar and MEDLINE. Eligible articles were included if they applied one of the known ML models for a clear urological research question involving multivariate analysis. Only articles with pertinent research methods in ES models were included. The analysed data included the system model, applications, input/output variables, target user, validation, and outcomes. Both ML models and the variable analysis were comparatively reported for each system. RESULTS: The search identified n = 1087 articles from all databases and n = 712 were eligible for examination against inclusion criteria. A total of 168 systems were finally included and systematically analysed demonstrating a recent increase in uptake of ES in academic urology in particular artificial neural networks with 31 systems. Most of the systems were applied in urological oncology (prostate cancer = 15, bladder cancer = 13) where diagnostic, prognostic and survival predictor markers were investigated. Due to the heterogeneity of models and their statistical tests, a meta-analysis was not feasible. CONCLUSION: ES utility offers an effective ML potential and their applications in research have demonstrated a valid model for multi-variate analysis. The complexity of their development can challenge their uptake in urological clinics whilst the limitation of the statistical tools in this domain has created a gap for further research studies. Integration of computer scientists in academic units has promoted the use of ES in clinical urological research.

Neoplasias da Próstata , Urologia , Sistemas Especialistas , Humanos , MEDLINE , Aprendizado de Máquina , Masculino
Arch Pediatr ; 28(6): 464-469, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34140220


INTRODUCTION: At the end of April 2020, three European pediatric societies published an alert on a new hyperinflammatory disorder linked to SARS-CoV-2. This disease has alternatively been called Kawasaki-like disease, pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS), and multisystem inflammatory syndrome in children (MIS-C). These alerts provide a clear starting point from which to study the early response of the medical and scientific community to a new disease in terms of scientific publications, and to compare the timeline of this response with levels of general public interest. To this aim, we conducted a bibliometric analysis of articles on this disease published between 1 April and 5 July 2020. METHOD: A literature search was performed using PubMed and in three preprint repositories. For each article, the name used for the disease in the title, the number of authors, the number of patients, the citations according to Google Scholar, the journal impact factor, and the Altmetric score were retrieved. Google search trends for the terms "Kawasaki" and "COVID," "COVID-19," and "coronavirus" were also retrieved, as was the number of Reuters news articles published on the topic. These data were compared longitudinally on a weekly basis. The quality of the reporting of the study was evaluated using the STROBE guidelines for observational studies with more than three patients and using the CARE guidelines for case reports of three or fewer patients. RESULTS: Eighty-six articles were included, among which ten were preprints (three of which were subsequently published) and 49 were clinical articles (57%). A total of 857 patients were described. The median number of authors per article was five (range, 1-45), the median number of patients was four (1-186), the median number of citations was one (0-170), the median Altmetric score was 12 (0-7242), and the median journal impact factor was 3.7 (1-74.7). For the clinical articles, the median percentage of STROBE or CARE checklist items satisfied was 70% (IQR, 56.75-79.25; range, 40-90). Guideline adherence was significantly higher for observational studies than for case reports (median percentage of checklist items satisfied, 78.5% vs 61.5%; P<0.001); however, guideline adherence did not differ significantly between peer-reviewed and preprint articles (median percentage of checklist items satisfied, 57% vs 72%; P=0.205). The only statistically significant difference between clinical articles and other types of articles was the number of authors (median, 7 vs 2; P=2.53E-9). Fifty-seven of the 86 articles were authored by researchers from just three countries (the USA, 31; France, 14; and the UK, 12). The names most frequently used in the title were Kawasaki-like disease (n=37), followed by MIS-C (n=27), PIM-TS (n=14), and other names involving the term "inflammatory" (n=12). Google searches for related terms peaked between weeks 18 and 21, following the initial alerts and decreased rapidly thereafter. The number of Reuters articles on the subject was correlated with Google search trends (ρ: 0.86, 95% CI [0.59; 0.96]; P=0.00016), but the number of medical articles published was not (ρ: -0.54, 95% CI [-0.87; 0.14]; P=0.11). The first small case series was published less than 2 weeks after the initial alert; however, if all articles had been deposited as preprints when they were submitted to journals, the cumulative number of reported cases would have been 300% higher in week 18 (3 vs 1), 400% higher in week 19 (44 vs 11), 70% higher in week 20 (124 vs 73), and 54% higher in week 21 (129 vs 84). CONCLUSION: In a period of 9 weeks after the initial alerts from European pediatric societies, 85 medical articles were published, involving 856 patients (one case report was published before the alerts), allowing rapid dissemination of research information. However, general public interest followed the news cycle rather than scientific releases. The quality of the reporting, as assessed by adherence to STROBE or CARE guidelines, was adequate with more than two-thirds of checklist items satisfied. Learned societies play an important role in the early dissemination of up-to-date peer-reviewed information. Preprint deposition should be encouraged to accelerate the dissemination of research information.

Bibliometria , COVID-19 , Editoração/tendências , Síndrome de Resposta Inflamatória Sistêmica , Criança , Humanos , MEDLINE , Pandemias
Stud Health Technol Inform ; 280: 109-112, 2021 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-34190070


Despite application of ultrasound for quantitative measurement of spinal curvatures has been reported with various studies, a systematic review for such is lacking. This systematic review aimed to evaluate (1) reliability of ultrasound; (2) validity of ultrasound using radiographic measurement as gold standard in idiopathic scoliosis patients; and (3) the use of various anatomical landmarks for measurement of spinal curvatures. MEDLINE, EMBASE, CINAHL, and CENTRAL databases were searched. QUADAS-2 quality assessment tool was adopted. Reliability of ultrasound in terms of intra-class correlation coefficient was recorded. Pearson correlation coefficients between ultrasound and radiographic measurements were extracted for meta-analysis. Subgroup analyses based on ultrasound measurement protocols of spinous process (SP), transverse processes (TP) and center of lamina (COL) were conducted. Eleven articles reporting 18 correlation analyses on 766 subjects were eligible for meta-analysis. The mean inter-rater reliability of ultrasound measurement was 0.87±0.07. Pooled correlation for all studies was 0.918 (95% CI: 0.868-0.949), exhibiting substantial heterogeneity (I2=90.50%, p<0.001). Subgroup analyses showed that pooled correlations were 0.887 for COL method (comprising 356 subjects); 0.924 for SP method (255 subjects); and 0.941 for TP method (117 subjects); all with notable heterogeneity (I2>90%, p<0.001). The overall risk of bias was rated moderate; yet publication bias was noted. Evidences showed that ultrasound was a promising non-invasive method with satisfactory validity and reliability for measuring coronal curvatures utilizing the SP, TP or COL methods. Further development of three-dimensional ultrasound towards scoliosis assessment will facilitate its translational application for managing scoliosis.

Escoliose , Curvaturas da Coluna Vertebral , Humanos , MEDLINE , Reprodutibilidade dos Testes , Escoliose/diagnóstico por imagem , Ultrassonografia
PLoS One ; 16(5): e0234221, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33956834


This study compared the results of data collected from a longitudinal query analysis of the MEDLINE database hosted on multiple platforms that include PubMed, EBSCOHost, Ovid, ProQuest, and Web of Science. The goal was to identify variations among the search results on the platforms after controlling for search query syntax. We devised twenty-nine cases of search queries comprised of five semantically equivalent queries per case to search against the five MEDLINE database platforms. We ran our queries monthly for a year and collected search result count data to observe changes. We found that search results varied considerably depending on MEDLINE platform. Reasons for variations were due to trends in scholarly publication such as publishing individual papers online first versus complete issues. Some other reasons were metadata differences in bibliographic records; differences in the levels of specificity of search fields provided by the platforms and large fluctuations in monthly search results based on the same query. Database integrity and currency issues were observed as each platform updated its MEDLINE data throughout the year. Specific biomedical bibliographic databases are used to inform clinical decision-making, create systematic reviews, and construct knowledge bases for clinical decision support systems. They serve as essential information retrieval and discovery tools to help identify and collect research data and are used in a broad range of fields and as the basis of multiple research designs. This study should help clinicians, researchers, librarians, informationists, and others understand how these platforms differ and inform future work in their standardization.

Armazenamento e Recuperação da Informação , MEDLINE , Pesquisa Biomédica , Humanos , Armazenamento e Recuperação da Informação/métodos , Ferramenta de Busca/métodos
BMC Med Res Methodol ; 21(1): 94, 2021 04 30.
Artigo em Inglês | MEDLINE | ID: mdl-33941105


BACKGROUND: Systematic reviews (SRs) are considered one of the most reliable types of studies in evidence-based medicine. SRs rely on a comprehensive and systematic data gathering, including the search of academic literature databases. This study aimed to investigate which combination of databases would result in the highest overall recall rate of references when conducting SRs of qualitative research regarding diabetes mellitus. Furthermore, we aimed to investigate the current use of databases and other sources for data collection. METHODS: Twenty-six SRs (published between 2010 and 2020) of qualitative research regarding diabetes mellitus, located through PubMed, met the inclusion criteria. References of the SRs were systematically hand searched in the six academic literature databases CINAHL, MEDLINE/PubMed, PsycINFO, Embase, Web of Science, and Scopus and the academic search engine Google Scholar. Recall rates were calculated using the total number of included references retrieved by the database or database combination divided by the total number of included references, given in percentage. RESULTS: The SRs searched five databases on average (range two to nine). MEDLINE/PubMed was the most commonly searched database (100% of SRs). In addition to academic databases, 18 of the 26 (69%) SRs hand searched the reference lists of included articles. This technique resulted in a median (IQR) of 2.5 (one to six) more references being included per SR than by database searches alone. 27 (5.4%) references were found only in one of six databases (when Google Scholar was excluded), with CINAHL retrieving the highest number of unique references (n = 15). The combinations of MEDLINE/PubMed and CINAHL (96.4%) and MEDLINE/PubMed, CINAHL, and Embase (98.8%) yielded the highest overall recall rates, with Google Scholar excluded. CONCLUSIONS: We found that the combinations of MEDLINE/PubMed and CINAHL and MEDLINE/PubMed, CINAHL, and Embase yielded the highest overall recall rates of references included in SRs of qualitative research regarding diabetes mellitus. However, other combinations of databases yielded corresponding recall rates and are expected to perform comparably. Google Scholar can be a useful supplement to traditional scientific databases to ensure an optimal and comprehensive retrieval of relevant references.

Diabetes Mellitus , Armazenamento e Recuperação da Informação , Diabetes Mellitus/terapia , Humanos , MEDLINE , Pesquisa Qualitativa , Revisões Sistemáticas como Assunto
Stud Health Technol Inform ; 281: 342-346, 2021 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-34042762


For many decades English language was dominant in international scientific communications, but during the last decade it threatens to become the only language for communicating medical science at international level. The aim of this article was to make an overview of publication practices in regard to language of publication of MEDLINE-referenced articles from European countries in year 2020. Scientific publications referenced in MEDLINE database during year 2020 were chosen for analysis. The inclusion criteria were publications affiliated with one of European countries, published in either English or national languages of those countries. The countries with less than 100.000 inhabitants were excluded from the study. Only 11 of 38 European countries had any number of medical publications in national language that were referenced in MEDLINE; the authors from twenty-seven European countries completely stopped publishing in national language at international journals. While economic strenght of a country was strongly correlated with number of international publications per 100.000 inhabitants, the correlation with international papers published in national languages was much less pronounced. Researchers from majority of European countries are publishing their studies predominantly or only in international medical journals printed in English language. Additional efforts should be made in the future to promote publishing in national languages.

Bibliometria , Idioma , Europa (Continente) , Humanos , MEDLINE , Pesquisadores
Artif Intell Med ; 114: 102053, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33875160


MOTIVATION: In the age of big data, the amount of scientific information available online dwarfs the ability of current tools to support researchers in locating and securing access to the necessary materials. Well-structured open data and the smart systems that make the appropriate use of it are invaluable and can help health researchers and professionals to find the appropriate information by, e.g., configuring the monitoring of information or refining a specific query on a disease. METHODS: We present an automated text classifier approach based on the MEDLINE/MeSH thesaurus, trained on the manual annotation of more than 26 million expert-annotated scientific abstracts. The classifier was developed tailor-fit to the public health and health research domain experts, in the light of their specific challenges and needs. We have applied the proposed methodology on three specific health domains: the Coronavirus, Mental Health and Diabetes, considering the pertinence of the first, and the known relations with the other two health topics. RESULTS: A classifier is trained on the MEDLINE dataset that can automatically annotate text, such as scientific articles, news articles or medical reports with relevant concepts from the MeSH thesaurus. CONCLUSIONS: The proposed text classifier shows promising results in the evaluation of health-related news. The application of the developed classifier enables the exploration of news and extraction of health-related insights, based on the MeSH thesaurus, through a similar workflow as in the usage of PubMed, with which most health researchers are familiar.

Comunicação em Saúde/normas , MEDLINE/organização & administração , Medical Subject Headings , Pesquisa/organização & administração , Big Data , COVID-19/epidemiologia , Classificação , Diabetes Mellitus/epidemiologia , Humanos , MEDLINE/normas , Saúde Mental/estatística & dados numéricos , SARS-CoV-2 , Semântica
BMC Med Res Methodol ; 21(1): 81, 2021 04 22.
Artigo em Inglês | MEDLINE | ID: mdl-33888077


BACKGROUND: Identifying how unwarranted variations in healthcare delivery arise is challenging. Experimental vignette studies can help, by isolating and manipulating potential drivers of differences in care. There is a lack of methodological and practical guidance on how to design and conduct these studies robustly. The aim of this study was to locate, methodologically assess, and synthesise the contribution of experimental vignette studies to the identification of drivers of unwarranted variations in healthcare delivery. METHODS: We used a scoping review approach. We searched MEDLINE, Embase, Web of Science and CINAHL databases (2007-2019) using terms relating to vignettes and variations in healthcare. We screened title/abstracts and full text to identify studies using experimental vignettes to examine drivers of variations in healthcare delivery. Included papers were assessed against a methodological framework synthesised from vignette study design recommendations within and beyond healthcare. RESULTS: We located 21 eligible studies. Study participants were almost exclusively clinicians (18/21). Vignettes were delivered via text (n = 6), pictures (n = 6), video (n = 6) or interactively, using face-to-face, telephone or online simulated consultations (n = 3). Few studies evaluated the credibility of vignettes, and many had flaws in their wider study design. Ten were of good methodological quality. Studies contributed to understanding variations in care, most commonly by testing hypotheses that could not be examined directly using real patients. CONCLUSIONS: Experimental vignette studies can be an important methodological tool for identifying how unwarranted variations in care can arise. Flaws in study design or conduct can limit their credibility or produce biased results. Their full potential has yet to be realised.

Atenção à Saúde , Envio de Mensagens de Texto , Humanos , MEDLINE , Encaminhamento e Consulta , Telefone
Hypertens Res ; 44(8): 955-968, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-33750913


Angiotensin-converting enzyme 2 (ACE2) protects against organ damage in hypertension and cardiovascular diseases by counter regulating the renin-angiotensin system (RAS). ACE2 is also the receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Based on the claim that RAS inhibitors (RASIs) cause ACE2 overexpression in some animal experiments, concerns have arisen that RASIs may aggravate SARS-CoV-2 infection and coronavirus disease-2019 severity in RASI-treated patients. To achieve a comprehensive review, a systematic search of MEDLINE/PubMed was conducted regarding the effects of RASIs on tissue ACE2 mRNA/protein expression in healthy animals and animal models of human diseases. We identified 88 eligible articles involving 168 experiments in the heart, kidneys, lungs, and other organs. Three of 38 experiments involving healthy animals showed ACE2 expression greater than twice that of the control (overexpression). Among 102 disease models (130 experiments), baseline ACE2 was overexpressed in 16 models (18 experiments) and less than half the control level (repression) in 28 models (40 experiments). In 72 experiments, RASIs did not change ACE2 levels from the baseline levels of disease models. RASIs caused ACE2 overexpression compared to control levels in seven experiments, some of which were unsupported by other experiments under similar conditions. In 36 experiments, RASIs reversed or prevented disease-induced ACE2 repression, yielding no or marginal changes. Therefore, ACE2 overexpression appears to be a rare rather than common consequence of RASI treatment in healthy animals and disease models. Future studies should clarify the pathophysiological significance of RASI-induced reversal or prevention of ACE2 repression in disease models.

Enzima de Conversão de Angiotensina 2/metabolismo , Inibidores da Enzima Conversora de Angiotensina/efeitos adversos , Anti-Hipertensivos/efeitos adversos , Expressão Gênica/efeitos dos fármacos , Inibidores da Enzima Conversora de Angiotensina/farmacologia , Animais , Anti-Hipertensivos/farmacologia , COVID-19 , Modelos Animais de Doenças , MEDLINE , Sistema Renina-Angiotensina/efeitos dos fármacos
Biosci Trends ; 15(2): 64-73, 2021 May 11.
Artigo em Inglês | MEDLINE | ID: mdl-33746182


Coronavirus Disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has affected tens of millions of people globally since it was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. There is an urgent need for safe and effective preventive vaccines to curb this pandemic. A growing amount of related research has been published. This study aimed to provide the current status of COVID-19 vaccine using bibliometric analysis. We searched and MEDLINE comprehensively and included articles, articles in press, reviews, short surveys, conference abstracts and conference papers about COVID-19 vaccine. VOSviewer1.6.11 (Leiden University, Leiden, Netherlands) was applied to perform the bibliometric analysis of these papers. A total of 1,312 papers were finally included. The BMJ has been the most popular journal in this field. The United States maintained a top position worldwide and has provided a pivotal influence, followed by China, India and United Kingdom. Among all the institutions, Harvard University was regarded as a leader for research collaboration. We analyzed the keywords and identified seven COVID-19 vaccine research hotspot clusters. COVID-19 vaccine research hotspots focus on clinical trials on vaccine safety and efficacy, research on vaccine immunology and immunoinformatics, and vaccine hesitancy. Our analysis results demonstrated that cooperation between countries, institutions, and authors were insufficient. The results suggested that clinical trials on vaccine safety, efficacy, immunology, immunoinformatics, production and delivery are research hotspots. Furthermore, we can predict that there will be a lot of research focusing on vaccine adverse reactions.

Bibliometria , Vacinas contra COVID-19 , COVID-19/prevenção & controle , Pandemias/prevenção & controle , SARS-CoV-2 , Pesquisa Biomédica/tendências , COVID-19/epidemiologia , COVID-19/imunologia , Vacinas contra COVID-19/efeitos adversos , Vacinas contra COVID-19/imunologia , Vacinas contra COVID-19/farmacologia , Bases de Dados Bibliográficas , Humanos , MEDLINE , SARS-CoV-2/imunologia , Segurança
Rev. colomb. psiquiatr ; 50(1): 34-38, Jan.-Mar. 2021. tab
Artigo em Espanhol | LILACS, COLNAL | ID: biblio-1251630


RESUMEN Introducción: El conocimiento de la frecuencia de comportamientos zoofílicos en la población general es escaso. Objetivo: Revisar casos, series de casos y estudios de prevalencia de zoofilia en adultos de la población general. Métodos: Se realizó una revisión en las bases de datos de MEDLINE, a través de PubMed, Scopus y la Biblioteca Virtual en Salud de publicaciones desde enero de 2000 hasta diciembre de 2017. Resultados: Se revisaron 13 trabajos (10 informes de casos, 2 series de casos y 1 estudio transversal). Entre los casos se describió a 12 pacientes; las series de casos sumaron a 1.556 personas y el estudio transversal incluyó a 1.015 participantes e informó de una prevalencia de comportamientos zoofílicos del 2%. Conclusiones: Es escasa la información sobre la prevalencia de comportamientos zoofílicos en la población general. Es probable que internet permita investigar mejor estos comportamientos en los próximos años.

ABSTRACT Background: Information about the frequency of zoophilic behaviour in the general population is scarce. Objective: To review cases, case series and prevalence studies of zoophilia in adults in the general population. Methods: A review of publications was carried out in MEDLINE via PubMed, Scopus and the Biblioteca Virtual en Salud [Virtual Health Library] ranging from January 2000 to December 2017. Results: Thirteen papers were reviewed (ten case reports, two case series and one cross-sectional study). Twelve patients were described, the case series totalled 1,556 people and the cross-sectional study included 1,015 participants and reported a prevalence of zoophilic behaviour of 2%. Conclusions: Information on the prevalence of zoophilic behaviour in the general population is limited. The Internet will probably be a valuable tool for further investigating these behaviours in coming years.

Humanos , Masculino , Feminino , Disfunções Sexuais Psicogênicas , Bibliotecas Digitais , População , Volição , Estudos Transversais , MEDLINE , Internet , PubMed , Métodos
BMJ Open ; 11(2): e044143, 2021 02 15.
Artigo em Inglês | MEDLINE | ID: mdl-33589463


INTRODUCTION: Cluster randomised trials (CRTs) are studies in which groups (clusters) of participants rather than the individuals themselves are randomised to trial arms. CRTs are becoming increasingly relevant for evaluating interventions delivered in school settings for improving the health of children. Schools are a convenient setting for health interventions targeted at children and the CRT design respects the clustered structure in schools (ie, pupils within classrooms/teachers within schools). Some of the methodological challenges of CRTs, such as ethical considerations for enrolment of children into trials and how best to handle the analysis of data from participants (pupils) that change clusters (schools), may be more salient for the school setting. A better understanding of the characteristics and methodological considerations of school-based CRTs of health interventions would inform the design of future similar studies. To our knowledge, this is the only systematic review to focus specifically on the characteristics and methodological practices of CRTs delivered in schools to evaluate interventions for improving health outcomes in pupils in the UK. METHODS AND ANALYSIS: We will search for CRTs published from inception to 30 June 2020 inclusively indexed in MEDLINE (Ovid). We will identify relevant articles through title and abstract screening, and subsequent full-text screening for eligibility against predefined inclusion criteria. Disagreements will be resolved through discussion. Two independent reviewers will extract data for each study using a prepiloted data extraction form. Findings will be summarised using descriptive statistics and graphs. ETHICS AND DISSEMINATION: This methodological systematic review does not require ethical approval as only secondary data extracted from papers will be analysed and the data are not linked to individual participants. After completion of the systematic review, the data will be analysed, and the findings disseminated through peer-reviewed publications and scientific meetings. PROSPERO REGISTRATION NUMBER: CRD42020201792.

Avaliação de Resultados em Cuidados de Saúde , Instituições Acadêmicas , Criança , Humanos , MEDLINE , Ensaios Clínicos Controlados Aleatórios como Assunto , Revisões Sistemáticas como Assunto , Reino Unido
Syst Rev ; 10(1): 38, 2021 01 23.
Artigo em Inglês | MEDLINE | ID: mdl-33485394


BACKGROUND: Systematic reviews involve searching multiple bibliographic databases to identify eligible studies. As this type of evidence synthesis is increasingly pursued, the use of various electronic platforms can help researchers improve the efficiency and quality of their research. We examined the accuracy and efficiency of commonly used electronic methods for flagging and removing duplicate references during this process. METHODS: A heterogeneous sample of references was obtained by conducting a similar topical search in MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and PsycINFO databases. References were de-duplicated via manual abstraction to create a benchmark set. The default settings were then used in Ovid multifile search, EndNote desktop, Mendeley, Zotero, Covidence, and Rayyan to de-duplicate the sample of references independently. Using the benchmark set as reference, the number of false-negative and false-positive duplicate references for each method was identified, and accuracy, sensitivity, and specificity were determined. RESULTS: We found that the most accurate methods for identifying duplicate references were Ovid, Covidence, and Rayyan. Ovid and Covidence possessed the highest specificity for identifying duplicate references, while Rayyan demonstrated the highest sensitivity. CONCLUSION: This study reveals the strengths and weaknesses of commonly used de-duplication methods and provides strategies for improving their performance to avoid unintentionally removing eligible studies and introducing bias into systematic reviews. Along with availability, ease-of-use, functionality, and capability, these findings are important to consider when researchers are selecting database platforms and supporting software programs for conducting systematic reviews.

Armazenamento e Recuperação da Informação , Revisões Sistemáticas como Assunto , Bases de Dados Bibliográficas , Humanos , MEDLINE
Syst Rev ; 10(1): 15, 2021 01 08.
Artigo em Inglês | MEDLINE | ID: mdl-33419451


BACKGROUND: The development of questionnaires for primary care practice and research is of increasing interest in the literature. In settings where valuable prior knowledge or preliminary data is available, Bayesian factor analysis can be used to incorporate such information when conducting questionnaire construct validation. This protocol outlines a methodological review that will summarize evidence on the current use of Bayesian factor analysis in the primary care literature. METHODS: A comprehensive search strategy has been developed and will be used to identify relevant literature (research studies in primary care) indexed in MEDLINE, Scopus, EMBASE, CINAHL, and Cochrane Library. The search strategy includes terms and synonyms for Bayesian factor analysis and primary care. The reference lists of relevant articles being identified will be screened to find further relevant studies. At least two reviewers will independently extract data and resolve discrepancies through consensus. Descriptive analyses will summarize the use and reporting of Bayesian factor analysis approaches for validating questionnaires applicable to primary care. DISCUSSION: This methodological review will provide a comprehensive overview of the current use and reporting of Bayesian factor analysis in primary care and will provide recommendations for its proper future use. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42018114978.

Atenção à Saúde , Atenção Primária à Saúde , Teorema de Bayes , Análise Fatorial , Humanos , MEDLINE , Literatura de Revisão como Assunto
Rev. enferm. UFPE on line ; 15(1): [1-14], jan. 2021. ilus, tab, graf
Artigo em Português | BDENF - Enfermagem | ID: biblio-1146755


Objetivo: identificar as medidas preventivas para lesões por pressão causadas pelo uso dos equipamentos de proteção individual durante a pandemia da COVID-19. Método trata-se de um estudo bibliográfico, descritivo, tipo revisão integrativa cuja busca ocorreu nas bases de dados LILACS, MEDLINE e Biblioteca Virtual SCIELO. Incluíram-se artigos originais, publicados entre 2019 e 2020, nos idiomas inglês e português. Analisaram-se os achados de forma descritiva. Resultados: identificaram-se 203 estudos publicados em periódicos nacionais e internacionais. Selecionaram-se 15 estudos, que avaliam a técnica de utilização dos equipamentos de proteção individual e estudos que oferecem vários tipos de cobertura/dispositivos e medidas preventivas para lesão causada pelo equipamento de proteção individual. Conclusão: faz-se necessário, com a exposição dos profissionais da saúde à COVID-19, que seja feita recomendação no sentido de que os gestores das instituições implementem protocolos e que os profissionais sejam treinados relativamente às técnicas corretas do uso do equipamento de proteção individual e sobre as medidas preventivas para lesões causadas pelo uso do equipamento de proteção individual e relacionadas aos cuidados com a pele antes da colocação e após a retirada desses equipamentos.(AU)

Objective: to identify preventive measures for pressure injuries caused by the use of personal protective equipment during the COVID-19 pandemic. Method: this is a bibliographic, descriptive, integrative review-type study whose search took place in the LILACS, MEDLINE and SCIELO Virtual Library databases. Original articles published between 2019 and 2020 in English and Portuguese were included. The findings were analyzed in a descriptive manner. Results: two hundred and three studies published in national and international journals were identified. Fifteen studies were selected, which evaluate the technique of using personal protective equipment and studies that offer various types of coverage/devices and preventive measures for injury caused by personal protective equipment. Conclusion: it is necessary, with the exposure of health professionals to COVID-19, to recommend that the managers of the institutions implement protocols and that the professionals be trained on the correct techniques for the use of personal protective equipment and on preventive measures for injuries caused by the use of personal protective equipment and related to skin care before the placement and after the removal of this equipment.(AU)

Objetivo: identificar las medidas preventivas para las lesiones por presión causadas por el uso de equipo de protección personal durante la pandemia del COVID-19. Método: se trata de un tipo de revisión bibliográfica, descriptiva, integradora cuya búsqueda se realizó en las bases de datos LILACS, MEDLINE y Biblioteca Virtual SCIELO. Se incluyeron artículos originales, publicados entre 2019 y 2020, en inglés y portugués. Los hallazgos se analizaron de forma descriptiva. Resultados: se identificaron 203 estudios publicados en revistas nacionales e internacionales. Se seleccionaron quince estudios, que evalúan la técnica de uso de equipos de protección personal y estudios que ofrecen diversos tipos de coberturas / dispositivos y medidas preventivas para las lesiones causadas por equipos de protección personal. Conclusión: es necesario, con la exposición de los profesionales de la salud al COVID-19, que se haga una recomendación en el sentido de que los gerentes de las instituciones implementen protocolos y que los profesionales estén capacitados en las técnicas correctas para el uso de equipos de protección personal y sobre las medidas preventivas para lesiones causadas por el uso de equipo de protección personal y relacionadas con el cuidado de la piel antes de colocar y después de retirar dicho equipo.(AU)

Humanos , Masculino , Feminino , Pessoal de Saúde , Infecções por Coronavirus , Lesão por Pressão , Lesão por Pressão/prevenção & controle , Vírus da SARS , Equipamento de Proteção Individual , Equipe de Enfermagem , Epidemiologia Descritiva , MEDLINE , LILACS
Rev. enferm. UFPE on line ; 15(1): [1-14], jan. 2021. ilus, tab
Artigo em Português | BDENF - Enfermagem | ID: biblio-1147663


Objetivo: identificar os Diagnósticos de Enfermagem que estão publicados na literatura relacionados ao alojamento conjunto. Método: trata-se de um estudo bibliográfico, descritivo, tipo revisão integrativa, com busca nas bases de dados: LILACS, MEDLINE e na Biblioteca Virtual SciELO. Utilizaram-se os descritores "Puerpério", "Diagnóstico de Enfermagem" e "Processo de Enfermagem" associados pelo marcador booleano AND. Estabeleceram-se como critérios de inclusão: estudos originais, publicados na íntegra, no período de 2010 a 2020 e nos idiomas português, inglês e espanhol. Analisaram-se os dados de forma descritiva. Resultados: constituiu-se a amostra por três artigos que apresentaram os seguintes Diagnósticos de Enfermagem relacionados ao alojamento conjunto, utilizando-se a taxonomia II da NANDA-I: amamentação eficaz; amamentação ineficaz; risco de infecção; risco de desequilíbrio na temperatura corporal e conforto prejudicado. Conclusão: aponta-se que este estudo possibilitou identificar os Diagnósticos de Enfermagem mais comuns no alojamento conjunto, contribuindo para o fortalecimento do Processo de Enfermagem.(AU)

Objective: to identify the Nursing Diagnostics that are published in the literature related to the joint housing. Method: it is a bibliographic, descriptive, integrative review type study, with search in the databases: LILACS, MEDLINE and SciELO Virtual Library. The descriptors "Puerperium", "Nursing Diagnosis" and "Nursing Process" associated with the Boolean marker AND were used. The following were established as inclusion criteria: original studies, published in full, from 2010 to 2020 and in Portuguese, English and Spanish. The data was analyzed in a descriptive manner. Results: The sample consisted of three articles that presented the following Nursing Diagnostics related to the joint accommodation, using the NANDA-I taxonomy II: effective breastfeeding; ineffective breastfeeding; risk of infection; risk of imbalance in body temperature and impaired comfort. Conclusion: it is pointed out that this study made it possible to identify the most common Nursing Diagnostics in the joint accommodation, contributing to the strengthening of the Nursing Process.(AU)

Objetivo: identificar los Diagnósticos de Enfermería publicados en la literatura relacionados com el alojamiento conjunto. Método: se trata de un estudio bibliográfico, descriptivo, tipo revisión integradora, con búsqueda en las bases de datos: LILACS, MEDLINE y Biblioteca Virtual SciELO. Se utilizaron los descriptores "Puerperio", "Diagnóstico de Enfermería" y "Proceso de Enfermería" asociados al marcador booleano AND. Fueron establecidos como criterios de inclusión: estudios originales, publicados íntegramente, de 2010 a 2020 y en portugués, inglés y español. Los datos se analizaron de forma descriptiva. Resultados: la muestra estuvo compuesta por tres artículos que presentaron los siguientes Diagnósticos de Enfermería relacionados con el alojamiento conjunto, utilizando la taxonomía NANDA-I II: lactancia materna efectiva; lactancia materna ineficaz; riesgo de infección; riesgo de desequilibrio en la temperatura corporal y deterioro del confort. Conclusión: se señala que este estudio permitió identificar los Diagnósticos de Enfermería más comunes en el alojamiento conjunto, contribuyendo al fortalecimiento del Proceso de Enfermería.(AU)

Humanos , Feminino , Gravidez , Recém-Nascido , Alojamento Conjunto , Diagnóstico de Enfermagem , Período Pós-Parto , Relações Mãe-Filho , Cuidados de Enfermagem , Processo de Enfermagem , Epidemiologia Descritiva , MEDLINE , LILACS , Terminologia Padronizada em Enfermagem
Rev. enferm. UFPE on line ; 15(1): [1-15], jan. 2021. ilus, tab, graf
Artigo em Português | BDENF - Enfermagem | ID: biblio-1147672


Objetivo: identificar os fatores de risco e as formas de prevenção da pneumonia em pacientes hospitalizados por trauma em Unidades de Terapia Intensiva. Método: trata-se de um estudo bibliográfico, descritivo, tipo revisão integrativa de literatura de artigos pesquisados publicados nos últimos dez anos na Biblioteca Virtual de Saúde e nas bases de dados MEDLINE e LILACS. Selecionaram-se, como descritores dispostos no portal de Descritores das Ciências da Saúde. Realizou-se a análise descritiva dos resultados a partir dos dados encontrados. Resultados: apontase que um total de dez artigos atendeu aos critérios de seleção. Ressalta-se que as medidas de prevenção mais relevantes observadas foram a descontaminação oral com clorexidina a 2% feita precocemente, a realização de exames de cultura microbiológica, antibiograma e descalonamento/escalonamento de antibióticos. Conclusão: conclui-se que a maioria dos fatores de risco para o desenvolvimento da pneumonia encontrados no estudo estava relacionada a consequências do trauma e intervenções realizadas durante a internação. Avalia-se que as principais medidas de prevenção são de fácil execução e baixo custo.(AU)

Objective: to identify risk factors and ways of preventing pneumonia in patients hospitalized for trauma in Intensive Care Units. Method: This is a bibliographic, descriptive, integrative literature review type study of researched articles published in the last ten years in the Virtual Health Library and in the MEDLINE and LILACS databases. They were selected, as descriptors arranged in the Health Sciences Descriptors portal. The descriptive analysis of the results from the data found was carried out. Results: It is pointed out that a total of ten articles met the selection criteria. The most relevant prevention measures observed were oral decontamination with 2% chlorhexidine done early, microbiological culture tests, anti-biogram and antibiotic de-escalation/escalation. Conclusion: It is concluded that most of the risk factors for the development of pneumonia found in the study were related to consequences of trauma and interventions performed during hospitalization. It is evaluated that the main prevention measures are easy to carry out and low cost.(AU)

Objetivo: identificar factores de riesgo y formas de prevención de la neumonía en pacientes hospitalizados por trauma en Unidades de Cuidados Intensivos. Método: se trata de una revisión bibliográfica, descriptiva, integradora de la literatura de los artículos investigados publicados en los últimos diez años en la Biblioteca Virtual en Salud y en las bases de datos MEDLINE y LILACS. Fueron seleccionados como descriptores disponibles en el portal de Descriptores de Ciencias de la Salud. Se realizó un análisis descriptivo de los resultados a partir de los datos encontrados. Resultados: se señala que un total de diez artículos cumplieron los criterios de selección. Cabe destacar que las medidas preventivas más relevantes observadas fueron la descontaminación oral con clorhexidina al 2% realizada precozmente, la realización de pruebas de cultivo microbiológico, antibiograma y desescalamiento / escalado antibiótico. Conclusión: se concluye que la mayoría de los factores de riesgo para el desarrollo de neumonía encontrados en el estudio estuvieron relacionados con las consecuencias del trauma y las intervenciones realizadas durante la hospitalización. Se estima que las principales medidas preventivas son fáciles de implementar y de bajo costo.(AU)

Humanos , Masculino , Feminino , Pneumonia , Ferimentos e Lesões , Fatores de Risco , Pneumonia Associada à Ventilação Mecânica/prevenção & controle , Pneumonia Associada a Assistência à Saúde/prevenção & controle , Hospitalização , Unidades de Terapia Intensiva , Epidemiologia Descritiva , MEDLINE , LILACS