Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 595
Filtrar
1.
PLoS One ; 14(12): e0226609, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31877169

RESUMO

Minerals, such as zinc, copper, and iron are reported to play roles in chronic infectious diseases; however, their role in paracoccidioidomycosis (PCM) remains unknown. This study aimed to examine the micronutrient dynamics and their correlation with serum proteins and thyroid hormones in patients with PCM. In 14 patients with PCM and 10 healthy subjects, we evaluated the body mass index (BMI) along with serum levels of hemoglobin, iron, ferritin, zinc, copper, magnesium, albumin, globulin, thyroid stimulating hormone (TSH), thyroxine (free T4), and triiodothyronine (T3). Evaluations were conducted at the first appointment, before treatment, and at the end of the first, second, fourth, and sixth month of PCM treatment. The control group was only evaluated once. We observed that before treatment, patients with PCM, had higher levels of copper and lower level of iron than those of the control group. After one month of treatment, the iron levels increased, whereas the levels of copper after six months of treatment. Reduction in inflammatory activity, indicated by the normalization of C-reactive protein, ferritin, albumin, and globulin levels, was observed during treatment. However, no correlation was observed between the serum levels of minerals and inflammatory activity or thyroid function in this study. In conclusion, our results showed higher serum copper levels in control group compared to those in pretreatment patients; the clinical importance of this observation should be investigated in further studies. After treatment, serum copper levels showed a tendency to decrease. In addition, serum iron levels were decreased at the stage of active disease, and were increased after treatment. Thus, serum iron levels can be used as a better biomarker for treatment control.


Assuntos
Proteínas Sanguíneas/análise , Micronutrientes/sangue , Paracoccidioidomicose/sangue , Hormônios Tireóideos/sangue , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Paracoccidioides/isolamento & purificação , Paracoccidioidomicose/diagnóstico
2.
J Korean Med Sci ; 34(32): e204, 2019 Aug 19.
Artigo em Inglês | MEDLINE | ID: mdl-31432649

RESUMO

BACKGROUND: It has been known that vitamin D level (serum 25[OH]D) has correlation with inflammatory bowel disease (IBD). The purpose of this study is to investigate changes of serum 25[OH]D in pediatric IBD patients according to the disease activity. METHODS: A total of 96 children and adolescent with IBD were enrolled in this retrospective study. Serologic inflammatory markers and clinical disease activity scores of the patients were collected, and their correlations with serum 25[OH]D were analyzed. Seasonal variations of serum 25[OH]D were also investigated both in active disease state and remission state. RESULTS: Of the 96 patients, 41 (43%) were women and patients with a vitamin D deficiency (< 20 ng/mL) at diagnosis were 77 (80.2%). There was no significant difference between Crohn's disease and ulcerative colitis for serum 25[OH]D. Serum 25[OH]D was higher in remission group than in active disease group (12.4 [8.8-29] ng/mL vs. 17.9 [12.3-34.4] ng/mL; P < 0.001) and the difference was more significant than other micronutrients. There was no significant difference in serum 25[OH]D concentration between patients with ileal involvement and patients without ileal involvement. There were seasonal variations in the active phase, but there was no significant difference by season in the remission phase. CONCLUSION: Serum 25[OH]D is inversely correlated with disease activity in IBD. Monitoring and supplementation is required especially for active disease status and in winter and spring season.


Assuntos
Calcifediol/sangue , Doenças Inflamatórias Intestinais/diagnóstico , Adolescente , Biomarcadores/sangue , Criança , Colite Ulcerativa/diagnóstico , Colite Ulcerativa/patologia , Doença de Crohn/diagnóstico , Doença de Crohn/patologia , Feminino , Humanos , Doenças Inflamatórias Intestinais/patologia , Masculino , Micronutrientes/sangue , Estudos Retrospectivos , Estações do Ano , Índice de Gravidade de Doença , Deficiência de Vitamina D/sangue , Deficiência de Vitamina D/diagnóstico
3.
Nutrients ; 11(9)2019 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-31461828

RESUMO

Phenylketonuria (PKU) is treated with dietary restrictions and sometimes tetrahydrobiopterin (BH4). PKU patients are at risk for developing micronutrient deficiencies, such as vitamin B12 and folic acid, likely due to their diet. Tyrosinemia type 1 (TT1) is similar to PKU in both pathogenesis and treatment. TT1 patients follow a similar diet, but nutritional deficiencies have not been investigated yet. In this retrospective study, biomarkers of micronutrients in TT1 and PKU patients were investigated and outcomes were correlated to dietary intake and anthropometric measurements from regular follow-up measurements from patients attending the outpatient clinic. Data was analyzed using Kruskal-Wallis, Fisher's exact and Spearman correlation tests. Furthermore, descriptive data were used. Overall, similar results for TT1 and PKU patients (with and without BH4) were observed. In all groups high vitamin B12 concentrations were seen rather than B12 deficiencies. Furthermore, all groups showed biochemical evidence of vitamin D deficiency. This study shows that micronutrients in TT1 and PKU patients are similar and often within the normal ranges and that vitamin D concentrations could be optimized.


Assuntos
Aminoácidos/administração & dosagem , Dieta com Restrição de Proteínas , Suplementos Nutricionais , Micronutrientes/sangue , Estado Nutricional , Fenilcetonúrias/dietoterapia , Tirosinemias/dietoterapia , Adolescente , Adulto , Idoso , Aminoácidos/efeitos adversos , Biomarcadores/sangue , Biopterina/análogos & derivados , Biopterina/uso terapêutico , Criança , Pré-Escolar , Cicloexanonas/uso terapêutico , Dieta com Restrição de Proteínas/efeitos adversos , Suplementos Nutricionais/efeitos adversos , Inibidores Enzimáticos/uso terapêutico , Feminino , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Nitrobenzoatos/uso terapêutico , Fenilcetonúrias/sangue , Fenilcetonúrias/diagnóstico , Fenilcetonúrias/fisiopatologia , Estudos Retrospectivos , Medição de Risco , Fatores de Risco , Tirosinemias/sangue , Tirosinemias/fisiopatologia , Deficiência de Vitamina B 12/sangue , Deficiência de Vitamina B 12/diagnóstico , Deficiência de Vitamina B 12/etiologia , Deficiência de Vitamina D/sangue , Deficiência de Vitamina D/diagnóstico , Deficiência de Vitamina D/etiologia , Adulto Jovem
4.
Medicina (Kaunas) ; 55(7)2019 Jul 03.
Artigo em Inglês | MEDLINE | ID: mdl-31277328

RESUMO

Background and objective: Often micronutrient deficiencies cannot be detected when patient is already following a long-term gluten-free diet with good compliance (LTGFDWGC). The aim of this narrative review is to evaluate the most recent literature that considers blood micronutrient deficiencies in LTGFDWGC subjects, in order to prepare dietary supplementation advice (DSA). Materials and methods: A research strategy was planned on PubMed by defining the following keywords: celiac disease, vitamin B12, iron, folic acid, and vitamin D. Results: This review included 73 studies. The few studies on micronutrient circulating levels in long-term gluten-free diet (LTGFD) patients over 2 years with good compliance demonstrated that deficiency was detected in up to: 30% of subjects for vitamin B12 (DSA: 1000 mcg/day until level is normal, then 500 mcg), 40% for iron (325 mg/day), 20% for folic acid (1 mg/day for 3 months, followed by 400-800 mcg/day), 25% for vitamin D (1000 UI/day or more-based serum level or 50,000 UI/week if level is <20 ng/mL), 40% for zinc (25-40 mg/day), 3.6% of children for calcium (1000-1500 mg/day), 20% for magnesium (200-300 mg/day); no data is available in adults for magnesium. Conclusions: If integration with diet is not enough, starting with supplements may be the correct way, after evaluating the initial blood level to determine the right dosage of supplementation.


Assuntos
Doença Celíaca/dietoterapia , Dieta Livre de Glúten/efeitos adversos , Micronutrientes/análise , Adolescente , Adulto , Cálcio/análise , Cálcio/sangue , Doença Celíaca/sangue , Doença Celíaca/tratamento farmacológico , Criança , Dieta Livre de Glúten/métodos , Suplementos Nutricionais/normas , Feminino , Ácido Fólico/análise , Ácido Fólico/sangue , Humanos , Ferro/análise , Ferro/sangue , Masculino , Micronutrientes/sangue , Cooperação do Paciente/psicologia , Vitamina B 12/análise , Vitamina B 12/sangue , Vitamina D/análise , Vitamina D/sangue , Zinco/análise , Zinco/sangue
5.
J Perinat Med ; 47(7): 724-731, 2019 Sep 25.
Artigo em Inglês | MEDLINE | ID: mdl-31318696

RESUMO

Background Pregnancy is associated with biochemical changes leading to increased nutritional demands for the developing fetus that result in altered micronutrient status. The Indian dietary pattern is highly diversified and the data about dietary intake patterns, blood micronutrient profiles and their relation to low birthweight (LBW) is scarce. Methods Healthy pregnant women (HPW) were enrolled and followed-up to their assess dietary intake of nutrients, micronutrient profiles and birthweight using a dietary recall method, serum analysis and infant weight measurements, respectively. Results At enrolment, more than 90% of HPW had a dietary intake below the recommended dietary allowance (RDA). A significant change in the dietary intake pattern of energy, protein, fat, vitamin A and vitamin C (P < 0.001) was seen except for iron (Fe) [chi-squared (χ2) = 3.16, P = 0.177]. Zinc (Zn) deficiency, magnesium deficiency (MgDef) and anemia ranged between 54-67%, 18-43% and 33-93% which was aggravated at each follow-up visit (P ≤ 0.05). MgDef was significantly associated with LBW [odds ratio (OR): 4.21; P = 0.01] and the risk exacerbate with the persistence of deficiency along with gestation (OR: 7.34; P = 0.04). Pre-delivery (OR: 0.57; P = 0.04) and postpartum (OR: 0.37; P = 0.05) anemia, and a vitamin A-deficient diet (OR: 3.78; P = 0.04) were significantly associated with LBW. LBW risk was much higher in women consuming a vitamin A-deficient diet throughout gestation compared to vitamin A-sufficient dietary intake (OR: 10.00; P = 0.05). Conclusion The studied population had a dietary intake well below the RDA. MgDef, anemia and a vitamin A-deficient diet were found to be associated with an increased likelihood of LBW. Nutrient enrichment strategies should be used to combat prevalent micronutrient deficiencies and LBW.


Assuntos
Deficiências Nutricionais , Dieta/métodos , Recém-Nascido de Baixo Peso/metabolismo , Micronutrientes , Complicações na Gravidez , Adulto , Peso ao Nascer/fisiologia , Deficiências Nutricionais/sangue , Deficiências Nutricionais/diagnóstico , Deficiências Nutricionais/epidemiologia , Deficiências Nutricionais/etiologia , Comportamento Alimentar/fisiologia , Feminino , Humanos , Índia/epidemiologia , Micronutrientes/sangue , Micronutrientes/classificação , Micronutrientes/deficiência , Determinação de Necessidades de Cuidados de Saúde , Gravidez , Complicações na Gravidez/sangue , Complicações na Gravidez/diagnóstico , Complicações na Gravidez/epidemiologia , Complicações na Gravidez/etiologia , Serviços Preventivos de Saúde , Recomendações Nutricionais , Fatores de Risco
6.
Biomed Res Int ; 2019: 5070453, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31312657

RESUMO

Background: Obesity and pregnancy increase levels of maternal oxidative stress (OS). However, little is known about the maternal, placental, and neonatal OS status. Objective: To analyze the relation between prepregnancy obesity and the expression of OS markers and antioxidant capacity in the fetomaternal unit and their association with dietary intake. Methods: This cross-sectional study included 33 women with singleton, noncomplicated pregnancies. Two groups were formed: women with prepregnancy body mass index (pBMI) within normal range (18.5-24.9 kg/m2, n = 18) and women with pBMI ≥ 30 kg/m2, suggestive of obesity (n = 15). Dietary and clinical information was obtained by questionnaire and from clinical records. Total antioxidant capacity (TAC) and malondialdehyde (MDA) concentration were measured on maternal and cord serum by colorimetric techniques, and placental expression of glutathione peroxidase 4 (GPx4) was measured by immunohistochemistry. Results: Placental GPx4 expression was lower in the group with pBMI suggestive of obesity than in the normal weight group (ß = -0.08, p = 0.03, adjusted for gestational age and magnesium intake). Concentrations of TAC and MDA in maternal and cord blood were not statistically different between groups (p>0.05). Cord MDA concentration was related to maternal MDA concentration (ß = 0.40, p < 0.01), vitamin A intake (tertile 2: ß = -0.04, p = 0.40, tertile 3: ß = 0.13, p = 0.03, vs tertile 1), and placental GPx4 expression (ß = -0.09, p = 0.02). Conclusion: Prepregnancy obesity is associated with a decrease in GPx4 expression in the placenta, which is related to OS in the newborn. The influence of micronutrient intake on OS biomarkers highlights the importance of nutritional assessment during pregnancy and adequate prenatal care.


Assuntos
Micronutrientes/sangue , Estresse Oxidativo/genética , /sangue , Adulto , Antioxidantes/metabolismo , Índice de Massa Corporal , Ingestão de Alimentos/fisiologia , Feminino , Regulação Enzimológica da Expressão Gênica , Humanos , Malondialdeído/sangue , Relações Materno-Fetais/fisiologia , Mães , Avaliação Nutricional , /fisiopatologia , Placenta/metabolismo , Gravidez , Vitamina A/sangue
7.
Nutrients ; 11(6)2019 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-31197107

RESUMO

BACKGROUND: Institutionalized elderly are at higher risk for micronutrient deficiency. In particular, fat soluble micronutrients, which additionally have antioxidative function, are of interest. The purpose of this secondary investigation of the Vienna Active Ageing Study was to assess and evaluate the plasma status of retinol, alpha- and gamma-tocopherol, alpha- and beta-carotene, lutein, zeaxanthin, beta-cryptoxanthin, and lycopene, as well as vitamin D (25(OH)D) in a cohort of institutionalized elderly. We further determined the effect of six months strength training with or without supplementing (antioxidant) vitamins and protein on the plasma status of these ten micronutrients. METHODS: Three groups (n = 117, age = 83.1 ± 6.1 years)-resistance training (RT), RT combined with protein and vitamin supplementation (RTS), or cognitive training (CT)-performed two guided training sessions per week for six months. Micronutrients were measured with High Performance Liquid Chromatography (HPLC) at baseline and after 6 months of intervention. Physical fitness was assessed by the 6-min-walking, the 30-s chair rise, isokinetic dynamometry, and the handgrip strength tests. RESULTS: At baseline, the plasma status of retinol was satisfactory, for alpha-tocopherol, beta-carotene, and 25(OH)D, the percentage of individuals with an insufficient status was 33%, 73% and 61%/81% (when using 50 nmol/L or 75 nmol/L as threshold levels for 25(OH)D), respectively. Plasma analyses were supported by intake data. Six months of elastic band resistance training with or without protein-vitamin supplementation had no biological impact on the status of fat soluble micronutrients. Even for vitamin D, which was part of the nutritional supplement (additional 20 µg/d), the plasma status did not increase significantly, however it contributed to a lower percentage of elderly below the threshold levels of 50/75 nmol/L (49%/74%). CONCLUSIONS: The findings of the study lead to the strong recommendation for regular physical activity and increased consumption of plant-based foods in institutionalized elderly. When supported by blood analysis, supplementing micronutrients in a moderate range should also be considered.


Assuntos
Cognição/efeitos dos fármacos , Suplementos Nutricionais , Micronutrientes/farmacologia , Estado Nutricional/efeitos dos fármacos , Vitaminas/farmacologia , Idoso , Idoso de 80 Anos ou mais , Áustria , Proteínas na Dieta/farmacologia , Exercício , Feminino , Habitação para Idosos , Humanos , Masculino , Micronutrientes/sangue , Aptidão Física , Treinamento de Resistência , Vitaminas/sangue
8.
Nutrients ; 11(6)2019 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-31181624

RESUMO

BACKGROUND: People living with human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) (PLWH) are at an increased risk of cardiovascular disease. Diet-related factors may contribute. The aim of this pilot study was to determine, in PLWH, the relationship between atherosclerosis assessed by carotid intima-media thickness (CIMT) and (A) plasma antioxidant micronutrients and oxidative stress or (B) red blood cell polyunsaturated fatty acids (RBC PUFA), particularly long chain omega-3 polyunsaturated fatty acids (n-3 PUFA). METHODS: (A) In a cross-sectional study, subjects had CIMT evaluated by high resolution carotid artery ultrasound. Plasma was collected for vitamin C, measured by spectrophotometry; and alpha- and gamma-tocopherol, retinol, and malondialdehyde-a marker of oxidative stress-using high pressure liquid chromatography and fluorescence spectrophotometry. (B) In a prospective cohort study, other subjects had RBC PUFA measured at baseline, using gas chromatography, and CIMT assessed at baseline and repeated after 2 years. Clinical data was also collected. RESULTS: (A) 91 PLWH participated. Only alpha- and gamma-tocopherol levels were positively correlated with CIMT. In a multivariate analysis, age and systolic blood pressure were significantly associated with CIMT with gamma-tocopherol near significance (p = 0.053). (B) 69 PLWH participated. At baseline, docosahexaenoic acid (n-3 PUFA) and the ratio of docosahexaenoic acid to arachidonic acid (n-6 PUFA) were significantly and negatively correlated with CIMT. However, a multivariate analysis failed to detect a significant relationship either at baseline or 2 years after. CONCLUSION: In addition to age and systolic blood pressure, atherosclerosis assessed by CIMT might be associated with higher serum gamma-tocopherol levels. There was a non-significant association between CIMT and RBC n-3 PUFA or the ratio of n-3 to n-6 PUFA.


Assuntos
Antioxidantes/metabolismo , Aterosclerose/etiologia , Eritrócitos/metabolismo , Ácidos Graxos Insaturados/sangue , Infecções por HIV/complicações , Estresse Oxidativo , gama-Tocoferol/sangue , Adulto , Ácido Araquidônico/sangue , Aterosclerose/sangue , Aterosclerose/patologia , Pressão Sanguínea , Espessura Intima-Media Carotídea , Estudos Transversais , Ácidos Docosa-Hexaenoicos/sangue , Feminino , Infecções por HIV/sangue , Infecções por HIV/patologia , Humanos , Masculino , Malondialdeído/sangue , Micronutrientes/sangue , Pessoa de Meia-Idade , Análise Multivariada , Projetos Piloto , Estudos Prospectivos , alfa-Tocoferol/sangue
9.
Nutrients ; 11(5)2019 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-31121930

RESUMO

Vegetarian diets have gained popularity in sports. However, few data exist on the status of micronutrients and related biomarkers for vegetarian and vegan athletes. The aim of this cross-sectional study was to compare the micronutrient status of omnivorous (OMN, n = 27), lacto-ovo-vegetarian (LOV, n = 26), and vegan (VEG, n = 28) recreational runners. Biomarkers of vitamin B12, folate, vitamin D, and iron were assessed. Additionally, serum levels of calcium, magnesium, and zinc were examined. Lifestyle factors and supplement intake were recorded via questionnaires. About 80% of each group showed vitamin B12 adequacy with higher levels in supplement users. Mean red blood cell folate exceeded the reference range (>340 nmol/L) in all three groups (OMN: 2213 ± 444, LOV: 2236 ± 596, and VEG: 2354 ± 639 nmol/L; not significant, n.s.). Furthermore, vitamin D levels were comparable (OMN: 90.6 ± 32.1, LOV: 76.8 ± 33.7, and VEG: 86.2 ± 39.5 nmol/L; n.s.), and we found low prevalence (<20%) of vitamin D inadequacy in all three groups. Less than 30% of each group had depleted iron stores, however, iron deficiency anemia was not found in any subject. Our findings suggest that a well-planned, health-conscious lacto-ovo-vegetarian and vegan diet, including supplements, can meet the athlete's requirements of vitamin B12, vitamin D and iron.


Assuntos
Dieta Vegetariana , Dieta , Micronutrientes , Estado Nutricional , Corrida/fisiologia , Adulto , Biomarcadores/sangue , Estudos Transversais , Dieta Vegana , Humanos , Ferro/administração & dosagem , Ferro/deficiência , Masculino , Micronutrientes/administração & dosagem , Micronutrientes/sangue , Necessidades Nutricionais , Veganos , Vitamina B 12/administração & dosagem , Vitamina B 12/sangue , Vitamina D/administração & dosagem , Vitamina D/sangue , Deficiência de Vitamina D/sangue
10.
Am J Clin Nutr ; 110(1): 131-138, 2019 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-31127812

RESUMO

BACKGROUND: Poor growth in early childhood has been associated with increased risk of mortality and morbidity, as well as long-term deficits in cognitive development and economic productivity. OBJECTIVES: Data from the MAL-ED cohort study were used to identify factors in the first 2 y of life that are associated with height-for-age, weight-for-age, and body mass index z-scores (HAZ, WAZ, BMIZ) at 5 y of age. METHODS: A total of 1017 children were followed from near birth until 5 y of age at sites in Bangladesh, Brazil, India, Nepal, Peru, South Africa, and Tanzania. Data were collected on their growth, environmental enteric dysfunction (EED), micronutrient status, enteric pathogen burden, illness prevalence, dietary intake, and various other socio-economic and environmental factors. RESULTS: EED biomarkers were related to size at 5 y. Mean lactulose:mannitol z-scores during the first 2 y of life were negatively associated with all of the growth measures (HAZ: -0.11 [95% CI: -0.19, -0.03]; WAZ: -0.16 [95% CI: -0.26, -0.06]; BMIZ: -0.11 [95% CI: -0.23, 0.0]). Myeloperoxidase was negatively associated with weight (WAZ: -0.52 [95% CI: -0.78, -0.26] and BMIZ: -0.56 [95% CI: -0.86, -0.26]); whereas α-1-antitrypsin had a negative association with HAZ (-0.28 [95% CI: -0.52, -0.04]). Transferrin receptor was positively related to HAZ (0.18 [95% CI: 0.06, 0.30]) and WAZ (0.21 [95% CI: 0.07, 0.35]). Hemoglobin was positively related to HAZ (0.06 [95% CI: 0.00, 0.12]), and ferritin was negatively related to HAZ (-0.08 [95% CI: -0.12, -0.04]). Bacterial density in stool was negatively associated with HAZ (-0.04 [95% CI: -0.08, 0.00]), but illness symptoms did not have any effect on size at 5 y. CONCLUSIONS: EED markers, bacterial density, and iron markers are associated with growth at 5 y of age. Interventions to reduce bacterial burden and EED may improve long-term growth in low-income settings.


Assuntos
Tamanho Corporal/fisiologia , Transtornos do Crescimento/epidemiologia , Enteropatias/fisiopatologia , Bangladesh/epidemiologia , Biomarcadores/urina , Estatura , Índice de Massa Corporal , Peso Corporal , Brasil/epidemiologia , Pré-Escolar , Estudos de Coortes , Fezes/química , Fezes/microbiologia , Feminino , Seguimentos , Humanos , Índia/epidemiologia , Lactente , Recém-Nascido , Enteropatias/microbiologia , Lactulose/urina , Masculino , Manitol/urina , Micronutrientes/sangue , Nepal/epidemiologia , Peru/epidemiologia , África do Sul/epidemiologia , Tanzânia/epidemiologia
11.
Am J Clin Nutr ; 109(Suppl_7): 852S-871S, 2019 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-30982869

RESUMO

BACKGROUND: Proper nutrition during early life is critical for growth and development. OBJECTIVES: The aim was to describe systematic reviews conducted by the Nutrition Evidence Systematic Review team for the USDA and the Department of Health and Human Services Pregnancy and Birth to 24 Months Project to answer the following: What is the relation between 1) timing of introduction of complementary foods and beverages (CFBs) or 2) types and/or amounts of CFBs consumed and micronutrient status (iron, zinc, vitamin D, vitamin B-12, folate, and fatty acid status)? METHODS: A literature search identified articles from developed countries published from January 1980 to July 2016 that met the inclusion criteria. Data were extracted and risk of bias assessed. Evidence was qualitatively synthesized to develop a conclusion statement, and the strength of the evidence was graded. RESULTS: Nine articles addressed the timing of CFB introduction and 31 addressed types or amounts or both of CFBs. Moderate evidence suggests that introducing CFBs at age 4 mo instead of 6 mo offers no advantages or disadvantages in iron status among healthy full-term infants. Evidence is insufficient on the timing of CFB introduction and other micronutrient status outcomes. Strong evidence suggests that CFBs containing iron (e.g., meat, fortified cereal) help maintain adequate iron status or prevent deficiency in the first year among infants at risk of insufficient iron stores or low intake. Benefits for infants with sufficient iron stores (e.g., infant formula consumers) are less clear. Moderate evidence suggests that CFBs containing zinc (e.g., meat, fortified cereal) support zinc status in the first year and CFB fatty acid composition influences fatty acid status. Evidence is insufficient with regard to types and amounts of CFBs and vitamin D, vitamin B-12, and folate status, or the relation between lower-iron-containing CFBs and micronutrient status. CONCLUSIONS: Several conclusions on CFBs and micronutrient status were drawn from these systematic reviews, but more research that addresses specific gaps and limitations is needed.


Assuntos
Deficiências Nutricionais/sangue , Dieta , Comportamento Alimentar , Alimentos Infantis , Fenômenos Fisiológicos da Nutrição do Lactente , Micronutrientes/sangue , Estado Nutricional , Bebidas , Aleitamento Materno , Deficiências Nutricionais/etiologia , Deficiências Nutricionais/prevenção & controle , Suplementos Nutricionais , Ácidos Graxos/administração & dosagem , Ácidos Graxos/sangue , Ácidos Graxos/uso terapêutico , Alimentos Fortificados , Humanos , Lactente , Fórmulas Infantis , Saúde do Lactente , Micronutrientes/administração & dosagem , Micronutrientes/uso terapêutico , Oligoelementos/administração & dosagem , Oligoelementos/sangue , Oligoelementos/uso terapêutico , Vitaminas/administração & dosagem , Vitaminas/sangue , Vitaminas/uso terapêutico
12.
Int J Mol Sci ; 20(8)2019 Apr 17.
Artigo em Inglês | MEDLINE | ID: mdl-30999684

RESUMO

Goeckerman therapy (GT) of psoriasis vulgaris is based on the application of crude coal tar and ultraviolet radiation. We investigated DNA damage by the number of micronucleated binucleated cells (MNBC) in lymphocytes, serum homocysteine, vitamin B12, folic acid, and two polymorphisms (C677T and A1298C) in the MTHFR gene in 35 patients with exacerbated psoriasis vulgaris classified according to the psoriasis area and severity index (PASI) score and treated by GT. The median of PASI score decreased from nineteen to five, and MNBC increased from 10 to 18‰ after GT (p < 0.001 in both cases). Correlations of MNBC with homocysteine (Spearman's rho = 0.420, p = 0.012) and vitamin B12 (rho = -0.389, p = 0.021) before the therapy were observed. Hyperhomocysteinemia was an independent predictor of genotoxicity (OR 9.91; 95% CI, 2.09-55.67; p = 0.003). Homocysteine was higher in females than in males (13 vs. 12 µmol/L, p = 0.045). In contrast, vitamin B12 levels in the females were lower than in the males (160 vs. 192 pmol/L, p = 0.047). Vitamin B12 in the females were negatively influenced by smoking status (160 pmol/L in smokers vs. 192 pmol/L in non-smokers, p = 0.025). A significantly higher MNBC was found in CC homozygous patients (A1298C polymorphism) than in AC heterozygotes (32 vs. 16‰, p = 0.005) and AA homozygotes (32 vs. 18‰, p = 0.036). Our data showed that homocysteine participates in the pathogenesis of psoriasis. Its serum levels correlated with MNBC and allowed the prediction of DNA damage to appear within GT. Both micronutrients status and homocysteine metabolic pathway contribute to the genotoxicity of GT.


Assuntos
Alcatrão/uso terapêutico , Ceratolíticos/uso terapêutico , Metilenotetra-Hidrofolato Redutase (NADPH2)/genética , Polimorfismo de Nucleotídeo Único , Psoríase/genética , Psoríase/terapia , Terapia Ultravioleta/métodos , Adulto , Dano ao DNA/efeitos dos fármacos , Dano ao DNA/efeitos da radiação , Ácido Fólico/sangue , Homocisteína/sangue , Humanos , Testes para Micronúcleos , Micronutrientes/sangue , Pessoa de Meia-Idade , Psoríase/sangue , Psoríase/patologia , Vitamina B 12/sangue
13.
Am J Clin Nutr ; 109(5): 1484-1492, 2019 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-30976780

RESUMO

BACKGROUND: Cross-sectional (CS) surveys indicate that individuals with acute inflammation have higher plasma ferritin (pF), and lower retinol-binding protein (RBP) and zinc (pZn) concentrations than those without. In populations with a high burden of infection, correction factors (CFs) or regression corrections (RCs) are applied to biomarkers to estimate the prevalence of micronutrient (MN) deficiencies adjusted for inflammation. This assumes that individuals with and without inflammation have the same nutritional status, which may not be the case. OBJECTIVES: The aim of this study was to investigate relations between short-term, longitudinal within-individual changes in acute phase proteins (C-reactive protein [CRP], α-1-acid glycoprotein [AGP]) and biomarkers of MN status (pF, soluble transferrin receptor [sTfR], RBP, and pZn), and compare them to CS differences. METHODS: Two blood samples were obtained 21 d apart from 451 asymptomatic Burkinabé children aged 6-23 mo. To calculate CFs, inflammation was defined as CRP >5 mg/L or AGP >1 g/L, or both. The RC approach adjusted MN biomarkers to a presumably healthy reference point within the study population (10th percentile CRP or AGP concentration). CS CFs and RCs were estimated from a naive regression model, treating observations from the same children as independent. Longitudinal CFs and RCs, to estimate effects of within-individual changes in CRP and/or AGP, were estimated from general linear models, accounting for repeated measures. RESULTS: In CS models, geometric mean pF and sTfR concentrations were 8-340% greater, and RBP and pZn 2-18% lower, in children with inflammation than those without. Except for sTfR, biomarker concentrations differed in the same direction and by similar magnitude within individuals whose inflammation status changed during the observation period. Although geometric mean MN concentrations differed significantly when adjusted with CS compared with longitudinal models, the estimated prevalence of MN deficiencies in CS and longitudinally adjusted models was similar. CONCLUSIONS: The CF and RC approaches to adjust MN biomarkers for inflammation between individuals in CS surveys are valid approaches for data collection and programmatic decisions in comparable populations. This study was registered at clinicaltrials.gov as NCT00944853.


Assuntos
Ferritinas/sangue , Inflamação/sangue , Micronutrientes/sangue , Estado Nutricional , Projetos de Pesquisa/normas , Proteínas de Ligação ao Retinol/metabolismo , Zinco/sangue , Proteína C-Reativa/metabolismo , Estudos Transversais , Deficiências Nutricionais/sangue , Deficiências Nutricionais/epidemiologia , Feminino , Humanos , Lactente , Estudos Longitudinais , Masculino , Micronutrientes/deficiência , Avaliação Nutricional , Orosomucoide/metabolismo , Prevalência , Reprodutibilidade dos Testes
14.
J Pregnancy ; 2019: 5062365, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30693107

RESUMO

Background: Preterm birth is still a global burden particularly in Indonesia. The suboptimal concentration of certain micronutrients and heavy metals is hypothesized to play a role in the mechanism of preterm birth. Objective: This study aimed to analyze the micronutrients and heavy metals concentrations between subjects with term and preterm birth. Design: A cross-sectional study was conducted during January-June 2017 in Cipto Mangunkusumo Hospital and Budi Kemuliaan Hospital, Jakarta, Indonesia. Subjects were divided into term and preterm birth groups. The measured outcomes were maternal serum, placental, and blood cord concentration of zinc, copper, iron, selenium, manganese, mercury, lead, AtRA, and 25(OH)D. Results: A total of 51 pregnant women participated in this study. Term group had higher concentration of maternal serum AtRA (0.22 ± 0.07 ng/mL versus 0.12 ± 0.03 ng/mL, p <0.001), higher placental concentration of manganese {0.99 (0.38 - 1.78) µg/g versus 0.42 ± 0.18 µg/g, p <0.001}, iron (252.16 ± 170.61 µg/g versus 78.45 ± 51.73 µg/g, p <0.001), copper {2.96 ± 1.80 µg/g versus 1.62 (0.70 - 3.88) µg/g, p 0.019}, zinc {58.34 (27.88 - 124.05) µg/g versus 28.41 (1.46 - 137.69) µg/g, p 0.011}, selenium (0.31 ± 0.31 ng/g versus 0.14 ± 0.20 ng/g, p 0.024), AtRA {21.7 ± 10.69 ng/g versus 0.7 (0.42 - 5.10) ng/g, p <0.001}, and 25(OH)D {75.84 ± 45.12 ng/g versus 18.00 (5 - 88) ng/g, p <0.001}, lower placental concentration of mercury (0.20 ± 0.17 ng/g versus 20.47 ± 41.35 ng/g, p 0.019) and lead (0.02 ± 0.01 ng/g versus 0.81 ± 1.43 ng/g, p 0.009), and higher cord blood concentration of copper {32.20 (16.30 - 69.60) µg/dL versus 20.60 (5.80 - 53.30) µg/dL, p 0.006} and AtRA (0.16 ± 0.04 versus 0.07 ± 0.01, p <0.001). Conclusion: Preterm birth is associated with lower concentrations of micronutrients which play a role in antioxidant mechanism, as well as higher concentration of mercury and lead.


Assuntos
Sangue Fetal/metabolismo , Metais Pesados/sangue , Metais Pesados/metabolismo , Micronutrientes/sangue , Micronutrientes/metabolismo , Placenta/metabolismo , Gravidez/sangue , Gravidez/metabolismo , Nascimento Prematuro/etiologia , Nascimento Prematuro/metabolismo , Antioxidantes , Estudos Transversais , Feminino , Humanos , Indonésia , Chumbo/sangue , Chumbo/metabolismo , Mercúrio/sangue , Mercúrio/metabolismo , Nascimento Prematuro/sangue
15.
J Matern Fetal Neonatal Med ; 32(11): 1755-1761, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29228828

RESUMO

AIM: Profiles of heavy metals such as chromium (Cr), manganese (Mn), arsenic (As), lead (Pb), and cadmium (Cd), and micronutrients such as ferrum (Fe), copper (Cu), zinc (Zn), and selenium (Se) in maternal and umbilical cord blood clots were investigated for assessing placenta function in the transport of micronutrients or heavy metal pollutants. METHODS: Correlations between contents of elements in the two tissues were also analyzed. RESULTS: Significantly lower levels of Cr, Pb, and Cd in umbilical cord blood clots than in maternal blood clots, and negative relationship between lead levels in maternal and umbilical cord blood (r = -.334, p = .016). Concentration of Mn in cord blood was significantly higher than that in maternal blood clots and positively related to the maternal level. The data also show that the placenta may work most strongly as a barrier against Cd and protects fetus from its harmful effect, while plays almost no role in preventing the transportation of As, Mn, and Pb. CONCLUSIONS: In conclusion, pregnant women should avoid exposure to environment polluted with heavy metals, particularly with As, Mn, and Pb.


Assuntos
Sangue Fetal/química , Metais Pesados/sangue , Micronutrientes/sangue , Placenta/química , Gravidez/sangue , Adulto , China , Feminino , Humanos , Adulto Jovem
16.
Metab Syndr Relat Disord ; 17(1): 29-36, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30372368

RESUMO

BACKGROUND: Clinical reference ranges are often used to assess nutritional status, but whether having lower or higher than the current clinical reference range for micronutrients, inflammation, and oxidative stress is related to metabolic syndrome (MetS) is not known. Our objectives are to estimate the odds of having MetS outside of established clinical references, and to identify any effect modifications by sex have for these relationships. METHODS: Data from the 2005 to 2006 National Health and Nutrition Examination Survey were used (≥20 years; N = 2049) with MetS defined utilizing the harmonized criteria from the Joint Interim Statement. The odds of having MetS in individuals with lower or higher than the clinical reference range for the serum concentrations of micronutrient antioxidants, inflammation, and oxidative stress were estimated following adjustments for age, sex, ethnicity, education, income, smoking, alcohol intake, recreational physical activity, and BMI. RESULTS: Having lower than the clinical reference range for carotenoids and vitamin C [odds ratios (95% confidence interval): 1.37 (1.05-1.78) and 1.39 (1.01-1.90), respectively] was associated with significantly greater odds of MetS. By contrast, having higher than the clinical reference range for vitamins A and E, uric acid, and γ-glutamyl transferase (GGT) [2.10 (1.50-2.92), 2.36 (1.78-3.13), 2.65 (1.54-4.57), and 2.08 (1.61-2.69), respectively] was associated with higher odds of MetS, whereas higher levels of vitamins B12 were protective [0.64 (0.42-0.98]. Sex moderated these relationships for carotenoids, vitamin A, C, E, uric acid, C-reactive protein, and GGT. CONCLUSIONS: Lower carotenoids and vitamin C and higher vitamins A and E, uric acid, and oxidative stress were associated with a greater likelihood of MetS, whereas higher vitamin B12 was protective. Further research is necessary to replicate these findings in a prospective setting to confirm the importance of the overall and sex-specific findings.


Assuntos
Inflamação/epidemiologia , Síndrome Metabólica/sangue , Síndrome Metabólica/epidemiologia , Micronutrientes/sangue , Estresse Oxidativo/fisiologia , Adulto , Idoso , Carotenoides/sangue , Estudos Transversais , Feminino , Humanos , Inflamação/sangue , Inflamação/complicações , Masculino , Síndrome Metabólica/complicações , Síndrome Metabólica/metabolismo , Pessoa de Meia-Idade , Inquéritos Nutricionais , Valores de Referência , Estados Unidos/epidemiologia , Vitaminas/sangue
17.
Proc Nutr Soc ; 78(1): 56-67, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30220267

RESUMO

Micronutrients such as trace elements and vitamins are important as enzyme cofactors in the metabolism of all cells in the body and therefore key to determining nutritional status. The present systematic review examined the evidence of the impact of the systemic inflammatory response on plasma micronutrient status in acute (surgical) and chronic tissue injury. A literature review using targeted subject headings was carried out. Plasma C-reactive protein was used to classify minor (80 mg/l) inflammation. The literature search produced 2344 publications and plasma vitamin D, zinc and carotenoids were most commonly studied and plasma vitamins K, B2 and B6 were least studied. In acute injury thirteen studies (all prospective) and in chronic injury twenty-four studies (largely retrospective) were included in the review. There was consistent evidence that most common measured micronutrients in the plasma (zinc, selenium, vitamins A, D, E, K, B2, B6, B12, C, lutein, lycopene, α- and ß-carotene) were significantly lowered from minor to moderate to major inflammation. The results of the present systematic review indicate that most plasma micronutrients fall as part of the systemic inflammatory response irrespective of acute or chronic injury. Therefore, in the presence of a systemic inflammation, plasma micronutrient concentrations should be interpreted with caution. There are a number of methods applied to adjust plasma micronutrient concentrations to avoid misdiagnosis of deficiency. Alternatively, intracellular measurements appear to obviate the need for such plasma adjustment to assess micronutrient status.


Assuntos
Inflamação/sangue , Micronutrientes/sangue , Estado Nutricional , Oligoelementos/sangue , Proteína C-Reativa/análise , Humanos , Estudos Prospectivos , Estudos Retrospectivos
18.
Artigo em Inglês | MEDLINE | ID: mdl-30562990

RESUMO

Cooking with kerosene emits toxic pollutants that may impact pregnancy outcomes. Sixty-eight women in their first trimester of pregnancy, kerosene users (n = 42) and liquefied natural gas (LNG) users (n = 26), were followed until birth. Maternal and cord blood were collected immediately after birth. Levels of micronutrients and heavy metals were quantified. Pregnancy outcomes (gestation age (GA), birth weight (BW), and chest and head circumference) were also measured. Mean (± standard deviation (SD)) age of mothers in kerosene and LNG groups were similar (p = 0.734). Mean (±SD) BW of newborns of LNG users was significantly higher compared to newborns of kerosene users (3.43 ± 0.32 vs. 3.02 ± 0.43, p < 0.001). Mean GA (in weeks) was similar between the two groups (p = 0.532). Women in the kerosene group had significantly higher cord blood levels of zinc, lead, mercury, iodine and vitamin B6 and lower levels of folic acid compared to LNG users (p < 0.05). Newborns of kerosene users had reduced levels of zinc, lead, mercury, iodine, vitamins B6 and B12, folic acid, and homocysteine compared with LNG users (p < 0.05). Also, cooking with kerosene was significantly associated with reduced birth weight after adjusting for potential confounders (ß ± standard error (SE) = -0.326 ± 0.155; p = 0.040). Smoke from kerosene stove was associated with reduced birth weight and micronutrients imbalance in mothers and newborns.


Assuntos
Poluição do Ar em Ambientes Fechados/análise , Culinária/métodos , Metais Pesados/sangue , Micronutrientes/sangue , Resultado da Gravidez/epidemiologia , Adulto , Fatores Etários , Peso ao Nascer , Pesos e Medidas Corporais , Estudos Transversais , Feminino , Sangue Fetal/química , Idade Gestacional , Humanos , Recém-Nascido , Querosene , Mães , Gravidez
19.
Rev Col Bras Cir ; 45(6): e2016, 2018 Dec 10.
Artigo em Português, Inglês | MEDLINE | ID: mdl-30540099

RESUMO

OBJECTIVE: to compare the prevalence of micronutrient deficiencies in patients submitted to sleeve gastrectomy (SG) and Roux- en-Y gastric bypass (RYGB). METHODS: this is a comparative study of 576 patients submitted to bariatric surgery, 338 to SG and 238 to RYGB, and evaluated for hemoglobin, iron, ferritin, zinc and vitamin B12 serum levels. We performed these dosages in the preoperative period and at three, six, 12 and 24 months after surgery, for analysis and comparison of micronutrient deficiencies among the techniques. RESULTS: the SG group consisted of 48 men and 290 women, with a mean BMI of 39.4±2.6kg/m2, and a mean of age of 37.2±11 years; the group RYGB consisted of 77 men and 161 women, with mean BMI 42.7±5.9kg/m2, and a mean age of 41.9±11.1 years. After 24 months, hemoglobin deficiency was present in 24.4% of the patients submitted to SG and in 40% of the RYGB individuals (p=0.054); iron deficiency was present in 6,6% of SG patients and in 15% of RYGB ones (p=0.127); ferritin deficiency occurred in 17.8% of the SG group and in 23.7% of RYGB one (p=0.399); the Zinc deficiency incidence was 6.6% in SG and 30% in RYGB (p=0.002); and B12 deficiency took place in 6.6% the SG patients and in 8.7% of RYGB ones (p=0.844). CONCLUSION: patients undergoing SG had serum levels of iron and zinc superior to the ones undergoing RYGB, the prevalence of the latter micronutrient deficit being significantly higher in the RYGB group.


Assuntos
Gastrectomia/efeitos adversos , Derivação Gástrica/efeitos adversos , Desnutrição/etiologia , Micronutrientes/deficiência , Obesidade Mórbida/cirurgia , Adulto , Brasil/epidemiologia , Feminino , Gastrectomia/métodos , Hemoglobinas/análise , Hemoglobinas/deficiência , Humanos , Masculino , Desnutrição/epidemiologia , Micronutrientes/sangue , Pessoa de Meia-Idade , Período Pós-Operatório , Período Pré-Operatório , Prevalência
20.
Ann Nutr Metab ; 73(4): 290-301, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30368499

RESUMO

Obesity is the most common disease of affluence of the XXI century. According to WHO (World Health Organization), it is defined as a chronic metabolic disorder manifested by excessive accumulation of adipose tissue with high tendency for familial occurrence. According to WHO, obesity reaches epidemic proportions in many countries. High BMI (Body Mass Index) correlates with coexisting diseases. Traditional dietetic treatment often does not bring any results. A form of conservative (non-surgical) support for patients in fighting with obesity is the reduction of stomach volume by bioenteric intragastric balloon (BIB) treatment. The aim of the work was to develop a diet with anti-inflammatory properties, well-tolerated by the patients after BIB treatment. An American diet was modified by changing the composition of fatty acids, increasing anti-oxidative potential and adding synbiotics for patients treated with BIB. Chemical analysis of reconstructed food ratios of recommended diet was performed, analysing the content of micronutrients, composition of fatty acids, antioxidative capacity, reducing power and the content of polyphenols. Improvement in anthropometric measurement results and satisfying body weight loss were obtained, while preserving fat-free body mass. Improvement in the parameters of lipid metabolism was also observed, that is, decrease in total CH (cholesterol) and TG (triglycerides), and normalized concentration of HDL (high density lipoproteins) and LDL (low density lipoproteins) fractions. Reduced concentration of glucose in blood and lower blood pressure was also noted. Performed study confirms the effectiveness of complex treatment with BIB and properly adjusted individualized diet. Observations and own experience allow to deduce that patients who resign from systematic contact with a dietician cannot maintain reduced body weight. Abandoning previous habits is the only way to maintain the effect of weight loss. Most importantly, the change in patients' awareness and consequent behaviour in the future are crucial. Even though genes may contribute to obesity, environmental factors mainly determine the possibility of the disease to occur. Therefore, the change of patients' lifestyle after body weight reduction will decide on their fate.


Assuntos
Dieta/métodos , Balão Gástrico , Obesidade/terapia , Adulto , Anti-Inflamatórios/administração & dosagem , Antioxidantes/administração & dosagem , Composição Corporal , Índice de Massa Corporal , Ácidos Graxos/administração & dosagem , Ácidos Graxos/análise , Humanos , Estilo de Vida , Lipídeos/sangue , Micronutrientes/sangue , Pessoa de Meia-Idade , Obesidade/dietoterapia , Simbióticos/administração & dosagem , Perda de Peso
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA