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1.
J Assoc Physicians India ; 69(6): 11-12, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34472787

RESUMO

BACKGROUND: The present study intended to estimate the comorbidities and risk factors among patients with hypertension in India. Further, the current practice of hypertension management was evaluated and the choice of therapy was assessed based on hypertension grade, risk factors, and comorbidities. METHODS: Electronic medical record data (June 2017-June 2019) of Indian adult hypertensive patients (≥140/90 mmHg) who had two blood pressure (BP) readings were retrospectively analyzed. Demographic characteristics, BP readings, comorbidities, medications and co-medications, and laboratory data were collected at baseline. Grids based on hypertension grade (I, II, and III), demographic factors, risk factors, and comorbidities were created and prescribed antihypertensive drugs (AHDs) in each grid were evaluated. RESULTS: Among 100,075 patients, the proportion of patients in 18-40 year, 40-65 year, and >65 year age groups were 11.4%, 65.1%, and 23.4%, respectively. Proportion of men and women was similar (52.0% vs 47.9%). Proportion of patients with BMI <25 Kg/m2 was 8.1%, 25-29.9 Kg/m2 was 11.9%, and >30 Kg/m2 was 8.8%. Mean BP of patients with hypertension was: grade I (145.05/90.73 mmHg), grade II (160.07/95.64 mmHg), and grade III (180.82/102.76 mmHg). Mean low density lipoprotein (113.26 mg/dL), serum creatinine (2.28 mg/dL), mean HbA1c (8.7%) levels were highest among patients with grade III hypertension. Commonly observed comorbidities were type 2 diabetes mellitus (T2DM: 51.5%), dyslipidemia (36.4%), and chronic kidney disease (CKD: 4.4%). Top concomitant medications included anti-diabetic therapies (34.6%), drugs for dyslipidemia (30.0%), and anti-platelet therapies (6.9%). CONCLUSION: Most prescribed AHD monotherapies were angiotensin receptor II blockers (ARBs) and calcium channel blockers (CCBs) and most prescribed combination therapies were ARBs + diuretics and ARBs + CCBs. Telmisartan and amlodipine+telmisartan for patients with comorbid T2DM or dyslipidemia and metoprolol for those with coronary artery disease were the commonly prescribed AHDs.


Assuntos
Diabetes Mellitus Tipo 2 , Hipertensão , Antagonistas de Receptores de Angiotensina/farmacologia , Inibidores da Enzima Conversora de Angiotensina , Anti-Hipertensivos/uso terapêutico , Pressão Sanguínea , Diabetes Mellitus Tipo 2/tratamento farmacológico , Feminino , Humanos , Hipertensão/tratamento farmacológico , Hipertensão/epidemiologia , Índia/epidemiologia , Masculino , Morbidade , Estudos Retrospectivos , Fatores de Risco
2.
Artigo em Russo | MEDLINE | ID: mdl-34486850

RESUMO

The article presents results of comparative analysis of morbidity and mortality of diseases of circulatory system in the Republic of Buryatia in 2003-2018. The population mortality depends on identification of risk factors for cardiovascular diseases, diseases of circulatory system and subsequent coverage of population with medical care, including dispensary monitoring. The analysis was based on data from State statistical reporting forms and official data of the Territorial Board of the Federal State Statistics Service in the Republic of Buryatia, including the form № 12 "The information on number of diseases registered in patients residing in area of medical organization servicing activity"; the form № 025-12/s "The Out-Patient Registration Card"; the form № 25-2/y "The Statistical Coupon for Final (updated) Diagnosis Registration". The study was carried out using statistical, analytical and comparative analysis methods. Currently, in the Republic of Buryatia, diseases of circular system occupying second place in the structure of total morbidity (15.7%) and primary disability of adult population (28.6%) are among leading cause of total population mortality (41.6%).


Assuntos
Doenças Cardiovasculares , Sistema Cardiovascular , Adulto , Doenças Cardiovasculares/epidemiologia , Humanos , Morbidade , Pacientes Ambulatoriais , Fatores de Risco
3.
Artigo em Russo | MEDLINE | ID: mdl-34486854

RESUMO

All around the world, about 570 000 of new cases of cervical cancer are diagnosed annually and more than 300 000 of women die of this pathology. In the Russian Federation, in 2018, more than 17 500 of new cases of cervical cancer were diagnosed and more than 6 000 of women died of this pathology. The purpose of the study was to analyze incidence and mortality of cervical cancer in 2007-2018. The analysis of incidence rates of cervical cancer in the Russian Federation in 2007-2018 established steady trend of increasing of incidence rate from 12.8 (2007) to 15.8 (2018). The incidence rate increased up to 26.6%. The increasing is most pronounced in the age groups of 35-39, 40-44 and 45-49 years. The analysis of dynamics of mortality rates established relative stability indices in 2007-2018 (5.11 and 5.07 in standardized rates per 100 000). The decrease of 2018 as compared to 2007 made up to 0.78%. In most age groups mortality rates are decreasing. However, significant increase of mortality rate in age group of 40-44 years was established amounted up to 25%.


Assuntos
Neoplasias do Colo do Útero , Adulto , Feminino , Humanos , Incidência , Morbidade , Mortalidade , Federação Russa/epidemiologia , Neoplasias do Colo do Útero/epidemiologia
4.
Artigo em Russo | MEDLINE | ID: mdl-34486860

RESUMO

Currently, the characteristic of dynamics of morbidity of mental disorders of population of the Russian Federation is its increasing simultaneously with changing in structure of contingents in the direction of decreasing number of patients subjected to dispensary monitoring. The study of influence of medical organizational factors on morbidity of mental disorders demonstrated the role of provision with psychiatrists in dynamics of prevalence of mental disorders. The improvement of management of patients with mental disorders should be supported by appropriate resources and adaptation of mental service to actual conditions, in particular, solving the problem of manpower deficiency of psychiatrists.


Assuntos
Transtornos Mentais , Psiquiatria , Humanos , Transtornos Mentais/epidemiologia , Transtornos Mentais/terapia , Morbidade , Prevalência , Recursos Humanos
5.
Artigo em Russo | MEDLINE | ID: mdl-34486868

RESUMO

The common coding of main diagnosis (so-called "manual coding") is accompanied by quite many errors associated with inobservance of classification algorithm and subjective causes that in statistical morbidity and mortality data corruption. The article presents the results of implementing automated system of diagnosis coding by the ICD-10 in the departments of the Medicosanitary Unit of MVD of Russia in City of Moscow. The functional and time losses and the error rate were studied under manual coding and automated coding system. In case of common coding of complete clinical diagnosis of one discharged patient per day, it takes from 5 to 15 minutes, for coding diagnoses of all discharged patients - about 1 hour. The number of errors in common coding made up to 14.1% (n=2472) and in case of automated coding it made up to 1.5% (n= 63, p>0.05). The application of automated coding system in medical organizations ensures exact correspondence of clinical and statistical diagnosis, unifies wording of clinical diagnosis, minimizes subjective deviations from algorithm of the ICD-10.


Assuntos
Classificação Internacional de Doenças , Unidades Móveis de Saúde , Algoritmos , Humanos , Morbidade , Alta do Paciente
6.
J Coll Physicians Surg Pak ; 31(9): 1085-1088, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34500526

RESUMO

OBJECTIVE: To identify the risk factors for postoperative complications of stoma closures. STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Department of General Surgery, Izmir University of Health Sciences, Tepecik Training and Research Hospital, Izmir Turkey from October 2008 to December 2018. METHODOLOGY: A total of 179 patients were divided into two groups according to presence or absence of postoperative complications. Differences between these two groups were analysed with tests of proportion; p <0.05 value was considered statistically significant. The results are reported as odds ratios (ORs) with 95% confidence interval (CI). RESULTS: The median age of the patients with postoperative complications was 57.00 (40.00-67.00) and 30/55 (54.5%) of them were males. American Society of Anesthesiology (ASA) score and coronary artery disease had significant association with postoperative complications of stoma closure (p=0.033, p=0.024). Although colostomy was not associated with presence of postoperative complications, but when the authors analysed correlations of colostomy with postoperative complications separately, it was found that colostomy was a risk factor for postoperative ileus (OR 0.257, 95% CI 0.081-0.821; p= 0.026). CONCLUSION: ASA score and coronary artery disease should be considered as risk factors for complications of stoma closure. Colostomy should be considered as a risk factor for postoperative ileus. Key Words: Colostomy, Ileostomy, Stoma closure, Risk factors.


Assuntos
Colostomia , Ileostomia , Humanos , Ileostomia/efeitos adversos , Masculino , Morbidade , Complicações Pós-Operatórias/epidemiologia , Estudos Retrospectivos , Fatores de Risco
7.
Niger J Clin Pract ; 24(8): 1117-1125, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34397018

RESUMO

Background: : Visual morbidities increase the burden of care and negatively impact the quality of life of older people. Few empirical reports exist on the visual status of older Nigerians. Aim: This study describes the visual morbidities and determinants of visual impairment among persons aged 60 years and above who presented at a geriatric center in southwestern Nigeria and discusses the merits of focused geriatric care at a single location. Materials and Methods: Data were obtained from electronic health records and case files of 628 older patients (≥60 years) who attended the facility between January 1, 2014 and December 31, 2018. Data extracted included, age, sex, married status, occupational status, visual acuity, eye diagnoses, eye medications, previous surgeries, and anthropometric measurements. Results: Mean age of patients was 70.1 ± 7.4 years and 378 (60.2%) were females. Two out of every three patients had more than one visual diagnosis. Significantly, glaucoma (P < 0.001) and cataract (P = 0.01) were common among men, whereas dry eye syndrome (P < 0.001) and allergic conjunctivitis (P = 0.01) were common in women. Antiglaucoma medications (55.8%) were the commonest medications used and 21.0% had previous eye surgery. Assessment of presenting visual acuity demonstrated that 28.7% of patients had moderate-severe visual impairment (MSVI) in both eyes at presentation while 10.3% were bilaterally blind. Increasing age (P < 0.001) and male sex (P = 0.01) were the factors significantly associated with blindness. Conclusion: MSVI and blindness were common in our setting with glaucoma and cataract being the most prevalent associated diagnosis. Information obtained should stimulate advocacy for the prompt management of preventable causes of poor vision in older Nigerians.


Assuntos
Catarata , Baixa Visão , Idoso , Cegueira , Atenção à Saúde , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Morbidade , Nigéria/epidemiologia , Prevalência , Qualidade de Vida
8.
J Pak Med Assoc ; 71(8): 2005-2008, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34418020

RESUMO

OBJECTIVE: To assess the presence of psychiatric morbidity and associated socio-demographic factors among informal caregivers of children suffering from intellectual developmental disorders. METHODS: The analytical cross-sectional study was conducted at the Neurology Department of a tertiary care hospital in Rawalpindi, Pakistan, from January 1, 2018, to December 31, 2019, and comprised informal caregiver of children diagnosed with intellectual developmental disorders presenting at the paediatric or neurology outpatient clinics of the hospital. Intellectual developmental disorder was diagnosed by consultant neurologists or psychiatrists or paediatricians on the basis of International Classification of Diseases-11 criteria. Psychiatric morbidity in the informal caregiver was assessed using the 12-item general health questionnaire. Data was analysed using SPSS 23, and binary logistic regression was applied to assess association. RESULTS: Of the 500 informal caregivers, 323(64.6%) showed psychiatric morbidity. Increasing age and comorbid epilepsy among the patients were significantly related to the presence of psychiatric morbidity among the informal caregivers (p<0.05). CONCLUSIONS: Majority of informal caregivers of children with learning difficulties were found to have psychiatric morbidity.


Assuntos
Cuidadores , Deficiência Intelectual , Criança , Estudos Transversais , Deficiências do Desenvolvimento/epidemiologia , Humanos , Deficiência Intelectual/epidemiologia , Morbidade
9.
Ned Tijdschr Geneeskd ; 1652021 06 17.
Artigo em Holandês | MEDLINE | ID: mdl-34346644

RESUMO

Tobacco use disorder is a major contributor to morbidity and mortality worldwide. Yet, in contrast to other substance use disorders, tobacco use disorder is often considered as an unhealthy lifestyle. In this article we argue that tobacco use disorder should be considered similar to other addictive disorders, and summarize supporting arguments from genetics, neuroscience, as well as treatment perspective. Considering Tobacco Use Disorder as an addictive disorder will facilitate awareness among health professionals that patients with this condition should receive proper treatment that should be reimbursed by health insurance. This will reduce the health burden of tobacco use disorder, improve quality of life of individual patients and reduce societal health care costs.


Assuntos
Comportamento Aditivo , Transtornos Relacionados ao Uso de Substâncias , Tabagismo , Comportamento Aditivo/epidemiologia , Humanos , Estilo de Vida , Morbidade , Qualidade de Vida , Tabagismo/complicações , Tabagismo/epidemiologia
10.
Medicina (Kaunas) ; 57(8)2021 Jul 27.
Artigo em Inglês | MEDLINE | ID: mdl-34440965

RESUMO

Background and objectives: In oral and maxillofacial operations, the iliac crest is a commonly used donor site from which to harvest bone for augmentation prior to dental implantation or for reconstruction of jaw defects caused by trauma or pathological lesions. In an aging society, the proportion of elderly patients undergoing iliac crest bone grafting for oral augmentation is growing. Although postoperative morbidity is usually moderate to low, the age and health of the patient should be considered as risk factors for complications and delayed mobilization after the operation. The aim of this retrospective study was to evaluate the postoperative morbidity and complications in elderly patients after the harvesting of iliac crest bone grafts for oral surgery. Material and Methods: Data were collected from a total of 486 patients (aged 7-85) who had a surgical procedure that included the harvesting of iliac crest bone grafts for intraoral transplantation. All patients were operated on between 2005 and 2021 in the Department for Oral and Maxillofacial Surgery of the University Hospital in Aachen, Germany. As parameters for postoperative morbidity and complications, gait disturbances, hypesthesia of cutaneous nerves, incision hernias, iliac crest fractures, delayed wound healing, and unfavorable scar formation at the donor site were all evaluated. Results: The study was performed with 485 patients due to the exclusion of one patient as the only one from whom grafts were taken from both sides. When younger and older patients were compared, neither gait disturbances (p = 0.420), nor hernias (p = 0.239), nor fractures (p = 0.239), nor hypesthesia (p = 0.297), nor wound healing delay (p = 0.294), nor scar problems (p = 0.586) were significantly different. However, the volume of the graft was significantly correlated with the duration of the hospital stay (ρ = 0.30; p < 0.01) but not with gait disturbances (ρ = 0.60; p = 0.597). Additionally, when controlling for age (p = 0.841), sex (p = 0.031), ASA class (p = 0.699), preexisting orthopedic handicaps (p = 0.9828), and the volume of the bone graft (p = 0.770), only male sex was associated with the likelihood of suffering gait disturbances (p = 0.031). Conclusions: In conclusion, harvesting bone grafts from the anterior iliac crest for intraoral augmentation is a safe procedure for both young and elderly patients. Although there is some postoperative morbidity, such as gait disturbances, hypesthesia, scar formation, or delayed wound healing at the donor site, rates for these minor complications are low and mostly of short duration. Major complications, such as fractures or incision hernias, are very rare. However, in our study, the volume of the bone graft was associated with a longer stay in hospital, and this should be considered in the planning of iliac crest bone graft procedures.


Assuntos
Ílio , Coleta de Tecidos e Órgãos , Idoso , Transplante Ósseo , Humanos , Masculino , Morbidade , Dor Pós-Operatória , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Estudos Retrospectivos
11.
Medicine (Baltimore) ; 100(32): e26912, 2021 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-34397928

RESUMO

ABSTRACT: It is essential to monitor pharmacological treatment for schizophrenic outpatients regularly in clinical practice. Especially in China, the situation of common prescribing patterns remains unclear. The objective of this study is to reveal real-world treatment prescription patterns of antipsychotics for schizophrenia patients in a representative large tertiary hospital in China.This study is a cross-sectional observational analysis of outpatients with schizophrenia in a large tertiary psychiatric hospital in Beijing, China, from May 11th to 24th, 2019. Data on subjects' socio-demographic and clinical characteristics, prescriptions of psychotropic drugs were collected from the electronic medical record (EMR) system with a standardized protocol. A multivariate analysis was performed to explore the potential association between antipsychotics treatments and subjects' characteristics.Of the 1940 patients included in this study, only 1470 (75.77%) patients were prescribed antipsychotic medications. 1228 (83.53%) patients were prescribed second-generation antipsychotics (SGAs), 202 (13.74%) patients were treated only with first-generation antipsychotics (FGAs), 40 (2.72%) were prescribed both SGAs and FGAs. The proportion of single SGAs prescriptions was significantly higher than that of single FGAs antipsychotics in each course of monotherapy group, especially among patients with the course less than 2 years (96.08%). Risperidone was most frequently prescribed antipsychotic medication during the study (29.86%, 439 out of 1470). Intermediate-acting sedative benzodiazepines were the most commonly co-prescribed psychotropic class at 23.66%. Long-acting injectable antipsychotics (LAIs) could be the prescribing trend in clinics. Disease course, self-paying cost and LAI antipsychotic use were independently associated with antipsychotics treatments.Second-generation antipsychotics showed domination in prescriptions. More concerns should be paid with concomitant psychiatric medications in clinics.


Assuntos
Antipsicóticos/uso terapêutico , Pacientes Ambulatoriais , Esquizofrenia/tratamento farmacológico , Adolescente , Adulto , Idoso , China/epidemiologia , Estudos Transversais , Feminino , Seguimentos , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Morbidade/tendências , Estudos Retrospectivos , Esquizofrenia/epidemiologia , Adulto Jovem
12.
Acta Chir Plast ; 63(2): 46-51, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34404216

RESUMO

BACKGROUND: Traumatic thumb loss is a serious injury affecting patient´s ability to work and participate in activities of daily life. The main goal for a plastic surgeon is to restore hand grip, often by microsurgical methods. However, patients should be informed of all effects associated with tissue harvesting. The aim of the study was to assess the impact on donor foot and gait cycle in patients who have undergone thumb reconstruction using twisted-toe technique modified by Kempný. MATERIAL AND METHODS: Twelve patients participated in the study: all suffered a thumb loss between the years 2003 and 2011 and the twisted-toe technique for thumb reconstruction was utilized. The changes in foot pressure distribution and lower extremity joint loading were evaluated. RESULTS: The differences in total maximal plantar pressure, pressure time integral, contact area, and maximum force between the affected and non-affected foot were statistically significant (P 0.1). No significant differences of temporal gait parameters between the affected and non-affected extremity were observed; however, statistically significant differences in kinetics parameters, frontal ankle and knee moments were detected. CONCLUSION: Donor limb functionality and anatomical disability were assessed using pedobarography systems and 3D-gait analysis. The recorded differences in plantar pressure distribution (increased pressure in I., IV. and V. metatarsal areas) and overload of the medial compartment of the knee joint were the most significant findings. Therefore, wearing individually adapted shoe insoles as prevention of osteoarthrosis might be beneficial for patients after thumb reconstruction by a twisted-toe technique.


Assuntos
Amputação Traumática , Polegar , Mãos , Força da Mão , Humanos , Morbidade , Polegar/cirurgia , Dedos do Pé
13.
Artigo em Inglês | MEDLINE | ID: mdl-34444053

RESUMO

Although mental health problems among Hong Kong university students are serious, there is a lack of studies examining the psychometric properties of related assessment scales and correlates. This study attempted to validate the Depression Anxiety Stress Scales (DASS) in Hong Kong university students and examine the demographic (gender), time (cohort), and well-being correlates (positive youth development attributes and life satisfaction) of psychological morbidity. Confirmatory factor analysis (CFA) was used to examine the factor structure of the DASS (n = 6704). Gender and cohort invariance were further established using a multigroup CFA. The three-factor model of the DASS showed a superior fit and factorial invariance across gender and five different cohorts. Regarding gender and cohort correlates of psychological morbidity, males exhibited more depression, anxiety, and stress symptoms than their female counterparts. The intensity of psychological distress also escalated after the Umbrella Movement in 2014. Furthermore, well-being measures (positive youth development and life satisfaction) were negatively associated with depression, anxiety, and stress. In short, the Chinese DASS demonstrated good psychometric properties. This study also showed that gender, cohort (occurrence of political events), and well-being were associated with psychological morbidity indexed by the DASS measures.


Assuntos
Depressão , Universidades , Adolescente , Ansiedade/epidemiologia , Depressão/diagnóstico , Depressão/epidemiologia , Feminino , Hong Kong/epidemiologia , Humanos , Masculino , Morbidade , Escalas de Graduação Psiquiátrica , Psicometria , Reprodutibilidade dos Testes , Estresse Psicológico/epidemiologia , Estudantes
14.
J Card Surg ; 36(10): 3599-3606, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34363420

RESUMO

BACKGROUND: Time of day for surgical procedures has been a topic of considerable controversy, with some suggesting that later operating times are associated with worse outcomes. METHODS: All patients who underwent open cardiac surgery from 2011 to 2018 were included. Patients that had ventricular assist devices, heart transplant, transcatheter aortic valves, aortic dissections, and emergent operations were excluded. Primary outcomes included postoperative mortality and survival; secondary outcomes included postoperative complications and readmission. RESULTS: The initial patient population consisted of 7883 patients who underwent index cardiac surgery. Following propensity matching (3:1), there were 2569 patients in the a.m. cohort (7-11 a.m.) and 860 patients in the p.m. cohort (3-11 p.m.). All baseline characteristics were matched to equivalent proportions. Total intensive care unit time following surgery was longer for the a.m. cohort (46.5 vs. 40.0 h; p<.001). Otherwise, there was no significant difference between cohorts including operative mortality (1.83% vs 2.21%; p= .48). On multivariable analysis, p.m. surgery was not significantly associated with 30 days mortality (hazard ratio [HR]: 0.96 [0.60, 1.53]; p= .86] or mortality over the study follow-up (HR: 0.87 [0.73, 1.03]; p= .10]. For propensity-matched cohorts, Kaplan-Meier survival at 30 days (97.9% vs. 97.4%; p= .44), 1 (93.4% vs 93.9%; p= .51), and 5 years (80.9% vs. 80.2%; p= .84) was not significantly different between cohorts. CONCLUSION: Short- and long-term mortality, hospital readmission, and postoperative complications were not significantly different between patients that underwent cardiac surgery starting in the a.m. versus patients who had cases that started in the afternoon.


Assuntos
Procedimentos Cirúrgicos Cardíacos , Mortalidade Hospitalar , Humanos , Morbidade , Complicações Pós-Operatórias/epidemiologia , Pontuação de Propensão , Estudos Retrospectivos , Fatores de Risco , Fatores de Tempo , Resultado do Tratamento
15.
Wiad Lek ; 74(7): 1628-1633, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34459763

RESUMO

OBJECTIVE: The aim: To improve epidemiological monitoring of pertussis by analyzing the disease morbidity during 1995-2017 in Ukraine, to make a prognosis. PATIENTS AND METHODS: Materials and methods: Analysis of the pertussis morbidity during 1995-2017 using the data of the Ministry of Health of Ukraine. The cyclicity was determined by Fourier spectral analysis. The models of prognosis were constructed using polyharmonic regression and an exponential smoothing algorithm. Cartographic analysis and integrated indicators (multiyear index of the prevalence rate, mean square deviation, mean the multiyear pace of the gain in the prevalence rate) were used to determine the areas of risk. Summarized data were used to calculate the generalized coefficient. RESULTS: Results: The pertussis morbidity cycle has 5 years intervals in Ukraine. The prognosis is for increasing the pertussis morbidity from 4.91-5.54 to 5.48-7.06 per 100.000 people. The generalized coefficient was significantly higher in western part (83.3%) than in central (50.0%) and eastern (16.6%) parts. The study showed that population reproduction rates, natural population increase, and the proportion of people against vaccination were higher in the western part than in other parts of the country. CONCLUSION: Conclusions: The pertussis cyclicity depends on the internal mechanisms of interaction in the ecological system. There is a prognosis of worsening the epidemic situation of pertussis spreading. The risk area is the western part of Ukraine, which is characterized by active demographic processes and a greater number of people who are negative about vaccination.


Assuntos
Coqueluche , Humanos , Morbidade , Prevalência , Ucrânia/epidemiologia , Vacinação , Coqueluche/epidemiologia
16.
Eur J Endocrinol ; 185(4): 577-586, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34374651

RESUMO

Objective: Insulinomas are rare functional pancreatic neuroendocrine tumours. As previous data on the long-term prognosis of insulinoma patients are scarce, we studied the morbidity and mortality in the Finnish insulinoma cohort. Design: Retrospective cohort study. Methods: Incidence of endocrine, cardiovascular, gastrointestinal and psychiatric disorders, and cancers was compared in all the patients diagnosed with an insulinoma in Finland during 1980-2010 (n = 79, including two patients with multiple endocrine neoplasia type 1 syndrome), vs 316 matched controls, using the Mantel-Haenszel method. Overall survival was analysed with Kaplan-Meier and Cox regression analyses. Results: The median length of follow-up was 10.7 years for the patients and 12.2 years for the controls. The long-term incidence of atrial fibrillation (rate ratio (RR): 2.07 (95% CI: 1.02-4.22)), intestinal obstruction (18.65 (2.09-166.86)), and possibly breast (4.46 (1.29-15.39) and kidney cancers (RR not applicable) was increased among insulinoma patients vs controls, P < 0.05 for all comparisons. Endocrine disorders and pancreatic diseases were more frequent in the patients during the first year after insulinoma diagnosis, but not later on. The survival of patients with a non-metastatic insulinoma (n = 70) was similar to that of controls, but for patients with distant metastases (n = 9), the survival was significantly impaired (median 3.4 years). Conclusions: The long-term prognosis of patients with a non-metastatic insulinoma is similar to the general population, except for an increased incidence of atrial fibrillation, intestinal obstruction, and possibly breast and kidney cancers. These results need to be confirmed in future studies. Metastatic insulinomas entail a markedly decreased survival.


Assuntos
Insulinoma/epidemiologia , Neoplasias Pancreáticas/epidemiologia , Adulto , Idoso , Estudos de Casos e Controles , Estudos de Coortes , Comorbidade , Finlândia/epidemiologia , Seguimentos , História do Século XX , História do Século XXI , Humanos , Incidência , Insulinoma/complicações , Insulinoma/diagnóstico , Insulinoma/mortalidade , Pessoa de Meia-Idade , Morbidade , Neoplasias Pancreáticas/complicações , Neoplasias Pancreáticas/diagnóstico , Neoplasias Pancreáticas/mortalidade , Prognóstico , Estudos Retrospectivos , Análise de Sobrevida , Fatores de Tempo
18.
Medicina (Kaunas) ; 57(7)2021 Jul 06.
Artigo em Inglês | MEDLINE | ID: mdl-34356969

RESUMO

Background and Objectives: This study aimed to investigate whether initial symptoms of COVID-19 are associated with mortality and morbidity. Materials and Methods: The data of 5628 laboratory-confirmed COVID-19 patients were collected by the Korea Centers for Disease Control and Prevention. The maximum level of morbidity during hospital admission was classified as mild or severe, and patient mortality was recorded. Clinical symptoms were categorized as respiratory, gastrointestinal, general, and neurologic symptoms. The hazard ratios (HRs) for clinical symptoms associated with mortality were analyzed using the Cox proportional hazards model. The odds ratios (ORs) for clinical symptoms associated with morbidity were analyzed using the logistic regression model. Results: Of the included COVID-19 patients, 15.4% (808/5253) were classified as having severe morbidity. Morbidity was related to the clinical symptoms of cough, sputum, shortness of breath, vomiting/nausea, diarrhea, fever, and altered mental status or confusion. According to the symptom categories, respiratory and general symptoms were related to high morbidity (OR = 1.41, 95% CI = 1.30-1.53, p < 0.001 for respiratory symptom and OR = 1.37, 95% CI = 1.18-1.59, p < 0.001 for general symptom). Mortality was associated with the clinical symptoms of shortness of breath, fever, and altered mental status or confusion. Among the symptom categories, respiratory symptoms were associated with a 1.17-fold increased HR for mortality (95% CI = 1.04-1.32, p = 0.008). Conclusions: Initial respiratory symptoms were related to high morbidity and mortality in COVID-19 patients.


Assuntos
COVID-19 , Centers for Disease Control and Prevention, U.S. , Humanos , Morbidade , República da Coreia/epidemiologia , SARS-CoV-2 , Estados Unidos
19.
Adv Gerontol ; 34(3): 396-403, 2021.
Artigo em Russo | MEDLINE | ID: mdl-34409818

RESUMO

The problem of thyroid cancer in Russia became especially relevant after the accident at the Chernobyl nuclear power plant in 1986. We can trace the dynamics of morbidity in the population of Leningrad-Saint Petersburg from 1980 to 2018. for the periods before and after the accident, even before the inclusion of this localization of malignant neoplasms in the state reports. Thyroid cancer can be attributed to rare malignancies. In addition to morbidity and mortality, it is planned to consider such analytical indicators that are practically not used in Russia as the reliability of accounting, partial mortality and five-year survival of patients with thyroid cancer calculated according to the international standard. In many territories of Russia and abroad, an increase in the incidence of thyroid cancer has been detected, which to some extent may be associated with its overdiagnosis, against the background of a decrease in the population's mortality from this cause. Favorable patterns were found in relation to the reliability of accounting in Russia and especially in Saint Petersburg. Some structural changes were detected in the histological structure of thyroid cancer.


Assuntos
Neoplasias , Glândula Tireoide , Humanos , Morbidade , Reprodutibilidade dos Testes , Federação Russa/epidemiologia
20.
Curr Cardiol Rep ; 23(10): 143, 2021 08 19.
Artigo em Inglês | MEDLINE | ID: mdl-34410533

RESUMO

PURPOSE OF REVIEW: The prevalence of cardiovascular disease despite good medical therapy is on the rise, driven by risk factors such as hypertension, diabetes, hypercholesterolemia, and obesity. As healthcare providers, we must seek to better advise patients on preventative strategies through lifestyle changes. RECENT FINDINGS: Guideline recommendations have been published by professional societies on the prevention of heart disease through lifestyle changes; however, limited education and experience with these lifestyle-modifying methods hinders appropriate counseling and treatment of patients. Robust data support the use of lifestyle medicine to reduce cardiovascular morbidity and risk. These include, a more plant-based whole food diet, regular exercise, stress relief, connectedness, and other lifestyle approaches. This review will help further the understanding of the front-line clinician in cardiovascular prevention.


Assuntos
Doenças Cardiovasculares , Hipertensão , Doenças Cardiovasculares/prevenção & controle , Exercício Físico , Humanos , Estilo de Vida , Morbidade
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