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1.
Medicine (Baltimore) ; 99(2): e18069, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31914012

RESUMO

This study aims to find and locate foramens exactly in maxilla and mandible in case of complications during surgeries.Computer topographic angiography (CTA) images of 120 cases were reviewed. The measurements were performed on coronal, sagittal and axial planes after the 3 dimension volume reconstruction. The distances among foramens, bony landmarks, teeth, and facial artery were all measured with the angles as adjustments.The incisive foramen (IF) was measured 20.55 ±â€Š2.81 mm to margo inferior of incisor, and 45.27 ±â€Š5.27 degree from the axial midline. The greater palatine foramen located 43.17 ±â€Š2.55 mm from the IF, while 21.08 ±â€Š3.75 degree from the midline in axial plane. The lesser palatine foramina located 44.56 ±â€Š5.74 mm from the IF and 20.05 ±â€Š3.59 degree to the midline. The Mandibular foramen (MBF) was 91.15 ±â€Š1.86 mm horizontally to the margo inferior of incisor. The angle that the MBF-margo inferior of incisor line made with the axial midline was 31.25 ±â€Š2.89 degree. The shortest horizontal distance from the mental foramen (MF) to the facial artery in sagittal plane was 21.90 ±â€Š1.86 mm, while it became 13.00 ±â€Š2.05 mm in coronary section. The horizontal distance from the MF to the margo inferior of incisor in sagittal plane was 22.04 ±â€Š3.22 mm. It turned out to be 25.78 ±â€Š5.23 mm between MF and mid-sagittal line in coronary section. The vertical distance was 25.20 ±â€Š3.06 mm from the upper margin of the second premolar to the MF.The foramens were clearly seen through CTA. Moreover, linear and angular measurements were presented, which makes it safer and wiser for surgeons to consider the biometric data before operations.


Assuntos
Pontos de Referência Anatômicos/diagnóstico por imagem , Angiografia por Tomografia Computadorizada/métodos , Mandíbula/anatomia & histologia , Forame Mentual/diagnóstico por imagem , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Artérias , Osso e Ossos/diagnóstico por imagem , Osso e Ossos/cirurgia , Criança , Face/irrigação sanguínea , Face/diagnóstico por imagem , Feminino , Humanos , Incisivo/anatomia & histologia , Incisivo/diagnóstico por imagem , Masculino , Mandíbula/diagnóstico por imagem , Mandíbula/patologia , Mandíbula/cirurgia , Forame Mentual/cirurgia , Pessoa de Meia-Idade , Adulto Jovem
2.
J Forensic Sci ; 65(1): 304-313, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31145812

RESUMO

In 1949, the American Graves Registration Service Pacific Zone proposed the identification of 27 sets of remains (skulls/crania/mandibles) based on comparisons with written dental records. All were denied, and the remains were buried as unknowns. In 2003 and 2015, the remains were exhumed by the DPAA. Currently, 26 individuals previously recommended for identification have been positively identified. The DPAA Science Director's opinion corresponded with 24 of their recommendations, while DNA excluded three. Caution should be taken by the forensic scientist when building assemblages through skeletal and dental articulation. The forensic odontologist must always consider variations in restorative care/extraction patterns and the possibility of documentation errors when reviewing/interpreting historical and current day dental records used for AM/PM comparisons. The odontologist should base their opinion on the strength of the antemortem/postmortem comparison, number and type of concordances, and distinct dental care and extraction patterns.


Assuntos
Restos Mortais , Registros Odontológicos , Odontologia Legal/métodos , Amálgama Dentário , Prótese Dentária , Exumação , História do Século XX , Humanos , Mandíbula/patologia , Maxila/patologia , Militares/história , Fotografação , Radiografia Dentária , Dente/patologia , Estados Unidos , II Guerra Mundial
3.
Oral Dis ; 26(1): 12-21, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30614154

RESUMO

OBJECTIVES: To evaluate the global incidence of ameloblastoma and to provide a profile of ameloblastoma patients. MATERIAL AND METHODS: A systematic review and meta-analysis was conducted. Searches were performed in PubMed, EMBASE, SCOPUS, and Web of Science for articles published from 1969 to 2018 for the global incidence and from 1995 to 2018 for the profile of ameloblastoma patients. RESULTS: Seven studies on the incidence rate of ameloblastoma were included in the meta-analysis. These studies only covered Europe, Africa, and Australia. The pooled incidence rate was 0.92 per million person-years (95% CI: 0.57-1.49), with significant heterogeneity between studies. Forty-two articles provided profile data of 6,446 ameloblastoma patients. Mean age was 34 years and the peak age incidence in the third decade of life. In Europe and North America, ameloblastoma mostly occurred at an older age when compared to Africa and South America. A slight male preference (53%) was found, and the mandible appeared to be the preferred site. The most common type of ameloblastoma was multicystic. The histopathologic patterns were mostly follicular and plexiform. CONCLUSIONS: This is the first study assessing the global incidence of ameloblastoma. The pooled incidence rate was determined to be 0.92 per million person-years.


Assuntos
Ameloblastoma/epidemiologia , Neoplasias Maxilomandibulares/epidemiologia , África , Austrália , Europa (Continente) , Humanos , Incidência , Mandíbula/patologia
4.
J Craniofac Surg ; 31(1): e75-e78, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31634309

RESUMO

OBJECTIVE: This article describes the case report of a prostate adenocarcinoma in the mandible. BACKGROUND: Prostate adenocarcinoma is a malignant tumor common in men from the fourth decade of life. The occurrence of oral metastatic lesions is rare. CASE REPORT: A 78-year-old male patient was referred to the oral and maxillofacial surgery service of the Pontifical Catholic University of Rio Grande do Sul for complaints of painless volume increase in the mandible. The diagnosis through the association of clinical, radiographic, and histopathological examination with the patient's health history determined that the lesion was prostatic adenocarcinoma metastasis. CONCLUSION: Despite the rare occurrence of metastases in the oral region, the dental surgeon should be aware of the possibility for correct diagnostic conduction and, subsequently, the institution of treatment in the early stages of disease.


Assuntos
Adenocarcinoma/secundário , Maxila/patologia , Neoplasias da Próstata/patologia , Idoso , Humanos , Masculino , Mandíbula/patologia
5.
Toxicol Lett ; 319: 250-255, 2020 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-31778774

RESUMO

The effect of thalidomide on mandibular development is unclear. In this study, thalidomide was delivered to pregnant rabbits from the 8th to 14th day of gestation. Then, embryos were harvested for examination on the 16th day (GD16), 20th day (GD20) and 24th day (GD24) of gestation. The results showed obvious hemorrhage and hematoma on one side of the craniofacial region in 50 % of the thalidomide-treated embryos and obvious hemorrhage and hematoma on both sides of the craniofacial region in 50 % of the thalidomide-treated embryos at GD16. Histological examination showed soft tissues and mandible defects on the affected side of the maxillofacial region. The expression of Vegf-α, Ki67 and Sox9 on the affected side was significantly down-regulated in comparison to their expression on the unaffected side at GD20. There was also an obvious defect in the affected mandible, and the density of the skull and mandible was decreased compared to the unaffected side or the control group at GD24. These findings demonstrated that thalidomide may lead to hemorrhage and hematoma in the craniofacial region by inhibiting angiogenesis, resulting in the abnormal development of cranial neural crest cells that are involved in the normal development of the mandible in rabbits.


Assuntos
Anormalidades Craniofaciais/induzido quimicamente , Anormalidades Craniofaciais/patologia , Hemorragia/induzido quimicamente , Hemorragia/patologia , Mandíbula/patologia , Neovascularização Fisiológica/efeitos dos fármacos , Teratogênios/toxicidade , Talidomida/toxicidade , Animais , Regulação para Baixo/efeitos dos fármacos , Feminino , Mandíbula/anormalidades , Anormalidades Maxilofaciais/induzido quimicamente , Anormalidades Maxilofaciais/patologia , Crista Neural/patologia , Gravidez , Coelhos , Crânio/anormalidades
6.
J Craniofac Surg ; 31(1): e81-e82, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31652213

RESUMO

The authors report a rare case of intraosseous hemangioma of the mandible in a 14-year-old male. Surgical intervention with embolization is as important as histological and radiological examination to reduce the bleeding complication. Magnetic resonance angiography is paramount of importance in these lesions to detect the supplier arteries.


Assuntos
Hemangioma/cirurgia , Mandíbula/cirurgia , Crânio/anormalidades , Coluna Vertebral/anormalidades , Malformações Vasculares/cirurgia , Adolescente , Embolização Terapêutica , Hemangioma/patologia , Humanos , Masculino , Mandíbula/patologia , Procedimentos Cirúrgicos Reconstrutivos , Crânio/patologia , Crânio/cirurgia , Coluna Vertebral/patologia , Coluna Vertebral/cirurgia , Malformações Vasculares/patologia
7.
Ann R Coll Surg Engl ; 102(3): e75-e76, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31850797

RESUMO

Giant cell reparative granuloma is an unusual benign process arising especially in the maxillofacial bones. It occurs in the second and third decades, predominantly in children and young adults, and is classified as peripheral (located in gingival tissues) and central (located in bone). We presented an unusual case with a lytic and aggressive radiological appearance.


Assuntos
Granuloma de Células Gigantes/diagnóstico por imagem , Doenças Mandibulares/diagnóstico por imagem , Adulto , Biópsia , Granuloma de Células Gigantes/patologia , Humanos , Imagem por Ressonância Magnética , Masculino , Mandíbula/patologia , Doenças Mandibulares/patologia , Tomografia Computadorizada Multidetectores
9.
J Craniomaxillofac Surg ; 47(12): 1922-1928, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31810841

RESUMO

Non-surgical therapy has proved to be effective in chronic diffuse sclerosing osteomyelitis (DSO) of the mandible in children. Therefore we aimed to investigate the effect of non-surgical therapy in adult DSO patients. We included consecutive patients with DSO who received non-surgical therapy in our center. They all received occlusal splint therapy, counselling about the disease, and/or physiotherapy by a specialised team. The use of analgesics, preferably nonsteroidal anti-inflammatory drugs, was advised for symptomatic control during periods of exacerbation. Sixteen patients (11/5 female/male) aged 39.9 ± 15.0 years with DSO of the mandible were included. The mean duration of symptoms was 39.7 ± 26.3 months before referral to our center. Patients were treated with a broad range of treatments before referral. All patients underwent non-surgical treatment. In 12 patients this led to remission. Four patients still had complaints after 12 months of non-surgical therapy and started with intravenous bisphosphonate therapy. In our center, DSO of the mandible was successfully treated with non-surgical therapy, despite a long duration before referral and extensive pre-treatment. Considering this high success rate, we recommend this non-surgical approach as the first treatment option for DSO of the mandible. In case of persistence, alternative treatments such as bisphosphonates should be explored.


Assuntos
Conservadores da Densidade Óssea/uso terapêutico , Tratamento Conservador/métodos , Difosfonatos/uso terapêutico , Doenças Mandibulares/terapia , Placas Oclusais , Osteomielite/terapia , Dor/tratamento farmacológico , Periostite/terapia , Adulto , Criança , Doença Crônica , Feminino , Humanos , Masculino , Mandíbula/patologia , Doenças Mandibulares/complicações , Pessoa de Meia-Idade , Osteomielite/complicações , Dor/etiologia , Periostite/complicações , Resultado do Tratamento , Adulto Jovem
10.
Tissue Eng Part C Methods ; 25(12): 721-731, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31850839

RESUMO

Angiogenesis is a critical process essential for optimal bone healing. Several in vitro and in vivo systems have been previously used to elucidate some of the mechanisms involved in the process of angiogenesis, and at the same time, to test potential therapeutic agents and bioactive factors that play important roles in neovascularization. Computed tomography (CT) is a noninvasive imaging technique that has recently allowed investigators to obtain a diverse range of high-resolution, three-dimensional characterization of structures, such as bone formation within bony defects. Unfortunately, to date, angiogenesis evaluation relies primarily on histology, or ex vivo imaging and few studies have utilized CT to qualitatively and quantitatively study the vascular response during bone repair. In the current study a clinical CT-based technique was used to evaluate the effects of rhBMP-2 eluting graft treatment on soft tissue vascular architecture surrounding a large segmental bone defect model in the minipig mandible. The objective of this study was to demonstrate the efficacy of contrast-enhanced, clinical 64-slice CT technology in extracting quantitative metrics of vascular architecture over a 12-week period. The results of this study show that the presence of rhBMP-2 had a positive effect on vessel volume from 4 to 12 weeks, which was explained by a concurrent increase in vessel number, which was also significantly higher at 4 weeks for the rhBMP-2 treatment. More importantly, analysis of vessel architecture showed no changes throughout the duration of the study, indicating therapeutic safety. This study validates CT analysis as a relevant imaging method for quantitative and qualitative analysis of morphological characteristics of vascular tissue around a bone healing site. Also important, the study shows that CT technology can be used in large animal models and potentially be translated into clinical models for the development of improved methods to evaluate tissue healing and vascular adaptation processes over the course of therapy. This methodology has demonstrated sensitivity to tracking spatial and temporal changes in vascularization and has the potential to be applied to studying changes in other high-contrast tissues as well. Impact Statement Tissue engineering solutions depend on the surrounding tissue response to support regeneration. The inflammatory environment and surrounding vascular supply are critical to determining if therapies will survive, engraftment occurs, and native physiology is restored. This study for the first time evaluates the blood vessel network changes in surrounding soft tissue to a bone defect site in a large animal model, using clinically available computed tomography tools and model changes in vessel number, size, and architecture. While this study focuses on rhBMP2 delivery impacting surrounding vasculature, this validated method can be extended to studying the vascular network changes in other tissues as well.


Assuntos
Proteína Morfogenética Óssea 2/farmacologia , Regeneração Óssea/efeitos dos fármacos , Mandíbula , Traumatismos Mandibulares , Animais , Implantes de Medicamento/farmacologia , Humanos , Mandíbula/irrigação sanguínea , Mandíbula/metabolismo , Mandíbula/patologia , Traumatismos Mandibulares/metabolismo , Traumatismos Mandibulares/patologia , Traumatismos Mandibulares/terapia , Proteínas Recombinantes/farmacologia , Suínos , Porco Miniatura
11.
Georgian Med News ; (294): 145-150, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31687968

RESUMO

The main aim is to find out the mechanisms of reparative regeneration of bone tissue in artificially created transverse mandibular defects in rats when applying osteoplastic materials based on hydroxyapatite and polylactide with different component percentage. Experimental studies were carried out on 114 mature laboratory white male 180-220 g rats that were divided into groups: control group - animals whose bone defect was filled only with a blood clot; 1st experimental group - the entire defect volume was densely filled with a block with the ratio of component parts, hydroxyapatite 80% + polylactide 20%; 2nd experimental group was similar, but with the ratio of 50% + 50%. Morphological and morphometric research methods were carried out after the removed jaws had been decalcized in a 10% nitric acid solution. An x-ray study was performed using an Intra digital radiograph (Planmeca, Finland). Statistical analysis of the results was carried out according to the standard method of descriptive statistics using the software package "StatSoftStatistica 10". The use of osteoplastic material with a longer period of its biodegradation contributes to filling the defect with bone tissue, but slows down the processes of the final formation of a mature secondary bone scar, yet allows even with hypercorrection to restore the anatomical form of the lost area. Therefore, the use of this material is recommended for a defect in the alveolar ridge, mainly in extraction sockets, when one needs to avoid atrophy and to create conditions for prosthetic treatment. Osteoimplant with a faster biodegradation period allows structuring collagen fibers in the regenerate in the early stages of healing, which optimizes the formation of an organic bone matrix and promotes its faster mineralization. Therefore, such bone substitutes can be better used for insignificant defects or when the restoration of the anatomical form is not essential, mainly for defects of the body and mandibular branches.


Assuntos
Perda do Osso Alveolar/tratamento farmacológico , Materiais Biocompatíveis/uso terapêutico , Regeneração Óssea/efeitos dos fármacos , Substitutos Ósseos/farmacologia , Mandíbula/patologia , Poliésteres/farmacologia , Perda do Osso Alveolar/cirurgia , Animais , Substitutos Ósseos/uso terapêutico , Durapatita , Masculino , Mandíbula/cirurgia , Ratos , Cicatrização
13.
J Craniofac Surg ; 30(8): 2530-2532, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31609960

RESUMO

Osteogenesis imperfecta (OI) is characterized by brittle bones, premature hearing loss, blue sclera, dental abnormalities, and short stature. Maxillofacial pathology is marked in many OI patients and includes a high incidence of class III malocclusion secondary to a retrusive maxilla relative to both the mandible and cranial base.Review of literature shows that most of the orthognathic surgeries performed in the setting of OI are double jaw surgeries, in the form of maxillary advancement and mandibular setback. However, severe maxillary hypoplasia is usually not correctable with single-stage maxillary advancement. Distraction osteogenesis (DO) is a technique that relies on the normal healing process that occurs between controlled, surgically osteotomized bone segments and it is a relatively widely used technique in modern management of craniofacial conditions.Distraction osteogenesis has been reported in only several patients with OI. There is only 1 previously documented case of maxillary distraction in the craniofacial literature. The authors present here the successful management of a patient with OI and severe class III malocclusion using LeFort I osteotomy and DO with an external rigid distractor.At 12 months follow-up, the patient had no complications and maintained stable maxillary position with normal occlusion, improvement of facial appearance, obstructive airway symptoms, speech, and chewing.This case serves to reinforce the safety and efficacy of DO in patients with OI. The authors did not significantly change our distraction protocol and did not have any complications, therefore the authors believe that DO should be the preferable treatment technique for severe malocclusion in OI patient population.


Assuntos
Osteogênese Imperfeita/cirurgia , Osteogênese por Distração , Adolescente , Humanos , Masculino , Mandíbula/patologia , Maxila/cirurgia , Procedimentos Cirúrgicos Ortognáticos/métodos , Osteogênese por Distração/métodos
14.
Anticancer Res ; 39(10): 5689-5693, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31570468

RESUMO

BACKGROUND/AIM: To evaluate the association between osteoradionecrosis (ORN) of the mandible and stenosis of the external carotid artery after radiation therapy (RT) for head and neck cancer. PATIENTS AND METHODS: The computed tomography images of 42 patients (36 men, six women; median age, 64.5 years) treated with RT for head and neck cancer between January 2011 and December 2015 were reviewed. The cross-sectional diameters of the bilateral external carotid arteries were measured on contrast-enhanced images taken after completion of RT. RESULTS: Nine of the 42 included patients (21.4%) developed ORN after a median interval of 34 months from completion of RT. Univariate analysis revealed that external carotid artery diameter ≤ the median diameter was significantly associated with ORN development (p=0.008 and 0.013). In multivariate analysis, left external carotid artery diameter ≤ the median was significantly associated with ORN development (p=0.023). CONCLUSION: External carotid artery stenosis was significantly associated with ORN development.


Assuntos
Artéria Carótida Externa/patologia , Mandíbula/patologia , Osteorradionecrose/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Estenose das Carótidas/patologia , Estudos Transversais , Feminino , Neoplasias de Cabeça e Pescoço/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Dosagem Radioterapêutica , Fatores de Risco
15.
J Craniomaxillofac Surg ; 47(11): 1665-1675, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31473057

RESUMO

PURPOSE: To investigate the morphological features of hemimandibular hyperplasia (HH) in comparison to other condylar hyperplasia-associated asymmetries, including hemimandibular elongation (HE), solitary condylar hyperplasia (SCH), simple mandibular asymmetry (SMA) and condylar osteoma or osteochondroma (COS). MATERIALS AND METHODS: A total of 31 HH, 9 HE, 6 SCH, 10 SMA and 10 COS patients were included in this study. Clinical documentation, panoramic radiography and computed tomography data were retrospectively reviewed. The three-dimensional measurements were performed on multi-planar reformation images and volume rendering images. The accuracy of the subjective radiological signs was evaluated using sensitivity, specificity and receiver operating curve analysis. Discriminant analysis was performed to generate predictive formulas using quantitative data. RESULTS: The condyles in HH were regularly or irregularly enlarged, with significantly enlarged anterior-posterior length [16.2/5.29 (mean/SD, mm) P < 0.001] and volume [5.3/2.9(mean/SD, cm3) P < 0.001] compared to the normal values. The condyles in HE and SMA were normally shaped, and the quantitative measurements were within the normal range. The ramus heights in the HH patients [55.7/5.4(mean/SD, mm)] were enlarged in comparison to the contralateral side (P < 0.001) and normal values (P < 0.001). The ramus heights in the HE [52.4/7.1 (mean/SD, mm), P < 0.001] and SMA [50.3/5.0(mean/SD, mm), P = 0.002] patients were enlarged in the contralateral side comparison but were within the normal range. The mandibular body heights in HH were enlarged in the premolar [16.6/1.3 (mean/SD, mm), P < 0.001] and molar [24.8/1.4 (mean/SD, mm), P < 0.001] regions. The inferior convexity of the lower mandibular border and inferiorly displaced mandibular canal produced high specificity, sensitivity and area under the curve for the diagnosis of HH. Discriminant analysis could predict the diagnoses with a cross-validation accuracy rate of 85.7%. CONCLUSIONS: HH is a distinct clinical entity characterized by enlargement of the condyle, ramus and mandibular body. The inferior convexity of the lower mandibular border and inferiorly displaced mandibular canal is accurate and specific for the diagnosis of HH. The condyles in HE are not hyperplastic. The term "condylar hyperplasia" alone cannot be used to refer to HH or HE.


Assuntos
Assimetria Facial/diagnóstico , Hiperplasia , Processamento de Imagem Assistida por Computador/métodos , Imageamento Tridimensional/métodos , Mandíbula/anormalidades , Osteocondroma , Osteoma , Humanos , Mandíbula/patologia , Côndilo Mandibular/patologia , Estudos Retrospectivos
16.
J Craniomaxillofac Surg ; 47(11): 1699-1705, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31477439

RESUMO

Various treatments, many of them considerably invasive, are currently applied to infants with Robin sequence (RS) and accompanying upper airway obstruction (UAO). We present a narrative review of our data on the Tübingen palatal plate (TPP) which show the following: a) in a randomized trial, the TPP was superior to a sham procedure in alleviating UAO; b) children treated with the TPP in infancy showed an intellectual development within the reference range; c) prone positioning is no alternative, as it is ineffective and associated with an increased risk of sudden death; d) the TPP reduces the mixed-obstructive apnea index to near-normal values, both in isolated and most (83%) syndromic RS, e) of 443 infants (129 syndromic) treated with the TPP in our center, 23 (5%) ultimately received a tracheostomy (all with syndromic RS), f) recent data suggest that the TPP may induce mandibular catch-up growth, g) the TPP may also help to reduce respiratory complications following cleft closure in RS, and h) TPP treatment is applied by various centers around the world, although it is unclear if its effectiveness is invariably controlled by endoscopy and sleep studies, although both are necessary. Given these data from peer-reviewed studies, it may be questioned whether the "First do no harm" principle is always adhered to when subjecting RS infants to more invasive procedures such as mandibular distraction osteogenesis or tongue-lip adhesion.


Assuntos
Obstrução das Vias Respiratórias/terapia , Osteogênese por Distração , Síndrome de Pierre Robin/terapia , Apneia Obstrutiva do Sono/terapia , Obstrução das Vias Respiratórias/diagnóstico , Obstrução das Vias Respiratórias/etiologia , Criança , Humanos , Lactente , Mandíbula/crescimento & desenvolvimento , Mandíbula/patologia , Síndrome de Pierre Robin/complicações , Síndrome de Pierre Robin/diagnóstico , Síndrome de Pierre Robin/genética , Polissonografia , Estudos Retrospectivos , Apneia Obstrutiva do Sono/diagnóstico , Resultado do Tratamento
17.
Mater Sci Eng C Mater Biol Appl ; 104: 109864, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31499998

RESUMO

Implant-supported dental prosthesis in patients with edentulism or those with reconstructed bone have long survival rate, but the success depends largely on the quality and quantity of the available bone at the recipient site. The usage of autograft is the gold standard treatment for vertical bone augmentation, but it has many limitations. In this study, we have developed a nanocomposite fibrous scaffold [silica coated nanoHA-gelatin reinforced with electrospun poly(L-lactic acid) (PLLA) nanoyarns] and evaluated its efficacy to promote osseointegration in rabbit mandibular defect in comparison to the scaffold without fibers and commercial nanoHA-collagen graft. For this, critical sized bilateral defect (10 mm length, 3 mm depth and 3 mm width) was created in rabbit mandible and dental implantation was done in two manners. In strategy 1, Ti dental implant was placed along with the scaffold and in strategy 2, the scaffold was implanted for 3 months to facilitate new bone formation followed by Ti dental implantation. In strategy 2, the fibrous scaffold could promote new bone formation and osseointegration in rabbit mandibular defect when compared to the scaffolds without fibers and commercial graft, but strategy 1 was not successful. These findings demonstrated that nanocomposite fibrous scaffold is a promising biomaterial to promote new bone formation and osseointegration in mandibular defect.


Assuntos
Implantes Dentários , Mandíbula/patologia , Nanocompostos/química , Osseointegração , Tecidos Suporte/química , Animais , Feminino , Masculino , Osteogênese/efeitos dos fármacos , Coelhos , Titânio/farmacologia
18.
Molecules ; 24(16)2019 Aug 16.
Artigo em Inglês | MEDLINE | ID: mdl-31426356

RESUMO

Halitosis and submandibular abscesses are examples of mouth-related diseases with the possible bacterial origin. Salivary volatile organic compounds (VOCs) are potential biomarkers of them, once they can be addressed as metabolites of bacterial activity. Healthy patients (n = 15), subjects with submandibular abscesses located in fascial deep space (n = 10), and subjects with halitosis (n = 5) were enrolled in the study. Saliva samples were subjected to headspace solid-phase microextraction (HS-SPME) and gas chromatography coupled to mass spectrometry (GC/MS) analysis. A total number of 164 VOCs was detected by the developed methodology, 23 specific for halitosis and 41 for abscess. Halitosis' profiles were characterized by a larger number of sulfur compounds, while for abscess they had a higher variety of alcohols, aldehydes, and hydrocarbons-biomarkers of inflammatory processes. Principal components analysis allowed visualization of clusters formed according to the evaluated conditions. Kruskal-Wallis test indicated that 39 VOCs presented differentiated responses between the studied groups, with statistical relevance (p < 0.05). Random forest was applied, and a prediction model based on eight VOCs (2-butanone, methyl thioacetate, 2-methylbutanoic acid, S-methyl pentanethioate, dimethyl tetrasulfide, indolizine, pentadecane, and octadecanal) provided 100% of sensitivity, 82% of specificity, and 91% of balanced accuracy, indicating the specific presence of submandibular abscess.


Assuntos
Abscesso/diagnóstico , Álcoois/isolamento & purificação , Aldeídos/isolamento & purificação , Halitose/diagnóstico , Hidrocarbonetos/isolamento & purificação , Compostos de Enxofre/isolamento & purificação , Abscesso/metabolismo , Abscesso/patologia , Adulto , Idoso , Álcoois/classificação , Aldeídos/classificação , Biomarcadores/análise , Estudos de Casos e Controles , Giro Denteado/metabolismo , Giro Denteado/patologia , Diagnóstico Diferencial , Feminino , Cromatografia Gasosa-Espectrometria de Massas , Halitose/metabolismo , Halitose/patologia , Humanos , Hidrocarbonetos/classificação , Masculino , Mandíbula/metabolismo , Mandíbula/patologia , Pessoa de Meia-Idade , Análise de Componente Principal , Saliva/química , Sensibilidade e Especificidade , Microextração em Fase Sólida/métodos , Compostos de Enxofre/classificação , Compostos Orgânicos Voláteis
19.
Biomed Res Int ; 2019: 8043510, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31428646

RESUMO

The aim was to analyze histologically the bone repair in a mandibular osteotomy model with different gaps between the segments. Nine male rabbits who underwent osteotomies on the mandibular body were fixed with a 1.5 system plate and no bone graft; group 1 (2 mm gap between segments), group 2 (5 mm gap between segments), and group 3 (8 mm gap between segments) were included. After 8 weeks they were euthanized and the sample was processed for histological analysis. Group 1 showed advanced bone repair with cartilaginous tissue and cancellous bone, showing osteoblasts and type III collagenous fibers. In group 2, a more delayed ossification was observed, with an extensive area of peripheral ossifying cartilage and chondrocytes in greater number at the center of the defect; group 3 showed no evidence of ossification with fibrous tissue, a very low level of chondrocytes, and some bone sequestrate. We can conclude that, in this animal model, 2 or 5 mm gap in the osteotomy could be repaired as bone when fixation is used. The size of the gap is an important factor for the use of bone grafts considering endochondral ossification. This model can be used for graft analysis and related technologies.


Assuntos
Placas Ósseas , Transplante Ósseo , Mandíbula , Osteotomia Mandibular , Osteoblastos , Osteogênese , Aloenxertos , Animais , Osso Esponjoso/metabolismo , Osso Esponjoso/patologia , Osso Esponjoso/cirurgia , Humanos , Masculino , Mandíbula/metabolismo , Mandíbula/patologia , Mandíbula/cirurgia , Osteoblastos/metabolismo , Osteoblastos/patologia , Coelhos
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