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1.
Medicine (Baltimore) ; 100(35): e27136, 2021 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-34477164

RESUMO

RATIONALE: Small cell neuroendocrine carcinoma of the nasal cavity and paranasal sinuses is a rare but aggressive neoplasm with a poor prognosis and a strong propensity for regional recurrence and distant metastasis. Diagnosis is challenging and relies on immunohistochemical study. Treatment includes surgical resection, radiation therapy, chemotherapy, or a combination of these modalities. However, the optimal therapeutic strategy is still controversial. Due to its rarity, the complexity of the histological diagnosis, and the variety of the treatment regimens, we presented a case of primary small cell neuroendocrine carcinoma in the nasal cavity with description of the clinical manifestation, pathology features, and our treatment regimen. PATIENT CONCERNS: An 82-year-old female patient with hypertension presented with right epistaxis on and off with nasal obstruction for several days. DIAGNOSIS: An exophytic mass over the posterior end of the right inferior turbinate was found on nasopharyngoscope. Biopsy was done and the pathology confirmed small cell carcinoma, strongly positive for cytokeratin (AE1/AE3) and insulinoma-associated protein 1 (INSM-1), scatteredly positive for chromogranin A, synaptophysin and CD56. The final diagnosis was small cell neuroendocrine carcinoma of right nasal cavity, pT1N0M0, stage I. INTERVENTIONS: The patient underwent wide excision of right intra-nasal tumor and post-operative radiotherapy with a dose of 6600 cGy in 33 fractions. OUTCOMES: No local recurrence or distant metastasis was noted during the 12 months of follow-up. LESSONS: Multimodality treatment remains the most common therapeutic strategy, although no proven algorithm has been established due to the rarity of this disease. Further investigation is needed for providing evidence to standardize the treatment protocol.


Assuntos
Carcinoma Neuroendócrino/patologia , Cavidade Nasal/patologia , Neoplasias Nasais/patologia , Idoso de 80 Anos ou mais , Carcinoma Neuroendócrino/radioterapia , Carcinoma Neuroendócrino/cirurgia , Feminino , Humanos , Neoplasias Nasais/radioterapia , Neoplasias Nasais/cirurgia
2.
Artigo em Chinês | MEDLINE | ID: mdl-34344098

RESUMO

Objective: To summarize the preliminary experience in the treatment of esthesioneuroblastoma (ENB) and to explore the effect of age, chemotherapy, modified Kadish stage and pathological grade on the prognosis of ENB. Methods: The clinical data of 87 ENB patients from the First Affiliated Hospital of Sun Yat-sen University and Sun Yat-sen University Cancer Center between June 2002 and November 2017 were retrospectively analyzed. The modified Kadish stage was used to evaluate the extent of the lesions, and the Hyams grading system was used for pathological grading. The patients were followed up regularly to evaluate the recurrence and metastasis of the tumor. Cox proportional hazard model was used for univariate and multivariate analyses. Prognostic factors with P<0.05 in univariate analysis were included in multivariate analysis. After controlling the confounding factors, the model coefficients were used to calculate the hazard ratio (HR) and 95% confidence interval (CI). Results: The median follow-up time of ENB patients was 29 months, and the 5-year overall survival rate was 39.3%. In univariate analysis, age, chemotherapy, modified Kadish stage and pathology grade were independent predictors of overall survival, while gender, radiotherapy and surgery were not prognostic factors. Multivariate analysis showed that modified Kadish stage and pathology grade were independent predictors of overall survival rate after excluding confounding factors. Conclusions: Age, chemotherapy, modified Kadish stage and pathological grade are taking important role in the overall survival rate of patients with ENB. Modified Kadish stage and pathological grade are independent predictors of overall survival rate.


Assuntos
Estesioneuroblastoma Olfatório , Neoplasias Nasais , Estesioneuroblastoma Olfatório/patologia , Estesioneuroblastoma Olfatório/terapia , Humanos , Cavidade Nasal/patologia , Recidiva Local de Neoplasia , Estadiamento de Neoplasias , Neoplasias Nasais/patologia , Neoplasias Nasais/terapia , Prognóstico , Estudos Retrospectivos
3.
J Laryngol Otol ; 135(10): 937-939, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34446116

RESUMO

BACKGROUND: Total rhinectomy is an invasive procedure that significantly impairs the intranasal turbulence, humidification and heating of inspired air. The use of uvulopalatopharyngoplasty for the treatment of sleep-disordered breathing disorders such as primary snoring and obstructive sleep apnoea has diminished over the past years because of the emergence of less invasive procedures and alternative therapeutic options. This clinical record presents the treatment of a long-term side effect of total rhinectomy using uvulopalatopharyngoplasty. CASE REPORT: In 1997, a 62-year-old male underwent total rhinectomy for a nasal schwannoma, followed by rehabilitation with a nasal prosthesis. Twenty-one years later, he presented with severe complaints of nasal blockage and breathing difficulties during both daytime and night-time. Clinical examination revealed no major anomalies besides significant velopharyngeal narrowing. Thus, in 2019, uvulopalatopharyngoplasty was performed to re-establish velopharyngeal patency. Hereafter, the symptoms of nasal blockage disappeared, resulting in an improved quality of life. CONCLUSION: Uvulopalatopharyngoplasty may prove useful to treat selected patients with daytime breathing difficulties due to velopharyngeal narrowing.


Assuntos
Obstrução Nasal/cirurgia , Procedimentos Cirúrgicos Nasais/efeitos adversos , Neurilemoma/cirurgia , Palato Mole/cirurgia , Faringe/cirurgia , Úvula/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Obstrução Nasal/etiologia , Neurilemoma/diagnóstico , Neurilemoma/reabilitação , Neoplasias Nasais/patologia , Palato Mole/patologia , Faringe/patologia , Próteses e Implantes/efeitos adversos , Qualidade de Vida , Procedimentos Cirúrgicos Reconstrutivos/métodos , Aderências Teciduais/cirurgia , Resultado do Tratamento , Úvula/patologia
4.
Sci Rep ; 11(1): 17100, 2021 08 24.
Artigo em Inglês | MEDLINE | ID: mdl-34429452

RESUMO

To better understand the pathogenesis of nasal polyps (NPs) and sinonasal inverted papillomas (SIPs), we aimed to establish cell lines from fresh tissues of NPs and SIPs and characterize them. Primary cell cultures were obtained from two NP tissues (NP2 and NP3) and one SIP tissue (IP4). All the cells were polygonal in shape, expressed cytokeratin 14, and had normal diploid chromosome status. HPV58 DNA was detected in NP3. To obtain immortal primary cells, NP2 and IP4 cells were transduced with a combination of mutant CDK4, cyclinD1 and TERT. These cells were thereafter named NP2/K4DT and IP4/K4DT, respectively. HPV58-positive NP3 cells were transduced with TERT alone, the resulting cells named NP3/T. Phenotypic and genotypic identity of original tissues and derived cells was investigated. All the cell cultures with transgenes were confirmed to be derived from their parental cells and primary tumor tissues by analysis of short tandem repeats (STR) and maintained in vitro growth, genetic profiles and gene expression characteristics of the primary cells. These virtually immortalized cells, as well as the primary cells, have potential as in vitro models for studying the pathogenesis of NPs and SIPs and for preclinical study to develop new therapeutic agents.


Assuntos
Técnicas de Cultura de Células/métodos , Pólipos Nasais/genética , Neoplasias Nasais/genética , Papiloma Invertido/genética , Adolescente , Idoso , Linhagem Celular Tumoral , Proliferação de Células , Células Cultivadas , Criança , Ciclina D1/genética , Ciclina D1/metabolismo , Quinase 4 Dependente de Ciclina/genética , Quinase 4 Dependente de Ciclina/metabolismo , Humanos , Masculino , Repetições de Microssatélites , Pólipos Nasais/patologia , Neoplasias Nasais/patologia , Papiloma Invertido/patologia , Telomerase/genética , Telomerase/metabolismo , Transdução Genética/métodos
5.
J Surg Oncol ; 124(5): 731-739, 2021 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-34236707

RESUMO

OBJECTIVES: Sinonasal and skull base tumors are rare, making it difficult to identify trends in surgical outcome. This study examines complications in a large cohort of patients undergoing surgery for sinonasal malignancy. METHODS: Following IRB approval, an institutional database was reviewed to identify patients who underwent surgery for sinonasal or skull base malignancies from 1973 to 2016 at our institution. Charlson comorbidity index score and Clavien-Dindo grade were calculated. The main study endpoint was subgroup analysis of Clavien-Dindo Grade 0, Grades 1-2, and Grades 3-5 complications. An ordinal logistic regression model was constructed to assess the association between comorbidities, demographics, tumor characteristics, and surgical complications. RESULTS: In total, 448 patients met inclusion criteria. Perioperative mortality rate at 30 days was 1.6% (n = 7). The rate of severe complications (Clavien-Dindo 3 or higher) was 13.6% (n = 61). Multivariate analysis using an ordinal logistic regression model showed no association between Charlson comorbidity index score and Clavien-Dindo grade of postoperative complication. Advanced T-stage was significantly associated with complications (p = 0.0014; odds ratio: 3.442 [95% confidence interval: 1.615, 7.338]). CONCLUSION: Surgery for sinonasal and skull base tumors is safe with a low mortality rate. Advanced T-stage is associated with postoperative complications. These findings have implications for preoperative risk stratification. Key Points Surgery for sinonasal malignancy is safe with a 30 mortality of 1.6% and rate of severe complications of 12.8%. There is no association between patient comorbidity and post operative complication. On multivariate analysis, only advanced T stage was associated with increased rate of surgical complication.


Assuntos
Neoplasias Nasais/cirurgia , Neoplasias dos Seios Paranasais/cirurgia , Complicações Pós-Operatórias/patologia , Neoplasias da Base do Crânio/cirurgia , Procedimentos Cirúrgicos Operatórios/efeitos adversos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Nasais/patologia , Neoplasias dos Seios Paranasais/patologia , Complicações Pós-Operatórias/etiologia , Prognóstico , Estudos Prospectivos , Estudos Retrospectivos , Neoplasias da Base do Crânio/patologia , Taxa de Sobrevida , Adulto Jovem
6.
Top Magn Reson Imaging ; 30(3): 139-149, 2021 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-34096897

RESUMO

ABSTRACT: Sinonasal cavity is an important subsite in head and neck tumors. There are a myriad of malignancies that present within this area. Adequate staging for treatment planning requires multimodality evaluation. Magnetic resonance imaging (MRI) forms an important component in the evaluation of sinonasal tumors. We sought to review the most common sinonasal tumors, including sinonasal anatomy, clinical features, and common imaging features. A literature review was performed to evaluate common sinonasal tumors. Owing to the different tissue types within the sinonasal cavity, there are multiple different tumor pathologies within the sinonasal compartment. Most present in adults although some present in the young. Many of these tumor types have imaging overlaps, although some have a characteristic appearance. MRI can aid in soft tissue delineation, evaluation of multicompartmental extension, intracranial spread, and perineural spread. Sinonasal tumors are a heterogeneous group for which soft tissue delineation via MRI forms an important role in ensuring adequate treatment planning to improve outcomes, decreasing morbidity, and improve functional outcomes.


Assuntos
Imageamento por Ressonância Magnética/métodos , Neoplasias Nasais/diagnóstico por imagem , Humanos , Processamento de Imagem Assistida por Computador , Neoplasias Nasais/patologia , Neoplasias Nasais/terapia
7.
Laryngoscope ; 131(12): 2724-2728, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34160868

RESUMO

OBJECTIVES/HYPOTHESIS: To analyze the clinical features, classification, and treatment of adult nasopharyngolaryngeal hemangioma (ANPLH). STUDY DESIGN: Retrospective study. METHODS: From February 2009 to May 2020, 101 patients with ANPLH were reviewed and analyzed. RESULTS: Symptoms of ANPLH were frequently displayed as abnormal pharyngeal sensation and functional defection. According to lesion location, ANPLH was divided into five categories including nasopharyngeal, oropharyngeal, hypopharyngeal, laryngeal, and mixed types. The mixed type constitutes the highest portion, and the nasopharyngeal type is the least in our cohort. Most lesions could resect through natural cavity under endoscopy. Patients with mixed lesions had a higher rate of postoperative recurrence and planned multiple surgeries. Acceptable but not severe intraoperative and postoperative complications occurred in our patient cohort. CONCLUSIONS: Patients with ANPLH are always symptomatic and even functional defective, which can be classified into five categories based on lesion location. For these patients, endoscopic surgery through natural cavity is recommended to remove lesions with fewer complications and favorable clinical outcomes. LEVEL OF EVIDENCE: 4 Laryngoscope, 131:2724-2728, 2021.


Assuntos
Hemangioma/diagnóstico , Neoplasias Laríngeas/diagnóstico , Cirurgia Endoscópica por Orifício Natural , Recidiva Local de Neoplasia/epidemiologia , Neoplasias Nasais/diagnóstico , Neoplasias Faríngeas/diagnóstico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Hemangioma/epidemiologia , Hemangioma/patologia , Hemangioma/cirurgia , Humanos , Neoplasias Laríngeas/epidemiologia , Neoplasias Laríngeas/patologia , Neoplasias Laríngeas/cirurgia , Masculino , Pessoa de Meia-Idade , Neoplasias Nasais/epidemiologia , Neoplasias Nasais/patologia , Neoplasias Nasais/cirurgia , Neoplasias Faríngeas/epidemiologia , Neoplasias Faríngeas/patologia , Neoplasias Faríngeas/cirurgia , Estudos Retrospectivos , Adulto Jovem
8.
Anticancer Res ; 41(5): 2495-2499, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33952477

RESUMO

BACKGROUND/AIM: Sino-nasal cancer is rare and often diagnosed at advanced stages. Some patients cannot receive curative treatment and are treated with palliative irradiation. We aimed to identify prognostic factors for survival to facilitate treatment personalization for this group. PATIENTS AND METHODS: Twelve patients treated with palliative radiotherapy for locally advanced sino-nasal cancer were retrospectively analyzed for survival. Ten characteristics were evaluated including age, gender, Karnofsky performance score (KPS), pre-radiotherapy hemoglobin, tumor site, lymph node involvement, histology, equivalent dose in 2 Gy-fractions, completion of radiotherapy and concurrent chemotherapy. RESULTS: On univariate analysis, KPS ≥70 (p<0.001) and completion of radiotherapy (p<0.001) were significantly associated with better survival. Chemotherapy showed a trend (p=0.097). In the multivariate analysis, KPS ≥70 was significant (p=0.025), and completion of radiotherapy showed a trend (p=0.080). CONCLUSION: KPS is an independent predictor of survival for palliative irradiation of sino-nasal cancer. Patients require close monitoring and care for side effects, since completion of radiotherapy is important for survival.


Assuntos
Neoplasias Nasais/radioterapia , Cuidados Paliativos/métodos , Radioterapia/métodos , Idoso , Idoso de 80 Anos ou mais , Intervalo Livre de Doença , Feminino , Humanos , Estimativa de Kaplan-Meier , Masculino , Neoplasias Nasais/patologia , Teste de Desfecho Sinonasal
10.
Laryngoscope ; 131(10): E2640-E2642, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-33811658

RESUMO

Inverted papilloma is a rare sinonasal neoplasm. It can be locally invasive and potentially degenerate to a malignant tumor. We present a case report of a 36-year-old woman who was treated for nasal inverted papilloma for over 10 years and presented bilateral temporal bone, and pulmonary involvement. Several procedures were performed to completely remove the tumor. Even without evidence of malignant degeneration, the patient continued battling tumor recurrences. To the best of our knowledge, this report presents the first case of a multicentric inverted papilloma with nasal, bilateral temporal bone, and pulmonary metachronous localization. Laryngoscope, 131:E2640-E2642, 2021.


Assuntos
Neoplasias Pulmonares/secundário , Neoplasias Nasais/patologia , Papiloma Invertido/patologia , Osso Temporal/patologia , Adulto , Terapia Combinada , Feminino , Humanos , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/terapia , Invasividade Neoplásica , Neoplasias Nasais/diagnóstico por imagem , Neoplasias Nasais/terapia , Papiloma Invertido/diagnóstico por imagem , Papiloma Invertido/terapia , Osso Temporal/diagnóstico por imagem
11.
Open Vet J ; 11(1): 1-5, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33898276

RESUMO

Background: Primary neoplasms of the nasal cavity and sinuses are uncommon in domestic animals, most of which are of epithelial origin, being adenocarcinoma the most common tumor diagnosed in this region. Some malignant nasal cavity neoplasms may invade the brain causing clinical neurological signs, as well as purulent nasal secretion and epistaxis. Case Description: A case of neoplasm is reported in a 14-year-old pincher presenting dyspnea, epistaxis, and neurological alterations. Necropsy revealed the presence of a mass in the oral cavity vestibule, and another in the whole nasal cavity with invasion of the cribiform plate, meninges and brain. Squamous cells carcinoma was diagnosed in the oral cavity and transitional carcinoma in the nasal cavity. The immunohistochemistry confirmed that the brain infiltration was of the same origin as the nasal cavity neoplasm. Conclusion: The present report describes a rare case of transitional carcinoma of the nasal cavity as well as the frontal and ethmoidal sinuses with brain invasion, confirmed by immunohistochemistry. It is extremely important for veterinarians to include neoplasms in their differential diagnoses, when these animals show chronic respiratory signs and neurological alterations that do not improve with appropriate treatment, always associating with complementary exams, for correct diagnosis establishment and prognosis formulation.


Assuntos
Neoplasias Encefálicas/veterinária , Carcinoma de Células Escamosas/veterinária , Carcinoma de Células de Transição/veterinária , Doenças do Cão/patologia , Neoplasias Bucais/veterinária , Neoplasias Nasais/veterinária , Animais , Neoplasias Encefálicas/secundário , Carcinoma de Células Escamosas/patologia , Carcinoma de Células de Transição/diagnóstico , Carcinoma de Células de Transição/patologia , Doenças do Cão/diagnóstico , Cães , Seio Etmoidal/patologia , Meninges/patologia , Neoplasias Bucais/patologia , Cavidade Nasal/patologia , Metástase Neoplásica , Neoplasias Nasais/diagnóstico , Neoplasias Nasais/patologia
12.
Acta Otolaryngol ; 141(5): 513-518, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-33794734

RESUMO

BACKGROUND: Storz Professional Image Enhancement System (SPIES) endoscopy is an optical method to enhance the visualization of microvasculature on the mucosal surface and characterize epithelial changes. OBJECTIVE: In this study, we aimed to detect sinonasal inverted papilloma (SIP) in the microvasculature and/or mucosa using SPIES endoscopy. MATERIALS AND METHODS: A total of 115 subjects, including 80 patients with SIPs or nasal polyps (NPs) and 35 healthy controls were investigated using white light endoscopy (WLE) and SPIES endoscopy. All lesions were diagnosed by histopathological examination. We used Kappa index (κ) to evaluate the agreement of WLE and SPIES endoscopy with the histopathology. The sensitivity, specificity, positive predictive value, and negative predictive value were independently determined. RESULTS: NPs were histologically confirmed in 44 subjects (55%, 44/80), identified by WLE in 41 subjects (51.3%, 41/80), and identified by SPIES endoscopy in 43 subjects (53.8%, 43/80). SIPs were histologically confirmed in 36 cases (45%, 36/80), defined by WLE in 24 cases (30%, 24/80), and identified by SPIES endoscopy in 33 cases (41.3%, 33/80). Among 36 SIP patients, 33 cases (91.67%, 33/36) had a small lobular sign. The diagnosis of SIP by SPIES endoscopy was in excellent agreement with histopathological diagnosis (κ = 0.873), while the diagnosis of SIP by WLE was in moderate agreement (κ = 0.563). CONCLUSIONS AND SIGNIFICANCE: SPIES endoscopy is a rapid and noninvasive live-imaging technique with a unique contrast to examine sinonasal mucosa, submucosa and microvasculature. Our study suggested SPIES endoscopy could detect SIP, and the small lobular sign could be a sensitive predictor of SIP diagnosis.


Assuntos
Endoscopia/métodos , Aumento da Imagem , Neoplasias Nasais/diagnóstico por imagem , Papiloma Invertido/diagnóstico por imagem , Neoplasias dos Seios Paranasais/diagnóstico por imagem , Adolescente , Adulto , Idoso , Estudos de Casos e Controles , Diagnóstico Diferencial , Endoscopia/instrumentação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pólipos Nasais/diagnóstico por imagem , Pólipos Nasais/patologia , Neoplasias Nasais/patologia , Papiloma Invertido/patologia , Neoplasias dos Seios Paranasais/patologia , Projetos Piloto , Sensibilidade e Especificidade
13.
Artigo em Chinês | MEDLINE | ID: mdl-33794606

RESUMO

Objective:To explore the therapeutic effect and prognostic risk factors of olfactory neuroblastoma. Methods:Retrospective analysis of clinical data of 31 patients with olfactory neuroblastoma. The Kaplan-Meier method was used for survival analysis to calculate the overall survival rate and progress-free survival rate. Results:All 31 patients underwent surgical treatment and 7 patients died, of which 4 patients died of simple intracranial invasion and 3 patients died of concurrent distant metastasis (lung and spinal cord). The average death time was 40.7 (20-57) months. Statistical analysis showed that craniocerebral invasion (P=0.035), age ≥60 years (P=0.042), and Ki-67≥20%(P=0.018) were closely related to the poor prognosis. It is speculated that the increase of T staging and modified Kadish staging are also predictors of poor prognosis. The 1-year and 5-year overall survival rates were 100.0% and 72.5%, and the 1-year and 5-year progress-free survival rates were 87.8% and 33.6% after first surgery. Conclusion:Surgery combined with radiotherapy and chemotherapy are the main treatments for olfactory neuroblastoma, but postoperative recurrence and metastasis are common. About 22.6% of the patients died during the follow-up. Advanced age, intracranial invasion and Ki-67≥20% are closely related to poor prognosis. The tumor was completely removed by the initial surgery and restricted in nasal cavity and sinuses are the key factors for a good prognosis.


Assuntos
Estesioneuroblastoma Olfatório , Neoplasias Nasais , Estesioneuroblastoma Olfatório/patologia , Humanos , Pessoa de Meia-Idade , Cavidade Nasal/patologia , Recidiva Local de Neoplasia , Estadiamento de Neoplasias , Neoplasias Nasais/patologia , Prognóstico , Estudos Retrospectivos , Taxa de Sobrevida
14.
Artigo em Chinês | MEDLINE | ID: mdl-33794633

RESUMO

Objective:To investigate the clinical characteristics and prognostic factors of esthesioneuroblastoma. Methods:The clinical data of 31 patients with esthesioneuroblastoma were retrospectively studied. Results:The average time from first onset to diagnosis in 31 patients was 7.84 months, among which 3 patients(9.68%) had cervical lymph node metastasis at the first visit. By the end of follow-up, there were 25 coexisting cases and 6 deaths. The mean recurrence time of 6 patients was 10.6 months. There were 6 patients with distant metastasis, including 4 patients with cervical lymph node metastasis, 1 patient with liver metastasis and 1 patient with bone metastasis. Modified Kadish stage, different treatment methods, recurrence, first diagnosis of cervical lymph node metastasis, and distant metastasis were all factors affecting the prognosis of the patients. Conclusion:The incidence of esthesioneuroblastoma is low and the comprehensive treatment of surgery combined with radiotherapy is the optimal treatment plan. Patients with low Kadish staging, surgical combined with radiotherapy, no recurrence, no initial cervical lymph node metastasis, and no distant metastasis have a better prognosis.


Assuntos
Estesioneuroblastoma Olfatório , Neoplasias Nasais , Estesioneuroblastoma Olfatório/diagnóstico , Estesioneuroblastoma Olfatório/patologia , Estesioneuroblastoma Olfatório/terapia , Humanos , Linfonodos/patologia , Cavidade Nasal/patologia , Recidiva Local de Neoplasia/patologia , Estadiamento de Neoplasias , Neoplasias Nasais/diagnóstico , Neoplasias Nasais/patologia , Neoplasias Nasais/terapia , Prognóstico , Estudos Retrospectivos
15.
Rev. esp. patol ; 54(1): 59-64, ene.-mar. 2021. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-202491

RESUMO

El carcinoma epidermoide sarcomatoide es una entidad rara en la fosa nasal. Presentamos el caso de un varón de 50 años con una masa polipoide en la cavidad nasal izquierda. En el estudio anatomopatológico, se observa una histología bifásica de nidos escamosos no queratinizantes y un estroma sarcomatoide con positividad para AE1-AE3. El paciente presentó metástasis cervicales ipsilaterales, tratándose con vaciamiento cervical, radioterapia y cisplatino adyuvante. Dos años después se encuentra libre de enfermedad


Spindle cell carcinoma of the nasal cavity is a rare variant of squamous cell carcinoma. We report a case of a 50 year-old male presenting with a polypoid mass in the left nasal cavity. Histologically, the tumor was biphasic, composed of non-keratinizing squamous nests and a sarcomatoid stroma with positivity for CKAE1-AE3. Metastatic ipsilateral lymph nodes were present and the patient underwent radical neck dissection, followed by adjuvant radiotherapy and cisplatin. Two years after diagnosis the patient is free of disease


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Carcinossarcoma/patologia , Neoplasias Nasais/patologia , Cavidade Nasal/patologia , Metástase Neoplásica/patologia , Carcinossarcoma/diagnóstico , Metástase Neoplásica/tratamento farmacológico , Metástase Neoplásica/radioterapia , Intervalo Livre de Doença , Imuno-Histoquímica
16.
Clin Nucl Med ; 46(7): e378-e380, 2021 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-33782294

RESUMO

ABSTRACT: Esthesioneuroblastoma is a rare malignant tumor arising from olfactory neuroepithelium. PET/CT with different tracers such as 18F-FDG and 68Ga-somatostatin-receptor tracers has demonstrated its utility for the evaluation of disease. We present the case of a woman previously treated for esthesioneuroblastoma performing MR and 18Ga-DOTATOC PET/CT demonstrating dural metastasis of disease with a strong correspondence between conventional and functional imaging.


Assuntos
Estesioneuroblastoma Olfatório/patologia , Carcinomatose Meníngea/diagnóstico por imagem , Carcinomatose Meníngea/secundário , Cavidade Nasal/patologia , Neoplasias Nasais/patologia , Compostos Organometálicos , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Feminino , Humanos , Pessoa de Meia-Idade
17.
Clin Nucl Med ; 46(7): e389-e390, 2021 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-33630795

RESUMO

ABSTRACT: Somatostatin cell surface receptors are expressed in many different benign and malignant tumors and are often exploited for imaging and therapy of neuroendocrine tumors. A 17-year-old adolescent boy with clinicoradiologically diagnosed JNA (juvenile nasopharyngeal angiofibroma) also underwent 68Ga-DOTANOC PET to explore somatostatin cell surface receptors' expression and its theranostic potential. Fusion PET/MRI, a novel imaging technology, exactly depicted the anatomical extensions of the tumor with avid DOTANOC uptake. This software-based fusion technique is advantageous for easy early recurrence identification, better delineation from postoperative scar tissue, for planning the exact target volumes for stereotactic radiotherapy therapy of inoperable/residual/recurrent JNAs in the future.


Assuntos
Angiofibroma/diagnóstico por imagem , Imageamento por Ressonância Magnética , Imagem Multimodal , Neoplasias Nasais/diagnóstico por imagem , Compostos Organometálicos , Tomografia por Emissão de Pósitrons , Adolescente , Angiofibroma/patologia , Humanos , Masculino , Neoplasias Nasais/patologia
18.
Vet Radiol Ultrasound ; 62(4): e40-e43, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33634903

RESUMO

A 6-year-old dog presented with a modified Adams stage 3 angiofibroma of the right nasal cavity, causing fluid accumulation along the right frontal sinus. Treatment consisted of step-and-shoot intensity-modulated radiation therapy in 12 daily treatments of 3.5 Gy, for a total dose of 42 Gy to 95% of the planning target volume. The dog developed self-limiting grade 2 oral mucositis which resolved within 2 weeks of course completion. A recheck exam 668 days after treatment confirmed a stable disease response by RECIST and a tumor volume decrease of 55.4%.


Assuntos
Angiofibroma/veterinária , Doenças do Cão/radioterapia , Neoplasias Nasais/veterinária , Radioterapia de Intensidade Modulada/veterinária , Angiofibroma/patologia , Angiofibroma/radioterapia , Animais , Doenças do Cão/patologia , Cães , Humanos , Masculino , Neoplasias Nasais/patologia , Neoplasias Nasais/radioterapia , Dosagem Radioterapêutica/veterinária , Planejamento da Radioterapia Assistida por Computador/veterinária , Resultado do Tratamento , Carga Tumoral
19.
Ann Otol Rhinol Laryngol ; 130(9): 1016-1023, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33514267

RESUMO

OBJECTIVES: Advanced cutaneous squamous cell carcinoma of the head and neck (CSCCHN) is associated with poor outcome despite multimodality therapy. Comprehensive risk stratification may pinpoint the most suitable adjuvant treatment. This study aimed to evaluate the outcomes of surgically treated locoregional CSCCHN and to identify prognostic indicators of treatment outcomes. METHODS: We retrospectively analyzed disease variables, pathologic characteristics, and management in association with treatment outcomes of all consecutive advanced CSCCHN patients who underwent surgical resection at Tel Aviv Sourasky Medical Center. RESULTS: From 2008 to 2018, 74 patients met the inclusion criteria. Only perineural invasion (PNI) was significantly associated with worse overall survival (OS) (P = .001). Location within the facial "mask areas" was significantly associated with pathologically negative cervical disease (P = .001). Forty-seven patients underwent adjuvant radiation therapy (RT) which significantly improved OS and disease-free survival versus surgery alone (P = .025 and P = 0.035, respectively). CONCLUSION: PNI was associated with worse OS in surgically treated advanced CSCCHN. Adjuvant RT conferred better outcomes despite high risk features.


Assuntos
Neoplasias Faciais/cirurgia , Linfonodos/patologia , Esvaziamento Cervical , Radioterapia Adjuvante , Couro Cabeludo/cirurgia , Neoplasias Cutâneas/cirurgia , Carcinoma de Células Escamosas de Cabeça e Pescoço/cirurgia , Idoso , Idoso de 80 Anos ou mais , Bochecha/patologia , Bochecha/cirurgia , Quimiorradioterapia Adjuvante , Intervalo Livre de Doença , Neoplasias da Orelha/patologia , Neoplasias da Orelha/cirurgia , Extensão Extranodal/patologia , Neoplasias Palpebrais/patologia , Neoplasias Palpebrais/cirurgia , Neoplasias Faciais/patologia , Feminino , Testa/patologia , Testa/cirurgia , Humanos , Hospedeiro Imunocomprometido , Estimativa de Kaplan-Meier , Neoplasias Labiais/patologia , Neoplasias Labiais/cirurgia , Masculino , Margens de Excisão , Pessoa de Meia-Idade , Gradação de Tumores , Invasividade Neoplásica , Recidiva Local de Neoplasia , Neoplasias Nasais/patologia , Neoplasias Nasais/cirurgia , Procedimentos Cirúrgicos Otorrinolaringológicos , Glândula Parótida , Modelos de Riscos Proporcionais , Procedimentos Cirúrgicos Reconstrutivos , Couro Cabeludo/patologia , Neoplasias Cutâneas/patologia , Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia , Taxa de Sobrevida , Resultado do Tratamento
20.
Am J Otolaryngol ; 42(2): 102851, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33385873

RESUMO

BACKGROUND: Sinonasal carcinoma with neuroendocrine differentiation (SCND) is a rare group of tumors with poor prognosis. Treatment and sequence of therapies are still unclear. The goal of this study is to analyze treatment outcomes in SCND using a national database. METHODS: The National Cancer Database was queried for SCND from 2004 to 2014. Patient demographics, tumor characteristics and treatment paradigms were tabulated. Multivariable Cox proportional hazards regression was performed for statistical analysis of treatment regimen on overall survival (OS). RESULTS: A total of 415 patients were identified. Most patients were male (61.2%), with a median age of 58 years and the most common primary site was the nasal cavity (52.5%). T4 tumors were observed in 67.7% of cases. Unimodality (41.9%) and bimodality (43.9%) therapies were the most common treatment modalities. Radiation therapy was the only treatment administered in 30% of the patients, while 27.2% received definitive chemoradiation (CRT) and 11.6% had surgery with adjuvant CRT. In our Cox-PH model, age (HR = 1.04, p < 0.001), T4 (HR = 2.6, p = 0.004) and N2/N3 (HR = 2.18, p = 0.001) were associated with worse survival. Trimodality (HR = 0.49, p = 0.005) and bimodality (HR = 0.65, p = 0.009) therapies had a better OS compared to unimodality. Patients treated with definitive CRT or surgery with adjuvant CRT had a significant increase in OS (p = 0.01 and 0.002 respectively). CONCLUSION: SCND appears to be best treated using a multimodality approach with definitive CRT or surgery followed by CRT. Neoadjuvant chemotherapy could be helpful in selecting the best treatment strategy.


Assuntos
Carcinoma Neuroendócrino/terapia , Cavidade Nasal , Neoplasias Nasais/terapia , Seios Paranasais , Fatores Etários , Carcinoma Neuroendócrino/mortalidade , Carcinoma Neuroendócrino/patologia , Quimiorradioterapia Adjuvante , Terapia Combinada , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Terapia Neoadjuvante , Estadiamento de Neoplasias , Neoplasias Nasais/mortalidade , Neoplasias Nasais/patologia , Procedimentos Cirúrgicos Otorrinolaringológicos/métodos , Radioterapia , Taxa de Sobrevida , Resultado do Tratamento
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