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1.
Virchows Arch ; 476(1): 159-174, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31838586

RESUMO

According to the WHO, mesenchymal tumours of the maxillofacial bones are subdivided in benign and malignant maxillofacial bone and cartilage tumours, fibro-osseous and osteochondromatous lesions as well as giant cell lesions and bone cysts. The histology always needs to be evaluated considering also the clinical and radiological context which remains an important cornerstone in the classification of these lesions. Nevertheless, the diagnosis of maxillofacial bone tumours is often challenging for radiologists as well as pathologists, while an accurate diagnosis is essential for adequate clinical decision-making. The integration of new molecular markers in a multidisciplinary diagnostic approach may not only increase the diagnostic accuracy but potentially also identify new druggable targets for precision medicine. The current review provides an overview of the clinicopathological and molecular findings in maxillofacial bone tumours and discusses the diagnostic value of these genetic aberrations.


Assuntos
Ossos Faciais/patologia , Neoplasias Maxilares/patologia , Neoplasias Cranianas/patologia , Condrossarcoma/genética , Condrossarcoma/patologia , Displasia Fibrosa Óssea/genética , Displasia Fibrosa Óssea/patologia , Granuloma de Células Gigantes/patologia , Humanos , Neoplasias Maxilares/diagnóstico , Neoplasias Maxilares/genética , Neoplasias Cranianas/diagnóstico , Neoplasias Cranianas/genética
2.
World Neurosurg ; 134: e559-e565, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31678450

RESUMO

BACKGROUND: Prostate carcinomas rarely metastasize to the central nervous system but, when they do, dural localizations are as common as and far more aggressive than intraparenchymal ones. Those metastases can be further classified according to their extension toward the subdural or extradural space and can frequently simulate other pathologic conditions including chronic subdural hematomas, abscess, and primary bone tumors. Beside the challenges of the preoperative differential diagnostic and complexity of surgical planning and operative excision, subdural metastases seem to carry a much poorer prognosis. METHODS: A series of consecutive patients admitted during a 12-year period through our oncall pathway for subdural/extradural collections or intraparenchymal lesions found, on histologic analysis, to represent intracranial prostate cancer metastases was retrospectively reviewed. RESULTS: A total of 19 patients were included, but only 3 were diagnosed with small cell prostate carcinoma, while the majority had a primary prostate adenocarcinoma. Metastases could be classified as pure subdural space lesions, dural-based lesions, extradural/bony lesions, and pure intraparenchymal lesions. All patients with subdural metastases and 3 out of 5 patients with dural-based lesions required an emergency intervention due to rapidly deteriorating neurologic status. The mean follow-up in our series was 37 months; only subdural localizations had a remarkably unfavorable outcome. CONCLUSIONS: Supported by our experience and the review of the literature, we suggest that a low threshold for contrast-enhanced computed tomography/magnetic resonance imaging is advisable in case of suspicious subdural collection, even in an emergency setting, for patients with previous medical history of prostate cancer.


Assuntos
Neoplasias Encefálicas/secundário , Carcinoma/patologia , Neoplasias Meníngeas/secundário , Neoplasias da Próstata/patologia , Idoso , Neoplasias Encefálicas/classificação , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/terapia , Carcinoma/classificação , Carcinoma/diagnóstico , Carcinoma/terapia , Gerenciamento Clínico , Humanos , Masculino , Neoplasias Meníngeas/classificação , Neoplasias Meníngeas/diagnóstico , Neoplasias Meníngeas/terapia , Pessoa de Meia-Idade , Prognóstico , Estudos Prospectivos , Neoplasias da Próstata/classificação , Neoplasias da Próstata/diagnóstico , Neoplasias da Próstata/terapia , Estudos Retrospectivos , Neoplasias Cranianas/classificação , Neoplasias Cranianas/diagnóstico , Neoplasias Cranianas/secundário , Neoplasias Cranianas/terapia
4.
PLoS One ; 14(8): e0220922, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31408483

RESUMO

The advent of new technologies in medical imaging and 3D printing in recent years has made customization of surgical tools and implants more accessible, revolutionizing many surgical fields. In many human diseases, these implants have led to superior surgical outcomes and greatly improved patients' quality of life. Thus, it is of great interest to apply these technologies to the treatment of animal diseases. In this study, we report the use of computed tomography (CT) and 3D printing for the treatment of a Great Hornbill at Jurong Bird Park that was diagnosed with squamous cell carcinoma of the casque. A 3D printed prosthesis that perfectly fitted the subject was implanted to replace its resected casque. The subject exhibited natural eating behaviour with no post-operative complications. Using this case as an example, the positive outcomes suggest a great potential in applying these technologies to the treatment of other wildlife diseases.


Assuntos
Doenças das Aves , Aves , Carcinoma de Células Escamosas , Impressão Tridimensional , Próteses e Implantes , Neoplasias Cranianas , Tomografia Computadorizada por Raios X , Animais , Doenças das Aves/diagnóstico por imagem , Doenças das Aves/cirurgia , Carcinoma de Células Escamosas/diagnóstico por imagem , Carcinoma de Células Escamosas/cirurgia , Carcinoma de Células Escamosas/veterinária , Desenho de Prótese , Implantação de Prótese , Neoplasias Cranianas/diagnóstico , Neoplasias Cranianas/cirurgia , Neoplasias Cranianas/veterinária
5.
Acta Otolaryngol ; 139(10): 837-842, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31373256

RESUMO

Background: Temporal bone chondrosarcoma (TBC) are uncommon primary temporal bone malignancies, and clinicians lack experience in its diagnosis and treatment. The optimal management of patients with tumor of TBC also remains a topic of debate and controversy. Objectives: This article summarizes the experience of diagnosis and treatment of TBC, in order to improve the quality of life of cancer patients in the future. Material and methods: We conducted a retrospective analysis of 10 patients who were referred to our hospital from June 2009 to June 2018 for the treatment of TBC. Results: There were 3 males and 7 females. The most common presenting symptoms were facial paresis (50%) and hearing loss (40%), whereas otalgia (10%), vertigo (10%) and headache (10%) were less common. All tumors originated from the temporal bone, and 80% involved the jugular foramen area. All patients survived without evidence of disease at a median time of follow up of 28.8 months. Conclusions and significance: TBC mostly originated in the middle ear mastoid area, and easily extended to the jugular foramen area. An individualized surgical procedure that removes tumors integrally with minimal nerve and blood vessel damage provides long-term cancer control and minimal morbidity in most cases.


Assuntos
Condrossarcoma/diagnóstico , Condrossarcoma/terapia , Neoplasias Cranianas/diagnóstico , Neoplasias Cranianas/terapia , Osso Temporal , Adulto , Idoso , Terapia Combinada , Feminino , Humanos , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Qualidade de Vida , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Resultado do Tratamento
6.
World Neurosurg ; 130: 187-191, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31299307

RESUMO

BACKGROUND: Cranioplasty is a common procedure in neurosurgery. However, cosmetic and neuroprotective reconstructions are necessary after cranioplasty. Treatment of patients with a meningioma with bone infiltration requires removal of the tumor-infiltrated bone and subsequent cranioplasty. We report an efficient technique for cosmetic and neuroprotective reconstructions using a custom-made ultra-high-molecular-weight polyethylene cranial plate (SKULPIO, Kyocera Medical, Kyoto, Japan) in a single-step surgery involving tumor removal and skull reconstruction. METHODS: We present 2 illustrative cases of a 49-year-old female with a right frontal convexity meningioma and 69-year-old male with a bilateral parasagittal atypical meningioma, both involving extensive skull invasion. We preoperatively planned craniotomy size to facilitate the removal of the tumor-infiltrated skull bone using the patients' 3-dimensional cranial models followed by the construction of a custom-made cranial plate. After tumor removal, we drilled out the outer table and the diploe of the cranial edge until the custom-made bone plate accurately fit the bone defect. Finally, the cranial plate was fixed using titanium plates and screws. RESULTS: Postoperative magnetic resonance imaging for each case revealed total meningioma removal and an aesthetically reconstructed skull. Using this technique, precise adjustment of the cranial edge to the plate contributes to a gapless and aesthetic reconstruction. Furthermore, the intact inner table of the skull firmly supports the custom-made bone plate. CONCLUSIONS: This technique involving the placement of a custom-made cranial plate during a single-step surgery was found to be efficient for cosmetic and neuroprotective reconstructions.


Assuntos
Neoplasias Meníngeas/cirurgia , Meningioma/cirurgia , Polietilenos , Neoplasias Cranianas/cirurgia , Crânio/cirurgia , Idoso , Placas Ósseas , Feminino , Humanos , Masculino , Neoplasias Meníngeas/diagnóstico , Meningioma/diagnóstico , Pessoa de Meia-Idade , Procedimentos Neurocirúrgicos/métodos , Procedimentos Cirúrgicos Reconstrutivos/métodos , Neoplasias Cranianas/diagnóstico
7.
BMC Neurol ; 19(1): 176, 2019 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-31337352

RESUMO

BACKGROUND: Primary intraosseous meningioma is a subset of extradural meningioma that arises in the bone, and only a few cases have been reported to date. CASE PRESENTATION: An 80-year-old man presented with decreased hearing on the right side accompanied by a disturbance of balance 10 months prior to admission. Magnetic resonance imaging revealed an 8 × 7 cm osteolytic mass in the right posterior fossa related to the petrous bone, with extension to the cervical region. During surgery, the tumor was found to be located extradurally, with no invasion of the dura. The tumor was removed entirely, apart from a small portion around the jugular foramen to avoid lower cranial nerve injury. CONCLUSION: The final diagnosis was primary intraosseous osteolytic meningioma with atypical pathology. Here, we report a rare case of an osteolytic skull lesion in the skull base not invading the dura and with extensive bone destruction.


Assuntos
Neoplasias Meníngeas/cirurgia , Meningioma/cirurgia , Neoplasias Cranianas/cirurgia , Idoso de 80 Anos ou mais , Dura-Máter/patologia , Humanos , Imagem por Ressonância Magnética , Masculino , Neoplasias Meníngeas/diagnóstico , Meningioma/diagnóstico , Osteólise , Osso Petroso/patologia , Osso Petroso/cirurgia , Neoplasias Cranianas/diagnóstico
8.
Medicine (Baltimore) ; 98(17): e15443, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31027147

RESUMO

RATIONALE: Plasmacytoma as the 1st presentation of skull tumors is a rare disorder. When it is combined with brain trauma or dramatic changes in intracranial pressure, patients are more prone to misdiagnosis. PATIENT CONCERNS: A 67-year-old woman complaining of a headache presented with a history of head trauma for the past 1 hour. Emergency head computed tomography initially suggested an epidural hematoma. DIAGNOSIS: Emergency surgery was performed to remove the intracranial hematoma, but a tumor-like mass was found during surgery, and pathologic assessment confirmed plasmacytoma. Surgery was difficult because of bleeding. The tumor was radically removed. INTERVENTIONS AND OUTCOMES: The patient underwent whole-brain radiotherapy and chemotherapy. She died 40 months after the surgery. LESSONS: Epidural lesions found after a head injury may be assumed to be an epidural hematoma, leading to unnecessary surgery. Diseases such as hematomas, meningiomas, eosinophilic granulomas, bone metastases, and osteosarcomas must be considered.


Assuntos
Traumatismos Craniocerebrais/diagnóstico , Hematoma Epidural Craniano/diagnóstico , Plasmocitoma/diagnóstico , Neoplasias Cranianas/diagnóstico , Idoso , Traumatismos Craniocerebrais/complicações , Traumatismos Craniocerebrais/terapia , Diagnóstico Diferencial , Evolução Fatal , Feminino , Hematoma Epidural Craniano/cirurgia , Humanos , Plasmocitoma/patologia , Plasmocitoma/terapia , Neoplasias Cranianas/patologia , Neoplasias Cranianas/terapia
9.
J Fr Ophtalmol ; 42(5): 485-491, 2019 May.
Artigo em Francês | MEDLINE | ID: mdl-30926270

RESUMO

Meningiomas represent about 20% of intracranial tumors. Involvement of the medial sphenoid wing includes anterior clinoid, cavernous sinus and superior orbital fissure meningiomas. Due to the proximity of these tumors to the optic nerve, typically progressive unilateral vision loss, over several months to years, is the classic clinical presentation. We report three cases of acute monocular vision loss, two transient and one permanent, ipsilateral to a sphenoid meningioma. Ophthalmological involvement with sphenoid meningiomas is most often chronic, due to interruption of axoplasmic flow and demyelination of the optic nerve by local compression. However, vascular involvement with ischemia of the optic nerve or transient low blood flow secondary to compression of the carotid branches vascularizing these structures is another possible mechanism. In our series, two patients had amaurosis fugax, and one patient had sudden, persistent visual loss in relation to acute anterior ischemic optic neuropathy on the side of the meningioma. The mean age of patients with acute visual manifestations was 62 years. These ischemic and non-compressive visual symptoms, ipsilateral to sphenoid meningiomas, are difficult to interpret. Whether these temporary visual disturbances of vascular origin should be considered an early sign of future severe or permanent visual impairment when no optic nerve compression is observed is not certain. The place of these acute visual disturbances in the therapeutic decision, particularly surgical, remains to be defined. Larger multicentric prospective studies are needed to better understand the role of local circulatory factors attributable to meningioma in the occurrence of these acute visual signs.


Assuntos
Neoplasias Meníngeas/complicações , Meningioma/complicações , Neoplasias Cranianas/complicações , Osso Esfenoide/patologia , Transtornos da Visão/etiologia , Doença Aguda , Idoso , Cegueira/diagnóstico , Cegueira/etiologia , Feminino , Humanos , Masculino , Neoplasias Meníngeas/diagnóstico , Meningioma/diagnóstico , Pessoa de Meia-Idade , Neoplasias Cranianas/diagnóstico , Transtornos da Visão/diagnóstico
10.
World Neurosurg ; 126: e1140-e1146, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30880192

RESUMO

BACKGROUND: Clear cell sarcoma (CCS) is a rare malignant soft tissue tumor with poor prognosis owing to metastasis and insensitive response to chemotherapy and radiotherapy. METHODS: We first searched PubMed and Embase using the terms "clear cell sarcoma," "malignant melanoma of soft tissue," "head," and "neck." In the 15 articles selected for literature review, only 27% (4/15) of patients were diagnosed with primary CCS of the head. Pathologically, those tumors arose from either the scalp or the superficial temporal fascia, but none invaded the skull and brain. Next, the search was performed in the same database using the terms "clear cell sarcoma," "malignant melanoma of soft tissue," and "bone," and only 24 articles were selected. RESULTS: In the case reported here, a 36-year-old woman was found to have a palpable mass located at the left temporal-occipital region, and surgical finding confirmed the invasion into the skull and the brain. The diagnosis of primary CCS was made because of the detection of t(12;22)(q13;q12) in >50% of tumor cells by fluorescence in situ hybridization, and metastasis to the lymph nodes and lungs was discovered by postoperative positron emission tomography-computed tomography. CONCLUSIONS: To the best of our knowledge, this is the first case of primary central nervous system CCS. Primary CCS may involve the skull and should be one of the differential diagnoses for intra-extracranial communicating tumors. Further research on biological characteristics and molecular targeted therapy of CCS are needed to improve its poor prognosis.


Assuntos
Neoplasias Encefálicas/patologia , Sarcoma de Células Claras/patologia , Neoplasias Cranianas/patologia , Adulto , Neoplasias Encefálicas/diagnóstico , Neoplasias Encefálicas/genética , Feminino , Humanos , Neoplasias Pulmonares/secundário , Metástase Linfática/patologia , Sarcoma de Células Claras/diagnóstico , Sarcoma de Células Claras/genética , Neoplasias Cranianas/diagnóstico , Neoplasias Cranianas/genética , Translocação Genética
12.
BMC Cancer ; 19(1): 172, 2019 Feb 25.
Artigo em Inglês | MEDLINE | ID: mdl-30803439

RESUMO

BACKGROUND: Primary intraosseous cavernous hemangiomas (PICHs) of the skull are extremely rare. To date, diffuse cranial hemangioma of skull has not been reported. In cancer patients, it is often misdiagnosed as metastasis. CASE PRESENTATION: Here, we presented a case of a 50-year-old female patient suffering from slightly headache who received breast cancer modified radical mastectomy in 2004, computed tomography and magnetic resonance imaging findings revealed abnormal lesions of diffuse skull which were misdiagnosed as skull metastasis, and the relevant literatures were also reviewed. CONCLUSIONS: Diffuse cavernous hemangioma of the skull is exceedingly rare, and imaging data are not typical. The condition is often misdiagnosed, and pathological evaluation is necessary and important. In cases where the mass cannot be completely removed by surgery, radiotherapy could be beneficial.


Assuntos
Neoplasias da Mama/diagnóstico , Hemangioma Cavernoso/diagnóstico , Neoplasias Cranianas/diagnóstico , Crânio/patologia , Neoplasias da Mama/patologia , Diagnóstico Diferencial , Erros de Diagnóstico , Feminino , Hemangioma Cavernoso/patologia , Humanos , Imagem por Ressonância Magnética , Pessoa de Meia-Idade , Metástase Neoplásica , Crânio/diagnóstico por imagem , Neoplasias Cranianas/patologia , Tomografia Computadorizada por Raios X
13.
Orbit ; 38(2): 154-157, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29557698

RESUMO

We report a case of myeloid sarcoma with multifocal skeletal involvement, including the greater wing of the sphenoid bone. A 23-month-old boy presented with left-sided proptosis and fevers, and was found to have an infiltrative mass involving the left sphenoid bone on orbital imaging. Full body imaging further demonstrated multiple bony lesions in the pelvis, thoracic and lumbar vertebrae, bilateral femura, and left humerus, and biopsies of the humerus were consistent with myeloid sarcoma. The patient was started on a standard chemotherapy regimen and is responding well. Myeloid sarcoma presenting with proptosis due to sphenoid bone involvement with simultaneous multifocal skeletal involvement is very uncommon and highlights the importance of biopsy for establishing a definitive diagnosis.


Assuntos
Neoplasias Ósseas/diagnóstico , Exoftalmia/diagnóstico , Febre/diagnóstico , Neoplasias Primárias Múltiplas/diagnóstico , Sarcoma Mieloide/diagnóstico , Neoplasias Cranianas/diagnóstico , Osso Esfenoide/patologia , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Biomarcadores Tumorais/metabolismo , Neoplasias Ósseas/tratamento farmacológico , Neoplasias Ósseas/metabolismo , Humanos , Lactente , Imagem por Ressonância Magnética , Masculino , Proteínas de Neoplasias/metabolismo , Neoplasias Primárias Múltiplas/tratamento farmacológico , Neoplasias Primárias Múltiplas/metabolismo , Sarcoma Mieloide/tratamento farmacológico , Sarcoma Mieloide/metabolismo , Neoplasias Cranianas/tratamento farmacológico , Neoplasias Cranianas/metabolismo , Tomografia Computadorizada por Raios X
14.
J Cutan Pathol ; 46(1): 62-66, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30251332

RESUMO

Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder resulting from dysregulated clonal proliferation of Langerhans cells. Reticulohistiocytosis (RH) is another rare histiocytosis caused by the proliferation of histiocytes other than Langerhans cells. Co-existence of LCH and RH in different organs and in the same skin area has not been reported. We present the case of a 20-year-old woman who initially had co-existing bone LCH and cutaneous RH. After 1 year of chemotherapy with cytarabine, bone LCH significantly improved but cutaneous LCH developed in the same area where cutaneous RH was, resulting in hybrid LCH and RH of the skin. This unique history provides some evidence to support the theory that LCH and RH originate from the same stem cells and subsequently develop into hybrid LCH and RH of the skin in a cytokine environment influenced by chemotherapy. Repeat skin biopsies may be considered for adjusting treatment regimens in LCH patients whenever pre-existing skin lesions progress.


Assuntos
Citarabina/administração & dosagem , Neoplasias de Cabeça e Pescoço , Histiocitose de Células de Langerhans , Histiocitose de Células não Langerhans , Neoplasias Cutâneas , Neoplasias Cranianas , Adulto , Feminino , Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/tratamento farmacológico , Neoplasias de Cabeça e Pescoço/metabolismo , Neoplasias de Cabeça e Pescoço/patologia , Histiocitose de Células de Langerhans/diagnóstico , Histiocitose de Células de Langerhans/tratamento farmacológico , Histiocitose de Células de Langerhans/metabolismo , Histiocitose de Células de Langerhans/patologia , Histiocitose de Células não Langerhans/diagnóstico , Histiocitose de Células não Langerhans/tratamento farmacológico , Histiocitose de Células não Langerhans/metabolismo , Histiocitose de Células não Langerhans/patologia , Humanos , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Cutâneas/metabolismo , Neoplasias Cutâneas/patologia , Neoplasias Cranianas/diagnóstico , Neoplasias Cranianas/tratamento farmacológico , Neoplasias Cranianas/metabolismo , Neoplasias Cranianas/patologia
16.
Med Sci (Paris) ; 34 Focus issue F1: 20-25, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30403170

RESUMO

Gardner's syndrome (GS) is an autosomal dominant disease characterized by the presence of familial adenomatous polyposis (FAP) as well as extraintestinal manifestations such as osteomas, dental anomalies, epidermoid cysts and ocular abnormalities. These intestinal polyps carry a 100% risk of malignant change, so early diagnosis is crucial. As craniofacial osteomas and dental anomalies of GS usually precede gastrointestinal symptoms, otolaryngologists, oral surgeons and dentists play an important role in the diagnosis of GS. GS is extensively reported in literature in the Caucasian race but not in the Mongoloid race. We report a case of a 22-year-old patient with a manifestation of three features of GS - multiple osteomas, soft tissue tumors and dental anomalies in the craniofacial region, with no intestinal polyps at the time of reporting. A family pedigree with our patient as the proband was constructed and revealed 3 consecutive generations in his lineage with GS.


Assuntos
Polipose Adenomatosa do Colo/diagnóstico , Síndrome de Gardner/diagnóstico , Osteoma/diagnóstico , Neoplasias Cranianas/diagnóstico , Anormalidades Dentárias/diagnóstico , Polipose Adenomatosa do Colo/complicações , Polipose Adenomatosa do Colo/patologia , Adulto , Grupo com Ancestrais do Continente Asiático , Diagnóstico Diferencial , Família , Síndrome de Gardner/complicações , Síndrome de Gardner/patologia , Humanos , Masculino , Osteoma/etiologia , Linhagem , Neoplasias Cranianas/etiologia , Tomografia Computadorizada por Raios X , Anormalidades Dentárias/complicações , Adulto Jovem
17.
Medicine (Baltimore) ; 97(42): e12803, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30334973

RESUMO

RATIONALE: Osteoblastoma is an uncommon primary bone tumor that involves any part of the skeleton. But its occurrence in the skull is extremely rare. PATIENTS CONCERNS: A 30-year-old female was admitted to our hospital, because of the mass in the right frontal region with the history of headache for 3 years without nausea or vomiting. DIAGNOSIS: Initial differential diagnoses included hemangiopericytoma, atypical intraosseous meningioma, calvarial osteosarcoma, fibrous dysplasia, and histiocytosis, based on the results of enhanced CT and MRI. INTERVENTIONS: A total surgical resection of the mass was performed. OUTCOMES: Postoperative histopathologic analysis demonstrated the typical features of osteoblastoma, the benign bone neoplasm. Serial radiologic examination did not show recurrence in the 6 months follow-up. LESSONS: The radiologic appearance of the osteoblastoma is always confusing and makes the diagnosis difficult. We hope our case can give some clinical clues for the diagnosis and management of the disease.


Assuntos
Osso Frontal/patologia , Osteoblastoma/diagnóstico , Neoplasias Cranianas/diagnóstico , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Osteoblastoma/patologia , Córtex Pré-Frontal/patologia , Neoplasias Cranianas/patologia
18.
Pediatr Dermatol ; 35(6): e389-e390, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30178566

RESUMO

Melanotic neuroectodermal tumors of infancy are rare tumors arising from the neural crest and typically present during the first 12 months of life. The majority involve the facial bones, although melanotic neuroectodermal tumors of infancy of the skull and extremities have been observed with less frequency, as in the present case. This entity may initially be presented to the dermatologist as a scalp mass and should be considered in the differential diagnosis of infants with rapidly growing head and neck lesions.


Assuntos
Tumor Neuroectodérmico Melanótico/diagnóstico , Neoplasias Cranianas/diagnóstico , Diagnóstico Diferencial , Humanos , Lactente , Imagem por Ressonância Magnética , Masculino , Tumor Neuroectodérmico Melanótico/cirurgia , Crânio/patologia , Neoplasias Cranianas/patologia
19.
Gen Dent ; 66(5): e1-e4, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30188863

RESUMO

Osteomas are benign, asymptomatic fibro-osseous tumors that are most commonly observed in the paranasal sinuses and sometimes are found in imaging examinations that were taken for other reasons. Giant osteomas are rarely found in the frontal and ethmoid sinuses but, when they are, they may cause intracranial and orbital complications. The aims of this case report are to describe a frontoethmoid osteoma in a 40-year-old woman, discuss the characteristics of this lesion through cone beam computed tomography (CBCT) imaging, and review the options for treatment. A CBCT examination performed for the purpose of orthodontic diagnosis revealed the presence of a large, well-defined, lobular, hyperdense mass that occupied a sizeable area of the frontal sinus and extended to the ethmoid sinus. The patient did not report any pain. Based on the physical and imaging characteristics of the mass, the location and size of the lesion, and the patient's age, the diagnosis was a giant frontoethmoid osteoma. Due to its enhanced field of view, CBCT may enable earlier diagnosis of lesions that affect the maxillofacial region.


Assuntos
Osso Etmoide , Osso Frontal , Osteoma/diagnóstico , Neoplasias Cranianas/diagnóstico , Adulto , Tomografia Computadorizada de Feixe Cônico , Osso Etmoide/diagnóstico por imagem , Feminino , Osso Frontal/diagnóstico por imagem , Humanos , Osteoma/diagnóstico por imagem , Osteoma/cirurgia , Osteoma/terapia , Neoplasias Cranianas/diagnóstico por imagem , Neoplasias Cranianas/cirurgia , Neoplasias Cranianas/terapia
20.
World Neurosurg ; 119: 20-24, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30075263

RESUMO

BACKGROUND: Intraosseous hemangioma is a rare bone tumor, accounting for 0.7%-1.0% of all bone tumors. It can occur at any age, but only 9% of cases are younger than 10 years old. Although this tumor is usually slow-growing and clinically silent, we experienced 2 pediatric patients undergoing surgery for skull hemangioma who presented with uncommon clinical manifestations. CASE DECRIPTION: Case 1 was a 9-year-old boy who presented with sudden onset of headache and was referred to our hospital. Radiologic images revealed an osteolytic oval lesion in the right parietal bone and acute subdural hemorrhage in the right cerebral hemisphere. The right parietal lesion was removed surgically. The lesion was found to have grown into the dura and to be adherent to the pia matter. The removed lesion was histologically confirmed to be a hemangioma. Case 2 was an 8-year-old girl who was referred to our hospital with an elastic mass that had been slowly enlarging for 7 years. Radiologic images revealed an osteolytic oval lesion in the right parietal bone. Surgical removal was thus planned. The lesion was found to be attached to the dura, and we removed the lesion with the surrounding bone and attached dura. Histologic examination confirmed the lesion to be a hemangioma. CONCLUSIONS: Although skull hemangiomas show clinical heterogeneity, surgical removal is usually diagnostic and leads to good patient outcomes. On occasion, however, this tumor causes secondary changes in the dura, such that dural incision and dural plasty should be planned in advance of lesion removal.


Assuntos
Hemangioma/diagnóstico , Hemangioma/cirurgia , Neoplasias Cranianas/diagnóstico , Neoplasias Cranianas/cirurgia , Criança , Diagnóstico Diferencial , Feminino , Hemangioma/patologia , Humanos , Masculino , Crânio/diagnóstico por imagem , Crânio/patologia , Neoplasias Cranianas/patologia
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