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1.
Curr Opin Ophthalmol ; 31(1): 61-66, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31770163

RESUMO

PURPOSE OF REVIEW: Age-related cataract occurs when crystallin proteins in the lens partially unfold and subsequently aggregate. Physicians and traditional healers alike have been exploring pharmacologic cataract treatment for hundreds of years. Currently, surgery is the only effective treatment. However, there are an abundance of homeopathic and alternative remedies that have been suggested as treatment for cataract. This article reviews the current understanding of cataract development and discusses several homeopathic remedies purported to treat age-related cataract. Additionally, we will present an overview of evidence regarding the development of pharmacologic cataract reversal therapies. RECENT FINDINGS: Some homeopathic therapies have been shown to prevent cataract development in experimental models. More studies are required to elucidate the potential medicinal and toxic properties of the various alternative therapies. However, in recent years, scientists have begun to investigate substances that address cataract by reversing lens protein aggregation. One such compound, lanosterol, was reported to reverse cataract opacity in vitro and in animal models. Subsequently, 25-hydroxycholesterol and rosmarinic acid were identified as having similar properties. SUMMARY: Although challenges and uncertainties remain, further research has the potential to lead to the development of a nonsurgical therapeutic option for age-related cataract.


Assuntos
Catarata/terapia , Materia Medica , Animais , Antioxidantes/uso terapêutico , Cinamatos/uso terapêutico , Depsídeos/uso terapêutico , Humanos , Hidroxicolesteróis/uso terapêutico
2.
Spectrochim Acta A Mol Biomol Spectrosc ; 224: 117463, 2020 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-31421349

RESUMO

Real-time process quality control of ramulus cinnamomi (cassia twig) is still a challenge in pharmaceutical industry. Rapid critical quality attribute (CQA) determination of ramulus cinnamomi is essential for quality control. Microscale thermophoresis (MST) was used to investigate the CQA of ramulus cinnamomi by the interaction with biomacromolecule. There was a good affinity between cinnamaldehyde and human serum albumin (HSA) with Ka as 2.1722×103mol/L. It was an excellent combination of similarity to ibuprofen with same binding force as discovered as hydrogen bond and van der Waals force. Furthermore, regarding cinnamaldehyde as CQA, on-line near-infrared was used to monitor pilot extraction process of ramulus cinnamomi combined with high performance liquid chromatography (HPLC). Quantitative model was established with Rpre2 as 0.9798 and RMSECV as 0.0993, suggesting the NIR model was so robust and accurate for pilot process quality control. This method provided a perfect guideline for rapid CQA determination and real-time process quality control of Chinese materia medica (CMM) based on a vital CQA.


Assuntos
Acroleína/análogos & derivados , Espectroscopia de Luz Próxima ao Infravermelho/métodos , Acroleína/análise , Acroleína/química , Acroleína/metabolismo , Acroleína/normas , Humanos , Lauraceae , Limite de Detecção , Modelos Lineares , Materia Medica/normas , Ligação Proteica , Controle de Qualidade , Reprodutibilidade dos Testes , Albumina Sérica Humana/química , Albumina Sérica Humana/metabolismo , Temperatura Ambiente
3.
Zhongguo Zhong Yao Za Zhi ; 44(18): 4053-4059, 2019 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-31872745

RESUMO

Nanwuweizi( Schisandrae Sphenantherae Fructus) and Wuweizi( Schisandrae Chinensis Fructus) have long-term history of use as common traditional Chinese medicines since the Eastern Han Dynasty( AD.25-220 year).However their information are always confused in ancient literature because they were both used as " Wuweizi". Nanwuweizi and Wuweizi are faced with problems such as confused distribution of producing areas,unclear source plants and efficacy characteristics,which limit modern resource development and application. Based on ancient literatures of materia medica,this study conducted a systematic review from several aspects,i.e. the name,distribution of producing areas,source plants,efficacy characteristics and processing of the two medicines in ancient time. This study clarified five main aspects,as following,ancient production areas and corresponding modern distribution areas; source plants used for medicinal purposes in ancient time; application period and application scope; efficacy characteristics in clinical application;processing method. This study provides a reference for evaluating the quality and for their clinical application and reasonable development of Nanwuweizi and Wuweizi.


Assuntos
Medicamentos de Ervas Chinesas/história , Medicina Herbária/história , Materia Medica , Schisandra , China , História Antiga , Medicina Tradicional Chinesa , Fitoterapia , Plantas Medicinais
4.
Zhongguo Zhong Yao Za Zhi ; 44(21): 4612-4620, 2019 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-31872655

RESUMO

Standard decoction is the core of the pharmacodynamics for water-soluble substance of Chinese materia medica. Its research is of great significance to the research and development of some single ingredients and the classical prescriptions,and it is the only way to transform traditional medication experience into industrial products. In this article,standard decoction research strategies were used for the comparison analysis of Ophiopogonis Radix from Zhejiang province(ZMD),Ophiopogonis Radix from Sichuan province(CMD),and Liriopes Radix(SMD). Regularities were present among different grades of CMD; potential quality markers and pH differences associated with SO2 residues were also found. Finally,the extract powder of Ophiopogonis Radix prepared by mass production process was analyzed and validated,and the results showed that the standard system could be used for the quality control of intermediates and final products. In conclusion,this study can provide reference for the clinical application of Ophiopogonis Radix medicines and provide testing method for higher quality with higher price.


Assuntos
Medicamentos de Ervas Chinesas , Materia Medica , Raízes de Plantas , Controle de Qualidade
5.
Zhongguo Zhong Yao Za Zhi ; 44(21): 4751-4755, 2019 Nov.
Artigo em Chinês | MEDLINE | ID: mdl-31872674

RESUMO

Taking the Zeyao Materia Medica,Benjing Fengyuan,De Pei Materia Medica,Shiyi Materia Medica,Harmful Benefits of Materia Medica as representative works in Qing Dynasty,this paper extracts text information from four aspects: drug identification,drug use,drug prevention and detoxification,constructs a drug pharmacovigilance information table of Qing Dynasty herbal works,and summarizes the drug pharmacovigilance of Qing Dynasty. Thought,in the Qing Dynasty,there were many recordings of drug pharmacovigilance. In the aspect of drug awareness,the main representative was Shi Yi Materia Medica which added many new drugs and introduced more new uses of drugs. In addition,in the aspect of drug use and prevention,the main representatives were Zeyao Materia Medica,Benjing Fengyuan,De Pei Materia Medica,and Harmful Benefits of Materia Medica. In the aspect of taboo of disease and syndrome,attention should be paid to the integration of medicine so as to make drugs closely related to clinical use. Although there is no special introduction on detoxification,it has been introduced in various medicines in the De Pei Materia Medica,Shiyi Materia Medica,which has a relatively systematic and complete drug warning ideology system of " drug identification-use-drug prevention-detoxification".This study found that the traditional pharmacovigilance thought of Qing Dynasty had the characteristics of attaching importance to the clinical application of toxic traditional Chinese medicine and the combination of medicine,which had certain guiding significance for modern clinical medication. This paper aims to explore the traditional drug pharmacovigilance knowledge in representative works of the Qing Dynasty,analyze the characteristics of the drug pharmacovigilance thought in the Qing Dynasty,and lay a foundation for clarifying the traditional drug pharmacovigilance system.


Assuntos
Medicamentos de Ervas Chinesas , Materia Medica , Medicina Tradicional Chinesa , China , Sistemas de Liberação de Medicamentos , Farmacovigilância , Registros
6.
Adv Exp Med Biol ; 1181: 1-13, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31677138

RESUMO

Shen Nong Ben Cao Jing (Shennong Materia Medica) and many other books in early Chinese history began to study, discuss, and report the scientific aspects of Ganoderma (Lingzhi) in respect to its categorization, habitat, bionomics, herbal nature, medication, etc. At the same time, incorrect or unsubstantiated information continues to be weeded out and updated. Shennong Materia Medica have been frequently referred in literature and used for further research and applications. Present chapter reviews the history of modern research on Ganoderma (Lingzhi) since 1950s.Historically, Lingzhi has been viewed as a magic herb as well as an auspicious symbol by the Chinese. It is, therefore, also known as "Ruizhi," "Shenzhi," and "Xiancao," with the meaning of good fortune and mysterious power. Taoism played an important role in promoting Lingzhi for either medical purposes or otherwise. Numerous myths and poems mentioning people's love, worshipping, and beliefs on Lingzhi can be found in the Chinese literature since ancient times.


Assuntos
Cultura , Medicamentos de Ervas Chinesas , Ganoderma , Materia Medica , Medicina Tradicional Chinesa , Humanos , Reishi
7.
Zhongguo Zhong Yao Za Zhi ; 44(14): 2972-2979, 2019 Jul.
Artigo em Chinês | MEDLINE | ID: mdl-31602842

RESUMO

The Silk Road and the Maritime Silk Road were the important accesses for the exchanges of herbal medicine between the primary traditional medical systems in the ancient world,which also are the strategic links between the areas with herbal medicine widely used and the most active markets for herbs at present. This article focuses on the foreign medicinal resources introduced to traditional Chinese medicine( TCM) in China. As new resources of Chinese Materia Medica( CMM),the four basic conditions should be required,which are the clear origin,the safety and effectiveness in clinical,the efficacy and properties described with theory of TCM.Medicinal property is the key scientific problem of foreign medicinal resources introduced to TCM. The research strategies include three aspects. Medicinal properties of foreign medicinal resources will be deduced and analyzed across multiple medical systems by solving the difference depending on finding the similarities of traditional medical systems. The medicinal properties-efficacies of foreign medicinal resources will be identified by identifying Xiang and selecting similar CMM. And Xiang-properties-efficacies of foreign medicinal resources will be researched under formulae environment using medicinal properties.


Assuntos
Materia Medica , Medicina Tradicional Chinesa , China , Medicina Herbária
8.
Zhongguo Zhong Yao Za Zhi ; 44(17): 3637-3644, 2019 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-31602935

RESUMO

The biopharmaceutics classification system( BCS) is a scientific framework or method for classifying drugs based on drug solubility and permeability,which can be used to provide drug bioavailability-absorption correlation analysis. Based on the characteristics of multi-component and multi-target of traditional Chinese medicine( TCM) as well as the concept,method and technology of BCS,the research group proposed biopharmaceutics classification system of Chinese materia medica( CMMBCS) and carried out research and data accumulation of classical prescriptions. Based on the previous research results,further development ideas under the CMMBCS concept and framework were further proposed in this study. In the course of research,the influence of the intermediate links of the complex interactions of the multi-component environment was omitted,and the component absorption studies on the main clinical effects of prescription ingredients were directly concerned,or the components and data were reversely extracted from the aspects of metabolism,pharmacodynamic pathways and absorption principles. Studies were conducted from two aspects( single component and compound prescription) to comprehensively evaluate the absorption properties of TCM compound. In the research path,the different ways in which Chinese medicine could exert its efficacy were fully considered,and CMMBCS classification and establishment rules were clarified mainly by focusing on the absorption pathway into the blood. Specifically,the network pharmacology and molecular docking technology were used to screen the compound index components of TCM; the absorption rules were studied by the physiologically based pharmacokinetic models and the absorption parameters of CMMBCS were calculated by reverse reasoning. Then the CMMBCS classification of TCM prescription was corrected by studying the efficacy or absorption pathway. In this paper,the theoretical framework and research methodology of CMMBCS were systematically improved based on the establishment of CMMBCS basic theory,the supplementary of drug-oriented research ideas and the application of modern mature Chinese medicine methodology.


Assuntos
Biofarmácia/classificação , Medicamentos de Ervas Chinesas/classificação , Materia Medica/classificação , Simulação de Acoplamento Molecular
9.
Zhongguo Zhong Yao Za Zhi ; 44(17): 3653-3661, 2019 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-31602937

RESUMO

For the effects of multi-component environment on the solubility and permeability of single components,and the problems of biopharmaceutical attribute classification of single components in the compound prescriptions environment,baicalein was used as the research object in this study to investigate the biopharmaceutic attributes of single-component and their traditional Chinese medicine( TCM) biopharmaceutic attributes in the multi-component environment of Gegen Qilian Decoction. Shaking flask method,intrinsic dissolution rate test and HPLC were used to determine solubility of baicalein. Markers specified by FDA were utilized as permeable boundary reference materials to verify the applicability of the single-pass intestinal perfusion method( SPIP),and the quantitative research on the permeability of baicalein was also conducted. It is concluded that baicalein could be categorized as BCS-Ⅱ drug based on its low solubility and high intestinal permeability values,and it may be categorized into CMMBCS-I in the multi-component environment of Gegen Qilian Decoction due to its poor solubility but enhanced solubility and permeability in compound environment. This study could provide verification ideas for clinical determination of the best human oral dose of baicalein,and provide the data basis for the study of biopharmaceutics classification system of Chinese materia medica( CMMBCS).


Assuntos
Biofarmácia/classificação , Medicamentos de Ervas Chinesas/química , Flavanonas/química , Materia Medica/classificação , Humanos , Absorção Intestinal , Permeabilidade , Solubilidade
10.
Zhongguo Zhong Yao Za Zhi ; 44(17): 3662-3671, 2019 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-31602938

RESUMO

The research on biopharmaceutics classification system of Chinese materia medica( CMMBCS) should be finally implemented to the holistic research level of traditional Chinese medicine compounds,while the overall biopharmaceutical properties of traditional Chinese medicine compounds are not only the sum of solubility and permeability of each component. In this study,Gegen Qinlian Tablets was used as the research object,and the contents of 12 representative components,i.e. puerarin,daidzin,baicalin,daidzein,wogonoside,baicalein,wogonin,glycyrrhizic acid,coptisine hydrochloride,epiberberine,berberine hydrochloride and palmatine hydrochloride,were simultaneously determined by HPLC to obtain the mass weight of each component. The in vitro lipopolysaccharide( LPS)-induced RAW264. 7 cells inflammation model was established to investigate the anti-inflammatory effects of 12 representative components and obtain the efficacy weight of each component. In order to obtain the number of doses and effective permeability coefficient which can represent the overall biopharmaceutical properties of Gegen Qinlian Tablets,mass weight was combined with efficacy weight to integrate the solubility and permeability data of each component determined by typical shake flask method and in situ single pass intestinal perfusion model respectively. The results indicated that Gegen Qinlian Tablets should be categorized Ⅳ drug of the CMMBCS with low solubility and low permeability.


Assuntos
Anti-Inflamatórios/farmacologia , Biofarmácia/classificação , Medicamentos de Ervas Chinesas/classificação , Materia Medica/classificação , Medicamentos de Ervas Chinesas/farmacologia , Comprimidos
11.
Zhonghua Yi Shi Za Zhi ; 49(4): 195-198, 2019 Jul 28.
Artigo em Chinês | MEDLINE | ID: mdl-31495157

RESUMO

Ointment in traditional Chinese medicine appeared very early, as early as in the Shan Hai Jing(, The Classic of Mountains and Seas) has been recorded, Wushier Bing Fang(, Prescriptions for Fifty-two Diseases), unearthed in the Mawangdui Han Tomb, there were many cases of ointment in it.The earliest paste named after "plaster" with complete formulation and application method can be found in Wuwei Han Dynasty Medical Slips.In the Northern and Southern Dynasties, Tao Hongjing's Shennong Bencao Jing Jizhu(, Collected Commentaries to the Materia Medica) presented a detailed description of the production process of ointment.The production and use of ointment in Sui and Tang Dynasties were more standardized. And ointment was widely used in Tang Dynasty. The term "yougao" (, grease) appeared in the book Beiji Qianjin Yaofang(, Essential Recipes for Emergent Use Worth A Thousand Gold), and "yaogao" (, unguent) was used earlier in the book Ishimpo(), which was used to refer to ointment.The word "ruangao" (, unguentum) was used earlier in the Yuji Weiyi(), a book from Ming Dynasty, and its connotation is basically the same as that of modern ointment.The term "rugao" (, cream) appeared again in Puji Fang(, Prescriptions for Universal Relief), referring to the ointment having a milk base.The term "ointment" was first recorded in Liangyao Yu Duyao (, Good medicine and Poisons), which published in 1932. Since then, the name "ointment" has been used in all traditional Chinese medical works.


Assuntos
Materia Medica , Medicina Tradicional Chinesa , Pomadas , Livros , China , Pesquisa
12.
Zhonghua Yi Shi Za Zhi ; 49(4): 239-244, 2019 Jul 28.
Artigo em Chinês | MEDLINE | ID: mdl-31495165

RESUMO

Published in the Ming Dynasty around 1593 to 1596, the Jinling Edition of the Compendium of Materia Medica is considered the earliest engraved version. This edition has considerable literary and academic value. Only a handful of copies remain as they had to survive more than 400 years of human conflict and environmental damage such as mold and mildew. Throughout history, many ancient books, including herbal materia medica, have been exported to overseas, following the expansion of trade and cultural exchange. In Japan, many of these books are still well preserved. The author conducted a field investigation to Tohoku University in Sendai, Tokyo's Oriental Library, the Cabinet Library of the National Archives, and the National Diet Library to study four very well-preserved Jinling Editions of the Compendium of Materia Medica to fully understand the development of traditional medicine in Japan.


Assuntos
Bibliotecas , Materia Medica , Livros , Humanos , Japão , Medicina Tradicional
13.
Biomed Pharmacother ; 118: 109372, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31545236

RESUMO

Apoptosis is an evolutionarily conserved suicide process. It plays critical roles in the development and homeostasis of cardiac tissues. However, excessively stimulated apoptotic activity induced by a myriad of deleterious stimuli can result in too much cardiomyocyte death. The regenerative potential of the adult cardiomyocytes is limited. The cardiomyocyte loss cannot be compensated by efficient cell proliferation. It inevitably leads to various heart diseases. Therefore, the inhibition of cardiomyocyte apoptosis is an important therapeutic strategy for heart diseases. Chinese materia medica (CMM) has more than 2000 years of history and provides effective adjuvant therapeutic strategies for heart disease at the clinical level. The mechanisms underlying the beneficial effects of CMM on heart diseases have been a major focus of recent research. Interestingly, it has been demonstrated that CMM can up-regulate the levels of anti-apoptotic proteins and down-regulate the levels of pro-apoptotic proteins to inhibit apoptotic activity, thereby suppressing cardiomyocyte apoptosis in response to harmful stimuli. The inhibitory effects of CMM on apoptotic activity are mediated by the transduction of intracellular signaling. In this review, we summarize and discuss current findings on the roles and mechanisms of CMM in cardiomyocyte apoptosis.


Assuntos
Apoptose/efeitos dos fármacos , Materia Medica/farmacologia , Miócitos Cardíacos/patologia , Animais , Humanos , Medicina Tradicional Chinesa , Miócitos Cardíacos/efeitos dos fármacos , Transdução de Sinais/efeitos dos fármacos , Estresse Fisiológico/efeitos dos fármacos
14.
Medicine (Baltimore) ; 98(35): e16895, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31464920

RESUMO

RATIONALE: Methotrexate (MTX) is an antimetabolite of folic acid, which is used for management of ectopic pregnancy. MTX-related toxicity may include cutaneous mucosal damage, bone marrow suppression, gastrointestinal disorders (gastritis, diarrhea, hematitis), liver and kidney function damage, pulmonary toxicity, cardiac toxicity, and nerve toxicity. However, it is not usual for vulvar edema induced by low-dose methotrexate. PATIENT CONCERNS: In this case report, we described a patient with severe vulvar edema and oral cavity ulceration and scalp ulceration induced by low-dose MTX treatment for ectopic pregnancy. Her presenting complaints were pain in the vulva, oral cavity, and scalp. DIAGNOSES: The patient was diagnosed based on clinical findings for MTX toxic reactions. INTERVENTIONS: Vulva was disinfectioned with iodide and Kangfuxin solution, her mouth was rinsed with mouthwash. Three compound glycyrrhizin tablets were orally administered (3 times/day). After 10 days, the broken skin and mucous membrane healed. OUTCOMES: The vulvar edema and oral cavity ulceration and scalp ulceration healed. LESSONS: Our study demonstrated that even low-dose MTX can be induced skin and mucosal injury, patients and doctors should timely detection of drug toxicity reactions, immediately rescue, prompt discontinuation of medication, and symptomatic treatment to avoid accidental occurrence.


Assuntos
Metotrexato/administração & dosagem , Metronidazol/administração & dosagem , Gravidez Ectópica/tratamento farmacológico , Vaginite por Trichomonas/tratamento farmacológico , Doenças da Vulva/induzido quimicamente , Dor Abdominal/etiologia , Administração Oral , Adulto , China , Feminino , Ácido Glicirrízico/administração & dosagem , Ácido Glicirrízico/uso terapêutico , Humanos , Injeções Intramusculares , Materia Medica/administração & dosagem , Materia Medica/uso terapêutico , Metotrexato/efeitos adversos , Metronidazol/uso terapêutico , Gravidez , Gravidez Ectópica/diagnóstico , Resultado do Tratamento , Hemorragia Uterina/etiologia , Doenças da Vulva/tratamento farmacológico
15.
J Altern Complement Med ; 25(9): 890-901, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31290681

RESUMO

Objectives: In Part 1 of the review of physicochemical research performed on homeopathic preparations the authors identified relevant publications of sufficient reporting quality for further in-depth analysis. In this article, the authors analyze these publications to identify any empirical evidence for specific physicochemical properties of homeopathic preparations and to identify most promising experimental techniques for future studies. Methods: After an update of the literature search up to 2018, the authors analyzed all publications in terms of individual experiments. They extracted information regarding methodological criteria such as blinding, randomization, statistics, controls, sample preparation, and replications, as well as regarding experimental design and measurement methods applied. Scores were developed to identify experimental techniques with most reliable outcomes. Results: The publications analyzed described 203 experiments. Less than 25% used blinding and/or randomization, and about one third used adequate controls to identify specific effects of homeopathic preparations. The most promising techniques used so far are nuclear magnetic resonance (NMR) relaxation, optical spectroscopy, and electrical impedance measurements. In these three areas, several sets of replicated high-quality experiments provide evidence for specific physicochemical properties of homeopathic preparations. Conclusions: The authors uncovered a number of promising experimental techniques that warrant replication to assess the reported physicochemical properties of homeopathic preparations compared with controls. They further discuss a range of experimental aspects that highlight the many factors that need to be taken into consideration when performing basic research into homeopathic potentization. For future experiments, the authors generally recommend using succussed (vigorously shaken) controls, or comparing different homeopathic preparations with each other to reliably identify any specific physicochemical properties.


Assuntos
Materia Medica , Bibliometria , Homeopatia , Materia Medica/análise , Materia Medica/química , Materia Medica/classificação
16.
Oxid Med Cell Longev ; 2019: 4739450, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31281578

RESUMO

Oviductus ranae is an animal-based traditional Chinese material widely used as tonics in China for hundreds of years. Various bioactive components are present in OR including proteins, amino acids, steroids, fatty acids, phospholipids, nucleosides, vitamins, hydantoins, and mineral elements. These constituents exert a myriad of biological functions such as immunomodulatory, antioxidant, antifatigue, antiaging, estrogen-like, hepatoprotective, hypolipidemic, antiosteoporotic, antidepressant, antitumor, antitussive, expectorant, anti-inflammatory, and antiasthmatic activities. Unlike other traditional Chinese crude drugs recorded in Chinese Pharmacopoeia, OR is seldom prescribed as medicine but often consumed as nutraceuticals to optimize health. In this review, the traditional uses, bioactive constituents, biological functions, and safety properties of OR as functional foods in China were summarized and discussed. It is expected that this review will provide useful information for anyone who is interested in OR.


Assuntos
Alimento Funcional , Materia Medica , Medicina Tradicional Chinesa/métodos , China , Humanos
17.
Zhonghua Yi Shi Za Zhi ; 49(3): 131-134, 2019 May 28.
Artigo em Chinês | MEDLINE | ID: mdl-31269620

RESUMO

The Compendium of Materia Medica is a magnum opus, in which a large number of literatures were cited. By searching with keywords, there were 30 citations related with Hua Tuo in this book. However, some citations were not specific, even lack of the source information. The objective of this article is to find out the contents, first-hand source and editions of the primary literatures by doing textual research.As a result, the sources of quotations about the Hua Tuo's Prescription for Madam Pengcheng and Hua Tuo's Emergency Cases Prescriptions were discovered.Meanwhile, it was confirmed that Zhongzang Jing (, Classic of the Central Viscera) with 3 volumes and books of prescriptions during Song and Ming Dynasties were cited by the Compendium of Materia Medica. This solve the long term problem about Hua Tuo's citations, and might benefit further study about the citations of the Compendium of Materia Medica.


Assuntos
Materia Medica , Livros , China , Pesquisa
18.
Zhonghua Yi Shi Za Zhi ; 49(3): 146-162, 2019 May 28.
Artigo em Chinês | MEDLINE | ID: mdl-31269623

RESUMO

The Jinling version of the Compendium of Materia Medica was the primary version.It accurately represented the ideas of LI Shizhen, therefore it was valued by the scholars.There were many defects in misprint (knife carving) and proofreading.The main errors were some Chinese character's strokes missing and wrong characters printed.The authors collected some statistics data andmade some statistical analysis. They found that total misprints were 376 and emerge 615 times.Those misprints can divide into two categories: lack of some parts of Chinese characters; lack of some strokes of Chinese characters.Four tables which list the misprints was made.It is helpful for scholars to examine Compendium of Materia Medica or the study of other similar ancient literatures.


Assuntos
Medicamentos de Ervas Chinesas , Materia Medica
19.
Zhonghua Yi Shi Za Zhi ; 49(3): 179-182, 2019 May 28.
Artigo em Chinês | MEDLINE | ID: mdl-31269626

RESUMO

More than 410 kinds of prescriptions of medicines were presented, some of which were collected in Shennong Bencao Jing(, Shennong's Classic of Materia Medica) and other herbal works, are included in Lu Zhiyi's Bencao Chengya Banji(). He introduced the indications of these medicines by focusing on the name of the herbs, or the species of them, and the features and growth morphology of the herbs. He abstracted the efficacy of drugs on the human body. Therefore, he noted the indications of all the medicines list in the book.


Assuntos
Medicamentos de Ervas Chinesas , Materia Medica , Livros , Humanos
20.
Artigo em Chinês | MEDLINE | ID: mdl-31327203

RESUMO

Objective:TThe aim of this study is to investigate the effect of in vitro cultured Calculus Bovis on the inflammation of oropharynx and body in patients with OSA during the perioperative period of H-UPPP.Method:Eighty patients with OSA and H-UPPP indications were enrolled. The patients were divided into experimental group and control group by random number table, 40 cases in each group. The experimental group was given in vitro cultured Calculus Bovis, while the control group was not given bovine bezoar in vitro. The postoperative oropharyngeal pain, time to resume normal diet, local edema, concentration of IL-1ß, IL-8 and TNF-α in saliva, and concentration of IL-1ß, IL-8 and TNF-α in blood were compared between the two groups. Result:The pain of oropharynx in the experimental group was lighter than that in the control group on the 3rd, 5th and 7th day after operation (P<0.05), but there was no significant difference in the pain of oropharynx between the two groups on the 1st day after operation(P>0.05); the time of restoring normal diet in the experimental group was shorter than that in the control group (P<0.05); the edema of oropharynx in the experimental group was lighter than that in the control group on the 5th and 7th day after operation (P<0.05).The levels of IL-1ß, IL-8 and TNF-α in saliva were lower than those in control group on the 3rd, 5th and 7th day after operation (P<0.05), and the levels of IL-1ß, IL-8 and TNF-α in blood on the 5th and 7th day after operation were lower than those in control group (P<0.05).Conclusion:In vitro perioperative period of H-UPPP can improve the postoperative sore throat and local edema of oropharynx, shorten the time of normal diet and reduce the expression of related inflammatory factors in oropharynx and blood.


Assuntos
Ácidos Cólicos/uso terapêutico , Inflamação/prevenção & controle , Materia Medica/uso terapêutico , Orofaringe/patologia , Procedimentos Cirúrgicos Otorrinolaringológicos , Apneia Obstrutiva do Sono/cirurgia , Animais , Bovinos , Humanos , Interleucina-1beta/análise , Interleucina-8/análise , Período Pós-Operatório , Fator de Necrose Tumoral alfa/análise
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