Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 130
Filtrar
1.
BMJ Case Rep ; 14(1)2021 Jan 27.
Artigo em Inglês | MEDLINE | ID: mdl-33504529

RESUMO

A 47-year-old woman was admitted to our clinic for intensive pain in the left flank region. The transvaginal ultrasound showed a left adnexal solid mass with ascites. She had undergone surgical removal of skin melanoma in 2008, but in September 2019, intracardiac metastasis resulting from it had been discovered. CT performed in March 2020 had been negative for other metastases. A full abdomen ultrasound was not performed. During the night, the patient began to show signs and symptoms of hypovolaemic shock. The patient was urgently transferred to the operating room for a video laparoscopy. A vast left retroperitoneal haematoma was diagnosed along with voluminous enlargement of the left ovary. We proceeded with a left adnexectomy and blood transfusion. Subsequent contrast-enhanced CT revealed a left subcapsular, perirenal haematoma and a voluminous retroperitoneal haematoma. Kidney metastasis was also seen. The final histological diagnosis was metastatic amelanotic malignant melanoma of the ovary.


Assuntos
Hemorragia/diagnóstico por imagem , Nefropatias/diagnóstico por imagem , Neoplasias Renais/secundário , Melanoma Amelanótico/secundário , Melanoma/secundário , Neoplasias Ovarianas/secundário , Neoplasias Cutâneas/patologia , Transfusão de Sangue , Feminino , Hemorragia/etiologia , Humanos , Nefropatias/etiologia , Neoplasias Renais/complicações , Neoplasias Renais/diagnóstico por imagem , Melanoma/complicações , Melanoma/diagnóstico por imagem , Melanoma/cirurgia , Melanoma Amelanótico/complicações , Melanoma Amelanótico/diagnóstico por imagem , Melanoma Amelanótico/cirurgia , Pessoa de Meia-Idade , Neoplasias Ovarianas/diagnóstico por imagem , Neoplasias Ovarianas/cirurgia , Espaço Retroperitoneal , Choque/etiologia , Tomografia Computadorizada por Raios X
4.
Arch Soc Esp Oftalmol ; 94(2): 81-84, 2019 Feb.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-30342820

RESUMO

We report an unusual case of an amelanotic melanoma in a 7 year old hispanic child with subclinical globe perforation. Uveal melanoma rarely occurs in children. Young affected patients are mostly light-colored eye Caucasian adolescents. Since they are not common, these tumors are usually not recognized and misdiagnosed. Differential diagnoses and therapeutic options are outlined.


Assuntos
Perfuração da Córnea/etiologia , Neoplasias da Íris/complicações , Melanoma Amelanótico/complicações , Criança , Diagnóstico Diferencial , Enucleação Ocular , Hemorragia Ocular/etiologia , Humanos , Neoplasias da Íris/diagnóstico , Neoplasias da Íris/patologia , Neoplasias da Íris/cirurgia , Masculino , Melanoma Amelanótico/diagnóstico , Melanoma Amelanótico/patologia , Melanoma Amelanótico/cirurgia
5.
World Neurosurg ; 122: 229-239, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30404049

RESUMO

BACKGROUND: Meningeal melanoma is a rare tumor of the central nervous system, whose amelanotic variant is called "amelanotic meningeal melanoma" (AMM). AMM does not produce melanin and therefore does not exhibit typical short T1 and short T2 signal on magnetic resonance imaging and thus can be easily misdiagnosed and be inappropriately managed. To date, only 4 AMM cases have been reported in the English literature. Here, we report the fifth case. CASE DESCRIPTION: A 26-year-old female patient presented with a 4-month history of progressive headache and nausea, the conventional magnetic resonance imaging demonstrated a posterior fossa mass accompanied by diffuse leptomeningeal dissemination. Repeated cerebrospinal fluid cytology screening showed negative results. The functional magnetic resonance examinations, including diffusion-weighted imaging, proton magnetic resonance spectroscopy, and dynamic susceptibility contrast perfusion-weighted imaging, provided complementary information. The final diagnosis of AMM was made by immunohistochemistry. Despite gross total excision of the tumor, the disease progressed, and the patient died 10 months after diagnosis. CONCLUSIONS: Our experience with this case demonstrated that meningeal melanoma should be included in the differential diagnosis when an intracranial mass is accompanied by leptomeningeal dissemination, and especially when proton magnetic resonance spectroscopy and dynamic susceptibility contrast perfusion-weighted imaging indicate a malignant tumor whereas diffusion-weighted imaging does not. And the loss of a typical melanin signal should not server as an excluding criterion for meningeal melanoma.


Assuntos
Melanoma Amelanótico/diagnóstico , Neoplasias Meníngeas/diagnóstico , Meninges/diagnóstico por imagem , Adulto , Diagnóstico Diferencial , Evolução Fatal , Feminino , Humanos , Melanoma Amelanótico/patologia , Melanoma Amelanótico/cirurgia , Neoplasias Meníngeas/patologia , Neoplasias Meníngeas/cirurgia , Meninges/patologia , Meninges/cirurgia , Metástase Neoplásica/diagnóstico por imagem
6.
Intern Med ; 58(7): 969-972, 2019 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-30449771

RESUMO

A 51-year-old man was diagnosed with stage IIC nodular malignant melanoma (T4bN0M0) of the right upper arm. The tumor was treatment-refractory, and left-sided pleural effusion emerged 1.5 years later. Aspiration of pleural fluid revealed abundant amelanotic, atypical cells that resembled epithelial malignant mesothelioma or lung adenocarcinoma cells; these cells were positive for melanoma-associated antigen recognized by T cells (MART-1)/Melan-A, HMB-45, and S-100 on immunocytochemistry. Thoracic computed tomography (CT) revealed marked diffuse pleural thickening in the left hemithorax that mimicked malignant mesothelioma; thus, the present report describes the unique cytological and radiological findings of this case.


Assuntos
Neoplasias Pulmonares/diagnóstico , Melanoma Amelanótico/diagnóstico , Mesotelioma/diagnóstico , Pleura/diagnóstico por imagem , Neoplasias Pleurais/diagnóstico , Biópsia , Diagnóstico Diferencial , Humanos , Masculino , Melanoma Amelanótico/cirurgia , Pessoa de Meia-Idade , Neoplasias Pleurais/cirurgia , Tomografia Computadorizada por Raios X
8.
BMJ Case Rep ; 20182018 Mar 29.
Artigo em Inglês | MEDLINE | ID: mdl-29602781

RESUMO

Amelanotic melanoma (AM) is a rare form of melanoma which lacks visible pigment. Due to the achromic manifestation of this atypical cutaneous malignancy, it has been difficult to establish clinical criteria for diagnosis. Thus, AM often progresses into an invasive disease due to delayed diagnosis. In this report, we describe the case of a 72-year-old Caucasian woman who had been diagnosed with AM after 3 years of failed treatments for what presented as a periorbital dermatitis. Her Clark's level 4, 1.30 mm thick melanoma required nine surgeries for successful resection and reconstruction. This case exemplifies the diagnostic pitfall of AM and the need for new criteria for early detection and management.


Assuntos
Melanoma Amelanótico/patologia , Melanoma Amelanótico/cirurgia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgia , Idoso , Biópsia , Diagnóstico Diferencial , Sobrancelhas , Pálpebras/cirurgia , Feminino , Humanos , Melanoma Amelanótico/diagnóstico , Procedimentos Cirúrgicos Reconstrutivos , Neoplasias Cutâneas/diagnóstico
9.
J Neurol Surg A Cent Eur Neurosurg ; 79(1): 96-100, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28750450

RESUMO

Primary malignant melanomas of the central nervous system (CNS) are rarely seen entities in the clinical routine. Primary amelanotic melanomas are even rarer. In our literature review, we found only six case reports of primary amelanotic CNS melanomas. Our case report describes the course of a 71-year-old man with a primary amelanotic CNS melanoma with secondary spread to the spine.


Assuntos
Neoplasias Cerebelares/patologia , Melanoma Amelanótico/secundário , Neoplasias da Coluna Vertebral/secundário , Idoso , Neoplasias Cerebelares/diagnóstico por imagem , Neoplasias Cerebelares/cirurgia , Humanos , Imagem por Ressonância Magnética , Masculino , Melanoma Amelanótico/diagnóstico por imagem , Melanoma Amelanótico/cirurgia , Neoplasias da Coluna Vertebral/diagnóstico por imagem , Neoplasias da Coluna Vertebral/cirurgia
10.
Dermatol Ther ; 31(1)2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-28976625

RESUMO

Disseminated superficial actinic porokeratosis (DSAP) is the most common variant of porokeratosis with a potential for malignant transformation. Its association with malignant melanoma, however, is exceedingly rare. Treatment of DSAP is often ineffective. We report a unique case of amelanotic melanoma arising within a lesion of DSAP. The melanoma was managed surgically, and her DSAP were treated successfully with a novel approach utilizing 5-fluorouracil chemowraps.


Assuntos
Antimetabólitos Antineoplásicos/administração & dosagem , Transformação Celular Neoplásica , Fluoruracila/administração & dosagem , Melanoma Amelanótico/cirurgia , Poroceratose/tratamento farmacológico , Lesões Pré-Cancerosas/tratamento farmacológico , Neoplasias Cutâneas/cirurgia , Administração Cutânea , Idoso , Bandagens , Biópsia , Transformação Celular Neoplásica/patologia , Feminino , Humanos , Melanoma Amelanótico/patologia , Poroceratose/diagnóstico , Lesões Pré-Cancerosas/diagnóstico , Neoplasias Cutâneas/patologia , Resultado do Tratamento
11.
J Cutan Med Surg ; 22(1): 51-57, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-28685596

RESUMO

Amelanotic lentigo maligna melanoma represents <2% of melanomas. Diagnosis is delayed owing to the lack of lesion pigmentation and advanced disease at presentation. Excision with appropriate margins is the treatment standard, but the starting point for such margins is often unclear. We describe 2 patients with amelanotic melanoma treated by Mohs micrographic surgery (MMS) that would not have been cleared by wide local excision alone and provide an extensive review of the literature. Both patients presented with histologic diagnoses of malignant melanoma, one with a barely perceptible biopsy site scar on the left infraorbital cheek/lower eyelid (Breslow 1.8 mm) and the second with an amelanotic tumour on the right helix (Breslow 10 mm). Due to location, aggressive histology, amelanotic appearance, and no apparent surrounding skin surface changes, MMS was elected to maximise margin control. For patient 1, invasive and in situ tumour was found at the American Joint Committee on Cancer-recommended margin of 1.5 cm, and the final defect measured 8.5 × 4.8 cm. Patient 2 had a significant invasive and amelanotic lentigo maligna component, resulting in a 9.0 × 6.5-cm defect. MMS allows for immediate histologic feedback on tumour margins of a clinically invisible tumour and thus offers the most definitive treatment.


Assuntos
Melanoma Amelanótico/cirurgia , Cirurgia de Mohs , Neoplasias Cutâneas/cirurgia , Idoso de 80 Anos ou mais , Face/patologia , Face/cirurgia , Humanos , Masculino , Melanoma Amelanótico/patologia , Neoplasias Cutâneas/patologia
14.
J Drugs Dermatol ; 16(11): 1164-1165, 2017 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-29141067

RESUMO

Amelanotic melanoma (AM) is one of the great masqueraders in dermatology. It is a very difficult clinical diagnosis to make because these tumors are devoid of pigment and other clues of melanoma. They are commonly misdiagnosed clinically as other benign and malignant conditions. We present a new case of AM in an 84-year-old woman with a history of non-melanoma skin cancer. She had a thin pink plaque that was initially misdiagnosed as a basal cell carcinoma. We also discuss dermoscopy and its valuable role to improve diagnostic accuracy. A review of dermoscopic features that favor and oppose the clinical diagnosis of AM is discussed. Even with dermoscopy, it is still important to have a high index of suspicion and a low threshold to biopsy when the clinical diagnosis is unclear.

J Drugs Dermatol. 2017;16(11):1164-1165.

.


Assuntos
Melanoma Amelanótico/diagnóstico , Neoplasias Cutâneas/diagnóstico , Idoso de 80 Anos ou mais , Dermoscopia , Diagnóstico Diferencial , Feminino , Humanos , Melanoma Amelanótico/cirurgia , Neoplasias Cutâneas/cirurgia
15.
Ann R Coll Surg Engl ; 99(5): e131-e134, 2017 May.
Artigo em Inglês | MEDLINE | ID: mdl-28462646

RESUMO

Primary malignant melanoma of the gastrointestinal tract is extremely rare. A 35-year-old man presented with complaints of abdominal pain and weight loss. Contrast enhanced computed tomography showed a large mass involving the duodenum and the superior mesenteric vessels. Upper gastrointestinal endoscopy demonstrated a large, friable mass along the duodenal wall and biopsy was suggestive of malignant melanoma. A detailed physical examination and whole body imaging (positron emission tomography and computed tomography) did not reveal any other lesion. The patient underwent a pancreaticoduodenectomy with segmental resection and anastomosis of the superior mesenteric vein as well as a segmental colectomy. His postoperative recovery was uneventful. The histopathology of the operative specimen showed a malignant amelanotic melanoma arising from the duodenum with lymph nodal involvement. He received oral temozolomide. However, he developed liver metastasis at six months and again at ten months, which was managed with radiofrequency ablation both times. He is doing well at 32 months of follow-up review. Multimodality treatment including surgery, adjuvant chemotherapy and salvage therapy appears to be a promising tool for achieving long-term survival in such patients.


Assuntos
Neoplasias Duodenais , Melanoma Amelanótico , Adulto , Ablação por Cateter , Neoplasias Duodenais/diagnóstico por imagem , Neoplasias Duodenais/patologia , Neoplasias Duodenais/cirurgia , Humanos , Masculino , Melanoma Amelanótico/diagnóstico por imagem , Melanoma Amelanótico/patologia , Melanoma Amelanótico/cirurgia , Pancreaticoduodenectomia
17.
J Vet Diagn Invest ; 29(4): 544-547, 2017 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-28423984

RESUMO

A large, pedunculated cutaneous mass protruding from the left flank fold and an enlarged left prefemoral lymph node were found on examination of a 3-d-old crossbred Aberdeen Angus heifer. The calf was asymptomatic aside from peripheral lymphadenopathy, and the mass, along with the left prefemoral lymph node, was surgically excised. Histologic examination of the mass and the lymph node revealed a homogeneous population of neoplastic cells that stained positively with immunohistochemical stains S100 and melan A, supporting a diagnosis of congenital amelanotic melanoma with nodal metastasis. Two months later, the calf became acutely recumbent and was euthanized after clinical examination revealed widespread metastasis. Gross autopsy revealed widely disseminated metastases that involved vertebral bodies, spinal cord, heart, kidneys, lungs, oral mucosa, multiple lymph nodes, and the marrow cavity of several long bones. Our case serves as a reminder that, although rare, congenital neoplasms occur in bovids and have the potential for aggressive, metastatic behavior.


Assuntos
Doenças dos Bovinos/cirurgia , Melanoma Amelanótico/veterinária , Neoplasias Cutâneas/veterinária , Animais , Bovinos , Doenças dos Bovinos/congênito , Diagnóstico Diferencial , Evolução Fatal , Feminino , Linfonodos/cirurgia , Melanoma Amelanótico/congênito , Melanoma Amelanótico/cirurgia , Neoplasias Cutâneas/congênito , Neoplasias Cutâneas/cirurgia
19.
Clin Exp Dermatol ; 42(1): 84-88, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27910137

RESUMO

Melanoma in individuals with oculocutaneous albinism has been reported in the literature to be rare compared with the more common occurrence of squamous cell carcinoma and basal cell carcinoma. We present a singular case of amelanotic naevoid melanoma arising from a small congenital naevus in a 16-month old albino boy, the youngest reported to date.


Assuntos
Albinismo Oculocutâneo/complicações , Melanoma Amelanótico/complicações , Nevo/complicações , Pele/patologia , Albinismo Oculocutâneo/diagnóstico , Procedimentos Cirúrgicos Dermatológicos/métodos , Humanos , Lactente , Masculino , Melanoma Amelanótico/diagnóstico , Melanoma Amelanótico/cirurgia , Nevo/congênito , Nevo/cirurgia
20.
J Coll Physicians Surg Pak ; 26(9): 781-3, 2016 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-27671185

RESUMO

A 60-year Brazilian woman, presented with an enlarged lymph node in the neck for one year, and a superficial nonulcerated lesion was observed in the scalp. Fine needle aspiration and biopsy of the lymph node revealed amelanocytic metastasis, and immunohistochemistry study showed Melan-A/ Mart-1 antigen (clone A103 and S-100 protein). The entire suspected area of the scalp was further resected and an amelanotic melanoma without angiolymphatic invasion was diagnosed. Ultrasonography and PET-computed tomography showed hypermetabolic cystic area in the right parotid. Furthermore, aspiration biopsy and surgical samples from parotid cyst confirmed the malignant amelanotic melanoma. Cystic metastases are scarcely reported in parotid gland, and can pose diagnostic challenges.


Assuntos
Metástase Linfática/diagnóstico , Melanoma Amelanótico/secundário , Glândula Parótida/diagnóstico por imagem , Neoplasias Parotídeas/secundário , Couro Cabeludo/patologia , Neoplasias Cutâneas/secundário , Antígenos de Neoplasias/análise , Biópsia por Agulha Fina , Feminino , Humanos , Imuno-Histoquímica , Linfonodos/patologia , Metástase Linfática/patologia , Antígeno MART-1 , Melanoma Amelanótico/patologia , Melanoma Amelanótico/cirurgia , Pessoa de Meia-Idade , Proteínas de Neoplasias/análise , Glândula Parótida/patologia , Neoplasias Parotídeas/cirurgia , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Proteínas S100/análise , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgia , Resultado do Tratamento , Ultrassonografia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA