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1.
Am J Surg ; 219(5): 823-827, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32029218

RESUMO

INTRODUCTION: Atypical lipomatous tumors or well-differentiated liposarcomas (ALT/WDLS) are low-grade soft tissue tumors that are commonly located on the trunk and extremities. There is no consensus on the best surgical approach for ALT/WDLS. METHODS: A systematic literature review of PubMed, Medline, Embase, Scopus, and google scholar was performed. All published studies on trunk or extremities ALT/WDLS with reported outcome data were considered and independently screened for inclusion by at least two of the authors. RESULTS: A total of eighteen studies comprising 793 patients with ALT/WDLS were included. 580 patients underwent marginal excision, with local recurrence observed in 69 (11.9%). 213 patients underwent wide excision with local recurrence in 7(3.3%). Recurrent tumors were successfully re-resected with marginal or wide excision. Dedifferentiation was confirmed in 9 patients (1.1%), and a distant pulmonary metastasis in 1 patient (0.1%). DISCUSSION: Marginal excision of truncal or extremities ALT/WDLS results in a slightly higher local recurrence rate. However, recurrences are almost always amenable to re-resection. The findings support the use of marginal excision for truncal or extremities ALT/WDLS.


Assuntos
Extremidades/patologia , Neoplasias Lipomatosas/cirurgia , Neoplasias de Tecidos Moles/cirurgia , Tronco/patologia , Humanos , Lipossarcoma/patologia , Lipossarcoma/cirurgia , Recidiva Local de Neoplasia/patologia , Neoplasias Lipomatosas/patologia , Neoplasias de Tecidos Moles/patologia
2.
Pathologe ; 40(4): 339-352, 2019 Jul.
Artigo em Alemão | MEDLINE | ID: mdl-31240452

RESUMO

More than 20% of soft-tissue tumors belong to the group of adipocytic neoplasms. Difficulties may occur in the differential diagnosis of lipomas versus atypical lipomatous tumors/well-differentiated liposarcomas, in the distinction of dedifferentiated liposarcomas from other soft-tissue sarcoma entities and in the detailed subtyping of liposarcomas. Especially in biopsies, the correct diagnosis and grading may be hampered due to limited tissue. Because of the ever-increasing molecular-pathological knowledge of soft-tissue tumors and the rising distribution of molecular diagnostic assays in institutes of pathology, differential diagnosis has been facilitated, as more than 90% of adipocytic tumors carry more or less specific genomic alterations. In the following, the most important subtypes of adipocytic tumors are described morphologically and genomically.


Assuntos
Lipoma , Lipossarcoma , Neoplasias Lipomatosas , Sarcoma , Neoplasias de Tecidos Moles , Humanos , Lipoma/diagnóstico , Lipoma/patologia , Lipossarcoma/diagnóstico , Lipossarcoma/patologia , Neoplasias Lipomatosas/diagnóstico , Neoplasias Lipomatosas/patologia , Sarcoma/diagnóstico , Sarcoma/patologia , Neoplasias de Tecidos Moles/genética , Neoplasias de Tecidos Moles/patologia
4.
Semin Diagn Pathol ; 36(2): 129-141, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30853315

RESUMO

Myxoid adipocytic tumors encompass a broad heterogeneous group of benign and malignant adipocytic tumors, which are typically myxoid (e.g. myxoid liposarcoma, lipoblastoma and lipoblastoma-like tumor of the vulva) or may occasionally appear predominantly myxoid (e.g. pleomorphic liposarcoma, atypical lipomatous tumor, dedifferentiated liposarcoma, chondroid lipoma, spindle cell/pleomorphic lipoma, atypical spindle cell lipomatous tumor and atypical pleomorphic lipomatous tumor). There have been significant advances in recent years in classification and understanding the pathogenesis of adipocytic tumors, based on the correlation of histologic, immunohistochemical, and cytogenetic/molecular findings. Despite these advances, the morphologic diagnosis and accurate classification of a myxoid adipocytic tumor can be challenging due to major morphologic overlap between myxoid adipocytic and non-adipocytic tumors. This article will provide a review on the currently known morphological, immunohistochemical and molecular features of myxoid adipocytic tumors and their differential diagnosis.


Assuntos
Neoplasias Lipomatosas/diagnóstico , Neoplasias Lipomatosas/patologia , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/patologia , Diagnóstico Diferencial , Humanos
5.
Semin Diagn Pathol ; 36(2): 95-104, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30850231

RESUMO

Adipocytic neoplasms in the pediatric population demonstrate a different histologic spectrum and frequency than in adults. The vast majority of these tumors are benign, with lipoma being the most common entity. The identification of signature cytogenetic and molecular alterations for certain lesions, such as PLAG1 gene rearrangement in lipoblastoma and FUS-DDIT3 fusion in myxoid liposarcoma, has been helpful in approaching these neoplasms and aiding in confirming the diagnosis. Furthermore, it is important for pathologists to recognize that adipocytic neoplasms may be associated with different syndromes with potential impact in managing such patients. This review provides a summary of the clinical pictures, histologic characteristics, molecular alterations, differential diagnoses, and syndromic associations of the commonly encountered fatty tumors in children.


Assuntos
Neoplasias Lipomatosas/diagnóstico , Neoplasias Lipomatosas/patologia , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Neoplasias Lipomatosas/genética
8.
J Clin Pathol ; 71(6): 483-492, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29358476

RESUMO

This is a review of the morphological spectrum of fatty tumours containing a component of spindle cells, highlighting the immunohistochemical and cytogenetic workup that is now mandatory for accurate diagnosis, with the goal of providing a practical approach for practising surgical pathologists. There have been significant advances in recent years in classifying and understanding the pathogenesis of fatty tumours with spindle cells, based on the correlation of histological, immunohistochemical and cytogenetic/molecular findings. In spite of this, morphological diagnosis and accurate classification of fatty tumours with spindle cells can be challenging to diagnostic pathologists. A group of three lesions: spindle cell lipoma, mammary-type myofibroblastoma and cellular angiofibroma share morphological features and are united by retinoblastoma protein (pRb) loss. Closely allied to these lesions, especially spindle cell lipoma is the newly designated atypical spindle cell lipomatous tumour, which shares morphological, immunohistochemical and cytogenetic features with the trio of tumours lacking nuclear pRb. All of these lesions lack MDM2 and CDK4 amplification as well and separation is based on clinical features, principally location. Atypical lipomatous tumour or well-differentiated liposarcoma shows retention of pRb but overexpression and amplification of MDM2. Fatty tumours with spindle cells need to be extensively sampled, with careful attention paid to cellular atypia and location, and they need to have immunohistochemical workup with pRb, MDM2, desmin, CD34 and p16. In addition, cytogenetic analysis for MDM2 and CDK4 amplification has become crucial for the proper identification of these lesions.


Assuntos
Tecido Adiposo/patologia , Neoplasias Lipomatosas/patologia , Tecido Adiposo/metabolismo , Biomarcadores Tumorais/genética , Biomarcadores Tumorais/metabolismo , Biópsia , Diferenciação Celular , Amplificação de Genes , Regulação Neoplásica da Expressão Gênica , Humanos , Imuno-Histoquímica , Técnicas de Diagnóstico Molecular , Neoplasias Lipomatosas/genética , Neoplasias Lipomatosas/metabolismo , Valor Preditivo dos Testes
10.
Am J Physiol Cell Physiol ; 313(1): C108-C117, 2017 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-28515087

RESUMO

FXYD5 is a Na+-K+-ATPase regulator, expressed in a variety of normal epithelia. In parallel, it has been found to be associated with several types of cancer and effect lethal outcome by promoting metastasis. However, the molecular mechanism underlying FXYD5 mediated invasion has not yet been identified. In this study, using in vivo 4T1 murine breast cancer model, we found that FXYD5-specific shRNA significantly inhibited lung cancer metastasis, without having a substantial effect on primary tumor growth. Our study reveals that FXYD5 participates in multiple stages of metastatic development and exhibits more than one mode of E-cadherin regulation. We provide the first evidence that FXYD5-related morphological changes are mediated through its interaction with Na+-K+-ATPase. Experiments in cultured 4T1 cells have indicated that FXYD5 expression may downregulate the ß1 isoform of the pump. This behavior could have implications on both transcellular interactions and intracellular events. Further studies suggest that differential localization of the adaptor protein Annexin A2 in FXYD5-expressing cells may correlate with matrix metalloproteinase 9 secretion and adhesion changes in 4T1 wild-type cells.


Assuntos
Regulação Neoplásica da Expressão Gênica , Neoplasias Pulmonares/genética , Neoplasias Mamárias Experimentais/genética , Proteínas de Membrana/genética , Neoplasias Lipomatosas/genética , ATPase Trocadora de Sódio-Potássio/genética , Animais , Anexina A2/genética , Anexina A2/metabolismo , Caderinas/genética , Caderinas/metabolismo , Adesão Celular , Linhagem Celular Tumoral , Movimento Celular , Modelos Animais de Doenças , Feminino , Neoplasias Pulmonares/metabolismo , Neoplasias Pulmonares/secundário , Glândulas Mamárias Animais/metabolismo , Glândulas Mamárias Animais/patologia , Neoplasias Mamárias Experimentais/metabolismo , Neoplasias Mamárias Experimentais/patologia , Metaloproteinase 9 da Matriz/genética , Metaloproteinase 9 da Matriz/metabolismo , Proteínas de Membrana/antagonistas & inibidores , Proteínas de Membrana/metabolismo , Camundongos , Camundongos Endogâmicos BALB C , Neoplasias Lipomatosas/metabolismo , Neoplasias Lipomatosas/patologia , Subunidades Proteicas/genética , Subunidades Proteicas/metabolismo , RNA Interferente Pequeno/genética , RNA Interferente Pequeno/metabolismo , Transdução de Sinais , ATPase Trocadora de Sódio-Potássio/metabolismo
11.
Lasers Surg Med ; 49(3): 240-248, 2017 03.
Artigo em Inglês | MEDLINE | ID: mdl-28319274

RESUMO

BACKGROUND AND OBJECTIVE: Sarcomas are rare but highly aggressive tumors, and local recurrence after surgical excision can occur in up to 50% cases. Therefore, there is a strong clinical need for accurate tissue differentiation and margin assessment to reduce incomplete resection and local recurrence. The purpose of this study was to investigate the use of optical coherence tomography (OCT) and a novel image texture-based processing algorithm to differentiate sarcoma from muscle and adipose tissue. STUDY DESIGN AND METHODS: In this study, tumor margin delineation in 19 feline and canine veterinary patients was achieved with intraoperative OCT to help validate tumor resection. While differentiation of lower-scattering adipose tissue from higher-scattering muscle and tumor tissue was relatively straightforward, it was more challenging to distinguish between dense highly scattering muscle and tumor tissue types based on scattering intensity and microstructural features alone. To improve tissue-type differentiation in a more objective and automated manner, three descriptive statistical metrics, namely the coefficient of variation (CV), standard deviation (STD), and Range, were implemented in a custom algorithm applied to the OCT images. RESULTS: Over 22,800 OCT images were collected intraoperatively from over 38 sites on 19 ex vivo tissue specimens removed during sarcoma surgeries. Following the generation of an initial set of OCT images correlated with standard hematoxylin and eosin-stained histopathology, over 760 images were subsequently used for automated analysis. Using texture-based image processing metrics, OCT images of sarcoma, muscle, and adipose tissue were all found to be statistically different from one another (P ≤ 0.001). CONCLUSION: These results demonstrate the potential of using intraoperative OCT, along with an automated tissue differentiation algorithm, as a guidance tool for soft tissue sarcoma margin delineation in the operating room. Lasers Surg. Med. 49:240-248, 2017. © 2017 Wiley Periodicals, Inc.


Assuntos
Processamento de Imagem Assistida por Computador/métodos , Monitorização Intraoperatória/métodos , Neoplasias Musculares/patologia , Neoplasias Lipomatosas/diagnóstico por imagem , Sarcoma/diagnóstico por imagem , Tomografia de Coerência Óptica/métodos , Animais , Biópsia por Agulha , Gatos , Diagnóstico Diferencial , Cães , Imuno-Histoquímica , Margens de Excisão , Neoplasias Musculares/diagnóstico por imagem , Neoplasias Musculares/cirurgia , Neoplasias Musculares/veterinária , Neoplasias Lipomatosas/patologia , Neoplasias Lipomatosas/cirurgia , Neoplasias Lipomatosas/veterinária , Sarcoma/patologia , Sarcoma/cirurgia , Sarcoma/veterinária
12.
Nihon Shokakibyo Gakkai Zasshi ; 114(1): 84-90, 2017.
Artigo em Japonês | MEDLINE | ID: mdl-28070099

RESUMO

A 66-year-old man with recurrent stroke within a short period of time was referred to our department from the neurology department to rule out any malignancy. An endoscopic examination revealed a white depressed lesion in the body of the stomach, and computed tomography revealed a high-density area in the mesentery around the stomach. A mucosa-associated lymphoid tissue (MALT) lymphoma was detected from both the stomach biopsy and resected mesenteric specimen. Systemic chemotherapy was administered for the MALT lymphoma (Lugano classification stage IV). Cerebral infarction did not occur after the treatment. We concluded that Trousseau syndrome associated with the MALT lymphoma disseminated to the mesenteric adipose tissue. A MALT lymphoma has a small probability of occurring in Trousseau syndrome.


Assuntos
Linfoma de Zona Marginal Tipo Células B/complicações , Linfoma de Zona Marginal Tipo Células B/patologia , Mesentério , Neoplasias Lipomatosas/complicações , Neoplasias Lipomatosas/patologia , Neoplasias Peritoneais/complicações , Neoplasias Peritoneais/patologia , Acidente Vascular Cerebral/etiologia , Idoso , Protocolos de Quimioterapia Combinada Antineoplásica/administração & dosagem , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Ciclofosfamida/administração & dosagem , Humanos , Linfoma de Zona Marginal Tipo Células B/diagnóstico por imagem , Linfoma de Zona Marginal Tipo Células B/tratamento farmacológico , Masculino , Mesentério/diagnóstico por imagem , Invasividade Neoplásica , Neoplasias Lipomatosas/diagnóstico por imagem , Neoplasias Lipomatosas/tratamento farmacológico , Neoplasias Peritoneais/diagnóstico por imagem , Neoplasias Peritoneais/tratamento farmacológico , Prednisona/administração & dosagem , Recidiva , Rituximab/administração & dosagem , Síndrome , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Vincristina/administração & dosagem
13.
Appl Immunohistochem Mol Morphol ; 25(3): 168-177, 2017 03.
Artigo em Inglês | MEDLINE | ID: mdl-26808135

RESUMO

INTRODUCTION: Sarcomas are heterogeneous, and their treatment and prognosis are driven by the morphologic subtype and the clinical stage. Classic cytogenetics and fluorescence in situ hybridization (FISH) analysis play an important role in their diagnostic work up. MATERIALS AND METHODS: Forty-six cases of soft-tissue sarcoma were reviewed that underwent karyotyping and simultaneous FISH analysis at initial diagnosis. They included 10 dedifferentiated liposarcomas, 10 myxoid liposarcomas, and 14 synovial sarcomas. Six tumors were investigated for EWSR1 rearrangement. Six high-grade miscellaneous sarcomas were also examined. RESULTS: The dedifferentiated liposarcoma had complex karyotypes and MDM2 amplification by FISH, and of these, 5 tumors with myxoid changes also had complex signals for DDIT3. All but 4 myxoid liposarcomas had complex karyotypes, in addition to the characteristic translocation. FISH analysis displayed DD1T3 rearrangement. All synovial sarcomas except 1 recurrence had a t(X;18) translocation by karyotyping and FISH. The EWSR1 rearrangement was present in all extraskeletal myxoid chondrosarcomas, angiomatoid fibrous histiocytoma, atypical Ewing sarcoma, and a clear-cell sarcoma, all of which had characteristic karyotypes. Seven high-grade sarcomas had no specific karyotype or rearrangements for DDIT3, SS18, and EWSR1 by FISH. CONCLUSIONS: There is good correlation between karyotyping and FISH. Complex FISH signals found in dedifferentiated liposarcomas may be related to an increased chromosome 12 copy number and ploidy. Karyotyping is an important baseline standard for the quality assurance of newly developed FISH probes. It also provides a global view of chromosomal changes and the opportunity to investigate the role of other genetic alterations and potential therapeutic targets.


Assuntos
Neoplasias Lipomatosas/patologia , Sarcoma Sinovial/patologia , Sarcoma/genética , Humanos , Hibridização in Situ Fluorescente , Neoplasias Lipomatosas/genética , Estudos Retrospectivos , Sarcoma/patologia , Sarcoma Sinovial/genética
14.
Comp Med ; 66(5): 420-423, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27780010

RESUMO

A 10-y-old pigtail macaque presented with a subcutaneous, soft-tissue mass overlying the right stifle joint. Here we describe the clinical case and histopathologic and immunohistochemical analysis of this lesion. This case represents the first published report of juxtaarticular myxoma in a pigtail macaque.


Assuntos
Macaca nemestrina , Mixoma/patologia , Neoplasias Lipomatosas/patologia , Animais , Feminino , Mixoma/cirurgia , Neoplasias Lipomatosas/cirurgia
15.
Rev. esp. cir. oral maxilofac ; 38(2): 82-84, abr.-jun. 2016. ilus
Artigo em Espanhol | IBECS | ID: ibc-152484

RESUMO

El hibernoma es un tumor adiposo benigno que morfológicamente rememora la grasa fetal. Su presencia a nivel oral es excepcional. Presentamos un caso de hibernoma de cavidad oral, revisamos la entidad y mostramos los distintos diagnósticos diferenciales (AU)


A hibernoma is a benign adipose tumour that morphologically resembles foetal fat. Its presence at oral level is exceptional. A case of an oral cavity hibernoma is presented, with a review of the condition and a description of the different differencial diagnoses (AU)


Assuntos
Humanos , Feminino , Adulto , Lipoma/diagnóstico , Lipoma/patologia , Boca/patologia , Diagnóstico Diferencial , Hiperplasia/complicações , Hiperplasia/diagnóstico , Hiperplasia/patologia , Tecido Adiposo/patologia , Neoplasias Lipomatosas/patologia , Seguimentos
16.
Rev. clín. med. fam ; 8(3): 246-250, oct. 2015. ilus
Artigo em Espanhol | IBECS | ID: ibc-147616

RESUMO

La presencia de una tumoración en tejidos blandos es un motivo de consulta frecuente en Atención Primaria. Una historia clínica completa y una adecuada exploración física son fundamentales para detectar posibles lesiones malignas. Aunque los sarcomas de tejidos blandos pueden aparecer en cualquier lugar del cuerpo, la mayoría se presenta en extremidades o el abdomen. Son un grupo heterogéneo, poco frecuente, de tumores mesenquimales malignos, siendo los liposarcomas los sarcomas más frecuentes del adulto. La cirugía habitualmente es curativa, sola o combinada con radioterapia, con o sin quimioterapia. Preservar la funcionalidad del miembro es el principal objetivo del tratamiento. La detección precoz puede evitar al paciente una cirugía mayor e importantes complicaciones, por lo que debemos estar atentos a los signos clínicos de alarma. Presentamos el caso de una mujer de 54 años con un liposarcoma bien diferenciado, en cara lateral externa del muslo izquierdo (AU)


The presence of a mass involving soft tissues is a frequent reason of consultation in primary health care. A complete clinical history and an appropriate physical examination are fundamental in order to detect possible malignant lesions. Although soft-tissue sarcomas can arise anywhere in the body, the majority appear in the limbs or within the abdomen. Soft-tissue sarcomas are a heterogeneous group of rare malignant mesenchymal tumors, and liposarcomas are the most common sarcoma in adult life. Surgery is often curative, alone or in combination with radiotherapy, with or without chemotherapy, and preserving limb functionality is the goal of treatment. The relevance of early detection could save patients major surgery and serious complications, that is why clinical awareness of the alarm signs should be kept in mind. We present the case of a 54-year-old female with a well-differentiated liposarcoma involving the lateral aspect of the left thigh (AU)


Assuntos
Humanos , Feminino , Adulto , Neoplasias Lipomatosas/metabolismo , Neoplasias Lipomatosas/patologia , Atenção Primária à Saúde , Atenção Primária à Saúde/métodos , Sarcoma/patologia , Metástase Neoplásica/diagnóstico , Metástase Neoplásica/patologia , Leucocitose/metabolismo , Neoplasias Lipomatosas/complicações , Neoplasias Lipomatosas/diagnóstico , Atenção Primária à Saúde/classificação , Atenção Primária à Saúde/ética , Sarcoma/metabolismo , Metástase Neoplásica/tratamento farmacológico , Metástase Neoplásica/radioterapia , Leucocitose/complicações
18.
Pediatr Blood Cancer ; 62(11): 2025-8, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26146844

RESUMO

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) and primary cutaneous gamma delta T-cell lymphoma (PCGD-TCL) were initially both classified as subcutaneous panniculitis-like T-cell lymphoma. In 2008, SPTCL with alpha-beta T-cell receptor subtype was separated from primary cutaneous gamma delta T-cell lymphomas (PCGD-TCL). We report four pediatric cases that demonstrate the heterogeneity of each disease and show that PCGD-TCL in children can have an indolent course, whereas SPTCL can behave aggressively. Three patients had spontaneous, durable remissions without treatment, whereas the one patient with disease progression was treated successfully. Watchful waiting may thus be appropriate for initial management of children.


Assuntos
Linfoma de Células T/terapia , Neoplasias Lipomatosas/terapia , Paniculite , Adolescente , Pré-Escolar , Feminino , Humanos , Linfoma de Células T/genética , Linfoma de Células T/patologia , Neoplasias Lipomatosas/genética , Neoplasias Lipomatosas/patologia
19.
Ann Pathol ; 35(1): 71-85, 2015 Jan.
Artigo em Francês | MEDLINE | ID: mdl-25532684

RESUMO

The new World Health Organization (WHO) classification of soft tissue tumours was published in 2013, 11years after the previous edition. This new classification includes several changes: newly included sections (gastrointestinal stromal tumors…), newly recognized entities (pseudomiogenic haemangioendothelioma, haemosiderotic fibrolipomatous tumour…), and new genetic and molecular data leading to better understanding and definition of tumours, and are useful as diagnostic tools. This brief review summarizes changes in this new edition of the WHO classification of tumours of soft tissue.


Assuntos
Neoplasias de Tecidos Moles/classificação , Biomarcadores Tumorais , Diferenciação Celular , Tumores do Estroma Gastrointestinal/química , Tumores do Estroma Gastrointestinal/patologia , Humanos , Neoplasias Lipomatosas/química , Neoplasias Lipomatosas/classificação , Neoplasias Lipomatosas/patologia , Neoplasias da Bainha Neural/química , Neoplasias da Bainha Neural/patologia , Sarcoma/química , Sarcoma/classificação , Sarcoma/patologia , Neoplasias de Tecidos Moles/química , Neoplasias de Tecidos Moles/patologia , Organização Mundial da Saúde
20.
Ann Pathol ; 35(1): 41-53, 2015 Jan.
Artigo em Francês | MEDLINE | ID: mdl-25533918

RESUMO

Adipocytic tumors are the most common mesenchymal neoplasms, liposarcoma accounting for approximately 20% of soft tissue sarcomas. The differential diagnosis between benign and malignant tumors is often problematic and represents a significant proportion of consultation cases. The goal of this article is to review liposarcoma subtypes, the main benign adipocytic neoplasms: lipoblastoma, hibernoma, spindle/pleomorphic cell lipoma, chondroid lipoma, as well as non adipocytic neoplasms with a lipomatous component such as lipomatous solitary fibrous tumor, emphasizing on practical differential diagnosis issues, and immunohistochemical and molecular tools allowing their resolution.


Assuntos
Neoplasias Lipomatosas/patologia , Angiolipoma/diagnóstico , Angiolipoma/genética , Angiolipoma/patologia , Biomarcadores Tumorais , Diferenciação Celular , Aberrações Cromossômicas , Diagnóstico Diferencial , Humanos , Lipoblastoma/diagnóstico , Lipoblastoma/genética , Lipoblastoma/patologia , Lipoma/diagnóstico , Lipoma/genética , Lipoma/patologia , Lipossarcoma/diagnóstico , Lipossarcoma/genética , Lipossarcoma/patologia , Proteínas de Neoplasias/genética , Neoplasias Lipomatosas/classificação , Neoplasias Lipomatosas/diagnóstico , Neoplasias Lipomatosas/genética , Sarcoma/diagnóstico , Organização Mundial da Saúde
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