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1.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 46(11): 1310-1314, 2021 Nov 28.
Artigo em Inglês, Chinês | MEDLINE | ID: mdl-34911868

RESUMO

Inflammatory myofibroblastoma (IMT) is a rare solid tumor, and its etiology and pathogenesis are unclear. Crohn's disease is a non-specific intestinal inflammatory disease. The clinical manifestations, laboratory examinations, and imaging examinations of IMT are not specific, making diagnosis difficult. A case of Crohn's disease combined with IMT of abdominal wall was admitted to the Department of Gastroenterology at the Third Xiangya Hospital, Central South University, on Nov. 21, 2017. This patient was admitted to our hospital because of repeated right lower abdominal pain for 4 years. A 6 cm×5 cm mass was palpated in the right lower abdomen. After completing the transanal double-balloon enteroscopy and computed tomographic enterography for the small intestinal, the cause was still unidentified. The patient underwent surgery due to an abdominal wall mass with intestinal fistula on Sept. 12, 2018 and recovered well currently. According to histopathology and immunohistochemistry, he was diagnosed with Crohn's disease combined with IMT. Up to July 2020, the patients still took azathioprine regularly, without abdominal pain, abdominal distension, and other discomfort, and the quality of his life was good.


Assuntos
Parede Abdominal , Doença de Crohn , Neoplasias de Tecido Muscular , Dor Abdominal , Parede Abdominal/cirurgia , Doença de Crohn/complicações , Humanos , Intestino Delgado , Masculino , Neoplasias de Tecido Muscular/complicações , Neoplasias de Tecido Muscular/diagnóstico por imagem , Neoplasias de Tecido Muscular/cirurgia
3.
Medicine (Baltimore) ; 100(33): e27008, 2021 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-34414993

RESUMO

RATIONALE: Rectal inflammatory myofibroblastic tumor (IMT) is an extremely rare mesenchymal tumor characterized by a mixture of spindle-shaped myofibroblasts or fibroblasts and inflammatory infiltration of lymphocytes and plasma cells. To date, only 8 cases of rectal IMT have been reported. Herein, we report an additional case of rectal IMT in a 28-year-old woman. PATIENT CONCERNS: A 28-year-old woman presented with abdominal pain and hematochezia. DIAGNOSES: Colonoscopy showed a 3.0-cm subepithelial tumor with central ulceration, covered by white exudate in the rectum. Rectal magnetic resonance imaging revealed a 4.0 × 3.0-cm-sized well-defined subepithelial tumor in the right wall of the rectum, with suspicious right perirectal fat infiltration. INTERVENTIONS: Laparoscopic anterior resection was performed. Microscopic examination of the surgical specimen revealed bland-looking spindle cells intermingled with lymphoplasma cells. Immunohistochemistry and fluorescence in situ hybridization showed anaplastic lymphoma kinase positivity and anaplastic lymphoma kinase positivity rearrangement. Rectal IMT was confirmed based on histological, immunohistochemical, and fluorescence in situ hybridization findings. The patient was doing well without evidence of tumor recurrence 1 year after the surgery. LESSONS: Rectal IMT, despite its rarity, should be considered in the differential diagnosis of rectal cancer. Second, an accurate histopathologic diagnosis and complete surgical resection can be the most important approaches to offer a chance for the cure of rectal IMT.


Assuntos
Laparoscopia/métodos , Neoplasias de Tecido Muscular/cirurgia , Reto/anormalidades , Adulto , Feminino , Humanos , Neoplasias de Tecido Muscular/fisiopatologia , Reto/fisiopatologia
4.
Breast J ; 27(9): 726-730, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34196064

RESUMO

Myofibroblastoma (MFB) is a rare benign mesenchymal tumor usually occurring in the breast parenchyma. This tumor can present as a palpable nodule or can be incidentally detected as a nonpalpable mass on routine screening mammogram. We first report a rare case of histologically proven MFB of the breast revealed by fluoro-deoxyglucose uptake on PET-CT examination in a patient with a lung nodule. Tumor exhibited an unusual morphology, being predominantly composed of polygonal, epithelioid, and deciduoid-like cells set in a myxoid stroma. The most striking feature was the multifocal presence of atypical/bizarre, mono/bi-nucleated cells that, in addition to diffuse myxoid stromal changes, were a concern of malignancy, especially on core biopsy. The final diagnosis of MFB was achieved on surgically resected specimen and, similarly to other benign soft tissue tumors (especially leiomyoma and schwannoma/neurofibroma), the term "bizarre cell MFB of the breast" is proposed to emphasize the degenerative/reactive nature of the atypia.


Assuntos
Neoplasias da Mama , Neoplasias de Tecido Muscular , Biópsia com Agulha de Grande Calibre , Mama , Neoplasias da Mama/diagnóstico por imagem , Feminino , Humanos , Neoplasias de Tecido Muscular/diagnóstico por imagem , Neoplasias de Tecido Muscular/cirurgia , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
5.
Medicine (Baltimore) ; 100(20): e25972, 2021 May 21.
Artigo em Inglês | MEDLINE | ID: mdl-34011083

RESUMO

RATIONALE: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor that is prevalent among children and adolescents. Surgery is the most important therapeutic approach for IMT and complete resection is recommended. Although 50% of IMTs show anaplastic lymphoma kinase (ALK) rearrangements, crizotinib has proven an effective therapeutic approach. However, the genetic landscape of this tumor is still not fully understood and treatment options are limited, especially in the majority of ALK-negative tumors. PATIENT CONCERNS: We describe the clinical case of a healthy 18-year-old female in whom a pulmonary nodule was incidentally detected. DIAGNOSES: Following a small increase in the size of the nodule, the patient underwent both 18FDG-PET/CT and 68Ga-PET/CT, resulting in a suspicion of bronchial hamartoma. INTERVENTIONS: The patient underwent surgery and a salivary gland-like lung tumor was diagnosed. OUTCOMES: After surgery, the patient was referred to our cancer center, where a review of the histology slides gave a final diagnosis of ALK-negative lung IMT. Given the histology, it was decided not to administer adjuvant therapy and the patient was placed in a 3-monthly follow-up program. The patient is still disease-free 2 years post-surgery. LESSONS: Although there is no standard of care for the treatment of IMT, identifying genomic alterations could help to redefine the management of patients with negative-ALK disease. Our review of the literature on IMT and other kinase fusions revealed, in addition to ALK rearrangements, the potential association of ROS1, NTRK, RET, or PDGFR beta alterations with the tumor.


Assuntos
Biomarcadores Tumorais/genética , Neoplasias Pulmonares/diagnóstico , Neoplasias de Tecido Muscular/diagnóstico , Adolescente , Quinase do Linfoma Anaplásico/genética , Broncopatias/diagnóstico , Diagnóstico Diferencial , Feminino , Hamartoma/diagnóstico , Humanos , Achados Incidentais , Pulmão/diagnóstico por imagem , Pulmão/patologia , Pulmão/cirurgia , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/imunologia , Neoplasias Pulmonares/cirurgia , Miofibroblastos/patologia , Neoplasias de Tecido Muscular/genética , Neoplasias de Tecido Muscular/imunologia , Neoplasias de Tecido Muscular/cirurgia , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
6.
Acta Orthop Traumatol Turc ; 55(2): 141-146, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33847576

RESUMO

OBJECTIVE: This study aimed to translate and cross-culturally adapt the musculoskeletal tumor society (MSTS) scoring system into Turkish and to determine the reliability and validity of the translated version for the functional evaluation of patients with musculoskeletal tumors. METHODS: A total of 36 patients (16 women, 20 men; mean age=36.6; age range=13-75 years) who underwent limb-salvage surgery owing to benign aggressive or malignant musculoskeletal tumors were included in the study. Translation and back translations of the MSTS were performed according to the published guidelines. Short form (SF) 36 physical component, Western Ontario and McMaster Universities Arthritis Index (WOMAC), disabilities of the arm, shoulder, and hand (DASH), and range of motion scale (ROMS) that were previously analyzed for Turkish validation were used for validity. Reliability of MSTS Turkish version was evaluated by calculating test-retest reliability and internal consistency. Intraclass correlation coefficient (ICC) was used to evaluate the inter-observer consistency and test-retest reliability. Alpha coefficient (Cronbach's alpha) was used to evaluate the internal consistency. RESULTS: It was observed that total MSTS score has a strong negative correlation with DASH (r=-0.689; p<0.001) and WOMAC scores (r=-0.634; p<0.001) and moderate correlation with the ROMS score (r=0.521; p<0.001). Total MSTS score also had a statistically significant strong correlation with SF-36 scores (r values ranging from 0.425 to 0.609, p<0.001). Inter and intra-observer reliability of the MSTS scale was found to be excellent (Cronbach's α=0.97 p<0.001; ICC: 0.97 (0.96-0.99; p<0.001). Unlike other subscales, statistical correlation between dexterity and hand-positioning subscales of MSTS with DASH scores was found to be insignificant (r=-0.533, p =0.061 and r=-0.336, p=0.261, respectively). CONCLUSION: The Turkish version of the MSTS scoring system seems to be a valid and reliable scale that measures the correct and desired values in the evaluation of health-related quality of life in orthopedic oncology. Reliability coefficients of the Turkish version of MSTS were determined to be strong. LEVEL OF EVIDENCE: Level II, Diagnostic Study.


Assuntos
Neoplasias Ósseas , Salvamento de Membro , Neoplasias de Tecido Muscular , Qualidade de Vida , Adulto , Neoplasias Ósseas/psicologia , Neoplasias Ósseas/cirurgia , Comparação Transcultural , Avaliação da Deficiência , Feminino , Estado Funcional , Humanos , Salvamento de Membro/métodos , Salvamento de Membro/psicologia , Salvamento de Membro/reabilitação , Masculino , Neoplasias de Tecido Muscular/psicologia , Neoplasias de Tecido Muscular/cirurgia , Psico-Oncologia/métodos , Psico-Oncologia/normas , Reprodutibilidade dos Testes , Inquéritos e Questionários , Traduções
8.
Ann R Coll Surg Engl ; 103(2): e53-e55, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33559560

RESUMO

Inflammatory myofibroblastic tumours (IMTs) are rare tumours with unpredictable biological behaviour ranging from benign to locally invasive and rarely, distant metastasis. While neurofibromatosis type 1 (NF1) may manifest with gastrointestinal soft tissue tumours, this is the first report in the literature that describes an IMT occurring in a NF1 patient who presented with intestinal obstruction. Our patient presented with intestinal obstruction secondary to an obstructing terminal ileum mesenteric tumour. En bloc bowel resection was performed, with histology revealing an IMT and an adjacent neurofibroma. The resection margins were clear and the patient was free of recurrence at six months.


Assuntos
Obstrução Intestinal/etiologia , Mesentério/patologia , Neoplasias de Tecido Muscular/diagnóstico , Neurofibromatose 1/complicações , Neoplasias Peritoneais/diagnóstico , Humanos , Obstrução Intestinal/cirurgia , Masculino , Mesentério/diagnóstico por imagem , Mesentério/imunologia , Mesentério/cirurgia , Pessoa de Meia-Idade , Neoplasias de Tecido Muscular/etiologia , Neoplasias de Tecido Muscular/imunologia , Neoplasias de Tecido Muscular/cirurgia , Neoplasias Peritoneais/etiologia , Neoplasias Peritoneais/imunologia , Neoplasias Peritoneais/cirurgia , Tomografia por Raios X , Resultado do Tratamento
10.
Orbit ; 40(1): 55-59, 2021 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31935148

RESUMO

Extra-mammary myofibroblastomas are rare benign mesenchymal neoplasms, histologically and immune-phenotypically identical to mammary myofibroblastomas. Histologically, they are characterized by the abundance of spindle cells in hyalinized collagenous stroma with positive expression of CD 34 and desmin. We present an extremely rare case of extra-mammary myofibroblastoma of the orbit in a 29-year - old male who presented with painless proptosis of the right eye, with a description of clinical, radiological, and histological findings.


Assuntos
Neoplasias de Tecido Muscular , Neoplasias Orbitárias , Adulto , Humanos , Masculino , Neoplasias de Tecido Muscular/diagnóstico por imagem , Neoplasias de Tecido Muscular/cirurgia , Neoplasias Orbitárias/diagnóstico por imagem , Neoplasias Orbitárias/cirurgia
12.
Int J Surg Pathol ; 29(3): 308-313, 2021 May.
Artigo em Inglês | MEDLINE | ID: mdl-32752900

RESUMO

Mammary-type myofibroblastoma (MFB) is a benign spindle cell tumor of the breast and soft tissue characterized by 13q14 alterations leading to loss of Rb-1 protein expression, a feature shared among spindle cell lipoma and cellular angiofibroma. In this article, we present a novel case of MFB arising in the left breast of a 70-year old man that microscopically showed an abrupt transition from classic MFB morphology to an area with cytologic atypia and mitotic activity, akin to sarcomatous transformation described in cellular angiofibromas. A thorough workup of the molecular underpinnings of both components using chromosomal microarray and next-generation sequencing platforms supported a clonal relationship. Nearly identical copy number changes, including a single copy loss of 13q14, were found in both components; in addition, the sarcomatous component harbored biallelic TP53 alterations. It is important for pathologists to recognize that sarcomatous features can occur in mammary-type MFB to arrive at the correct diagnosis.


Assuntos
Neoplasias da Mama Masculina/diagnóstico , Mama/patologia , Neoplasias Complexas Mistas/diagnóstico , Neoplasias de Tecido Muscular/diagnóstico , Idoso , Biomarcadores Tumorais/genética , Mama/cirurgia , Neoplasias da Mama Masculina/genética , Neoplasias da Mama Masculina/patologia , Neoplasias da Mama Masculina/cirurgia , Cromossomos Humanos Par 13/genética , Variações do Número de Cópias de DNA , Diagnóstico Diferencial , Humanos , Masculino , Neoplasias Complexas Mistas/patologia , Neoplasias Complexas Mistas/cirurgia , Neoplasias de Tecido Muscular/genética , Neoplasias de Tecido Muscular/patologia , Neoplasias de Tecido Muscular/cirurgia
15.
Jt Dis Relat Surg ; 31(3): 605-609, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32962596

RESUMO

Inflammatory myofibroblastic tumor (IMT) is a non-neoplastic benign lesion comprising various inflammatory cells, including myofibroblasts and vascular tissues. It is a rare tumor that sometimes shows similar signs and progression as malignant tumors. The anatomical sites of IMTs include the lungs, liver, orbit, skin, mesentery, and maxillary sinus, but they rarely occur in the limb musculoskeletal system. To our knowledge, no case of neurological symptoms caused by the tumor in the triceps brachii muscle has been reported. In this article, we report the case of a 42-year-old male patient with an IMT that grew rapidly in the triceps brachii muscle and consequently caused symptoms of ulnar nerve lesion owing to its increasing size. The patient showed no ulnar nerve lesion symptoms after undergoing wide excision and was diagnosed with anaplastic lymphoma receptor tyrosine kinase- negative IMT.


Assuntos
Neoplasias Musculares/cirurgia , Neoplasias de Tecido Muscular/cirurgia , Adulto , Quinase do Linfoma Anaplásico/metabolismo , Braço , Humanos , Masculino , Neoplasias Musculares/complicações , Neoplasias Musculares/enzimologia , Músculo Esquelético , Neoplasias de Tecido Muscular/complicações , Neoplasias de Tecido Muscular/enzimologia , Neuropatias Ulnares/etiologia
16.
Ann Diagn Pathol ; 48: 151591, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32829069

RESUMO

Myofibroblastoma is a rare type of benign myofibroblastic neoplasm in the breast. It is clinically presented as a well-circumscribed mass, usually small in size (usually less than 4.0 cm), and can mostly be cured by local excision. Rare cases of giant myofibroblastoma greater than 10 cm have been reported, but also follow a benign clinical course. Histologically, breast myofibroblastoma is featured by bland fascicles of spindle cells intermixed with thick hyalinized collagen bundles. Mast cells are frequently found within the stroma. However, a wide spectrum of morphological variants can occur in myofibroblatoma, making its diagnosis challenging sometimes. Differential diagnosis of myofibroblastoma with other spindle cell lesions in the breast, either benign or malignant, is also important in practice. In this study, we collected 15 cases of breast myofibroblastoma diagnosed in our institution during a 20 year period. The sizes of these cases range from 0.4 cm to 35.2 cm (mean is 3.7 cm). To our knowledge, the case of giant breast myofibroblastoma we presented here is the largest one reported to date. The histological examination of the cases show great morphological variations. Besides the classical type, features of cellular, collagenized, palisading, epithelioid, myxoid, myoid, solitary fibrous tumor-like are also identified in the case series. Immunohistochemical staining patterns as well as clinical features of the cases are also summarized and compared. All cases in this study show no recurrence on follow-up. In addition, cases that are important differential diagnosis for breast myofibroblastoma are also studied. Their key histological characteristics are compared with myofibroblastoma, and their immunohistochemical and molecular features are discussed.


Assuntos
Biomarcadores Tumorais/metabolismo , Neoplasias da Mama/patologia , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias de Tecido Muscular/metabolismo , Adulto , Idoso , Angiomatose/diagnóstico , Antígenos CD34/metabolismo , Biópsia , Doenças Mamárias/diagnóstico , Colágeno/metabolismo , Diagnóstico Diferencial , Feminino , Humanos , Hiperplasia/diagnóstico , Imuno-Histoquímica/métodos , Mamografia/métodos , Pessoa de Meia-Idade , Neoplasias de Tecido Muscular/cirurgia , Tumores Fibrosos Solitários/diagnóstico , Ultrassonografia/métodos , Vimentina/metabolismo
17.
Paediatr Int Child Health ; 40(4): 261-267, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-32662356

RESUMO

Inflammatory myofibroblastic tumour usually has a benign course and is very rarely associated with the heart. It can have life-threatening consequences, depending on its position or the presence of aggressive and metastatic complications. A 3-month-old boy presented with pericardial tamponade and was diagnosed with intrapericardial inflammatory myofibroblastic tumour associated with Coronavirus OC43. A large tumour attached to the left ventricle was completely removed by surgical resection and he made a full recovery. ABBREVIATIONS: ALK: anaplastic lymphoma kinase; CMV: cytomegalovirus; CRP: C-reactive protein; EB: Epstein-Barr virus; ESR: erythrocyte sedimentation rate; IM: inflammatory myofibroblastic tumour; NSAI: non-steroidal anti-inflammatory drugs; PTFE: polytetrafluoroethylene; SMA: smooth muscle actin.


Assuntos
Tamponamento Cardíaco/etiologia , Infecções por Coronavirus/complicações , Coronavirus Humano OC43 , Neoplasias Cardíacas/patologia , Neoplasias de Tecido Muscular/complicações , Infecções por Coronavirus/patologia , Neoplasias Cardíacas/cirurgia , Humanos , Lactente , Inflamação , Masculino , Miofibroblastos/patologia , Neoplasias de Tecido Muscular/patologia , Neoplasias de Tecido Muscular/cirurgia , Derrame Pericárdico/etiologia
19.
Pediatr Surg Int ; 36(8): 917-924, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32561985

RESUMO

PURPOSE: Analysis of surgical management and survival of pediatric patients with gastric tumors treated at our institution. METHODS: A retrospective study of patients with primary gastric tumors treated between 1993 and 2018 was conducted. RESULTS: Eight patients, five girls and three boys, were diagnosed with gastric tumors at an average age of 10.4 years (1 day-15.4 years). Surgical management included Billroth type I procedure in five and tumor excision in three patients. Histology revealed gastrointestinal stromal tumor (GIST) in four patients and one of each of schwannoma, myofibroblastic tumor, hamartoma and teratoma. Microscopically clear margins were reported in six patients. Repeated local recurrence occurred in three patients (2 × GIST, 1 × myofibroblastic tumors) who consequently underwent three, four and six reoperations. One of these patients had liver metastases, which were managed with ligation of the hepatic arteries. This patient was also diagnosed with a lung hamartoma, which was treated with a lobectomy. Survival rate was 100% with a median follow-up of 8.6 years (7 months-25.5 years). CONCLUSIONS: Gastric tumors are rare in children and represent a management challenge. Repeated recurrence of GISTs and myofibroblastic tumors remains frequent even after complete resection and may necessitate multiple surgeries, therefore patients require a lifelong follow-up.


Assuntos
Gastrectomia/métodos , Neoplasias Gastrointestinais/cirurgia , Hamartoma/cirurgia , Recidiva Local de Neoplasia/cirurgia , Neoplasias de Tecido Muscular/cirurgia , Neurilemoma/cirurgia , Teratoma/cirurgia , Adolescente , Criança , Pré-Escolar , Feminino , Neoplasias Gastrointestinais/patologia , Hamartoma/patologia , Humanos , Lactente , Recém-Nascido , Masculino , Neoplasias de Tecido Muscular/patologia , Neurilemoma/patologia , Estudos Retrospectivos , Análise de Sobrevida , Teratoma/patologia , Resultado do Tratamento
20.
Rev. senol. patol. mamar. (Ed. impr.) ; 33(1): 32-35, ene.-mar. 2020. ilus
Artigo em Espanhol | IBECS | ID: ibc-193244

RESUMO

El tumor miofibroblástico inflamatorio (TMI), forma parte del grupo de seudotumores inflamatorios compuesto de células fusiformes mezcladas con células plasmáticas maduras y células inflamatorias. Frecuentemente descritos en la región abdominal, pélvica, pulmonar y retroperitoneal, en pacientes pediátricos y adolescentes. La presentación en la glándula mamaria es extremadamente rara (27 casos descritos en la literatura), motivo por el cual su historia natural, recurrencia y potencial metastásico permanecen en estudio. Se trae a presentación un caso de una paciente posmenopáusica la cual fue tratada con cirugía de conservación, así como la revisión de la literatura de esta entidad


Inflammatory myofibroblastic tumour (IMT) belongs to the group of pseudo inflammatory tumours, composed of fusiform cells mixed with mature plasma cells and inflammatory cells. It is frequently described in the abdomen, pelvis, lung and retroperitoneum in paediatric and adolescent patients. Presentation in the mammary gland is extremely rare (27 cases described in the literature), which is why its natural history, recurrence and metastatic potential remain under study. We present the case of a postmenopausal patient, who was treated with conservation surgery, as well as a review of the literature of this entity


Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/cirurgia , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias de Tecido Muscular/cirurgia , Inflamação
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