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1.
Ann Thorac Surg ; 110(1): e67-e69, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-32114051

RESUMO

Sleeve resection and double-barreled reconstruction are very rarely adopted for peripheral bronchial tumors. This surgical procedure was used for a carcinoid tumor in the bifurcation of the left upper and lower lobe bronchi. Bronchoplasty was accomplished by suturing the upper and basal bronchi together and anastomosing them to the left main bronchus. The techniques for double-barreled reconstruction described in this report obtained a successful result. These manipulations may be applicable to resection of other bronchial and tracheal bifurcations.


Assuntos
Brônquios/cirurgia , Neoplasias Brônquicas/cirurgia , Tumor Carcinoide/cirurgia , Pneumonectomia/métodos , Procedimentos Cirúrgicos Reconstrutivos/métodos , Procedimentos Cirúrgicos Torácicos/métodos , Brônquios/diagnóstico por imagem , Neoplasias Brônquicas/diagnóstico , Broncoscopia , Tumor Carcinoide/diagnóstico , Feminino , Humanos , Pessoa de Meia-Idade
2.
Ann Thorac Surg ; 109(5): e383-e385, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-31981496

RESUMO

Thoracoscopic sleeve lobectomy is challenging, considering the technical difficulty in controlling the needle angle and thread through the port. However, effective simulation of the procedure remains to be established. Here, we describe our first experience with thoracoscopic sleeve lobectomy simulation using a three-dimensional printed thoracic model and a handmade rolled sponge. Owing to the transparent structure, we could simultaneously confirm the suturing technique through the monitor (two-dimensional) and direct vision (three-dimensional). We are certain that our realistic and easily repeatable simulation will assist in developing better technique and conduct feasible thoracoscopic sleeve lobectomy.


Assuntos
Neoplasias Brônquicas/cirurgia , Modelos Anatômicos , Pneumonectomia/educação , Pneumonectomia/métodos , Treinamento por Simulação , Toracoscopia/educação , Toracoscopia/métodos , Idoso , Anastomose Cirúrgica/métodos , Brônquios/patologia , Brônquios/cirurgia , Neoplasias Brônquicas/patologia , Feminino , Humanos , Técnicas de Sutura/educação
3.
BMC Pulm Med ; 19(1): 151, 2019 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-31474222

RESUMO

BACKGROUND: Myelolipoma is a rare benign tumor composed of mature adipose and hematopoietic tissues. Most myelolipomas are found in the adrenal glands, whereas intrathoracic myelolipoma is extremely rare. In particular, bronchial myelolipoma without the involvement of lung parenchyma has never been reported. CASE PRESENTATION: A previously healthy 38-year-old male developed dyspnea and a productive cough. Computed tomography revealed an endobronchial mass at the right bronchus intermedius and subsequent atelectasis of the right middle and lower lobes. Flexible bronchoscopy found a total obstruction of the right bronchus intermedius due to an endobronchial tumor. Using a rigid bronchoscope, the endobronchial tumor was resected and the base of the tumor was additionally ablated with a diode laser to prevent recurrence. The removed endobronchial tumor was a 13 mm × 20 mm-sized oval-shaped mass and was pathologically diagnosed as bronchial myelolipoma. Chest radiographs, obtained on the day following the procedure, showed an improvement of atelectasis, and accompanying symptoms were immediately improved. Follow-up bronchoscopy performed after 12 months evidenced no recurrence of the bronchial myelolipoma. CONCLUSIONS: We used bronchoscopic intervention in patients with solitary bronchial myelolipoma and there was no evidence of recurrence.


Assuntos
Neoplasias Brônquicas/patologia , Neoplasias Brônquicas/cirurgia , Mielolipoma/patologia , Mielolipoma/cirurgia , Adulto , Broncoscopia , Humanos , Terapia a Laser/métodos , Masculino , Tomografia Computadorizada por Raios X
4.
J Bras Pneumol ; 45(5): e20180140, 2019 Sep 16.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31531614

RESUMO

OBJECTIVE: To analyze determinants of prognosis in patients with bronchial carcinoid tumors treated surgically and the potential concomitance of such tumors with second primary neoplasms. METHODS: This was a retrospective analysis of 51 bronchial carcinoid tumors treated surgically between 2007 and 2016. Disease-free survival (DFS) was calculated by the Kaplan-Meier method, and determinants of prognosis were evaluated. Primary neoplasms that were concomitant with the bronchial carcinoid tumors were identified by reviewing patient charts. RESULTS: The median age was 51.2 years, 58.8% of the patients were female, and 52.9% were asymptomatic. The most common histology was typical carcinoid (in 80.4%). Five-year DFS was 89.8%. Ki-67 expression was determined in 27 patients, and five-year DFS was better among the patients in whom Ki-67 expression was ≤ 5% than among those in whom it was > 5% (100% vs. 47.6%; p = 0.01). Concomitant primary neoplasms were observed in 14 (27.4%) of the 51 cases. Among the concomitant primary neoplasms that were malignant, the most common was lung adenocarcinoma, which was observed in 3 cases. Concomitant primary neoplasms were more common in patients who were asymptomatic and in those with small tumors. CONCLUSIONS: Surgical resection is the mainstay treatment of bronchopulmonary carcinoid tumors and confers a good prognosis. Bronchial carcinoid tumors are likely to be accompanied by second primary neoplasms.


Assuntos
Neoplasias Brônquicas/cirurgia , Tumor Carcinoide/cirurgia , Segunda Neoplasia Primária/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Neoplasias Brônquicas/patologia , Tumor Carcinoide/patologia , Intervalo Livre de Doença , Feminino , Humanos , Antígeno Ki-67/análise , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Segunda Neoplasia Primária/patologia , Estudos Retrospectivos , Estatísticas não Paramétricas , Fatores de Tempo , Adulto Jovem
8.
BMJ Case Rep ; 12(5)2019 May 08.
Artigo em Inglês | MEDLINE | ID: mdl-31068348

RESUMO

A 45-year-old man presents with acute respiratory failure. Imaging revealed a left mainstem endobronchial mass with subcarinal lymphadenopathy, but no other evidence of a primary tumour. An incidental laryngeal nodule was found during bronchoscopy. Biopsies of this lesion by nasopharyngoscopy and subcarinal lymph nodes via mediastinoscopy were performed. Histopathological and immunohistochemical examination showed evidence of melanoma in both samples. Mutational analysis identified the presence of a BRAFV600E mutation. The patient underwent bronchoscopic ablation of the left mainstem endobronchial tumour with laser therapy followed by initiation of encorafenib and binimetinib combination therapy. The patient remains alive at 4 months after initial presentation of disease. This case adds to the body of literature highlighting the clinical heterogeneity and challenges of the management of metastatic pulmonary melanoma. To the best of our knowledge, this simultaneous constellation of metastasis has not been described before.


Assuntos
Neoplasias Brônquicas/secundário , Neoplasias Laríngeas/secundário , Terapia a Laser , Metástase Linfática/patologia , Neoplasias do Mediastino/secundário , Melanoma/patologia , Biópsia por Agulha , Neoplasias Brônquicas/diagnóstico por imagem , Neoplasias Brônquicas/cirurgia , Broncoscopia , Análise Mutacional de DNA , Humanos , Imuno-Histoquímica , Neoplasias Laríngeas/diagnóstico por imagem , Neoplasias Laríngeas/cirurgia , Linfadenopatia , Metástase Linfática/diagnóstico por imagem , Masculino , Neoplasias do Mediastino/diagnóstico por imagem , Neoplasias do Mediastino/cirurgia , Melanoma/diagnóstico por imagem , Melanoma/cirurgia , Pessoa de Meia-Idade , Resultado do Tratamento
9.
Interact Cardiovasc Thorac Surg ; 29(4): 638-640, 2019 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-31115440

RESUMO

Bronchoplasty is frequently required for radical resection of central typical carcinoid tumours. As sleeve bronchoplasty can be a complex procedure, an accurate evaluation of the tumour location is mandatory. Although the endobronchial part of the tumour can be easily evaluated by bronchoscopy, the exo-bronchial part is difficult to analyse with a standard computed tomography (CT) scan. A three-dimensional (3D) CT scan could be used to identify this exo-bronchial component of the tumour when planning a reconstruction. Herein, we present a case of a 59-year-old woman with a typical central carcinoid tumour of the right main bronchus. After 3D modelling, we successfully performed a total parenchyma-sparing resection with an intermedius bronchus reimplantation into the carina associated with the right upper bronchus anastomosis in the lateral trachea. The follow-up was uneventful. An endoscopy at 3 months showed excellent results.


Assuntos
Neoplasias Brônquicas/diagnóstico por imagem , Neoplasias Brônquicas/cirurgia , Tumor Carcinoide/diagnóstico por imagem , Tumor Carcinoide/cirurgia , Cirurgia Assistida por Computador , Procedimentos Cirúrgicos Torácicos , Anastomose Cirúrgica , Humanos , Imageamento Tridimensional , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Reconstrutivos , Tomografia Computadorizada por Raios X , Traqueia/cirurgia
10.
Can Respir J ; 2019: 5269728, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30937111

RESUMO

Background and Aim: Endobronchial benign tumors are a rarely seen clinical entity but may cause significant symptoms. Endobronchial treatment has the potential for relieving symptoms while saving the patient from invasive surgical procedures. No trials have been published that present and compare the various endobronchial treatment modalities for endobronchial benign tumors. The aim of the present study is to define safety and efficacy of endobronchial treatment in patients with benign endobronchial tumors from the point of complications and success rate. Methods: This study is a retrospective cohort study from a review of medical charts. Eligibility criteria included diagnosis of a benign endobronchial tumor. Our institution's bronchoscopy and pathology database was searched for specific benign tumors, and the results were further detailed based on the endobronchial location. Results: Forty-four patients with pathologically confirmed benign endobronchial tumors were included. Tumor regression was achieved in all patients with diode laser and argon plasma coagulation in combination with or without cryotherapy and without any major complication. There were no significant differences between the use of either diode laser or of argon plasma coagulation as a modality with immediate effect from the occurrence of residual tissue that needed cryotherapy (P > 0.05). There were no major complications. Eight patients had minor complications including minor bleeding (6 patients) and hypertension (2 patients) that were controlled medically. Thirty-one patients (70%) had very good response, and 13 patients (30%) had good response as defined in literature before. Conclusion: Diode laser and argon plasma coagulation in combination with or without cryotherapy are safe and effective methods for endobronchial treatment of benign endobronchial tumors.


Assuntos
Neoplasias Brônquicas/cirurgia , Broncoscopia/estatística & dados numéricos , Neoplasias da Traqueia/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Coagulação com Plasma de Argônio , Broncoscopia/métodos , Criança , Pré-Escolar , Crioterapia , Feminino , Humanos , Lasers de Estado Sólido/uso terapêutico , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Adulto Jovem
11.
Int J Surg Pathol ; 27(6): 584-592, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30898020

RESUMO

Primary pulmonary acinic cell carcinoma (ACC) is rare. The clinicopathological features are not identical to that of classic ACC that leads to misdiagnosis. In this article, we summarized the clinicopathological features of 25 such cases, including 6 cases in this series and additional 19 cases in the literature. Pulmonary ACCs showed an overwhelming solid growth pattern. The neoplastic cells had eosinophilic granular and clear cytoplasm in most cases and displayed basophilic cytoplasm in only 4 cases. Intratumoral fibrous septa, mitotic figure, necrosis, and psammoma bodies were observed in some cases. Prominent nuclear atypia and perineural invasion might suggest high-grade transformation, metastasis, and recurrence. The tumor cells were strongly positive for CK8/18 and negative for TTF-1, p63, S-100, mammaglobin, MUC5b, MUC5ac, and DOG1. CK7 was exclusively positive for neoplastic cells with ductal differentiation. Of the 25 included cases, 10 cases were initially misdiagnosed. The tumor was prone to involve the right bronchus. The patient outcome was favorable. The accurate diagnosis of primary pulmonary ACC relies on comprehensive evaluation of histological and immunohistochemical features and realization of the difference from classic ACC.


Assuntos
Biomarcadores Tumorais/metabolismo , Brônquios/patologia , Neoplasias Brônquicas/diagnóstico , Carcinoma de Células Acinares/diagnóstico , Células Acinares/patologia , Adolescente , Adulto , Neoplasias Brônquicas/mortalidade , Neoplasias Brônquicas/cirurgia , Carcinoma de Células Acinares/mortalidade , Carcinoma de Células Acinares/cirurgia , Criança , Diagnóstico Diferencial , Erros de Diagnóstico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pneumonectomia , Prognóstico , Resultado do Tratamento , Adulto Jovem
12.
Kyobu Geka ; 72(2): 160-163, 2019 Feb.
Artigo em Japonês | MEDLINE | ID: mdl-30772886

RESUMO

A 45-year-old woman, who had been treated for bronchial asthma, was referred to our hospital with symptoms of dyspnea. Upon examination, we found the right main bronchus to be almost completely occluded by an endobronchial tumor. For the purpose of diagnosis and relieving the dyspnea, we performed a rigid bronchoscopic tumor resection with a high frequency snare. The tumor was pathologically diagnosed as a typical bronchial carcinoid, and a right upper lobectomy and wedge resection of the right main bronchus was carried out 1 month later.


Assuntos
Neoplasias Brônquicas/cirurgia , Broncoscopia , Tumor Carcinoide/cirurgia , Asma/complicações , Brônquios/cirurgia , Neoplasias Brônquicas/complicações , Neoplasias Brônquicas/diagnóstico , Tumor Carcinoide/complicações , Tumor Carcinoide/diagnóstico , Feminino , Humanos , Pessoa de Meia-Idade
13.
BMC Surg ; 19(1): 13, 2019 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-30704440

RESUMO

BACKGROUND: Angiolipoma is a rare, benign tumor that primarily develops in the limbs and trunk. The occurrence of angiolipoma in the lungs is extremely rare; to date, only two cases of primary bronchial angiolipoma have been reported. Here, we report a case of angiolipoma of the right bronchus intermedius that was successfully treated with sleeve resection and reconstructive surgery. CASE PRESENTATION: This report presents a case of angiolipoma that developed in the right bronchus intermedius of a 68-year-old man. A chest CT revealed a 10-mm endobronchial mass that was clearly visible as a high-attenuation area of contrast enhancement. Bronchoscopy revealed a submucosal tumor on the anterior wall of the entrance to the right bronchus intermedius that was constricting the airway lumen. The tumor surface was covered with numerous engorged blood vessels, and the middle and inferior pulmonary lobes were intact. Bronchial sleeve resection of the right bronchus intermedius was performed. Histologically, a mixture of proliferating blood vessels and adipocytes were observed within the bronchus wall. Therefore, the pathological diagnosis was angiolipoma. Lung function was preserved, and complete resection of the tumor was achieved. At present (2 years and 7 months after surgery), the patient is recurrence-free. CONCLUSION: Accordingly, using bronchial sleeve resection and end-to-end anastomosis techniques, we accomplished complete tumor excision and avoided the need to resect additional lung parenchyma. Our procedure preserved pulmonary function and yielded a curative result. Bronchoscopic intervention or minimal parenchymal resection should be considered as treatments for bronchial angiolipoma. Given the small number of reports of bronchial angiolipoma, the collection of additional data is important to elucidate the clinical characteristics of this rare tumor.


Assuntos
Angiolipoma/cirurgia , Neoplasias Brônquicas/cirurgia , Pneumonectomia/métodos , Idoso , Angiolipoma/diagnóstico , Brônquios/diagnóstico por imagem , Brônquios/cirurgia , Neoplasias Brônquicas/diagnóstico , Broncoscopia , Humanos , Masculino , Procedimentos Cirúrgicos Reconstrutivos , Tomografia Computadorizada por Raios X
14.
BMC Pulm Med ; 19(1): 41, 2019 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-30767776

RESUMO

BACKGROUND: Pulmonary carcinoids are included in the group of neuroendocrine tumors (NET) and derive from pulmonary neuroendocrine cells. The incidence of these tumors is increasing, but disease awareness remains low among clinicians. The synchronous presentation of lung cancer and mycobacterial infection is well known but the combination of pulmonary carcinoid and mycobacterial infection is rare. CASE PRESENTATION: We treated a 45-year-old female who presented with recurrent pneumonia. Chest X-ray showed a consolidation in the left upper lobe. The patient was treated with various courses of antibiotics without full recovery after six months. Computed tomography (CT) scan demonstrated a central mass in the left upper lobe. Bronchoscopy revealed an endobronchial, well-defined lesion that totally obstructed the left upper lobe bronchus. Bronchial biopsy showed typical carcinoid tumor. Rigid bronchoscopy with electrocautery was attempted, but we were unable to radically remove the tumor. Therefore lobectomy was performed. The surgical pathology specimen showed atypical bronchial carcinoid and consolidations in the lung parenchyma with granulomatous inflammation distally of the bronchial obstruction. Ziehl-Neelsen staining demonstrated acid fast bacilli indicative of mycobacterial infection. CONCLUSIONS: This case history illustrates the importance of careful surgical pathologic examination, not only of the resected tumor, but also of the postobstructive lung parenchyma. Specific postobstructive infections such as tuberculosis or nontuberculous mycobacteria (NTM) can have clinical implications.


Assuntos
Obstrução das Vias Respiratórias/patologia , Neoplasias Brônquicas/patologia , Tumor Carcinoide/patologia , Infecções por Mycobacterium/patologia , Pneumonia Bacteriana/patologia , Obstrução das Vias Respiratórias/etiologia , Biópsia , Neoplasias Brônquicas/complicações , Neoplasias Brônquicas/diagnóstico por imagem , Neoplasias Brônquicas/cirurgia , Broncoscopia , Tumor Carcinoide/complicações , Tumor Carcinoide/diagnóstico por imagem , Tumor Carcinoide/cirurgia , Feminino , Humanos , Pulmão/patologia , Pessoa de Meia-Idade , Mycobacterium , Infecções por Mycobacterium/complicações , Pneumonectomia , Pneumonia Bacteriana/complicações , Tomografia Computadorizada por Raios X
15.
BMC Pulm Med ; 19(1): 44, 2019 Feb 18.
Artigo em Inglês | MEDLINE | ID: mdl-30777035

RESUMO

BACKGROUND: Postpneumonectomy-like syndrome is a rare condition resulting from unilateral lung disease with severe lung volume loss leading to excessive mediastinal shift and herniation of the healthy lung into the contralateral hemithorax, mimicking the mediastinal shift observed in postpneumonectomy syndrome after pneumonectomy. We report a unique case of postpneumonectomy-like syndrome caused by an atypical bronchial carcinoid completely occluding the left main bronchus. CASE PRESENTATION: A 25-year-old woman presented with symptoms of chronic exertional dyspnea and productive cough. Imaging studies showed complete left lung atelectasis due to a mass occluding the left main bronchus, as well as extreme mediastinal deviation and substantial herniation of the right lung into the left hemithorax. Bronchoscopic biopsy of the tumor and subsequent left pneumonectomy with concurrent lymph node dissection revealed an atypical carcinoid. Sixteen months after surgery the patient has been asymptomatic with repeat imaging studies showing no change in mediastinal shifting. CONCLUSION: Bronchial carcinoids are notorious for causing bronchial obstruction. The present case represents an extreme complication of centrally located bronchial carcinoid, resulting in postpneumonectomy-like syndrome with severe mediastinal shift and herniation of the healthy lung into the diseased hemithorax.


Assuntos
Obstrução das Vias Respiratórias/etiologia , Neoplasias Brônquicas/complicações , Tumor Carcinoide/complicações , Hérnia/etiologia , Pneumopatias/etiologia , Adulto , Obstrução das Vias Respiratórias/diagnóstico por imagem , Obstrução das Vias Respiratórias/cirurgia , Neoplasias Brônquicas/diagnóstico por imagem , Neoplasias Brônquicas/cirurgia , Tumor Carcinoide/diagnóstico por imagem , Tumor Carcinoide/cirurgia , Feminino , Hérnia/diagnóstico por imagem , Humanos , Pneumopatias/diagnóstico por imagem , Pneumonectomia , Complicações Pós-Operatórias , Síndrome
16.
Asian Cardiovasc Thorac Ann ; 27(3): 228-230, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30674209

RESUMO

Endobronchial metastasis from extrapulmonary solid tumors is rare, and endobronchial metastasis from the prostate is even more unusual. An 80-year-old patient presented with significant dyspnea secondary to metastatic stromal cell sarcoma of the prostate, which occluded the right main bronchus. The tumor, causing complete collapse of the right lung, was found on computed tomography and confirmed by bronchoscopy. We successfully excised the lesion using cryotherapy, with immediate resolution of symptoms and radiological lung reexpansion.


Assuntos
Obstrução das Vias Respiratórias/etiologia , Neoplasias Brônquicas/complicações , Neoplasias Brônquicas/secundário , Neoplasias da Próstata/patologia , Sarcoma/complicações , Sarcoma/secundário , Idoso de 80 Anos ou mais , Neoplasias Brônquicas/diagnóstico por imagem , Neoplasias Brônquicas/cirurgia , Broncoscopia , Criocirurgia , Dispneia/etiologia , Humanos , Masculino , Sarcoma/diagnóstico por imagem , Sarcoma/cirurgia , Tomografia Computadorizada por Raios X , Resultado do Tratamento
17.
Ann Thorac Surg ; 108(2): e119-e120, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30682355

RESUMO

Extramedullary plasmacytomas are rare tumors that typically involve the head and neck region. Only three reports exist in the literature of extramedullary plasmacytomas that involve the lower airways. We report the case of a 54-year-old woman with EMP of the right mainstem bronchus treated with sleeve resection.


Assuntos
Brônquios/diagnóstico por imagem , Neoplasias Brônquicas/diagnóstico , Broncoscopia/métodos , Plasmocitoma/diagnóstico , Biópsia , Brônquios/cirurgia , Neoplasias Brônquicas/cirurgia , Diagnóstico Diferencial , Feminino , Humanos , Pessoa de Meia-Idade , Plasmocitoma/cirurgia , Tomografia Computadorizada por Raios X
18.
Ann Thorac Surg ; 107(3): e203-e205, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30205116

RESUMO

Cellular schwannoma is a rare variant of schwannoma, showing high cellularity and a low mitotic index. A 64-year-old man was admitted to our hospital with a 2-month history of productive cough. Chest computed tomography showed an endobronchial tumor with complete atelectasis of the right lower lobe. Bronchoscopy showed an endobronchial tumor occluding the intermediate bronchus that was diagnosed as a cellular schwannoma on biopsy and was successfully excised with a right lower sleeve lobectomy to preserve the middle lobe. The postoperative course was uneventful, and the patient remains well with no sign of recurrence at the 7-year follow-up.


Assuntos
Neoplasias Brônquicas/cirurgia , Neurilemoma/cirurgia , Pneumonectomia/métodos , Biópsia , Brônquios/diagnóstico por imagem , Neoplasias Brônquicas/diagnóstico , Broncoscopia , Humanos , Masculino , Pessoa de Meia-Idade , Neurilemoma/diagnóstico , Tomografia Computadorizada por Raios X
19.
J Pediatr Hematol Oncol ; 41(1): 67-70, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-29432305

RESUMO

Bronchial carcinoid tumor, while rare, remains the most common primary malignant lung tumor in children. We present a retrospective analysis of 7 patients with typical bronchial carcinoid tumors diagnosed at 2 pediatric tertiary care referral centers between 1990 and 2014. The most common presenting symptom was pneumonia, followed by respiratory distress. Somatostatin scans were performed in selected patients. All patients had negative resection margin following surgery and were alive without disease at last follow-up. Typical carcinoid tumors have a good prognosis following definitive surgical resection. A review of published literature on pediatric bronchial carcinoid tumors is provided.


Assuntos
Neoplasias Brônquicas/cirurgia , Tumor Carcinoide/cirurgia , Adolescente , Neoplasias Brônquicas/metabolismo , Neoplasias Brônquicas/patologia , Tumor Carcinoide/metabolismo , Tumor Carcinoide/patologia , Criança , Feminino , Seguimentos , Humanos , Masculino , Estudos Retrospectivos
20.
Am J Med Sci ; 357(1): 75-80, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30314832

RESUMO

Ewing sarcoma/peripheral primitive neuroectodermal tumors (ES/pPNET), a member of the Ewing sarcoma family of tumors, is a malignant soft tissue tumor with small undifferentiated neuroectodermal cells. Primary trachea-bronchial ES/pPNET is very rare. The most common pulmonary ES is due to a metastasis. We describe a case of ES/pPNET which originated in the left basal trunk bronchus. The patient was a 30-year-old male, presenting with irritable cough and fever for 10 days. A tumor of 60 mm in diameter was found in the left basal trunk bronchus, extending to the left lower lobe. No distant metastases were detected. Histopathological examination revealed a malignancy of ES/pPNET with a diffuse proliferation of round cells, a Flexner-Wintersteiner rosette formation and positive staining for CD99. The patient was successfully treated with a combination of left lower lobectomy and adjuvant chemotherapy and has remained disease-free for approximately 18 months at follow-up. This case highlights that ES/pPNET should be considered as a differential diagnosis in cases of trachea-bronchial tumors.


Assuntos
Brônquios/patologia , Neoplasias Brônquicas/diagnóstico , Tumores Neuroectodérmicos Primitivos Periféricos/diagnóstico , Sarcoma de Ewing/diagnóstico , Adulto , Neoplasias Brônquicas/diagnóstico por imagem , Neoplasias Brônquicas/tratamento farmacológico , Neoplasias Brônquicas/cirurgia , Humanos , Masculino , Tumores Neuroectodérmicos Primitivos Periféricos/diagnóstico por imagem , Tumores Neuroectodérmicos Primitivos Periféricos/tratamento farmacológico , Tumores Neuroectodérmicos Primitivos Periféricos/cirurgia , Sarcoma de Ewing/diagnóstico por imagem , Sarcoma de Ewing/tratamento farmacológico , Sarcoma de Ewing/cirurgia
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