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1.
Acta Derm Venereol ; 103: adv00841, 2023 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-36600530

RESUMO

Basal cell carcinoma is the most prevalent cancer in Caucasians worldwide. The aim of this study was to examine the overall risk of melanoma among patients diagnosed with basal cell carcinoma. This population-based retrospective cohort study included data from January 2010 to December 2018 from the databases of the Clalit Health Maintenance Organization and 2 major pathology laboratories in North District, Israel. The incidence and hazard ratio of melanoma in patients with a diagnosis of basal cell carcinoma were determined. Of 466,700 participants, 51% were women and the mean (standard deviation) follow-up was 6.7 (2.9; range 1-9) years. A total of 3,338 patients were diagnosed with basal cell carcinoma during the study period, 82 of whom subsequently developed melanoma. Patients with basal cell carcinoma had a significantly higher incidence of melanoma than patients without basal cell carcinoma (2.46% vs 0.37%; p < 0.0001). Univariate Cox regression analysis revealed a hazard ratio of 6.6 (95% confidence interval: 3.6-12.1; p < 0.0001) for melanoma in patients with a diagnosis of basal cell carcinoma. In conclusion, a diagnosis of basal cell carcinoma confers a significant risk of melanoma.


Assuntos
Carcinoma Basocelular , Melanoma , Neoplasias Cutâneas , Humanos , Feminino , Masculino , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/patologia , Estudos Retrospectivos , Estudos de Coortes , Carcinoma Basocelular/epidemiologia , Carcinoma Basocelular/patologia , Melanoma/epidemiologia , Melanoma/patologia , Incidência , Fatores de Risco
3.
Dermatologie (Heidelb) ; 74(2): 108-113, 2023 Feb.
Artigo em Alemão | MEDLINE | ID: mdl-36645432

RESUMO

BACKGROUND: Measures used to contain the spread of coronavirus disease 2019 (COVID-19) have impaired the social participation of many people. Especially people with chronic or oncologic conditions were affected. In this observational study, we aimed to assess social participation in melanoma patients with immune checkpoint therapy. Therefore, we investigated social participation in a very specific group and consider this a basis for further studies in a growing collective of long-term survivors in an era of infectious diseases. MATERIALS AND METHODS: Cross-sectional assessment via the index to measure social participation and health associated quality of life ("Index zur Messung von Einschränkungen der Teilhabe", IMET). Results are compared with published norm data. RESULTS: In all, 47 melanoma patients (mean age 58.5 years, standard deviation 13.2) were included: 18 patients had advanced melanoma stage III and received adjuvant Immunotherapy, while 29 patients were treated because of metastatic melanoma (stage IV). Results of the IMET showed no significant impairments in social participation when regarding the total score and when being compared to prepandemic norm data. Female patients did have significantly impaired participation. CONCLUSION: The endpoints health-related quality of life and social participation are important in long-term survivors with melanoma. During the pandemic, women of our collective were especially at risk for impairment of social participation. Differences between pandemic and disease-specific influences on social participation cannot be derived from our data. Nevertheless, this study will be part of growing and necessary research on long-term cancer survivors diseases.


Assuntos
COVID-19 , Melanoma , Humanos , Feminino , Pessoa de Meia-Idade , COVID-19/epidemiologia , Pandemias , Participação Social , Qualidade de Vida , Estudos Transversais , Melanoma/epidemiologia
5.
Eur J Cancer Prev ; 31(4): 377-384, 2022 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-34545023

RESUMO

BACKGROUND: The incidence of cutaneous melanoma has risen faster than almost any other type of cancer in the last 50 years. Ultraviolet (UV) radiation and genetic susceptibility are the most important risk factors. OBJECTIVE: We aimed to determine the epidemiologic indicators of melanoma in Hungary, a country with an estimated population of 9.8 million and an area of 93 030 km2. METHODS: Anonymized patient records from the National Health Insurance Fund Management covering the entire population were used to determine the incidence and prevalence of melanoma in the counties of Hungary from 2013 to 2017. Altogether 20 030 melanoma cases were identified for inclusion in this study. RESULTS: The prevalence of melanoma increased over the investigated period and was significantly higher among women than men. The incidence of melanoma stagnated during this period and the incidence rate was the highest among the elderly. Interestingly, the incidence was higher in males in the elderly population, while the incidence was higher in females in the younger (<60 years) population. Geographical variations in ambient UV radiation did not show statistically significant correlation with the regional variability of epidemiologic indicators, probably due to small differences in the number of bright sunshine hours per year between regions. Although Hungary is a relatively small country, we observed regional heterogeneity in socioeconomic factors. Notably, a significant and strong negative correlation was found between single-person household rates and melanoma prevalence. CONCLUSION: In addition to ambient UV radiation, melanoma incidence and prevalence appear to be related to age, gender and socioeconomic factors.


Assuntos
Melanoma , Neoplasias Cutâneas , Idoso , Feminino , Humanos , Hungria/epidemiologia , Incidência , Masculino , Melanoma/epidemiologia , Melanoma/etiologia , Melanoma/prevenção & controle , Prevalência , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/etiologia , Neoplasias Cutâneas/prevenção & controle , Fatores Socioeconômicos , Raios Ultravioleta/efeitos adversos
6.
Eur J Dermatol ; 32(5): 615-617, 2022 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-36468738

RESUMO

Background: The COVID-19 pandemic has influenced health care services all around the globe, which is also reflected in the diagnosis and management of malignant melanoma (MM). Objectives: We performed a retrospective assessment of the impact of the COVID-19 pandemic on the diagnosis of MM in order to evaluate the effects of the pandemic on MM care. Materials & Methods: The Breslow thickness of excised MM and total number of patients with newly diagnosed MM who underwent surgery during the first year of the pandemic (March, 2020 to February, 2021; 227 subjects) were compared relative to a control period the year before (March, 2019 to February, 2020; 201 subjects), based on a retrospective study design. Results: There was no significant decrease in the total number of excisions (227 subjects in the pre-COVID cohort vs. 201 in the COVID cohort). However, the mean Breslow thickness increased significantly from 1.1±1.4 mm in the pre-COVID group to 1.8±2.3 mm in the COVID group. Conclusion: We conclude that, due to several restrictions in the early phase of the pandemic, melanomas were diagnosed at a more advanced stage.


Assuntos
COVID-19 , Melanoma , Humanos , Estudos Retrospectivos , Pandemias , Melanoma/diagnóstico , Melanoma/epidemiologia , Melanoma/cirurgia
7.
J Drugs Dermatol ; 21(12): 1289-1293, 2022 Dec 01.
Artigo em Inglês | MEDLINE | ID: mdl-36468958

RESUMO

Melanoma is a tumor that continues to increase in both the number of cases presenting and mortality. Patients with disease that has spread beyond the cutaneous boundary still suffer from significant morbidity and mortality despite advances in immune therapy. It is incumbent that clinicians keep up with the latest advances in both tumorigenesis and metastatic capabilities, and be aware of clinical, histopathologic, and genetic metrics to assist in the early diagnosis of aggressive tumors. This review synopsizes some of the most recent findings. J Drugs Dermatol. 2022;21(12):1289-1293. doi:10.36849/JDD.6814.


Assuntos
Melanoma , Neoplasias Cutâneas , Humanos , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/genética , Melanoma/diagnóstico , Melanoma/epidemiologia , Melanoma/genética , Carcinogênese/genética
8.
Environ Health ; 21(1): 126, 2022 12 09.
Artigo em Inglês | MEDLINE | ID: mdl-36482443

RESUMO

Per- and polyfluoroalkyl substances (PFAS) are endocrine disrupting chemicals which could be associated with cancer development, such as kidney and testicular cancers, pancreatic and hepatocellular carcinoma and thyroid tumor. Available scientific literature offers no information on the role of PFAS in melanoma development/progression. Since 1965, a massive environmental contamination by PFAS has occurred in northeastern Italy. This study compared histopathology and prognosis between melanoma patients exposed (n = 194) and unexposed (n = 488) to PFAS. All patients were diagnosed and/or treated for melanoma at the Veneto Oncological Institute and the University Hospital of Padua (Italy) in 1998-2014. Patients were categorized in exposed or unexposed groups according to their home address and the geographical classification of municipalities affected by PFAS contamination as provided by Veneto Government in 2018. Presence of mitoses was found in 70.5% of exposed patients and 58.7% of unexposed patients (p = 0.005). Median follow-up was 90 months (IQR 59-136). 5-year overall survival was 83.7% in exposed patients and 88.0% in unexposed patients (p = 0.20); 5-year disease-specific survival was 88.0% in exposed patients and 90.9% in unexposed patients (p = 0.50); 5-year disease-free survival was 83.8% in exposed patients and 87.3% in unexposed patients (p = 0.20). Adjusting for imbalanced characteristics at baseline (presence of mitoses), survival was not statistically different between exposed and unexposed patients (overall survival: HR 1.10, 95% CI 0.77 to 1.58, p = 0.57; disease-specific survival: HR 0.99, 95% CI 0.62 to 1.59, p = 0.99; disease-free survival: HR 1.10, 95% CI 0.74 to 1.64, p = 0.62). Although the magnitude of PFAS exposure was not quantifiable, our findings suggested that exposure to PFAS was associated with higher level of mitosis in melanoma patients, but this did not translate into a survival difference. Further studies are required to investigate this relationship and all effects of PFAS on prognosis.


Assuntos
Melanoma , Humanos , Estudos Retrospectivos , Melanoma/epidemiologia , Itália/epidemiologia
9.
Actas dermo-sifiliogr. (Ed. impr.) ; 113(10): 961-965, nov.- dic. 2022. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-213044

RESUMO

Las consultas monográficas de dermatoscopia digital están dirigidas a la población con alto riesgo de melanoma. Conocer los motivos de derivación a estas consultas, así como las características epidemiológicas de los pacientes permite optimizar los recursos sanitarios, y determinar qué pacientes se benefician más de esta técnica. Se analizaron los motivos de derivación y las características epidemiológicas de 413 pacientes atendidos en una consulta monográfica de dermatoscopia en un período de 10 años, y que presentaban al menos un criterio de alto riesgo de melanoma. También se analizó el número necesario de extirpaciones (NNE) por cada melanoma diagnosticado, sus características histológicas y las variables no ambientales se asociaron con su diagnóstico. Los motivos de derivación más frecuentes fueron: antecedentes de melanoma previo (21,5%), cambios detectados por el paciente o su familia (20%), hallazgos clínicos y/o dermatoscópicos sospechosos de malignidad (19,4%) y antecedentes familiares de melanoma (17,4%). Setenta y seis de las 178 lesiones extirpadas fueron melanomas, obteniendo un NNE de 2,34. La edad avanzada fue el único factor de riesgo que se asoció de forma estadísticamente significativa con el desarrollo de melanoma (AU)


Dedicated dermoscopy units assess individuals at high risk for melanoma. Understanding the reasons for referral to these units and the epidemiological profile of referred patients can help optimize health care resources and determine who benefits most from dermoscopic evaluation. We analyzed reasons for referral and epidemiological characteristics of 413 patients with at least 1 high-risk factor for melanoma seen at a dedicated dermoscopy unit over a period of 10 years. We also analyzed the number of necessary excisions (NNE) for each melanoma diagnosed, histologic features, and associations between nonenvironmental factors and diagnosis. The main reasons for referral were a past history of melanoma (21.5%), changes detected by the patient or a relative (20%), clinical and/or dermoscopic findings suggestive of malignancy (19.4%), and a family history of melanoma (17.4%). Seventy-six of the 178 excised lesions were melanomas (NNE per melanoma detected, 2.34). Older age was the only risk factor significantly associated with the development of melanoma (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Encaminhamento e Consulta/estatística & dados numéricos , Melanoma/epidemiologia , Nevo Pigmentado/epidemiologia , Neoplasias Cutâneas/epidemiologia , Seguimentos , Estudos Retrospectivos , Espanha/epidemiologia , Incidência , Dermoscopia , Melanoma/diagnóstico , Nevo Pigmentado/diagnóstico , Neoplasias Cutâneas/diagnóstico
10.
Actas dermo-sifiliogr. (Ed. impr.) ; 113(10): t961-t965, nov.- dic. 2022. tab, graf
Artigo em Inglês | IBECS | ID: ibc-213045

RESUMO

Dedicated dermoscopy units assess individuals at high risk for melanoma. Understanding the reasons for referral to these units and the epidemiological profile of referred patients can help optimize health care resources and determine who benefits most from dermoscopic evaluation. We analyzed reasons for referral and epidemiological characteristics of 413 patients with at least 1 high-risk factor for melanoma seen at a dedicated dermoscopy unit over a period of 10 years. We also analyzed the number of necessary excisions (NNE) for each melanoma diagnosed, histologic features, and associations between nonenvironmental factors and diagnosis. The main reasons for referral were a past history of melanoma (21.5%), changes detected by the patient or a relative (20%), clinical and/or dermoscopic findings suggestive of malignancy (19.4%), and a family history of melanoma (17.4%). Seventy-six of the 178 excised lesions were melanomas (NNE per melanoma detected, 2.34). Older age was the only risk factor significantly associated with the development of melanoma (AU)


Las consultas monográficas de dermatoscopia digital están dirigidas a la población con alto riesgo de melanoma. Conocer los motivos de derivación a estas consultas, así como las características epidemiológicas de los pacientes permite optimizar los recursos sanitarios, y determinar qué pacientes se benefician más de esta técnica. Se analizaron los motivos de derivación y las características epidemiológicas de 413 pacientes atendidos en una consulta monográfica de dermatoscopia en un período de 10 años, y que presentaban al menos un criterio de alto riesgo de melanoma. También se analizó el número necesario de extirpaciones (NNE) por cada melanoma diagnosticado, sus características histológicas y las variables no ambientales se asociaron con su diagnóstico. Los motivos de derivación más frecuentes fueron: antecedentes de melanoma previo (21,5%), cambios detectados por el paciente o su familia (20%), hallazgos clínicos y/o dermatoscópicos sospechosos de malignidad (19,4%) y antecedentes familiares de melanoma (17,4%). Setenta y seis de las 178 lesiones extirpadas fueron melanomas, obteniendo un NNE de 2,34. La edad avanzada fue el único factor de riesgo que se asoció de forma estadísticamente significativa con el desarrollo de melanoma (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Encaminhamento e Consulta/estatística & dados numéricos , Melanoma/epidemiologia , Nevo Pigmentado/epidemiologia , Neoplasias Cutâneas/epidemiologia , Seguimentos , Estudos Retrospectivos , Espanha/epidemiologia , Incidência , Dermoscopia , Melanoma/diagnóstico , Nevo Pigmentado/diagnóstico , Neoplasias Cutâneas/diagnóstico
11.
Curr Oncol ; 29(12): 9671-9680, 2022 12 08.
Artigo em Inglês | MEDLINE | ID: mdl-36547173

RESUMO

Over five million cases of skin cancer are diagnosed each year in the United States with melanoma the third most common cancer in young adults. While publications have shown that sunburns increase the risk of developing melanoma throughout the lifetime including in adolescence and adulthood showing the importance of altering sun exposing behaviors throughout the lifetime, use of sun protection in college students remails low. In Fall 2019, an online survey of undergraduate students living on campus at a large southwestern university was conducted to determine the frequency of recent sunburns as well as sun protective behaviors and perceived knowledge of and barriers to sun protection. Associations between knowledge, behaviors, and barriers with self-reported sunburn were evaluated using logistic regression. Over 46% of 458 students reported at least one sunburn in the past three months and 21% reported having multiple sunburns in that period. Furthermore, 53% reported that they intentionally tanned their skin outdoors occasionally or more frequently, while 6.4% reported using an indoor tanning bed occasionally or more. Adjusted for skin sensitivity, recent sunburn history was associated with higher tanning activity scores and with high agreement that tanning was attractive (p < 0.01). This information can inform a more targeted series of intervention programming on the university campus.


Assuntos
Melanoma , Queimadura Solar , Adolescente , Adulto Jovem , Humanos , Estados Unidos , Adulto , Queimadura Solar/prevenção & controle , Queimadura Solar/tratamento farmacológico , Raios Ultravioleta/efeitos adversos , Protetores Solares/uso terapêutico , Melanoma/epidemiologia , Melanoma/prevenção & controle , Melanoma/tratamento farmacológico , Estudantes
12.
Artigo em Inglês | MEDLINE | ID: mdl-36554683

RESUMO

Early melanoma diagnosis plays a key role in ensuring best prognosis with good survival rates. The ongoing global COVID-19 pandemic has greatly impacted global and national healthcare systems, thus making it a real challenge. The aim of this study was to evaluate the impact of the pandemic on diagnostic delay in melanoma patients in Serbia. In this retrospective study, we included patients treated at the university hospital in Serbia's capitol over a period of five years and three months. We compared the prepandemic (01/JAN/17-14/MAR/20) and pandemic periods (15/MAR/20-31/MAR/22) by evaluating patient demographic data, melanoma subtype, Breslow thickness, Clark level, ulceration status, mitotic index rate and pT staging. We observed a significant reduction in the number of diagnosed patients (86.3 vs. 13.7%; p = 0.036), with melanomas having an increased median Breslow thickness (1.80 vs. 3.00; p = 0.010), a higher percentage of Clark IV-V level lesions (44.0% vs. 63.0%; p = 0.009), an increase in median mitotic index rate (2 vs. 5; p < 0.001) and a trend of increase in lesions thicker than 2 mm (37.8% vs. 53.7%; p = 0.026). We believe that this study can be a useful scenario guide for future similar events, highlighting the importance of preventive measures and timely diagnosis for the best patient outcomes.


Assuntos
COVID-19 , Melanoma , Neoplasias Cutâneas , Humanos , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/epidemiologia , Pandemias , Estudos Retrospectivos , Diagnóstico Tardio , Estadiamento de Neoplasias , COVID-19/diagnóstico , COVID-19/epidemiologia , Melanoma/diagnóstico , Melanoma/epidemiologia
13.
Artigo em Inglês | MEDLINE | ID: mdl-36498192

RESUMO

The aim of this article is to assess mortality trends due to skin melanoma in Poland between the years 2000 and 2020, taking into account gender and place of residence (urban, rural). The subject of the analyses was data on 25,061 deaths that occurred between 2000 and 2020 due to skin melanoma (C43 according to ICD-10). Mortality rates due to this cancer, both crude (CDR) and standardised (SDR), were calculated. Trends on the calculated rates were analysed using the annual percentage change (APC) and average annual percentage change (AAPC), obtained from joinpoint regression models. Over the study period, the standardised death rate (SDR) due to skin melanoma in Poland increased from 3.60 to 4.03 per 100,000 population (AAPC = 1.1; p < 0.05), for urban residents it increased from 3.56 to 3.91 (APC = 1.2; p < 0.05) and for rural residents it increased from 3.00 to 4.24 (APC = 2.2; p < 0.05). A higher growth rate in terms of the SDR value between the years 2000 and 2020 was recorded in men compared to women and in rural when compared to urban residents. In Poland, mortality due to skin melanoma is on the rise. The early diagnosis of this cancer should become common practice in the Polish population.


Assuntos
Melanoma , População Rural , Masculino , Humanos , Feminino , Polônia/epidemiologia , Classificação Internacional de Doenças , Registros , Melanoma/epidemiologia , Mortalidade
14.
Cutis ; 110(3): 150-154, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36446115

RESUMO

Mutations of the BRAF oncogene occur in both melanomas and several other cancers. Our objective was to determine if mutant BRAF V600E expression in a population-based cohort of patients with melanoma was associated with the development of a second primary malignancy of any type. Using the resources of the Rochester Epidemiology Project, we retrospectively identified 380 patients aged 18 to 60 years who were diagnosed with an incident melanoma from 1970 through 2009. We reviewed individual medical records to identify second primary malignancies. We evaluated mutant BRAF V600E expression from available melanoma tissue specimens and assessed its association with the development of a second primary malignancy. BRAF V600E expression in melanomas is associated with an increased risk for basal cell carcinoma (BCC).


Assuntos
Carcinoma Basocelular , Melanoma , Segunda Neoplasia Primária , Neoplasias Cutâneas , Humanos , Segunda Neoplasia Primária/epidemiologia , Segunda Neoplasia Primária/genética , Proteínas Proto-Oncogênicas B-raf/genética , Estudos Retrospectivos , Melanoma/epidemiologia , Melanoma/genética , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/genética
15.
Cutis ; 110(3): 132-136, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36446116

RESUMO

Occupational sun exposure is a well-known risk factor for the development of melanoma and nonmelanoma skin cancer (NMSC), especially among US military personnel who may have inadequate access to sun protection, are located in geographic regions with increased sun exposure, and work with potential carcinogens. Herein, we describe a case of a military service member who developed skin cancer at an early age potentially due to occupational sun exposure. We also provide a review of the literature to examine the risk factors and incidence of melanoma and NMSC in US military personnel and veterans, as well as provide recommendations for skin cancer prevention, screening, and intervention in the military population.


Assuntos
Melanoma , Militares , Exposição Ocupacional , Neoplasias Cutâneas , Veteranos , Humanos , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/epidemiologia , Melanoma/diagnóstico , Melanoma/epidemiologia , Exposição Ocupacional/efeitos adversos
16.
Rev Assoc Med Bras (1992) ; 68(10): 1405-1409, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36417644

RESUMO

OBJECTIVE: Malignant cutaneous melanoma is the most aggressive type of skin cancer, and its early detection and prompt initiation of treatment play an important role in reducing disease-associated morbidity and mortality. Many factors influence the diagnosis of melanoma, and its recognition is essential for the development of strategies for its early detection. This study was carried out to Identify the main variables related to the delay in diagnosis of Malignant Cutaneous Melanoma and correlate them with the time interval for making the definitive diagnosis. METHODS: Retrospective analysis of 103 patient records from January 2015 to December 2020 correlating social, economic, demographic, and cultural factors with the time elapsed between the onset of symptoms and the diagnosis of malignant cutaneous melanoma. RESULTS: The average time to seek medical services from the onset of symptoms was 29.54 months. The mean time for a referral from the primary to the referral service was 1.35 months, and the factors that contributed to a faster diagnosis were lesion Breslow (>1 mm), lesion growth, income range (≤1.5 minimum wages), lower phototypes (I and II), not having gone to the Basic Healthcare Units, profession (household), smoking, and type of housing. CONCLUSIONS: Our findings demonstrate that there is still a great delay in the recognition of signs and symptoms related to the diagnosis of malignant cutaneous melanoma in our country, influenced by several socioeconomic and demographic factors.


Assuntos
Melanoma , Neoplasias Cutâneas , Humanos , Melanoma/diagnóstico , Melanoma/epidemiologia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/patologia , Estudos Retrospectivos , Diagnóstico Tardio , Fatores de Tempo , Fatores Socioeconômicos , Demografia
17.
BMC Cancer ; 22(1): 1207, 2022 Nov 23.
Artigo em Inglês | MEDLINE | ID: mdl-36419046

RESUMO

BACKGROUND: In recent years, benchmarking and assessment methods to improve the quality of care have become increasingly important. Such approaches allow for a uniform assessment, comparisons between centers or over time, and the identification of weaknesses. In this study, the results of a 20-month pilot program to assess, monitor and improve the quality of care in melanoma patients primarily treated surgically are presented. METHODS: The pilot program started in May 2020 at the Lower Silesian Oncology, Pulmonology and Hematology Center (LSOPHC) in Wroclaw, Poland (Lower Silesian Voivodeship, southwestern province of Poland with a population of 2,9 million). The program involved the introduction of a synoptic histopathological protocol, medical coordinators, and a set of measures to assess oncological care. In total, 11 Skin Cancer Unit (SCU) measures were introduced to analyze clinical outcomes, diagnostic quality, and duration. Data from 352 patients covered by the program were analyzed. In addition, the completeness of diagnostics from external sites was compared to our own results. Furthermore, the timeliness of the initial diagnostic tests and in-depth diagnostics were assessed and compared to the timeliness before implementation of the pilot program. RESULTS: The introduced measures assessed the mortality related to oncological treatment, the rate of complications, advanced stages of melanoma, the completeness and duration of diagnostics, the involved nodes after lymphadenectomy, and melanoma screening. During the study period, the timeliness of the initial diagnostics was maintained at 87.8%, and the timeliness of the in-depth diagnostics at 89.5%. Compared to a similar period before the program, these values were 36.1% and 67.5%, respectively. CONCLUSION: The introduced measures seem to be effective and practical tools for benchmarking clinical and diagnostic aspects. They also allowed for a sensitive assessment of individual issues and indicated sensitive points. Furthermore, the actions undertaken in this pilot program allowed for a shortening of the duration of diagnostics.


Assuntos
Melanoma , Neoplasias Cutâneas , Humanos , Polônia/epidemiologia , Projetos Piloto , Melanoma/diagnóstico , Melanoma/epidemiologia , Melanoma/terapia , Oncologia , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/terapia
18.
J Drugs Dermatol ; 21(11): 1235-1241, 2022 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-36342731

RESUMO

BACKGROUND: The United States Preventative Task Force (USPTF) has concluded that the benefit of skin cancer screenings is inconclusive. A systematic review found that implementing skin cancer screening increased detection of in situ and thin melanoma, increased incidence of non-melanoma skin cancer detection, and decreased rates of thick melanoma. However, only one of the studies reviewed found a reduction in melanoma mortality. Evidence is notably unclear for the exact benefits of preventative skin cancer screening. OBJECTIVE: This study intends to discover the current skin cancer screening practices and recommendations of dermatologists. METHODS: A 20-question “Skin Cancer Screening Survey” was developed and sent to the American College of Mohs Surgery. RESULTS: 124 dermatologists completed the survey. The majority of physicians (77.4%) said they perform routine skin cancer screening exams. 37.9 % of respondents noted that they recommend routine skin cancer screenings to all their patients, while 27.4 % of participants recommend screening only patients with a risk factor. Most of the respondents (52.4%) stated that they do not follow any specific guidelines regarding routine skin cancer screenings. The majority selected that they usually perform full body skin exams (69.4%). Of those who answered that they do follow guidelines, most followed the American Academy of Dermatology guidelines (48.5%). 42.7% of respondents were aware of the USPTF recommendations regarding routine skin cancer screening. DISCUSSION: The results demonstrate variability in real world practice of skin cancer screening exams. There is imperative need for evidence-based uniform guidelines to drive accurate and unbiased preventative practice behaviors in the United States. J Drugs Dermatol. 2022;21(11):1235-1241. doi:10.36849/JDD.6660.


Assuntos
Dermatologia , Melanoma , Neoplasias Cutâneas , Humanos , Estados Unidos/epidemiologia , Dermatologistas , Dermatologia/métodos , Detecção Precoce de Câncer , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/prevenção & controle , Melanoma/diagnóstico , Melanoma/epidemiologia , Melanoma/prevenção & controle , Inquéritos e Questionários
19.
Curr Oncol ; 29(11): 8374-8389, 2022 Nov 02.
Artigo em Inglês | MEDLINE | ID: mdl-36354720

RESUMO

BACKGROUND: Large epidemiological studies describing the trends in incidence rates and mortality of synchronous brain metastases (SBMs) are lacking. The study aimed to provide a comprehensive understanding of the changes in the incidence and mortality of SBMs over the previous ten years. METHODS: Trends in the incidence of solid malignancies outside of the CNS in patients with SBMs and incidence-based mortality rates were assessed using data from the Surveillance, Epidemiology, and End Results database. Joinpoint analyses were used to calculate annual percent changes (APCs) and 95% CIs. RESULTS: Between 2010 and 2019, 66,655 patients, including 34,821 (52.24%) men and 31,834 (47.76%) women, were found to have SBMs, and 57,692 deaths occurred over this period. Lung cancer SBMs, melanoma SBMs, and breast cancer SBMs were ranked in the top three, having the highest age-standardized incidence rates. The incidence of SBMs decreased significantly with an APC of -0.6% from 2010 to 2019, while the APC was 1.2% for lung cancer SBMs, 2.5% for melanoma SBMs, and 0.6% for breast cancer SBMs. The SBM mortality first experienced a rapid increase (APC = 28.6%) from 2010 to 2012 and then showed a significant decline at an APC of -1.8% from 2012 to 2019. Lung cancer SBMs showed similar trends, while melanoma SBM and breast cancer SBM mortality increased continuously. CONCLUSIONS: SBMs incidence (2010-2019) and incidence-based mortality (2012-2019) declined significantly. These findings can advance our understanding of the prevalence of SBMs.


Assuntos
Neoplasias Encefálicas , Neoplasias da Mama , Neoplasias Pulmonares , Melanoma , Masculino , Estados Unidos/epidemiologia , Humanos , Feminino , Incidência , Neoplasias Encefálicas/epidemiologia , Neoplasias Pulmonares/epidemiologia , Melanoma/epidemiologia
20.
Curr Oncol ; 29(11): 8886-8903, 2022 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-36421352

RESUMO

Indoor tanning (sunbeds, solarium) uses artificial ultraviolet radiation (UVR) to stimulate cosmetic tanning of the skin. Indoor tanning has been officially classified as a human carcinogen in 2009 by the International Agency for Research on Cancer of the World Health Organization (WHO). The differences in the prevalence of sunbed use across countries and over the years highlight underlying legislative, climatic, and cultural differences. Indoor tanning-seeking behaviors may be driven by motivations for an appealing appearance, largely influenced by gender and age, and several misconceptions that a prevacation tan safeguards the skin, that sunbeds can be used to treat acne or to increase vitamin D, or that tanning is a healthy habit. This review provides an epidemiological update on the prevalence of sunbed use, who tends to use sunbeds and why, and details the current evidence on the association of sunbeds with skin cancers, including cutaneous melanoma, basal cell carcinoma (BCC), and cutaneous squamous cell carcinoma (cSCC). A statistically significant higher risk of cutaneous melanoma, BCC and cSCC with the use of sunbeds has been consistently demonstrated. This risk of skin cancer is even higher with the more frequent use of sunbeds, underscoring a dose-response relationship, and in those first exposed to sunbeds at a younger age. Preventive measures against sunbed use include legislation restricting sunbed use, educational campaigns to inform and discourage from indoor tanning, as well as using the internet, online advertising messages and the social media to reach larger audiences and to promote an untanned appearance.


Assuntos
Carcinoma de Células Escamosas , Melanoma , Neoplasias Cutâneas , Humanos , Melanoma/epidemiologia , Melanoma/etiologia , Neoplasias Cutâneas/epidemiologia , Neoplasias Cutâneas/etiologia , Raios Ultravioleta/efeitos adversos
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