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1.
Medicine (Baltimore) ; 98(52): e18414, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31876714

RESUMO

RATIONALE: Primary pulmonary inflammatory myofibroblastic tumor (IMT) with distant metastasis is extremely rare. Moreover, metastasis of pulmonary IMT to bone marrow has never been reported in previous studies. Therapeutic approaches for anaplastic lymphoma kinase (ALK)-negative pulmonary IMT with metastasis are limited. Yet there is no report on the treatment of advanced IMT cases with anti-angiogenesis drugs. PATIENT CONCERNS: We described a patient with a complaint of fatigue, with the chest computed tomography (CT) scan revealing 2 masses in bilateral lung. DIAGNOSES: The CT-guided lung biopsy examined 1 lesion in the right lung, and the post-operative pathological diagnosis of ALK-negative pulmonary IMT was recommended. However, the lung lesions were found significantly enlarged during the subsequent visit 8 months later, along with multiple metastases to the bone and abdominal cavity. A bone marrow biopsy revealed bone marrow infiltration by spindle cells. INTERVENTIONS: The patient began to take Celecoxib due to the rapid progression of IMT, however, resulting in the aggravated gastric ulcer. He stopped taking the medicine 1 month later, with no remarkable change in the lesions by CT. Apatinib was administrated instead of Celecoxib. OUTCOMES: After the 5-month treatment of Apatinib, the mass in the abdominal cavity significantly shrank and the lung lesions slightly decreased in size. With the 9-month administration of Apatinib, the lung lesions and the abdominal mass kept stable, compared with the situation in the 5-month follow-up. LESSONS: Although pulmonary IMT shows the potential of metastasis, its metastasizing to bone marrow is a highly unusual event. Apatinib is effective for pulmonary IMT, and should be taken into consideration for the treatment of inoperable pulmonary IMT patients who lack ALK rearrangement.


Assuntos
Antineoplásicos/uso terapêutico , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias de Tecido Muscular/tratamento farmacológico , Piridinas/uso terapêutico , Quinase do Linfoma Anaplásico , Humanos , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/diagnóstico por imagem , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Miofibroblastos/patologia , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias de Tecido Muscular/patologia , Tomografia Computadorizada por Raios X
2.
Acta Med Acad ; 48(1): 116-120, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31264439

RESUMO

OBJECTIVE: We report a female patient diagnosed with a leiomyosarcoma and who harbored a druggable target as identified by comprehensive genomic profiling in the course of clinical care. CASE REPORT: The patient progressed five years after curative intent surgery and adjuvant treatment. After failure of multiple lines of chemotherapy,she was enrolled in a trial of an ALK inhibitor based on comprehensive genomic profiling (CGP) identifying an TNS1-ALK fusion. CONCLUSION: In this case, identification of the ALK kinase fusion permitted enrollment in a matched mechanism driven clinical trial after exhausting standard of care treatment options. CGP raises the possibility of uterine inflammatory myofibroblastic tumor as an alternative diagnosisto leiomyosarcoma, highlighting the complementary role of CGP beyond immunohistochemical analyses.


Assuntos
Quinase do Linfoma Anaplásico/metabolismo , Genômica , Leiomiossarcoma/diagnóstico , Neoplasias de Tecido Muscular/diagnóstico , Tensinas/metabolismo , Neoplasias Uterinas/patologia , Adulto , Biomarcadores Tumorais/metabolismo , Feminino , Testes Genéticos , Humanos , Leiomiossarcoma/genética , Neoplasias de Tecido Muscular/genética , Receptores Proteína Tirosina Quinases/metabolismo , Neoplasias Uterinas/diagnóstico , Neoplasias Uterinas/genética
3.
J Cancer Res Ther ; 15(3): 725-728, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31169252

RESUMO

Inflammatory myofibroblastic tumor (IMT) is a rare tumor of unknown etiology and pathogenesis. The lesion has been recognized to occur at various sites but rarely affects the head and neck region. A 29-year-old male presented with a 13 months' history of a slow growing, painless growth in maxillary left posterior gingiva. An excisional biopsy was performed under local anesthesia. Microscopic examination revealed a compact cellular spindle cell proliferation with collagenous stroma having storiform architecture. Immunohistochemistry revealed that the tumor cells were positive for smooth muscle actin, CD-68 and negative for anaplastic lymphoma kinase. Oral IMT should be included in the differential diagnosis of localized gingival enlargement mimicking oral hyperplastic/reactive lesions.


Assuntos
Neoplasias Bucais/diagnóstico , Neoplasias de Tecido Muscular/diagnóstico , Adulto , Biomarcadores , Biópsia , Doenças da Gengiva/patologia , Humanos , Imuno-Histoquímica , Masculino , Boca/patologia , Neoplasias Bucais/cirurgia , Neoplasias de Tecido Muscular/cirurgia
4.
Ann Otol Rhinol Laryngol ; 128(11): 1078-1080, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31204488

RESUMO

OBJECTIVES: Inflammatory myofibroblastic tumor (IMT) is a rare benign lesion, especially in the pediatric age. There are several cases described in pulmonary, digestive and renal localizations, but involvement in head and neck area is infrequent. METHODS: Case report and review of the literature. RESULTS: A 1 year and 11 months old child, during 2 months had clinical signs of nasal respiratory insufficiency and epistaxis subsequently developing a purulent rhinorrhea and a sleep apnea. His pediatrician previously requested a sinus and cavum X-ray with the finding of an image compatible with an intranasal mass. Endoscopic resection was performed of the mass with further immunohistochemical analysis showing the result of a lesion compatible with IMT. CONCLUSIONS: Even though there are very few cases in scientific literature of a tumor with these characteristics in infants, IMT must be present as a differential diagnosis of intranasal masses. The role of the pathologist is essential to reach the definitive diagnosis and the performance of an early surgical treatment decreases aesthetic consequences in this pathology.


Assuntos
Endoscopia/métodos , Epistaxe/etiologia , Cavidade Nasal/patologia , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias dos Seios Paranasais/diagnóstico , Seios Paranasais/diagnóstico por imagem , Diagnóstico Diferencial , Epistaxe/diagnóstico , Humanos , Lactente , Imagem por Ressonância Magnética , Masculino , Neoplasias de Tecido Muscular/complicações , Neoplasias de Tecido Muscular/cirurgia , Neoplasias dos Seios Paranasais/complicações , Neoplasias dos Seios Paranasais/cirurgia , Tomografia Computadorizada por Raios X
5.
Tumori ; 105(6): NP1-NP3, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30900517

RESUMO

BACKGROUND: Inflammatory myofibroblastic tumor (IMT) is a rare benign cancer that can express a more aggressive phenotype related to the genetic mutation of the anaplastic lymphoma kinase receptor (ALK). Involvement of trachea is extremely rare and due to the clinical and radiologic nonspecificity, the definitive diagnosis is based on the histologic evaluation of tissue specimens. Total surgical excision is curative and chemotherapy or radiotherapy has been employed in the treatment of unresectable tumors or as adjuvant therapies. CASE PRESENTATION: The case described here is being reported because of the rare tracheal location and the atypical treatment approach used for an ALK-positive IMT. A 7-week pregnant woman voluntary interrupted pregnancy and underwent total surgical excision that resulted to have close margins. Although ALK-positive expression indicated the use of ALK inhibitors, she refused any type of adjuvant therapy that could affect ovarian function. Thus, 3D conformational external beam radiotherapy was performed with a daily dose of 180 cGy, 5 times per week, up to 45 Gy at the level of trachea. A total of 62 months of follow-up showed and no signs of disease recurrence or late radiation therapy-related toxicity. CONCLUSIONS: This report describes an extremely rare case of a tracheal IMT, underlying the key role of radiotherapy as adjuvant treatment able to definitively cure IMT, limiting systemic chemotherapy-related toxicity.


Assuntos
Neoplasias do Mediastino/diagnóstico , Neoplasias do Mediastino/radioterapia , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias de Tecido Muscular/radioterapia , Traqueia/patologia , Adulto , Biomarcadores Tumorais , Feminino , Humanos , Radioterapia Adjuvante/efeitos adversos , Radioterapia Adjuvante/métodos , Radioterapia Guiada por Imagem , Tomografia Computadorizada por Raios X , Resultado do Tratamento
6.
BMJ Case Rep ; 12(2)2019 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-30709882

RESUMO

A 30-year-old ex-smoker with a background history of childhood asthma presented with worsening shortness of breath despite receiving high doses of oral corticosteroid for pemphigus vulgaris which was diagnosed 5 years earlier. A high-resolution CT examination of the thorax reported non-specific bronchiectatic changes and revealed an incidental suprarenal mass. A subsequent CT scan confirmed a large adrenal mass with areas of necrosis and calcification. Serum renin and aldosterone, urinary catecholamine and 5-hydroxyindoleacetic acid were within normal limits. Surgical intervention was delayed due to difficulty in optimising preoperative respiratory functions. He finally underwent a midline laparotomy for removal of the tumour. Histopathological examinations revealed extrapulmonary inflammatory myofibroblastic tumour arising from the periadrenal soft-tissue, with presence of normal adrenal gland. He showed immediate improvements of his asthmatic symptoms and pemphigus vulgaris following the surgery. His oral steroid was rapidly reduced and he achieved complete remission 2 months later.


Assuntos
Neoplasias das Glândulas Suprarrenais/diagnóstico , Tosse/diagnóstico , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias das Glândulas Suprarrenais/complicações , Adulto , Doença Crônica , Tosse/etiologia , Diagnóstico Diferencial , Humanos , Masculino , Neoplasias de Tecido Muscular/complicações
7.
Int J Surg Pathol ; 27(4): 446-449, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30663457

RESUMO

The differential diagnosis of myxoid lesions in the breast is broad and includes both benign and malignant entities. Assessment is particularly challenging on core biopsy specimens. Myofibroblastoma, initially thought to be more common in the adult male breast, is being recognized with increasing frequency in the female breast. The wider anatomic distribution of mammary-type myofibroblastoma has also become known, and many new morphological variants have been described. Though focal myxoid stroma may be noted in myofibroblastomas and occasional myofibroblastomas may contain atypical cells, there have been only 3 reports in the literature of myofibroblastomas with exclusive or predominantly myxoid stroma, and 2 of these contained atypical cells. We report another case of mammary myxoid myofibroblastoma with atypical cells in a 40-year-old woman and discuss the differential diagnoses of myxoid lesions in the breast.


Assuntos
Neoplasias da Mama/diagnóstico , Mama/patologia , Neoplasias de Tecido Muscular/diagnóstico , Adulto , Biomarcadores Tumorais/análise , Biópsia com Agulha de Grande Calibre , Mama/diagnóstico por imagem , Neoplasias da Mama/patologia , Diagnóstico Diferencial , Feminino , Humanos , Mamografia , Neoplasias de Tecido Muscular/patologia , Ultrassonografia
8.
Turk Patoloji Derg ; 35(2): 151-156, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-28272683

RESUMO

Inflammatory myofibroblastic tumor is an uncommon soft tissue neoplasm of uncertain biologic behavior, and rarely reported in the stomach. An eighteen-year-old male presented with a mass in the epigastrium of three-month duration. Clinical and radiological examination suggested a gastrointestinal stromal tumor or a leiomyoma in the lesser curvature of the stomach. On the basis of histomorphological features and immunohistochemical analysis the diagnosis of inflammatory myofibroblastic tumor in the lesser curvature of the stomach was made. Inflammatory myofibroblastic tumor should be considered in the differential diagnosis of soft tissue tumors of the stomach.


Assuntos
Neoplasias de Tecido Muscular/diagnóstico , Neoplasias Gástricas/diagnóstico , Adolescente , Diagnóstico Diferencial , Endoscopia do Sistema Digestório , Humanos , Imuno-Histoquímica , Masculino , Neoplasias de Tecido Muscular/diagnóstico por imagem , Neoplasias de Tecido Muscular/patologia , Fotomicrografia , Neoplasias Gástricas/diagnóstico por imagem , Neoplasias Gástricas/patologia , Resultado do Tratamento
9.
Pol J Pathol ; 69(2): 189-194, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30351867

RESUMO

Benign spindle cell tumours of the mammary stroma comprises different lesions that show a variable degree of fibroblastic/myofibroblastic differentiation. We herein report a previously under-recognised hypocellular fibrocollagenous tumour of the breast, for which the term "fibroma" is proposed. The tumour was composed of CD34-positive bland-looking spindle cells embedded in an abundant hyalinised stroma. Fluorescence in situ hybridisation (FISH) showed 13q14 deletion in most neoplastic cells, a chromosomal alteration typically found in mammary myofibroblastoma. Based on morphological, immunohistochemical, and cytogenetic features, we suggest that fibroma belongs to the group of the benign spindle cell tumours of the mammary stroma.


Assuntos
Neoplasias da Mama/diagnóstico , Mama/patologia , Fibroma/diagnóstico , Neoplasias de Tecido Muscular/diagnóstico , Humanos , Hibridização in Situ Fluorescente , Masculino
10.
Pediatrics ; 142(5)2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-30287592

RESUMO

A 17-year-old girl presented to her primary care physician with a history of unintentional weight loss and vague sensory symptoms, including tingling of her lower extremities. She had a nonrevealing neurology workup and a largely normal rheumatology workup apart from mild elevation in her inflammatory markers. She also had a nonfocal examination apart from a posterior cervical lymph node (2 × 1 cm). Given that she was well appearing, with a nonfocal examination and only mild laboratory abnormalities, she was told to follow-up with rheumatology in 3 months. Around that time, she re-presented to her medical home for a well-child visit, during which she was noted to have continued weight loss, now amounting to 17 lb in 1 year, and marked further elevation in her inflammatory markers. Her laboratory results were also significant for a profound microcytic anemia requiring inpatient admission for blood transfusion. During her admission, she was seen by the rheumatology, gastroenterology, and oncology subspecialty teams. Despite imaging studies and extensive laboratory workup, there was no unifying diagnosis at the time of her hospital discharge. Ultimately, an outpatient imaging study revealed the etiology.


Assuntos
Biomarcadores/sangue , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias Pélvicas/diagnóstico , Adolescente , Anemia/etiologia , Diagnóstico Diferencial , Feminino , Humanos , Inflamação/patologia , Imagem por Ressonância Magnética , Neoplasias de Tecido Muscular/cirurgia , Neoplasias Pélvicas/cirurgia , Perda de Peso
12.
World J Surg Oncol ; 16(1): 161, 2018 Aug 08.
Artigo em Inglês | MEDLINE | ID: mdl-30089486

RESUMO

BACKGROUND: Inflammatory myofibroblastic tumor is an uncommon soft tissue neoplasm rarely reported in the stomach. CASE PRESENTATION: We identified a tumor highly suggestive of poorly differentiated gastric adenocarcinoma in the lesser curvature of the stomach of a 53-year-old female during screening endoscopy. Although the patient's gastric biopsy did not reveal cancer, the tumor configuration was strongly suspicious for malignancy, and we performed a gastric wedge resection using a combined laparoscopic and endoscopic method. The lesion was diagnosed as inflammatory myofibroblastic tumor based on its morphological and immunohistological features. CONCLUSIONS: Inflammatory myofibroblastic tumor should be considered in the differential diagnosis of soft tissue tumors in the stomach. We present a case of inflammatory myofibroblastic tumor safely treated with combined laparoscopic and endoscopic gastric wedge resection.


Assuntos
Neoplasias de Tecido Muscular/cirurgia , Neoplasias Gástricas/cirurgia , Feminino , Gastrectomia , Humanos , Laparoscopia , Pessoa de Meia-Idade , Neoplasias de Tecido Muscular/diagnóstico , Prognóstico , Neoplasias Gástricas/diagnóstico
13.
Korean J Gastroenterol ; 72(1): 28-32, 2018 Jul 25.
Artigo em Coreano | MEDLINE | ID: mdl-30049175

RESUMO

An inflammatory myofibroblastic tumor (IMT) is a rare disease that can occur in a variety of locations, including the lung, orbit, parotid, pleura, and stomach. Despite multiple reports in various organs, a duodenal IMT is rare with limited case reports. We encountered a case of a 49-year-old male with a duodenal IMT. The patient underwent a laparoscopic wedge resection under the impression of a duodenal mesenchymal tumor, such as gastrointestinal stromal tumor, but the final diagnosis was a duodenal IMT. The patient was treated successfully with an oral nonsteroidal anti-inflammatory drug for the residual lesions. He was free of recurrence during the 12 month follow-up period.


Assuntos
Neoplasias Duodenais/diagnóstico , Neoplasias de Tecido Muscular/diagnóstico , Actinas/metabolismo , Quinase do Linfoma Anaplásico/metabolismo , Neoplasias Duodenais/tratamento farmacológico , Neoplasias Duodenais/patologia , Endoscopia Gastrointestinal , Humanos , Masculino , Pessoa de Meia-Idade , Naproxeno/uso terapêutico , Neoplasias de Tecido Muscular/tratamento farmacológico , Neoplasias de Tecido Muscular/patologia , Tomografia Computadorizada por Raios X
14.
J Int Med Res ; 46(8): 3498-3503, 2018 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-29900760

RESUMO

Inflammatory myofibroblastic tumors (IMTs) are neoplasms with low malignant potential, and the most common tumor in the lung and orbit. Their occurrence in the uterus is rare. Approximately 50% of IMT patients have anaplastic lymphoma kinase gene ( ALK) rearrangements. Recent studies described novel fusions involving ROS1, platelet-derived growth factor receptor beta ( PDGFR-ß), and ETS translocation variant ( ETV6) genes in a subset of ALK-negative patients. We report a 44-year-old woman with anemia and uterine IMT. Ultrasonography and magnetic resonance imaging revealed a myxoid degenerative myoma-like mass, 7.4 cm in maximum diameter, on the left uterine side wall. Hysterectomy was performed as a definitive treatment. Microscopic examination revealed spindle cell proliferation with numerous lymphocytes and plasma cells. Immunohistochemically, the spindle cells were negative for ALK-1, desmin, and smooth muscle actin. The pathological diagnosis was IMT arising from the uterus. Fluorescence in situ hybridization demonstrated an ETV6-neurotrophic tyrosine kinase, receptor, type 3 gene ( NTRK3) translocation but no ALK, ROS1, or PDGFR-ß translocations. Lung and abdomen computed tomography at 31 months postoperatively revealed no disease recurrence. This association of an ETV6-NTRK3 fusion oncogene with an ALK-negative uterine IMT increases our understanding of this neoplasm, which may help the development of specific therapies.


Assuntos
Quinase do Linfoma Anaplásico/genética , Neoplasias de Tecido Muscular/genética , Proteínas de Fusão Oncogênica/genética , Neoplasias Uterinas/genética , Adulto , Quinase do Linfoma Anaplásico/metabolismo , Feminino , Humanos , Imuno-Histoquímica , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias de Tecido Muscular/cirurgia , Proteínas de Fusão Oncogênica/metabolismo , Neoplasias Uterinas/diagnóstico , Neoplasias Uterinas/cirurgia
15.
Pediatr Dev Pathol ; 21(2): 150-207, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29607758

RESUMO

This overview of mesenchymal tumors presenting in the skin and/or subcutis in children brings together the range of neoplasms and hamartomas which are seen in this age-group. It is not surprising from the perspective of the pediatric or general surgical pathologist that vascular anomalies, including true neoplasms and vascular malformations, are the common phenotypic category. Since there is considerable morphologic overlap among these lesions, clinicopathologic correlation may be more important than for many of the other mesenchymal tumors. The skin and subcutis are the most common sites of clinical presentation for the infantile myofibroma which is the most common of fibrous mesenchymal tumors in children. Several of the other mesenchymal tumors are more common adults-like dermatofibrosarcoma protuberans, but nonetheless have an important presence in children, even as a congenital neoplasm. A lipomatous tumor in a young child should be considered as a possible manifestation of an overgrowth syndrome.


Assuntos
Neoplasias da Bainha Neural/patologia , Neoplasias Cutâneas/patologia , Criança , Diagnóstico Diferencial , Fibroma/diagnóstico , Fibroma/patologia , Humanos , Lipoma/diagnóstico , Lipoma/patologia , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias de Tecido Muscular/patologia , Neoplasias da Bainha Neural/diagnóstico , Sarcoma/diagnóstico , Sarcoma/patologia , Neoplasias Cutâneas/diagnóstico , Neoplasias de Tecidos Moles/diagnóstico , Neoplasias de Tecidos Moles/patologia , Tela Subcutânea/patologia , Malformações Vasculares/diagnóstico , Malformações Vasculares/patologia , Neoplasias Vasculares/diagnóstico , Neoplasias Vasculares/patologia
18.
Int J Surg Pathol ; 26(6): 488-493, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-29552929

RESUMO

Myxoid lesions of the breast can be diagnostically challenging entities. We report 4 cases of CD34+ fibromyxoid lesion that have been previously diagnosed as "benign myxoid lesion," "nodular mucinosis," or "mammary myofibroblastoma, myxoid type" on the basis of CD34-positivity. The lesions were microscopically well circumscribed and composed of a paucicellular spindle cell proliferation in a background of myxoid stroma. No epithelial component was identified. The spindle cells showed immunohistochemical reactivity for CD34 and smooth muscle actin. Based on morphologic and immunohistochemical similarities between these cases and myxoid myofibroblastoma, we compared 4 myxoid lesions with cases of typical myofibroblastoma, utilizing retinoblastoma (Rb) antibody and fluorescent in situ hybridization for 13q14 gene rearrangement (encoding the Rb gene). The myxoid lesions showed retention of Rb protein by immunohistochemistry, whereas Rb expression was lost in cases of myofibroblastoma. We identified loss of 13q14 in 3 of 4 cases of myofibroblastoma. Notably, 13q14 gene rearrangement was not observed in any of the myxoid lesions. Our data show that there is at least a subset of CD34+ fibromyxoid lesions that, despite overlapping morphologic and immunohistochemical phenotype and proposed common histogenesis with myofibroblastomas, is genetically distinct from the latter based on Rb analysis.


Assuntos
Biomarcadores Tumorais/análise , Neoplasias da Mama Masculina/patologia , Neoplasias da Mama/patologia , Fibroma/patologia , Neoplasias de Tecido Muscular/patologia , Adulto , Antígenos CD34/análise , Mama/patologia , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/genética , Neoplasias da Mama Masculina/diagnóstico , Neoplasias da Mama Masculina/genética , Cromossomos Humanos Par 13/genética , Diagnóstico Diferencial , Feminino , Fibroma/diagnóstico , Fibroma/genética , Proteína Forkhead Box O1/genética , Rearranjo Gênico , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Neoplasias de Tecido Muscular/diagnóstico , Neoplasias de Tecido Muscular/genética , Proteínas de Ligação a Retinoblastoma/análise , Ubiquitina-Proteína Ligases/análise
19.
J Cancer Res Ther ; 14(Supplement): S257-S259, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29578184

RESUMO

Pulmonary inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor, and is considered an inflammatory pseudotumor. Here, we report of a 37-year-old woman with severe cough and stridor who was diagnosed with primary IMT of the lungs, with adenocarcinoma in situ based on the pathology in December 2012. A year later, transabdominal ultrasonography demonstrated a solid mass in the uterine wall that was initially diagnosed as a leiomyoma. However, postoperative histological examination and immunohistochemical staining revealed it as a uterine metastasis of the lung IMT. One year thereafter, the patient died of the lung tumor.


Assuntos
Neoplasias Pulmonares/patologia , Neoplasias de Tecido Muscular/patologia , Neoplasias Uterinas/diagnóstico , Neoplasias Uterinas/secundário , Adulto , Biópsia , Evolução Fatal , Feminino , Histocitoquímica , Humanos , Neoplasias Pulmonares/diagnóstico , Gradação de Tumores , Estadiamento de Neoplasias , Neoplasias de Tecido Muscular/diagnóstico , Tomografia Computadorizada por Raios X , Neoplasias Uterinas/terapia
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