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1.
Braz. j. oral sci ; 20: e211236, jan.-dez. 2021. ilus
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1253730

RESUMO

Aim: Dental imaging has been widely used for diagnosis in dentistry. However, dental X-ray may induce cytotoxicity leading to apoptosis in oral mucosa cells. The present study aimed to observe the maturation pattern of buccal and gingival cells after exposure to X-ray radiation from analog/digital panoramic scanning and cone beam computed tomography (CBCT). Methods: The research samples were 40 subjects who fulfilled the inclusion and exclusion criteria. The subjects were divided into the exposed (patients who received analog/digital panoramic radiography or CBCT) and controlled (patients who had no radiography examinations) groups, with 10 subjects in each group. Exfoliative cytology smears were obtained from buccal mucosa and gingiva before exposure (or on day 0 for the control group) and 10 days later. The cells were stained with the Papanicolaou method. Then, the superficial, intermediate, and parabasal cells were counted in each glass slide. Results: No significant differences (p > 0.05) were observed among all cell types between day 0 and 10 in the control group. Meanwhile, after exposure to three kinds of radiography examinations, the frequency of intermediate cells in buccal mucosa and gingiva increased (p < 0.05), but that of superficial cells decreased (p < 0.05) significantly. No significant difference was found in the parabasal cells (p > 0.05). The frequency differences between intermediate and superficial cells showed no significant difference between the buccal mucosa and gingiva. Conclusion: Analog/digital panoramic radiography and CBCT exposure can induce cytotoxicity by altering the maturation pattern of buccal mucosa cells and gingiva, so it is strongly recommended to only perform these procedures if necessary and avoid repeated exposure to the same patient


Assuntos
Humanos , Radiografia Panorâmica , Tomografia Computadorizada de Feixe Cônico , Teste de Papanicolaou , Gengiva , Mucosa Bucal
2.
Clin Oral Implants Res ; 32 Suppl 21: 138-156, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34642988

RESUMO

OBJECTIVES: To assess the outcomes of soft tissue augmentation, in terms of change in level and thickness of mid-buccal mucosa, at implants sites in the zone of the aesthetic priority. MATERIAL AND METHODS: MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials databases were searched (last search on 1 June 2020). Inclusion criteria were studies reporting outcomes of different materials and timing of grafting in patients undergoing soft tissue augmentation at implant sites in the aesthetic zone with a follow-up of ≥1 year after implant placement. Outcome measures assessed included changes in level and thickness of mid-buccal mucosa, implant survival, peri-implant health and patients' satisfaction. RESULTS: Eighteen out of 2,185 articles fulfilled the inclusion criteria. Meta-analysis revealed a significant difference in vertical mid-buccal soft tissue change (0.34 mm, 95% CI: 0.13-0.56, p = .002) and mid-buccal mucosa thickness (0.66 mm, 95% CI: 0.35-0.97, p < .001) following immediate implant placement in favour of the use of a graft versus no graft. Mean difference in mid-buccal mucosa level following delayed implant placement (0.17 mm, 95% CI: 0.01-0.34, p = .042) was also in favour of the use of a graft versus no graft. With regard to mucosa thickness, the use of a graft was not in favour compared with no graft following delayed implant placement (0.22 mm, 95% CI: -0.04-0.47, p = .095). Observed changes remained stable in the medium term. CONCLUSION: Soft tissue augmentation in the zone of the aesthetic priority results in less recession and a thicker mid-buccal mucosa following immediate implant placement and less recession in mid-buccal mucosa following delayed implant placement compared with no graft.


Assuntos
Implantação Dentária Endo-Óssea , Estética Dentária , Humanos , Mucosa Bucal
3.
Georgian Med News ; (318): 43-49, 2021 Sep.
Artigo em Russo | MEDLINE | ID: mdl-34628377

RESUMO

The quality of the formation of the relief of the soft tissues of the prosthetic bed after surgical tooth extraction is a significant criterion for the success of further permanent removable prosthetics. However, after a surgical operation, an inflammatory response in the soft tissues of the oral cavity inevitably occurs, and their deformation also occurs. These processes can be aggravated due to insufficient control over inflammatory phenomena with possible functional overload of the prosthetic bed at the stage of primary orthopedic rehabilitation with the help of immediate prosthetics. Objectivity of monitoring the course of inflammation can be ensured using the methods of vital staining of the oral mucosa and analysis of the dynamics of vascular changes in the area of ​​surgical intervention. The use of iodine-containing diagnostic solutions, revealing an increased content of glycogen and inflammatory enzymes in the mucous membrane of this area, contributes to the early detection of the latent inflammatory process. Glycogen is the main energy source for cellular and glycolytic biochemical inflammatory reactions, and is also present in the adventitia of newly formed vessels in the focus of damage, and acts as a marker of changes in the density of the vascular network. Thus, the aim of the study is to optimize the control over the course of latent inflammation in the area of ​​the prosthetic bed at the stage of using removable lamellar immediate prostheses in patients with partial absence of teeth due to surgical extraction. The study included 2 groups of patients with the absence of 4 to 10 teeth due to surgical extraction. The study group of patients underwent the manufacture of lamellar immediate-prostheses under the control of diagnostic staining of the mucous membrane. For patients of the second group, prostheses were made using the traditional method. According to the results of the study, in the study group, the time for complete resolution of inflammatory phenomena and the formation of the optimal state of the prosthetic bed was reduced by 33% compared to the control group. It was found that early detection of foci of chronic inflammation in the area of ​​the prosthetic bed makes it possible to promptly correct the tactics of orthopedic treatment by transforming the bases of immediate prostheses, which generally increased the quality of early prosthetics in this study.


Assuntos
Prótese Parcial Removível , Mucosa Bucal , Humanos , Boca , Mucosa Bucal/cirurgia , Próteses e Implantes , Coloração e Rotulagem
4.
J Contemp Dent Pract ; 22(7): 745-750, 2021 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-34615778

RESUMO

AIM AND OBJECTIVE: To define the genotoxic potential of tobacco and alcohol in the oral mucosa through a micronuclei (MN) test. MATERIALS AND METHODS: Samples of exfoliative cells from oral mucosa were collected using superficial scraping of the right- and left-cheek mucosa of 83 patients divided into four groups, namely: (G1) 24 individuals abstaining from tobacco and alcoholic beverages; (G2) 23 individuals who smoke and abstain from alcoholic beverages; (G3) 24 smokers and alcoholics; and (G4) 12 individuals who consume alcohol and abstain from tobacco. The samples were stained with Giemsa-Wright, and the frequencies of MN, binucleated cells, and metanuclear changes were recorded in the samples of each group (1,000 cells per patient). RESULTS: Analysis of variance (ANOVA) showed a difference between groups for changes concerning karyorrhexis (p = 0), pycnosis (p = 0.002), karyolysis (p = 0.003), and binucleated cells (p = 0.046). As for the total number of changes, G3, G2, and G4, respectively, were significantly higher than G1. CONCLUSION: It is suggested that the influence of smoking and drinking on exfoliating cells of oral mucosa may cause metanuclear changes due to genetic changes that these products cause, and the MN test is effective in detecting and monitoring such changes. CLINICAL SIGNIFICANCE: MN test may work for constantly monitoring the oral mucosa of smokers and/or alcoholic patients, so that early cell changes may be diagnosed, preventing the genesis of oral cancer.


Assuntos
Alcoolismo , Tabaco , Dano ao DNA , Humanos , Mucosa Bucal , Projetos Piloto
5.
Mater Sci Eng C Mater Biol Appl ; 128: 112255, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34474817

RESUMO

OBJECTIVES: The aim of this work was to combine engineered hard and soft tissue, adopting a new method for interfacial adhesion of osteo-mucosal construct. We hypothesized that the chemical procedure involved in this method not only adheres the components, but also improves the cell growth inside them. METHODS: 3D-printed functionally-graded porous hard-tissue scaffolds were characterized, functionalized by aminolysis and tyrosinase, and accommodated by human osteoblast cells. Introducing amino groups through aminolysis and inducing dopaquinones by tyrosinase can take part in the Michael additions to cause the adhesion. Subsequently, fully-differentiated engineered oral mucosa was formed directly on the surface of hard tissue. Constructs were assessed in term of morphology, structure, chemical composition, histology, and cytocompatibility. Interfacial adhesion was compared to a control group prepared by using a biological glue for the attachment of the soft and hard tissues. RESULTS: The data confirmed higher proliferation of osteoblast cells via aminolysis and improved osteoblast cells distribution and differentiation by incorporation of tyrosinase in collagen. There was evidence of multilayered, stratified epithelium on the osteo-mucosal model with viable fibroblasts and osteoblasts within the lamina propria and bone tissue layers. Our method of adhesion resulted in cohesive debonding within the engineered soft tissue; while in the control group, adhesive debonding and complete separation of the oral mucosa from the hard tissue was observed. Although the shear strength of the osteo-mucosal model (157.6 kDa ± 25.1) was slightly higher than that of the control group (149.4 kDa ± 23.1), there was no statistically significant difference between them (p > 0.05). However, the advantage of our in situ adhesion approach is the absence of a barrier like glue which can disrupt direct cellular communications between tissues. SIGNIFICANCE: This study provides a novel method of directly combining tissue-engineered human bone with oral mucosa, which has the potential to improve cell-ingrowth and tissue integration. This engineered tissue construct, after further optimization, can be used clinically as a graft material in various oral surgeries and can also be employed as an in vitro model to investigate many aspects of oral diseases and examine dental materials and oral health care products as a replacement of in vivo models.


Assuntos
Engenharia Tecidual , Tecidos Suporte , Humanos , Mucosa Bucal , Osteoblastos , Porosidade
6.
Urologiia ; (4): 5-10, 2021 Sep.
Artigo em Russo | MEDLINE | ID: mdl-34486268

RESUMO

INTRODUCTION: The recurrent course of the disease stricture is a complex problem for both the patient and the operating surgeon and requires an integrated approach to treatment only in expert centers. PURPOSE OF THE STUDY: To assess the effectiveness of methods of surgical treatment of recurrent urethral strictures. MATERIALS AND METHODS: At the University Clinic of Urology, Russian National Research Medical University named after N.I. Pirogov, an analysis of the results of surgical treatment of patients with recurrent urethral stricture from 2012 to 2020 was carried out. This work included patients who underwent surgical treatment for recurrent urethral stricture. A total of 120 men were involved in the work. The median length of the stricture was (min-max) - 2 (0.5-16 cm). In 95 (79.1%) patients, stricture of the bulbous urethra, in 15 (12.5%) - in the penile urethra, in 2 (1.7%) patients had panurethral stricture, in 6 (5.0%) - membranous urethra and in 2 (1.7%) - meatus. All patients were divided into two groups: with recurrent urethral stricture after primary DVIU (group I, n=77) and recurrent urethral stricture after primary urethroplasty (group II, n=43). Depending on the method of surgical treatment of recurrent urethral stricture, patients in group I were divided into 4 subgroups. Repeated DVIU + 3 months Autocatheterization - 16 (20.8%) patients; End-to-end urethroplasty - 37 (48.1%) patients; one-stage urethroplasty with a buccal graft or skin graft - 22 (28.6%) patients; multistage urethroplasty or perineostomy - 2 (2.5%) patients. Group II was also divided into 4 subgroups. DVIU - 17 (39.5%) patients; end-to-end urethroplasty - 6 (13.9%) patients; one-stage urethroplasty with a buccal graft or skin graft - 9 (20.9%) patients; multistage urethroplasty - 11 (16.7%) patients. Median Qmax - 4.68 ml/sec. Preoperative cystostomy was observed in 31 (25.8%) patients. RESULTS: The median follow-up was 24 months (range 12 to 76 months). Depending on the method of surgical treatment of recurrent urethral stricture, the effectiveness of DVIU according to strict indications was 75.7%. End-to-end urethroplasty showed an efficiency of -88,4%. One-stage augmentation urethroplasty had an efficiency of -77,4%, and multi-stage urethroplasty showed an efficiency of 84.6%. The IPSS value for the observation period 2 years was 2.6+/-0.9 points. The average value of Qmax at the time of observation was 19.4+/-7.1 ml/sec. The effectiveness of the treatment was 82%. During the follow-up period, a relapse was noted in 22 (18%) patients. The overall effectiveness of the treatment of recurrent urethral stricture, taking into account the treatment of recurrent cases of disease recurrence, was 97.5%. CONCLUSIONS: Urethroplasty is the treatment of choice for recurrent urethral strictures, which has been shown to be more effective than DVIU. However, the results of urethroplasty for recurrent strictures are worse than for primary strictures.


Assuntos
Estreitamento Uretral , Humanos , Masculino , Mucosa Bucal , Estudos Retrospectivos , Resultado do Tratamento , Uretra/cirurgia , Estreitamento Uretral/cirurgia , Procedimentos Cirúrgicos Urológicos Masculinos
7.
Anticancer Res ; 41(9): 4203-4210, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34475039

RESUMO

AIM: The aim of this review was to evaluate the scientific literature regarding the cytogenetic damage in oral exfoliated cells of adult patients submitted to panoramic X-ray. MATERIALS AND METHODS: An extensive search of the literature was conducted on PubMed, Scopus and Web of Science databases for all studies published until April 2021 using combinations of the following keywords: "panoramic X-ray," "DNA damage," "genetic damage", "genotoxicity", "mutagenicity", cytotoxicity", "buccal cells", "oral mucosa", "tongue", "gingiva", "micronucleus assay", according to the PRISMA guidelines. All clinical studies in English language were included in the study. A total of 10 studies were identified. RESULTS: As expected, the results regarding the cytogenetic damage induced by panoramic X-ray are conflicting. Some authors have demonstrated that panoramic X-ray induces mutagenesis in oral cells, whereas others did not. After reviewing the 10 studies, two were classified as strong, four were considered moderate, and four were considered weak, according to the quality assessment components of the Effective Public Health Practice Project (EPHPP). Meta-analysis data revealed a negative response related to mutagenicity in oral cells by panoramic X-ray. CONCLUSION: Taken together, this review failed to demonstrate the association between micronucleus frequency and panoramic X-ray.


Assuntos
Análise Citogenética/métodos , Mucosa Bucal/química , Radiografia Panorâmica/efeitos adversos , Dano ao DNA , Humanos , Testes para Micronúcleos , Mucosa Bucal/efeitos dos fármacos , Mutação
8.
Georgian Med News ; (316-317): 154-158, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34511463

RESUMO

Malignant tumors are one of the leading courses of mortality in the world, and it is believed that 19% of malignant tumors are associated with environmental risk factors. The aim of the study was to establish the spectrum of distributions of an informative biomarker of the unfavorable (genotoxic) effect of the external environment on the body by determining the level of micronuclei (LMN) in buccal epithelium cells in populations of villages of the Sachkhera region (Georgia). In the inhabitants of the Sachkhere district (both sexes, 50-65 years old) living in the villages of Sareki, Sairkhe, and Chorvila, LMN was determined in the cells of the buccal epithelium. The statistical significance of the difference in LML between the village population was assessed using the analysis of variance (ANOVA). Dixon's Q test was used to identify abnormal micronuclei. The χ2 criterion was used to assess the normality of LMN distributions among residents of the villages. The distribution of the population by LMN indicators in each individual village was described as the distribution of a two-component mixture. The statistical significance of the difference between the Gaussian means of the mixture components was assessed using the Z-test. To analyze the data and visualize the results, the SPSS and Open BUGS software packages were used. Differences in the LMN of the buccal epithelium in the studied populations were revealed, which may be due to the influence of external environmental factors: in Sareki, the effect of a certain (unidentified) clearly expressed genotoxic factor (both in terms of intensity and scale of exposure) was revealed, which is accompanied by a sharp increase in LMN, while in Chorvila and Sairkhe the presence of an inducing factor is not recorded and LMN remained practically within the norms. The identification of the causal relationship between the nature of the distributions of the used biomarkers and the specificity of the incidence of the population in the villages, as well as the possible contribution of unfavorable environmental factors, is the subject of further research.


Assuntos
Dano ao DNA , Mucosa Bucal , Idoso , Teorema de Bayes , Biomarcadores , Feminino , República da Geórgia , Humanos , Masculino , Pessoa de Meia-Idade
9.
Int J Mol Sci ; 22(17)2021 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-34502292

RESUMO

This is an attempt to make readers of the second edition of International Journal of Molecular Sciences Special Issue on the Barrier Function of Skin and Oral Mucosa aware of the content of the first edition on this same topic [...].


Assuntos
Permeabilidade da Membrana Celular , Mucosa Bucal/fisiologia , Pele/metabolismo , Humanos
10.
Int J Mol Sci ; 22(17)2021 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-34502305

RESUMO

Oral delivery of curcumin (CUR) has limited effectiveness due to CUR's poor systemic bioavailability caused by its first-pass metabolism and low solubility. Buccal delivery of CUR nanoparticles can address the poor bioavailability issue by virtue of avoidance of first-pass metabolism and solubility enhancement afforded by CUR nanoparticles. Buccal film delivery of drug nanoparticles, nevertheless, has been limited to low drug payload. Herein, we evaluated the feasibilities of three mucoadhesive polysaccharides, i.e., hydroxypropyl methylcellulose (HPMC), starch, and hydroxypropyl starch as buccal films of amorphous CUR-chitosan nanoplex at high CUR payload. Both HPMC and starch films could accommodate high CUR payload without adverse effects on the films' characteristics. Starch films exhibited far superior CUR release profiles at high CUR payload as the faster disintegration time of starch films lowered the precipitation propensity of the highly supersaturated CUR concentration generated by the nanoplex. Compared to unmodified starch, hydroxypropyl starch films exhibited superior CUR release, with sustained release of nearly 100% of the CUR payload in 4 h. Hydroxypropyl starch films also exhibited good payload uniformity, minimal weight/thickness variations, high folding endurance, and good long-term storage stability. The present results established hydroxypropyl starch as the suitable mucoadhesive polysaccharide for high-payload buccal film applications.


Assuntos
Quitosana/química , Curcumina/química , Sistemas de Liberação de Medicamentos , Derivados da Hipromelose/química , Mucosa Bucal/química , Nanopartículas/química , Amido/química , Anti-Inflamatórios não Esteroides/química , Quelantes/química , Portadores de Fármacos/química , Humanos , Solubilidade
12.
Medicina (Kaunas) ; 57(9)2021 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-34577888

RESUMO

Oral mucosal melanoma (OMM) represents an extremely rare entity that is associated with a poor prognosis due to late diagnosis and early metastasis. Here, extensive surgical therapy is the therapy of choice. In contrary, for OMM in situ, the respective therapeutical recommendations are lacking. In this case report, treatment modalities of an OMM in situ of the palate, including the maxillary alveolar process, are reported. The tumor relapsed twice despite adequate surgical therapy and reconstruction. Therefore, irradiation was performed as an adjuvant therapy. At a follow-up of two years, the patient was free from recurrences.


Assuntos
Melanoma , Neoplasias Bucais , Neoplasias Cutâneas , Humanos , Melanoma/cirurgia , Mucosa Bucal , Neoplasias Bucais/cirurgia , Recidiva Local de Neoplasia
13.
BMC Oral Health ; 21(1): 427, 2021 09 04.
Artigo em Inglês | MEDLINE | ID: mdl-34481467

RESUMO

BACKGROUND: Dental radiographs are essential tools for diagnosis. However, there are significant concerns about the dangerous effect of radiation especially on children. The aim of this study was to evaluate genotoxicity and cytotoxicity in the exfoliated cells of buccal mucosa of children subjected to Cone Beam Computed Tomography (CBCT). METHODS: The study included 18 healthy children aged (9-12 years) who were exposed to CBCT. All CBCT scans were performed with the i-CAT CBCT. Exfoliated buccal cells were scraped from the left and right cheek immediately before the exposure, after 10 ± 2 days, and after 1 month. Cells were stained using Feulgen/fast green stain and examined under light microscopy. Genotoxicity (Micronuclei) and cytotoxicity (condensed chromatin, karyorrhexis, pyknosis, and karyolysis) were scored. Statistical analysis was performed using the McNemar test, Wilcoxon Signed-Rank test, and Mann-Whitney U test at a significance level of p < 0.05. RESULTS: There were statistically significant differences in the mean percentages of micronuclei, condensed chromatin, karyorrhexis, pyknosis, and karyolysis before and 10 ± 2 days after the CBCT scan (p < 0.05). There were no statistically significant differences in the frequency of micronuclei, condensed chromatin, karyorrhexis, or pyknosis before and 1 month after the exposure (p > 0.05) except for karyolysis (p < 0.05). CONCLUSIONS: CBCT may induce genotoxicity and cytotoxicity in buccal mucosa cells of children. Therefore, CBCT should not be prescribed unless necessary as it cannot be considered a risk-free procedure.


Assuntos
Dano ao DNA , Mucosa Bucal , Morte Celular , Tomografia Computadorizada de Feixe Cônico , Testes para Micronúcleos
14.
BMJ Case Rep ; 14(9)2021 Sep 21.
Artigo em Inglês | MEDLINE | ID: mdl-34548295

RESUMO

Double lip or macrocheilitis is a rare facial anomaly, mostly congenital in origin. It commonly involves the upper lip than the lower lip. It may occur in isolation or as part of the Ascher's syndrome. It results due to deposition of excessive areolar tissue and non-inflammatory hyperplasia of labial mucosa gland of pars villosa. It may be acquired as a result of injury to the lips or lip-biting habit. The double lip becomes conspicuous when the lips are retracted during smiling resulting in the characteristic 'cupid's bow' appearance. This disfigurement can pose aesthetic and functional problems and may result in psychological distress. A surgical intervention is must for restoration of functions and to address the aesthetic concerns. The present article reports a case of non-syndromic double upper lip with triple labial frena and its surgical management with laser on one side and with scalpel on the other side.


Assuntos
Fenda Labial , Anormalidades da Boca , Procedimentos Cirúrgicos Reconstrutivos , Fenda Labial/cirurgia , Estética , Humanos , Lábio/cirurgia , Mucosa Bucal/cirurgia
15.
BMJ Case Rep ; 14(9)2021 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-34544699

RESUMO

Granular cell tumour (GCT) is a rare soft tissue lesion which many consider to have malignant potential of yet unknown aetiopathogenesis. Oral GCT lesions may occur in an area of leucoplakia and are predominantly present on the tongue. This case study highlights an uncommon presentation of this condition located on the buccal mucosa and illustrates the need for meticulous evaluation of suspicious lesions. Due to the malignant risk associated with GCT lesions, it is important to make the correct diagnosis and ensure complete surgical excision for these cases. Ongoing long-term follow-up is also indicated to monitor for recurrence or malignancy.


Assuntos
Tumor de Células Granulares , Neoplasias da Língua , Tumor de Células Granulares/diagnóstico por imagem , Tumor de Células Granulares/cirurgia , Humanos , Mucosa Bucal , Recidiva Local de Neoplasia , Língua
16.
Arch Oral Biol ; 131: 105250, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34482219

RESUMO

OBJECTIVES: The aim of this study was to analyze the effects of three different Photobiomodulation Therapy (PBMT) protocols in the treatment of 5-fluorouracil-induced oral mucositis in hamsters. DESIGN: 60 hamsters were divided into five groups: group "C", which did not receive oral mucosa scratching, 5-fluorouracil (5-FU) or PBMT; group "Ch", which received anesthesia, superficial oral mucosa scratching and 5-FU (oral mucositis induction); and three groups that received oral mucositis induction and a PBMT protocol: groups ChLI, ChLII and ChLIII that received 0.24 J (one point), 1 J (one point) and 1.2 J (five points of 0.24 J) of energy, respectively. The laser equipment used had λ = 660 nm and 0.04 cm2 of spot area (0.226 cm diameter). The animals were euthanized on days 7 and 10 of the experiment, and their oral mucosas were removed for histological (light microscopy and collagen staining), immunohistochemical (NF-kB and TNF-α), and biochemical (TNF-α, NF-kB and hydroxyproline) analysis. RESULTS: Group ChLI (less energy), showed the most accelerated repair rates and a lower concentration of inflammatory biomarkers than group Ch. Comparing the three PBMT protocols for treatment of 5-FU-induced oral mucositis in hamsters, the one with low energy (0.24 J) showed better results, regarding reduction of inflammatory biomarkers and tissue repair, than the ones with higher energy (1 and 1.2 J).


Assuntos
Terapia com Luz de Baixa Intensidade , Mucosite , Estomatite , Animais , Cricetinae , Fluoruracila , Mucosa Bucal , Estomatite/terapia , Cicatrização
17.
Arch Oral Biol ; 130: 105213, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34339966

RESUMO

OBJECTIVES: The aim of the present study was to review the existing phenomena which could affect subjective oral dryness and to consider the possibility that neural processing is involved in the perception of oral dryness. DESIGN: A comprehensive review of scientific literatures relevant to contributing factors of dry mouth symptoms including salivary parameters related with oral dryness and role of neural mechanisms in perception of dry mouth symptoms was conducted. RESULTS: Several previous reports suggested the possibility of neural processing mechanisms in perception of oral dryness. The decreased pain threshold in the oral cavity of rats with dry tongue and complaints of subjective oral dryness in patients with burning mouth syndrome, of which lacked an actual decrease in salivary output and mucosal wetness, could support this idea. Sensory changes in the oral mucosa and oral dryness may have a bi-directional influence that patients with oral dryness would be more subject to neuropathic pain in the oral mucosa, and those with neuropathic pain in the oral cavity could have complaints associated with higher levels of dry mouth symptoms. CONCLUSION: A bi-directional influence between sensory change in the oral mucosa and subjective oral dryness could be assumed. We suggest the administration of neuropathic pain medications for controlling subjective oral dryness in patients without objective sign of hyposalivation.


Assuntos
Síndrome da Ardência Bucal , Xerostomia , Animais , Humanos , Mucosa Bucal , Percepção , Ratos , Saliva
19.
Artigo em Russo | MEDLINE | ID: mdl-34460151

RESUMO

OBJECTIVE: To study clinical characteristics of burning mouth syndrome or glossalgia is a functional disorder with painful sensations in the oral cavity with verification of the psychopathological structure, typology and nosology of the syndrome within the continuum of neurotic/psychotic disorders and dermatological pathology, i.e. lichen planus (LP). MATERIAL AND METHODS: The study sample (n=30, 27 female, mean age 59.3±15.6 years) was examined by dermatologist, neurologist and psychiatrist both clinically and psychometrically. The patients met the diagnostic criteria for glossalgia according to the IASP classification and ICD-10 for glossodynia (code K14.6). In 7 subjects, there was comorbidity with LP of the oral mucosa. RESULTS: The psychopathological picture of glossalgia syndrome has a binary structure. Basic coenesthesiopathies, ranging in severity from homonomous sensations (isteralgias) to heteronomic sensopathies (senestopathies, senesthesia), are associated with secondary hypochondriacal phenomena: from health anxiety and monopatophobia to mastery of ideas and somatopsychic confusion, respectively. According to the psychopathological register (neurotic/psychotic) and the fact of objective verification of a dermatological disease (hypochondria sine materia/cum materia), there are three types of glossalgic syndrome: 1) organo-neurotic; 2) somatopsychotic; 3) dermatological (stress-induced somatic reactions). CONCLUSION: BMS is a local syndrome limited to the oral cavity, however, in fact, it covers the entire clinical spectrum of psychosomatic pathology from mental diseases to psychodermatological ones.


Assuntos
Síndrome da Ardência Bucal , Glossalgia , Síndrome da Ardência Bucal/diagnóstico , Feminino , Humanos , Hipocondríase , Pessoa de Meia-Idade , Mucosa Bucal , Transtornos Psicofisiológicos/diagnóstico
20.
Int J Mol Sci ; 22(15)2021 Jul 22.
Artigo em Inglês | MEDLINE | ID: mdl-34360589

RESUMO

The oral mucosa, which is the lining tissue of the oral cavity, is a gateway to the body and it offers first-line protection against potential pathogens, exogenous chemicals, airborne allergens, etc. by means of its physical and microbiological-immune barrier functions. For this reason, oral mucosa is considered as a mirror to the health of the individual as well as a guard or early warning system. It is organized in two main components: a physical barrier, which consists of stratified epithelial cells and cell-cell junctions, and a microbiological-immune barrier that keeps the internal environment in a condition of homeostasis. Different factors, including microorganism, saliva, proteins and immune components, have been considered to play a critical role in disruption of oral epithelial barrier. Altered mucosal structure and barrier functions results in oral pathologies as well as systemic diseases. About 700 kinds of microorganisms exist in the human mouth, constituting the oral microbiota, which plays a significant role on the induction, training and function of the host immune system. The immune system maintains the symbiotic relationship of the host with this microbiota. Crosstalk between the oral microbiota and immune system includes various interactions in homeostasis and disease. In this review, after reviewing briefly the physical barriers of oral mucosa, the fundamentals of oral microbiome and oral mucosal immunity in regard to their barrier properties will be addressed. Furthermore, their importance in development of new diagnostic, prophylactic and therapeutic strategies for certain diseases as well as in the application for personalized medicine will be discussed.


Assuntos
Homeostase , Imunidade nas Mucosas/imunologia , Microbiota , Mucosa Bucal/imunologia , Mucosa Bucal/microbiologia , Animais , Humanos
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