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1.
BMJ Case Rep ; 14(1)2021 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-33431461

RESUMO

Peritoneal melanosis is an uncommon benign condition, the pathophysiology of which is unclear. Macroscopically, it appears as diffuse dark brown or black pigmentation within the peritoneum, mimicking more sinister conditions such as metastatic melanoma. It has been described in a variety of contexts, but only exceedingly rarely in association with metastatic melanoma, with only two previous published case reports. We present a case of peritoneal melanosis associated with metastatic melanoma involving the spleen, previously treated with targeted and immune checkpoint inhibitor therapy. With increasing reports of melanoma regression manifesting as cutaneous tumorous melanosis in patients treated with immune checkpoint inhibitors, we postulate that, similarly, immunotherapy and tumour regression might have a role to play in the pathogenesis of the peritoneal pigmentation in this case.


Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Melanoma/terapia , Melanose/diagnóstico , Doenças Peritoneais/diagnóstico , Neoplasias Cutâneas/terapia , Neoplasias Esplênicas/cirurgia , Biópsia , Quimioterapia Adjuvante , Humanos , Masculino , Melanoma/complicações , Melanoma/imunologia , Melanoma/secundário , Melanose/induzido quimicamente , Melanose/imunologia , Melanose/patologia , Pessoa de Meia-Idade , Doenças Peritoneais/induzido quimicamente , Doenças Peritoneais/imunologia , Doenças Peritoneais/patologia , Peritônio/efeitos dos fármacos , Peritônio/imunologia , Peritônio/patologia , Tomografia por Emissão de Pósitrons , Inibidores de Proteínas Quinases/efeitos adversos , Neoplasias Cutâneas/complicações , Neoplasias Cutâneas/imunologia , Neoplasias Cutâneas/patologia , Baço/diagnóstico por imagem , Baço/patologia , Baço/cirurgia , Esplenectomia , Neoplasias Esplênicas/diagnóstico , Neoplasias Esplênicas/secundário
3.
Turk Neurosurg ; 30(4): 476-482, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32672341

RESUMO

AIM: To analyze the current literature on neurocutaneous melanosis (NCM), as well as, our cases, in order to better define the prognosis and the presence of risk factors affecting it, thus, offering better information to the parents. MATERIAL AND METHODS: Two cases observed at the Pediatric Neurosurgery Unit of the Catholic University Medical School in Rome are described. Both of them had cutaneous stigmata and cerebral MR evidence of intracranial melanin deposits. These two children showed a very different clinical course. RESULTS: The present study enlighten the differences among the two cases and review the literature on the subject, with the attempt to understand which are clinical and disease related factors that might influence the prognosis. CONCLUSION: Beside malignant features of cutaneous melanotic lesions, the presence of hydrocephalus at diagnosis and the early appearance of clinical symptoms, when appearing contemporarily, are predicting the rapid progression of the disease and a worse prognosis.


Assuntos
Melanose/patologia , Síndromes Neurocutâneas/patologia , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Melanose/mortalidade , Síndromes Neurocutâneas/mortalidade , Prognóstico
5.
Int J Mol Sci ; 21(5)2020 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-32121626

RESUMO

Riehl's melanosis is a hyperpigmentary disorder that occurs predominantly on the face and neck. To date, the pathogenesis of Riehl's melanosis with regards to the melanogenic properties and paracrine melanogenic molecules has not well been studied. This study was aimed to provide a novel perspective on the pathogenesis of Riehl's melanosis by identifying the relevant paracrine melanogenic molecules in Riehl's melanosis. Skin biopsies were performed on lesional and normal-appearing perilesional skin of 12 patients with Riehl's melanosis and 12 age- and sex-matched healthy controls. Histopathological and immunohistochemical staining for paracrine melanogenic molecules was analyzed. The major histopathological findings of Riehl's melanosis were basal hyperpigmentation, melanocyte proliferation, interface change, dermal pigmentary incontinence, vascular proliferation, and dermal inflammation. Dermal expression intensities of stem cell factor (SCF) and c-kit were increased in the lesional skin of Riehl's melanosis. In addition, increased expression of epidermal and dermal ET-1 was also observed in the lesional skin of Riehl's melanosis. Increased tissue expressions of SCF, c-kit, and ET-1 in Riehl's melanosis support the role of these paracrine melanogenic molecules in the pathogenesis of Riehl's melanosis. The findings from this study might present useful information on the pathogenetic mechanism of Riehl's melanosis.


Assuntos
Perfilação da Expressão Gênica , Regulação da Expressão Gênica , Melaninas/metabolismo , Melanose/genética , Comunicação Parácrina , Antígenos CD/metabolismo , Antígenos de Diferenciação Mielomonocítica/metabolismo , Estudos de Casos e Controles , Endotelina-1/metabolismo , Fator XIIIa/metabolismo , Feminino , Humanos , Melanócitos/metabolismo , Melanócitos/patologia , Melanose/patologia , Pessoa de Meia-Idade , Proteínas Proto-Oncogênicas c-kit/metabolismo , Pele/patologia , Fator de Células-Tronco/metabolismo
6.
An Bras Dermatol ; 95(2): 217-220, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32173139

RESUMO

Melanonychia is the change in the coloration of the nail plate resulting from the deposition of melanin. Among its causes are melanocytic hyperplasia, melanocytic activation and nail melanoma. Subungual follicular inclusions are histological findings of unknown etiology, possibly related to trauma. We present three cases of melanonychia of different etiologies with subungual follicular inclusions, an association that has not been well described and with an indefinite pathogenesis.


Assuntos
Folículo Piloso/patologia , Melanose/patologia , Doenças da Unha/patologia , Adulto , Dermoscopia , Folículo Piloso/diagnóstico por imagem , Humanos , Masculino , Melanose/diagnóstico por imagem , Pessoa de Meia-Idade , Doenças da Unha/diagnóstico por imagem , Unhas/patologia , Ultrassonografia
7.
Am J Dermatopathol ; 42(2): 117-121, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31990700

RESUMO

Histological features of Riehl melanosis have rarely been compared between lesional and perilesional normal skin and have not been precisely described using quantitative or immunohistochemical analysis or electron microscopic findings. To investigate the histopathological and immunohistochemical features of lesional and perilesional normal skin of patients with Riehl melanosis, we retrospectively evaluated the electronic medical records and skin biopsy specimens of 48 patients with Riehl melanosis. In addition, electron microscopy was performed on 1 case. Fontana-Masson staining for melanin and immunohistochemical staining for Melan-A, NKI/beteb, tyrosinase, and microphthalmia-associated transcription factor were performed. Although the difference was statistically insignificant, melanin pigment was increased in the epidermis of lesional skin compared with that of perilesional normal skin in patients. The number of melanocytes and their activity were significantly increased in lesional epidermal skin. Melanin pigment was also significantly increased in the lesional dermis. Pigmentary incontinence, basal cell liquefaction, dilated vessels, epidermal spongiosis, and colloid bodies were found in the lesional skin as well as in the perilesional normal skin to a lesser extent. Under electron microscopy of 1 randomly selected subject, many fibrocytes contained numerous melanosome particles in the cytoplasm of the lesional dermis. In perilesional normal skin, fibroblasts also contained melanosome particles; however, the number of melanosome-containing cells was less than that in lesional skin. Riehl melanosis is characterized by increased epidermal melanocytes and pigmentation, primarily involving the dermis, with histologically typical changes at the interface. Unlike that in other pigmentary diseases, most perilesional normal-appearing skin in Riehl melanosis also shows typical histopathological changes, although to a lesser extent.


Assuntos
Melanose/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Epiderme/patologia , Feminino , Humanos , Masculino , Melanócitos/patologia , Pessoa de Meia-Idade , Estudos Retrospectivos
8.
Int J Colorectal Dis ; 35(2): 213-222, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31823053

RESUMO

BACKGROUND: Melanosis coli (MC) is a colonoscopic finding in which the colonic mucosa appears darkly pigmented than usual and generally caused by extended anthranoid laxative use. METHODS: We performed a retrospective study at Zhuhai Hospital to investigate the risk of MC for CR neoplasm development. A total of 12,776 patients who underwent colonoscopy from 2013 to 2016 including 250 diagnosed with MC and 500 controls were included in this study. Odds ratios (OR) and 95% confidence intervals (95%CI) for associations of MC with CR neoplasm detection were estimated using univariate and multivariable multinomial logistic analyses for known risk factors. RESULTS: The presence of MC was associated with a significant increase in the CR neoplasm detection rate compared with controls (OR = 1.701, 95% CI = 1.252-2.31; P = 0.001). The effect was also observed in different tumor sites, age group, gender, and lifestyle. Using univariate multinomial analysis, patients with MC were significantly associated with both hyperplastic polyp (OR = 2.069, 95% CI = 1.253-3.415; P = 0.005) and low-grade (LG) adenoma (OR = 1.585, 95% CI = 1.115-2.254; P = 0.010). However, there was no significant difference with adenocarcinoma (OR = 1.701, 95% CI = 0.990-2.924; P = 0.055). Using multivariate multinomial analysis, MC patients remained associated with increased hyperplastic polyp (OR = 1.870, 95% CI = 1.119-3.125; P = 0.017) and LG adenoma (OR = 1.474, 95% CI = 1.027-2.114; P = 0.035), but not adenocarcinoma (OR = 1.620, 95% CI = 0.914-2.871; P = 0.098). A significant increase in CR neoplasm rate was observed with drinker, smoker, and elderly patients but not with gender. CONCLUSION: Patients with MC were more likely to have both hyperplastic polyp and LG adenoma. If confirmed, such findings could suggest the discontinuation of anthranoid laxative use particularly in the elderly.


Assuntos
Pólipos Adenomatosos/epidemiologia , Colo/patologia , Doenças do Colo/epidemiologia , Pólipos do Colo/epidemiologia , Colonoscopia , Neoplasias Colorretais/epidemiologia , Mucosa Intestinal/patologia , Melanose/epidemiologia , Pólipos Adenomatosos/patologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , China/epidemiologia , Colo/química , Doenças do Colo/patologia , Pólipos do Colo/patologia , Neoplasias Colorretais/patologia , Feminino , Humanos , Mucosa Intestinal/química , Masculino , Melaninas/análise , Melanose/patologia , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Prevalência , Prognóstico , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Fatores de Tempo , Adulto Jovem
9.
Arch Dermatol Res ; 312(3): 223-227, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31531731

RESUMO

The pathogenesis of melasma is not fully understood, and the role of skin basement membrane zone (BMZ) alterations in disease development and the maintenance of hypermelanogenesis are also poorly known. We performed a comparative study to characterize the ultrastructural alterations that occur in BMZ in melasma and adjacent normal skin, as well as we discuss the implications of these changes in the physiopathology of the disease. Pairs of facial skin biopsies (2 mm) from 10 women with melasma and normal skin (< 2 cm apart) were processed by Transmission Electronic Microscopy or immunohistochemistry for Melan-A counterstained with Periodic acid-Schiff stain. Cytoplasmic organelles (from keratinocyte or melanocyte), BMZ damage were assessed and melanocyte counting (total and pendulous) was done. There was greater amount of cytoplasmic organelles inside basal keratinocytes and melanocytes in melasma, as well as structural damaged areas in the lamina densa (disruptions, gaps, lower density and thinning) and anchoring fibrils (lamina lucida), compared to healthy adjacent skin. Areas with pendulous melanocytes are characterized by discontinuity of BMZ ultrastructure. The prominence of cytoplasmic organelles from melanocytes and keratinocytes evidences the involvement of both cell groups in melasma. The damage in the lamina densa and lamina lucida suggest the role of upper dermis injury/repair process in the pathogenesis of the disease.


Assuntos
Membrana Basal/ultraestrutura , Face/patologia , Queratinócitos/patologia , Melanócitos/patologia , Melanose/patologia , Melanossomas/patologia , Pele/ultraestrutura , Humanos , Imuno-Histoquímica , Microscopia Eletrônica de Transmissão
10.
J Dermatolog Treat ; 31(1): 77-83, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30702958

RESUMO

Background: Treatment of melasma is challenging because its pathogenesis is unclear and it is prone to recurrence. We performed a meta-analysis to evaluate the efficacy and safety of laser and laser compound therapy for melasma.Methods: We searched the Cochrane, Embase, and Medline databases for all relevant studies published from inception to July 2018. All randomized controlled trials of melasma describing treatment with lasers or laser compound therapy were included.Results: A total of 346 patients were enrolled in nine RCT studies. Laser therapy and laser compound therapy had better PGA (MD: 1.96 (95% CI: 0.17, 3.75); I2 = 0%) and mMASI scores (MD: -1.57 (95% CI: -3.08, -0.05); I2 = 19%) than drug and laser therapy, respectively. Four studies were assessed to be of low risk of bias. Subgroup analysis was consistent with the results of the meta-analysis, reflecting the reliability of our results.Linking evidence to action: The results of this meta-analysis provide evidence that laser and laser compound therapy can improve the area and severity of melasma. Further high-quality clinical studies should be carried out in the future to confirm this conclusion. Abbreviations: MASI: Melasma Area and Severity Index; mMASI: modified Melasma Area and Severity Index; PGA: patient global assessment; MI: melasma index.


Assuntos
Terapia a Laser , Melanose/radioterapia , Bases de Dados Factuais , Humanos , Terapia a Laser/efeitos adversos , Terapia com Luz de Baixa Intensidade , Melanose/patologia , Recidiva , Índice de Gravidade de Doença
11.
BMJ Case Rep ; 12(10)2019 Oct 30.
Artigo em Inglês | MEDLINE | ID: mdl-31666252

RESUMO

A 1-day-old child was brought to the clinic for evaluation of enlarged right eye (OD). On examination, OD showed buphthalmos with diffuse scleral melanocytosis, fleshy blackish-brown extrascleral mass with corneal extension, and secondary glaucoma. Anterior segment evaluation revealed darkly pigmented iris and fundus evaluation OD revealed a darkly pigmented choroidal lesion. The left eye was within normal limits. A clinical diagnosis of choroidal melanocytoma with ocular melanocytosis was made. Enucleation OD followed by orbital implant was performed. Histopathology showed features of diffuse ocular melanocytosis involving limbus, iris, ciliary body, choroid, sclera, optic nerve head, optic nerve sheath, along with choroidal melanocytoma with extrascleral tumour extension. We presume that choroidal melanocytoma may have arisen from ocular melanocytosis.


Assuntos
Neoplasias da Coroide/congênito , Hidroftalmia/diagnóstico , Melanoma/patologia , Melanose/complicações , Neoplasias da Coroide/diagnóstico por imagem , Neoplasias da Coroide/patologia , Neoplasias da Coroide/cirurgia , Diagnóstico Diferencial , Enucleação Ocular/métodos , Neoplasias Oculares/diagnóstico por imagem , Neoplasias Oculares/patologia , Fundo de Olho , Humanos , Hidroftalmia/etiologia , Lactente , Masculino , Melanose/patologia , Doenças da Esclera/patologia , Resultado do Tratamento
12.
Dermatol Online J ; 25(10)2019 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-31735001

RESUMO

Melasma is an acquired hyperpigmentation disorder most commonly affecting females with darker skin types. It is triggered by several factors including sun exposure, genetic influences, and female sex hormones. The pathology of melasma extends beyond melanocytes and recent literature points to interactions between keratinocytes, mast cells, gene regulation abnormalities, neovascularization, and disruption of basement membrane. This complex pathogenesis makes melasma difficult to target and likely to recur post treatment. A better understanding of the latest pathological findings is key to developing novel and successful treatment options. This review aims to provide a summary of the more novel pathological findings and latest investigational therapies.


Assuntos
Fármacos Dermatológicos/uso terapêutico , Melanose , Administração Cutânea , Face/patologia , Feminino , Humanos , Queratinócitos/fisiologia , Mastócitos/fisiologia , Melanócitos/patologia , Melanose/etiologia , Melanose/patologia , Melanose/fisiopatologia , Melanose/terapia , Pele/patologia , Pele/fisiopatologia , Luz Solar/efeitos adversos , Protetores Solares/uso terapêutico
13.
Indian J Ophthalmol ; 67(12): 2092-2094, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31755472

RESUMO

We report a case of trifocal choroidal melanoma (three separate tumors) in a 48-year-old Caucasian female who had been followed for oculodermal melanocytosis since childhood. At presentation, no tumor was present and annual examination was advised. Seventeen years later, three choroidal melanocytic lesions were detected in the right eye. Growth of each was documented, enucleation was performed, and histopathology revealed three independent choroidal melanomas. The patient developed extensive liver and bone metastases and subsequently died. Oculodermal melanocytosis is a risk factor for the development of uveal melanoma and a potential marker for worse prognosis. Careful long-term follow-up is required.


Assuntos
Neoplasias da Coroide/diagnóstico , Melanócitos/patologia , Melanoma/diagnóstico , Melanose/patologia , Neoplasias Primárias Múltiplas/diagnóstico , Dermatopatias/patologia , Doenças da Úvea/patologia , Evolução Fatal , Feminino , Humanos , Pessoa de Meia-Idade , Doenças da Esclera/patologia
14.
Indian J Ophthalmol ; 67(12): 2089-2091, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31755471

RESUMO

A 51-year-old Asian Indian male with right oculodermal melanocytosis presented with a blurred visual acuity of 20/40. Upon fundus examination, he was discovered to have two independent pigmented choroidal melanomas in the temporal juxtapapillary region and inferiorly, in the region of trace clinical sectoral choroidal melanocytosis. The patient underwent enucleation, and on histopathology the two tumors were found to be in the area of choroidal melanocytosis, in continuity with each other. Multifocal choroidal melanoma is an exceedingly rare diagnosis. Ocular melanocytosis is a known predisposing factor for both unifocal and multifocal melanomas. Lifelong monitoring for uveal melanomas must be done in all patients with ocular melanocytosis.


Assuntos
Doenças da Coroide/patologia , Neoplasias da Coroide/diagnóstico , Melanócitos/patologia , Melanoma/diagnóstico , Melanose/patologia , Doenças da Esclera/patologia , Dermatopatias/patologia , Neoplasias da Coroide/cirurgia , Enucleação Ocular , Humanos , Masculino , Melanoma/cirurgia , Pessoa de Meia-Idade , Implantes Orbitários , Procedimentos Cirúrgicos Reconstrutivos , Acuidade Visual
15.
Indian J Ophthalmol ; 67(12): 2094-2097, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31755473

RESUMO

We present a rare case of a bilateral diffuse uveal melanocytic proliferation (BDUMP), which occurred secondary to recurrence of carcinoma of thyroid in a 79-year-old gentleman who was initially misdiagnosed to have age related macular degeneration and/or chronic central serous chorioretinopathy. In spite of being treated with anti-VEGF injection and photodynamic therapy there was progressive loss of vision. Multimodal imaging like autoflourescence, infrared imaging, fluorescein angiography, indocyanine angiography, and OCT angiography helped us in clinching the final diagnosis.


Assuntos
Melanócitos/patologia , Melanose/patologia , Síndromes Paraneoplásicas Oculares/diagnóstico , Neoplasias da Glândula Tireoide/patologia , Doenças da Úvea/diagnóstico , Idoso , Proliferação de Células , Evolução Fatal , Humanos , Masculino
17.
BMJ Case Rep ; 12(8)2019 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-31473636

RESUMO

Diffuse melanosis cutis (DMC) is an extremely rare and late complication of metastatic melanoma (MM). It involves the progressive blue-grey discolouration of the skin and mucous membranes, occurring approximately 1 year after diagnosis of MM. The pathogenesis of DMC is unknown, although specific growth factors, such as alpha-melanocyte stimulating hormone, hepatocyte growth factor and endothelin-1, released by cancer cells, along with release of melanin precursors in the bloodstream and dermal MM micrometastases producing melanin have been attributed. Even with appropriate therapy, DMC seems to be a poor prognostic factor, with a mean survival time of 4-5 months. Here, we report a case of BRAF-mutated MM who presented with DMC. The patient underwent BRAF/MEK inhibition followed by anti-PDL1 therapy, yet passed away approximately 1 year after diagnosis.


Assuntos
Melanoma/complicações , Melanose/etiologia , Neoplasias Cutâneas/complicações , Evolução Fatal , Feminino , Humanos , Melanoma/patologia , Melanose/patologia , Pessoa de Meia-Idade , Pele/patologia , Neoplasias Cutâneas/patologia
19.
Aust J Gen Pract ; 48(9): 621-624, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31476830

RESUMO

BACKGROUND: As a result of the rapidly changing hormonal milieu, changing or newly discovered pigmented skin lesions during pregnancy can be diagnostically challenging. It is important for GPs to be aware of the effect of gestational changes on pigment production and features that should raise concern. OBJECTIVE: The aim of this article is to provide an understanding of common changes that may occur in pigmented lesions during pregnancy, features that are of concern and the management of suspected melanoma in pregnant women. DISCUSSION: In pregnant women, changing naevi should be evaluated using conventional ABCDE melanoma diagnostic criteria, and suspicious lesions should not be attributed solely to a change in the hormonal milieu. In this population, diagnosed melanoma is probably best treated at a specialist centre.


Assuntos
Síndrome do Nevo Displásico/diagnóstico , Melanoma/diagnóstico , Melanose/diagnóstico , Nevo Pigmentado/diagnóstico , Complicações Neoplásicas na Gravidez/diagnóstico , Neoplasias Cutâneas/diagnóstico , Dermoscopia , Diagnóstico Diferencial , Síndrome do Nevo Displásico/patologia , Feminino , Medicina Geral , Humanos , Hiperpigmentação/diagnóstico , Melanoma/patologia , Melanose/patologia , Nevo/diagnóstico , Nevo/patologia , Nevo Pigmentado/patologia , Gravidez , Complicações na Gravidez/diagnóstico , Complicações na Gravidez/patologia , Complicações Neoplásicas na Gravidez/patologia , Encaminhamento e Consulta , Neoplasias Cutâneas/patologia
20.
Invest Ophthalmol Vis Sci ; 60(8): 2950-2957, 2019 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-31305861

RESUMO

Purpose: Chemokines play a role in the progression and metastatic spread of both cutaneous and uveal melanomas. The aim of this study was to examine the prognostic value of expression of chemokine receptors CCR7, CXCR4, and CCR10 in conjunctival melanocytic lesions. Methods: In total, 44 conjunctival nevi, 21 cases of primary acquired melanosis (PAM) with atypia and 35 conjunctival melanomas, were included. After immunohistochemical staining for CCR7, CXCR4, and CCR10 the immunoreactive score (IRS) was determined. The findings were correlated for association with melanoma and development of metastasis. For mechanistic evaluation, we used a mouse melanoma metastasis model using two human conjunctival melanoma cell lines, CM2005.1 and CRMM1. Results: All tested chemokines showed a significantly higher expression in conjunctival melanoma than conjunctival nevi. There was a statistically significant difference between the IRS in nevi and PAM with atypia for nuclear IRS in CCR10 (P = 0.03) and both nuclear and cytoplasmic IRS in CXCR4 (P < 0.01 and P = 0.03, respectively); this was also true evaluating the groups PAM with atypia and melanoma all together (P < 0.01). Furthermore, a trend for lower IRS was seen in cases of melanoma without metastasis, with a suggestive pattern of a higher IRS in cases that did develop metastases, supported for CXCR4 using the mouse melanoma metastasis model. Conclusions: Expression of specific chemokines changes during the progression and metastatic spread of conjunctival melanocytic lesions. Differential chemokine profiles may hold prognostic value for patients with conjunctival melanomas and might be considered as a therapeutic target.


Assuntos
Biomarcadores Tumorais/metabolismo , Doenças da Túnica Conjuntiva/metabolismo , Neoplasias da Túnica Conjuntiva/metabolismo , Receptores CCR10/metabolismo , Receptores CCR7/metabolismo , Receptores CXCR4/metabolismo , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Linhagem Celular Tumoral , Criança , Doenças da Túnica Conjuntiva/patologia , Neoplasias da Túnica Conjuntiva/patologia , Feminino , Humanos , Imuno-Histoquímica , Masculino , Melanoma/metabolismo , Melanoma/patologia , Melanose/metabolismo , Melanose/patologia , Pessoa de Meia-Idade , Nevo Pigmentado/metabolismo , Nevo Pigmentado/patologia
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