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1.
BMJ Case Rep ; 14(2)2021 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-33526532

RESUMO

Polyangiitis overlap syndrome (POS) is a diagnostic term coined by Leavitt and Fauci that characterises patients with overlapping features of more than one vasculitis. Prior case studies of antineutrophil cytoplasmic antibodies (ANCA)-associated POS have only been published in patients with eosinophilic granulomatosis with polyangiitis (EGPA) and granulomatosis with polyangiitis alongside proteinase-3/cytoplasmic (C)-ANCA positivity. We present a case of a 60-year-old woman with dyspnoea, hemoptysis, positive perinuclear-ANCA and renal biopsy demonstrating evidence of microscopic polyangiitis. In addition, our patient also had asthma, mononeuritis multiplex, eosinophilia and migratory pulmonary infiltrates, thus fulfilling the criteria for EGPA. This novel case report suggests that POS is not limited to C-ANCA positivity and has variable presentations.


Assuntos
Síndrome de Churg-Strauss/diagnóstico , Doenças Pulmonares Intersticiais/diagnóstico por imagem , Poliangiite Microscópica/diagnóstico , Mononeuropatias/fisiopatologia , Insuficiência Renal Crônica/fisiopatologia , Anticorpos Anticitoplasma de Neutrófilos/imunologia , Azatioprina/uso terapêutico , Síndrome de Churg-Strauss/tratamento farmacológico , Síndrome de Churg-Strauss/imunologia , Síndrome de Churg-Strauss/fisiopatologia , Ciclofosfamida/uso terapêutico , Feminino , Humanos , Imunossupressores/uso terapêutico , Poliangiite Microscópica/tratamento farmacológico , Poliangiite Microscópica/imunologia , Poliangiite Microscópica/fisiopatologia , Pessoa de Meia-Idade , Peroxidase/imunologia , Prednisona/uso terapêutico , Insuficiência Renal Crônica/patologia , Tomografia Computadorizada por Raios X
2.
Arthritis Rheumatol ; 72(1): 67-77, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31390162

RESUMO

OBJECTIVE: To determine the frequency, clinical characteristics, associations, and outcomes of different types of peripheral nervous system (PNS) disease in a multiethnic/multiracial, prospective inception cohort of systemic lupus erythematosus (SLE) patients. METHODS: Patients were evaluated annually for 19 neuropsychiatric (NP) events including 7 types of PNS disease. SLE disease activity, organ damage, autoantibodies, and patient and physician assessment of outcome were measured. Time to event and linear regressions were used as appropriate. RESULTS: Of 1,827 SLE patients, 88.8% were female, and 48.8% were white. The mean ± SD age was 35.1 ± 13.3 years, disease duration at enrollment was 5.6 ± 4.2 months, and follow-up was 7.6 ± 4.6 years. There were 161 PNS events in 139 (7.6%) of 1,827 patients. The predominant events were peripheral neuropathy (66 of 161 [41.0%]), mononeuropathy (44 of 161 [27.3%]), and cranial neuropathy (39 of 161 [24.2%]), and the majority were attributed to SLE. Multivariate Cox regressions suggested longer time to resolution in patients with a history of neuropathy, older age at SLE diagnosis, higher SLE Disease Activity Index 2000 scores, and for peripheral neuropathy versus other neuropathies. Neuropathy was associated with significantly lower Short Form 36 (SF-36) physical and mental component summary scores versus no NP events. According to physician assessment, the majority of neuropathies resolved or improved over time, which was associated with improvements in SF-36 summary scores for peripheral neuropathy and mononeuropathy. CONCLUSION: PNS disease is an important component of total NPSLE and has a significant negative impact on health-related quality of life. The outcome is favorable for most patients, but our findings indicate that several factors are associated with longer time to resolution.


Assuntos
Doenças dos Nervos Cranianos/fisiopatologia , Lúpus Eritematoso Sistêmico/fisiopatologia , Vasculite Associada ao Lúpus do Sistema Nervoso Central/fisiopatologia , Doenças do Sistema Nervoso Periférico/fisiopatologia , Adulto , Fatores Etários , Estudos de Coortes , Doenças dos Nervos Cranianos/etiologia , Feminino , Humanos , Lúpus Eritematoso Sistêmico/complicações , Masculino , Pessoa de Meia-Idade , Mononeuropatias/etiologia , Mononeuropatias/fisiopatologia , Análise Multivariada , Doenças do Sistema Nervoso Periférico/etiologia , Modelos de Riscos Proporcionais , Índice de Gravidade de Doença , Adulto Jovem
3.
J Vet Dent ; 36(1): 8-16, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31138049

RESUMO

Trigeminal nerve pathology can lead to sensory and motor dysfunction to structures of the head that are easily recognized. The trigeminal nerve is a conduit for the distribution of postganglionic parasympathetic innervation to structures of the head. Parasympathetic innervation to the salivary glands is provided by preganglionic parasympathetic neurons of the facial and glossopharyngeal nerves. Postganglionic axons course with branches of the mandibular branch of the trigeminal nerve to reach the salivary glands. Denervation of the salivary glands impacts glandular function, leading to a reduction in the volume and composition of the saliva produced. Saliva plays an important role in oral health. Poor oral health has widespread systemic implications. This article describes a group of dogs with unilateral or bilateral dysfunction of the trigeminal nerve and/or its branches. In all dogs, an accumulation of thick, foamy saliva was observed accumulating in the dorsal aspect of the caudal oral cavity on the ipsilateral side to the affected nerve. In dogs with magnetic resonance imaging (MRI), there was a reduction in size based on the largest cross-sectional area measurement and an increase in mean signal intensity of the salivary glands ipsilateral to the affected nerves compared to the glands on the normal side. The authors hypothesize that the abnormal saliva and MRI changes observed were consequent to parasympathetic denervation of the salivary glands. The recognition of this clinical observation is the first step in understanding the impact that denervation has on salivation and ultimately on overall oral and systemic health in dogs.


Assuntos
Doenças do Cão/fisiopatologia , Mononeuropatias/veterinária , Glândulas Salivares/anormalidades , Doenças do Nervo Trigêmeo/veterinária , Nervo Trigêmeo/fisiopatologia , Animais , Doenças do Cão/etiologia , Cães , Feminino , Masculino , Mononeuropatias/etiologia , Mononeuropatias/fisiopatologia , Salivação/fisiologia , Doenças do Nervo Trigêmeo/etiologia , Doenças do Nervo Trigêmeo/fisiopatologia
5.
Sci Rep ; 7: 45930, 2017 04 05.
Artigo em Inglês | MEDLINE | ID: mdl-28378856

RESUMO

The present study was performed to explore the role of galanin and galanin receptor 2 in nociceptive modulation in anterior cingulate cortex (ACC) of normal rats and rats with mononeuropathy. Intra-ACC injection of galanin induced significant increases in hindpaw withdrawal latencies (HWLs) to thermal and mechanical stimulations in both normal rats and rats with mononeuropathy, the increased HWLs were attenuated significantly by intra-ACC injection of galanin receptor 2 antagonist M871, indicating an involvement of galanin receptor 2 in nociceptive modulation in ACC. Interestingly, the galanin-induced HWL was significant higher in rats with mononeuropathy than that in normal rats tested by Randall Selitto test. Furthermore, both the galanin mRNA expression and galanin content increased significantly in ACC in rats with mononeuropathy than that in normal rats. Moreover, both the mRNA levels of galanin receptor 2 and the content of galanin receptor 2 in ACC increased significantly in rats with mononeuropathy than that in normal rats. These results found that galanin induced antinociception in ACC in both normal rats and rats with mononeuropathy. And there may be plastic changes in the expression of galanin and galanin receptor 2 in rats with mononeuropathy, as well as in the galanin-induced antinociception.


Assuntos
Galanina/metabolismo , Giro do Cíngulo/metabolismo , Mononeuropatias/metabolismo , Nociceptores/metabolismo , Precursores de Proteínas/metabolismo , Receptor Tipo 2 de Galanina/metabolismo , Animais , Galanina/genética , Galanina/farmacologia , Expressão Gênica/efeitos dos fármacos , Giro do Cíngulo/efeitos dos fármacos , Giro do Cíngulo/fisiopatologia , Membro Posterior , Masculino , Mononeuropatias/genética , Mononeuropatias/fisiopatologia , Nociceptividade/efeitos dos fármacos , Dor Nociceptiva/genética , Dor Nociceptiva/metabolismo , Dor Nociceptiva/fisiopatologia , Nociceptores/efeitos dos fármacos , Medição da Dor/métodos , Peptídeos/farmacologia , Precursores de Proteínas/genética , Precursores de Proteínas/farmacologia , Ratos Sprague-Dawley , Receptor Tipo 2 de Galanina/antagonistas & inibidores , Receptor Tipo 2 de Galanina/genética
6.
Rheumatology (Oxford) ; 56(suppl_1): i14-i23, 2017 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-27744358

RESUMO

Neurological and psychiatric syndromes, collectively referred to as NPSLE, occur frequently in SLE. The frequency of NPSLE varies from 21 to 95%; however, only 13-38% of neuropsychiatric (NP) events could be attributable to SLE in the NPSLE SLICC inception cohort. This variability in the frequency of NPSLE is attributable to the low specificity of the ACR case definitions for SLE-attributed NP syndromes, inclusion of minor NP events in the ACR nomenclature, difficulty in ascertainment of NP events and diverse experience of rheumatologists in the clinical assessment of NP events. Making the correct and early attribution of NP events to SLE is important to institute appropriate immunosuppressive treatment for favourable outcomes. Various attribution models using composite decision rules have been developed and used to ascribe NP events to SLE. This review will focus on the various clinical presentations, diagnostic work-up and attributions of the common NPSLE syndromes, including other NP events not included in the ACR nomenclature but which have come to attention in recent years.


Assuntos
Vasculite Associada ao Lúpus do Sistema Nervoso Central/diagnóstico , Transtornos de Ansiedade/diagnóstico , Transtornos de Ansiedade/etiologia , Transtornos de Ansiedade/fisiopatologia , Transtornos de Ansiedade/psicologia , Transtornos Cerebrovasculares/diagnóstico , Transtornos Cerebrovasculares/etiologia , Transtornos Cerebrovasculares/fisiopatologia , Disfunção Cognitiva/diagnóstico , Disfunção Cognitiva/etiologia , Disfunção Cognitiva/fisiopatologia , Disfunção Cognitiva/psicologia , Doenças dos Nervos Cranianos/diagnóstico , Doenças dos Nervos Cranianos/etiologia , Doenças dos Nervos Cranianos/fisiopatologia , Diagnóstico Diferencial , Epilepsia/diagnóstico , Epilepsia/etiologia , Epilepsia/fisiopatologia , Humanos , Lúpus Eritematoso Sistêmico/complicações , Lúpus Eritematoso Sistêmico/fisiopatologia , Lúpus Eritematoso Sistêmico/psicologia , Vasculite Associada ao Lúpus do Sistema Nervoso Central/etiologia , Vasculite Associada ao Lúpus do Sistema Nervoso Central/fisiopatologia , Vasculite Associada ao Lúpus do Sistema Nervoso Central/psicologia , Meningite Asséptica/diagnóstico , Meningite Asséptica/etiologia , Meningite Asséptica/fisiopatologia , Mononeuropatias/diagnóstico , Mononeuropatias/etiologia , Mononeuropatias/fisiopatologia , Transtornos do Humor/diagnóstico , Transtornos do Humor/etiologia , Transtornos do Humor/fisiopatologia , Transtornos do Humor/psicologia , Neuromielite Óptica/diagnóstico , Polineuropatias/diagnóstico , Polineuropatias/etiologia , Polineuropatias/fisiopatologia , Síndrome da Leucoencefalopatia Posterior/diagnóstico , Transtornos Psicóticos/diagnóstico , Transtornos Psicóticos/etiologia , Transtornos Psicóticos/fisiopatologia , Transtornos Psicóticos/psicologia , Doenças da Medula Espinal/diagnóstico , Doenças da Medula Espinal/etiologia , Doenças da Medula Espinal/fisiopatologia
7.
Pflugers Arch ; 468(11-12): 2017-2030, 2016 11.
Artigo em Inglês | MEDLINE | ID: mdl-27726011

RESUMO

The superficial dorsal horn contains large numbers of interneurons which process afferent and descending information to generate the spinal nociceptive message. Here, we set out to evaluate whether adjustments in patterns and/or temporal correlation of spontaneous discharges of these neurons are involved in the generation of central sensitization caused by peripheral nerve damage. Multielectrode arrays were used to record from discrete groups of such neurons in slices from control or nerve damaged mice. Whole-cell recordings of individual neurons were also obtained. A large proportion of neurons recorded extracellularly showed well-defined patterns of spontaneous firing. Clock-like neurons (CL) showed regular discharges at ∼6 Hz and represented 9 % of the sample in control animals. They showed a tonic-firing pattern to direct current injection and depolarized membrane potentials. Irregular fast-burst neurons (IFB) produced short-lasting high-frequency bursts (2-5 spikes at ∼100 Hz) at irregular intervals and represented 25 % of the sample. They showed bursting behavior upon direct current injection. Of the pairs of neurons recorded, 10 % showed correlated firing. Correlated pairs always included an IFB neuron. After nerve damage, the mean spontaneous firing frequency was unchanged, but the proportion of CL increased significantly (18 %) and many of these neurons appeared to acquire a novel low-threshold A-fiber input. Similarly, the percentage of IFB neurons was unaltered, but synchronous firing was increased to 22 % of the pairs studied. These changes may contribute to transform spinal processing of nociceptive inputs following peripheral nerve damage. The specific roles that these neurons may play are discussed.


Assuntos
Potenciais de Ação , Mononeuropatias/fisiopatologia , Nociceptividade , Células do Corno Posterior/fisiologia , Animais , Células Cultivadas , Feminino , Camundongos
8.
Intern Med ; 55(18): 2717-22, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27629974

RESUMO

A patient with xerostomia and xerophthalmia due to Sjögren's syndrome presented with acute motor-dominant polyneuropathy and multiple mononeuropathy with antiganglioside antibodies. Nerve conduction studies and a sural nerve biopsy revealed the neuropathy as a mixture of segmental demyelination and axonal degeneration. Positive results were obtained for several antiganglioside antibodies. Corticosteroid treatment proved effective. The neuropathy was considered to represent a mixture of polyneuropathy as Guillain-Barré syndrome and multiple mononeuropathy via Sjögren's syndrome. We speculate that Guillain-Barré syndrome occurred in the patient and Guillain-Barré syndrome itself activated multiple mononeuropathy via Sjögren's syndrome.


Assuntos
Síndrome de Guillain-Barré/fisiopatologia , Mononeuropatias/fisiopatologia , Síndrome de Sjogren/fisiopatologia , Síndrome de Guillain-Barré/complicações , Síndrome de Guillain-Barré/imunologia , Humanos , Masculino , Pessoa de Meia-Idade , Mononeuropatias/complicações , Mononeuropatias/imunologia , Condução Nervosa/fisiologia , Síndrome de Sjogren/complicações , Síndrome de Sjogren/imunologia , Xerostomia/complicações
9.
Neurol Neurochir Pol ; 50(6): 474-480, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27471096

RESUMO

Diabetes is a common disorder that leads to the musculoskeletal symptoms such as the shoulder arthritis. The involvement of peripheral nervous system is one of the troublesome for the patients as it provokes chronic sensory symptoms, lower motor neuron involvement and autonomic symptoms. In the course of the disease there has been several types of neuropathies described. A 41-year-old male patient was admitted to the internal medicine department because of the general weakness, malaise, polydypsia and polyuria since several days. The initial blood glucose level was 780mg/dl. During the first day the continuous insulin infusion was administered. On the next day when he woke up, the severe pain in the right shoulder with limited movement, right upper extremity weakness and burning pain in the radial aspect of this extremity appeared. On examination right shoulder joint movement limitation was found with the muscle weakness and sensory symptoms in the upper limbs. The clinical picture indicated on the right shoulder arthritis and the peripheral nervous system symptoms such as the right musculocutaneous, supraspinatus, right radial nerve and left radial nerve damage. We present a first case report of simultaneous, acute involvement of the shoulder joint and multiple neuropathy in a patient with newly diagnosed type 2 diabetes, presumably in the state of ketoacidosis.


Assuntos
Artrite/complicações , Bursite/complicações , Diabetes Mellitus Tipo 2/complicações , Cetoacidose Diabética/complicações , Mononeuropatias/complicações , Neuropatia Radial/complicações , Adulto , Artrite/diagnóstico por imagem , Bursite/diagnóstico por imagem , Diabetes Mellitus Tipo 2/diagnóstico , Humanos , Imagem por Ressonância Magnética , Masculino , Mononeuropatias/diagnóstico , Mononeuropatias/fisiopatologia , Debilidade Muscular/complicações , Debilidade Muscular/fisiopatologia , Nervo Musculocutâneo/fisiopatologia , Condução Nervosa , Dor/complicações , Neuropatia Radial/diagnóstico , Neuropatia Radial/fisiopatologia , Amplitude de Movimento Articular , Articulação do Ombro/diagnóstico por imagem , Articulação do Ombro/fisiopatologia
11.
Clin Neurophysiol ; 127(1): 880-885, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-25998202

RESUMO

OBJECTIVE: The objective of this study was to investigate the usefulness of muscle ultrasound for evaluating muscle changes caused by denervation in carpal tunnel syndrome (CTS), which is a focal neuropathy. METHODS: The mean and standard deviation (SD) of echo intensity (EI) in the thenar and hypothenar muscles were calculated in 35 patients with CTS and 11 healthy subjects. Patients were assigned to three subgroups based on CTS severity as determined by electrodiagnostic tests. The ratio of thenar muscle pixel brightness to hypothenar muscle pixel brightness was used in statistical analyses. The ratio of mean pixel brightness was termed the EI ratio, and the ratio of the SD of pixel brightness was termed the inhomogeneity ratio. RESULTS: Both the EI ratio and the inhomogeneity ratio were significantly higher in the patient group than in the control group. In a comparison of the three patient subgroups, the severe group showed significant differences in both the EI and inhomogeneity ratios compared to the other two groups. Subjects with denervation potential in the abductor pollicis brevis (APB) had higher EI and inhomogeneity ratios than subjects without denervation potential in the APB. CONCLUSION: The EI ratio and inhomogeneity ratio are useful variables with which to evaluate disease severity and the presence of denervation in patients with CTS. SIGNIFICANCE: Muscle ultrasound has clinical significance in the detection of muscle changes that result from neuropathy.


Assuntos
Síndrome do Túnel Carpal/diagnóstico por imagem , Nervo Mediano/diagnóstico por imagem , Mononeuropatias/diagnóstico por imagem , Músculo Esquelético/diagnóstico por imagem , Nervo Ulnar/diagnóstico por imagem , Adulto , Idoso , Síndrome do Túnel Carpal/fisiopatologia , Eletromiografia/métodos , Feminino , Humanos , Masculino , Nervo Mediano/fisiopatologia , Pessoa de Meia-Idade , Mononeuropatias/fisiopatologia , Músculo Esquelético/fisiopatologia , Nervo Ulnar/fisiopatologia , Ultrassonografia
12.
Artigo em Russo | MEDLINE | ID: mdl-26525809

RESUMO

OBJECTIVE: To evaluate the efficacy and tolerability of axamon (ipidacrine) therapy in patients with focal neuropathies--mononeuropathies. MATERIAL AND METHODS: We examined 35 patients, aged 18 years and older, with focal neuropathies (tunnel syndromes, radiculopathies). In the main group (n=20) axamon (ipidacrine) was prescribed in addition to the basic (standard) therapy (group B vitamins, lipoic acid) during 6 week, in the control group (n=15) patients remained only on the basic (standard) treatment. RESULTS: In the main group positive clinical changes were accompanied by the more significant positive electroneuromyographic (ENMG) dynamics as compared to the control group (the increased amplitude of M-response in the muscles of the hand and feet; increased nerve conduction velocity in the peripheral nerves as a manifestation of remyelination activity, and others). CONCLUSION: The obtained clinical and ENMG data indicate that axamon (ipidacrine) is a unique cholinesterase inhibitor with conduction action primarily targeting on efferent (motor) fibers of the peripheral nerves.


Assuntos
Aminoquinolinas/uso terapêutico , Inibidores da Colinesterase/uso terapêutico , Mononeuropatias/tratamento farmacológico , Quimioterapia Combinada , Eletromiografia , Feminino , Humanos , Masculino , Mononeuropatias/fisiopatologia , Músculo Esquelético/fisiopatologia , Ácido Tióctico/uso terapêutico , Complexo Vitamínico B/uso terapêutico
13.
Anesth Analg ; 121(1): 229-38, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26039418

RESUMO

BACKGROUND: Mononeuropathies (MNs: nerve ligation) and polyneuropathies (PNs: cisplatin) produce unilateral and bilateral tactile allodynia, respectively. We examined the effects of intraplantar (IPLT) and intrathecal (IT) botulinum toxin B (BoNT-B) on this allodynia. METHODS: Mice (male c57Bl/6) were prepared with an L5 nerve ligation. Others received cisplatin (IP 2.3 mg/kg/d, every other day for 6 injections). Saline and BoNT-B were administered through the IPLT or IT route. We examined mechanical allodynia (von Frey hairs) before and at intervals after BoNT. As a control, we injected IPLT BoNT-B treated with dithiothreitol to cleave heavy chain from light chain. We measured motor function using acute thermal escape and sensorimotor tests. RESULTS: MN and PN mice showed a persistent ipsilateral and bilateral allodynia, respectively. IPLT BoNT-B resulted in an ipsilateral dorsal horn reduction in the synaptic protein target of BoNT-B (vesicle-associated membrane protein) and a long-lasting (up to approximately 17 days) reversal of allodynia in PN and MN models. The predominant effect after IPLT delivery was ipsilateral to IPLT BoNT. The effects of IPLT BoNT-B in MN mice were blocked by prior reduction of BoNT-B with dithiothreitol. IT BoNT-B in mice with PN resulted in a bilateral reversal of allodynia. With these dosing parameters, hind paw placing and stepping reflexes were unaltered, and there were no changes in thermal escape latencies. After cisplatin, dorsal root ganglions displayed increases in activation transcription factor 3, which were reduced by IT, but not IPLT BoNT-B. CONCLUSIONS: BoNT-B given IPLT and IT yields a long-lasting attenuation of the allodynia in mice displaying MN and PN allodynia.


Assuntos
Analgésicos/administração & dosagem , Toxinas Botulínicas Tipo A/administração & dosagem , Hiperalgesia/tratamento farmacológico , Mononeuropatias/tratamento farmacológico , Neuralgia/tratamento farmacológico , Limiar da Dor/efeitos dos fármacos , Polineuropatias/tratamento farmacológico , Fator 3 Ativador da Transcrição/metabolismo , Animais , Comportamento Animal/efeitos dos fármacos , Modelos Animais de Doenças , Hiperalgesia/metabolismo , Hiperalgesia/fisiopatologia , Hiperalgesia/psicologia , Injeções Espinhais , Injeções Subcutâneas , Masculino , Camundongos Endogâmicos C57BL , Mononeuropatias/metabolismo , Mononeuropatias/fisiopatologia , Mononeuropatias/psicologia , Atividade Motora/efeitos dos fármacos , Neuralgia/metabolismo , Neuralgia/fisiopatologia , Neuralgia/psicologia , Medição da Dor , Estimulação Física , Polineuropatias/metabolismo , Polineuropatias/fisiopatologia , Polineuropatias/psicologia , Células do Corno Posterior/efeitos dos fármacos , Células do Corno Posterior/metabolismo , Tempo de Reação/efeitos dos fármacos , Fatores de Tempo , Proteínas de Transporte Vesicular/metabolismo
14.
Neurosci Lett ; 599: 129-32, 2015 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-26022629

RESUMO

Calcium/calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine- dependent protein kinase, which has been implicated in pain modulation at different levels of the central nervous system. The present study was performed in rats with mononeuropathy induced by left common sciatic nerve ligation. Unilateral sciatic nerve loose ligation produced decreases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation. Intra-nucleus accumbens (NAc) injection of 3 µg, 6 µg and 12 µg of myristoylated autocamtide-2-inhibitory peptide (AIP), the CaMKII inhibitor, dose-dependently increased the HWL to noxious thermal and mechanical stimulation in rats with mononeuropathy. Furthermore, intra-NAc administration of morphine, the HWL to noxious thermal and mechanical stimulation increased markedly, and there were no significant differences between morphine group and AIP group. Taken together, the results showed that intra-NAc injection of AIP induced significant antinociceptive effects in rats with mononeuropathy, indicating that CaMKII may play an important role in the transmission and/or modulation of nociceptive information in the NAc in rats with mononeuropathy.


Assuntos
Analgésicos/uso terapêutico , Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo , Mononeuropatias/tratamento farmacológico , Núcleo Accumbens/efeitos dos fármacos , Peptídeos/uso terapêutico , Animais , Temperatura Alta , Masculino , Mononeuropatias/metabolismo , Mononeuropatias/fisiopatologia , Morfina/uso terapêutico , Núcleo Accumbens/metabolismo , Estimulação Física , Ratos Sprague-Dawley , Nervo Isquiático/lesões , Tato
15.
Int J Mol Sci ; 16(3): 4642-65, 2015 Mar 02.
Artigo em Inglês | MEDLINE | ID: mdl-25739080

RESUMO

Wallerian degeneration or nerve demyelination, arising from spinal nerve compression, is thought to bring on chronic neuropathic pain. The widely distributed metabotropic glutamate receptor subtype 5 (mGluR5) is involved in modulating nociceptive transmission. The purpose of this study was to investigate the potential effects of mGluR5 on peripheral hypersensitivities after chronic constriction injury (CCI). Sprague-Dawley rats were operated on with four loose ligatures around the sciatic nerve to induce thermal hyperalgesia and mechanical allodynia. Primary afferents in dermis after CCI exhibited progressive decreases, defined as partial cutaneous denervation; importantly, mGluR5 expressions in primary afferents were statistically increased. CCI-induced neuropathic pain behaviors through the intraplantar injections of 2-methyl-6-(phenylethynyl)-pyridine (MPEP), a selective mGluR5 antagonist, were dose-dependently attenuated. Furthermore, the most increased mGluR5 expressions in primary afferents surrounded by reactive Schwann cells were observed at the distal CCI stumps of sciatic nerves. In conclusion, these results suggest that nerve demyelination results in the increases of mGluR5 expression in injured primary afferents after CCI; and further suggest that mGluR5 represents a main therapeutic target in developing pharmacological strategies to prevent peripheral hypersensitivities.


Assuntos
Doenças Desmielinizantes/metabolismo , Mononeuropatias/metabolismo , Neuralgia/metabolismo , Receptor de Glutamato Metabotrópico 5/metabolismo , Animais , Doenças Desmielinizantes/fisiopatologia , Derme/inervação , Derme/metabolismo , Antagonistas de Aminoácidos Excitatórios/farmacologia , Hiperalgesia/diagnóstico , Hiperalgesia/metabolismo , Hiperalgesia/fisiopatologia , Imuno-Histoquímica , Masculino , Microscopia de Fluorescência , Mononeuropatias/fisiopatologia , Fibras Nervosas/química , Neuralgia/fisiopatologia , Proteínas de Neurofilamentos/metabolismo , Medição da Dor , Piridinas/farmacologia , Ratos Sprague-Dawley , Receptor de Glutamato Metabotrópico 5/antagonistas & inibidores , Nervo Isquiático/lesões , Nervo Isquiático/metabolismo , Nervo Isquiático/fisiopatologia
16.
Clin Neurol Neurosurg ; 131: 5-10, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25655301

RESUMO

INTRODUCTION: Leprosy causes nerve injury, which mimics clinical and neurophysiological conditions, rendering it an excellent model of peripheral neuropathy. METHODS: A retrospective study including 822 nerve conduction studies (NCS) of 509 patients was developed to appraise the electrophysiological pattern of leprosy neuropathy. NCS of motor and sensory nerves performed before, during, and after multidrug therapy (MDT) were analyzed. RESULTS: During the three periods of MDT, while NCS alterations were similar regarding extension, topography, damage severity, and type of lesion, NCS showed that sensory was more frequent (sural nerve) (92-96%) than motor impairment (70-77%) (ulnar nerve). CONCLUSION: Once axonal loss has been installed, nerve function is little affected by inflammatory, immune and/or bacterial events since chronic neuropathy has been established, inevitably leading to the well-known leprosy sequelae occurring at any time before and/or after leprosy diagnosis.


Assuntos
Hanseníase/complicações , Condução Nervosa/fisiologia , Doenças do Sistema Nervoso Periférico/etiologia , Doenças do Sistema Nervoso Periférico/fisiopatologia , Adolescente , Adulto , Idoso , Criança , Feminino , Humanos , Hanseníase/imunologia , Masculino , Pessoa de Meia-Idade , Mononeuropatias/fisiopatologia , Nervo Sural/fisiopatologia , Neuropatias Ulnares/fisiopatologia , Adulto Jovem
17.
J Back Musculoskelet Rehabil ; 28(4): 883-5, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25547236

RESUMO

Most cases of scapular winging (SW) are attributed to either long thoracic or spinal accessory nerve lesions. Dorsal scapular nerve lesions are quite rare and the literature contains very few case reports of SW secondary to rhomboid paralysis. We are reporting the unusual case of a young patient who developed right-side scapular winging due to dorsal scapular neuropathy and rhomboids palsy, and we highlight the role of conservative treatment and rehabilitation for cases of mild/medium injury to the dorsal scapular nerve or to the rhomboid muscles. For those cases, physiotherapy is recommended, and this is mainly aimed at strengthening the trapezius in order to compensate for rhomboids weakness.


Assuntos
Mononeuropatias/etiologia , Músculo Esquelético/inervação , Paralisia/etiologia , Escápula/inervação , Nervos Torácicos/lesões , Adulto , Eletromiografia , Humanos , Masculino , Mononeuropatias/fisiopatologia , Mononeuropatias/reabilitação , Paralisia/fisiopatologia , Paralisia/reabilitação , Modalidades de Fisioterapia
18.
Neurosci Lett ; 583: 6-10, 2014 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-25218714

RESUMO

The present study was conducted on rats with mononeuropathy induced by left common sciatic nerve ligation. Unilateral sciatic nerve loose ligation produced decreases of the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation. Intra-nucleus accumbens (NAc) injection of 1µg, 3µg and 6µg of KN93, the calcium/calmodulin-dependent protein kinase II (CaMKII) inhibitor, dose-dependently increased the HWL in mononeuropathic rats. Furthermore, intra-NAc administration of morphine, the HWL to noxious thermal and mechanical stimulation increased markedly, and there were no significant differences between morphine group and KN93 group. The results demonstrated that intra-NAc injection of KN93 induced significant antinociceptive effects in rats with mononeuropathy, indicating CaMKII may play important roles in transmission of nociceptive information in the NAc of mononeuropathic rats.


Assuntos
Analgésicos/farmacologia , Benzilaminas/farmacologia , Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/antagonistas & inibidores , Mononeuropatias/fisiopatologia , Núcleo Accumbens/efeitos dos fármacos , Sulfonamidas/farmacologia , Analgésicos/uso terapêutico , Animais , Temperatura Alta , Hiperalgesia/fisiopatologia , Masculino , Morfina/farmacologia , Núcleo Accumbens/metabolismo , Estimulação Física , Ratos Sprague-Dawley , Nervo Isquiático/lesões
19.
An. vet. Murcia ; 29: 93-110, ene.-dic. 2013. ilus
Artigo em Espanhol | IBECS | ID: ibc-129498

RESUMO

La región selar y paraselar (SPS) contiene formaciones óseas, vasculares, nervios somáticos y autónomos, la hipófisis y las estructuras meníngeas relacionadas que la convierte en asiento de diversas patologías neurológicas, oftalmológicas o endocrinológicas. El objetivo de este trabajo es describir la anatomía de la región SPS y comunicar un cuadro clínico observado en un perro y en 2 gatos consistente en una mononeuropatía múltiple que involucra diversos NC en su recorrido en relación a esta región que, por sus características, constituye un síndrome particular. En nuestro conocimiento esta es la primera descripción de un síndrome que afecte a perros y gatos y que pueda comprometer simultáneamente uno o más de los NC II, III, IV, los 3 nervios que forman el V (oftálmico, maxilar y mandibular) y VI, a la glándula hipófisis y sus cubiertas meníngeas, y al tronco encefálico (diencéfalo) (AU)


The sellar and parasellar region (SPS) contains bone structures, vascular structures, somatic and autonomous nerves, the pituitary gland and meningeal structures related that predisposes to various neurological, ophthalmologic or endocrine diseases The aim of this work is to describe the anatomy of the SPS region and communicate a clinical picture observed in a dog and 2 cats consisting of a multiple mononeuropathy involving various cranial nerves on their way in relation to this region and, by its nature, is particularly syndrome. To our knowledge this is the first description of a syndrome affecting dogs and cats and can simultaneously engage one or more of the II, III, IV, V (ophthalmic, maxillary and mandibular nerves) and VI cranial nerves, the pituitary gland and its meningeal coverings, and the brain and brain stem (AU)


Assuntos
Animais , Masculino , Feminino , Gatos , Cães , Mononeuropatias/complicações , Mononeuropatias/fisiopatologia , Mononeuropatias/veterinária , Sela Túrcica/anatomia & histologia , Seios Paranasais/anatomia & histologia , Nervos Cranianos/anatomia & histologia , Toxoplasma/patogenicidade , Membrana Nictitante/anatomia & histologia , Membrana Nictitante/patologia , Estrabismo/patologia , Midríase/patologia , Doenças do Sistema Nervoso Periférico/complicações , Doenças do Sistema Nervoso Periférico/veterinária
20.
J Am Acad Orthop Surg ; 21(11): 675-84, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24187037

RESUMO

Tendon transfers are used to restore balance and function to a paralyzed, injured, or absent neuromuscular-motor unit. In general, tendon transfer is indicated for restoration of muscle function after peripheral nerve injury, injury to the brachial plexus or spinal cord, or irreparable injury to tendon or muscle. The goal is to improve the balance of a neurologically impaired hand. In the upper extremity, tendon transfers are most commonly used to restore function following injury to the radial, median, and ulnar nerves. An understanding of the general principles of tendon transfer is important to maximize the outcome.


Assuntos
Mononeuropatias/cirurgia , Transferência Tendinosa/métodos , Humanos , Neuropatia Mediana/cirurgia , Mononeuropatias/fisiopatologia , Força Muscular , Neuropatia Radial/cirurgia , Técnicas de Sutura , Polegar/fisiopatologia , Neuropatias Ulnares/cirurgia
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