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1.
BMJ Case Rep ; 14(1)2021 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-33431441

RESUMO

Taboo surrounding cancer has continued to be a stubborn and refractory public health issue especially in South Asian countries. Disparities in cancer care remain ubiquitous. Differences in the manner in which cancer is perceived, addressed, and treated might partly be a result of varying cultural influences. This case report highlights the clinical course of a female patient with neurofibromatosis who later developed a large facial malignant peripheral nerve sheath tumour. The case particularly addresses the catastrophic impact of the 'cancer-related social taboos' on various dimensions of cancer care ranging from primary and secondary prevention to definitive management. The financial issues in low-income to medium-income groups as potential deterrents to optimum treatment have also been highlighted. Approach to the common challenges faced by an oncologist practising in a society plagued by misconceptions about health and disease and potential remedial measures to debunk these myths have also been discussed.


Assuntos
Neoplasias Faciais/diagnóstico , Conhecimentos, Atitudes e Prática em Saúde/etnologia , Neurofibromatoses/diagnóstico , Tabu , Adulto , Progressão da Doença , Neoplasias Faciais/etnologia , Feminino , Humanos , Índia , Neurofibromatoses/etnologia
7.
Med J Malaysia ; 74(5): 447-449, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31649228

RESUMO

PHACE syndrome describes the association of large segmental haemangioma with extracutaneous features (posterior fossa anomalies, arterial, cardiac, eye and endocrine anomalies). We report a case of segmental facial infantile haemangioma with PHACE syndrome treated successfully with oral propranolol without neurological sequelae.


Assuntos
Coartação Aórtica/complicações , Anormalidades do Olho/complicações , Neoplasias Faciais/etiologia , Hemangioma/etiologia , Síndromes Neurocutâneas/complicações , Propranolol/administração & dosagem , Administração Oral , Antagonistas Adrenérgicos beta/administração & dosagem , Progressão da Doença , Neoplasias Faciais/diagnóstico , Neoplasias Faciais/tratamento farmacológico , Hemangioma/diagnóstico , Hemangioma/tratamento farmacológico , Humanos , Recém-Nascido , Masculino
8.
Acta Dermatovenerol Croat ; 27(3): 146-152, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31542057

RESUMO

The differential diagnosis of lentigo maligna (LM) from pigmented actinic keratosis (PAK) and solar lentigines (SL) remains a challenge for clinicians, especially in the early stages of LM when there are no distinctive dermoscopic features. Objective of this study was to evaluate the frequencies of selective dermoscopic criteria in LM, PAK, and SL and to find the specific combination of distinguishing dermoscopic criteria for LM. Dermoscopists blinded to histopathological diagnosis evaluated 42 LM, 107 PAK, and 16 SL for the presence of predefined dermoscopic criteria. The differences in the presence of dermoscopic criteria between LM and others were evaluated with the chi-squared test or Fisher's exact test as appropriate. Multivariate logistic regression analysis with the forward conditional stepwise method were performed and odds ratios and corresponding 95% confidence intervals for LM, PAK, and SL were calculated. LM, PAK, and SL showed many common dermoscopic findings. In multivariate logistic regression analysis, darkening at dermoscopic examination (sevenfold), gray circles (sevenfold), target-like pattern (sixfold), gray rhomboids (sixfold), and slate-gray dots/globules (threefold) represented the strongest predictors of LM, while hyperkeratosis (thirteenfold), white circles (twelvefold), and red rhomboids (sixfold) represented the strongest predictors of PAK. The dermoscopic diagnosis of a given lesion should be based on the presence of the combination of specific dermoscopic criteria rather than a single benign or malignant criterion. Our results suggest that the presence of darkening at dermoscopic examination, gray circles, target-like pattern, gray rhomboids, and slate-gray dots/globules should be considered supportive findings for the diagnosis of early LM.


Assuntos
Dermoscopia , Neoplasias Faciais/diagnóstico , Sarda Melanótica de Hutchinson/diagnóstico , Ceratose Actínica/diagnóstico , Lentigo/diagnóstico , Neoplasias Cutâneas/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
12.
J Cancer Res Ther ; 15(3): 608-614, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31169228

RESUMO

Objective: This study aims to determine the clinical features which are helpful as significant indicators in the diagnosis of malignant and nonmalignant nonodontogenic orofacial tumors. Materials and Methods: This was a prospective study performed on patients with swellings in the oral and maxillofacial region clinically suspicious of being tumors of nonodontogenic origin in a Nigerian Tertiary Health Institution. The statistical variables that were analyzed included patients' resume, clinical and radiological features as well as the histopathological diagnosis of the lesions. The level of significance was set at P < 0.05. Inferential analysis was done using Student's t-test, Chi-square, binary logistic regression, and adjusted odds ratio as appropriate. Results: There were forty patients histopathologically diagnosed as nonodontogenic tumors of the orofacial region. Twenty-five (62.5%) were females and 15 (37.5%) were males with mean age of 36 ± 21.9 years. Histopathological features showed three different categories of the lesions: Reactive and benign (nonmalignant) and the malignant lesions. Lymphadenopathy (P = 0.035) and nonmobility of the swellings (P = 0.029) were significant clinical indicators that were strongly associated with histological diagnosis of the malignant nonodontogenic tumors. Conclusion: This study showed that the nonodontogenic tumors occurred mostly in younger patients with a female preponderance. The mandible and the preauricular region were the most common sites. Lymphadenopathy and nonmobility of the swellings were strong clinical indicators for the diagnosis of the malignant nonodontogenic tumors.


Assuntos
Neoplasias Faciais/diagnóstico , Neoplasias Bucais/diagnóstico , Adolescente , Adulto , Idoso , Biópsia , Criança , Pré-Escolar , Neoplasias Faciais/patologia , Feminino , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/patologia , Gradação de Tumores , Estadiamento de Neoplasias , Radiografia , Avaliação de Sintomas , Adulto Jovem
13.
Skinmed ; 17(2): 124-126, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31145066

RESUMO

An otherwise healthy 34-year-old man presented to our clinic with a small nonhealing, tender papule that had appeared on his face 9 months previously. His family history and past medical history were unremarkable. There was no history of trauma. Cutaneous examination revealed a small erythematous papule 0.5 cm in diameter on the left preauricular region (Figure 1). There was no regional lymphadenopathy, and he was in a generally good condition.


Assuntos
Neoplasias Faciais/diagnóstico , Leiomiossarcoma/diagnóstico , Neoplasias Cutâneas/diagnóstico , Adulto , Bochecha , Neoplasias Faciais/patologia , Humanos , Leiomiossarcoma/patologia , Masculino , Neoplasias Cutâneas/patologia
14.
Dermatol Online J ; 25(4)2019 Apr 15.
Artigo em Inglês | MEDLINE | ID: mdl-31046907

RESUMO

Tissue-sparing biopsy techniques are frequently used in clinical practice but can result in misdiagnosis of large, clinically challenging lesions. We present a case of a 70-year-old man with hidradenocarcinoma of the left chin, a diagnosis that was delayed owing to repeated superficial biopsies that were negative for disease. Diagnosis was ultimately obtained via an incisional biopsy. We discuss the clinical features of hidradenocarcinoma and why this diagnosis can be easily missed with superficial biopsies. It is important that dermatologists consider incisional biopsies in the workup of clinically challenging lesions for which malignancy is considered.


Assuntos
Acrospiroma/diagnóstico , Acrospiroma/patologia , Neoplasias Faciais/diagnóstico , Neoplasias Faciais/patologia , Neoplasias das Glândulas Sudoríparas/diagnóstico , Neoplasias das Glândulas Sudoríparas/patologia , Idoso , Biópsia/métodos , Queixo , Humanos , Masculino
15.
Int J Pediatr Otorhinolaryngol ; 123: 191-194, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31129458

RESUMO

INTRODUCTION: Pleomorphic myxoid liposarcoma is a rare and aggressive cancer seen in the pediatric population that has been previously associated with hereditable cancer disorders like Li Fraumeni syndrome. We present a case report and review of the relevant literature. CASE PRESENTATION: Pleomorphic myxoid liposarcoma presenting as a second primary tumor in a child with a strong family history for cancer led to diagnosis of Li-Fraumeni syndrome, which is associated with TP53 tumor suppressor gene inactivation. MANAGEMENT AND OUTCOME: The tumor was fully excised, but postoperative radiation was deferred to limit future radiation-induced tumorgenesis. DISCUSSION: Pleomorphic myxoid liposarcoma is rare but aggressive, and should prompt caregivers to test for potential hereditable cancer disorders. Li-Fraumeni syndrome is associated with early onset neoplasia and development of recurrent primary tumors. Its presence affects treatment decisions and methods of surveillance. Chemoradiation should be used judiciously in this population.


Assuntos
Neoplasias Faciais/diagnóstico , Síndrome de Li-Fraumeni/complicações , Lipossarcoma Mixoide/diagnóstico , Criança , Neoplasias Faciais/etiologia , Neoplasias Faciais/terapia , Humanos , Síndrome de Li-Fraumeni/diagnóstico por imagem , Síndrome de Li-Fraumeni/patologia , Lipossarcoma Mixoide/etiologia , Lipossarcoma Mixoide/terapia , Imagem por Ressonância Magnética , Masculino
16.
J Investig Med High Impact Case Rep ; 7: 2324709619836695, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30938171

RESUMO

Merkel cell carcinoma (MCC) is a rare, rapidly growing, aggressive neuroendocrine skin cancer that generally arises on sun-exposed areas of body such as head, neck, upper limbs, and shoulders of people with light complexity. Typically, MCC presents as shiny, flesh-colored or bluish-red, intracutaneous nodule, possibly with ulceration or crusting. In most of the cases, there is an association with Merkel cell polyomavirus. Even though these are very aggressive tumors, early detection and treatment has always given favorable outcome. There seems to be no consensus in definite prognostic markers, and advanced stages have the worst outcome even with treatment. There has been a recent trend in using PD-I/PD-L1 target therapy rather than chemotherapy in these cancers and have shown to improve survival by many months. In this article, we report a very unusual presentation of MCC first found on left frontoparietal skull as an 8-cm diameter fixed, subcutaneous mass without any typical features of MCC and was found to have metastatic spread to lung and liver. The patient was treated with palliative radiotherapy to brain and chemotherapy with cisplatin/etoposide with addition of immunotherapy later.


Assuntos
Carcinoma de Célula de Merkel/diagnóstico , Neoplasias Faciais/diagnóstico , Infecções por HIV/complicações , Neoplasias Cutâneas/diagnóstico , Carcinoma de Célula de Merkel/complicações , Carcinoma de Célula de Merkel/terapia , Terapia Combinada , Neoplasias Faciais/complicações , Neoplasias Faciais/terapia , Testa , Humanos , Imunoterapia , Imagem por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Neoplasias Cutâneas/complicações , Neoplasias Cutâneas/terapia , Tomografia Computadorizada por Raios X
17.
Acta Dermatovenerol Croat ; 27(1): 22-27, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31032787

RESUMO

Basal cell carcinoma (BCC) is the most frequent skin cancer and is characterized by slow growth, even if it can be locally invasive and rarely metastasizes. Many different phenotypic presentations and histopathologic subtypes have been described, and the current guidelines subdivide BCCs into low-risk (nodular and superficial) and high-risk subtypes (micronodular, infiltrating, and morphoeic BCC and those with squamous differentiation). Dermoscopy allows the identification of the features associated with these different subtypes. Compared with the low-risk forms of BCC, more aggressive ones tend to undergo more frequently incomplete surgical excision and perineural invasion, so the identification of these lesions before surgery is extremely important. The gold standard of treatment is surgery, particularly for the H region of the face and infiltrative lesions, but other options are available and selected according to many variables, including body area, age, comorbidities, and clinical, dermoscopic, and histopathological features of the lesion. Moreover, the possible complications of surgical approaches, namely healing defects, failure of skin grafts, and wound infection, should be considered. In this review we discuss the management of BCC localized on the face and scalp, according to the currently available treatment options.


Assuntos
Carcinoma Basocelular/diagnóstico , Carcinoma Basocelular/terapia , Neoplasias Faciais/terapia , Couro Cabeludo , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/terapia , Neoplasias Faciais/diagnóstico , Humanos
19.
Skinmed ; 17(1): 24-28, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30888944

RESUMO

Metatypical basal cell carcinoma (MBCC) represents a high-risk type of cutaneous tumor and has characteristics similar to basal cell carcinoma and squamous cell carcinoma. We report a retrospective study of 13 patients who presented with cervicofacial MBCC. Our study found an increased prevalence of aggressive clinicohistologic features and showed disease recurrences in more than one-third of the patients; therefore, we conclude that MBCC is an aggressive variant that requires a complex surgical approach for achieving a stable and complete remission. (SKINmed. 2019;17:24-28).


Assuntos
Carcinoma Basocelular/patologia , Neoplasias Faciais/patologia , Neoplasias Cutâneas/patologia , Idoso , Carcinoma Basocelular/diagnóstico , Carcinoma Basocelular/cirurgia , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/patologia , Neoplasias Faciais/diagnóstico , Neoplasias Faciais/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia , Prevalência , Estudos Retrospectivos , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/cirurgia
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