Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 27.116
Filtrar
1.
Anticancer Res ; 40(1): 545-550, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31892610

RESUMO

BACKGROUND/AIM: Many studies have shown an antiproliferative, anti-inflammatory, anti-angiogenetic, and apoptosis-inducing effect of Vitamin D. A vitamin D deficiency has been associated with an increased risk for different types of cancer. This study examined vitamin D 25(OH)D levels in gynaecological cancers in comparison with benign gynaecological diseases. PATIENTS AND METHODS: Serum 25(OH)D levels in 688 gynaecological patients (488 with malignant, 200 with a benign gynaecological disease) were assayed between 2009 and 2015 using an electrochemiluminescence immunoassay. RESULTS: In total, the 25(OH)D levels in cancer patients were lower, but not significantly lower than those in cancer-free patients. Significant results were shown regarding seasonal effects for patients with breast-, endometrial and ovarian cancer. No significant effects occurred with regard to menopause status, nicotine, or grade in relation to 25(OH)D levels. CONCLUSION: 25(OH)D levels seem to influence gynaecological cancers.


Assuntos
Doenças dos Genitais Femininos/sangue , Vitamina D/análogos & derivados , Fatores Etários , Feminino , Humanos , Menopausa/sangue , Estações do Ano , Vitamina D/sangue
2.
Zhonghua Zhong Liu Za Zhi ; 41(12): 953-958, 2019 Dec 23.
Artigo em Chinês | MEDLINE | ID: mdl-31874555

RESUMO

Aromatase inhibitors (AIs) directly applies to postmenopausal breast cancer patients. Patients underwent bilateral ovariectomy or ≥60 years were acknowledged as postmenopausal.Alternatively, for <60 years breast cancer patients, sex hormone detection to evaluate menopause is recommended by National Comprehensive Cancer Network (NCCN) guideline, textbooks, and AIs clinical trials.However, series of clinical trial found that, a broad overlap region of follicle stimulating hormone and estradiol appeared between premenopausal and postmenopausal patients, which unable to determine the menopause even with sensitivity promotion of detection equipment or manners.We have abandon this detection in clinical treatment, and decision making was only according to the relapse risk and disease status. We recommend bilateral ovariectomy resection accompanied with AIs for breast cancer patients with high recurrence risk (e.g. T3-4 or LNM≥4) or patients with advanced metastatic disease.However, patients with low or moderate recurrence risk can be treated with tamoxifen.


Assuntos
Antineoplásicos/administração & dosagem , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/cirurgia , Tamoxifeno/uso terapêutico , Idoso , Idoso de 80 Anos ou mais , Antineoplásicos Hormonais/uso terapêutico , Inibidores da Aromatase/uso terapêutico , Neoplasias da Mama/patologia , Feminino , Humanos , Menopausa , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Ovariectomia , Tamoxifeno/administração & dosagem
3.
Adv Exp Med Biol ; 1192: 225-249, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31705497

RESUMO

Brain disorders and mental diseases, in particular, are common and considered as a top global health challenge for the twenty-first century. Interestingly, women suffer more frequently from mental disorders than men. Moreover, women may respond to psychotropic drugs differently than men, and, through their lifespan, they endure sex-orientated social stressors. In this chapter, we present how women may differ in the development and manifestation of mental health issues and how they differ from men in pharmacokinetics and pharmacodynamics. We discuss issues in clinical trials regarding women participation, issues in the use of psychotropic medications in pregnancy, and challenges that psychiatry faces as a result of the wider use of contraceptives, of childbearing at older age, and of menopause. Such issues, among others, demand further women-oriented psychiatric research that can improve the care for women during the course of their lives. Indeed, despite all these known sex differences, psychiatry for both men and women patients uses the same approach. Thereby, a modified paradigm for women's psychiatry, which takes into account all these differences, emerges as a necessity, and psychiatric research should take more vigorously into account sex differences.


Assuntos
Menopausa/psicologia , Transtornos Mentais , Psiquiatria , Saúde Reprodutiva , Serviços de Saúde da Mulher , Idoso , Feminino , Saúde Global , Humanos , Masculino , Serviços de Saúde Mental , Gravidez , Psicotrópicos/uso terapêutico , Saúde da Mulher
4.
Orv Hetil ; 160(41): 1617-1622, 2019 Oct.
Artigo em Húngaro | MEDLINE | ID: mdl-31587579

RESUMO

Introduction: Genitourinary syndrome of menopause (GSM) affects up to 40-57% of postmenopausal women. Intravaginal microablative fractional CO2 laser is a new proposal for the management of GSM, although the evidence of safety and efficacy of the procedure appears to be insufficient. Aim: The aim of the study was to assess the efficacy of fractional CO2 laser for the treatment of GSM at the Department of Obstetrics and Gynecology of the University of Debrecen. Method: Postmenopausal women with symptoms of GSM underwent three sessions of microablative fractional rejuvenation CO2 laser therapy at 4-6 weeks intervals. Vaginal health index (VHI) scores were completed before each treatment and at 6 weeks follow-up as an objective measurement and visual analog scale was used to assess subjective complaints. Statistical analysis included Student's paired two-sampling t-test for the measure of statistical significance using the standard cutoff for significance p<0.05. Results: 51 women participated (mean age 57.0 ± 9.9 y). Average VHI score was 14.0 ± 4.9 before treatment, 15.0 ± 4.7 after the first session, 18.2 ± 4.6 after the second treatment and 19.5 ± 4.9 at follow-up. The improvement of VHI score was statistically significant between all sessions. Average VAS score was 15.6 ± 14.1 before treatment, 9.0 ± 10.8 after the first session, 5.9 ± 9.2 after the second treatment and 3.4 ± 7.5 at follow-up. The improvement of VAS score was statistically also significant between all sessions. Conclusions: Our study suggests that the fractional CO2 laser is an effective and safe treatment of symptoms associated with GSM. Orv Hetil. 2019; 160(41): 1617-1622.


Assuntos
Dióxido de Carbono/uso terapêutico , Dispareunia/cirurgia , Doenças Urogenitais Femininas/cirurgia , Terapia a Laser , Lasers de Gás/uso terapêutico , Menopausa , Disfunções Sexuais Fisiológicas/cirurgia , Doenças Vaginais/cirurgia , Idoso , Dispareunia/etiologia , Feminino , Humanos , Pessoa de Meia-Idade , Disfunções Sexuais Fisiológicas/etiologia , Síndrome , Resultado do Tratamento
5.
Medicine (Baltimore) ; 98(40): e17183, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31577708

RESUMO

This study aimed to compare the quality of histological endometrial samples collected through Pipelle aspiration and hysteroscopic biopsies to assess the agreement between these 2 biopsies in the histological diagnosis of malignancy and to compare the costs of both biopsies.This was a cross-sectional study. Forty-five women were biopsied, first using Pipelle and immediately after using hysteroscopy. The material collected was sent for analysis, and hysteroscopy was considered the gold standard. The results were divided into the following 3 categories: normal (atrophic, proliferative, and secretory endometrium); polyps; and malignancies. We report the agreement between Pipelle and hysteroscopy in the diagnosis of malignancy and compare their costs.The study showed that while analyzing endometrial malignancies, Pipelle sampling had 100% sensitivity and specificity. In the detection of polyps, Pipelle sampling showed 26.1% sensitivity, 88.9% specificity, 75% positive predictive value, 48.5% negative predictive value, and 53.7% accuracy. Agreement with hysteroscopy in the diagnosis of malignancy was 100%. The Pipelle device costs 27 times less than hysteroscopic biopsy for health insurance companies. This cost is 13.7 times lower in the Brazilian Unified Health System.Endometrial biopsies using the Pipelle have a high accuracy for endometrial cancer and a low accuracy for polyps. We detected 100% agreement between the reports of Pipelle and hysteroscopy with regard to malignancy. Pipelle is the most cost-effective method of endometrial biopsy.


Assuntos
Biópsia por Agulha/métodos , Neoplasias do Endométrio/patologia , Endométrio/patologia , Histeroscopia/métodos , Adulto , Idoso , Biópsia por Agulha/economia , Biópsia por Agulha/normas , Brasil , Estudos Transversais , Feminino , Humanos , Histeroscopia/economia , Histeroscopia/normas , Menopausa/fisiologia , Pessoa de Meia-Idade , Pólipos , Sensibilidade e Especificidade
6.
Rev Prat ; 69(6): e203-e207, 2019 Jun.
Artigo em Francês | MEDLINE | ID: mdl-31626442
7.
8.
Rev Prat ; 69(4): 373-376, 2019 Apr.
Artigo em Francês | MEDLINE | ID: mdl-31626484

RESUMO

Cardiovascular diseases are the primary cause of death in women. Cardiovascular risk is specific and often underestimated in women. At equal age, women have more cardiovascular risk factors than men. Some of them such as smoking and diabetes are associated with greater increase of cardiovascular risk and poorer prognosis in women as compared to men. In addition, women have a specific hormonal risk linked to contraception, pregnancy and menopause. Prevention, screening and diagnosis are generally implemented both at later stages and less frequently than in men because of particularities in clinical presentation, and treatments are not optimal in women. All these specificities must be considered for an optimized evaluation of cardiovascular risk and an improvement of management in women.


Assuntos
Doenças Cardiovasculares , Diabetes Mellitus , Fatores Etários , Doenças Cardiovasculares/epidemiologia , Feminino , Humanos , Masculino , Menopausa , Gravidez , Fatores de Risco , Fatores Sexuais , Fatores Socioeconômicos
9.
JAMA ; 322(12): 1206-1207, 2019 09 24.
Artigo em Inglês | MEDLINE | ID: mdl-31550026
11.
RECIIS (Online) ; 13(3): 557-568, jul.-set. 2019. ilus
Artigo em Português | LILACS | ID: biblio-1016984

RESUMO

Considerado uma 'epidemia global' pela Organização Mundial de Saúde (OMS), o estresse figura como um dos principais transtornos contemporâneos. Neste artigo, examinamos as construções discursivas do estresse feminino, ou seja, aquele especificamente relacionado às mulheres. Para isso, realizamos uma análise discursiva da revista Veja de 2000 a 2018. Nosso intuito é observar como o semanário trata as consequências da chamada 'emancipação feminina' em termos de estresse, a partir de duas principais vertentes: (1) a relação entre estresse, hormônios e TPM; (2) o estresse como consequência da 'tripla jornada' (o acúmulo dos papéis de profissional, esposa e mãe). Concluímos que tais discursos sobre o estresse feminino colaboram para reassegurar que certas fontes de tensão, bem como a forma de lidar com elas, sejam moralmente e fisiologicamente concernentes às mulheres.


Considered as a 'global epidemic' by the World Health Organization (WHO), stress figures as one of the major contemporary disorders. In this article, we examine the discursive constructions on female stress, that is, when the term is specifically related to women. In order to do so, we conduct a discursive analysis of the brazilian Veja magazine from 2000 to 2018. Our intention is to observe the ways in which the magazine reviews the consequences of the so-called 'feminine emancipation' in terms of stress from two main sources:(1) the relationship between stress, hormones and PMS; (2) stress as a consequence of the 'triple working time' (the accumulation of the roles played by women: worker, wife and mother). We conclude that such discourses on female stress collaborate to confirm that certain sources of tension, as well as how to deal with them, are regard as been morally and physiologically concerned to women.


Considerado una 'epidemia global' por la Organización Mundial de la Salud (OMS), el estrés figura como uno de los principales trastornos contemporáneos. En este artículo, examinamos las construcciones discursivas sobre el estrés femenino, o sea, cuando el término está específicamente relacionado con las mujeres. Para cumplir nuestro objetivo, se realizó un análisis del discurso de la revista brasileña Veja de 2000 a 2018. Nuestra intención es observar las formas como esta revista estima las consecuencias de la 'emancipación de la mujer' concerniente al estrés a partir de dos aspectos principales: (1) la relación entre estrés, hormonas y TPM; (2) el estrés como consecuencia de la 'triple jornada de trabajo' (la acumulación de sus papeles de profesional, esposa y madre). Concluimos que tales discursos sobre el estrés femenino colaboran para asegurar que algunas fuentes de tensión, así como el modo de hacer frente a ellas, sean moralmente y fisiológicamente relacionadas con las mujeres.


Assuntos
Humanos , Qualidade de Vida , Estresse Psicológico , Mulheres Trabalhadoras , Identidade de Gênero , Ansiedade , Publicações Seriadas , Jornada de Trabalho , Menopausa , Saúde da Mulher , Feminização , Estilo de Vida
12.
Br J Radiol ; 92(1103): 20190417, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31398071

RESUMO

OBJECTIVES: In magnetic resonance imaging (MRI), background parenchymal enhancement (BPE) is associated with breast cancer risk, but the associations between BPE and clinical characteristics and histological features are unknown. This study aimed to investigate the association between BPE and clinical characteristics (including age, menopausal status, and tumor histological characteristics) in patients with invasive breast cancer. METHODS: This was a retrospective study of 163 patients with invasive breast cancer (164 lesions, 1 patient had bilateral cancer) confirmed by surgery and pathological examination, treated between January 2014 and December 2016 at our university (Kunming Medical University). The patients were divided into two groups: extremely minimal and mild enhancement (low BPE group, n = 78) vs moderate and marked enhancement (high BPE group, n = 86). RESULTS: Compared with the low BPE group, the high BPE group showed higher frequencies of patients < 50 years of age (88% vs 38%, p < 0.0001), premenopausal (87% vs 29%, p < 0.0001), T1 staging (35% vs 15%, p = 0.027), Grade II (57% vs 37%, p = 0.03), lymphovascular invasion (83% vs 13%, p < 0.0001), and positive estrogen receptor (ER) (79% vs 42%, p < 0.0001). The Spearman correlation coefficients (r) between BPE and age, menopausal status, lymphovascular invasion, and ER status were -0.521 (p < 0.0001), -0.588 (p < 0.0001), 0.697 (p < 0.0001), and 0.377 (p < 0.0001), respectively. CONCLUSION: BPE is negatively associated with age and menopausal status, and is positively associated with lymphovascular invasion and positive ER status. ADVANCES IN KNOWLEDGE: BPE is not correlated with T staging and histological classification in patients with invasive breast cancer.


Assuntos
Neoplasias da Mama/patologia , Receptores Estrogênicos/metabolismo , Adulto , Idoso , Feminino , Humanos , Metástase Linfática , Imagem por Ressonância Magnética , Menopausa/psicologia , Pessoa de Meia-Idade , Invasividade Neoplásica , Estudos Retrospectivos , Adulto Jovem
13.
Eur J Histochem ; 63(3)2019 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-31455072

RESUMO

The aim of this study was to describe the structural and ultrastructural aspects of the myotendinous junction (MTJ) and the proximal and distal sarcomeres of the sternomastoid of aged Wistar rats subjected to an experimental model of menopause and swimming training. A total of 20 female elderly rats were divided into the following four groups (n=5 in each group): sedentary/no-menopausal (SNM), trained/no-menopausal (TNM), sedentary/menopausal (SM), and trained/menopausal (TM). The MTJ samples were dissected and analyzed using transmission electron microscopy. We showed that the TNM Group rats exhibited changes in morphological characteristics as a consequence of physical exercise, which included an increase of 36.60% (P<0.001) in the evagination length of the MTJ and a reduction in the length of the distal (77.38%) (P<0.0001) and proximal (68.15%) (P<0.0001) sarcomeres. The SM Group exhibited a reduction of about 275.93% (P<0.001) in the muscle-tendon interface and in the lengths of distal sarcomeres (55.87%) (P<0.0001) compared with SNM Group. Our results suggest that the swimming training under experimental model of menopause promoted tissue reorganization and increased muscle-tendon interaction with a drastic development in the length and thickness of the sarcoplasmatic invaginations and evaginations. In addition, the sarcomeres exhibited different lengths and a reduction in both groups subjected to swimming training.


Assuntos
Menopausa/fisiologia , Músculos do Pescoço/metabolismo , Condicionamento Físico Animal , Sarcômeros/metabolismo , Tendões/metabolismo , Animais , Feminino , Microscopia Eletrônica de Transmissão , Músculos do Pescoço/ultraestrutura , Ratos Wistar , Sarcômeros/ultraestrutura , Natação , Tendões/ultraestrutura
15.
Zhen Ci Yan Jiu ; 44(7): 516-9, 2019 Jul 25.
Artigo em Chinês | MEDLINE | ID: mdl-31368284

RESUMO

OBJECTIVE: To observe the therapeutic effect of body acupuncture combined with auricular acupuncture in the treatment of woman menopause insomnia induced by disharmony between the heart and kidney. METHODS: A total of 111 outpatients with menopausal insomnia were randomly divided into treatment group (n=55, body acupoints plus auricular points) and control group (n=56, body acupoints). For control group, Shenmen (HT7), Sanyinjiao (SP6), Anmian, Zhaohai (KI6), Shenmai (BL62), Sishencong (EX-HN1), Xinshu (BL15) and Shenshu (BL21) were needled with filiform needles, and HT7, SP6, Anmian, BL15 and BL21 were also stimulated with electroacupuncture (EA) for 30 min, once every other day, 3 times a week for 3 weeks. For the treatment group, auricular points as Kidney, Shenmen, Sympathetic and Endocrine around the ear canal and the ear cavity were punctured with filiform needles in combination with the same intervention methods mentioned above in the control group. The quality and efficiency of sleep were assessed by using Pittsburgh Sleep Quality Index (PSQI) scale before and after the treatment. The symptom scores of traditional Chinese medicine (TCM) and the therapeutic effect were determined according to the "Guide Principles for Clinical Research of New Drugs of TCM" (formulated by Chinese Ministry of Health, 1997). RESULTS: After the treatment, the scores of sleep quantity and effective rate of PSQI scale, and those of insomnia and dreaminess, dysphoria with feverish sensation in chest, palms and soles, paplpitation and irritability, fatigue and forgetfulness of TCM were reduced significantly in both groups compared with their own pre-treatment (P<0.05). Of the 56 and 55 cases in the control and treatment groups, 18 (32.1%) and 30 (54.5%) experienced a marked improvement in their symptoms, 28 (50.0%) and 22 (40.0%) were effective, and 10 (17.9%) and 3 (5.5%) failed, with the effective rate being 82.1% and 94.5%, respectively. The therapeutic effect of stimulation of the body acupoints plus auricular acupoints was significantly superior to that of stimulation of simple body acupoints in lowering scores of PSQI scale, insomnia and dreaminess, dysphoria with feverish sensation in chest, palms and soles, dizziness and tinninus, paplpitation and irritability, and tital fever and night sweating of TCM, as well as the effective rate (P<0.05). CONCLUSION: Both body acupuncture and body acupuncture combined with auricular acupuncture are effective in the treatment of woman menopause insomnia due to disharmony between the heart and kidney, and the two combined treatment was evidently better.


Assuntos
Acupuntura Auricular , Distúrbios do Início e da Manutenção do Sono , Pontos de Acupuntura , Feminino , Coração , Humanos , Rim , Menopausa , Distúrbios do Início e da Manutenção do Sono/terapia , Resultado do Tratamento
16.
Cas Lek Cesk ; 158(3-4): 101-106, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31416315

RESUMO

About 40 % of woman suffer from vulvovaginal atrophy after menopausal transition. It is very important to put question on this problem, because about 70 % of them are not able to start discussion on it. Regarding treatment, vaginal low doses estriol and estradiol are drugs of first choice with high efficacy and safety.


Assuntos
Menopausa , Doenças Vaginais , Doenças da Vulva , Atrofia , Feminino , Humanos , Síndrome , Vagina , Doenças Vaginais/diagnóstico , Doenças Vaginais/terapia , Doenças da Vulva/diagnóstico , Doenças da Vulva/terapia
17.
Cas Lek Cesk ; 158(3-4): 107-111, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31416316

RESUMO

Tibolon is the only therapeutic approach to climacteric symptoms, prevention of osteoporosis and urogenital atrophy with the same efficacy as hormone replacement therapy. Tibolon has more positive effects on sexuality and mood changes in menopausal women. It decreases the mammographic density. Its safety for breast cancer is the same as for only estrogen therapy and better than for estrogen-gestagen therapy. Tibolon is the first choice for postmenopausal women with mood and sexuality disorders, women with mastodynia and high mammographic density.


Assuntos
Moduladores de Receptor Estrogênico , Norpregnenos , Osteoporose , Neoplasias da Mama/induzido quimicamente , Clima , Moduladores de Receptor Estrogênico/efeitos adversos , Moduladores de Receptor Estrogênico/uso terapêutico , Estrogênios , Feminino , Humanos , Menopausa , Norpregnenos/efeitos adversos , Norpregnenos/uso terapêutico , Osteoporose/prevenção & controle , Progestinas
18.
Artigo em Russo | MEDLINE | ID: mdl-31329189

RESUMO

BACKGROUND: The problem of ensuring long-term well-being and high quality of life for older women is becoming the most important goal of modern medicine. The initial presence of metabolic syndrome complicates the course of menopause; and menopausal hormone therapy cannot always be used. The urgency for finding the effective ways of non-drug correction of menopausal disorders in this category of patients is obvious. AIM: To comparatively evaluate the effectiveness of complex non-drug programs in the correction of psychoemotional disorders of menopause in patients with metabolic syndrome. MATERIAL AND METHODS: A total of 330 women aged 45-50 years with menopausal syndrome in the presence of metabolic syndrome were examined. The examinees were randomized into 5 groups. All the patients received conventional treatment. A study and comparison groups used exercise therapy, drank mineral water, and additionally took multivitamins and minerals. The physiotherapeutic component of therapeutic complexes was represented by various combinations of factors (vibrotherapy, chromotherapy, melotherapy, aromatherapy, and aeroionotherapy). The control group received conventional treatment only. The degree of severity of psychoemotional disorders was estimated before and 3 and 6 months after treatment via the modified Kupperman menopausal index (MMI), the Spielberger-Khanin Trait Anxiety Inventory, and the Hamilton Depression Rating Scale. RESULTS: Psychoemotional symptoms were most significantly reduced (1.5-fold) after 6 months of treatment in patients with mild disorders when the complexes, including vibrotherapy, were applied. In patients with moderate disorders, the simultaneous use of vibrotherapy, chromotherapy, melotherapy, aromatherapy, and aeroionotherapy promoted the maximum regression of psychoemotional symptoms (by 47.3%) (p<0.05). The application of the conventional approach was observed to aggravate psychoemotional disorders. CONCLUSION: Complex non-drug programs, including physiotherapy, effectively relieve perimenopausal psychoemotional disorders in patients with metabolic syndrome. Vibrotherapy substantially improves the results of treatment. Moderate psychoemotional disorders need the complex program to be applied simultaneously with vibrotherapy, chromotherapy, melotherapy, aromatherapy, and aeroionotherapy.


Assuntos
Transtornos de Ansiedade/prevenção & controle , Transtorno Depressivo/prevenção & controle , Menopausa/psicologia , Síndrome Metabólica/terapia , Feminino , Humanos , Pessoa de Meia-Idade , Modalidades de Fisioterapia , Avaliação de Programas e Projetos de Saúde , Resultado do Tratamento
19.
Zh Nevrol Psikhiatr Im S S Korsakova ; 119(4. Vyp. 2): 44-49, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31317914

RESUMO

AIM: To evaluate the features of sleep disorders in Caucasian and Asian menopausal women. MATERIAL AND METHODS: Five hundreds and forty-two menopausal women, aged 45 to 60 years, were divided into Caucasians (Russians (n=342)) and Asians (Buryats (n=200)). All women were examined by an obstetrician-gynecologist. Also, a general clinical examination and an analysis of medical documentation were conducted. Diagnoses of insomnia and obstructive sleep apnea syndrome (OSAS) were made according to the results of specialized somnological questionnaires and polysomnographic monitoring. RESULTS: The frequency of sleep disorders in Caucasian women in perimenopause was 61.2%, in postmenopause 65.5%; in Asian women it was 63.5% in perimenopause, 72.9% in postmenopause. Difficulties in falling asleep (69.4%) and difficulties in morning awakenings (63.5%) were found in perimenopausal Caucasian women and frequent nightly awakenings (83.5%) and OSAS (48.9%) were found in postmenopausal ones. There were no differences in the structure of sleep disorders depending on the menopause phase in Asian women. The most common complaints were frequent nighttime awakenings (69.5% in perimenopause, 76.9% in postmenopause). Ethnic differences in the sleep complaints were found only in the perimenopause. The decrease in sleep efficacy and changes in the rapid eye movement sleep were found in Asian women as compared to Caucasians. Moreover, apnea-hypopnea index was higher and oxygen saturation was lower in Asian women compared to Caucasians. CONCLUSION: The formation of sleep disorders in menopausal women has ethnogenetic features.


Assuntos
Menopausa , Distúrbios do Início e da Manutenção do Sono , Transtornos do Sono-Vigília , Feminino , Humanos , Menopausa/etnologia , Pessoa de Meia-Idade , Perimenopausa , Federação Russa , Sono , Distúrbios do Início e da Manutenção do Sono/etnologia , Transtornos do Sono-Vigília/etnologia
20.
Zh Nevrol Psikhiatr Im S S Korsakova ; 119(4. Vyp. 2): 105-111, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31317923

RESUMO

AIM: To study the characteristics of somnological status in women in the late reproductive, pre- and postmenopausal periods before and after partial light deprivation. MATERIAL AND METHODS: One hundred and eighty-four women of menopausal age were included. A polysomnographic study of night sleep was performed and the excretion of the morning fraction of 6-sulfatoxymelatonin in the urine was measured before and after partial light deprivation in the light-saturated months of the year (from April to October) using optical lenses with a mineral photochromic coating. RESULTS AND CONCLUSIONS: The following characteristics of sleep for women with a neuro-vegetative form of menopausal syndrome are identified: the deterioration in the overall effectiveness of sleep, consisting in the increase of 'apnea-hypopnea sleep' in women in premenopause and menopause compared to women in late reproductive period, the increase in the duration of superficial stages of slow-wave sleep, the decrease in the duration of paradoxical sleep, the prevalence of slow-wave sleep in all sleep cycles, the decrease in the duration of paradoxical sleep, the increase in wakefulness in sleep, motor activity and desaturation during sleep that is accompanied by the decrease in the level of 6-sulfate-oxymelatonin in the morning urine compared to women in the late reproductive period. After the use of partial light deprivation, the parameters of the subjective assessment of sleep quality improved in the majority of women and polysomnographic patterns, including the significant increase in melatonin production, reached the normal levels.


Assuntos
Perimenopausa , Transtornos do Sono-Vigília , Adulto , Feminino , Humanos , Menopausa , Pessoa de Meia-Idade , Pós-Menopausa , Pré-Menopausa , Sono
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA