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1.
Medicine (Baltimore) ; 99(5): e18968, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32000424

RESUMO

BACKGROUND: Lung cancer is one of the most common cancers worldwide, and approximately half of the patients with lung cancer receiving chemotherapy suffer from cancer-related fatigue (CRF). Herbal medicines (HMs) have been used in Oriental countries for centuries as tonics. Various beneficial effects of HM on fatigue and cancer have been reported. However, the effectiveness and safety of HM for CRF in lung cancer patients have not been synthesized. The purpose of this systematic review is to evaluate the effectiveness and safety of HM for CRF in patients with lung cancer, regardless of their cancer type or stage. METHODS AND ANALYSIS: A comprehensive search will be conducted in 12 electronic medical databases including 5 English-language databases (Medline via PubMed, EMBASE via Elsevier, the Cochrane Central Register of Controlled Trials [CENTRAL], the Allied and Complementary Medicine Database [AMED] via EBSCO, and the Cumulative Index to Nursing and Allied Health Literature [CINAHL] via EBSCO), 4 Korean-language databases (Oriental Medicine Advanced Searching Integrated System [OASIS], Koreanstudies Information Service System [KISS], Research Information Service System [RISS], and Korea Citation Index [KCI]), 2 Chinese-language databases (China National Knowledge Infrastructure [CNKI] and Wanfang Data), and 1 Japanese-language database (CiNii). Only randomized controlled trials (RCTs) and quasi-RCTs on HM for CRF will be allowed. The severity of fatigue assessed using a validated tool will be considered as theprimary outcome. The secondary outcomes will include the patients' quality of life, activities of daily life, incidence of adverse events, and total effective rate. Two independent researchers will perform the study selection, data extraction, and quality assessment. RevMan version 5.3 will be used for data synthesis. The methodological quality of the included RCTs will be assessed using the Cochrane Collaboration's risk of bias tool. In the meta-analysis, for dichotomous data and continuous data, risk ratio and mean difference, respectively, will be estimated with their 95% confidence intervals. According to the heterogeneity, either a fixed-effects or a random-effects model will be used. ETHICS AND DISSEMINATION: Ethical approval is not required because individual patient data are not included. The findings of this systematic review will be disseminated through a peer-reviewed publication or conference presentation. PROSPERO REGISTRATION NUMBER: CRD42019141660.


Assuntos
Sobreviventes de Câncer , Medicamentos de Ervas Chinesas/uso terapêutico , Fadiga/tratamento farmacológico , Fadiga/etiologia , Medicina Herbária/métodos , Neoplasias Pulmonares/complicações , Medicina Tradicional do Leste Asiático/métodos , Revisão Sistemática como Assunto , Humanos , Projetos de Pesquisa
2.
Medicine (Baltimore) ; 98(29): e16368, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31335684

RESUMO

BACKGROUND: Acupoint herbal patching (AHP) is widely used for symptom management in patients with acute and chronic bronchitis. The purpose of this protocol review is to evaluate the safety and efficacy of AHP for the treatment of bronchitis. METHODS AND ANALYSIS: This protocol of systematic review will be conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P). The databases searched will include PubMed, Embase, CENTRAL, Web of Science, 3 Korean medical databases (OASIS, Korea Med, and KMBASE), and the Chinese database China National Knowledge Infrastructure (CNKI). Randomized controlled trials (RCTs) or quasi-RCTs using AHP for bronchitis will be considered. The selection of the studies, data abstraction, and validations will be performed independently by 3 researchers. CONCLUSION: The conclusion of the review will provide evidence that AHP is an effective intervention in patients with bronchitis. ETHICS AND DISSEMINATION: As individuals were not involved, ethical approval is not required. Findings will be published in a peer-reviewed journal. This systematic review may inform the treatment of bronchitis patients in clinical practice. REGISTRATION: This systematic review has been registered with the International Prospective Register of Systematic Reviews (PROSPERO). The reference number is CRD42018110380.


Assuntos
Pontos de Acupuntura , Bronquite/terapia , Terapias Complementares/métodos , Medicina Herbária/métodos , Administração Cutânea , Protocolos Clínicos , Humanos , Medicina Tradicional do Leste Asiático , Resultado do Tratamento
3.
Phytother Res ; 33(9): 2409-2420, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31313391

RESUMO

Herbal medicines are not only widely used but also contentious health care products. Currently, little is known about the products' place in people's health care strategies and their views about such products. The aims of the study are to gain insight into the public's perception of herbal medicine/general use of herbs for health, as well as on the growing of plants for medicine. Core to the research was a survey that covered participants' views about herbal medicines. Data were collected online and from visitors at the Eden Project, as well as some other garden events. Survey responses were categorized and analysed using Qualtrics. Overall, 408 participants participated though numbers varied across questions. Results show that herbal medicines are popular, particularly amongst the 36- to 55-year-old age group. Participants mostly used herbal medicines for minor self-limiting conditions. Popular reasons for use included that plant medicines are natural and have fewer side effects, as well as for a few changing relationship with conventional medicines. Around a third of participants grew their own plants for health care. This is the first larger U.K.-based survey indicating a wide use of such products, and it is therefore recommended that there is an increase in quality control and wider regulation. Access to high-quality products should be prioritized.


Assuntos
Medicina Herbária/métodos , Plantas Medicinais/química , Adulto , Feminino , Humanos , Estilo de Vida , Masculino , Pessoa de Meia-Idade , Reino Unido
4.
Phytother Res ; 33(9): 2360-2368, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31282109

RESUMO

Health care professionals (HCPs) have a pivotal role in optimizing patient care and should be familiar with complementary and alternative medicines. The aim of the study was to explore UK-based HCP personal and professional opinions and experiences of herbal medicines (HMs). An online questionnaire was distributed via social media to recruit (n = 112) a range of HCPs from across the United Kingdom. HCPs from primary and secondary care, the private sector, and academia took part. A large proportion of participants (62%) said they did not personally use any HMs, and 38% did use HMs. HCPs who had personally used HMs had a positive impression of HMs and were more likely to recommend HMs to patients than those who had not used HMs themselves. Participants were given the opportunity to share their perceptions on the safety and efficacy of HMs and their experiences with patients reporting adverse drug reactions to HMs and herb-drug interactions. HCPs identified their lack of knowledge on HMs and insufficient training, which made them unable to advise patients on the safe use of HMs. More education on HMs would help improve HCP knowledge of HMs and help them make better informed decisions when considering patient pharmaceutical care plans.


Assuntos
Pessoal de Saúde/normas , Interações Ervas-Drogas , Medicina Herbária/métodos , Feminino , Humanos , Masculino , Reino Unido
5.
Planta Med ; 85(13): 1044-1053, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31261419

RESUMO

This prospective, noninterventional, multicenter 12-wk study in women with overactive bladder investigated the effectiveness of Granu Fink femina, a herbal combination of seed oil from Uromedic pumpkin (cultivar of Cucurbita pepo), Rhus aromatica (fragrant sumach) bark extract, and Humulus lupulus (hop) cone extract in a clinical setting. Patients documented overactive bladder symptoms and quality of life using questionnaires as well as diaries recording day- and nighttime micturition frequencies, urine leakages during physical activity or at sneezing or coughing, and use of incontinence pads. The full analysis set included 117 women (age: 21 - 78 y). Urination frequency decreased significantly with improvement during daytime in 49, 71, and 77 (out of 99) patients and at night in 45, 63, and 70 (out of 100) patients after 1, 6, and 12 wk, respectively. The mean frequency of leakages and used pads decreased significantly from 0.9 leakages and 2.0 pads at baseline to 0.4 leakages and 1.4 pads after 12 wk. In all measured aspects of overactive bladder-related quality of life, (coping, concern, sleep, social), statistically significant improvement was reached after 1 wk, with further improvement at 6 and 12 wk. Ninety-nine percent of the physicians and 95.4% of the patients rated tolerability as "very good" or "good". Treatment with Granu Fink femina progressively improved overactive bladder symptoms and related quality of life with significant improvements already after 1 wk. Based on these effects and the observed excellent tolerability profile, Granu Fink femina may be considered a valuable therapeutic option for overactive bladder.


Assuntos
Cucurbita , Humulus , Fitoterapia/métodos , Preparações de Plantas/uso terapêutico , Rhus , Bexiga Urinária Hiperativa/tratamento farmacológico , Adulto , Idoso , Feminino , Medicina Herbária/métodos , Humanos , Pessoa de Meia-Idade , Preparações de Plantas/administração & dosagem , Adulto Jovem
6.
Complement Ther Med ; 44: 1-8, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31126540

RESUMO

OBJECTIVES: A systematic review was conducted to assess the effect of vitamin E on the severity and duration of Cyclic Mastalgia compared to vitamin B6, fish oil, herbal medicines and placebo. DESIGN: A systematic review and meta-analysis of clinical trials. METHODS: A search was carried out in PubMed, Cochrane Library, Embase, Scopus and Google Scholar and Persian databases for articles published from 1980 to 2018. The data obtained were analyzed in RevMan and reported in forest plots. The Odds Ratio (OR) was used to find the effect for the dichotomous data and the Standardized Mean Difference (SMD) for the continuous data. The heterogeneity of the studies was assessed using I2 and the Random Effects Model was used instead of the Fixed Effects Model if I2>25%. RESULTS: A total of 1051 titles and abstracts were extracted. Fourteen articles ultimately remained, and 11 of them were entered into the meta-analysis. The meta-analysis showed significant differences between vitamin E and placebo in the severity (SMD=-0.51; 95% CI=-0.21 to -0.82) and duration (MD=-1.47; 95% CI=-0.91 to -2.57) of cyclic mastalgia, although herbal medicines had a greater effect on the severity of mastalgia than vitamin E (SMD = 0.51, 95% CI = 0.06 to 0.96). CONCLUSION: Although herbal medicines are more effective than vitamin E, vitamin E reduces both the severity and duration of the disorder compared to placebos, which only reduce its severity, and can therefore be considered a treatment with minimum side-effects. Due to the high heterogeneity of the studies, the researchers recommend further research on the subject using a standard tool based on the CONSORT statement.


Assuntos
Mastodinia/tratamento farmacológico , Vitamina E/administração & dosagem , Animais , Medicina Herbária/métodos , Humanos , Índice de Gravidade de Doença
7.
Complement Ther Med ; 44: 242-252, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31126562

RESUMO

The suppression of appetite with herbal medicines has become very popular in recent years. We conducted this systematic review to evaluate the recent scientific evidence regarding herbal medicines that are used to suppress appetite. We retrieved clinical trials from PubMed, Cochrane Central Register of Controlled Trials, Web of Science, Scientific Information Database, and IranMedex from January 1, 2013 to April 24, 2018. English and Persian language randomized clinical trials that used herbal medicines to suppress appetite in healthy or obese or overweight individuals were included. Risk of bias was assessed using Cochrane methodology. Out of 591 articles, 22 trials with 973 participants were included. One study on the Meratrim formulation which contained the Sphaeranthus indicus flower heads extract and Garcinia mangostana fruit, revealed longer-term evidence; while 6 studies on Ilex paraguariensis, Spinacia oleracea, Phaseolus vulgaris, Secale cereale, Sorghum bicolor and Plantago showed short-term evidence for suppressing appetite. No serious adverse events were reported. Despite some methodological concerns in the included studies, there is promising evidence for suppressing appetite with herbal medicines that needs to be confirmed in long-term clinical trials with adequate sample size and higher methodological quality with more attention to safety, effective dose and side effects.


Assuntos
Apetite/efeitos dos fármacos , Medicamentos de Ervas Chinesas/uso terapêutico , Medicina Herbária/métodos , Humanos , Fitoterapia/métodos , Plantas Medicinais , Ensaios Clínicos Controlados Aleatórios como Assunto
8.
Complement Ther Clin Pract ; 35: 368-373, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31003684

RESUMO

BACKGROUND: and Purpose: Using of herbal medicines is common for cancer treatment. The aim of this study was to determine the prevalence, reasons, and predicting factors for the use of herbal medicines by Iranian cancer patients. MATERIALS AND METHODS: We conducted this cross-sectional study on 315 cancer patients through face-to-face interview in Kerman, Southeast of Iran, 2017. RESULTS: In total, 267 (84.1%) patients used at least one herbal medicine during chemotherapy courses, while only 42 (16.1%) patients discussed the use of herbal medicines with physicians. Living in urban regions (OR, 2.56; 95% CI, 1.30-5.05; P<0.0001) and the experience of constipation and diarrhea (OR, 2.11; 95% CI, 1.09-4.05; P = 0.02) were determined as some predicting factors for the use of herbal medicines. CONCLUSION: Our findings indicate that as herbal medicines are common among cancer patients and their use is often overlooked, physicians should pay particular attention to herbal medicines during chemotherapy.


Assuntos
Medicina Herbária/métodos , Medicina Herbária/estatística & dados numéricos , Neoplasias/tratamento farmacológico , Fitoterapia/métodos , Fitoterapia/estatística & dados numéricos , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos Transversais , Feminino , Humanos , Irã (Geográfico) , Masculino , Pessoa de Meia-Idade , Prevalência
9.
Medicine (Baltimore) ; 98(8): e14543, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30813162

RESUMO

BACKGROUND: Herbal medicines have the potential to be alternative treatments for metabolic diseases. This systematic review will assess the efficacy of herbal medicines in treating metabolic diseases with blood stasis. METHODS AND ANALYSIS: We will search MEDLINE, the Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, 2 Korean medical databases (OASIS, NDSL), a Chinese database (China National Knowledge Infrastructure, CNKI), and a Japanese database (J-STAGE) for relevant literature. We will include all randomized controlled trials (RCTs) or quasi-RCTs evaluating the effectiveness of herbal medicine. Participants of both sexes and of any age with clinically diagnosed metabolic disease with blood stasis will be included. Primary outcomes will include Blood-stasis syndrome score, TC, TG, HDL-C and LDL-C. Secondary outcomes will Blood pressure, FBS. ECG, prevalence rate of heart disease, and response rate. The risk of bias will be assessed using the Cochrane tool for assessing risk of bias. DISCUSSION: The findings of this study will provide a summary of the current state of evidence regarding the effectiveness of types of herbal medicine in managing metabolic disease with blood stasis. In addition, this review will be expected to provide a base for clinical trials to confirm the efficacy of herbal medicine for treatments of metabolic disease with blood stasis. TRIAL REGISTRATION NUMBER: PROSPERO 2018 CRD42018090179.


Assuntos
Transtornos da Coagulação Sanguínea/terapia , Medicina Herbária/métodos , Doenças Metabólicas/terapia , Fitoterapia/métodos , Transtornos da Coagulação Sanguínea/complicações , Feminino , Humanos , Masculino , Doenças Metabólicas/complicações , Plantas Medicinais/efeitos dos fármacos , Projetos de Pesquisa , Resultado do Tratamento
10.
Mol Biol Rep ; 46(3): 2961-2969, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30887260

RESUMO

In the present study, Amukkara Chooram (AC) a well known herbal medicine was investigated for their antibiofilm efficacy against biofilm of Candida albicans. The biofilm inhibitory concentration of 20 µg/mL of AC showed promising effect by inhibiting the biofilm upto 60%. Morphogenic transition state of C. albicans from yeast cells to hyphal transition was prevented by AC was revealed from light microscopic images. In addition, the inhibition of yeast hyphae was examined in the induction medium supplemented with AC. Consequently, atomic force microscope (AFM) also documented the morphological changes observed during the transition state of C. albicans in the presence and absence of AC. Furthermore, scanning electron microscope (SEM) and confocal laser scanning microscopic (CLSM) images showed reduction in the biomass and thickness of the mature biofilm of C. albicans. In vivo investigation of C. albicans with zebrafish infection model presented the clearance of biofilm from the epithelium of the intestinal tissues. Later, the histological changes in liver and kidney due to C. albicans infection open up that treatment with AC was able to significantly rejuvenate the tissues. Altogether, the study presents AC as potent antibiofilm agent with potential ability as alternative medicine to treat C. albicans biofilm mediated infections.


Assuntos
Candida albicans/efeitos dos fármacos , Extratos Vegetais/farmacologia , Withania/química , Animais , Biofilmes/efeitos dos fármacos , Medicina Herbária/métodos , Virulência , Withania/metabolismo , Withania/fisiologia , Peixe-Zebra/microbiologia
11.
Medicine (Baltimore) ; 98(11): e14888, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30882703

RESUMO

BACKGROUND: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by swelling, pain, and synovial damage. Effective methods lack in the treatment of RA. A traditional prescription in use for thousands of years in China, Huangqi Guizhi Wuwutang granule (HGWG) is still chosen to relieve pain and prevent joint malformation in RA patients. However, no evidence-based medical research has been organized to assess the effectiveness and safety of HGWG for RA. METHODS/DESIGN: We will conduct a multicenter, randomized, double-blind, placebo-controlled clinical trial to determine whether HGWG can relieve pain and protect joints. We will randomly divide 120 patients with active RA into 2 groups, treated for 12 weeks. Main measurement is the rate of ACR50 score (American College of Rheumatology) from the baseline to 12 weeks. Secondary measurements include rate of ACR20/70, change of Disease Activity Score (DAS) 28, Health Assessment Questionnaire-Disability Index (HAQ-DI), Patient Assessment of Arthritis Pain, Patient Global Assessment of Arthritis, and AIS score. The time points are set as baseline, 2 weeks, 4 weeks, 8 weeks, 12 weeks, 24 weeks, and 48 weeks. In addition, the rate of ACR50 from the baseline to 2 weeks, 4 weeks, 8 weeks, 24 weeks, and 48 weeks' follow-up are also the secondary outcome measures. DISCUSSION: The findings of this research will elucidate the efficacy and safety of HGWG and provide an alternative treatment for RA. In addition, our data will benefit the clinical decision-making on active RA and possibly be incorporated into future guidelines. TRIAL REGISTRATION: ClinicalTrials.gov ID: NCT03593837.


Assuntos
Artrite Reumatoide/tratamento farmacológico , Medicina Herbária/normas , China , Cinnamomum aromaticum , Método Duplo-Cego , Medicamentos de Ervas Chinesas/uso terapêutico , Glycyrrhiza uralensis , Medicina Herbária/métodos , Humanos , Medicina Tradicional Chinesa/métodos , Medicina Tradicional Chinesa/normas , Placebos , Resultado do Tratamento
12.
J Crohns Colitis ; 13(6): 673-685e, 2019 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-30820529

RESUMO

Patients with inflammatory bowel disease [IBD] increasingly use alternative and complementary therapies, for which appropriate evidence is often lacking. It is estimated that up to half of all patients with IBD use various forms of complementary and alternative medicine during some point in their disease course. Considering the frequent use of such therapies, it is crucial that physicians and patients are informed about their efficacy and safety in order to provide guidance and evidence-based advice. Additionally, increasing evidence suggests that some psychotherapies and mind-body interventions may be beneficial in the management of IBD, but their best use remains a matter of research. Herein, we provide a comprehensive review of some of the most commonly used complementary, alternative and psychotherapy interventions in IBD.


Assuntos
Terapias Complementares , Doenças Inflamatórias Intestinais/terapia , Psicoterapia , Terapia Cognitivo-Comportamental/métodos , Terapias Complementares/métodos , Consenso , Suplementos Nutricionais , Europa (Continente) , Medicina Herbária/métodos , Humanos , Terapias Mente-Corpo/métodos , Psicoterapia/métodos , Sociedades Médicas
13.
Oxid Med Cell Longev ; 2019: 7202695, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30733853

RESUMO

Shepherd's purse (Capsella bursa-pastoris (L.) Medik.), a wild herb as a traditional herbal medicine, has been proved with multiple healthy benefits. In this study, the chemical constituents of shepherd's purse were identified by UPLC-QTOF-MS/MS. The antioxidative and anti-inflammatory potential of shepherd's purse extract (SPE) were also investigated applying lipopolysaccharide- (LPS-) induced inflammation in RAW 264.7 macrophages and a carrageenan-induced mice paw edema model. Twenty-four chemical compounds were identified mainly including phenolic acids and flavonoids. The data also indicated SPE inhibited the productions of NO, PGE2, TNF-α, and IL-6 stimulated with LPS. In addition, SPE inhibited the increase of reactive oxygen species (ROS) and upregulated the expression of heme oxygenase-1 (HO-1). We further found that SPE inhibited the phosphorylation of P38 MAPK and activation of NF-κB. In vivo mice model also indicated that SPE showed strong antioxidative and anti-inflammatory activity.


Assuntos
Anti-Inflamatórios/uso terapêutico , Antioxidantes/uso terapêutico , Heme Oxigenase-1/metabolismo , Medicina Herbária/métodos , NF-kappa B/metabolismo , Polifenóis/metabolismo , Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo , Animais , Anti-Inflamatórios/farmacologia , Antioxidantes/farmacologia , Modelos Animais de Doenças , Humanos , Camundongos
14.
Inflammopharmacology ; 27(2): 213-231, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30737607

RESUMO

BACKGROUND: Herbal medicine plays an important role in health, particularly in remote parts of developing areas with few health facilities. According to WHO estimates, about three-quarters of the world's population currently use herbs or traditional medicines to treat various ailments, including liver diseases. Several studies have found that the use of medicinal plants was effective in the treatment of infectious and non-infectious diseases. Hepatitis and liver cirrhosis associated with many clinical manifestations can be treated with allopathic medicines, but reports of a number of side effects including immunosuppression, bone marrow suppression, and renal complications have motivated researchers to explore more natural herbal medicines with low or no side effects and with high efficacy in treating hepatic diseases. METHODS: Databases including PubMed, Medline, and Google Scholar were searched for findings on the hepatoprotective effects of plants. RESULTS: Various medicinal plants are used for the treatment of liver disorders. The range of alternative therapies is huge, and they are used worldwide, either as part of primary health care or in combination with conventional medicine. Hepatoprotective plants contain a variety of chemical constituents including flavonoids, alkaloids, glycosides, carotenoids, coumarins, phenols, essential oil, organic acids, monoterpenes, xanthenes, lignans, and lipids. CONCLUSION: This review shows that numerous plants are found to contain hepatoprotective compounds. However, further studies are needed to determine their association with existing regimes of antiviral medicines and to develop evidence-based alternative medicine to cure different kinds of liver disease in humans.


Assuntos
Doença Crônica/tratamento farmacológico , Hepatopatias/tratamento farmacológico , Preparações de Plantas/farmacologia , Preparações de Plantas/uso terapêutico , Animais , Medicina Herbária/métodos , Humanos , Prevalência
15.
Medicine (Baltimore) ; 98(3): e14145, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30653148

RESUMO

BACKGROUND: This systematic review protocol describes the methods that will be used to evaluate the efficacy and safety of herbal medicine in treating traumatic brain injury. METHODS AND ANALYSIS: The following electronic databases will be searched up to December 2018 without language or publication status restrictions: Medline, EMBASE, the Cochrane Central Register of Controlled Trials, Allied and Complementary Medicine Database, and Cumulative Index to Nursing and Allied Health Literature. We will also search Korean, Chinese, and Japanese databases. Any randomized controlled trials related to herbal medicine for traumatic brain injury will be included. The functional outcome, consciousness state, morbidity, and mortality will be assessed as primary outcomes. The quality of life, adverse events, and total effective rate will be evaluated as secondary outcomes. Two researchers will independently perform the study selection, data extraction, assessment of study quality, and evaluation of the quality of evidence for the main findings. Data synthesis and analysis will be performed using RevMan version 5.3. The results will be expressed as a risk ratio for the binary outcome and as the mean difference or standardized mean difference for a continuous outcome. We will synthesize the data by either fixed effects or random effects model according to a heterogeneity test or the number of studies included in the meta-analysis. The methodological quality of the included studies will be evaluated using the Cochrane Collaboration's risk of bias tool. The quality of evidence for each main outcome will be evaluated using the Grading of Recommendations Assessment, Development, and Evaluation approach. ETHICS AND DISSEMINATION: Ethical approval is not required because individual patient data are not included. The findings of this systematic review will be disseminated through a peer-reviewed publication or conference presentations. PROSPERO REGISTRATION NUMBER: CRD42018116559.


Assuntos
Lesões Encefálicas Traumáticas/terapia , Medicina Herbária/métodos , Fitoterapia/métodos , Lesões Encefálicas Traumáticas/reabilitação , Humanos , Fitoterapia/efeitos adversos , Plantas Medicinais/efeitos adversos , Plantas Medicinais/efeitos dos fármacos , Qualidade de Vida , Projetos de Pesquisa , Resultado do Tratamento
16.
Complement Ther Med ; 42: 158-163, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30670237

RESUMO

BACKGROUND: In Africa, particularly Nigeria, there is an increasing interest in natural product remedies with a basic approach towards nature. This research studies the prevalence of use, pattern of use and awareness of outpatients at the University of Ilorin Teaching Hospital, Ilorin, Nigeria on the use of herbal medicines. METHODOLOGY: Based on an informed consent, semi-structured questionnaires were used to collect data from a total of 112 outpatients attending different outpatient clinics of the hospital about the use of herbs. This sample size was derived from the Kish formula. Data obtained were analyzed by IBM SPSS Statistics software V23 and inferences made accordingly. RESULTS: All (100.00%) of the outpatients were familiar with herbal medicines, 67.86% had used herbal medicines in the past and 25.00% were currently taking herbal medicines as at the time of study. It was also found that 54.35% of the respondents use herbal medicines in no specific dose, 47.83% use the herbs with various additives, and 39.13% take their herbs concurrently with orthodox medicines. A total of 13.73% of the respondents prefer to use herbs when sick and another 35.29% prefer a combination of herbs and orthodox medicines. CONCLUSIONS: Most of the patient-respondents prefer to include herbal medicines in their therapies. It is concerning that over one-third of the respondents concomitantly use herbal and orthodox medicines, some others use the herbs inappropriately. More efforts should be geared towards ensuring general improved use of herbal medicines.


Assuntos
Pacientes Ambulatoriais/psicologia , Fitoterapia/psicologia , Adulto , Idoso , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Medicina Herbária/métodos , Hospitais de Ensino/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Nigéria , Plantas Medicinais , Inquéritos e Questionários , Adulto Jovem
18.
Medicine (Baltimore) ; 98(1): e14016, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30608450

RESUMO

BACKGROUND: Postoperative pain is caused by surgical trauma and poses a significant challenge for health care providers. Opioid analgesics are commonly used to control postoperative pain. However, these drugs are associated with a number of negative side effects. This review will assess the clinical evidence for and against the use of herbal medicine formulas as a treatment for postoperative pain, especially after musculoskeletal surgery. METHODS: Twelve databases will be searched from inception to March 2019. We will include randomized controlled trials (RCTs) assessing herbal medicine decoctions used to treat any type of postoperative pain. All RCTs of decoctions or modified decoctions will be included. The methodologic qualities of the RCTs will be assessed using the Cochrane Collaboration tool for assessing risk of bias, while confidence in the cumulative evidence will be evaluated using the Grading of Recommendations Assessment, Development, and Evaluation method. CONCLUSION: This systematic review will be published in a peer-reviewed journal and disseminated electronically and in print. The review will be updated to inform and guide health care practices.Registration number: CRD42018094897.


Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Medicina Herbária/métodos , Sistema Musculoesquelético/cirurgia , Dor Pós-Operatória/tratamento farmacológico , Humanos , Dor Pós-Operatória/prevenção & controle , Estudos Prospectivos , Ensaios Clínicos Controlados Aleatórios como Assunto , Medição de Risco
19.
Medicine (Baltimore) ; 98(1): e14023, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30608454

RESUMO

BACKGROUND: Herbal medicine has been used to manage benign prostatic hyperplasia (BPH) and the associated lower urinary tract symptoms, but its effects are not yet fully understood. The purpose of this review is to assess the efficacy and safety of herbal medicine as a treatment for BPH. METHODS AND ANALYSIS: Thirteen databases will be searched for relevant studies from inception to the present date. We will include randomized controlled trials assessing herbal medicine for the treatment of BPH. The methodological qualities, including the risk of bias, will be evaluated using the Cochrane risk of bias assessment tool, while confidence in the cumulative evidence will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. ETHICS AND DISSEMINATION: Ethical approval is not required, as this study is based on the review of published research. This review will be published in a peer-reviewed journal and disseminated both electronically and in print.


Assuntos
Medicina Herbária/métodos , Sintomas do Trato Urinário Inferior/tratamento farmacológico , Hiperplasia Prostática/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Humanos , Sintomas do Trato Urinário Inferior/epidemiologia , Masculino , Pessoa de Meia-Idade , Prevalência , Hiperplasia Prostática/epidemiologia , Ensaios Clínicos Controlados Aleatórios como Assunto , Projetos de Pesquisa , Resultado do Tratamento
20.
J Zhejiang Univ Sci B ; 20(1): 9-22, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30614226

RESUMO

OBJECTIVE: The aim of this study is to summarize preclinical studies on herbal medicines used to treat cancer cachexia and its underlying mechanisms. METHODS: We searched four representing databases, including PubMed, EMBASE, the Allied and Complementary Medicine Database, and the Web of Science up to December 2016. Randomized animal studies were included if the effects of any herbal medicine were tested on cancer cachexia. The methodological quality was evaluated by the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADE) checklist. RESULTS: A total of fourteen herbal medicines and their compounds were identified, including Coptidis Rhizoma, berberine, Bing De Ling, curcumin, Qing-Shu-Yi-Qi-Tang, Scutellaria baicalensis, Hochuekkito, Rikkunshito, hesperidin, atractylodin, Sipjeondaebo-tang, Sosiho-tang, Anemarrhena Rhizoma, and Phellodendri Cortex. All the herbal medicines, except curcumin, have been shown to ameliorate the symptoms of cancer cachexia through anti-inflammation, regulation of the neuroendocrine pathway, and modulation of the ubiquitin proteasome system or protein synthesis. CONCLUSIONS: This study showed that herbal medicines might be a useful approach for treating cancer cachexia. However, more detailed experimental studies on the molecular mechanisms and active compounds are needed.


Assuntos
Caquexia/tratamento farmacológico , Neoplasias Experimentais/tratamento farmacológico , Fitoterapia/métodos , Animais , Caquexia/etiologia , Medicina Herbária/métodos , Medicina Herbária/tendências , Medicina Tradicional do Leste Asiático/métodos , Medicina Tradicional do Leste Asiático/tendências , Neoplasias Experimentais/complicações , Fitoterapia/tendências
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