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1.
Anticancer Res ; 41(10): 5081-5087, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34593458

RESUMO

BACKGROUND: Pharmacological inhibition of osteoclast activity is an essential component of oncological therapy for patients with bone metastases. In rare cases, medication-related osteonecrosis of the jaws (MRONJ) is observed. MRONJ can cause bone defects not inferior to primary or metastatic jaw neoplasms. Oral examination of patients on osteoclast-inhibiting medication aims to identify risk factors at an early stage and to initiate therapy. The current focus on osteoclast-inhibiting drugs in the maxillofacial region is MRONJ. Effects of the substances other than MRONJ are rarely reported. CASE REPORT: The female patient with metastatic breast cancer had developed extensive osteolysis of the mandibular ramus at the time of initial diagnosis. The patient was treated with denosumab. Seven months later, a significant reduction in the mandibular osteolytic zone was recorded. However, known bone metastases from other sites had increased in size during multimodal therapy, and further metastases were recorded. CONCLUSION: Jaw metastasis can shrink under denosumab therapy.


Assuntos
Conservadores da Densidade Óssea/efeitos adversos , Neoplasias Ósseas/secundário , Neoplasias da Mama/tratamento farmacológico , Denosumab/efeitos adversos , Neoplasias Mandibulares/patologia , Adulto , Neoplasias Ósseas/induzido quimicamente , Neoplasias da Mama/patologia , Progressão da Doença , Feminino , Humanos , Neoplasias Mandibulares/induzido quimicamente , Prognóstico
2.
Pan Afr Med J ; 38: 386, 2021.
Artigo em Francês | MEDLINE | ID: mdl-34381530

RESUMO

Adenomatoid odontogenic tumor is a benign epithelial tumor which mainly affects young women. It usually occurs in the anterior portion of the upper jaw. Diagnosis can be clinically suspected in patients with cyst formation associated with retained tooth but histopathological confirmation is required. This study involved two patients aged 13 and 37 years, with no previous history, presenting after the occurrence of a swelling on the jaw and mandible. Anatomopathological examination of these lesions showed adenomatoid odontogenic tumor. This study highlights the anatomoclinical features, outcome and treatment of this type of tumor.


Assuntos
Ameloblastoma/diagnóstico , Neoplasias Maxilomandibulares/diagnóstico , Neoplasias Mandibulares/diagnóstico , Adolescente , Adulto , Ameloblastoma/patologia , Humanos , Neoplasias Maxilomandibulares/patologia , Masculino , Neoplasias Mandibulares/patologia
3.
Anticancer Res ; 41(8): 3983-3988, 2021 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-34281862

RESUMO

BACKGROUND: When assessing sharply delineated bone lesions of the mandibular angle on X-rays, numerous diagnoses must be considered. The static bone cavity (Stafne's bone cavity, SBC) is a harmless lingual bone depression of the mandibular angle that usually does not require any treatment. It is essential to differentiate this bone deformity from other lesions that may require treatment. CASE REPORT: The 22-year-old patient was referred for further diagnosis and therapy after osteolysis of the mandible was noticed on a panoramic view (PV). The location and size of the lesion was typical of SBC. Only the three-dimensional representation of the lesion on cone beam computed tomographs revealed an intraosseous lesion. Histological examination of the lesion provided evidence of a fibrous neoplasm. CONCLUSION: The typical image of SBC is ambiguous on plain radiographs such as PV. The radiological diagnosis of the lesion should be based on the representation of the region of interest in different planes.


Assuntos
Neoplasias Mandibulares/diagnóstico por imagem , Neoplasias de Tecido Conjuntivo/diagnóstico por imagem , Adulto , Tomografia Computadorizada de Feixe Cônico , Humanos , Masculino , Mandíbula/anormalidades , Mandíbula/diagnóstico por imagem , Mandíbula/patologia , Neoplasias Mandibulares/patologia , Neoplasias de Tecido Conjuntivo/patologia , Adulto Jovem
4.
BMC Vet Res ; 17(1): 55, 2021 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-33509193

RESUMO

BACKGROUND: Mandibular masses caused by inflammatory processes due to bacterial infections, most common with Actinomyces bovis, are well known in herbivors. This case represents a rare differential diagnosis to common inflammatory processes which cannot be distinguished from neoplasia without detailed histopathological examination. CASE PRESENTATION: A large unilateral mandibular mass of a free-ranging female adult red deer (Cervus elaphus elaphus) was submitted for pathological examination. The animal had been shot due to its poor body condition. Grossly, the mandibular mass showed gingival ulceration and necrosis. Histologically, irregular strands and islands of odontogenic epithelial cells and a matrix of dentin and osteoid-like material were found, leading to the diagnosis of an odontogenic tumor. Considering the animal's age the tumor was classified as odontoameloblastoma with secondary chronic purulent osteomyelitis. CONCLUSIONS: Odontogenic tumors are rare in domestic and wildlife species and so far have not been reported in red deer. In addition to the more common inflammatory processes of the mandibula and other neoplastic diseases of the oral cavity, odontogenic tumors represent a rare differential diagnosis that must be kept in mind especially when masked by inflammatory lesions.


Assuntos
Cervos , Neoplasias Mandibulares/veterinária , Tumores Odontogênicos/veterinária , Animais , Animais Selvagens , Diagnóstico Diferencial , Feminino , Mandíbula/patologia , Neoplasias Mandibulares/diagnóstico , Neoplasias Mandibulares/patologia , Tumores Odontogênicos/diagnóstico , Tumores Odontogênicos/patologia
5.
Pediatr Blood Cancer ; 68(4): e28918, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33507629

RESUMO

BACKGROUND: Although metastatic involvement of bony sites including cranial bones is common in neuroblastoma (NB), mandibular metastases (MM) are uncommon, and specific outcomes have not been reported upon in the modern therapeutic era. METHODS: In this retrospective study, medical records on patients with MM from NB were reviewed. Statistical analysis was performed using the Kaplan-Meier method. RESULTS: Of 29 patients, nine (31%) had MM at diagnosis, whereas in 20 (69%) MM were first detected at NB relapse at a median time of 26 (6-89) months from diagnosis. Median maximal diameter of lesions was 3 (range 0.8-4.9) cm. MM were unilateral in 83% of patients, with ascending ramus (55%) and mandibular body (38%) being the two most common sites. All patients received systemic chemotherapy, and 26 (93%) patients received radiotherapy to MM. At a median follow-up of 37.3 (24.2-219.5) months, eight of nine patients with MM at diagnosis did not experience mandibular progressive disease. Eighteen of 20 patients with MM at relapse received therapeutic radiotherapy; objective responses were noted in 78%. Seventy-two percent (5/18) had not experienced relapse within the radiation field at a median of 12 (2-276) months postradiotherapy. Dental findings at follow-up after completion of NB therapy included hypodontia, hypocalcification of enamel, and trismus. Median 3-year overall survival in patients with relapsed MM was 51 ± 12% months from relapse. CONCLUSION: MM when detected at diagnosis is associated with a prognosis similar to that for other skeletal metastases of NB. Radiotherapy is effective for control of MM detected both at diagnosis and relapse. Significant dental abnormalities posttherapy warrant regular dental evaluations and appropriate intervention.


Assuntos
Mandíbula/patologia , Neoplasias Mandibulares/secundário , Neuroblastoma/patologia , Adolescente , Adulto , Anodontia/etiologia , Criança , Pré-Escolar , Dentição , Feminino , Humanos , Lactente , Estimativa de Kaplan-Meier , Masculino , Mandíbula/efeitos dos fármacos , Mandíbula/efeitos da radiação , Neoplasias Mandibulares/tratamento farmacológico , Neoplasias Mandibulares/patologia , Neoplasias Mandibulares/radioterapia , Neuroblastoma/tratamento farmacológico , Neuroblastoma/radioterapia , Estudos Retrospectivos , Trismo/etiologia , Adulto Jovem
8.
Autops. Case Rep ; 11: e2020218, 2021. graf
Artigo em Inglês | LILACS | ID: biblio-1142406

RESUMO

The Numb Chin Syndrome (NCS) is defined as facial and oral numbness restricted to the mental nerve's distribution involving the lower lip, skin of the chin, or gingiva of the lower anterior teeth. Hypoesthesia can occur unilaterally or bilaterally. Although this syndrome is rare, its importance is related to the fact that it represents the clinical manifestations of malignant diseases. Breast cancer and non-Hodgkin lymphoma are the most common cause of NCS. The patient, a 58-year-old woman, treated for a Burkitt Lymphoma (BL) nine years ago, described a two-week history of change in sensitivity and pain in the chin region, without relief with the use of analgesics. She had no headache, speech disturbance, dysphagia, visual disturbance, or other neurological symptoms. No surgical intervention has been performed recently. The intraoral examination revealed a healthy oral mucosa and a small area adjacent to the right mental nerve region that was uncomfortable to palpation. No changes were found in the bone trabeculae at cone-beam computed tomography. The contrasted magnetic resonance features made it possible to identify a change in the mandibular body extending to the entire right side, coinciding with the patient's complaint, indicating a probable mandibular medullary invasion. The patient was submitted to a biopsy to rule out a possible recurrence of BL. The microscopic findings were consistent with the diagnosis of BL. The present report described a very unusual presentation of late recurrent BL nine years after the first treatment, which manifested as an NCS.


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Neoplasias Mandibulares/patologia , Linfoma de Burkitt/patologia , Recidiva , Linfócitos B , Hipestesia
9.
J Craniofac Surg ; 31(8): e766-e778, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33136909

RESUMO

Intraosseous lipomas are rare benign tumors of the bone, especially for the mandible. The etiology remains unclear, although several hypotheses have been proposed, such as trauma, blood vessel infarction, aging and inflammation. Clinically, the symptoms mainly depend on the location and size of the tumors. Radiographically, the lesions are usually radiolucent occasionally accompanied by radiopacity. The diagnosis is challenging, and histopathologic examination is necessary for definite diagnosis. Herein, the authors report an unusual patient with intraosseous lipoma in the mandibular condyle.


Assuntos
Lipoma/diagnóstico por imagem , Côndilo Mandibular/diagnóstico por imagem , Neoplasias Mandibulares/diagnóstico por imagem , Adulto , Feminino , Humanos , Lipoma/patologia , Lipoma/cirurgia , Côndilo Mandibular/patologia , Côndilo Mandibular/cirurgia , Neoplasias Mandibulares/patologia , Neoplasias Mandibulares/cirurgia , Tomografia Computadorizada por Raios X
10.
BMJ Case Rep ; 13(9)2020 Sep 09.
Artigo em Inglês | MEDLINE | ID: mdl-32912890

RESUMO

Ameloblastoma is a benign epithelial tumour and the most common odontogenic tumour, accounting for about 18% of cases. We present a patient to illustrate the first use of tomoelastography for quantitatively mapping tissue stiffness (shear wave speed) and fluidity (loss angle of the complex shear modulus) in a metastasised ameloblastoma of the left mandible. Tomoelastography maps clearly depicted the extent of the tumour by abnormally high values of stiffness and fluidity (1.73±0.23 m/s, 1.18±0.08 rad) compared with normal values in the contralateral mandible (1.04±0.09 m/s, 0.93±0.12 rad). Abnormal stiffness also revealed metastatic involvement of the neck lymph nodes (1.30±0.03 m/s vs 0.86±0.01 m/s). Taken together, stiffness and fluidity measured by tomoelastography can sensitively detect the presence and extent of bone tumours and metastatic spread to cervical lymph nodes.


Assuntos
Ameloblastoma , Técnicas de Imagem por Elasticidade/métodos , Neoplasias de Cabeça e Pescoço , Linfonodos/diagnóstico por imagem , Metástase Linfática/diagnóstico por imagem , Neoplasias Mandibulares , Esvaziamento Cervical/métodos , Ameloblastoma/diagnóstico por imagem , Ameloblastoma/patologia , Ameloblastoma/cirurgia , Tomografia Computadorizada de Feixe Cônico/métodos , Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/patologia , Neoplasias de Cabeça e Pescoço/cirurgia , Humanos , Processamento de Imagem Assistida por Computador/métodos , Linfonodos/patologia , Metástase Linfática/patologia , Masculino , Neoplasias Mandibulares/diagnóstico por imagem , Neoplasias Mandibulares/patologia , Neoplasias Mandibulares/cirurgia , Pessoa de Meia-Idade , Pescoço , Radiografia Panorâmica/métodos , Resultado do Tratamento
12.
Rev. esp. cir. oral maxilofac ; 42(3): 132-135, jul.-sept. 2020. ilus
Artigo em Espanhol | IBECS | ID: ibc-196629

RESUMO

El tumor maligno de la vaina nerviosa periférica (TMVNP) es un tumor mesenquimal raro que surge de las células de la vaina del nervio periférico. Tiene un comportamiento agresivo. Generalmente se presenta en extremidades y tronco, siendo su presencia en cabeza y cuello muy poco frecuente. Reportamos un caso raro de TMVNP del nervio dentario inferior en su trayecto intraóseo mandibular, no asociado a neurofibromatosis


Malignant peripheral nerve sheath tumour (MPNST) is a rare mesenchymal tumor that arises from peripheral nerve sheath cells. It has aggressive behavior. It usually occurs in extremities and trunk, being its presence in head and neck very infrequent. We report a rare case of TMVNP of the inferior dental nerve in its mandibular intraosseous pathway, not associated with neurofibromatosis


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias da Bainha Neural/patologia , Neoplasias Mandibulares/patologia , Neurilemoma/patologia , Imuno-Histoquímica/métodos , Radiografia Panorâmica/métodos , Neoplasias da Bainha Neural/cirurgia , Neoplasias Mandibulares/cirurgia , Neurilemoma/cirurgia
13.
Pan Afr Med J ; 36: 111, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32821322

RESUMO

Introduction: primary maxillofacial tumors are uncommon in pediatric patients. When they do occur, the tissue damage caused directly alters facial growth, development as well as psycho-social evolution. This study was carried out to determine the pattern, sociodemographic characteristics and histologic peculiarities of paediatric jaw tumors in our environment. Methods: a retrospective hospital-based study where the case notes of children below the age of 14 years who presented with jaw tumors and tumor-like lesions from January 2014 to December 2018 were studied. Results: eighty-two patients were studied; patients aged 10-14 years had the highest representation. Mean time of presentation was 8 months with jaw swelling being the commonest presentation (84.1%). Majority of the fathers were in their 4th decade of life while most of the mothers were in their third decade of life and both parents possessed primary school certificate as their highest level of educational attainment. Fathers were mostly traders, while mothers were mostly full-time housewives. The maxilla and mandible were most commonly affected with the left side showing higher preponderance. Burkitt lymphoma (19 (23.2%)) and adenomatoid odontogenic tumor (14 (17.1%)) were the commonest lesions. When the tumor involved both the maxilla and the mandible, the tumor was most likely malignant. Conclusion: in our center, paediatric jaw tumors are commonest in male children with the 10-14 years´ age group most commonly affected. Burkitt lymphoma and adenomatoid odontogenic tumors were the commonest tumors. Early presentation must be encouraged since these tumors if presented early can be successfully treated.


Assuntos
Ameloblastoma/epidemiologia , Linfoma de Burkitt/epidemiologia , Neoplasias Mandibulares/epidemiologia , Neoplasias Maxilares/epidemiologia , Adolescente , Distribuição por Idade , Ameloblastoma/patologia , Linfoma de Burkitt/patologia , Criança , Pré-Escolar , Escolaridade , Pai/estatística & dados numéricos , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Neoplasias Mandibulares/patologia , Neoplasias Maxilares/patologia , Mães/estatística & dados numéricos , Estudos Retrospectivos , Distribuição por Sexo , Centros de Atenção Terciária
14.
J Cancer Res Ther ; 16(3): 647-652, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32719283

RESUMO

The leiomyoma is a benign smooth-muscle neoplasm commonly found in the female genital tract, gastrointestinal tract, or skin. Leiomyomas of the oral cavity are unusual. Oral leiomyomas are uncommon due to the paucity of the smooth muscle in the mouth (except in blood vessels) and thus the involvement of jaw bones is extremely rare. Leiomyomas have been classified as solid angiomyoma, angioleiomyoma (vascular leiomyoma), and epithelioid variants. Angioleiomyomas are benign mesenchymal tumors derived from smooth muscle, which rarely occur in the oral cavity. Malignant transformation probably does not occur but careful histopathologic examination is still necessary to differentiate these benign lesions from their malignant counterparts due to different prognosis. Although uncommon in the maxilla and mandible, they should be included in the differential diagnosis of radiolucent lesions of jaw bones. An extensive search of literature was carried out on the Medline-PubMed and Google Scholar database using the keywords such as leiomyoma, angioleiomyoma, jaw bones, maxilla, mandible, intra-osseous to thoroughly search and collect all the reported cases of intraosseous leiomyoma (but our search was not limited to these terms only). To the best of our knowledge, only 23 cases of intraosseous leiomyomas have been reported so far in the jaw bones, among which only 8 belonged to angioleiomyomas. Herein, we report the 9th case of intraosseous angioleiomyoma, one of the variants of leiomyoma and overall 24th intraosseous leiomyoma in a 6-year-old female child, together with conventional histopathologic and immunohistochemical findings.


Assuntos
Angiomioma/patologia , Neoplasias Mandibulares/patologia , Doenças Raras/patologia , Actinas/metabolismo , Angiomioma/metabolismo , Angiomioma/cirurgia , Antígenos CD34/metabolismo , Biomarcadores Tumorais/metabolismo , Criança , Feminino , Humanos , Neoplasias Mandibulares/metabolismo , Neoplasias Mandibulares/cirurgia , Músculo Liso/metabolismo , Músculo Liso/patologia , Doenças Raras/metabolismo , Doenças Raras/cirurgia
15.
J Cancer Res Ther ; 16(3): 683-685, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32719292

RESUMO

Squamous cell carcinomas of the oral cavity are quite common, but primary intraosseous squamous cell carcinomas (PIOSCCs) are rare. Their origin from lining of different odontogenic cysts has been documented. More than 50% of such cases have been reported to occur in periapical inflammatory cysts, and less than 10 cases are reported to arise from odontogenic keratocyst (OKC). One such rare case of a PIOSCC, which presented as an OKC initially, is being reported.


Assuntos
Carcinoma de Células Escamosas/patologia , Neoplasias Mandibulares/patologia , Cistos Odontogênicos/patologia , Tumores Odontogênicos/patologia , Adulto , Carcinoma de Células Escamosas/cirurgia , Humanos , Masculino , Neoplasias Mandibulares/cirurgia , Gradação de Tumores , Cistos Odontogênicos/cirurgia , Tumores Odontogênicos/cirurgia
16.
J Egypt Natl Canc Inst ; 32(1): 1, 2020 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-32372370

RESUMO

BACKGROUND: Ameloblastoma is the commonest odontogenic tumour of epithelial origin with a high incidence for developing local recurrence. We present a patient who developed local recurrence in both soft tissue and bone graft 17 years after the initial presentation. CASE PRESENTATION: A 75-year-old female with a previous history of right hemimandibulectomy and rib reconstruction for ameloblastoma in 1999 presented to our centre with a large cystic mouth floor swelling, biopsy from which revealed recurrent ameloblastoma. The patient underwent excision of the recurrent mass en bloc with the cystic swelling through oral and cervical approaches. The patient was discharged after 5 days with an uneventful postoperative course and with a free 2-year follow-up from further recurrence. CONCLUSION: Ameloblastoma is a locally aggressive tumour for which wide local excision with adequate margins is the best management approach. Recurrence of ameloblastoma even after adequate resection is not uncommon, and its management is considered a surgical challenge. A very long time may pass between the initial presentation and the development of recurrence.


Assuntos
Ameloblastoma/patologia , Autoenxertos/patologia , Mandíbula/patologia , Neoplasias Mandibulares/patologia , Recidiva Local de Neoplasia/diagnóstico , Idoso , Ameloblastoma/diagnóstico , Ameloblastoma/cirurgia , Autoenxertos/diagnóstico por imagem , Transplante Ósseo/métodos , Feminino , Humanos , Mandíbula/diagnóstico por imagem , Mandíbula/cirurgia , Neoplasias Mandibulares/diagnóstico , Neoplasias Mandibulares/cirurgia , Osteotomia Mandibular , Esvaziamento Cervical , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/cirurgia , Costelas/transplante , Tomografia Computadorizada por Raios X , Resultado do Tratamento
17.
Indian J Pathol Microbiol ; 63(2): 276-278, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32317532

RESUMO

Neurofibroma (NF) is a benign tumor derived from the peripheral nerve sheath. Neurofibromas may present either as solitary lesions or as part of the generalized syndrome of neurofibromatosis or von Recklinghausen's disease of the skin. The intraosseous variant of NF is very rare. We report a case of a 32-year-old female who was diagnosed with a solitary intraosseous neurofibroma of the mandible. The present case is rare with respect to its unique histopathologic feature.


Assuntos
Mandíbula/patologia , Neoplasias Mandibulares/diagnóstico , Neurofibroma/diagnóstico , Adulto , Biópsia , Feminino , Histologia , Humanos , Neoplasias Mandibulares/patologia , Neurofibroma/patologia , Tomografia Computadorizada por Raios X
19.
Niger J Clin Pract ; 23(3): 291-297, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32134025

RESUMO

Aims: To evaluate the presence of dentofacial asymmetry in patients with odontoma by panoramic radiography. Methods: Panoramic images with odontoma were selected among all panoramic radiographs (3058 patients). Maxillary odontoma was detected in 27 patients while mandibular odontoma was detected in 25 patients. In addition, 30 patients with similar age and gender characteristics were selected as the control group. Skeletal angular, skeletal linear and dental measurements were performed on panoramic radiographs. The odontoma region and the opposite side of the odontoma of the individuals were examined. The dentofacial asymmetry of the odontoma groups was compared with the control group. Paired t-test was used to determine dentofacial asymmetry on the right and left side of the patients with odontoma. The ANOVA test was used for testing the differences among groups. Results: As a result of study, no significant difference was found between the region of the odontoma and the symmetrical region in the maxilla and mandibula (P > 0.05). In the control group, a statistically significant difference was found in the angle between the mandibular canal and the mental foramen, lower incisor size, PFH/CutCat(°), and Co-Mc-Me(°) measurements (P < 0.05). In the maxillary and mandibular odontoma groups, a statistically significant difference was found in the angle between the mandibular canal and the menton, CH (mm), RH (mm), and CrH (mm) in the comparison of the odontoma and the control group (P < 0.05). Conclusions: No difference was found between the right and left sides of the jaws related with the asymmetry of the maxilla and mandible.


Assuntos
Deformidades Dentofaciais/diagnóstico por imagem , Assimetria Facial/diagnóstico por imagem , Mandíbula/diagnóstico por imagem , Neoplasias Mandibulares/complicações , Maxila/diagnóstico por imagem , Neoplasias Maxilares/complicações , Odontoma/complicações , Radiografia Panorâmica/métodos , Adolescente , Adulto , Cefalometria/métodos , Feminino , Humanos , Incisivo , Masculino , Neoplasias Mandibulares/patologia , Neoplasias Maxilares/patologia , Odontoma/patologia , Adulto Jovem
20.
Int. j. odontostomatol. (Print) ; 14(1): 117-123, mar. 2020. tab, graf
Artigo em Espanhol | LILACS | ID: biblio-1056510

RESUMO

RESUMEN: El Leiomioma es una neoplasia benigna originada en el tejido muscular liso por lo que puede manifestarse en cualquier región del cuerpo humano que contenga músculo liso, siendo el sitio más común el útero, la piel y en el tracto gastrointestinal. La escasa cantidad de tejido muscular liso en boca hace que su manifestación oral sea infrecuente, representando solo 0.06 % del total de este tipo de tumores. Los sitios más afectados suelen ser los labios, las mejillas, el paladar, la lengua y encías. Histológicamente se distinguen tres tipos: el Leiomioma Sólido, Angioleiomioma (Vascular) y Leiomioma Epitelioide (Leiomioblastoma). El origen de esta neoplasia en boca suele ser la túnica media de los vasos sanguíneos. El Leiomioma intraóseo suele ser aún menos frecuente, y con un diagnóstico diferencial complejo, con histopatología que en varias ocasiones no suele ser fácil de clasificar. Si bien es definida como un tumor benigno, su manifestación intraósea puede llegar a ser localmente agresiva y con un diagnóstico controversial, debiendo abordarse muchas veces como una neoplasia maligna. El objetivo de este artículo es presentar una revisión de la literatura de esta variante intraósea de Leiomioma situada en mandíbula, sus consideraciones clínicas y un algoritmo de tratamiento.


ABSTRACT: Leiomyoma is a benign neoplasm, the origin is the smooth muscle tissue that can be found in any area of the human body, which contains smooth muscle tissue. The most common regions it can be located, are the uterus, the skin and the gastrointestinal tract. The low quantity of muscle tissue in the mouth leads to infrequent oral manifestation, representing only 0.06 % of these tumors. The most affected regions are the lips, cheeks, palate, tongue and gums. The Histologic classification is: Solid Leiomyoma, Angioleiomyoma (vascular) and Epithelioid Leiomyoma (Leiomyoblastoma). The origin of this tumor in the mouth is the tunica media of the blood vessels. Nevertheless, and in spite of being defined as a benign tumor, it can be extremely aggressive, be subject to controversial diagnosis, and must often be treated as a malign neoplasm. The Intraosseous Leiomyoma is infrequent and presents a complicated differential diagnosis, with a histopathology that many times cannot be easily classified. The aim of this article is to present a review of intraosseous variant Leiomyoma in the mandible, the clinicians´ considerations and a treatment algorithm.


Assuntos
Humanos , Neoplasias Mandibulares/diagnóstico por imagem , Leiomioma Epitelioide/diagnóstico , Angiomioma , Leiomioma/diagnóstico , Leiomioma/patologia , Boca , Algoritmos , Radiografia Panorâmica , Neoplasias Mandibulares/cirurgia , Neoplasias Mandibulares/patologia , Tomografia Computadorizada por Raios X , Leiomioma/cirurgia
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