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1.
BMJ Case Rep ; 16(1)2023 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-36599490

RESUMO

Oral soft-tissue myxomas of the oral cavity have been sparsely cited in the medical literature worldwide. This could be due to other clinically and/or histologically similar lesions requiring accurate differential diagnosis by experienced physicians and pathologists. Although myxomas are benign and do not metastasise, they have higher rates of recurrence and deserve proper attention and to be reported as well. Soft-tissue myxomas of the oral cavity are extremely rare and very few cases have been reported in the literature. The article describes a soft-tissue myxoma in a male patient in his 40s and review of published cases.


Assuntos
Boca , Mixoma , Humanos , Masculino , Boca/patologia , Mixoma/diagnóstico por imagem , Mixoma/cirurgia
2.
Lasers Med Sci ; 38(1): 38, 2023 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-36630018

RESUMO

It was to report a rare case of peripheral odontogenic myxoma removed with high-power diode laser and to do an extensive review of studies of odontogenic cysts and tumors treated with high-power laser (HPL). This is a rare case of a 63-year-old male patient with a peripheral odontogenic myxoma measuring approximately 10 cm in the attached gingiva region of tooth 16 removed with a high-power diode laser (808 nm, 3 W, in continuous mode, under constant suction, with 400-µm optical fiber). A literature review was also carried out looking for articles that involved the use of HPL in the treatment of odontogenic cysts and tumors, without restriction of year or language. In the present case, there was no need for suturing, no postoperative discomfort, and minimal bleeding during the procedure. In a 12-month follow-up period, there were no signs of recurrence. Only two cases of intra-osseous odontogenic myxomas treated with HPL and 10 cases involving other odontogenic cysts and tumors were found. All studies showing HPL to be effective in treating these lesions. Despite the different types of lasers used and different parameters, it is observed that lasers are effective in the treatment of odontogenic lesions.


Assuntos
Mixoma , Tumores Odontogênicos , Masculino , Humanos , Pessoa de Meia-Idade , Lasers Semicondutores/uso terapêutico , Mixoma/cirurgia , Mixoma/diagnóstico , Mixoma/patologia , Tumores Odontogênicos/radioterapia , Tumores Odontogênicos/cirurgia , Tumores Odontogênicos/diagnóstico
3.
In Vivo ; 37(1): 503-505, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36593012

RESUMO

BACKGROUND/AIM: Superficial angiomyxoma (SAM) is a rare benign soft-tissue tumor that usually occurs in the trunk, head and neck, and lower extremity of middle-aged adults. Herein, we describe an unusual case of SAM of the wrist, which was initially diagnosed as a ganglion cyst on imaging. CASE REPORT: The patient was a 71-year-old man with no history of trauma who presented with a 2-year history of a palpable mass in the left wrist. Physical examination revealed a 2.5-cm, elastic hard, mobile, nontender mass. Magnetic resonance imaging revealed a well-defined mass with iso-signal intensity relative to skeletal muscle on T1-weighted sequences and very high signal intensity on T2-weighted fat-suppressed sequences. Subtle internal enhancement was seen following gadolinium administration. Complete excision was performed under general anesthesia with tourniquet control. Histologically, the lesion was composed of bland spindle to stellate-shaped cells in an abundant myxoid stroma. Immunohistochemically, the lesional cells were positive for CD34 but negative for S-100 protein, smooth-muscle actin, desmin, epithelial membrane antigen and pancytokeratin. These findings were consistent with a diagnosis of SAM. There was no clinical evidence of recurrence during a follow-up period of 3 months. CONCLUSION: Although extremely rare, SAM should be considered in the differential diagnosis of a cyst-like solid lesion near small joints.


Assuntos
Mixoma , Neoplasias de Tecidos Moles , Masculino , Pessoa de Meia-Idade , Adulto , Humanos , Idoso , Punho/patologia , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/cirurgia , Neoplasias de Tecidos Moles/patologia , Diagnóstico Diferencial , Mixoma/diagnóstico , Mixoma/cirurgia , Mixoma/metabolismo , Imageamento por Ressonância Magnética
4.
J Neurol Sci ; 444: 120517, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36528975

RESUMO

BACKGROUND: Cardiac myxoma (CM) is an important etiology of stroke in young adults, but studies on CM-related ischemic stroke (CM-IS) are limited and conflicting. Hence, we investigated clinical characterizations, risk factors of CM-IS, and short-term survival after surgical resection. METHODS: We performed a retrospective analysis of data from all CM patients at three referral management centers and conducted follow-up examination. RESULTS: Among 414 CM patients, 402 were recruited for further analysis, including 54 patients with CM-IS and 348 patients with CM without stroke (Non-stroke). In the acute phase, patients presented with NIHSS 3 (interquartile range: 0-10) and clinical presentation comprising neurological, cardiac and constitutional symptoms. Multivariate analysis showed that the factors associated with an increased risk of CM-IS were tumor width < 30 mm [OR = 2.652, 95% CI: 1.061-6.627, P = 0.037], tumors with high-mobility (OR = 2.700, 95% CI: 1.357-5.371, P = 0.005), thrombus on the tumor surface (OR = 1.856, 95% CI: 1.003-3.434, P = 0.049), and lower B-type natriuretic peptide (BNP) levels (OR = 0.995, 95% CI: 0.989-0.999, P = 0.047). The overall three-year survival rate was 95.7% (95% CI: 94.9-96.5) in CM-IS patients who underwent surgery. CONCLUSIONS: CM-IS patients had mild or moderate neurologic deficits with various presentations at disease onset. Narrower tumor width, tumors with high-mobility, thrombus on the tumor surface, and lower BNP levels are potential predictors of CM-IS development. Surgical removal of CM is safe and efficacious in patients with CM-IS.


Assuntos
AVC Isquêmico , Mixoma , Acidente Vascular Cerebral , Trombose , Adulto Jovem , Humanos , Estudos Retrospectivos , Estudos de Casos e Controles , Peptídeo Natriurético Encefálico , Acidente Vascular Cerebral/etiologia , Acidente Vascular Cerebral/cirurgia , Acidente Vascular Cerebral/diagnóstico , Fatores de Risco , Mixoma/complicações , Mixoma/cirurgia , Mixoma/patologia , Trombose/complicações
5.
Anticancer Res ; 42(12): 6121-6125, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36456122

RESUMO

BACKGROUND/AIM: Carney complex (CNC) is a rare autosomal dominant tumor-predisposition syndrome with variable expression. Its main features are pigmentary skin lesions, soft-tissue myxomas, and endocrine overactivity or tumors. There is occasional overlap with other syndromes, and oligosymptomatic cases may escape diagnosis. This report describes the long journey of a patient until the diagnosis of CNC was finally made after a thorough diagnostic workup. CASE REPORT: The female patient was referred for treatment of a subcutaneous tumor of the lower abdomen. Medical reports detailed previous excisions of fibroma, neurofibroma and myxoma, and a malignant tumor of the cerebellopontine angle. The resected subcutaneous tumor was a myxoma. The identification of a previously unknown frameshift mutation in the gene for protein kinase cAMP-dependent type I regulatory subunit alpha (PRKAR1A) in the patient confirmed the diagnosis of CNC. CONCLUSION: Patients with CNC may have highly variable clinical findings. Some rare lesions in CNC are more commonly recorded in other syndromes, making early diagnosis difficult in some cases. Genetic testing greatly facilitates diagnosis.


Assuntos
Complexo de Carney , Mixoma , Humanos , Feminino , Complexo de Carney/diagnóstico , Complexo de Carney/genética , Síndrome , Fatores de Transcrição , Mixoma/diagnóstico , Mixoma/genética , Mixoma/cirurgia , Mutação , Subunidade RIalfa da Proteína Quinase Dependente de AMP Cíclico/genética
6.
BMC Cardiovasc Disord ; 22(1): 576, 2022 12 30.
Artigo em Inglês | MEDLINE | ID: mdl-36585613

RESUMO

BACKGROUND: Atrial myxomas account for approximately 50% of all primary cardiac tumors. The size, location, risk of embolic event, and involvement of other cardiac structures, are all factors that contribute to the wide range of presentation for cardiac myxomas. Patients with myxomas may remain asymptomatic, while others may report symptoms such as fatigue and fever, dyspnea, and syncope. It is important to recognize arrhythmias as an uncommon symptom of myxomas. CASE PRESENTATION: We report a rare case of a 67-year-old man who presented with pre-syncopal episodes, symptomatic bradycardia, and night sweats found to have a 5.5 × 5.1 × 3 cm myxoma in the left atrium. During diastole the mass caused dynamic flow obstruction across the mitral valve. The patient underwent surgical resection of the mass given his symptomatology and risk of embolic events. Removal of the myxoma resulted in resolution of both pre-syncopal episodes and the patient's sinus bradycardia. CONCLUSION: Atrial myxomas are a rare cause of pre-syncope and symptomatic bradycardia. It is important to have a clinical suspicion for atrial myxomas given early diagnosis and surgical intervention are key in improving the prognosis of these patients. This case also highlights the importance of taking into account the source of the myxoma's blood supply in relationship to other cardiac structures, and further correlating these findings with clinical symptoms.


Assuntos
Fibrilação Atrial , Neoplasias Cardíacas , Mixoma , Masculino , Humanos , Idoso , Bradicardia/diagnóstico , Bradicardia/etiologia , Fibrilação Atrial/complicações , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/cirurgia , Neoplasias Cardíacas/complicações , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/cirurgia , Síncope/etiologia , Mixoma/complicações , Mixoma/diagnóstico por imagem , Mixoma/cirurgia
7.
Medicine (Baltimore) ; 101(46): e31617, 2022 Nov 18.
Artigo em Inglês | MEDLINE | ID: mdl-36401457

RESUMO

RATIONALE: Aggressive angiomyxoma (AAM) is a rare mesenchymal tumor primarily involving the lower genital tract of reproductive females. It often shares pathologic morphology with other mesenchymal lesions, which result in diagnostic difficulties for pathologists. PATIENT CONCERNS AND DIAGNOSES: We described the case of a 32-year-old female presenting with a pelvic mass. Imaging examination showed a "swirling sign" within the mass. The mass was 10.2 × 10 × 7.7 cm, located in the right front of the uterus, with unclear demarcation from the surrounding organs and tissues. The gross appearance was grayish brown with a solid section and a myxedematous cut surface. Microscopically, it was a mesenchymal tumor with a presence of perivascular smooth muscle fibers radiating from the blood vessel and an infiltrative growth pattern. The pelvic AAM was diagnosed based on clinicopathologic and imaging features. INTERVENTIONS AND OUTCOMES: A surgery with local excision of the mass was performed. The patient experienced 1 relapse during 2-year follow-up and underwent the radiation therapy. LESSONS: When the pathological morphology of AAM overlaps with other mesenchymal lesions, the comprehensive understanding of tumor clinicopathological characteristics combined with imaging features is important for the accurate diagnosis of AAM.


Assuntos
Mixoma , Recidiva Local de Neoplasia , Humanos , Feminino , Adulto , Mixoma/diagnóstico , Mixoma/cirurgia , Mixoma/patologia , Pelve/patologia
8.
Ann Ital Chir ; 93: 562-565, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36353852

RESUMO

BACKGROUND: Aggressive angiomyxoma is a type of mesenchymal tumor occurring predominantly in the pelvic and perineal region. The aim of our study was to reveal our experience with gonadotropin-releasing hormone (GnRH) treatment in patients with angiomyxoma and provide a comprehensive review of management. PATIENTS AND METHODS: This study is a case-series including seven female patients diagnosed with aggressive angiomyxoma from a single institution, between 2012 and 2020. Follow-up after surgery was ranged between 2-45 months with an average of 17.6 months. Resection was performed in all patients without any complications, and five had received GnRH analogue (Goserelin acetate) therapy after surgery. Immunohistochemistry analyses showed positivity for smooth muscle actin and desmin in all cases, while both estrogen receptor (ER) and progesterone receptor (PR) positivity were identified in 6 patients. None of the seven patients had recurrence during follow up period. CONCLUSION: The mean treatment of aggressive angiomyxoma is surgery, and the use of GnHR analogues in cases with positive ER and PR may be effective in preventing recurrence. KEY WORDS: Aggressive Angiomyxoma, Gonadotropin-Releasing Hormone, Soft Tissue Neoplasm.


Assuntos
Mixoma , Humanos , Feminino , Mixoma/diagnóstico , Mixoma/cirurgia , Receptores de Estrogênio , Imuno-Histoquímica , Períneo/cirurgia , Períneo/patologia , Hormônio Liberador de Gonadotropina
9.
Georgian Med News ; (330): 40-42, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36427839

RESUMO

Intramuscular myxoma (IM) is a benign, soft tissue neoplasm of mesenchymal origin. IM is rare, with an incidence of between 0.1 and 0.13 in every 100,000 individuals. Onset is usually between the fourth and seventh decades of life, predominantly in women (70%). The thigh is the common site of involvement seen in 51% patients, followed by upper arm (9%), calf (7%), and rarely in buttocks. We present the case of a 63-year-old female patient with a 6-month history of a growing IM of the right buttock. Due to rapid tumor growth resection of the tumor was indicated to obtain histopathological examination and to rule out malignancy. Marginal surgical removal was performed. Histopathological examination brought the diagnosis of a big intramuscular myxoma. There is no recurrence at latest follow-up.


Assuntos
Mixoma , Neoplasias de Tecidos Moles , Humanos , Feminino , Pessoa de Meia-Idade , Nádegas/cirurgia , Mixoma/diagnóstico por imagem , Mixoma/cirurgia , Neoplasias de Tecidos Moles/diagnóstico por imagem , Neoplasias de Tecidos Moles/cirurgia
12.
Kardiologiia ; 62(9): 74-78, 2022 Sep 30.
Artigo em Russo | MEDLINE | ID: mdl-36206141

RESUMO

This article presents a clinical case of urgent, life-saving surgical intervention in a 69-year-old woman with left atrial myxoma with rapid morphological and clinical progression and a history of COVID-19 and breast cancer in remission. However, the concurrent (perhaps secondary) thrombophilic condition facilitated the complication development in the form of superior vena caval orifice thrombosis in the early postoperative period. For this complication, repeated surgery in the volume of thrombectomy was performed, which resulted in stabilization of the patient's condition.


Assuntos
COVID-19 , Neoplasias Cardíacas , Mixoma , Idoso , COVID-19/complicações , Feminino , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/patologia , Neoplasias Cardíacas/complicações , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas/cirurgia , Humanos , Mixoma/complicações , Mixoma/diagnóstico , Mixoma/cirurgia , Trombectomia/métodos , Veia Cava Superior/patologia
13.
J Cardiothorac Surg ; 17(1): 261, 2022 Oct 08.
Artigo em Inglês | MEDLINE | ID: mdl-36209231

RESUMO

Post-Acute COVID-19 syndrome (PACS) is considered to be one of the least understood post-infectious syndromes. We report a case of a 21-year-old female who had a history of SARS-CoV-2 infection and presented with a right atrioventricular thrombus associated with pulmonary embolism and thrombocytopenia. At the time of admission, she was not vaccinated against SARS-CoV-2, and her serological tests for IgG and IgM antibodies against SARS-CoV-2 were positive. The size of the thrombus measured approximately 6 × 8 × 4 cm, which also led to tricuspid valve insufficiency due to mechanical dilatation of the valve's ring. The right atrioventricular thrombus also extended up to the inferior vena cava, leading to mild congestive hepatomegaly. Moreover, during thrombectomy, the mass of the thrombus was attached to the interseptal right atrial wall. The histopathological assessment of the core mass revealed that it was a right atrial myxoma hidden inside that large thrombus. We suspect that the formation and propagation of the thrombus to that size occurs as a part of Post-Acute COVID-19 syndrome (PACS). This study reviews and discusses coronavirus disease 2019-relate to thrombus formation inside cardiac chambers in case of a cardiac tumor, like myxoma in the setting of post-acute phase COVID-19 syndrome.


Assuntos
COVID-19 , Neoplasias Cardíacas , Mixoma , Trombose , Adulto , COVID-19/complicações , Feminino , Átrios do Coração/patologia , Neoplasias Cardíacas/complicações , Humanos , Imunoglobulina G , Imunoglobulina M , Mixoma/complicações , Mixoma/diagnóstico , Mixoma/cirurgia , SARS-CoV-2 , Trombose/complicações , Veia Cava Inferior , Adulto Jovem
15.
J Clin Ultrasound ; 50(9): 1268-1270, 2022 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-36215199

RESUMO

Although several studies have shown that myocardial contrast echocardiography and 18-FDG PET/CT can differentiate between benign and malignant intracardiac masses, it is rarely used in practice to evaluate myxoma. This case describes the contrast echocardiography and 18-FDG PET/CT findings of a giant myxoma with an atypical location and subclinical symptoms.


Assuntos
Neoplasias Cardíacas , Mixoma , Humanos , Fluordesoxiglucose F18 , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos , Tomografia Computadorizada por Raios X/métodos , Mixoma/diagnóstico por imagem , Mixoma/cirurgia , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/cirurgia , Ecocardiografia
16.
J Cardiothorac Surg ; 17(1): 258, 2022 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-36203203

RESUMO

BACKGROUND: Cardiac myxoma is the most common benign cardiac tumor. Its tremendous size and fragile character severely bother the surgeons. Several minimal invasive approaches had been applied for radical tumor excision. The wound was forcibly enlarged for en-bloc specimen removal and prevention of debris sputtering. CASE PRESENTATION: We reported a case of huge tricuspid valve (TV) myxoma managed by robot-assisted endoscopic tumor resection and TV repair, with initial presentation of worsening shortness of breath for two months. The tumor was downsized with a morcellator and removed through a keyhole wound (1.1 cm in diameter). The patient recovered uneventfully and was discharged after four days. CONCLUSIONS: With the first morcellator application, this might be the smallest surgical wound reported after the removal of a huge cardiac myxoma. The ICU and hospital stays were shortened. This might be effectively applied to further minimally invasive surgeries for cardiac tumor excision.


Assuntos
Neoplasias Cardíacas , Mixoma , Robótica , Endoscopia , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/cirurgia , Humanos , Mixoma/diagnóstico por imagem , Mixoma/cirurgia , Valva Tricúspide/cirurgia
17.
World J Pediatr Congenit Heart Surg ; 13(6): 770-776, 2022 11.
Artigo em Inglês | MEDLINE | ID: mdl-36300271

RESUMO

Myxomas are rare tumors in neonates and tend to have a different presentation compared to adults. We present an infant with a left atrial myxoma presenting with episodic tachycardia who underwent successful surgical excision. In addition, we performed a review of the literature, identifying 17 cases of neonatal myxomas. Unlike adults, neonatal myxomas are more common in males and occur more often on the right side of the heart. Constitutional symptoms such as fever or embolism are rare among neonates. Most patients have favorable outcomes following surgical excision, refuting earlier claims that neonatal myxomas are associated with poor outcomes.


Assuntos
Embolia , Neoplasias Cardíacas , Mixoma , Adulto , Masculino , Recém-Nascido , Humanos , Mixoma/diagnóstico por imagem , Mixoma/cirurgia , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/cirurgia , Febre , Coração , Átrios do Coração/cirurgia , Átrios do Coração/patologia
19.
Artigo em Inglês | MEDLINE | ID: mdl-36232202

RESUMO

Myxomas are slowly growing benign neoplasms which are rare in children. Up to 80% can be located in the left atrium and generate symptoms such as embolism, cardiac failure, fever and weight loss. Rarely, myxomas can be detected in the right ventricle outflow tract, causing arrhythmias, pulmonary emboli and sudden death. We report the case of a 13-year-old healthy child brought to the Emergency Department (ED) of the Children's Hospital Bambino Gesù, Rome, for recent dyspnea, chest pain on exertion and new onset cardiac murmur. Patient underwent medical examination and echocardiogram with the finding of a rounded and lobulated voluminous mass in the right ventricle outflow tract (RVOT) which caused severe obstruction. The contrast computed tomography (CT) scan confirmed the presence of a heterogeneously enhancing soft-tissue mass occupying the RVOT with no evidence of pulmonary embolization. The mass was surgically excised, and the pathologic examination confirmed our suspicion of myxoma. Our experience suggests that myxoma can have mild clinical symptoms, the presentation may be non-specific, and diagnosis can be a challenge Careful examination and a diagnostic imaging workup, primarily with the transthoracic echocardiogram, are needful to make a rapid differential diagnosis and to better manage surgical treatment and follow-up.


Assuntos
Neoplasias Cardíacas , Mixoma , Adolescente , Criança , Dispneia/etiologia , Sopros Cardíacos/etiologia , Sopros Cardíacos/patologia , Neoplasias Cardíacas/complicações , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas/cirurgia , Ventrículos do Coração , Humanos , Mixoma/complicações , Mixoma/diagnóstico , Mixoma/cirurgia
20.
F1000Res ; 11: 986, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36250001

RESUMO

Primary cardiac tumors (PCTs) are extremely rare entities. More than half of PCTs are benign, with myxoma being the most common tumor. Generally, simple tumor resection is the treatment of choice for benign PCTs since it has promising results that yield low complication and recurrence rates. However, in the COVID-19 pandemic era, the mitigation protocols and/or concurrent COVID-19 infection should be taken into account in patient management for the best overall outcome. To our knowledge, this is the first case report of a patient with a left atrial myxoma and systemic embolism complication in the form of an ischemic stroke, with a concurrent confirmed COVID-19 delta variant infection.


Assuntos
COVID-19 , Neoplasias Cardíacas , Mixoma , COVID-19/complicações , Átrios do Coração/patologia , Átrios do Coração/cirurgia , Neoplasias Cardíacas/complicações , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/cirurgia , Humanos , Mixoma/complicações , Mixoma/patologia , Mixoma/cirurgia , Pandemias , SARS-CoV-2
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