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1.
Adv Exp Med Biol ; 1226: 51-56, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32030675

RESUMO

Cardiac tumors are found in less than 1% of adult and pediatric autopsies. More than three-fourths of primary cardiac neoplasms are benign, with myxomas and rhabdomyomas being the most common cardiac tumors seen in adults and children, respectively. Primary malignant cardiac tumors are extremely rare, whereas metastatic lesions can be seen in approximately 8% of patients dying from cancer. Attempting to understand why the heart is so resistant to carcinogenesis and which fail-safe mechanisms malfunction when cardiac tumors do develop is particularly challenging considering the rarity of these tumors and the fact that when relevant clinical studies are published, they rarely focus on molecular pathogenesis. Apart from cancer cells, solid tumors are comprised of a concoction of noncancerous cells, and extracellular matrix constituents, which along with pH and oxygen levels jointly constitute the so-called tumor microenvironment (TME). In the present chapter, we explore mechanisms through which TME may influence cardiac carcinogenesis.


Assuntos
Carcinogênese , Neoplasias Cardíacas/patologia , Microambiente Tumoral , Humanos , Mixoma/patologia , Rabdomioma/patologia
2.
Medicine (Baltimore) ; 99(3): e18813, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32011489

RESUMO

INTRODUCTION: Pulmonary artery intimal sarcoma (PAIS) is a rare and highly aggressive tumor, and approximately 80% of pulmonary cases occur in the pulmonary trunk. We report herein a case of retrograde extension of the sarcoma to the pulmonary valve and right ventricle, which is an uncommon manifestation of this lethal tumor. PATIENT CONCERNS: A 41-year-old woman was initially diagnosed with pulmonary thromboembolism (PTE) and transferred to our hospital. DIAGNOSIS: Computed tomographic pulmonary angiography (CTPA) showed that there are low-density filling defects in both pulmonary arteries, and the patient was diagnosed with PTE. However, the ultrasonographers considered that the lesion is a space-occupying type that involves the right ventricular outflow tract and pulmonary valve instead of PTE. Postoperative pathology confirmed the diagnosis of PAIS. INTERVENTIONS: The patient underwent resection of pulmonary artery sarcoma and endarterectomy. OUTCOMES: During the follow-up via telephone 1 month after discharge, the patient reported to have been feeling well. CONCLUSION: Owing to the rarity of the disease and its non-specific clinical manifestations, approximately half of the PAIS cases are misdiagnosed or have a delayed diagnosis. Thus, improving our understanding of the disease and facilitating its early diagnosis are essential.


Assuntos
Neoplasias Cardíacas/diagnóstico , Artéria Pulmonar , Sarcoma/diagnóstico , Neoplasias Vasculares/diagnóstico , Adulto , Erros de Diagnóstico , Feminino , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/cirurgia , Doenças das Valvas Cardíacas/diagnóstico , Doenças das Valvas Cardíacas/patologia , Doenças das Valvas Cardíacas/cirurgia , Humanos , Embolia Pulmonar/diagnóstico , Valva Pulmonar , Sarcoma/patologia , Sarcoma/cirurgia , Neoplasias Vasculares/patologia , Neoplasias Vasculares/cirurgia
3.
Medicine (Baltimore) ; 98(49): e18193, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31804339

RESUMO

RATIONALE: Primary cardiac angiosarcoma is a rare malignant cardiac neoplasm with early metastasis and poor prognosis. As there are currently no guidelines or effective therapeutic strategies, management of this condition depends on previous experiences of the clinician treating and the consideration of reported cases. PATIENT CONCERNS: A 65-year-old male presented to our department with a 4-day history of chest tightness, dyspnea, lower extremity weakness and occasional dizziness, and a transthoracic echo (TTE) revealed a right atrium occupying mass. DIAGNOSES: TTE showed right atrium occupation, and the post-operative histopathology showed the tumor to be a primary cardiac angiosarcoma. INTERVENTIONS: Right atrium tumor resection and right atrium reconstruction with a bovine pericardium were performed. OUTCOMES: The patient recovered from surgery and discharged but died 10 months after surgery because of complete resection was impossible and adjuvant therapy was not performed. LESSONS: Resection of primary cardiac angiosarcomas should be integrated with a combination of chemotherapy, radiotherapy, and targeted therapy based on tumor cell gene mutation and altered expression.


Assuntos
Neoplasias Cardíacas/patologia , Hemangiossarcoma/patologia , Idoso , Ecocardiografia , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/patologia , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/cirurgia , Hemangiossarcoma/diagnóstico por imagem , Hemangiossarcoma/cirurgia , Humanos , Masculino
4.
Medicine (Baltimore) ; 98(49): e18281, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31804369

RESUMO

RATIONALE: Cardiac papillary fibroelastoma is a small, benign endocardial tumor, while it is clinically important because of its strategic position and propensity for causing embolic events and hemodynamic complications. PATIENT CONCERNS: A 59-year-old female presented our hospital for investigation and treatment of a sudden onset of syncope lasted about 2 minutes. DIAGNOSES: Cardiac papillary fibroelastoma arising from left inferior pulmonary vein in left atrium. INTERVENTIONS: The tumor was successfully removed by cardiac surgery. OUTCOMES: The patient's postoperative course was uneventful, and she was discharged 10 days after surgery. The patient remained free of neurologic deficits and had no evidence of residual or recurrence of tumor with echocardiography during 1 year of follow-up. LESSONS: Cardiac papillary fibroelastoma is a benign tumor, with increased risk of thromboembolic events. It is often diagnosed in patients with echocardiography by chance or after a neurologic event. Complete surgical resection should be considered when the patient is indicated and the long-term postoperative prognosis is excellent.


Assuntos
Fibroma/cirurgia , Átrios do Coração/cirurgia , Neoplasias Cardíacas/cirurgia , Veias Pulmonares/cirurgia , Diagnóstico Diferencial , Feminino , Fibroma/patologia , Átrios do Coração/patologia , Neoplasias Cardíacas/patologia , Humanos , Pessoa de Meia-Idade , Músculos Papilares , Veias Pulmonares/patologia
5.
Medicine (Baltimore) ; 98(51): e18386, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31861001

RESUMO

RATIONALE: Pulmonary embolisms (PEs) are caused by emboli, which mostly originate from deep venous thrombi that travel to and suddenly block the pulmonary arteries. The emboli are usually thrombi, and right atrial myxoma emboli are rare. PATIENT CONCERNS: A 55-year-old man presented with shortness of breath and syncope. We proceeded with computed tomography pulmonary angiography (CTPA) and transthoracic echocardiogram (TTE), the results of which suggested that the diagnosis was a right atrial mass. DIAGNOSIS: A definitive diagnosis compatible with a right atrial myxoma (RAM) with tumoral pulmonary emboli after surgical excision was made. INTERVENTION: Right atrial and pulmonary artery embolectomy. OUTCOMES: The patient followed an uneventful course during the 6 years of follow-up after surgery. According to a review of the literature, RAMs are often not diagnosed in a timely manner or even go completely undiagnosed. TTE, transesophageal echocardiography (TEE), CT, magnetic resonance imaging (MRI), and positron emission tomography/computed tomography may be helpful in the preoperative diagnosis. Surgical removal of the masses from the atrium and pulmonary arteries was relatively uneventful. LESSONS: RAMs should be considered unlikely reasons for fatal pulmonary embolisms.


Assuntos
Átrios do Coração/diagnóstico por imagem , Neoplasias Cardíacas/diagnóstico por imagem , Mixoma/diagnóstico por imagem , Embolia Pulmonar/etiologia , Angiografia por Tomografia Computadorizada , Ecocardiografia , Átrios do Coração/cirurgia , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Mixoma/patologia , Mixoma/cirurgia , Embolia Pulmonar/cirurgia
6.
Heart Surg Forum ; 22(5): E317-E318, 2019 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-31596704

RESUMO

Cardiac myxoma typically is thought to be a slow-growing, benign primary. Atrial myxomas can lead to many complications and can also mimic mitral stenosis, infective endocarditis, and other vascular diseases associated with systemic embolization. A 75-year-old woman with a history of lung cancer (pT1cN1, adenocarcinoma), atrial fibrillation, and a cerebral infarction presented with dysarthria and visual disturbances. In our case, we had to consider some questionable issues with the left atrial mass, and whether the recurrence of cerebral events was due to the thrombotic material in the left atrium or from locally recurrent lung cancer from the stump margin of the previously resected left superior pulmonary vein. We present a case with a rapidly-growing left atrial myxoma with a growth rate of 12.60 mm/month, rather than a thrombus or local recurrence of tumor under a medication of non-VKA oral antagonists.


Assuntos
Adenocarcinoma/diagnóstico , Neoplasias Cardíacas/diagnóstico , Neoplasias Pulmonares/diagnóstico , Mixoma/diagnóstico , Recidiva Local de Neoplasia/diagnóstico , Adenocarcinoma/cirurgia , Idoso , Fibrilação Atrial/etiologia , Infarto Cerebral/diagnóstico , Infarto Cerebral/etiologia , Diagnóstico Diferencial , Progressão da Doença , Endocardite/diagnóstico , Feminino , Átrios do Coração , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/cirurgia , Humanos , Neoplasias Pulmonares/cirurgia , Estenose da Valva Mitral/diagnóstico , Mixoma/patologia , Mixoma/cirurgia
7.
BMC Neurol ; 19(1): 249, 2019 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-31646971

RESUMO

BACKGROUND: Cardiac myxoma is the most common benign cardiac tumor. Brain metastases or multiple cerebral aneurysms are extremely rare, especially for the case of both complications. Brain metastases are usually found at the same time or few months after the diagnosis or surgical removal of cardiac myxoma CASE PRESENTATION: We describe a case of patient, operated for a cardiac myxoma, who presented multiple central nervous system metastases associated, cerebral aneurysms and subsequent intracerebral hemorrhage CONCLUSIONS: The long-term follow-up of the patients with atrial myxoma even after complete surgical excision is recommended, especially for the patient with central nervous system manifestations before atrial myxoma excision.


Assuntos
Neoplasias Encefálicas/secundário , Neoplasias Cardíacas/patologia , Aneurisma Intracraniano/etiologia , Mixoma/patologia , Adulto , Hemorragia Cerebral/etiologia , Feminino , Átrios do Coração/patologia , Humanos
8.
Medicine (Baltimore) ; 98(38): e17250, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31567993

RESUMO

RATIONALE: Central retinal artery occlusion (CRAO) due to cardiac myxoma primarily occurs in elderly individuals. Early detection and surgical resection of myxoma are extremely important because CRAO causes complete blindness in most cases. However, due to the extremely low incidence of CRAO caused by cardiac myxoma in the pediatric age group, such condition is rarely reported. PATIENT CONCERNS: A 16-year-old female patient visited our hospital due to sudden onset of vision loss in the left eye, dysarthria, and right-sided hemiplegia. DIAGNOSES: She was diagnosed with CRAO via fundoscopy. Results showed a cherry-red spot, indicating CRAO. Brain magnetic resonance imaging (MRI) revealed multifocal diffusion-restricted foci, particularly in the left frontal lobe. Echocardiography revealed a left atrial mass measuring 4.21 cm × 2.25 cm. The mass was attached to the interseptum and moved along the inflow of the mitral valve. Cardiac computed tomography (CT) revealed an enhanced mass measuring 3 cm × 2.2 cm × 3 cm and with irregular margin on the anterior wall of the left atrium and the border of the fossa ovalis. INTERVENTIONS: The patient underwent surgical excision under general anesthesia. Intraoperative finding showed a huge, jelly-like, and extremely friable mass. Pathological examination confirmed myxoma. OUTCOMES: During a follow-up of 2 years after diagnosis, she did not present with other neurological deficits and no residual mass was observed on echocardiography. However, visual impairment of the left eye persisted. LESSONS: Most patients with CRAO may present with other mild symptoms that are often be neglected before CRAO development. We recommend that patients who present with frequent syncopal attack or symptoms of transient ischemic attack should undergo echocardiography.


Assuntos
Cegueira/etiologia , Átrios do Coração , Neoplasias Cardíacas/complicações , Mixoma/complicações , Adolescente , Ecocardiografia , Feminino , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/patologia , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/patologia , Humanos , Mixoma/diagnóstico por imagem , Mixoma/patologia , Oclusão da Artéria Retiniana/complicações , Oclusão da Artéria Retiniana/diagnóstico , Oclusão da Artéria Retiniana/etiologia , Tomografia Computadorizada por Raios X
9.
Ann Clin Lab Sci ; 49(4): 468-473, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31471335

RESUMO

OBJECTIVE: To explore the clonal origin pattern of cardiac myxoma and its relationship with recurrence of the disease. METHODS: 20 female patients diagnosed with cardiac myxoma underwent appropriate surgery and were followed-up after the treatment. The DNA of tumor tissues and pairing normal tissues from 20 patients were taken, with polymerase chain reaction (PCR) assay being used to amplify the HUMARA gene on X-chromosome, which could hint the tumor cloning state. Cases were divided into a polyclonal origin group and monoclonal origin group, according to the PCR result. The recurrence rate in the two groups was compared using Fisher's exact probability method. RESULTS: All tumors were successfully removed. PCR assay showed that the hybrid rate in tumors was 90.0% (18/20). Among them, 88.9%(16/18) of cases were identified as polyclonal origin and 11.1%(2/18) were identified as monoclonal origin. After 4 years of follow-up, the recurrence rate was 12.5(2/16) in the polyclonal origin group and 0%(0/2) in monoclonal origin group, with significant difference between the two groups (P<0.05). CONCLUSION: Cardiac myxoma is mostly of polyclonal original, and its polyclonal origin characteristics may contribute to tumor recurrence.


Assuntos
Células Clonais/patologia , Neoplasias Cardíacas/patologia , Mixoma/patologia , Recidiva Local de Neoplasia/patologia , Feminino , Neoplasias Cardíacas/genética , Heterozigoto , Humanos , Mixoma/genética , Receptores Androgênicos/genética
11.
Braz J Cardiovasc Surg ; 34(4): 499-502, 2019 08 27.
Artigo em Inglês | MEDLINE | ID: mdl-31454208

RESUMO

Cardiac papillary fibroelastoma are rare, benign cardiac tumors that may lead to lethal complications from embolization or valvular dysfunction if left untreated. When working up symptomatic tumors with concomitant angina, traditional diagnostic studies such as cardiac catheterization may predispose the patient to embolic complications if the mass is located in the path of the catheter. Newer, non-invasive diagnostic testing, such as cardiac magnetic resonance imaging or dynamic computed tomography angiography, may be considered in lieu of invasive approaches to avoid potentially devastating complications. We herein present a case report of a 77-year-old female with a symptomatic aortic valve tumor and describe our diagnostic strategy and management.


Assuntos
Valva Aórtica/diagnóstico por imagem , Neoplasias Cardíacas/diagnóstico por imagem , Idoso , Angiografia por Tomografia Computadorizada/métodos , Feminino , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/cirurgia , Doenças das Valvas Cardíacas/diagnóstico por imagem , Doenças das Valvas Cardíacas/cirurgia , Humanos
14.
Braz J Cardiovasc Surg ; 34(3): 372-376, 2019 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-31310479

RESUMO

We are going to present a case of malignant fibrous histiocytoma in the right atrium, which is a very rare entity. The patient had a right atrial mass, which prolapsed through the tricuspid valve into the right ventricle, causing functional tricuspid valve stenosis. The tumor was completely resected and the patient had an uneventful postoperative period. Histopathological examination reported malignant fibrous histiocytoma. The patient presented to the emergency department five weeks after discharge with dyspnea and palpitation. Echocardiography and magnetic resonance imaging revealed recurrent right atrial tumor mass. His clinical status has worsened, with syncope and acute renal failure. On the repeated echocardiography, suspected tumor recurrence was observed in left atrium, which probably caused systemic embolization. Considering the aggressive nature of the tumor and systemic involvement, our Heart Council decided to provide palliative treatment by nonsurgical management. His status deteriorated for the next few days and the patient succumbed to a cardiac arrest on the 4th day.


Assuntos
Neoplasias Cardíacas/patologia , Histiocitoma Fibroso Maligno/patologia , Angiografia Coronária , Ecocardiografia , Evolução Fatal , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/patologia , Neoplasias Cardíacas/diagnóstico por imagem , Histiocitoma Fibroso Maligno/diagnóstico por imagem , Humanos , Imagem por Ressonância Magnética , Masculino , Recidiva Local de Neoplasia , Doenças Raras , Tomografia Computadorizada por Raios X , Prolapso da Valva Tricúspide/diagnóstico por imagem , Prolapso da Valva Tricúspide/patologia
15.
BMJ Case Rep ; 12(7)2019 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-31289165

RESUMO

Cowden syndrome (CS) is a rare disorder characterised by multiple non-cancerous, tumour-like growths called hamartomas. The syndrome is associated with the development of cancer of the breast, endometrium, kidneys, skin and rarely the brain. We report a rare case of symptomatic cardiac haemangioma in a patient with CS. A 54-year-old woman with CS presented with dyspnoea and orthopnoea in the setting of cardiac tamponade. Echocardiography revealed a large haemopericardium and tamponade physiology, secondary to a pericardial mass. The patient underwent urgent cardiopulmonary bypass with removal of the mass. Histopathology confirmed a benign cavernous haemangioma. We postulate that tumours involving the heart/pericardium may be an additional manifestation of CS. This case further highlights the necessity to consider pericardial/cardiac manifestations in patients with hamartomatous syndromes who present with cardiorespiratory symptoms, so that opportunistic investigation and treatment may be instituted.


Assuntos
Tamponamento Cardíaco/etiologia , Síndrome do Hamartoma Múltiplo/complicações , Hemangioma Cavernoso/complicações , Hemangioma Cavernoso/cirurgia , Tamponamento Cardíaco/diagnóstico por imagem , Ponte Cardiopulmonar/métodos , Ecocardiografia/métodos , Feminino , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/patologia , Neoplasias Cardíacas/patologia , Hemangioma Cavernoso/diagnóstico por imagem , Hemangioma Cavernoso/patologia , Humanos , Pessoa de Meia-Idade , Resultado do Tratamento
16.
Clin Nucl Med ; 44(11): 892-894, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31274563

RESUMO

Hamartoma of mature cardiac myocytes is an extremely rare type of benign cardiac tumor with a slow growth rate and generally occurs in adults. We report a case with hamartoma of mature cardiac myocytes of the right auricle demonstrating intense F-FDG uptake and a large amount of pericardial effusion on PET/CT mimicking malignancy in a 41-year-old man. Hamartoma of mature cardiac myocytes should be considered among the differential diagnoses when an F-FDG-avid primary focal cardiac mass is found in patients with malignant features on PET/CT imaging.


Assuntos
Fluordesoxiglucose F18 , Hamartoma/diagnóstico por imagem , Hamartoma/patologia , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/patologia , Miócitos Cardíacos/patologia , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Adulto , Diagnóstico Diferencial , Humanos , Masculino
17.
BMC Cancer ; 19(1): 529, 2019 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-31151427

RESUMO

BACKGROUND: Undifferentiated pleomorphic sarcoma is a very rare and aggressive type of primary cardiac tumors. Most cardiac sarcomas result in rapid growth and quick death. According to different sources the median survival is typically 6 to 12 months. We are presenting a case of primary cardiac sarcoma with 26 months disease free survival following cytoreductive surgery and chemotherapy. CASE PRESENTATION: A 48-year-old woman with progressing symptoms of dyspnea and palpitations for over 2 months was referred to a cardiologist. With the help of echocardiography and cardiovascular magnetic resonance cardiac sarcoma was suspected. Open biopsy and cytoreductive surgery were performed, complete resection of the tumor was not possible. Histology revealed undifferentiated pleomorphic sarcoma. Seven cycles of chemotherapy with Doxorubicine and Ifosfamide were completed. Cardiovascular magnetic resonance revealed a complete response - only signs of fibrosis without any signs of tumor were visible. Follow ups with echocardiography, cardiovascular magnetic resonance and chest, abdomen and pelvic computed tomography is performed every 3 months. Twenty-six months from initial diagnosis the patient is still free of recurrence of tumor with no compromises of the quality of life. CONCLUSION: Standard chemotherapy together with cytoreductive surgery can have a complete response effect in undifferentiated pleomorphic sarcoma with unusual long-term survival.


Assuntos
Neoplasias Cardíacas/terapia , Histiocitoma Fibroso Maligno/terapia , Biópsia , Quimioterapia Adjuvante , Terapia Combinada , Procedimentos Cirúrgicos de Citorredução , Doxorrubicina/administração & dosagem , Feminino , Seguimentos , Neoplasias Cardíacas/diagnóstico , Neoplasias Cardíacas/patologia , Histiocitoma Fibroso Maligno/diagnóstico , Histiocitoma Fibroso Maligno/patologia , Humanos , Ifosfamida/administração & dosagem , Pessoa de Meia-Idade , Qualidade de Vida , Resultado do Tratamento
18.
Pediatr Hematol Oncol ; 36(4): 244-251, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31179809

RESUMO

In the era of neoadjuvant and adjuvant chemotherapy, extrapulmonary involvement by high-grade osteosarcoma (HGOS) is rare. Importantly however, HGOS metastasis in the form of cardiovascular tumor thrombus portends a dismal prognosis. Thus, prompt and accurate identification of tumor thrombus is crucial. We report here two unique cases of recurrent HGOS, presenting as thrombotic events, in order to increase awareness and index of suspicion among practitioners regarding this presentation. Additionally, we review 14 previously reported pediatric cases of cardiovascular metastatic HGOS.


Assuntos
Neoplasias Ósseas , Osteossarcoma , Embolia Pulmonar , Trombose , Adolescente , Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Ósseas/patologia , Feminino , Átrios do Coração/diagnóstico por imagem , Átrios do Coração/patologia , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/secundário , Humanos , Metástase Neoplásica , Osteossarcoma/diagnóstico por imagem , Osteossarcoma/tratamento farmacológico , Osteossarcoma/patologia , Embolia Pulmonar/diagnóstico por imagem , Embolia Pulmonar/patologia , Trombose/diagnóstico por imagem , Trombose/patologia
20.
Int J Cardiovasc Imaging ; 35(9): 1615-1618, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31041634

RESUMO

Malignant peripheral nerve sheath tumors are rare sarcomas of children and adolescents, and they are aggressive tumors with a high rate of local recurrence. Here we report a case of a primary cardiac malignant peripheral nerve sheath tumor without neurofibromatosis type I. A 53-year old woman presented having had cough, expectoration, and dyspnea for 20 days and was found to have a heart-involving tumor diagnosed as a malignant peripheral nerve sheath tumor, a rare cardiac sarcoma of 9 × 4.5 × 3 cm in size. The patient underwent a successful resection of the tumor but died 14 months postoperative. We report this case for its rarity and peculiar mode of morphologic and immunohistochemical presentation.


Assuntos
Neoplasias Cardíacas , Neurofibrossarcoma , Biomarcadores Tumorais/análise , Biópsia , Procedimentos Cirúrgicos Cardíacos , Ecocardiografia , Evolução Fatal , Feminino , Neoplasias Cardíacas/química , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/cirurgia , Humanos , Imuno-Histoquímica , Pessoa de Meia-Idade , Neurofibrossarcoma/química , Neurofibrossarcoma/diagnóstico por imagem , Neurofibrossarcoma/patologia , Neurofibrossarcoma/cirurgia , Fatores de Tempo , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Carga Tumoral
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