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1.
Rev Med Suisse ; 16(716): 2306-2309, 2020 Nov 25.
Artigo em Francês | MEDLINE | ID: mdl-33237652

RESUMO

Pediatric chronic pain is an increasingly recognized condition in children and adolescents. Current treatment is based on the bio-psycho-social model of chronic pain: an interprofessional and integrative team will help the young patient and his environment, in order to find a balance between physical, psychological and social impacts. This article focuses on different treatment approaches for pediatric chronic pain in the outpatient and inpatient setting.


Assuntos
Dor Crônica/terapia , Medicina Integrativa/métodos , Pediatria/métodos , Adolescente , Criança , Humanos
2.
Med Care ; 58 Suppl 2 9S: S116-S124, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32826781

RESUMO

BACKGROUND: Long-term opioid therapy for chronic pain arose amid limited availability and awareness of other pain therapies. Although many complementary and integrative health (CIH) and nondrug therapies are effective for chronic pain, little is known about CIH/nondrug therapy use patterns among people prescribed opioid analgesics. OBJECTIVE: The objective of this study was to estimate patterns and predictors of self-reported CIH/nondrug therapy use for chronic pain within a representative national sample of US military veterans prescribed long-term opioids for chronic pain. RESEARCH DESIGN: National two-stage stratified random sample survey combined with electronic medical record data. Data were analyzed using logistic regressions and latent class analysis. SUBJECTS: US military veterans in Veterans Affairs (VA) primary care who received ≥6 months of opioid analgesics. MEASURES: Self-reported use of each of 10 CIH/nondrug therapies to treat or cope with chronic pain in the past year: meditation/mindfulness, relaxation, psychotherapy, yoga, t'ai chi, aerobic exercise, stretching/strengthening, acupuncture, chiropractic, massage; Brief Pain Inventory-Interference (BPI-I) scale as a measure of pain-related function. RESULTS: In total, 8891 (65%) of 13,660 invitees completed the questionnaire. Eighty percent of veterans reported past-year use of at least 1 nondrug therapy for pain. Younger age and female sex were associated with the use of most nondrug therapies. Higher pain interference was associated with lower use of exercise/movement therapies. Nondrug therapy use patterns reflected functional categories (psychological/behavioral, exercise/movement, manual). CONCLUSIONS: Use of CIH/nondrug therapies for pain was common among patients receiving long-term opioids. Future analyses will examine nondrug therapy use in relation to pain and quality of life outcomes over time.


Assuntos
Analgésicos Opioides/uso terapêutico , Dor Crônica/terapia , Terapias Complementares/estatística & dados numéricos , Medicina Integrativa/estatística & dados numéricos , Veteranos/estatística & dados numéricos , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Analgésicos Opioides/administração & dosagem , Dor Crônica/tratamento farmacológico , Terapias Complementares/métodos , Feminino , Nível de Saúde , Humanos , Medicina Integrativa/métodos , Masculino , Pessoa de Meia-Idade , Manejo da Dor , Percepção da Dor , Qualidade de Vida , Fatores Sexuais , Fatores Socioeconômicos , Estados Unidos , United States Department of Veterans Affairs , Saúde dos Veteranos
3.
J Altern Complement Med ; 26(8): 691-700, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32640830

RESUMO

Purpose: Chronic pain is a growing problem among children and adolescents, and is more prevalent in low-income families. This observational study was conducted to describe the demographics and various descriptors, complementary medicine therapy (CMT) use, and lifestyle factors (i.e., food habits and supplement use) of pediatric patients with chronic pain. Methods: Boston Medical Center's Interdisciplinary Pediatric Pain Clinic provides patient education and unique treatment plans, tailored with medical and nonpharmacologic interventions for managing complex and chronic pain. Patient data were obtained through electronic medical chart review and self-reported surveys, and were completed by participants and parents at enrollment. Results: Of the 83 participants, the average age was 15.4 ± 4.3, and 80% were female. Referrals to the clinic were due to abdominal pain (52%), headache (23%), and musculoskeletal or other pain (25%). Thirty-one percent were on food assistance programs, with only 24% of patients currently using CMTs and 85% using pain medications. More than half of all participants (63%) missed up to 5 days of school in the past year, while 26% missed more than 6 days. School or academics (77%) were the most frequently self-reported stressor, followed by social/peer issues (39%), bullying (18%), and parental stress (18%). A very small proportion of patients had sufficient intake of dairy (12%), water (23%), vegetables (1%), and fruits (22%). Conclusion: Chronic pain can significantly affect lifestyle factors, stress, and child development. Patients evaluated at the clinic had poor diets and report having stressors regarding school, social/peer issues, parental stress, and bullying.


Assuntos
Comportamento Infantil , Dor Crônica/terapia , Terapias Complementares/métodos , Comportamento Alimentar , Medicina Integrativa/métodos , Adolescente , Criança , Feminino , Humanos , Masculino , Clínicas de Dor , Apoio Social , Adulto Jovem
4.
Medicine (Baltimore) ; 99(21): e20083, 2020 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-32481274

RESUMO

We developed a protocol for a prospective registry to prove the effectiveness and safety of integrative Korean medicine treatment for inpatients with sciatica due to lumbar intervertebral disc herniation. We plan on recruiting 1000 inpatients receiving integrative Korean medicine treatment for lumbar intervertebral disc herniation at four spine specialized Korean medical hospitals. Patients enrolled in the registry will be evaluated at the time of hospitalization, 2 weeks after hospitalization, at discharge, and 6 months after hospitalization on predefined outcome variables such as intensity of back and leg pain, Oswestry Disability Index, quality of life, Patient Global Impression of Change, and adverse effects. The protocol of this study was registered in CRIS (KCT0003709) and Clinical trial gov (NCT03750591). This study is significant in that it cannot only be a basis for safety-related evidence of complementary alternative medicine, which has been lacking, but it also gives clear evidence on the effectiveness and validity of treatment effects such as accompaniment of stenosis, sex, age, and type of disc herniation.


Assuntos
Medicina Integrativa/métodos , Deslocamento do Disco Intervertebral/terapia , Medicina Tradicional Coreana/métodos , Ciática/terapia , Terapia por Acupuntura/métodos , Adulto , Idoso , Humanos , Deslocamento do Disco Intervertebral/complicações , Pessoa de Meia-Idade , Estudos Observacionais como Assunto , Estudos Prospectivos , Sistema de Registros , República da Coreia , Ciática/etiologia , Resultado do Tratamento , Adulto Jovem
5.
São Paulo; BIREME/OPAS/OMS; maio 29, 2020.
Não convencional em Inglês, Espanhol, Português | PIE | ID: biblio-1097703

RESUMO

O mapa apresenta uma visão geral das evidências sobre os efeitos da Meditação para diversas condições clínicas e de saúde da população em geral. A partir de uma ampla busca bibliográfica de estudos publicados e não publicados, foram incluídos no Mapa 191 revisões (78 revisões sistemáticas, 110 metanálises, 2 metassínteses e 1 revisão integrativa). Sobre os tipos de meditação: 147 revisões avaliaram resultados a partir de técnicas de mindfulness ou derivados, 34 revisões avaliaram meditação geral, 8 revisões meditação transcendental, 3 revisões técnicas de compaixão e 1 revisão avaliou práticas de atenção focada. Todos os estudos foram selecionados, avaliados, caracterizados e categorizados por pares de pesquisadores da área de Meditação.


El mapa muestra una vista general de las experiencias sobre los efectos de la meditación para diversas condiciones clínicas y de la salud de la población en general. A partir de una amplia búsqueda bibliográfica de estudios publicados y no publicados, fueron incluidas 191 revisiones: 78 revisiones sistemáticas, 110 metanálises, 2 metassínteses y 1 revisión integrativa. Sobre los tipos de meditación: 147 revisiones disponibles resultados de partir de técnicas de mindfulness o derivados, 34 revisiones disponibles meditación general, 8 revisiones medita trascendental, 3 revisiones técnicas de comparación y 1 revisión acerca prática de atención focada. Todos los estudios fueron seleccionados, evaluados, y caracterizados por pares de investigadores del área de Meditación.


The map provides an overview of the evidence on the effects of Meditation for various clinical and health conditions of the general population. From a wide bibliographic search of published and unpublished studies, 191 reviews were included in the Map: 78 systematic reviews, 110 meta-analyzes, 2 meta-syntheses and 1 integrative review. About types of meditation: 147 reviews evaluated results for mindfulness techniques or derivatives, 34 reviews evaluated general meditation, 8 reviews transcendental meditation, 3 compassion technique and 1 review evaluated practices of focused attention. All studies were selected, evaluated, characterized and categorized by pairs of researchers in the area of ​​Meditation.


Assuntos
Humanos , Resultado do Tratamento , Meditação/métodos , Medicina Baseada em Evidências/estatística & dados numéricos , Medicina Integrativa/métodos
6.
Complement Ther Med ; 49: 102333, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32147065

RESUMO

OBJECTIVE: Sickle Cell Disease (SCD) is an inherited blood disorder that includes acute pain episodes and chronic pain that can dramatically impact quality of life and goal-achievement. Our staff had limited success in connecting families with the Pain, Palliative Care and Integrative Medicine Clinic (PPCIM) to receive specialized skills for pain management. We created a partnership between Hematology and PPCIM to provide SCD patients/families with needed resources. DESIGN/SETTING: In 2016, key stakeholders collaborated to create a Sickle Cell Wellness Clinic (SCWC) clinic to provide families access to integrative medicine and wellness strategies. Design/structure, based on family focus group data and staff expertise, included a half-day, 7-discipline clinic housed in the PPCIM space. Patients with SCD, ages 8-20, learned strategies in an effort to improve health care utilization and increase overall quality of life. MAIN OUTCOME MEASURES/RESULTS: Feedback from two successful pilot clinics in 2017 was incorporated into the formal roll-out of SCWC in 2018. SCWCs continued monthly for one year, serving a total of 20 families post-pilot. SCD patients increased follow-up appointment engagement in the PPCIM clinic following SCWC and reported high levels of satisfaction with their healthcare experience. CONCLUSIONS: It is feasible to run a multidisciplinary clinic focused on pain management, coping skills, and healthy living with SCD. Providers benefited from the opportunity to collaborate with other disciplines. Patient and family feedback was positive, highlighted benefits of being introduced to new modalities, and reported advantages of meeting other patients/families in a new setting.


Assuntos
Anemia Falciforme/terapia , Medicina Integrativa/métodos , Manejo da Dor/métodos , Equipe de Assistência ao Paciente , Preferência do Paciente , Adolescente , Criança , Feminino , Humanos , Masculino , Clínicas de Dor , Projetos Piloto , Qualidade de Vida , Inquéritos e Questionários
7.
Am J Gastroenterol ; 115(3): 350-364, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32079860

RESUMO

The relevance of functional gastrointestinal (GI) disorders and their impact on quality of life for many patients has become an increasingly important topic in gastroenterology. A gastroenterologist can expect to see 40% of patients for motility and functional GI disorders, thus highlighting the necessity for physicians to have a strong foundation of knowledge in treatment strategies for these patients with complex disorders. A significant number of patients who suffer with functional GI disorders turn to complementary and alternative therapies to maintain control over their symptoms and often are happy with therapeutic results. This narrative presents information and treatment algorithms for the gastroenterologist to better understand and use some of the most common complementary and alternative therapies for patients with functional dyspepsia, nausea and vomiting, and irritable bowel syndrome.


Assuntos
Terapias Complementares/métodos , Gastroenterologia/métodos , Gastroenteropatias/terapia , Medicina Integrativa/métodos , Humanos , Satisfação do Paciente , Relações Médico-Paciente
8.
Medicina (Kaunas) ; 56(1)2020 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-31963617

RESUMO

This review aimed to identify the potential role of integrative medicine in interventional oncology. The music therapy; stress management techniques; guided imagery, including virtual reality; clinical hypnosis; and digital sedation may all be efficient on anxiety and pain during procedures performed in interventional oncology. Beyond pharmacological sedation, the implementation of integrative medicine to interventional oncology may, therefore, improve the support and care of cancer patients, which may further create a virtuous alliance.


Assuntos
Dor do Câncer/terapia , Medicina Integrativa/métodos , Oncologia/métodos , Neoplasias/terapia , Equipe de Assistência ao Paciente , Humanos
11.
BMC Public Health ; 19(1): 1623, 2019 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-31795983

RESUMO

BACKGROUND: Integrative medicine (IM) is a patient-centered, evidence-based, therapeutic paradigm which combines conventional and complementary approaches. The use of IM in pediatrics has increased in the past two decades and parents' demand for it is growing. An IM whole systems approach is anthroposophic medicine. Considering the growing demand for integrative approaches in children, it is relevant from a public health perspective to find out which kind of children use IM in Germany and whether they differ from the entirety of pediatric inpatients in Germany. Moreover, it would be interesting to known, whether these patients are willing to travel a longer distance to gain integrative treatment. METHODS: The present study investigates the standard ward documentation datasets of 29,956 patients of all German integrative anthroposophic pediatric inpatient wards from 2005 to 2016 and compares them systematically to collect data of the entirety of all pediatric inpatient wards in Germany. Apart from patients' age and gender, and the ICD-10 admission diagnoses, the geographical catchment area of the hospitals were analyzed. RESULTS: Sociodemographic characteristics of pediatric inpatients in the integrative anthroposophic departments (IAH) did not differ from the entirety of all pediatric inpatients. Regarding clinical characteristics, higher frequencies were found for endocrine, nutritional and metabolic diseases (IAH: 7.24% vs. 2.98%); mental, behavioral, and neurodevelopmental disorders (IAH: 9.83% vs. 3.78%) and nervous diseases (IAH: 8.82% vs. 5.16%) and lower frequencies for general pediatric diseases such as respiratory diseases (IAH: 17.06% vs. 19.83%), digestive diseases (IAH: 3.90% vs. 6.25%), and infectious and parasitic diseases (IAH: 12.88% vs. 14.82%) in comparison to the entirety of all pediatric inpatients in Germany. The IAH showed a broad catchment area, with most patients being from former, Western federal republic of Germany. Large catchment areas (> 100 km) for the IAH are merely covered by severe and chronic diseases. CONCLUSION: Pediatric inpatients of IAH do not differ from the entirety of pediatric inpatients in Germany regarding sociodemographic characteristics but show differences regarding clinical characteristics. Parents are willing to travel further distance to get specialized integrative anthroposophic medical care for children with severe and chronic diseases.


Assuntos
Antroposofia , Departamentos Hospitalares/estatística & dados numéricos , Pacientes Internados/estatística & dados numéricos , Medicina Integrativa/estatística & dados numéricos , Pediatria/estatística & dados numéricos , Adolescente , Área Programática de Saúde , Criança , Doença Crônica/terapia , Feminino , Alemanha , Acesso aos Serviços de Saúde , Humanos , Medicina Integrativa/métodos , Masculino , Pediatria/métodos
12.
PLoS One ; 14(12): e0225540, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31851666

RESUMO

BACKGROUND: Current treatment options for chronic pain and depression are largely medication-based, which may cause adverse side effects. Integrative Medical Group Visits (IMGV) combines mindfulness techniques, evidence based integrative medicine, and medical group visits, and is a promising adjunct to medications, especially for diverse underserved patients who have limited access to non-pharmacological therapies. OBJECTIVE: Determine the effectiveness of IMGV compared to a Primary Care Provider (PCP) visit in patients with chronic pain and depression. DESIGN: 9-week single-blind randomized control trial with a 12-week maintenance phase (intervention-medical groups; control-primary care provider visit). SETTING: Academic tertiary safety-net hospital and 2 affiliated federally-qualified community health centers. PARTICIPANTS: 159 predominantly low income racially diverse adults with nonspecific chronic pain and depressive symptoms. INTERVENTIONS: IMGV intervention- 9 weekly 2.5 hour in person IMGV sessions, 12 weeks on-line platform access followed by a final IMGV at 21 weeks. MEASUREMENTS: Data collected at baseline, 9, and 21 weeks included primary outcomes depressive symptoms (Patient Health Questionnaire 9), pain (Brief Pain Inventory). Secondary outcomes included pain medication use and utilization. RESULTS: There were no differences in pain or depression at any time point. At 9 weeks, the IMGV group had fewer emergency department visits (RR 0.32, 95% CI: 0.12, 0.83) compared to controls. At 21 weeks, the IMGV group reported reduction in pain medication use (Odds Ratio: 0.42, CI: 0.18-0.98) compared to controls. LIMITATIONS: Absence of treatment assignment concealment for patients and disproportionate group attendance in IMGV. CONCLUSION: Results demonstrate that low-income racially diverse patients will attend medical group visits that focus on non-pharmacological techniques, however, in the attention to treat analysis there was no difference in average pain levels between the intervention and the control group. TRIAL REGISTRATION: clinicaltrials.gov NCT02262377.


Assuntos
Dor Crônica/terapia , Depressão/terapia , Medicina Integrativa/métodos , Atenção Plena/métodos , Visita a Consultório Médico , Centros Médicos Acadêmicos/organização & administração , Adulto , Idoso , Idoso de 80 Anos ou mais , Dor Crônica/diagnóstico , Dor Crônica/psicologia , Centros Comunitários de Saúde/organização & administração , Depressão/diagnóstico , Depressão/psicologia , Feminino , Humanos , Medicina Integrativa/organização & administração , Masculino , Pessoa de Meia-Idade , Medição da Dor , Questionário de Saúde do Paciente , Atenção Primária à Saúde/métodos , Atenção Primária à Saúde/organização & administração , Provedores de Redes de Segurança/organização & administração , Índice de Gravidade de Doença , Método Simples-Cego , Centros de Atenção Terciária/organização & administração , Resultado do Tratamento , Adulto Jovem
13.
Cancer J ; 25(5): 343-348, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31567462

RESUMO

Pain management for cancer patients should include pharmacologic and nonpharmacologic interventions. Integrative medicine therapies, such as mind-body practice, acupuncture, massage therapy, and music therapy, have been studied for their roles in pain management. Data from randomized controlled trials support the effect of hypnosis, acupuncture, and music therapy in reduction of pain. Mindfulness meditation, yoga, qigong, and massage therapy, although may not reduce pain per se, can relieve anxiety and mood changes, which are commonly associated with pain. In clinical practice, one should also consider burdens and risks to patients, patient preference, and the presence or absence of better alternatives when making decisions on whether an integrative medicine therapy is of clinical value.


Assuntos
Dor do Câncer/etiologia , Dor do Câncer/terapia , Medicina Integrativa , Neoplasias/complicações , Manejo da Dor , Acupuntura , Terapia Combinada , Terapias Complementares , Gerenciamento Clínico , Humanos , Medicina Integrativa/métodos , Terapias Mente-Corpo/métodos , Neoplasias/terapia
14.
Cancer J ; 25(5): 349-356, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31567463

RESUMO

Cancer-related fatigue (CRF) is a common symptom for which cancer patients often use integrative and integrative therapies; however, evidence supporting these therapies is limited. The aim of this review is to provide evidence-based recommendations for integrative interventions during and after cancer treatment for CRF. These recommendations are based on a systematic literature review from 1990 through 2019. Cognitive behavior therapy plus hypnosis and American ginseng can be considered during active treatment, and acupressure, mindfulness-based cognitive therapy, and qigong/tai chi easy can be considered during posttreatment. Coenzyme Q10 and L-carnitine are not recommended during active-treatment. All other integrative therapies for CRF had insufficient evidence to make a recommendation. While there is increasing evidence for integrative therapies for CRF, because of lack of rigorous trials and replication, no therapies could be definitively recommended. Further rigorously designed integrative therapy research is needed and should consider implementation and dissemination.


Assuntos
Terapias Complementares , Fadiga/etiologia , Fadiga/terapia , Medicina Integrativa , Neoplasias/complicações , Terapias Complementares/métodos , Gerenciamento Clínico , Humanos , Medicina Integrativa/métodos , Resultado do Tratamento
15.
Complement Ther Clin Pract ; 37: 73-85, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31521007

RESUMO

BACKGROUND: This case series describes the survival outcomes of patients who underwent integrative medicine (IM) protocol for ovarian cancer, a treatment protocol, that integrated a carefully selected set of complementary and alternative medicine (CAM) into the conventional treatment for ovarian cancers. MATERIALS AND METHODS: Retrospective review of patients' medical records was conducted at a private medical centre that delivered the IM protocol for patients with advanced and recurrent ovarian cancers. We explored and analysed the overall survival and disease progressions of those who received the IM treatment for at least 2 months. RESULTS: Forty patients with advanced ovarian cancers fulfilled the inclusion criteria for this case series. An overall of 75% of the cases achieved remission with initial IM treatment, 17.5% had a partial response and 7.5% showed progressive disease. The overall 5-year survival for all 40 cases is 53.1%. When explored further, the 5-year survival for cases who received CAM only is 75%, and cases who received combined limited chemotherapy with CAM had a 5-year survival of 55%. At study endpoint, 11 cases died due to ovarian cancer. CONCLUSION: These findings suggest that CAM may be a valuable addition to conventional therapy to treat and improve the survival of patients with ovarian cancers. A formal randomized control trial is required to evaluate the efficacy and long-term outcomes of using IM to treat advanced and recurrent ovarian cancers.


Assuntos
Medicina Integrativa/métodos , Neoplasias Ovarianas/terapia , Adulto , Feminino , Humanos , Malásia , Pessoa de Meia-Idade , Estudos Retrospectivos , Taxa de Sobrevida , Adulto Jovem
16.
Fam Process ; 58(4): 796-818, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31518458

RESUMO

Old resentments and unfinished business from the family of origin can constrain adults in current relationships with parents or siblings and negatively affect relationships with partners or children. This article explores how old wounds get reactivated in current relationships and contribute to the intergenerational transmission of painful legacies and trauma. Building on intergenerational family theory and interpersonal neurobiology, the dynamics of reactivity and pathways for growth are explored. While much of the time the human brain is on autopilot, driven by habits and emotional reactivity, we are capable of bringing prefrontal thoughtfulness and choice to close relationships. Rather than being victims of parents or our past, we can become authors of our own relational life. Interventions are offered to help adult clients "wake from the spell of childhood," heal intergenerational wounds, and "grow up" relationships with family of origin. The damage caused by parent-blaming in therapy is explored and contrasted with Ivan Boszormenyi-Nagy's emphasis on rejunctive action and cultivating resources of trustworthiness in intergenerational relationships. The family is considered both in its cultural context-including stressors and resources for resilience-and in its life cycle context. Aging in the intergenerational family is discussed, focusing on ways adult children and their parents can grow and flourish with the challenges at this time of life. Throughout, the theme of relational ethics-how we can live according to our values and "reach for our best self" in intergenerational relationships-informs the discussion.


Assuntos
Crianças Adultas/psicologia , Terapia Familiar/métodos , Relação entre Gerações , Neurobiologia/métodos , Relações Pais-Filho , Adulto , Feminino , Humanos , Medicina Integrativa/métodos , Masculino
17.
Integr Cancer Ther ; 18: 1534735419866908, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31416372

RESUMO

The Standardized Cultured Extract of Lentinula edodes Mycelia (also known as Active Hexose Correlated Compound, AHCC) and Wasabia japonica (Wasabi) are natural nutritional supplements known for their immunomodulatory and anticancer potential. The aim of this study was to evaluate the combinatorial effect of the bioactive immunomodulatory compound (BAIC), obtained by combining Wasabi and AHCC, on human breast (MCF-7) and pancreatic (Panc02) adenocarcinoma cell lines. Data obtained revealed that BAIC determines a striking decline in cancer cell growth at minimal concentrations compared with the use of Wasabi and AHCC as single agents. A significant increase in the G0/G1 subpopulation together with a marked augmentation in the percentage of apoptotic cells was demonstrated by flow cytometry, together with a significant upregulation in the expression of genes associated to the apoptotic cascade in both cell lines. The inhibitory role BAIC plays in mammospheres formation from MCF-7-derived cancer stem cells was shown with a marked reduction in size and number. Interestingly, when BAIC was exposed to monocytic cells, no cytotoxic effects were observed. A monocytes-to-macrophages differentiation was rather observed with the concomitant acquisition of an anti-inflammatory phenotype. Taken together, our findings suggest that BAIC could be used as a potential integration of standard chemotherapy treatments because of the improved inhibitory activity on cancer cell proliferation and reduced potential adverse effects.


Assuntos
Adenoma/tratamento farmacológico , Antineoplásicos/farmacologia , Neoplasias da Mama/tratamento farmacológico , Fatores Imunológicos/farmacologia , Neoplasias Pancreáticas/tratamento farmacológico , Apoptose/efeitos dos fármacos , Diferenciação Celular/efeitos dos fármacos , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Feminino , Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos , Humanos , Medicina Integrativa/métodos , Células MCF-7 , Macrófagos/efeitos dos fármacos , Oncologia/métodos , Monócitos/efeitos dos fármacos
18.
J Altern Complement Med ; 25(7): 719-726, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31314560

RESUMO

Objectives: To use a psychosocial framework to examine the pain experiences of low-income, ethnically diverse patients before and after an Integrative Pain Management Program (IPMP). Design and methods: IPMP is a 12-week, multimodal pain group incorporating mindfulness, acupuncture, massage, education, movement, and health coaching. The authors conducted semistructured interviews at the beginning, end, and 3 months following completion of IPMP. Interviews were digitally recorded and transcribed and analyzed using inductive coding methods. Setting: A primary care clinic in San Francisco, CA, serving low-income, ethnically diverse patients, many of whom are marginally housed and living with disabilities. Subjects: Forty-one patients with a diagnosis of chronic pain, currently receiving prescription opioids and referred by their primary care provider, who participated in IPMP. Results: Authors thematically analyzed 104 individual interviews with 41 IPMP participants, including 41 baseline, 35 three-month follow-up, and 28 six-month follow-up. Before IPMP, participants described a psychologic "vicious cycle" of pain symptoms that worsened with movement and anxiety, while increasing their sense of disempowerment and social isolation. Following IPMP, patients reported using new strategies to manage pain, including lowering medication use, resulting in an emerging sense of psychologic resilience, and more social connections. Conclusions: IPMP offers an accessible model for addressing psychosocial aspects of chronic pain. Vulnerable patients engaged with integrative medicine groups and developed new perspectives and tools for managing their pain; they emerged feeling hopeful and resilient. These results support the use of integrative medicine groups for targeting psychosocial aspects of chronic pain within primary care.


Assuntos
Dor Crônica , Medicina Integrativa/métodos , Manejo da Dor/psicologia , Consultas Médicas Compartilhadas , Populações Vulneráveis/psicologia , Dor Crônica/psicologia , Dor Crônica/terapia , Terapias Complementares , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
19.
J Spec Pediatr Nurs ; 24(3): e12260, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31286631

RESUMO

PURPOSE: We aimed to determine the complementary and integrative health (CIH) methods used by parents to treat oral mucositis in their children who have cancer. DESIGN AND METHODS: In this multicenter, cross-sectional study, data for the study were collected via the demographic form and CIH form for oral mucositis. The data collection tools were filled out by the researchers during the face-to-face interviews. The parents (N = 302) of children with cancer who had undergone at least one round of chemotherapy were included in this study. RESULTS: According to the parents' statements, oral mucositis developed in 91.1% of the children with cancer, and CIH was used in 50.9% of them to treat its side effects. Parents stated that to deal with the oral mucositis, they mainly used black mulberry (41.5%), carbonate (15.2%), and honey (11.6%). Some of the parents (51.8%) used CIH for their children without informing their healthcare providers. PRACTICE IMPLICATIONS: The majority of healthcare providers were unaware of the parents' use of CIH for their children's oral mucositis treatment. Parents' opinions of these methods, of which the side effects and potential interactions with chemotherapeutic agents are not precisely known, and their use by parents for their children's oral mucositis should be evaluated by healthcare providers.


Assuntos
Terapias Complementares/métodos , Neoplasias/complicações , Neoplasias/terapia , Estomatite/terapia , Inquéritos e Questionários , Adolescente , Adulto , Criança , Pré-Escolar , Estudos Transversais , Feminino , Pessoal de Saúde , Humanos , Medicina Integrativa/métodos , Neoplasias/patologia , Pais/psicologia , Estomatite/etiologia , Resultado do Tratamento , Turquia
20.
Curr Hematol Malig Rep ; 14(4): 328-336, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31209644

RESUMO

PURPOSE OF REVIEW: This review discusses the emerging role of integrative hematology. It reinforces the growing interest of CAM among patients, and the importance of provider knowledge and participation in discussions with patients about the subject. The main question asked in this review, "Is there evidence for the use of integrative medicine practices in the field of malignant hematology?" is answered by examining current research and providing relevant summaries. RECENT FINDINGS: Data suggests that practices such as meditative movement, exercise, nutrition and supplements and touch therapy can be used for symptom alleviation, preventive measures, and novel treatment development. Integrative hematology is a needed part of complete patient care, and it is the role of providers to be knowledgeable and open to ensure patients are engaging in practices that are evidence-informed and safe. More studies are needed in the field in order to make concrete and robust recommendations.


Assuntos
Neoplasias Hematológicas/terapia , Medicina Integrativa , Ensaios Clínicos como Assunto , Terapia Combinada/métodos , Terapias Complementares/métodos , Prestação Integrada de Cuidados de Saúde , Gerenciamento Clínico , Neoplasias Hematológicas/patologia , Humanos , Medicina Integrativa/métodos , Resultado do Tratamento
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