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1.
Adv Exp Med Biol ; 1287: 81-103, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33034028

RESUMO

Head and neck cancer is a group of neoplastic diseases affecting the facial, oral, and neck region. It is one of the most common cancers worldwide with an aggressive, invasive evolution. Due to the heterogeneity of the tissues affected, it is particularly challenging to study the molecular mechanisms at the basis of these tumors, and to date we are still lacking accurate targets for prevention and therapy. The Notch signaling is involved in a variety of tumorigenic mechanisms, such as regulation of the tumor microenvironment, aberrant intercellular communication, and altered metabolism. Here, we provide an up-to-date review of the role of Notch in head and neck cancer and draw parallels with other types of solid tumors where the Notch pathway plays a crucial role in emergence, maintenance, and progression of the disease. We therefore give a perspective view on the importance of the pathway in neoplastic development in order to define future lines of research and novel therapeutic approaches.


Assuntos
Neoplasias de Cabeça e Pescoço , Receptores Notch , Neoplasias de Cabeça e Pescoço/metabolismo , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Transdução de Sinais , Microambiente Tumoral
2.
Texto & contexto enferm ; 29: e20180343, Jan.-Dec. 2020. tab
Artigo em Inglês | LILACS, BDENF - Enfermagem | ID: biblio-1094553

RESUMO

ABSTRACT Objective: To evaluate the association between sociodemographic, clinical, and treatment factors in the outcome of severe radiodermatitis in patients with head and neck cancer seen at the nursing consultation; and to analyze the impact of severe radiodermatitis cases on therapeutic follow-up. Method: A quantitative, documentary research conducted with medical records of 167 patients with head and neck cancer submitted to radiotherapy with curative indication followed in the nursing consultation in 2016. A structured form was used for data collection and analytical and descriptive statistics were used for its analysis. Results: Of the 99.4% patients who had radiodermatitis, 11.4% were severe cases. Severe radiodermatitis was associated with the type of equipment, treatment technique and presence of comorbidities. Of the patients who presented grade three, 53% had temporary discontinuation of treatment. Conclusion: Head and neck cancer patients who undergo radiotherapy with curative indication are at risk for severe radiodermatitis. Nursing consultation is important to minimize the severity of this event and the reduction of temporary treatment interruption due to this adverse reaction.


RESUMEN Objetivo: evaluar la asociación entre los factores sociodemográficos, clínicos y de tratamiento en los resultados de la radiodermatitis grave en pacientes con cáncer de cuello y cabeza atendidos en una consulta de enfermería, además de analizar el efecto de los casos de radiodermatitis grave sobre el seguimiento terapéutico. Método: investigación cuantitativa y documental realizada con expedientes médicos de 167 pacientes con cáncer de cuello y cabeza sometidos a radioterapia con prescripción de cura, con seguimiento en consulta de enfermería en el año 2016. Se utilizó un formulario estructurado para recolectar los datos y se empleó analítica estadística para su análisis. Resultados: del99,4% de los pacientes que tuvieron dermatitis, el 11,4% de los casos fueron graves. La radiodermatitis grave se asoció al tipo de dispositivo, técnica de tratamiento y presencia de comorbidades. De los pacientes que presentaron el grado 3, el 53% suspendió temporariamente el tratamiento. Conclusión: los pacientes con cáncer de cuello y cabeza que se someten a radioterapia con prescripción de cura presentan cierto riesgo de radiodermatitis grave. La consulta de enfermería es importante para minimizar la gravedad de este evento y para reducir el índice de interrupción temporaria del tratamiento a raíz de esta reacción adversa.


RESUMO Objetivo: avaliar a associação entre os fatores sociodemográficos, clínicos e do tratamento no desfecho de radiodermatite severa em pacientes portadores de câncer de cabeça e pescoço atendidos na consulta de enfermagem; e analisar o impacto dos casos de radiodermatite severa no seguimento terapêutico. Método: pesquisa quantitativa, documental, realizada com prontuários de 167 pacientes com câncer de cabeça e pescoçosubmetidos à radioterapiacom indicação curativa acompanhados na consulta de enfermagem no ano de 2016. Utilizou-se um formulário estruturado para a coleta de dados e empregou-se estatística analítica e descritiva para sua análise. Resultados: dos 99,4% pacientes quetiveramradiodermatite,11,4% foramseveras. A radiodermatite severa se associou ao tipo de aparelho, técnica de tratamento e presença de comorbidades. Dos pacientes que apresentaram grau três, 53% tiveram suspensão temporária do tratamento. Conclusão: pacientes com câncer de cabeça e pescoço que fazem radioterapia com indicação curativa apresentam risco para radiodermatite severa. A consulta de enfermagem é importante para minimizar a severidade deste evento ea diminuição da interrupção temporária do tratamento por esta reação adversa.


Assuntos
Humanos , Enfermagem Oncológica , Radiodermatite , Fatores de Risco , Neoplasias de Cabeça e Pescoço , Cuidados de Enfermagem
5.
Braz Oral Res ; 34: e120, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33146316

RESUMO

With the onset of the new coronavirus disease (COVID-19) pandemic, the dental treatment of patients at risk of infection has become quite challenging. In view of this, patients with head and neck cancer may present with oral complications due to anticancer therapy, making dental assistance necessary. Thus, the objective of the study was to review the literature and critically discuss important concerns about the treatment of patients with head and neck cancer during the COVID-19 pandemic. Because dental professionals are in close contact with the main viral transmission routes, this study presents recommendations for management and protection during clinical dental care. The main characteristics and transmission routes of COVID-19 are also discussed. Dental professionals should control pain and the side effects of antineoplastic treatment and use preventive measures for infection control. During this pandemic, patients with head and neck cancer should not undergo elective procedures, even if they do not have symptoms or a history of COVID-19; therefore, in asymptomatic or painless cases, only preventive actions are recommended. In symptomatic or painful cases, precautions for safe interventional treatments must be implemented by following the hygiene measures recommended by health agencies and using personal protective equipment. During health crises, new protocols emerge for cancer treatment, and professionals must act with greater attention toward biosafety and updated knowledge. It is important to offer adequate individualized treatment based on the recommendations of preventative and interventional treatments so that patients can face this difficult period with optimized quality of life.


Assuntos
Betacoronavirus , Infecções por Coronavirus , Neoplasias de Cabeça e Pescoço , Doenças da Boca/terapia , Pandemias , Pneumonia Viral , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Doenças da Boca/etiologia , Qualidade de Vida
6.
Nat Commun ; 11(1): 5667, 2020 11 09.
Artigo em Inglês | MEDLINE | ID: mdl-33168818

RESUMO

Poor tissue penetration remains a major challenge for antibody-based therapeutics of solid tumors, but proper dosing can improve the tissue penetration and thus therapeutic efficacy of these biologics. Due to dose-limiting toxicity of the small molecule payload, antibody-drug conjugates (ADCs) are administered at a much lower dose than their parent antibodies, which further reduces tissue penetration. We conducted an early-phase clinical trial (NCT02415881) and previously reported the safety of an antibody-dye conjugate (panitumumab-IRDye800CW) as primary outcome. Here, we report a retrospective exploratory analysis of the trial to evaluate whether co-administration of an unconjugated antibody could improve the intratumoral distribution of the antibody-dye conjugate in patients. By measuring the multiscale distribution of the antibody-dye conjugate, this study demonstrates improved microscopic antibody distribution without increasing uptake (toxicity) in healthy tissue when co-administered with the parent antibody, supporting further clinical investigation of the co-administration dosing strategy to improve the tumor penetration of ADCs.


Assuntos
Anticorpos/administração & dosagem , Anticorpos/uso terapêutico , Neoplasias de Cabeça e Pescoço/tratamento farmacológico , Imunoconjugados/administração & dosagem , Imunoconjugados/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Linhagem Celular Tumoral , Sistemas de Liberação de Medicamentos , Feminino , Neoplasias de Cabeça e Pescoço/patologia , Humanos , Indóis/administração & dosagem , Masculino , Pessoa de Meia-Idade , Ensaios Clínicos Controlados não Aleatórios como Assunto , Panitumumabe/administração & dosagem , Estudos Prospectivos , Estudos Retrospectivos
7.
Med Oral Patol Oral Cir Bucal ; 25(6): e769-e774, 2020 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-33037811

RESUMO

BACKGROUND: The aim was to examine the interval since first symptoms until final diagnosis of squamous cell carcinoma (SCC) in the head and neck region in southern Brazil. MATERIAL AND METHODS: The individuals were prospectively selected and underwent anamnesis, physical examination and interview in the first medical consultation at a Cancer Hospital from south of Brazil. RESULTS: From 488 patients who underwent clinical examination, 105 were included in the study with diagnosis of SCC. Patients average interval from first symptoms to final diagnosis was 152 days (median 86; max:1105; min: 1), the average professional interval was 108 days (median: 97; max:525; min: 1) , and the average total period interval was 258 days (median: 186; max:1177; min: 45). Factors statistically associated with patient and diagnosis itinerary intervals were smoking and poorly adapted dentures and distance from home to hospital, respectively. CONCLUSIONS: The identification of the itinerary characteristics of this specific population may reflect in more effective public policies, such as primary and secondary prevention programs, aiming to increase the survival of oncological patient. Furthermore, the knowledge of the variables that influence the late diagnosis minimizes patient's journey in search of care to cancer centers through health programs.


Assuntos
Carcinoma de Células Escamosas , Neoplasias de Cabeça e Pescoço , Brasil/epidemiologia , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/epidemiologia , Neoplasias de Cabeça e Pescoço/diagnóstico , Neoplasias de Cabeça e Pescoço/epidemiologia , Humanos , Pescoço , Fumar
8.
Hua Xi Kou Qiang Yi Xue Za Zhi ; 38(5): 489-494, 2020 Oct 01.
Artigo em Chinês | MEDLINE | ID: mdl-33085230

RESUMO

Anti-programmed cell death protein 1 (PD-1) monoclonal antibody is a landmark drug in the field of malignant tumor treatment, and its emergence has resulted in the use of immunotherapy in treating various types of malignancies. A large number of clinical studies abroad have shown that it has a more significant effect than traditional strategies in the treatment of advanced head and neck cancer, and it has a significantly lower incidence of adverse events than chemotherapy. Recently, the clinical application of anti-PD-1 monoclonal antibodies in China has changed the traditional treatment mode of head and neck malignant tumors. Immunotherapy has become the first-line treatment option for recurrent/metastatic head and neck cancer. Furthermore, the indications of PD-1 monoclonal antibodies have been continuously expanded through clinical trials, and their biomarkers have been explored and validated. The application of PD-1 monoclonal antibodies tend to be individualized and precise and potentially improves the treatment levels of advanced head and neck malignancies.


Assuntos
Neoplasias de Cabeça e Pescoço , Receptor de Morte Celular Programada 1 , Proteínas Reguladoras de Apoptose , China , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Imunoterapia , Recidiva Local de Neoplasia
9.
Shanghai Kou Qiang Yi Xue ; 29(4): 396-399, 2020 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-33089289

RESUMO

PURPOSE: To investigate the changes of salivary composition, flow and dry mouth in patients with head and neck squamous cell carcinoma after parotid sparing modulated radiation therapy. METHODS: One hundred and one patients with head and neck squamous cell carcinoma who received radiotherapy in Qingyang People's Hospital from May 2016 to November 2018 were selected and divided into intensity modulated radiation group(n=54) and conventional radiation group(n=47) according to different treatment methods. The clinicopathological parameters, parotid uptake index, salivary composition, dry mouth, oropharyngeal symptoms and grading were compared between the two groups. The data were analyzed with SPSS 20.0 software package. RESULTS: The tumor site, TNM stage and differentiation had no significant difference between the two groups(P>0.05). The concentration of total protein, secretory IgA, calcium and phosphorus in saliva of patients in intensity modulated radiation therapy group were significantly higher than those in conventional radiation group(P<0.05). The parotid uptake index, secretion index and salivary flow velocity were significantly decreased in both groups(P<0.05), and were significantly lower in the conventional radiation group than in the intensity modulated radiation group(P<0.05). Dry mouth condition in intensity modulated radiation group was significantly better than that in conventional radiation group(P<0.05). After treatment, the ratio of pharyngalgia and dysphagia patients in the intensity modulated radiation group was significantly lower than that in the conventional radiation group(P<0.05). The degree of oropharyngeal grading in the intensity modulated radiation therapy group was significantly better than that in the conventional radiation group(P<0.05). CONCLUSIONS: The application of parotid sparing retention modulated radiation therapy has little effect on salivary composition, flow rate and dry mouth, and has obvious protective effect on parotid secretion.


Assuntos
Neoplasias de Cabeça e Pescoço , Radioterapia de Intensidade Modulada , Xerostomia , Neoplasias de Cabeça e Pescoço/radioterapia , Humanos , Glândula Parótida , Saliva , Xerostomia/prevenção & controle
10.
Otolaryngol Clin North Am ; 53(6): 1159-1170, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33039099
11.
Crit Rev Oncol Hematol ; 156: 103115, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33039721

RESUMO

INTRODUCTION: Head and neck radiotherapy can cause hypofunction of the salivary glands. Many studies report that laser photobiomodulation (PBM) is able to minimize radiation-induced hyposalivation, yet there is no consensus about its effects. OBJECTIVE: To carry out a meta-analysis of controlled clinical trials that used PBM to prevent radiation-induced hyposalivation. METHODS: A systematic search was performed through Embase, Medline/PubMed, Cochrane, EBSCO, Scopus, LILACS and Web of Science databases. The strategy included comparisons of the effect of PBM with placebo/clinical follow-up on unstimulated and/or stimulated salivary flow in patients undergoing head and neck radiotherapy. RESULTS: Six clinical trials were included, five of which were used for meta-analysis. Evidence was observed between the use of PBM and increased unstimulated salivary flow (MD 0.20 mL/min, 95 % Cl 0.10-0.30, I² = 96 %, p < 0.00001) and in stimulated salivary flow (MD 0.27 mL/min, 95 % CI 0.08-0.46, I² = 95 %, p < 0.00001). CONCLUSION: PBM appears to minimize radiation-induced hyposalivation.


Assuntos
Neoplasias de Cabeça e Pescoço , Xerostomia , Neoplasias de Cabeça e Pescoço/radioterapia , Humanos , Glândulas Salivares , Xerostomia/etiologia , Xerostomia/prevenção & controle
12.
Crit Rev Oncol Hematol ; 156: 103116, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33115701

RESUMO

OBJECTIVES: to provide accurate information about the global prevalence of human papillomavirus (HPV) in oropharyngeal squamous cell carcinomas (OPSCC). MATERIAL AND METHODS: a systematic review was performed using three main electronic databases. Studies were independently assessed by two reviewers based on established eligibility criteria, to identify the prevalence of HPV-driven OPSCC following criteria defined by the American Society of Clinical Oncology. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Statistical software MedCalc was used to perform meta-analyses. RESULTS: from 2215 records found, 15 were included, reporting data from 6009 patients (time period range: 1980-2016), distributed in 11 countries. Eleven studies were considered as presenting low risk, and four as moderate risk of bias. Using proportion meta-analysis, pooled prevalence of HPV-driven OPSCC was 44.8 % (95 %CI: 36.4-53.5 %; i2 = 97.6 %), with the highest rates in New Zealand (74.5 %; 95 %CI: 60.9-85.3 %), and the lowest in Brazil (11.1 %; 95 %CI: 4.5-21.5 %). HPV prevalence was similar between males (45.7 %; 95 %CI: 36.5-55.0 %; i2 = 96.4 %) and females (42.2 %; 95 %CI: 34.3-50.5 %; i2 = 85.4 %). Mean/median age ranged from 59.1-67.1 years in the HPV-negative group, and from 55.7-63.5 years in the HPV-positive group. There was an overall discordance between testing by p16 (49.4 %; 95 %CI, 38.2-60.5 %; i2 = 96.2 %) and p16+ISH/PCR (44.7 %; 95 %CI, 33.5-56.2 %; i2 = 96.4 %). CONCLUSION: Overall pooled prevalence of HPV-driven OPSCC was approximately 45 %, with similar distribution among males and females. Double p16/HPV-DNA/RNA testing may be considered to increase specificity and prognostic accuracy.


Assuntos
Carcinoma de Células Escamosas , Neoplasias de Cabeça e Pescoço , Papillomaviridae , Infecções por Papillomavirus , Idoso , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/epidemiologia , Inibidor p16 de Quinase Dependente de Ciclina , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infecções por Papillomavirus/complicações , Infecções por Papillomavirus/diagnóstico , Infecções por Papillomavirus/epidemiologia , Prevalência
13.
Appl. cancer res ; 40(9): [1-7], Oct. 19, 2020. ilus, tab
Artigo em Inglês | LILACS | ID: biblio-1129401

RESUMO

Background: Lymphoedema is a common side effect after treatment for head and neck cancer. Our treatment protocol involves staging the degree of lymphoedema and then offering treatment comprising skin care, manual lymphatic drainage, simple lymphatic drainage, compression and elastic therapeutic tape. The Glasgow Benefit Inventory is a validated post-interventional questionnaire applicable to otorhinolaryngology interventions which measures changes in health status. The aim of this study was to quantify the health benefits of lymphoedema treatment using the Glasgow Inventory Benefit questionnaire, in patients with a history of treated head and neck cancer. Methods: Any patient who had undergone treatment with curative intent of a primary head and neck malignancy who had been referred for lymphoedema treatment within a 6 month period was eligible for inclusion. Patients completed a questionnaire after finishing the course of lymphoedema treatment. Results: A total of 15 patients completed the questionnaire. Ten patients (67%) demonstrated some level of improvement in quality of life, while two (13%) reported no benefit and three (20%) reported negative improvements. The average score for the total Glasgow Benefit Inventory scale was + 7.2. The greatest benefit was demonstrated with the physical benefit subscale (+ 13.1). The average general benefit score was + 9.0. Conclusions: Lymphoedema treatment involves techniques which can fairly easily be taught to patients to complete at home. In this study, there were mild improvements in patient reported quality of life using the Glasgow Benefit Inventory in the majority of patients. Clinical interest has increased in lymphoedema recently, but there is still limited information about the effectiveness of treatments and future research should look to address these issues.


Assuntos
Qualidade de Vida , Neoplasias de Cabeça e Pescoço , Linfedema , Inquéritos e Questionários
14.
Radiol Clin North Am ; 58(6): 1085-1098, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33040850

RESUMO

Fine-needle aspiration (FNA) and core biopsy of masses in the neck predominantly include samples from thyroid nodules, parathyroids and lymph nodes. The diagnostic rate of a thyroid nodule FNA improves up to 6 passes and then does not significantly change. Thyroid FNA can be performed on patients who are anticoagulated. Appropriate transducer selection is essential for visualization of the needle. Lymph node biopsies can be additionally sampled for thyroglobulin assay to improve sensitivity for detection of recurrent carcinoma. Parathyroid FNA usually involves additional estimation of parathyroid hormone concentration in needle washouts. Biopsies of the neck are simple procedures with minimal complications.


Assuntos
Biópsia por Agulha Fina/métodos , Biópsia com Agulha de Grande Calibre/métodos , Biópsia Guiada por Imagem/métodos , Neoplasias das Paratireoides/patologia , Neoplasias da Glândula Tireoide/patologia , Feminino , Neoplasias de Cabeça e Pescoço/mortalidade , Neoplasias de Cabeça e Pescoço/patologia , Neoplasias de Cabeça e Pescoço/cirurgia , Humanos , Masculino , Neoplasias das Paratireoides/diagnóstico por imagem , Melhoria de Qualidade , Sensibilidade e Especificidade , Neoplasias da Glândula Tireoide/diagnóstico por imagem , Nódulo da Glândula Tireoide/diagnóstico por imagem , Nódulo da Glândula Tireoide/patologia , Ultrassonografia Doppler/métodos
15.
Radiol Clin North Am ; 58(6): 1135-1146, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33040853

RESUMO

This article is a summary of the most up-to-date applications of radiopharmaceuticals to the diagnosis and therapy of benign and malignant diseases involving endocrine or neuroendocrine organs of the head and neck, focusing on radiotracers approved by the US Food and Drug Administration, such as I-123- and I-131-sodium iodide, F-18-fluorodeoxyglucose, Tc99m-sestamibi, as well as the more recently approved tracers Ga-68 DOTATATE and Lu-177 DOTATATE.


Assuntos
Neoplasias de Cabeça e Pescoço/diagnóstico por imagem , Imagem Molecular/métodos , Tumores Neuroendócrinos/diagnóstico por imagem , Tomografia por Emissão de Pósitrons/métodos , Compostos Radiofarmacêuticos/farmacologia , Feminino , Neoplasias de Cabeça e Pescoço/patologia , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Radioisótopos do Iodo/farmacologia , Masculino , Tumores Neuroendócrinos/patologia , Tumores Neuroendócrinos/terapia , Compostos Organometálicos/farmacologia , Sensibilidade e Especificidade , Estados Unidos , United States Food and Drug Administration
16.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1152-1155, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018191

RESUMO

The purpose of this study was to establish a methodology and technology for the development of an MRI-based radiomic signature for prognosis of overall survival (OS) in nasopharyngeal cancer from non-endemic areas. The signature was trained using 1072 features extracted from the main tumor in T1-weighted and T2-weighted images of 142 patients. A model with 2 radiomic features was obtained (RAD model). Tumor volume and a signature obtained by training the model on permuted survival data (RADperm model) were used as a reference. A 10-fold cross-validation was used to validate the signature. Harrel's C-index was used as performance metric. A statistical comparison of the RAD, RADperm and volume was performed using Wilcoxon signed rank tests. The C-index for the RAD model was higher compared to the one of the RADperm model (0.69±0.08 vs 0.47±0.05), which ensures absence of overfitting. Also, the signature obtained with the RAD model had an improved C-index compared to tumor volume alone (0.69±0.08 vs 0.65±0.06), suggesting that the radiomic signature provides additional prognostic information.


Assuntos
Neoplasias de Cabeça e Pescoço , Neoplasias Nasofaríngeas , Neoplasias de Cabeça e Pescoço/diagnóstico por imagem , Humanos , Imagem por Ressonância Magnética , Prognóstico , Estudos Retrospectivos
17.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 55(10): 789-793, 2020 Oct 09.
Artigo em Chinês | MEDLINE | ID: mdl-33045793

RESUMO

Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors, which is prone to tumor recurrence and metastasis. At present, surgery combined with radiotherapy and chemotherapy is the conventional modality for HNSCC patients, but for patients who have tumor relapse or metastasis, the treatment outcome is not ideal and the prognosis is pretty poor. Thus, to deepen the understanding of tumor mechanism will be very crucial. Post-translational modification (PTM) refer to covalent binding of small chemical molecular groups on the amino acid side chain of proteins, which is an important way of protein function regulation as well as a research hotspot of epigenetics. In recent years, it has been found that the occurrence of tumor is often accompanied by the abnormality of PTM. The abnormality plays an important role in the development of tumor and can be used as a target of tumor diagnosis and treatment. Many types of protein PTM involve in the development of HNSCC. This paper reviews the relationship between HNSCC and several major protein PTM types, including acetylation, methylation, glycosylation, in order to provide clues for the clinicians in diagnosis and treatment of HNSCC.


Assuntos
Carcinoma de Células Escamosas , Neoplasias de Cabeça e Pescoço , Carcinoma de Células Escamosas de Cabeça e Pescoço , Carcinoma de Células Escamosas/genética , Neoplasias de Cabeça e Pescoço/genética , Humanos , Recidiva Local de Neoplasia , Processamento de Proteína Pós-Traducional
18.
Rev Med Suisse ; 16(709): 1853-1859, 2020 Oct 07.
Artigo em Francês | MEDLINE | ID: mdl-33026727

RESUMO

A quarter of cutaneous melanomas occur on the head and neck. Despite close collaboration between the dermatology, oncology, pathology, nuclear medicine and otorhinolaryngology departments, the survival of patients presenting with this type of melanomas remains inferior to that of other parts of the body. The morbidity of head and neck surgery significantly alters the quality of life. Therefore, specific multidisciplinary expertise is required. We present here the specificities of ENT management.


Assuntos
Orelha , Neoplasias de Cabeça e Pescoço/terapia , Melanoma/terapia , Nariz , Faringe , Papel do Médico , Neoplasias Cutâneas/terapia , Humanos , Qualidade de Vida
19.
Stomatologiia (Mosk) ; 99(5): 96-102, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33034185

RESUMO

The article describes diagnostics and surgical treatment of a rare benign tumor (lipoblastoma) of four anatomical areas of the head and neck in an 8-months child. Diagnostic data, surgical procedure performed using microsurgical techniques and intraoperative neuromonitoring and the patient's condition in the long-term postoperative period are presented. The histological conclusion about the removal of the tumor with negative resection margins suggests favorable prognosis of the disease.


Assuntos
Neoplasias de Cabeça e Pescoço , Lipoblastoma , Transferência de Nervo , Criança , Músculos Faciais , Neoplasias de Cabeça e Pescoço/cirurgia , Humanos , Lipoblastoma/cirurgia
20.
Artigo em Chinês | MEDLINE | ID: mdl-33040497

RESUMO

Objective:To explore the correlation factors and prognosis of local recurrence of laryngeal squamous cell carcinoma. Method:The clinical data of 69 patients with local recurrence of laryngeal squamous cell carcinoma were analyzed retrospectively. The survival curve was analyzed by Kaplan-Meier method, and the survival rate was compared by chi-square test and log rank test, Cox risk regression model was used to analyze multivariate survival. Result:Patients with local recurrence of laryngeal cancer had DFS and OS at 3 years of 17.4% and 63.8%, at 5 years of 4.3% and 40.6%, respectively. The invasion of the thyroid cartilage plate is significantly related to the prognosis of the patient, and the degree of squamous cell carcinoma differentiation is an independent factor influencing the prognosis, patients with non-invasive thyroid cartilage plate and high differentiated squamous cell carcinoma have better prognosis. Conclusion:Local recurrence of laryngeal carcinoma is common among patients with moderately or poorly differentiated squamous cell carcinoma, invasion of the thyroid cartilage plate, and positive or insufficient resection margins. And the prognosis of above patients is still poor after receiving salvage surgery; comprehensive treatment and closer follow-up should be paid to these patients.


Assuntos
Carcinoma de Células Escamosas , Neoplasias de Cabeça e Pescoço , Neoplasias Laríngeas , Humanos , Recidiva Local de Neoplasia/epidemiologia , Prognóstico , Estudos Retrospectivos
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