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1.
Medicine (Baltimore) ; 99(36): e22038, 2020 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-32899061

RESUMO

The effectiveness of diethylenetriamine pentaacetic acid scan is regularly monitored for the assessment of any potential modifications in treatment responses or kidney functions in the pediatric population.This study attempts to compare the usefulness of diethylenetriamine pentaacetic acid and ultrasound imaging of renal disorders among paediatric patients.A retrospective observational study was conducted by enrolling 106 children. The demographic details such as: participant's age, gender, and the history of renal disease of each patient were recorded. Patients were administered radiopharmaceuticals in a fixed dose and were later subjected to computed tomography (CT) scan. The obtained data was analysed using descriptive statistics.Findings indicated increased sensitivity for CT (61.20%); whereas, a major decrease in specificity (23.68%) was observed. Comparison of Single-photon emission CT (SPECT) and CT findings revealed the increased sensitivity (90.90%) for ultrasound; whereas, there was a slight decrease in the specificity (40%) for SPECT. However, SPECT findings show 91% sensitivity among patients with 71.42% positive predictive value. Moreover, an increase in sensitivity for CT (61.20%), followed by a major decrease in specificity (23.68%) was observed.Ultrasonography has been proved to be the safest and the most effective method for the diagnosis and the treatment of most renal disorders, due to the higher predictive value of SPECT scans. It is thus suggested that patients with ureteral calculi should be diagnosed with renal scintigraphy and unenhanced helical computerized tomography.


Assuntos
Nefropatias/diagnóstico por imagem , Ácido Pentético/administração & dosagem , Cintilografia/métodos , Ultrassonografia/métodos , Cálculos Ureterais/diagnóstico por imagem , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Nefropatias/fisiopatologia , Masculino , Medicina Nuclear/métodos , Valor Preditivo dos Testes , Compostos Radiofarmacêuticos/administração & dosagem , Estudos Retrospectivos , Sensibilidade e Especificidade , Tomografia Computadorizada de Emissão de Fóton Único/métodos , Tomografia Computadorizada por Raios X/métodos
2.
Hell J Nucl Med ; 23 Suppl: 6-7, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32860389

RESUMO

Nearly 19.9 million cases and more than 730 thousand disease-related deaths have been confirmed in the months that followed WHO's assessment that the novel coronavirus COVID-19, first emerged in Wuhan China on December 2019, could be characterized as a pandemic. The aforementioned coronavirus affected 188 countries as of 8.10.2020. Despite the continually increasing number of COVID-19 cases reported to CDC, at national level, the percentage of visits to outpatient providers and emergency departments has decreased and mortality rates attributed to COVID-19 have declined compared to the previous weeks, still above the baseline. It is common knowledge that the coronavirus pandemic has reshaped societies and economies around the globe, affecting all aspects of everyday life. Public health systems as a whole have been globally affected since they had to face extraordinary demands over a long period of time, which, in turn, required rapid adjustments in the operating procedures that were already in use, in order to provide high-standard health services, while respecting patients quality of life. Over half of deaths in low-income countries are caused by communicable diseases, maternal causes, conditions arising during pregnancy and childbirth, and nutritional deficiencies. On the contrary, this percentage is less than 7% in high-income countries. Noncommunicable diseases cause 71% of deaths globally, ranging from 37% in low-income countries to 88% in high-income countries. However, in terms of absolute number of deaths, 78% of global NCD deaths occurred in low-and middle-income countries. This partially explains why recent developments in medicine were mostly focused on chronic illnesses, including cardiovascular disease, cancer, chronic respiratory diseases and type 2 diabetes, rather than focusing on infection and inflammation progress. The COVID-19 pandemic and the subsequent burden it placed upon health systems to deal with infectious and non-infectious diseases in a poor environment, can become an opportunity to update the field of medical research and change the governmental policies in place that have been stagnant and/or inefficient and ill-managed. This way, health systems will be equipped with better and faster protocols and best practices in order to manage efficiently any other pandemic that might emerge in the future. In this context, Nuclear Medicine departments should reconsider and update their practices, by altering routines and workflows in order to comply with the new sanitary standards, triaging their appointments, or introducing new diagnostic methods like Tele-Medicine / Tele Nuclear Medicine and Artificial Intelligence applications. This special edition of Hellenic Journal of Nuclear Medicine has as its main purpose to introduce and communicate those new practices and protocols/standard operating procedures, in order for the scientific community, health public institutions, affected individuals and their families to be duly informed.


Assuntos
Infecções por Coronavirus/diagnóstico por imagem , Medicina Nuclear/normas , Pneumonia Viral/diagnóstico por imagem , Infecções por Coronavirus/epidemiologia , Humanos , Medicina Nuclear/métodos , Pandemias , Pneumonia Viral/epidemiologia , Guias de Prática Clínica como Assunto
5.
Nuklearmedizin ; 59(3): 276-280, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: covidwho-38324

RESUMO

The current outbreak of coronavirus SARS-CoV-2 has reached multiple countries worldwide. While the number of newly diagnosed cases and fatalities is rising quickly, far-reaching measures were enacted to prevent further spread. Diagnosis relies on clinical presentation, exposure history, PCR using specimens from the respiratory tract together with computed tomography (CT) imaging. One of the hallmarks of a critical course of COVID-19 is the development of severe acute respiratory distress syndrome (ARDS). As management of COVID-19 can be considered a multi-disciplinary approach involving various medical specialties, we here review the first 18F-FDG-PET/CT scans of COVID-19 to discuss how Nuclear Medicine could contribute to management of this disease.


Assuntos
Infecções por Coronavirus/diagnóstico por imagem , Fluordesoxiglucose F18/farmacologia , Medicina Nuclear/métodos , Pneumonia Viral/diagnóstico por imagem , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Síndrome do Desconforto Respiratório do Adulto/diagnóstico por imagem , Betacoronavirus , Surtos de Doenças , Feminino , Humanos , Comunicação Interdisciplinar , Masculino , Pessoa de Meia-Idade , Medicina Nuclear/tendências , Pandemias , Reação em Cadeia da Polimerase
6.
Nuklearmedizin ; 59(3): 276-280, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: covidwho-65620

RESUMO

The current outbreak of coronavirus SARS-CoV-2 has reached multiple countries worldwide. While the number of newly diagnosed cases and fatalities is rising quickly, far-reaching measures were enacted to prevent further spread. Diagnosis relies on clinical presentation, exposure history, PCR using specimens from the respiratory tract together with computed tomography (CT) imaging. One of the hallmarks of a critical course of COVID-19 is the development of severe acute respiratory distress syndrome (ARDS). As management of COVID-19 can be considered a multi-disciplinary approach involving various medical specialties, we here review the first 18F-FDG-PET/CT scans of COVID-19 to discuss how Nuclear Medicine could contribute to management of this disease.


Assuntos
Infecções por Coronavirus/diagnóstico por imagem , Fluordesoxiglucose F18/farmacologia , Medicina Nuclear/métodos , Pneumonia Viral/diagnóstico por imagem , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Síndrome do Desconforto Respiratório do Adulto/diagnóstico por imagem , Betacoronavirus , Surtos de Doenças , Feminino , Humanos , Comunicação Interdisciplinar , Masculino , Pessoa de Meia-Idade , Medicina Nuclear/tendências , Pandemias , Reação em Cadeia da Polimerase
7.
Eur J Nucl Med Mol Imaging ; 47(7): 1620-1622, 2020 07.
Artigo em Inglês | MEDLINE | ID: covidwho-60388

RESUMO

In the global pandemic COVID-19, it is important for everyone including nuclear medicine personnel to know how to stop transmission and contain and prevent the spread of COVID-19. Here, we summarize our American College of Nuclear Medicine members' experiences from Wuhan, China; Singapore; and the USA, so to provide advice to the nuclear medicine personnel for their clinical practice and management strategies in responding to COVID-19.


Assuntos
Infecções por Coronavirus/epidemiologia , Pneumonia Viral/epidemiologia , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/normas , Betacoronavirus , China , Infecções por Coronavirus/prevenção & controle , Equipamentos e Provisões/normas , Humanos , Medicina Nuclear/métodos , Pandemias/prevenção & controle , Segurança do Paciente/normas , Recursos Humanos em Hospital , Pneumonia Viral/prevenção & controle , Serviço Hospitalar de Radiologia/normas , Singapura , Estados Unidos
9.
Nuklearmedizin ; 59(3): 276-280, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: covidwho-46804

RESUMO

The current outbreak of coronavirus SARS-CoV-2 has reached multiple countries worldwide. While the number of newly diagnosed cases and fatalities is rising quickly, far-reaching measures were enacted to prevent further spread. Diagnosis relies on clinical presentation, exposure history, PCR using specimens from the respiratory tract together with computed tomography (CT) imaging. One of the hallmarks of a critical course of COVID-19 is the development of severe acute respiratory distress syndrome (ARDS). As management of COVID-19 can be considered a multi-disciplinary approach involving various medical specialties, we here review the first 18F-FDG-PET/CT scans of COVID-19 to discuss how Nuclear Medicine could contribute to management of this disease.


Assuntos
Infecções por Coronavirus/diagnóstico por imagem , Fluordesoxiglucose F18/farmacologia , Medicina Nuclear/métodos , Pneumonia Viral/diagnóstico por imagem , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Síndrome do Desconforto Respiratório do Adulto/diagnóstico por imagem , Betacoronavirus , Surtos de Doenças , Feminino , Humanos , Comunicação Interdisciplinar , Masculino , Pessoa de Meia-Idade , Medicina Nuclear/tendências , Pandemias , Reação em Cadeia da Polimerase
10.
Nuklearmedizin ; 59(3): 276-280, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32259853

RESUMO

The current outbreak of coronavirus SARS-CoV-2 has reached multiple countries worldwide. While the number of newly diagnosed cases and fatalities is rising quickly, far-reaching measures were enacted to prevent further spread. Diagnosis relies on clinical presentation, exposure history, PCR using specimens from the respiratory tract together with computed tomography (CT) imaging. One of the hallmarks of a critical course of COVID-19 is the development of severe acute respiratory distress syndrome (ARDS). As management of COVID-19 can be considered a multi-disciplinary approach involving various medical specialties, we here review the first 18F-FDG-PET/CT scans of COVID-19 to discuss how Nuclear Medicine could contribute to management of this disease.


Assuntos
Infecções por Coronavirus/diagnóstico por imagem , Fluordesoxiglucose F18/farmacologia , Medicina Nuclear/métodos , Pneumonia Viral/diagnóstico por imagem , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Síndrome do Desconforto Respiratório do Adulto/diagnóstico por imagem , Betacoronavirus , Surtos de Doenças , Feminino , Humanos , Comunicação Interdisciplinar , Masculino , Pessoa de Meia-Idade , Medicina Nuclear/tendências , Pandemias , Reação em Cadeia da Polimerase
12.
Eur J Nucl Med Mol Imaging ; 47(7): 1620-1622, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32296884

RESUMO

In the global pandemic COVID-19, it is important for everyone including nuclear medicine personnel to know how to stop transmission and contain and prevent the spread of COVID-19. Here, we summarize our American College of Nuclear Medicine members' experiences from Wuhan, China; Singapore; and the USA, so to provide advice to the nuclear medicine personnel for their clinical practice and management strategies in responding to COVID-19.


Assuntos
Infecções por Coronavirus/epidemiologia , Pneumonia Viral/epidemiologia , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/normas , Betacoronavirus , China , Infecções por Coronavirus/prevenção & controle , Equipamentos e Provisões/normas , Humanos , Medicina Nuclear/métodos , Pandemias/prevenção & controle , Segurança do Paciente/normas , Recursos Humanos em Hospital , Pneumonia Viral/prevenção & controle , Serviço Hospitalar de Radiologia/normas , Singapura , Estados Unidos
14.
Rev. habanera cienc. méd ; 19(1): 167-179, ene.-feb. 2020. tab, graf
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1099154

RESUMO

Introducción: El análisis de riesgo en la gestión de la calidad y seguridad permite la mejora continua de los servicios médicos en Cuba. En Medicina Nuclear Terapéutica es requisito regulador que permite la continuidad de estos servicios a la población. Objetivo: Analizar los riesgos radiológicos con enfoque integrador dirigido a causas básicas de fallo en la práctica citada. Material y métodos: Se revisó y adaptó el modelo genérico de riesgo para cada caso de estudio. Los métodos prospectivos de matriz de riesgo y análisis de modos y efectos de fallo y reactivo de aprendizaje de las lecciones de sucesos registrados fueron utilizados con el código cubano SECURE MR-FMEA versión 3.0. Se determinó el riesgo inherente, su tratamiento y el riesgo residual por práctica. Se identificaron las etapas del proceso, las medidas y las causas básicas más contribuyentes. Resultados: No se obtuvo riesgo superior al del nivel alto. La radiosinoviortesis y el tratamiento radiactivo de la policitemia vera tuvieron la mayor cantidad de modificaciones al modelo genérico. Las etapas más significativas son prescripción clínica, preparación del radiofármaco y administración. Las medidas preventivas de mayor importancia son mantener una carga de trabajo moderada para el personal, las capacitaciones de los médicos nucleares y del técnico que realiza la administración. Conclusiones: Existe una no uniformidad en el nivel de calidad y seguridad entre los servicios analizados. Para el cambio, la adopción de decisiones se ve beneficiada en su eficacia y eficiencia, al integrarse los métodos prospectivos y reactivos de análisis de riesgo(AU)


Introduction: Risk assessment in quality and safety management allows the continuous improvement of the medical services in Cuba. In Therapeutic Nuclear Medicine, it is a regulatory requirement which allows the continuity of these services to the population. Objective: To assess radiological risks with an integrated approach focused on underlying causes of failure in the mentioned practice. Material and Methods: The generic risk model was reviewed and adapted for each case study. The prospective methods of risk assessment matrix of failure modes and effects and incident learning lessons from the events registered were used applying the Cuban code SECURE MR-FMEA version 3.0. The inherent risk, treatment, and residual risk in the practice were determined. The stages of the process, measurements, and the main contributing causes were identified. Results: There was no risk higher than the high level. Radiosynoviorthesis and the radioactive treatment of the Polycythemia Vera had the greatest amount of modifications to the generic model. The most significant stages are clinical prescription, preparation of the radiopharmaceutical formulation and administration. The most important preventive measures are to maintain a moderate workload for the personnel, and the training of the nuclear physicians and the technician who performs the administration. Conclusions: There is a non-uniformity in the level of quality and safety among the NTM services in Cuba. For change, decision-making is benefited in terms of effectiveness and efficiency by integrating prospective and reactive risk assessment methods(AU)


Assuntos
Humanos , Masculino , Feminino , Qualidade da Assistência à Saúde/normas , Riscos de Radiação , Medicina Nuclear/métodos , Modelos de Riscos Proporcionais , Cuba
15.
Medicine (Baltimore) ; 98(48): e18207, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31770279

RESUMO

Few indexes are available for nuclear medicine image quality assessment, particularly for respiratory blur assessment. A variety of methods for the identification of blur parameters has been proposed in literature mostly for photographic pictures but these methods suffer from a high sensitivity to noise, making them unsuitable to evaluate nuclear medicine images. In this paper, we aim to calibrate and test a new blur index to assess image quality.Blur index calibration was evaluated by numerical simulation for various lesions size and intensity of uptake. Calibrated blur index was then tested on gamma-camera phantom acquisitions, PET phantom acquisitions and real-patient PET images and compared to human visual evaluation.For an optimal filter parameter of 9, non-weighted and weighted blur index led to an automated classification close to the human one in phantom experiments and identified each time the sharpest image in all the 40 datasets of 4 images. Weighted blur index was significantly correlated to human classification (ρ = 0.69 [0.45;0.84] P < .001) when used on patient PET acquisitions.The provided index allows to objectively characterize the respiratory blur in nuclear medicine acquisition, whether in planar or tomographic images and might be useful in respiratory gating applications.


Assuntos
Aumento da Imagem/métodos , Medicina Nuclear , Tomografia por Emissão de Pósitrons , Algoritmos , Humanos , Medicina Nuclear/métodos , Medicina Nuclear/normas , Tomografia por Emissão de Pósitrons/instrumentação , Tomografia por Emissão de Pósitrons/métodos , Tomografia por Emissão de Pósitrons/normas , Razão Sinal-Ruído
16.
Semin Nucl Med ; 49(5): 357-368, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31470931

RESUMO

Nuclear medicine techniques involving SPECT and PET are being increasingly used as a noninvasive tool for the detection, quantitation and therapy response monitoring of a myriad of disease processes through target visualization and kinetic modeling. The target selection requires a good understanding of the physiologic changes involved in the disease processes. The target selected can range from cellular proteins expressed in a particular organ, biochemical pathways in cells, or receptors on circulating blood cells. This can have a significant impact on therapeutic options for subsequent therapies, including radionuclide therapies in this evolving world of theranostic practices, which is outlined in this review.


Assuntos
Medicina Nuclear/métodos , Diagnóstico por Imagem , Humanos , Terapia de Alvo Molecular , Compostos Radiofarmacêuticos/metabolismo , Compostos Radiofarmacêuticos/uso terapêutico
17.
Semin Nucl Med ; 49(5): 411-421, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31470934

RESUMO

Management of a patient's blood glucose or metabolism in nuclear medicine studies has become an integral aspect of daily work primarily due to the increasing use of F-18 flurodeoxyglucose (FDG) positron emission tomography (PET). Newer tracers such as F-18 Fluciclovine and C-11 Choline, are in theory subject to metabolic shifts and changes based on patients' insulin levels, and also require attention to achieving optimum patient preparation. Metabolic derangements can also affect other studies, such as gastric emptying (GE), the results of which are dependent upon the patient's blood glucose level during the time of imaging. The growing variety of diabetic medications has increased the complexity of the instructions which need to be given to patients. Current guidelines for patient preparation were developed in the past and have only slowly evolved with the introduction of newer oral medications. In addition to older insulin formulations newer formulations with different profiles of onset, duration, and consistency of action are being used. The wide spectrum of newer drugs now in use for treating diabetes has not been accompanied by any updated consensus on how to manage these drugs for imaging studies which require blood glucose level management. In this article we review these newer diabetes medications primarily to raise awareness of the changing landscape. Our focus will be on suggestions to optimize patient preparation and management for these studies. For each scenario, our suggestions will be given as summary proposals for best patient management. Our hope is that this discussion will stimulate multicenter studies to provide data to support new practice guidelines for metabolically dependent nuclear medicine procedures.


Assuntos
Glicemia/metabolismo , Medicina Nuclear/métodos , Animais , Diabetes Mellitus/diagnóstico por imagem , Diabetes Mellitus/tratamento farmacológico , Diabetes Mellitus/metabolismo , Diabetes Mellitus/fisiopatologia , Esvaziamento Gástrico , Humanos , Insulina/uso terapêutico , Tomografia por Emissão de Pósitrons
18.
Semin Nucl Med ; 49(5): 422-437, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31470935

RESUMO

Precision oncology is being driven by rapid advances in novel diagnostics and therapeutic interventions, with treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations. Inherent in the theranostics paradigm is the assumption that diagnostic test results can precisely determine whether an individual is likely to benefit from a specific treatment. As part and integral in the current era of precision oncology, theranostics in the context of nuclear medicine aims to identify the appropriate molecular targets in neoplasms (diagnostic tool), so that the optimal ligands and radionuclides (therapeutic tool) with favorable labeling chemistry can be selected for personalized management of a specific disease, taking into consideration the specific patient, and subsequently monitor treatment response. Over the past two decades, the use of gallium-68 labeled peptides for somatostatin receptor (SSTR)-targeted PET/CT (or PET/MRI) imaging followed by lutetium-177 and yttrium-90 labeled SSTR-agonist for peptide receptor radionuclide therapy has demonstrated remarkable success in the management of neuroendocrine neoplasms, and paved the way to other indications of theranostics. Rapid advances are being made in the development of other peptide-based radiopharmaceuticals, small molecular-weight ligands and with newer radioisotopes with more favorable kinetics, potentially useful for theranostics strategies for the clinical application. The present review features the Bad Berka experience with first-in-human studies of new radiopharmaceuticals, for example, prostate-specific membrane antigen ligand, gastrin-releasing peptide receptor, neurotensin receptor 1 ligand, novel SSTR-targeting peptides and nonpeptide, and bone-seeking radiopharmaceuticals. Also new radioisotopes, for example, actinium (225Ac), copper (64Cu), scandium (44Sc), and terbium (152Tb/161Tb) will be discussed briefly demonstrating the development from basic science to precision oncology in the clinical setting.


Assuntos
Medicina Nuclear/métodos , Pesquisa Médica Translacional/métodos , Animais , Humanos , Peptídeos/química , Peptídeos/metabolismo , Peptídeos/uso terapêutico , Compostos Radiofarmacêuticos/uso terapêutico
19.
Semin Nucl Med ; 49(5): 438-449, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31470936

RESUMO

Radiomics - the high-throughput computation of quantitative image features extracted from medical imaging modalities- can be used to aid clinical decision support systems in order to build diagnostic, prognostic, and predictive models, which could ultimately improve personalized management based on individual characteristics. Various tools for radiomic features extraction are available, and the field gained a substantial scientific momentum for standardization and validation. Radiomics analysis of molecular imaging is expected to provide more comprehensive description of tissues than that of currently used parameters. We here review the workflow of radiomics, the challenges the field currently faces, and its potential for inclusion in clinical decision support systems to maximize disease characterization, and to improve clinical decision-making. We also present guidelines for standardization and implementation of radiomics in order to facilitate its transition to clinical use.


Assuntos
Sistemas de Apoio a Decisões Clínicas , Processamento de Imagem Assistida por Computador/métodos , Medicina Nuclear/métodos , Humanos , Processamento de Imagem Assistida por Computador/normas , Imagem Molecular , Medicina Nuclear/normas , Padrões de Referência
20.
Rev. argent. radiol ; 83(3): 102-112, set. 2019. ilus
Artigo em Espanhol | LILACS | ID: biblio-1057408

RESUMO

El intervencionismo en mama se inició con la localización preoperatoria de lesiones no palpables. En una segunda etapa, el desarrollo de técnicas de biopsias en las tres modalidades (mamografía, ultrasonido y resonancia magnética), reforzaron las indicaciones de localización de lesiones con histología ya confirmada. La técnica de localización en Argentina se basó casi exclusivamente en la inserción de alambres con arpones e inyección de carbón. A partir del año 2001, se ofreció como alternativa a las localizaciones con arpones la inserción de semilla de Iodo-125, considerando las ventajas para la paciente, el cirujano y el sistema hospitalario al desacoplar los turnos de quirófano y servicios de imágenes, otorgando acceso a cualquier cuadrante con incisiones cosméticas. La provisión del isótopo es la clave para instalar y atender la demanda de los usuarios, una vez que han conocido los méritos del procedimiento. En todos los ámbitos y distintos países, se verificó una lenta incorporación a la rutina de localización de lesiones con material radioactivo, primariamente por las regulaciones fundamentales y justificadas para la adquisición del isótopo. En nuestro medio y en una labor conjunta con la Autoridad Regulatoria Nuclear (ARN), logramos finalmente, en el año 2017, el reconocimiento de la práctica. Revisamos la bibliografía, describimos la técnica y la logística para lograr autorización de aquellos centros interesados en aplicar un procedimiento universalmente adoptado por sus ventajas respecto a los métodos tradicionales.


Diagnostic intervention in breast disease started with preoperative localization of non- palpable lesions. Later, with the histological diagnosis obtained through biopsy techniques in mammography, ultrasound and magnetic resonance imaging, the localization of lesions has become a must. Traditionally, in Argentina, the localization technique was exclusively based on the insertion of harpoon-shaped guided wires and carbon suspension. Since 2001, the iodine-125 radioactive seed localization has emerged as a reliable and advantageous alternative for the patient, the surgeon and the hospital system, reducing scheduling conflicts between the breast imaging department and the surgical department, and allowing access to any quadrant with cosmetic incisions. The isotope provision is the key to satisfying the users demand, once they have known the merits of the procedure. The implementation of radioactive material for the localization of lesions has been tardy in all fields and in different countries, mainly due to justified regulations related to the acquisition of the isotope. As a result of joint efforts with the Autoridad Regulatoria Nuclear (Nuclear Regulatory Authority), the practice finally gained its deserved recognition in 2017. We conducted a review of the existing literature and described the technique and the logistics to obtain the approval of the sites that were interested in the deployment of a widely used procedure that has proved to be more advantageous than traditional methods.


Assuntos
Humanos , Neoplasias da Mama/diagnóstico por imagem , Medicina Nuclear/métodos , Argentina , Neoplasias da Mama/cirurgia , Neoplasias da Mama/patologia
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