Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 4.294
Filtrar
2.
Anticancer Res ; 39(10): 5231-5259, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31570421

RESUMO

BACKGROUND/AIM: Prostate cancer is one of the most common cancers in men which remains a global public health issue. Treatment of prostate cancer is becoming increasingly intensive and aggressive, with a corresponding increase in resistance, toxicity and side effects. This has revived an interest in nontoxic and cost-effective preventive strategies including dietary compounds due to the multiple effects they have been shown to have in various oncogenic signalling pathways, with relatively few significant adverse effects. MATERIALS AND METHODS: To identify such dietary components and micronutrients and define their prostate cancer-specific actions, we systematically reviewed the current literature for the pertinent mechanisms of action and effects on the modulation of prostate carcinogenesis, along with relevant updates from epidemiological and clinical studies. RESULTS: Evidence from various recent experimental, clinical and epidemiological studies indicates that select dietary micronutrients (i.e., lycopene, epigallocatechin gallate, sulforaphane, indole-3-carbinol, resveratrol, quercetin, curcumin & piperine) and zinc play a key role in prostate cancer prevention and progression and therefore hold great promise for the future overall management of prostate cancer. CONCLUSION: A formulation that comprises these micronutrients using the optimal, safest form and dosing should be investigated in future prostate cancer chemoprevention studies and as part of standard prostate cancer therapy.


Assuntos
Produtos Biológicos/farmacologia , Produtos Biológicos/uso terapêutico , Próstata/efeitos dos fármacos , Neoplasias da Próstata/tratamento farmacológico , Neoplasias da Próstata/prevenção & controle , Animais , Quimioprevenção/métodos , Dieta/métodos , Estudos Epidemiológicos , Humanos , Masculino , Micronutrientes/farmacologia , Micronutrientes/uso terapêutico
4.
Afr Health Sci ; 19(1): 1665-1670, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31148996

RESUMO

Background: Despite the increasing incidence of Prostate cancer, there has not been any focused screening policy or strategy in sub-Saharan Africa including Nigeria. Objectives: To assess the level of awareness and uptake of PSA screening test and their determinants in a Nigerian community. Methods: A cross-sectional population survey of men with no prior history of prostate cancer was carried out. Logistic regression analysis was used to determine the effect of identified variables in predicting awareness and uptake of prostate cancer screening. Results: Mean age was 51.5±9.8 years; a few men (31, 16.9%) had ever heard of the screening test and most got the information from health centers. A low proportion (8, 4.4%) had taken the screening test. Men with incomes above poverty line (OR = 11.7 2.8-50.1, p = .001) or those with health insurance (OR = 2.7 1.2-6.5, p = .023) were significantly more likely to be aware of the test. Only the men with higher incomes (OR = 25.6 5.8-114.2, p = .0001) were significantly more likely to have taken the test. Conclusion: Higher incomes and health insurance status impact screening awareness but only income status determines if men subsequently proceed to take the PSA screening test.


Assuntos
Detecção Precoce de Câncer/estatística & dados numéricos , Programas de Rastreamento/estatística & dados numéricos , Antígeno Prostático Específico/sangue , Neoplasias da Próstata/diagnóstico , Neoplasias da Próstata/prevenção & controle , Adulto , Estudos Transversais , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Masculino , Programas de Rastreamento/métodos , Pessoa de Meia-Idade , Nigéria/epidemiologia , Neoplasias da Próstata/sangue , Neoplasias da Próstata/etnologia , Inquéritos e Questionários
5.
Public Health ; 173: 42-47, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31254676

RESUMO

OBJECTIVES: The aim of this analysis was to examine the association between public healthcare eligibility combined with private health insurance (PHI) status and the uptake of breast and prostate cancer screening services among middle and older age groups in Ireland. STUDY DESIGN: This is a cross-sectional analysis using The Irish Longitudinal Study on Ageing (TILDA). METHODS: The analysis included 6902 people aged 50 years and older who completed an in-house interview as part of TILDA. The interview collects information on a range of demographic, socio-economic, health and health service usage variables including the uptake of cancer screening services. An eligibility variable was created using information on public healthcare entitlement and PHI status. The association between eligibility and the uptake of two cancer screening services-mammogram and prostate-specific antigen (PSA) test-was examined using weighted multivariate logistic regression analysis. RESULTS: The uptake of a mammogram and PSA testing was significantly higher in those with PHI. This relationship held after controlling for a range of confounders including health and socio-economic status. CONCLUSIONS: More research is required to identify the reasons for the higher uptake of cancer screening services among those with PHI, given that insurance does not confer any advantages in accessing these services. It is possible that the higher uptake is explained by differential access to secondary care services between those with and without PHI. Consideration of the integrated nature of healthcare systems is essential when seeking to maximise the uptake of services (such as cancer screening) that potentially involve multiple parts of the healthcare system.


Assuntos
Neoplasias da Mama/diagnóstico , Detecção Precoce de Câncer/estatística & dados numéricos , Acesso aos Serviços de Saúde/estatística & dados numéricos , Serviços de Saúde/estatística & dados numéricos , Mamografia/estatística & dados numéricos , Neoplasias/diagnóstico , Antígeno Prostático Específico , Neoplasias da Próstata/diagnóstico , Idoso , Neoplasias da Mama/prevenção & controle , Estudos Transversais , Definição da Elegibilidade , Feminino , Humanos , Seguro Saúde , Irlanda , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Neoplasias/prevenção & controle , Neoplasias da Próstata/prevenção & controle , Classe Social , Fatores Socioeconômicos
7.
Asian Pac J Cancer Prev ; 20(5): 1393-1401, 2019 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-31127898

RESUMO

Background and objective: The second most common cancer in men after lung cancer is prostate cancer (PC). Previous studies assessed the association between food items or food groups and the risk of PC, but diet quality indices are unique approaches to study any relations between diet and disease. Our objective was to investigate the effect of healthy eating index (HEI-2010) and Mediterranean-Style Dietary Pattern Score (MSDPS) on PC risk. Methods: In this case-control study, we recruited 97 patients with MS and 205 control subjects . Dietary intake was evaluted using a valid and reliable food frequency questionnaire. The HEI and MSDPS were calculated. Logistic regression was used to evaluate the relationship between HEI and MSDP scores and PC risk after adjusting the confounders. Results: In comparison to controls, cases had lower score on HEI (61 vs. 70.07; P< 0.001), and higher score on MSDP (26.20 vs. 24.49; P= 0.44). After comparing the highest and the lowest tertile of HEI, we observed a significant decreasing trend in the risk of PC (p for trend<0.001). Conclusion: Our findings suggested that a high quality diet, according to HEI, may decrease the risk of PC.


Assuntos
Dieta/efeitos adversos , Comportamento Alimentar , Estilo de Vida , Neoplasias da Próstata/etiologia , Neoplasias da Próstata/prevenção & controle , Índice de Massa Corporal , Estudos de Casos e Controles , Seguimentos , Humanos , Irã (Geográfico)/epidemiologia , Masculino , Pessoa de Meia-Idade , Estado Nutricional , Cooperação do Paciente , Prognóstico , Neoplasias da Próstata/epidemiologia , Fatores de Risco
8.
Asian Pac J Cancer Prev ; 20(5): 1415-1420, 2019 May 25.
Artigo em Inglês | MEDLINE | ID: mdl-31127901

RESUMO

Background: Prostate cancer is the second common cancer in the world. Although some associations between dietary intakes and prostate cancer have been found, the effects of dietary nutrients interactions have not yet evaluated. The aim of this study is to assess the association between nutrient patterns and risk of prostate cancer. Methods and Materials: Ninety-seven patients with prostate cancer and 205 controls were asked about their demographic and dietary intakes using validated questionnaires. To extract nutrient patterns, Principal Component Analysis (PCA) based on the 35 nutrient items were applied. Varimax rotation was used for improving interpretation and minimizing correlation between the factors. Logistic regression was used to determine the odds ratio (OR) with 95% confidence interval (CI) of prostate cancer by higher scores on the nutrient patterns. Results: High adherence to the "plant source" pattern was negatively associated with prostate cancer risk (OR 0.29 for the highest vs. the lowest score tertile; 95% CI= 0.13 ­ 0.65; P value for trend:<0.003). Similarly, the "antioxidant and fiber" pattern was associated with decreasing risk of prostate cancer (OR 0.06 for the highest vs. the lowest score tertile;95% CI=0.02 ­ 0.19; P value for trend:<0.001). There was no significant association for the "mixed" and "vitamin and minerals" pattern with risk of prostate cancer. Conclusion: This study confirms the potential and important role of nutrients on prostate cancer risk. Our finding revealed that "antioxidant and fiber" and "plant source" pattern is inversely associated with prostate cancer risk; however, further longitudinal and trial studies are needed to make a firm conclusion.


Assuntos
Dieta/efeitos adversos , Comportamento Alimentar , Estilo de Vida , Nutrientes/administração & dosagem , Neoplasias da Próstata/etiologia , Neoplasias da Próstata/prevenção & controle , Estudos de Casos e Controles , Seguimentos , Humanos , Irã (Geográfico)/epidemiologia , Masculino , Pessoa de Meia-Idade , Nutrientes/efeitos adversos , Estado Nutricional , Prognóstico , Neoplasias da Próstata/epidemiologia , Fatores de Risco
9.
Nat Rev Cancer ; 19(6): 349-358, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31024081

RESUMO

For cancer screening to be successful, it should primarily detect cancers with lethal potential or their precursors early, leading to therapy that reduces mortality and morbidity. Screening programmes have been successful for colon and cervical cancers, where subsequent surgical removal of precursor lesions has resulted in a reduction in cancer incidence and mortality. However, many types of cancer exhibit a range of heterogeneous behaviours and variable likelihoods of progression and death. Consequently, screening for some cancers may have minimal impact on mortality and may do more harm than good. Since the implementation of screening tests for certain cancers (for example, breast and prostate cancers), a spike in incidence of in situ and early-stage cancers has been observed, but a link to reduction in cancer-specific mortality has not been as clear. It is difficult to determine how many of these mortality reductions are due to screening and how many are due to improved treatments of tumours. In cancers with lower incidence but high mortality (for example, pancreatic cancer), screening has focused on high-risk populations, but challenges similar to those for general population screening remain, particularly with regard to finding lesions with difficult-to-characterize malignant potential (for example, intraductal papillary mucinous neoplasms). More sensitive screening methods are detecting smaller and smaller lesions, but this has not been accompanied by a comparable reduction in the incidence of invasive cancers. In this Opinion article, we focus on the contribution of screening in general and high-risk populations to overdiagnosis, the effects of overdiagnosis on patients and emerging strategies to reduce overdiagnosis of indolent cancers through an understanding of tumour heterogeneity, the biology of how cancers evolve and progress, the molecular and cellular features of early neoplasia and the dynamics of the interactions of early lesions with their surrounding tissue microenvironment.


Assuntos
Sobremedicalização , Neoplasias/diagnóstico , Neoplasias/prevenção & controle , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/prevenção & controle , Feminino , Humanos , Incidência , Masculino , Programas de Rastreamento , Neoplasias/epidemiologia , Neoplasias/patologia , Neoplasias Pancreáticas/diagnóstico , Neoplasias Pancreáticas/epidemiologia , Neoplasias Pancreáticas/prevenção & controle , Neoplasias da Próstata/diagnóstico , Neoplasias da Próstata/prevenção & controle , Microambiente Tumoral
10.
Am J Clin Nutr ; 109(4): 1133-1144, 2019 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-30982861

RESUMO

BACKGROUND: Epidemiological evidence suggests that consumption of cruciferous vegetables is associated with reduced risk of prostate cancer progression, largely attributed to the biological activity of glucosinolate degradation products, such as sulforaphane derived from glucoraphanin. Because there are few therapeutic interventions for men on active surveillance for prostate cancer to reduce the risk of cancer progression, dietary approaches are an appealing option for patients. OBJECTIVE: We evaluated whether consumption of a glucoraphanin-rich broccoli soup for 1 y leads to changes in gene expression in prostate tissue of men with localized prostate cancer. METHODS: Forty-nine men on active surveillance completed a 3-arm parallel randomized double-blinded intervention study for 12 mo and underwent transperineal template biopsy procedures and dietary assessment at the start and end of the study. Patients received a weekly 300 mL portion of soup made from a standard broccoli (control) or from 1 of 2 experimental broccoli genotypes with enhanced concentrations of glucoraphanin, delivering 3 and 7 times that of the control, respectively. Gene expression in tissues from each patient obtained before and after the dietary intervention was quantified by RNA sequencing followed by gene set enrichment analyses. RESULTS: In the control arm, there were several hundred changes in gene expression in nonneoplastic tissue during the 12 mo. These were associated with an increase in expression of potentially oncogenic pathways including inflammation processes and epithelial-mesenchymal transition. Changes in gene expression and associated oncogenic pathways were attenuated in men on the glucoraphanin-rich broccoli soup in a dose-dependent manner. Although the study was not powered to assess clinical progression, an inverse association between consumption of cruciferous vegetables and cancer progression was observed. CONCLUSION: Consuming glucoraphanin-rich broccoli soup affected gene expression in the prostate of men on active surveillance, consistent with a reduction in the risk of cancer progression. This trial was registered at clinicaltrials.gov as NCT01950143.


Assuntos
Brassica/metabolismo , Glucosinolatos/metabolismo , Imidoésteres/metabolismo , Isotiocianatos/metabolismo , Próstata/metabolismo , Neoplasias da Próstata/genética , Neoplasias da Próstata/prevenção & controle , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Expressão Gênica , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias da Próstata/metabolismo , Transcrição Genética , Adulto Jovem
11.
J BUON ; 24(1): 227-232, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30941974

RESUMO

PURPOSE: To determine the associations among diabetes status, Metformin administration and prostate cancer (PCa) detection at biopsy in Chinese population. METHODS: A case-control study was conducted among a prospectively enrolled prostate biopsy cohort of 518 patients from Jan 2013 to Dec 2014 at our institute. Diabetes status and Metformin administration were determined through medical records and self-report. Different clinical characteristics were registered and compared among different groups. Univariate and multivariate logistic regression analyses were performed to evaluate the effects of diabetes status and Metformin administration on the detection of overall as well as high-grade PCa at biopsy. RESULTS: PCa was detected in 229 (44.2%) men, and high-grade PCa (Gleason score ≥8) was detected in 65 (12.5%) men. Diabetes was observed in 96 men, and 28 of them were administered with Metformin. Both overall and high-grade cancer detection rates were significantly higher in diabetic patients (p<0.001). In multivariate analysis, diabetes status was a risk factor for high-grade cancer detection (OR 7.699, 95%CI 3.483-17.020, p<0.001), but not for total PCa detection (OR 1.774, 95%CI 0.831-3.787, p=0.138). Meanwhile, Metformin administration was proved to be a protective factor for high-grade disease (OR 0.420, 95%CI 0.201-0.879, p=0.021) in multivariate analysis, while no correlation was detected with overall cancer detection (OR 0.786, 95%CI 0.172-3.593, p=0.756). CONCLUSIONS: Diabetes status was positively associated with biopsy-mediated high-grade PCa detection in Chinese population, while the positive association would be partly compromised by Metformin administration.


Assuntos
Hipoglicemiantes/administração & dosagem , Metformina/administração & dosagem , Neoplasias da Próstata/prevenção & controle , Substâncias Protetoras/administração & dosagem , Idoso , Biópsia , Estudos de Casos e Controles , China , Diabetes Mellitus , Seguimentos , Humanos , Masculino , Gradação de Tumores , Estudos Prospectivos , Neoplasias da Próstata/diagnóstico
12.
Enferm. glob ; 18(54): 250-261, abr. 2019. graf
Artigo em Espanhol | IBECS | ID: ibc-183483

RESUMO

El artículo objetivó describir la percepción de los hombres sobre el cáncer de próstata y los factores de prevención relacionados. Se trata de un estudio cualitativo del tipo de ensayo comunitario. Se realizaron tres reuniones en forma de grupo focal, compuesto por 60 hombres con rango de edad superior a 40 años, abordando el tema del cáncer de próstata. Para el análisis de los datos cualitativos se realizó el análisis de contenido temático y los datos fueron organizados en el software - Atlas Ti. Los resultados fueron referenciados en los objetivos de este estudio y enfatizados en categorías. Los datos evidenciaron que todavía hay una barrera física y social a ser superada ante los estigmas masculinos, y existe una carencia de conocimiento sobre la prevención de este cáncer. El aumento de la oferta de exámenes diagnósticos, agilidad en la atención, horarios diferenciados para los trabajadores son algunas de las estrategias eficientes para atraer a esta población para la prevención del cáncer de próstata


O artigo objetivou descrever a percepção dos homens sobre o câncer de próstata e os fatores de prevenção relacionados. Trata-se de um estudo qualitativo do tipo ensaio comunitário. Foram realizadas três reuniões em forma de grupo focal, composto por 60 homens com faixa etária superior a 40 anos, abordando o tema do câncer de próstata. Para a análise dos dados qualitativos foi realizada a análise de conteúdo temática e os dados foram organizados no software - Atlas Ti. Os resultados foram referenciados nos objetivos deste estudo e enfatizados em categorias. Os dados evidenciaram que ainda há uma barreira física e social a ser ultrapassada diante dos estigmas masculinos, e existe uma carência de conhecimento sobre a prevenção deste câncer. O aumento da oferta de exames diagnósticos, agilidade no atendimento, horários diferenciados para os trabalhadores são algumas das estratégias eficientes para atrair esta população para a prevenção do câncer de próstata


The article aimed to describe the men's perception about prostate cancer and related prevention factors. This is a qualitative community trial type study. Three meetings were held in the form of a focus group, composed of 60 men aged over 40 years old, addressing the topic of prostate cancer. In order to analyze the qualitative data, thematic content analysis was performed and the data were organized in the software - Atlas Ti. The results were referenced in the objectives of this study and emphasized into categories. The data showed that there is still a physical and social barrier to overcome with male stigmas, and there is a lack of knowledge about the prevention of this cancer. The increase in the availability of diagnostic tests, agility in care, and differentiated schedules for workers are some of the efficient strategies to attract this population to the prevention of prostate cancer


Assuntos
Humanos , Masculino , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Neoplasias da Próstata/prevenção & controle , Promoção da Saúde/métodos , Detecção Precoce de Câncer/enfermagem , Neoplasias da Próstata/enfermagem , Conhecimentos, Atitudes e Prática em Saúde , Prevenção Primária/métodos , Fatores de Risco
14.
Magy Onkol ; 63(1): 60-64, 2019 Mar 19.
Artigo em Húngaro | MEDLINE | ID: mdl-30889622

RESUMO

As a result of the growing incidence of cancer as well as increased survival of patients, an increasing number of people are living longer with cancer. In recent years, research has shown that physical activity not only protects against a number of cancer types, but is also valuable for patients undergoing cancer treatment and during the rehabilitation phase, as well as for improving function and quality of life. Regular physical activity is an effective way to reduce the side effects of cancer, resulting in part from physical inactivity and in part from the disease itself. Too much rest can lead to a decrease in aerobic fitness, strength, mobility and unwanted weight gain in the patient. In prostate cancer patients, hormonal treatment especially accelerates this process. In this paper we summarize the available evidence concerning the role of exercise in prostate cancer prevention, treatment and rehabilitation.


Assuntos
Exercício/fisiologia , Neoplasias da Próstata/prevenção & controle , Neoplasias da Próstata/terapia , Humanos , Masculino , Neoplasias da Próstata/tratamento farmacológico , Neoplasias da Próstata/reabilitação , Qualidade de Vida
15.
Prostate ; 79(7): 778-783, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30905089

RESUMO

BACKGROUND: Genetic counseling (GC) and genetic testing (GT) for prostate cancer (PCA) is a rapidly growing, affording opportunity for healthy lifestyle promotion in men aligned with cancer survivorship and cancer prevention goals. We conducted a targeted dietary analysis of men undergoing GC/GT for PCA for adherence to the United States Department of Agriculture (USDA) Food Pattern recommendations which align with preventing cancer and recurrences in the Genetic Evaluation of Men (GEM) study at two academic centers to inform future strategies for diet intervention. METHODS: Participants of GEM with PCA or at-risk for PCA completed a structured food frequency questionnaire indicating number of servings consumed per day or per week of fruits, vegetables, red meat, seafood, processed meat, and foods high in saturated fat. Adherence to the USDA recommendations was assessed for the total sample and by PCA status and aggressiveness, family history, and body mass index (BMI) through χ 2 contingency analyses. One-sample t tests were used to compare the dietary behaviors of men to USDA Recommendations. Levels of α were set a priori at P < 0.05. RESULTS: Of 239 males undergoing GC on the study, surveys were completed by 197 men (82.4%), and complete survey data was available on 113 men (47.3%). By the Centers for Disease Control and Prevention BMI classification, 82.3% of the cohort was overweight (45.1%) or obese (37.2%). GEM participants reported consuming less fruits (P = 0.015), less vegetables ( P < 0.001), less seafood ( P < 0.001), more processed meats ( P < 0.001), and more foods high in saturated fats ( P < 0.001) than recommended. CONCLUSION: A high proportion of men receiving GC/GT for PCA were overweight and/or obese with lack of adherence to national diet recommendations for cancer risk and recurrence, affording a teachable moment and supporting the systematic focus of introducing nutrition intervention during GC to promote survivorship.


Assuntos
Avaliação Nutricional , Obesidade/complicações , Neoplasias da Próstata/dietoterapia , Neoplasias da Próstata/prevenção & controle , Idoso , Índice de Massa Corporal , Aconselhamento Genético , Testes Genéticos , Estilo de Vida Saudável , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade/dietoterapia , Sobrepeso/complicações , Sobrepeso/dietoterapia , Cooperação do Paciente , Neoplasias da Próstata/etiologia , Neoplasias da Próstata/terapia , Medição de Risco
16.
Int J Mol Sci ; 20(5)2019 Mar 03.
Artigo em Inglês | MEDLINE | ID: mdl-30832393

RESUMO

Extensive research over the past 25 years in hormone-dependent cancers, such as breast cancer and prostate cancer, has identified the molecular mechanisms driven by steroid receptors, elucidating the interplay between genomic and non-genomic steroid receptors mechanism of action. Altogether, these mechanisms create the specific gene expression programs that contribute to endocrine therapy resistance and cancer progression. These findings, on the bidirectional molecular crosstalk between steroid and growth factor receptors pathways in endocrine resistance, suggest the use of multi-target inhibitors together with endocrine therapies, for treating resistant disease. In this review we will discuss the novel understanding on the chemopreventive and anti-cancer activities of Resveratrol (3,5,4'-trihydroxy-stilbene) (RSV), a phytoalexin found in grapes acting on a plethora of targets. We will highlight Resveratrol effect on steroid receptors signalling and its potential use in the treatment of hormone-dependent cancer. Understanding the molecular mechanisms by which the bioactive compound influences cancer cell behaviour, by interfering with steroid receptors functional activity, will help to advance the design of combination strategies to increase the rate of complete and durable clinical response in patients.


Assuntos
Anticarcinógenos/farmacologia , Antineoplásicos/farmacologia , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Próstata/tratamento farmacológico , Receptores de Esteroides/metabolismo , Resveratrol/farmacologia , Animais , Anticarcinógenos/uso terapêutico , Antineoplásicos/uso terapêutico , Neoplasias da Mama/prevenção & controle , Feminino , Humanos , Masculino , Neoplasias da Próstata/prevenção & controle , Resveratrol/uso terapêutico , Transdução de Sinais/efeitos dos fármacos
19.
Nutrients ; 11(2)2019 Feb 04.
Artigo em Inglês | MEDLINE | ID: mdl-30720759

RESUMO

Prostate cancer (PC) is one of the most common cancers in men. The global burden of this disease is rising. Its incidence and mortality rates are higher in African American (AA) men compared to white men and other ethnic groups. The treatment decisions for PC are based exclusively on histological architecture, prostate-specific antigen (PSA) levels, and local disease state. Despite advances in screening for and early detection of PC, a large percentage of men continue to be diagnosed with metastatic disease including about 20% of men affected with a high mortality rate within the African American population. As such, this population group may benefit from edible natural products that are safe with a low cost. Hence, the central goal of this article is to highlight PC disparity associated with nutritional factors and highlight chemo-preventive agents from medicinal plants that are more likely to reduce PC. To reach this central goal, we searched the PubMed Central database and the Google Scholar website for relevant papers. Our search results revealed that there are significant improvements in PC statistics among white men and other ethnic groups. However, its mortality rate remains significantly high among AA men. In addition, there are limited studies that have addressed the benefits of medicinal plants as chemo-preventive agents for PC treatment, especially among AA men. This review paper addresses this knowledge gap by discussing PC disparity associated with nutritional factors and highlighting the biomedical significance of three medicinal plants (curcumin, garlic, and Vernonia amygdalina) that show a great potential to prevent/treat PC, as well as to reduce its incidence/prevalence and mortality, improve survival rate, and reduce PC-related health disparity.


Assuntos
Afro-Americanos/estatística & dados numéricos , Anticarcinógenos/uso terapêutico , Disparidades nos Níveis de Saúde , Fitoterapia/métodos , Neoplasias da Próstata/prevenção & controle , Adulto , Idoso , Curcumina/uso terapêutico , Alho , Humanos , Masculino , Pessoa de Meia-Idade , Plantas Medicinais , Neoplasias da Próstata/etnologia , Neoplasias da Próstata/mortalidade , Vernonia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA