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1.
Psychiatr Hung ; 34(2): 160-171, 2019.
Artigo em Húngaro | MEDLINE | ID: mdl-31417005

RESUMO

In this early study, written in 1985, I examined six of the most important personality traits of Sylvia Plath, the poet and writer (1). Sylvia oscillated between positions of dependency and independence; she was characterised by sexual inhibition and promiscuity, writer's block and an explosion of writing, achievement con- straint and liberation from the constraint, emotional dependence and independence. Paradoxically, she committed suicide when far more things (children, productive creative period, publication of her novel) tied her to life than was the case before her first suicide attempt (2). Her life was spent in the perspective of death; death was her main point of reference, and at the same time was a constantly present alternative solution (3). Her neurasthenic, sometimes bipolar mode of existence determined her everyday behaviour: fatigue, irritability, a low ability to tolerate failure, a tendency to somatisation, anxious attitude, low self-esteem (4). She lived between extremes: insensitivity and over-sensitivity, bad and good moods, ego systole and ego diastole, ambivalence towards close family members (father, mother, Ted), relationship fluctuating between adoration and hate (5). Her poetry persona was characterised by object phobia: in her poems objects become hooks, loops, traps (6). She was ambivalent towards both women and men: she hated women, while her effective therapist was a woman; she was jealous of men, she was not capable of a symmetrical partner relationship, she was either subordinate or superior. In Plath's poetry the incompatible dichotomy of soft worm and hard mask refers to the irreconcilable contradiction between the male and female world.


Assuntos
Pessoas Famosas , Transtornos da Personalidade/história , Transtornos da Personalidade/psicologia , Personalidade , Feminino , História do Século XX , Humanos , Masculino , Núcleo Familiar/psicologia , Autoimagem , Suicídio/história , Suicídio/psicologia , Redação/história
2.
Sci Data ; 6(1): 91, 2019 06 14.
Artigo em Inglês | MEDLINE | ID: mdl-31201313

RESUMO

Single-molecule long-read sequencing datasets were generated for a son-father-mother trio of Han Chinese descent that is part of the Genome in a Bottle (GIAB) consortium portfolio. The dataset was generated using the Pacific Biosciences Sequel System. The son and each parent were sequenced to an average coverage of 60 and 30, respectively, with N50 subread lengths between 16 and 18 kb. Raw reads and reads aligned to both the GRCh37 and GRCh38 are available at the NCBI GIAB ftp site (ftp://ftp-trace.ncbi.nlm.nih.gov/giab/ftp/data/ChineseTrio/). The GRCh38 aligned read data are archived in NCBI SRA (SRX4739017, SRX4739121, and SRX4739122). This dataset is available for anyone to develop and evaluate long-read bioinformatics methods.


Assuntos
Grupo com Ancestrais do Continente Asiático/genética , Bases de Dados Genéticas , Genoma Humano , Núcleo Familiar , China , Feminino , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Masculino , Análise de Sequência de DNA
3.
Diabetes Res Clin Pract ; 152: 79-87, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31102683

RESUMO

AIMS: The present report aimed to clarify the clinical characteristics in a girl at the age of 12 and her mother with partial lipodystrophy and Type A insulin resistance syndrome. METHODS: We examined fat distribution in the patients using dual-energy X-ray absorptiometry, magnetic resonance imaging, and computed tomography. We performed genetic analysis to examine the causal gene for lipodystrophy and insulin resistance. RESULTS: Both patients had partial lipodystrophy and a novel heterozygous missense mutation (Asn1137 → Lys1137) in the insulin receptor gene. Because Asn1137 in the catalytic loop is conserved in all protein kinases, this mutation was thought to impair insulin receptor function. By whole-exome sequencing, we found the proband had neither mutations in candidate genes known to be associated with familial partial lipodystrophy nor novel likely candidate causal genes. Taken together, we thought that fat loss in these two patients might be caused by insulin receptor dysfunction. The proband had amenorrhea due to polycystic ovary syndrome. Her menstruation improved, as fat loss was restored during adolescence. This might be caused by improving insulin resistance due to increased levels of leptin and fat mass. CONCLUSIONS: This case might help to understand the mechanisms insulin receptor dysfunction that cause lipodystrophy.


Assuntos
Antígenos CD/genética , Lipodistrofia Parcial Familiar/genética , Síndrome Metabólica/genética , Mutação de Sentido Incorreto , Receptor de Insulina/genética , Adulto , Estudos de Casos e Controles , Criança , Feminino , Testes Genéticos , Heterozigoto , Humanos , Resistência à Insulina/genética , Lipodistrofia Parcial Familiar/complicações , Síndrome Metabólica/complicações , Pessoa de Meia-Idade , Núcleo Familiar , Linhagem , Fenótipo , Síndrome do Ovário Policístico/complicações , Síndrome do Ovário Policístico/genética
4.
BMC Public Health ; 19(1): 508, 2019 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-31054569

RESUMO

BACKGROUND: In Zambia, cervical cancer screening was started in 2006 and the human papillomavirus vaccine was piloted in 2013. Nevertheless, cervical cancer remains the leading cancer. It is assumed that knowledge, social interaction, health behaviors and religion are factors that can influence screening and vaccination practices. This study addresses the question, what is the relationship between knowledge about cervical cancer, attitudes, self-reported behavior, and immediate support system, towards screening and vaccination of cervical cancer of Zambian women and men. The results of this study serve as a basis for future research, an input for improvement and adjustment of the existing prevention program and build on documented health behavior frameworks. METHODS: A cross-sectional mixed methods study was conducted from February to May 2016. Two separate questionnaires were used to collect data from women (N = 300) and men (N = 300) residing in Chilenje and Kanyama (two townships in the capital city Lusaka). Respondent's knowledge of cervical cancer was operationalized by grading their ability to correctly identify causes and protective factors if they were aware of cervical cancer. Besides providing descriptive statistics of all study variables, we tested four research hypotheses concerning the link between knowledge, attitudes and practices suggested by the literature, by applying appropriate statistical tests (chi square test, analysis of variance, logistic regression). RESULTS: Less than half of the respondents (36.8%) had heard of cervical cancer, 20.7% of women had attended screening and 6.7% of the total sample had vaccinated their daughter. Knowledge of causes and prevention was very low. There was a strong association between having awareness of cervical cancer and practicing screening (odds ratio = 20.5, 95% confidence interval = [9.214, 45.516]) and vaccination (odds ratio = 5.1, 95% confidence interval = [2.473, 10.423]). Social interactions were also found to greatly influence screening and vaccination behaviors. CONCLUSIONS: The low level of knowledge of causes and prevention of cervical cancer suggests a need to increase knowledge and awareness among both women and men. Interpersonal interactions have great impact on practicing prevention behaviors, for instance, vaccination of daughters.


Assuntos
Detecção Precoce de Câncer , Conhecimentos, Atitudes e Prática em Saúde , Neoplasias do Colo do Útero , Adulto , Idoso , Estudos Transversais , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Núcleo Familiar , Vacinas contra Papillomavirus , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Inquéritos e Questionários , Neoplasias do Colo do Útero/etiologia , Neoplasias do Colo do Útero/prevenção & controle , Vacinação , Adulto Jovem , Zâmbia
5.
Arch Endocrinol Metab ; 63(3): 215-221, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31066762

RESUMO

OBJECTIVE: This study investigated the familial aggregation and heritability of markers of metabolic risk, physical activity, and physical fitness in nuclear families from Muzambinho (Minas Gerais, Brazil). SUBJECTS AND METHODS: The study included members of 139 families, comprising 97 fathers (aged 40 ± 7 years), 129 mothers (35 ± 6 years), 136 sons (12 ± 4 years), and 121 daughters (12 ± 5 years). Evaluated markers included (A) body mass index, waist circumference, glycemia, and cholesterolemia, as metabolic risk markers; (B) total weekly volume of physical activity, as a physical activity marker; and (C) relative muscle strength, as a physical fitness marker. Correlations between family members and heritability (h2) were estimated using the software S.A.G.E. RESULTS: Significant familial correlations were obtained between parents-offspring for glycemia and cholesterolemia (both ρ = 0.21, p < 0.05) and relative muscle strength (ρ = 0.23, p < 0.05), and between siblings for waist circumference, glycemia, total weekly volume of physical activity, and relative muscle strength (ρ variation 0.25 to 0.36, p < 0.05). Heritability values were significant for almost all variables (h2 variations: 20% to 57% for metabolic risk markers, 22% for the total weekly volume of physical activity, and 50% for relative muscle strength), except for waist circumference (h2 = 15%, p = 0.059). CONCLUSION: The presence of significant correlations between family members and/or significant heritability strengthens the possible genetic and/or common familial environment influence on metabolic risk markers, total weekly volume of physical activity, and relative muscle strength.


Assuntos
Exercício , Síndrome Metabólica/genética , Adolescente , Adulto , Biomarcadores , Composição Corporal , Índice de Massa Corporal , Brasil/epidemiologia , Doenças Cardiovasculares/epidemiologia , Doenças Cardiovasculares/genética , Criança , Exercício/fisiologia , Feminino , Predisposição Genética para Doença , Humanos , Masculino , Síndrome Metabólica/sangue , Síndrome Metabólica/epidemiologia , Pessoa de Meia-Idade , Força Muscular/fisiologia , Núcleo Familiar , Aptidão Física/fisiologia , Fatores de Risco , Circunferência da Cintura , Adulto Jovem
6.
EBioMedicine ; 42: 76-85, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30952617

RESUMO

BACKGROUND: Autoimmune disease prevention requires tools to assess an individual's risk of developing a specific disease. One tool is disease-associated autoantibodies, which accumulate in an asymptomatic preclinical period. However, patients sometimes exhibit autoantibodies associated with a different disease classification. When and how these alternative autoantibodies first appear remain unknown. This cross-sectional study characterizes alternative autoimmunity, and associated genetic and environmental factors, in unaffected first-degree relatives (FDRs) of patients, who exhibit increased future risk for the same disease. METHODS: Samples (n = 1321) from disease-specific autoantibody-positive (aAb+) systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and type 1 diabetes (T1D) patients; and unaffected aAb+ and autoantibody-negative (aAb-) SLE and RA FDRs were tested for SLE, RA, and T1D aAbs, as well as anti-tissue transglutaminase, anti-cardiolipin and anti-thyroperoxidase. FDR SLE and RA genetic risk scores (GRS) were calculated. FINDINGS: Alternative autoimmunity occurred in SLE patients (56%) and FDRs (57·4%), RA patients (32·6%) and FDRs (34·8%), and T1D patients (43%). Expanded autoimmunity, defined as autoantibodies spanning at least two other diseases, occurred in 18·5% of SLE patients, 16·4% of SLE FDRs, 7·8% of RA patients, 5·3% of RA FDRs, and 10·8% of T1D patients. SLE FDRs were more likely to have alternative (odds ratio [OR] 2·44) and expanded (OR 3·27) autoimmunity than RA FDRs. Alternative and expanded autoimmunity were associated with several environmental exposures. Alternative autoimmunity was associated with a higher RA GRS in RA FDRs (OR 1·41), and a higher SLE GRS in aAb+ RA FDRs (OR 1·87), but not in SLE FDRs. INTERPRETATION: Autoimmunity commonly crosses disease-specific boundaries in systemic (RA, SLE) and organ-specific (T1D) autoimmune diseases. Alternative autoimmunity is more common in SLE FDRs than RA FDRs, and is influenced by genetic and environmental factors. These findings have substantial implications for preclinical disease pathogenesis and autoimmune disease prevention studies. FUND: NIH U01AI101981, R01AR051394, U19AI082714, P30AR053483, P30GM103510, U54GM104938, U01AI101934, R01AI024717, U01AI130830, I01BX001834, & U01HG008666.


Assuntos
Artrite Reumatoide/etiologia , Autoimunidade/genética , Predisposição Genética para Doença , Lúpus Eritematoso Sistêmico/etiologia , Núcleo Familiar , Adulto , Idoso , Alelos , Artrite Reumatoide/diagnóstico , Autoanticorpos/imunologia , Meio Ambiente , Feminino , Frequência do Gene , Humanos , Lúpus Eritematoso Sistêmico/diagnóstico , Masculino , Pessoa de Meia-Idade , Especificidade de Órgãos/imunologia , Polimorfismo de Nucleotídeo Único , Fatores de Risco
7.
Aust N Z J Public Health ; 43(3): 261-266, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30830710

RESUMO

OBJECTIVE: Parental cancer is a significant problem for adolescent and young adult offspring. To understand the extent of the problem of parental cancer for Australian offspring, data regarding those impacted are required. The aim of this study was to enumerate and describe the characteristics of Western Australian adolescent and young adult offspring (12-24 years) and their parents with cancer using linked population data. METHODS: A retrospective cohort study was conducted using data from the Western Australia Data Linkage System, which provided results generalisable at a national level. RESULTS: Between 1982 and 2015, 57,708 offspring were impacted by 34,600 parents' incident malignant cancer diagnoses. The most common diagnosis was breast cancer. Of the 36.4% of parents who died, this was mostly a result of cancer. Most families resided in regional areas and were of high or middle socioeconomic status. Significant predictors of earlier parent death included low socioeconomic status, remoteness, age, having more children and having older children. CONCLUSION: A considerable number of adolescent and young adult offspring are impacted by parental cancer at a potentially vulnerable age. This research provides knowledge to better understand who is affected by parental cancer in Australia. Implications for public health: These results may be useful for planning and implementation of Australian supportive services.


Assuntos
Crianças Adultas/psicologia , Neoplasias/epidemiologia , Neoplasias/psicologia , Núcleo Familiar/psicologia , Pais , Adolescente , Austrália , Criança , Feminino , Humanos , Incidência , Masculino , Neoplasias/mortalidade , Vigilância da População , Modelos de Riscos Proporcionais , Estudos Retrospectivos , Classe Social , Austrália Ocidental/epidemiologia , Adulto Jovem
9.
JAMA ; 321(10): 941-942, 2019 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-30860563
10.
Cultur Divers Ethnic Minor Psychol ; 25(1): 65-72, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30714768

RESUMO

OBJECTIVES: Recently, there has been a call to better understand Latino health and arrive at effective approaches for achieving health equity via research focusing on the association between cultural factors and health. This study examined whether familism, a cultural value that emphasizes warm and close family relationships, would attenuate the negative effects that perceived stress, a psychological process that can worsen health, can have on two physical health indicators- number of health conditions and bodily pain. METHOD: Latina mothers (n = 85, Mage = 52.68, SD = 6.60) with Type 2 diabetes and their daughters (n = 86, Mage = 27.69, SD = 7.61) whose weight put them at risk for also developing the condition were recruited to take part in a larger intervention study aimed at improving weight loss/dietary intake. Participants completed measures of familism, perceived stress, health conditions, and bodily pain. RESULTS: Results indicated that in the daughters, familism and perceived stress interacted to predict health conditions and bodily pain. As familism decreased, stress was associated with more health conditions and more bodily pain. These interactions were not significant for the mothers. CONCLUSIONS: First, familism has the potential to buffer the negative effect of stress in ways that are protective for health among Latinas at risk for diabetes. Second, this buffering effect has boundary conditions, suggesting that a better understanding is needed of how, for whom, and under what circumstances familism can be beneficial for health. (PsycINFO Database Record (c) 2019 APA, all rights reserved).


Assuntos
Diabetes Mellitus Tipo 2/psicologia , Relações Familiares/psicologia , Equidade em Saúde , Hispano-Americanos/psicologia , Relações Mãe-Filho/psicologia , Núcleo Familiar/psicologia , Adulto , Diabetes Mellitus Tipo 2/etnologia , Diabetes Mellitus Tipo 2/prevenção & controle , Relações Familiares/etnologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Relações Mãe-Filho/etnologia , Mães , Apoio Social , Adulto Jovem
12.
Proc Natl Acad Sci U S A ; 116(6): 2039-2041, 2019 02 05.
Artigo em Inglês | MEDLINE | ID: mdl-30670653

RESUMO

Gender inequality starts early in life. Parents tend to prefer boys over girls, which is manifested in reproductive behavior, marital life, and parents' pastimes and investments in their children. While social media and sharing information about children (so-called "sharenting") have become an integral part of parenthood, whether and how gender preference shapes the online behavior of users are not well known. In this paper we use public posts made by 635,665 users from Saint Petersburg on a popular Russian social networking site, to investigate public mentions of daughters and sons on social media. We find that both men and women mention sons more often than daughters in their posts. We also find that posts featuring sons receive more "likes" on average. Our results indicate that girls are underrepresented in parents' digital narratives about their children, in a country with an above-average ranking on gender parity. This gender imbalance may send a message that girls are less important than boys or that they deserve less attention, thus reinforcing gender inequality from an early age.


Assuntos
Identidade de Gênero , Núcleo Familiar , Pais/psicologia , Mídias Sociais , Fatores Socioeconômicos , Coleta de Dados , Características da Família , Feminino , Humanos , Masculino , Federação Russa , Fatores Sexuais , Comportamento Sexual , Comportamento Social
13.
Paediatr Perinat Epidemiol ; 33(2): 129-136, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30663124

RESUMO

BACKGROUND: Some cardiovascular disease risk factors are associated with both risk of preeclampsia and having been born to a younger or older mother. We examined whether mother's age at delivery predicts a primiparous daughter's risk of preeclampsia. METHODS: The analysis included 39 803 Sister Study participants (designated as "daughters") born between 1930 and 1974. Using log-binomial regression, we estimated relative risks (RR) of preeclampsia in the first pregnancy ending in birth ("primiparous preeclampsia") associated with mother's age at the daughter's birth. Models included: number of older full and maternal half-siblings, income level growing up, daughter's age at delivery, race/ethnicity, and 5-year birth cohort. We examined self-reported relative weight at age 10 (heavier than peers versus not) as a potential effect measure modifier. RESULTS: Overall, 6.2% of daughters reported preeclampsia. Compared with those who had been born to 20-24-year old mothers, daughters of teenage mothers had a relative risk of 1.20 (95% confidence interval (CI) 1.01, 1.43) and daughters of mothers ≥25 had a ~10% lower risk. Relative weight at age 10 modified the association, with an inverse association between mother's age at delivery and preeclampsia seen only among daughters with low/normal childhood relative weight. In this subset, results were consistent across strata of daughter's age at menarche and age at first birth. CONCLUSIONS: These findings, based on self-reported data, require replication. Nevertheless, as women increasingly delay childbearing, they provide some reassurance that having been born to an older mother is not, per se, a risk factor for primiparous preeclampsia.


Assuntos
Predisposição Genética para Doença/epidemiologia , Idade Materna , Núcleo Familiar , Pré-Eclâmpsia/epidemiologia , Adulto , Idoso , Estudos de Coortes , Feminino , Humanos , Pessoa de Meia-Idade , Gravidez , Risco , Irmãos
14.
J Consult Clin Psychol ; 87(3): 294-307, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30640483

RESUMO

OBJECTIVE: To increase girls' well-being, strategies are needed to optimize their social-emotional competence during childhood. Although positive fathering is important for girls, many fathers discount their unique influence and few participate in interventions. The Dads And Daughters Exercising and Empowered (DADEE) program was developed to engage fathers and their daughters through shared physical activity experiences. This study examined the program's impact on girls' well-being and the father-daughter relationship. METHOD: Overall, 115 fathers (age range: 29-53 years) and 153 daughters (age range: 4-12 years) were randomized to (1) the DADEE program (9 weekly educational and practical sessions plus home-based challenges) or (2) a wait-list control. Assessments were baseline, 2 months (postintervention), and 9 months (94% retention). Daughters' social-emotional well-being was measured with the Devereux Student Strengths Assessment composite. Secondary outcomes included additional well-being indicators (e.g., global self-perception) plus validated measures of father involvement and father-daughter relationship quality. RESULTS: At 2 months, intervention daughters showed a medium-to-large improvement in overall well-being (+24.9 units, 95% CI [8.6, 41.1], d = 0.6), when compared with controls. Intervention daughters were also more likely to show clinically meaningful improvements in well-being (54%) than controls (18%). Medium-to-large effects were observed for: seven of eight social-emotional competencies (e.g., personal responsibility, d = 0.4-0.9), father-daughter relationship quality (d = 0.8, father-report; d = 0.5, daughter-report), daughters' prosocial behavior (d = 0.3) and several indicators of father involvement. Most outcomes had improved by 9 months. No effects were observed for daughters' emotional difficulties or global self-perception. CONCLUSIONS: This study provided the first experimental evidence that father-daughter physical activity programs may improve girls' well-being and the father-daughter relationship. (PsycINFO Database Record (c) 2019 APA, all rights reserved).


Assuntos
Emoções/fisiologia , Exercício/psicologia , Pai , Núcleo Familiar/psicologia , Satisfação Pessoal , Autoimagem , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Comportamento Social
15.
Medicine (Baltimore) ; 98(2): e13922, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30633165

RESUMO

RATIONALE: Complex pulmonary arteriovenous fistula (PAVF) is unusual, and even rarer in 2 members of a family. PAVF may not appear on chest X-ray or computed tomography imaging, especially in asymptomatic patients, and therapy is limited. Herein, PAVFs occurring in a mother and daughter are described, with the current standard methods of diagnosis and treatment of PAVF. PATIENT CONCERNS: A 34-year-old woman and her 13-year-old daughter presented with light cyanosis of the nail beds but were otherwise asymptomatic, and physical examination was unremarkable. Their arterial oxygen saturation levels were low (80-85%). DIAGNOSES: Angiography led to a diagnosis of PAVF involving the bilateral lung in both women. INTERVENTIONS: The combined use of coils with occluder (patent ductus arteriosus, or PDA) to obstruct the fistula. OUTCOMES: After interventional treatment, the patients' arterial oxygen saturation improved rapidly (90-95%). At 6-month follow-up, the patients' symptoms and oxygen saturation were normal. LESSONS: PAVF is an autosomal dominant disease. Here, the characteristics of the 2 patients were very similar. Using detachable coils and then a PDA occluder is a highly efficient method for treating complex PAVFs.


Assuntos
Fístula Arteriovenosa/diagnóstico , Fístula Arteriovenosa/terapia , Artéria Pulmonar/anormalidades , Veias Pulmonares/anormalidades , Adolescente , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Núcleo Familiar
17.
Fertil Steril ; 111(2): 381-388, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30527840

RESUMO

OBJECTIVE: To study the reproductive and metabolic differences between daughters of women with polycystic ovary syndrome (PCOSd) and control women (Cd) after menarche. DESIGN: Case-control study. SETTING: Clinical endocrinology unit. PATIENT(S): We studied 43 PCOSd and 28 Cd 1.5-6 years after menarche. INTERVENTION(S): Determination of anthropometry, pubertal development, hirsutism, oral glucose tolerance test, and GnRH analogue test. MAIN OUTCOME MEASURE(S): Ferriman score, sex steroids, gonadotropins, antimüllerian hormone (AMH), ovarian volumes, and glucose and insulin levels. RESULT(S): The groups were similar in chronologic, gynecologic, and menarchal ages and anthropometric variables. Ferriman score, ovarian volumes, and AMH were higher in PCOSd. Propensity score analysis showed that there were significant differences in LH, LH-FSH ratio, T and free androgen index, post-stimulated LH and LH-FSH ratio, and 2-hour insulin that could be attributed only to the fact of being a PCOS daughter. The generalized linear model showed that higher LH levels were positively associated with AMH and T levels. CONCLUSION(S): We found that higher LH, androgen, and insulin levels are present in PCOSd during the postmenarchal period, which may establish the basis for the development of PCOS during adulthood. Moreover, LH levels were associated with AMH levels, which supports that the neuroendocrine feedback proposed for AMH and LH is present in humans and that this feature is probably programed in utero, as recently shown in mice.


Assuntos
Hormônio Antimülleriano/sangue , Hormônio Luteinizante/sangue , Menarca/sangue , Núcleo Familiar , Ovário/metabolismo , Síndrome do Ovário Policístico/sangue , Adolescente , Fatores Etários , Biomarcadores/sangue , Estudos de Casos e Controles , Criança , Feminino , Predisposição Genética para Doença , Humanos , Insulina/sangue , Menarca/genética , Ovário/diagnóstico por imagem , Ovário/fisiopatologia , Fenótipo , Síndrome do Ovário Policístico/diagnóstico , Síndrome do Ovário Policístico/genética , Síndrome do Ovário Policístico/fisiopatologia , Fatores de Risco
18.
Public Health Nurs ; 36(2): 134-143, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30548324

RESUMO

OBJECTIVE: To increase our understanding about the health beliefs of African-American parents and their daughters toward HPV infection and HPV vaccine acceptance. METHODS: The Health Belief Model was used as a guiding framework. Principles of grounded theory, theoretical sampling, and constant comparison analysis were used to qualitatively analyze data generated from personal interviews of African-American parents (n = 30) and their 12- to 17-year-old daughters (n = 34). RESULTS: Mothers and daughters perceived low susceptibility to HPV infection and perceived the HPV vaccine as beneficial in protecting against genital warts and cervical cancer. Compared to daughters, parents placed particular emphasis on the vaccine's protection against genital warts. A major HPV vaccine acceptance barrier among parents and daughters was the politicization of the HPV vaccine by government figures. In addition, concerns about unknown side effects, safety, and effectiveness of HPV vaccination emerged. Cues to action varied among parents and daughters, and self-efficacy was higher among parents than daughters. CONCLUSION: Understanding the health beliefs that promote HPV vaccine acceptance, while identifying and addressing beliefs that are barriers among parents and daughters, will assist in the development of appropriate HPV vaccine promotion initiatives for African-American parents and daughters.


Assuntos
Afro-Americanos/psicologia , Conhecimentos, Atitudes e Prática em Saúde , Infecções por Papillomavirus/prevenção & controle , Vacinas contra Papillomavirus/administração & dosagem , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Vacinação/psicologia , Adolescente , Adulto , Criança , Feminino , Humanos , Mães , Núcleo Familiar , Pais , Autoeficácia , Neoplasias do Colo do Útero/prevenção & controle
20.
Artigo em Inglês | MEDLINE | ID: mdl-30577626

RESUMO

Both maternal pre-pregnancy body mass index (BMI) and gestational weight gain have been associated with cardiovascular health in the offspring beyond two generations. A total of 274 daughters (aged 12⁻54) of 208 mothers who participated in the Bogalusa Heart Study were interviewed about their reproductive history. Mothers' data was taken from the original study, and cardiovascular measures at the visit prior to pregnancy were correlated with daughter's measures. Maternal pre-pregnancy BMI, skinfold, and waist circumference were examined as a predictor of daughters' blood pressure, lipids, and glucose, as well as a predictor of birthweight and gestational age of grandchildren. Maternal pre-pregnancy BMI was associated with higher blood pressure and lower low-density lipoprotein (LDL) and cholesterol in the daughters. Most maternal cardiometabolic risk factors were not associated with grandchildren's birth outcomes, even though higher cholesterol and LDL was associated with lower gestational age, and higher BMI and skinfold thickness with an increased risk of preterm birth. In this pilot study, some associations were found between maternal adiposity and cardiovascular risk, daughters' cardiovascular risk, and grandchild birth outcomes. Lack of conclusive associations could be due to a true lack of effect, effects being primarily mediated through daughter's BMI, or the low power of the study.


Assuntos
Doenças Cardiovasculares/epidemiologia , Saúde da Família/estatística & dados numéricos , Adolescente , Adulto , Doenças Cardiovasculares/sangue , Criança , Feminino , Humanos , Pessoa de Meia-Idade , Mães , Núcleo Familiar , Projetos Piloto , Gravidez , Fatores de Risco , Adulto Jovem
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