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1.
Methodist Debakey Cardiovasc J ; 15(3): 179-184, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31687096

RESUMO

Vitamins and minerals are dietary supplements used by almost half of the US adult population based on the presumption that they help prevent or treat cardiovascular disease. Many studies, including randomized trials, have investigated the possible role of these substances in cardiovascular disease. We reviewed the available data on multivitamins/multiminerals, antioxidants, folic acid, vitamin E, niacin (B3), and beta-carotene. Despite extensive investigation, the evidence to date fails to support the use of exogenous supplements of vitamins and minerals for the prevention or treatment of cardiovascular disease. Here, we review some of the common supplements used by adults for cardiovascular health and the available evidence for risks/benefits.


Assuntos
Doenças Cardiovasculares/prevenção & controle , Suplementos Nutricionais , Minerais/uso terapêutico , Serviços Preventivos de Saúde , Vitaminas/uso terapêutico , Doenças Cardiovasculares/diagnóstico , Doenças Cardiovasculares/mortalidade , Suplementos Nutricionais/efeitos adversos , Medicina Baseada em Evidências , Humanos , Minerais/efeitos adversos , Estudos Observacionais como Assunto , Ensaios Clínicos Controlados Aleatórios como Assunto , Fatores de Risco , Resultado do Tratamento , Vitaminas/efeitos adversos
2.
Support Care Cancer ; 27(10): 3997-4010, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31286229

RESUMO

PURPOSE: To update the clinical practice guidelines for the use of natural and miscellaneous agents for the prevention and/or treatment of oral mucositis (OM). METHODS: A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer / International Society of Oral Oncology (MASCC/ISOO). The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. The findings were added to the database used to develop the 2014 MASCC/ISOO clinical practice guidelines. Based on the evidence level, the following guidelines were determined: Recommendation, Suggestion, and No Guideline Possible. RESULTS: A total of 78 papers were identified within the scope of this section, out of which 29 were included in this part, and were analyzed with 27 previously reviewed studies. A new Suggestion was made for oral glutamine for the prevention of OM in head and neck (H&N) cancer patients receiving radiotherapy with concomitant chemotherapy. The previous Recommendation against the use of parenteral glutamine for the prevention of OM in hematopoietic stem cell transplantation (HSCT) patients was re-established. A previous Suggestion for zinc to prevent OM in H&N cancer patients treated with radiotherapy or chemo-radiotherapy was reversed to No Guideline Possible. No guideline was possible for other interventions. CONCLUSIONS: Of the vitamins, minerals, and nutritional supplements studied for the management of OM, the evidence supports a Recommendation against parenteral glutamine in HSCT patients and a Suggestion in favor of oral glutamine in H&N cancer patients for the management of OM.


Assuntos
Glutamina/uso terapêutico , Minerais/uso terapêutico , Mucosite/tratamento farmacológico , Mucosite/prevenção & controle , Estomatite/tratamento farmacológico , Estomatite/prevenção & controle , Vitaminas/uso terapêutico , Suplementos Nutricionais , Glutamina/administração & dosagem , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Neoplasias/tratamento farmacológico
3.
PLoS One ; 14(6): e0218404, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31220118

RESUMO

In an ever-aging society the demand for bone-defect filling grafts continues to gain in importance. While autologous grafting still prevails as the gold standard, allografts and xenografts present viable alternatives with promising results. Physiochemical properties of a graft strongly depend on the processing method such as the decellularization protocol. In addition, the physiochemical characteristics are critical factors for a successful integration of the graft after the implantation and might influence mesenchymal stem cell function in therapeutic approaches combining grafts and autologous mesenchymal stem cells (MSCs). Several decellularization methods have been proposed, however it still remains unclear which method results in favorable physiochemical properties or might be preferred in stem cell applications. In the first part of this study we compared two decellularization approaches resulting in chemically processed allografts (CPAs) or sonication-based processed allografts (SPAs). Each decellularization approach was compared for its decellularization efficacy and its influence on the grafts' surface texture and composition. In the second part of this study biocompatibility of grafts was assessed by testing the effect of extraction medium on MSC viability and comparing them to commercially available allografts and xenografts. Additionally, grafts' performance in terms of MSC functionality was assessed by reseeding with MSCs pre-differentiated in osteogenic medium and determining cell adhesion, proliferation, as well as alkaline phosphatase (ALP) activity and the degree of mineralization. In summary, results indicate a more effective decellularization for the SPA approach in comparison to the CPA approach. Even though SPA extracts induced a decrease in MSC viability, MSC performance after reseeding was comparable to commercially available grafts based on DNA quantification, alkaline phosphatase activity and quantification of mineralization. Commercial Tutoplast allografts showed overall the best effects on MSC functionality as indicated by extraction biocompatibility testing as well as by comparing proliferation and osteogenic differentiation.


Assuntos
Aloenxertos/ultraestrutura , Transplante Ósseo , Fraturas Ósseas/terapia , Transplante de Células-Tronco Mesenquimais , Osteogênese/fisiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Aloenxertos/transplante , Animais , Materiais Biocompatíveis/uso terapêutico , Células da Medula Óssea/ultraestrutura , Bovinos , Destilação , Feminino , Fraturas Ósseas/fisiopatologia , Humanos , Masculino , Células-Tronco Mesenquimais , Microscopia Confocal , Microscopia Eletrônica de Varredura , Pessoa de Meia-Idade , Minerais/uso terapêutico , Sonicação
4.
J Altern Complement Med ; 25(6): 613-622, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31081672

RESUMO

Objectives: There is an increasing body of literature documenting the efficacy of micronutrients (vitamins and minerals) interventions for the treatment of psychiatric problems in the short term; however, long-term safety is largely unexplored. The goal of this observational study was to investigate the safety of two commercially available broad-spectrum micronutrient formulas (EMPowerplus and Daily Essential Nutrients) given at doses above the Recommended Dietary Allowances for the long-term treatment of individuals with psychiatric symptoms. Design: Participants on long-term treatment with micronutrients (medication-free) for psychiatric problems (attention-deficit hyperactivity disorder [ADHD, n = 21], anxiety/depression [n = 13]) were identified from ongoing research studies and the community through purchasing records. Seventeen children and 17 adults had blood tests to assess their full blood count, coagulation profile, liver and kidney function, fasting glucose, iron studies, key nutrients, and prolactin. Questionnaires assessed psychological/psychiatric functioning. Seventeen of the participants had completed the same measures pretreatment. Results: The average length of consuming micronutrients was 2.66 years (standard deviation = 2.86). Excluding B12 (which was elevated for almost all participants), 94.6% of all blood test results were within the test reference ranges. One participant was diagnosed with hemochromatosis based on iron studies. No other clinically relevant adverse changes in blood results were identified pre- and post-treatment. No clinically significant adverse effects were reported. Post-treatment psychometrics identified that 85% of the participants were in nonclinical ranges for measures of ADHD, depression, anxiety, and stress. Conclusions: We report preliminary evidence for the safety of long-term commercially available micronutrients, although questions remain. Overall, the substantial psychiatric benefits observed appear to outweigh the minimal observed risks in these participants. Screening for potential medical problems is recommended before initiating treatment. Long-term pharmacovigilance monitoring is required to ascertain any rare but significant adverse events.


Assuntos
Ansiedade/tratamento farmacológico , Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico , Depressão/tratamento farmacológico , Minerais/efeitos adversos , Oligoelementos/efeitos adversos , Vitaminas/efeitos adversos , Adolescente , Adulto , Transtornos de Ansiedade/tratamento farmacológico , Criança , Transtorno Depressivo/tratamento farmacológico , Feminino , Humanos , Masculino , Micronutrientes/efeitos adversos , Micronutrientes/uso terapêutico , Pessoa de Meia-Idade , Minerais/uso terapêutico , Fatores de Tempo , Oligoelementos/uso terapêutico , Vitaminas/uso terapêutico
5.
J Nutr Sci ; 8: e19, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31143445

RESUMO

Lipid-based nutrient supplements (LNS) may be beneficial for malnourished HIV-infected patients starting antiretroviral therapy (ART). We assessed the effect of adding vitamins and minerals to LNS on body composition and handgrip strength during ART initiation. ART-eligible HIV-infected patients with BMI <18·5 kg/m2 were randomised to LNS or LNS with added high-dose vitamins and minerals (LNS-VM) from referral for ART to 6 weeks post-ART and followed up until 12 weeks. Body composition by bioelectrical impedance analysis (BIA), deuterium (2H) diluted water (D2O) and air displacement plethysmography (ADP), and handgrip strength were determined at baseline and at 6 and 12 weeks post-ART, and effects of LNS-VM v. LNS at 6 and 12 weeks investigated. BIA data were available for 1461, D2O data for 479, ADP data for 498 and handgrip strength data for 1752 patients. Fat mass tended to be lower, and fat-free mass correspondingly higher, by BIA than by ADP or D2O. At 6 weeks post-ART, LNS-VM led to a higher regain of BIA-assessed fat mass (0·4 (95 % CI 0·05, 0·8) kg), but not fat-free mass, and a borderline significant increase in handgrip strength (0·72 (95 % CI -0·03, 1·5) kg). These effects were not sustained at 12 weeks. Similar effects as for BIA were seen using ADP or D2O but no differences reached statistical significance. In conclusion, LNS-VM led to a higher regain of fat mass at 6 weeks and to a borderline significant beneficial effect on handgrip strength. Further research is needed to determine appropriate timing and supplement composition to optimise nutritional interventions in malnourished HIV patients.


Assuntos
Antirretrovirais/efeitos adversos , Composição Corporal/efeitos dos fármacos , Suplementos Nutricionais , Infecções por HIV/complicações , Força da Mão , Adolescente , Adulto , Idoso , Antirretrovirais/uso terapêutico , Índice de Massa Corporal , Contagem de Linfócito CD4 , Deutério , Impedância Elétrica , Feminino , Infecções por HIV/tratamento farmacológico , Humanos , Lipídeos/administração & dosagem , Lipídeos/uso terapêutico , Masculino , Desnutrição/complicações , Desnutrição/dietoterapia , Pessoa de Meia-Idade , Minerais/administração & dosagem , Minerais/uso terapêutico , Pletismografia , Tanzânia , Resultado do Tratamento , Vitaminas/administração & dosagem , Vitaminas/uso terapêutico , Adulto Jovem , Zâmbia
6.
J Altern Complement Med ; 25(6): 567-577, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30912673

RESUMO

Objective: The pathophysiology of atopic dermatitis (AD) involves a complex interplay between immune system dysfunction, genetics, and environmental factors. It is well known that nutritional status is essential to a proper functioning immune system, leading to a highly debated question regarding the role of dietary factors in the pathogenesis of AD. Food allergies and elimination diets have been broadly studied in atopy; however, less consideration has been given to how vitamins, minerals, and other micronutrients influence the risk for AD and severity of symptoms. This systematic review discusses evidence on how various micronutrients, including vitamins (C, E, and D) and trace minerals (zinc, selenium, iron, copper, magnesium, and strontium) are associated with AD, and how supplementation influence disease severity. Design: A systematic search was conducted to identify the role that oral micronutrients have on AD. The authors reviewed 49 studies herein. Results: While there are weak associations between vitamins C or E and AD, there is sufficient evidence to suggest that vitamin D supplementation provides benefit in AD patients. Deficiency of selenium and zinc may exacerbate AD. Current reports are not sufficient to confidently discern the role of other vitamins and trace minerals on AD. Conclusions: Though oral micronutrients may play a role in AD, the current literature is limited, and there is a need for more comprehensive randomized controlled trials (RCTs) to truly decipher the role between oral micronutrients and AD.


Assuntos
Dermatite Atópica/tratamento farmacológico , Suplementos Nutricionais , Minerais/uso terapêutico , Estado Nutricional , Oligoelementos/uso terapêutico , Vitaminas/uso terapêutico , Deficiência de Vitaminas/complicações , Dermatite Atópica/complicações , Humanos , Selênio/uso terapêutico , Índice de Gravidade de Doença , Oligoelementos/deficiência , Vitamina D/uso terapêutico , Zinco/uso terapêutico
7.
Artigo em Inglês | MEDLINE | ID: mdl-30794260

RESUMO

The present case series evaluated three-dimensional volumetric bone tissue changes and new bone formation in severely resorbed extraction sockets augmented with Bio-Oss collagen and a covering collagen membrane in nine chronic periodontitis patients. Healing was by secondary intention. After 12 months of healing, the augmentation procedure appeared not only to compensate for bone remodeling but also appeared to repair a significant portion of the buccal wall. The mineralized tissue filled the 91.49% ± 6.77% of the maximum volume for regeneration. Overall, a mean of 49.6% new bone, 27.1% residual graft material, and 23.3% connective tissue were detected.


Assuntos
Aumento do Rebordo Alveolar/métodos , Periodontite Crônica/cirurgia , Alvéolo Dental/cirurgia , Processo Alveolar/diagnóstico por imagem , Processo Alveolar/patologia , Periodontite Crônica/patologia , Tomografia Computadorizada de Feixe Cônico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Minerais/uso terapêutico , Osteogênese , Radiografia Dentária , Extração Dentária/efeitos adversos , Alvéolo Dental/patologia
8.
Gastrointest Endosc ; 89(4): 865-871, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30612959

RESUMO

BACKGROUND AND AIMS: Acute lower GI bleeding is a frequent cause of hospital admission. The objective of this study was to evaluate the safety and performance of a hemostatic powder (TC-325/Hemospray) in the treatment of nonvariceal lower GI bleeding. METHODS: Patients were enrolled into this prospective, multicenter, single-arm study at 4 tertiary care centers in Canada. Fifty patients with active lower GI bleeding of multiple different causes (52 bleeding sites) underwent topical endoscopic application of hemostatic powder. The primary endpoint was powder-related adverse events within 30 days of the index procedure. Secondary endpoints were initial hemostasis as well as recurrent bleeding and mortality within 30 days of the index procedure. RESULTS: Most patients (96%) had a single bleeding site, and most bleeding (73%) was due to polypectomy. Overall, the powder was applied as monotherapy in 13 bleeding sites (25%), as combination therapy in 22 bleeding sites (42.3%), and as rescue therapy in 17 bleeding sites (32.7%). Hemostasis was achieved in 98% of patients. No patient experienced a powder-related adverse event. Five patients (10%) developed recurrent bleeding within 30 days. One patient (2%) died within 30 days of powder application, but the death was not directly related to hemostatic powder use. CONCLUSIONS: The hemostatic powder is a safe and effective option for patients with lower GI bleeding of varying causes, and in particular, postpolypectomy hemorrhage. The hemostatic powder is effective as monotherapy, part of a combination approach, or as a rescue therapeutic option for the treatment of nonvariceal lower GI bleeding. (Clinical trial registration number: NCT02099435.).


Assuntos
Hemorragia Gastrointestinal/terapia , Hemostase Endoscópica/métodos , Hemostáticos/uso terapêutico , Enteropatias/terapia , Minerais/uso terapêutico , Hemorragia Pós-Operatória/terapia , Adulto , Idoso , Idoso de 80 Anos ou mais , Canadá , Doenças do Ceco/terapia , Doenças do Colo/terapia , Pólipos do Colo/cirurgia , Colonoscopia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Mortalidade , Estudos Prospectivos , Doenças Retais/terapia , Recidiva , Resultado do Tratamento
9.
Gut ; 68(5): 844-853, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-29730601

RESUMO

BACKGROUND: Acute variceal bleeding (AVB) requires early therapeutic management by experienced endoscopists that often poses logistical challenges for hospitals. We assessed a different management concept with early application of haemostatic powder-which does not require high endoscopic expertise-added to conventional management in a randomised trial. METHODS: Cirrhotic patients with AVB received standard medical therapy and were randomised to either immediate endoscopy with haemostatic powder application within 2 hours of admission, followed by early elective endoscopy on the next day, that is, within 12-24 hours of admission for definitive treatment (study group) or to early elective endoscopy only (control group). In both groups, failures to achieve clinical haemostasis until the time of early elective endoscopy underwent rescue endoscopy with attempted conventional haemostasis. Primary outcome was endoscopic haemostasis at the elective endoscopy. RESULTS: Of 86 randomised patients with AVB, 5/43 in the study group required rescue endoscopy for failure of controlling spurting bleeding (n=4) after powder application or for early bleeding recurrence in one patient who died before repeating rescue endoscopy. In the control group, 13/43 patients required rescue endoscopic haemostasis for failure of clinical haemostasis (12%vs30%, p=0.034). In the remaining patients, early elective endoscopic haemostasis was achieved in all 38 patients in the study group, while all remaining 30 patients in the control group had fresh gastric blood or (10%) spurting bleeding at early elective endoscopy with successful haemostasis in all of them. Six-week survival was significantly improved in the study group (7%vs30%, p=0.006). CONCLUSION: The new concept of immediate powder application improves early clinical and endoscopic haemostasis. This simplified endoscopic approach may have an impact on early and 6-week survival. TRIAL REGISTRATION NUMBER: NCT03061604.


Assuntos
Varizes Esofágicas e Gástricas/terapia , Hemorragia Gastrointestinal/terapia , Hemostase Endoscópica/métodos , Hemostáticos/uso terapêutico , Minerais/uso terapêutico , Adulto , Idoso , Esquema de Medicação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pós , Resultado do Tratamento
10.
Artigo em Inglês | MEDLINE | ID: mdl-30543734

RESUMO

The objective of this study was to investigate marginal bone level (MBL) changes as the primary outcome of implants placed following healing of extraction sockets treated with ridge preservation, compared to implants placed following unassisted healing. A total of 268 patients (contributing 572 implants) treated from April 2005 to March 2013 were included in this retrospective study. Following estimation of the overall success rate of implants placed in the practice, 129 patients (contributing 222 implants) met the inclusion and exclusion criteria to be further evaluated. Of these, 78 patients (contributing 105 implants) received ridge preservation procedures, which entailed placement of anorganic bovine bone mineral covered with polytetrafluoroethylene membrane. The other 51 patients (contributing 117 implants), with healed sites without history of bone grafting, served as controls. Digital radiographs were taken at the time of implant placement and during follow-up visits. The mean follow-up period for ridge preservation sites was 33.6 months (range: 7.5 to 61.5 months) and for healed sites was 36.3 months (range: 6 to 91.2 months). The survival rate of implants in sites following healing of ridge preservation was 97.3%, compared to 98.5% in the nongrafted healed sites. The mean MBL changes during the observation period were 0.11 and 0.07 mm on the mesial and 0.06 and 0.06 mm on the distal aspects of the ridge preservation and healed sites, respectively (P > .05). The mean crestal bone remodeling during the observation period was 0.63 and 0.45 mm on the mesial and 0.48 and 0.12 mm on the distal aspects in the ridge preservation and healed sites, respectively (P < .05). The results of this study demonstrated stable MBL and survival of implants placed in sites following ridge preservation with xenograft as well as nongrafted healed sites.


Assuntos
Aumento do Rebordo Alveolar/métodos , Implantação Dentária Endo-Óssea/métodos , Implantes Dentários para Um Único Dente , Minerais/uso terapêutico , Alvéolo Dental/cirurgia , Animais , Bovinos , Feminino , Humanos , Masculino , Membranas Artificiais , Politetrafluoretileno , Estudos Retrospectivos , Resultado do Tratamento
11.
J Craniomaxillofac Surg ; 47(2): 233-238, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30591394

RESUMO

PURPOSE: The aim of the present study was the histomorphometric and cephalometric comparison of autogenous bone grafting of the anterior iliac crest and the application of bovine bone substitute concerning new bone formation and postoperative stability in patients undergoing orthognathic Le Fort I osteotomy. PATIENTS AND METHODS: Twenty-five patients requiring orthognathic surgery with Le Fort I osteotomy were included in this study. Patients were randomly divided into three groups receiving either autogenous iliac crest BONE grafting (BONE; n = 8) or xenogenic bovine bone grafting (Bio-Oss®) in INTER (n = 12) or in ONLAY (n = 5) position. Histomorphometric analysis was performed using trephine bone biopsies from the autogenous, respectively xenogenic bone grafting region. Postoperative stability was evaluated using teleradiographies of three different timepoints. RESULTS: All groups showed comparable mineralized fractions in bone biopsies of 50.2% (±13.2%) INTER, 46.48% (±12.3%) ONLAY and 57.1% (±20.6%) BONE as well as comparable percentage of connective tissue. Patients in the INTER-group revealed the lowest relapse rate of 20.5% (INTER) compared to 30.3% (ONLAY) and 33.0% (BONE). All groups underwent comparable maxillary advancement and healing time. CONCLUSIONS: Present results indicate that block shaped bovine bone substitute is a promising alternative to autogenous bone grafting to bridge the Le Fort I osteotomy gap in orthognathic surgery.


Assuntos
Substitutos Ósseos/uso terapêutico , Transplante Ósseo/métodos , Maxila/cirurgia , Minerais/uso terapêutico , Osteotomia de Le Fort/métodos , Adolescente , Adulto , Animais , Bovinos , Cefalometria , Feminino , Humanos , Ílio/transplante , Masculino , Maxila/patologia , Pessoa de Meia-Idade , Osteogênese , Estudos Prospectivos , Adulto Jovem
12.
Medicine (Baltimore) ; 97(48): e13461, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30508970

RESUMO

RATIONALE: The purpose of this report is to present a case of peri-implantitis with successful regeneration. The surface of the affected dental implant was decontaminated with an ultrasonic scaler and treated with bovine-derived hydroxyapatite and enamel matrix derivative. PATIENT CONCERNS: A 52-year-old male was referred for evaluation of a dental implant placed in the mandibular right second premolar area. DIAGNOSIS: The radiographic evaluation showed the loss of supporting bone around the dental implant. Bleeding upon probing and suppuration were observed, with the deepest probing depth at 6 mm. INTERVENTIONS: The area was firstly treated with a nonsurgical approach. After re-evaluation, a full-thickness flap was elevated. The area was well debrided using various instruments, including curettes and an ultrasonic scaler. The defect area was grafted with bovine-derived hydroxyapatite and enamel matrix derivative. OUTCOMES: Histopathologic evaluation revealed chronic inflammation with fibrosis and calcification. The evaluation at 2 years and 3 months after surgery showed that the prosthesis was functioning well. Bleeding upon probing and suppuration was not noted, and reduction of probing depth was seen, with the deepest depth at 4 mm. The area showed maintenance of graft material with increased radiopacity around the dental implant. LESSONS: In conclusion, a case of peri-implantitis can be successfully treated with bovine-derived hydroxyapatite and enamel matrix derivative after surface decontamination with an ultrasonic scaler.


Assuntos
Matriz Óssea/transplante , Descontaminação/métodos , Esmalte Dentário/transplante , Raspagem Dentária/métodos , Peri-Implantite/terapia , Animais , Produtos Biológicos/uso terapêutico , Regeneração Óssea , Bovinos , Implantes Dentários/efeitos adversos , Humanos , Hidroxiapatitas/uso terapêutico , Masculino , Pessoa de Meia-Idade , Minerais/uso terapêutico , Peri-Implantite/etiologia , Terapia por Ultrassom/métodos
13.
Acta Med Hist Adriat ; 16(2): 283-292, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30488706

RESUMO

AIM: Bitumen is a natural substance effusing from rocks' notches in some highland areas; it has been known as an effective remedy for treating some illnesses. Considering pain relieving properties of bitumen in traditional Persian medicine (TPM) sources, this study aims to review the viewpoints of TPM sages regarding bitumen in the context of traditional Persian medicine. It also provides applicable information for interested researchers to conduct well-designed clinical trials and evaluate therapeutic effects of bitumen claimed in TPM sources. MATERIAL AND METHOD: Various databases including Embase, SID, IRANDOC, IranMedex, Scopus and PubMed were searched with keywords "bitumen" and "Shilajit". Furthermore, main traditional Persian medicine sources including Avicenna's "Canon of medicine", "Continens Liber" by Razes, "The storehouse of medicaments" by Aghili, "Gift for the faithful" by Momen Tonekaboni and "Measure for medicine" written by Muhammad Akbar Shah Arzani were reviewed with Persian keywords "Moomiaii" and "Mumnaei" Results: According to TPM sources, bitumen was used by Iranian's physicians to treat a wide range of diseases. It was known especially as an effective remedy to improve gastrointestinal digestive problems. CONCLUSION: Bitumen is cited in traditional Persian medicine sources as an effective remedy for treatment of a wide range of diseases, especially GI disorders and bone pain. Recent studies showed the beneficial effects of bitumen in treatment of wound healing, however using it in medical practice for other health dilemma should be confirmed by conducting well-designed clinical studies in the future.


Assuntos
Hidrocarbonetos/história , Medicina Tradicional/história , Minerais/história , Resinas Vegetais/história , História Antiga , História Medieval , Humanos , Hidrocarbonetos/uso terapêutico , Irã (Geográfico) , Minerais/uso terapêutico , Pérsia , Resinas Vegetais/uso terapêutico
14.
J Biomed Mater Res A ; 106(12): 3222-3230, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30289606

RESUMO

The aim of this study was to investigate the suppression of inflammation and enhancement of osteogenesis using chitosan-coated calcium hydroxide-loaded microcapsules (CS-EC@Ca microcapsules) in vivo. Circular defects were created in the mandibular bones of rabbits and filled with Ca(OH)2 , Bio-oss, or CS-EC@Ca microcapsules, and rabbits without drug implantation served as the controls. Lipopolysaccharides were injected in situ daily in all groups for 7 days. Mandibular bones were investigated at 4 and 12 weeks after surgery using micro-CT, histological observations, and real-time PCR analysis. At the postoperation, there was more substantial nascent bone in the microcapsule and Bio-oss groups than in the control group. The recovery of the rabbits in the Ca(OH)2 group was slower than the control group, as determined using micro-CT and histological staining. Osteocalcin and collagen type I production was not significantly different between the microcapsule and Bio-oss groups (p > 0.05), but the expression levels of the two molecules were significantly increased compared to the control and Ca(OH)2 groups at postoperation (p < 0.05). The mRNA transcript levels of inflammatory factors in the microcapsule group had the most reduced expression of IL-6 and TNF-α (p < 0.05). The microcapsules significantly reduced inflammation and promoted osteogenesis in this rabbit model of inflammatory bone destruction. Our findings indicate that CS-EC@Ca microcapsules hold potential for use in apical periodontitis treatment. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 3222-3230, 2018.


Assuntos
Substitutos Ósseos/uso terapêutico , Hidróxido de Cálcio/uso terapêutico , Quitosana/uso terapêutico , Inflamação/terapia , Traumatismos Mandibulares/terapia , Minerais/uso terapêutico , Animais , Cimentos para Ossos/uso terapêutico , Cápsulas , Implantes de Medicamento/uso terapêutico , Osteogênese/efeitos dos fármacos , Coelhos
15.
Nutr Hosp ; 35(Spec No6): 60-63, 2018 Sep 07.
Artigo em Espanhol | MEDLINE | ID: mdl-30351164

RESUMO

Metabolic syndrome is the name given to a set of risk factors that increases the risk of cardiovascular disease and other health problems, such as diabetes and stroke. There are different cut-off points to establish the definition of metabolic syndrome according to various international organizations, although in all definitions are considered four main data related to: 1) obesity; 2) alteration of glucose metabolism; 3) alteration of lipid metabolism; and 4) hypertension. Strategies for the treatment of the metabolic syndrome include changes in lifestyle (diet and physical activity), along with pharmacological treatment in certain cases. There is little evidence of the effect of different micronutrients in this syndrome, although there are many investigations in this line.


Assuntos
Deficiência de Vitaminas/complicações , Síndrome Metabólica/complicações , Micronutrientes/administração & dosagem , Minerais/uso terapêutico , Vitaminas/uso terapêutico , Deficiência de Vitaminas/tratamento farmacológico , Humanos , Estilo de Vida , Síndrome Metabólica/tratamento farmacológico , Síndrome Metabólica/terapia , Micronutrientes/uso terapêutico , Fatores de Risco
16.
Periodontol 2000 ; 78(1): 129-153, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30198127

RESUMO

Periodontitis is a complex chronic inflammatory noncommunicable disease, initiated by the development of a dysbiotic microbial plaque biofilm below the gingival margin. Whilst the pathogenic biofilm is a "necessary cause" of periodontitis, it is insufficient on its own to cause the disease, and a destructive immune-inflammatory response is a key to the translation of risk to destructive events. Other exposures or "component causes" include individual genetic predisposition, lifestyle (including smoking and nutrition), and environmental factors. Dietary nutrients are essential for life as they provide crucial energy sources in the form of macronutrients, as well as important cofactors in the form of micronutrients, which regulate the functionality of enzymes during the regulation of anabolic and catabolic processes in human cells. Moreover, micronutrients can regulate gene transcription factors, such as the proinflammatory nuclear factor kappa B and the anti-inflammatory nuclear factor (erythroid-derived 2)-like 2. This review focuses on the role of vitamins (vitamin A, carotenoids, the vitamin B complex, vitamins C, D, and E, and coenzyme Q10) and minerals (calcium, magnesium, iron, zinc, potassium, copper, manganese, and selenium) in human physiology and the impact of their deficiencies upon periodontal health and disease.


Assuntos
Desnutrição/complicações , Micronutrientes/farmacologia , Micronutrientes/uso terapêutico , Doenças Periodontais/tratamento farmacológico , Dieta , Humanos , Minerais/farmacologia , Minerais/uso terapêutico , Nutrigenômica/métodos , Compostos Fitoquímicos/farmacologia , Compostos Fitoquímicos/uso terapêutico , Vitaminas/farmacologia , Vitaminas/uso terapêutico
17.
Nutr. hosp ; 35(n.extr.6): 60-63, sept. 2018. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-181737

RESUMO

El síndrome metabólico es el nombre que se da a un conjunto de factores de riesgo que aumenta el riesgo de enfermedad cardiovascular y otros problemas de salud, como diabetes y accidente cerebrovascular. Existen diferentes puntos de corte para establecer la definición de síndrome metabólico según diversos organismos internacionales, si bien en todas las definiciones se consideran cuatro pilares básicos: 1) obesidad; 2) alteración del metabolismo de la glucosa; 3) alteración del metabolismo de los lípidos; e 4) hipertensión arterial. Las estrategias para el tratamiento del síndrome metabólico incluyen cambios en el estilo de vida (dieta y actividad física) junto con tratamiento farmacológico en determinados casos. Se tiene poca evidencia sobre el efecto de diferentes micronutrientes en dicho síndrome, aunque existen múltiples investigaciones en esta línea


Metabolic syndrome is the name given to a set of risk factors that increases the risk of cardiovascular disease and other health problems, such as diabetes and stroke. There are different cut-off points to establish the definition of metabolic syndrome according to various international organizations, although in all definitions are considered four main data related to: 1) obesity; 2) alteration of glucose metabolism; 3) alteration of lipid metabolism; and 4) hypertension. Strategies for the treatment of the metabolic syndrome include changes in lifestyle (diet and physical activity), along with pharmacological treatment in certain cases. There is little evidence of the effect of different micronutrients in this syndrome, although there are many investigations in this line


Assuntos
Humanos , Deficiência de Vitaminas/complicações , Micronutrientes/administração & dosagem , Minerais/uso terapêutico , Vitaminas/uso terapêutico , Deficiência de Vitaminas/tratamento farmacológico , Estilo de Vida , Síndrome Metabólica/terapia , Micronutrientes/uso terapêutico , Fatores de Risco
18.
Nutr Hosp ; 35(4): 894-902, 2018 Jun 22.
Artigo em Espanhol | MEDLINE | ID: mdl-30070879

RESUMO

INTRODUCTION: adequate nutrition in adolescence is important for growth and development. There are environmental factors that cannot be avoided, such as exposure to heavy metals through natural sources such as water. Arsenic is a metalloid that can cause damage to health (alterations in nutritional status, diabetes, cancer) and it has been found in concentrations higher than those allowed in drinking water. OBJECTIVE: to measure the effect of vitamin and mineral supplementation on the nutritional status and urinary excretion of arsenic in adolescents exposed to this metal through drinking water. MATERIAL AND METHODS: an observational, follow-up study of a cohort was conducted to assess the efficacy of vitamin and mineral supplementation on supplementation in 45 adolescents exposed to arsenic in drinking water, who were given a daily multivitamin supplement for four weeks. Weekly nutritional status and arsenic levels in urine and drinking water were evaluated. RESULTS: the basal nutritional intake was low for proteins, fiber, folic acid, vitamin B2, B6, B12, E, C, selenium and iron, increasing their consumption through the supplement during the intervention and with an increase of approximately 1 g/dl of hemoglobin in all participants. At the end of the intervention, there was an increase in fat-free mass and a decrease in the percentage of body fat. In relation to the urinary excretion of arsenic, the biggest elimination of this metalloid was observed from the first week of intervention (35.91 µg/g Cr [IC 95% = 23.2-74.8 µg/g Cr]), which was statistically significant compared to basal levels of urinary arsenic (43.2 µg/g Cr [IC 95% = 30.8-117.6 µg/g Cr]) (p < 0.05), with an average water consumption with As of 96.2 ± 7.5 µg/l. CONCLUSION: four weeks of supplementation with vitamins and minerals in the adolescent population studied improved nutritional status and increased metalloid excretion significantly in the first and second week after intervention.


Assuntos
Arsênico/urina , Suplementos Nutricionais , Minerais/uso terapêutico , Estado Nutricional , Vitaminas/uso terapêutico , Adolescente , Criança , Estudos de Coortes , Água Potável/análise , Feminino , Seguimentos , Humanos , Masculino
19.
Int J Periodontics Restorative Dent ; 38(Suppl): s29-s35, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30118530

RESUMO

Alveolar ridge preservation is of great importance for successful implant therapy. This study investigated the effects of a xenogeneic tridimensional collagen matrix (CM) in conjunction with deproteinized bovine bone mineral blended with 10% collagen (DBBM-C) on the healing of 12 intact extraction sockets in the esthetic area. Cone beam computed tomograpy examinations revealed nearly stable alveolar ridge dimensions (> 90% of the ridge horizontal dimension was preserved). New bone formation of approximately 45% and adequate resorption of the grafted material were histologically observed. Thus, application of CM together with DBBM-C using minimally invasive flapless approach can preserve the original ridge volume and support bone formation, contributing to adequate bone volume for implant insertion.


Assuntos
Aumento do Rebordo Alveolar/métodos , Substitutos Ósseos/uso terapêutico , Colágeno/uso terapêutico , Minerais/uso terapêutico , Processo Alveolar/diagnóstico por imagem , Processo Alveolar/patologia , Animais , Bovinos , Tomografia Computadorizada de Feixe Cônico , Estética Dentária , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Osteogênese , Projetos Piloto
20.
Nutr. hosp ; 35(4): 894-902, jul.-ago. 2018. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-179883

RESUMO

Introducción: la adecuada nutrición en la adolescencia es de importancia para el crecimiento y desarrollo. Existen factores ambientales que no pueden evitarse, como la exposición a metales pesados a través de fuentes naturales como el agua. El arsénico es un metaloide que puede causar un daño a la salud (alteraciones del estado nutricio, diabetes, cáncer) y ha sido encontrado en concentraciones superiores a las permitidas en el agua de consumo. Objetivo: medir el efecto de una suplementación de vitaminas y minerales sobre el estado nutricio y la excreción urinaria de arsénico en adolescentes expuestos a este metal a través de agua de consumo. Material y métodos: se realizó un estudio de intervención y longitudinal para la valorar la eficacia de la suplementación de vitaminas y minerales sobre la suplementación en 45 adolescentes, expuestos a arsénico en agua de consumo, a quienes se dio un suplemento multivitamínico diariamente durante cuatro semanas. De forma semanal se evaluaron el estado nutricio y los niveles de arsénico en orina y en agua de consumo. Resultados: en la población de estudio se observó que el consumo nutrimental basal fue bajo para proteínas, fibra, ácido fólico, vitamina B2, B6, B12, E, C, selenio y hierro, incrementando su consumo a través del suplemento durante la intervención y con un aumento de aproximadamente 1 g/dl de hemoglobina en todos los participantes. Al final de la intervención presentaron incremento de masa libre de grasa y disminución en el porcentaje de grasa corporal. Por otro lado, en cuanto a la excreción urinaria de arsénico, se observó mayor eliminación de este metal (35,91 μg/g Cr [IC 95% = 23,2-74,8 μg/g Cr]) desde la primera semana de intervención, la cual fue estadísticamente significativa en comparación con los niveles basales de arsénico urinario (43,2 μg/g Cr [IC 95% = 30,8-117,6 μg/g Cr]) (p < 0,05), con un consumo promedio de agua con As de 96,2 ± 7,5 μg/l. Conclusión: la suplementación con vitaminas y minerales de cuatro semanas en la población de adolescentes estudiada mejoró el estado nutricio y aumentó la excreción del metaloide de manera significativa en la primera y segunda semana postintervención


Introduction: adequate nutrition in adolescence is important for growth and development. There are environmental factors that cannot be avoided, such as exposure to heavy metals through natural sources such as water. Arsenic is a metalloid that can cause damage to health (alterations in nutritional status, diabetes, cancer) and it has been found in concentrations higher than those allowed in drinking water. Objective: to measure the effect of vitamin and mineral supplementation on the nutritional status and urinary excretion of arsenic in adolescents exposed to this metal through drinking water. Material and methods: an observational, follow-up study of a cohort was conducted to assess the efficacy of vitamin and mineral supplementation on supplementation in 45 adolescents exposed to arsenic in drinking water, who were given a daily multivitamin supplement for four weeks. Weekly nutritional status and arsenic levels in urine and drinking water were evaluated. Results: the basal nutritional intake was low for proteins, fiber, folic acid, vitamin B2, B6, B12, E, C, selenium and iron, increasing their consumption through the supplement during the intervention and with an increase of approximately 1 g/dl of hemoglobin in all participants. At the end of the intervention, there was an increase in fat-free mass and a decrease in the percentage of body fat. In relation to the urinary excretion of arsenic, the biggest elimination of this metalloid was observed from the first week of intervention (35.91 μg/g Cr [IC 95% = 23.2-74.8 μg/g Cr]), which was statistically significant compared to basal levels of urinary arsenic (43.2 μg/g Cr [IC 95% = 30.8-117.6 μg/g Cr]) (p < 0.05), with an average water consumption with As of 96.2 ± 7.5 μg/l. Conclusion: four weeks of supplementation with vitamins and minerals in the adolescent population studied improved nutritional status and increased metalloid excretion significantly in the first and second week after intervention


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Arsênico/urina , Suplementos Nutricionais , Minerais/uso terapêutico , Estado Nutricional , Vitaminas/uso terapêutico , Água Potável/análise , Seguimentos , Estudos de Coortes , Estudo Observacional
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