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1.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 42(4): 431-435, 2020 Aug 30.
Artigo em Chinês | MEDLINE | ID: mdl-32895093

RESUMO

Objective To investigate the differences in energy spectrum CT findings between anterior mediastinal lymphoma and thymic carcinoma. Methods Twenty-two cases of anterior mediastinal lymphoma and 28 cases of thymic carcinoma confirmed by biopsy in Tangshan People's Hospital were selected.The CT values and changes of iodine content and water content in lesion sites were measured by energy spectrum analysis software.The differences between anterior mediastinal lymphoma and thymic carcinoma were compared. Results The single-energy CT value of 40-80 keV in thymus carcinoma was higher than that in anterior mediastinal lymphoma(P=0.001,P=0.037,P=0.042,P=0.034,P=0.002;P=0.016,P=0.013,P=0.018,P=0.024,P=0.012).The difference in the single-energy CT value of 90-110 keV between anterior mediastinal lymphoma and thymic carcinoma showed no statistical significance(all P>0.05).The concentrations of water in the arterial and venous stages of thymic carcinoma were significantly lower than those in the anterior mediastinal lymphoma(P=0.030,P=0.037),whereas the iodine concentrations were significantly higher(P=0.026,P=0.000). Conclusion Anterior mediastinal lymphoma and thymic carcinoma have remarkably different 40-80 keV single energy CT value and iodine concentration in arterial and venous phases,which may be helpful for the differential diagnosis of these two malignancies.


Assuntos
Linfoma , Neoplasias do Mediastino , Timoma , Neoplasias do Timo , Humanos , Linfoma/diagnóstico por imagem , Neoplasias do Mediastino/diagnóstico por imagem , Timoma/diagnóstico por imagem , Neoplasias do Timo/diagnóstico por imagem , Tomografia Computadorizada por Raios X
3.
Ann Thorac Cardiovasc Surg ; 26(5): 294-297, 2020 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-32741884

RESUMO

The Montgomery T-tube is widely used to stent airway stenotic diseases. Conventional insertion methods can sometimes fail in the case of long-distance subglottic stenosis due to the flexibility of a T-tube made of silicon, which kinks when forced against resistance. Therefore, an alternative approach can assist in the insertion of an extra-long T-tube, especially when using a long proximal limb. We report herein the case of a patient with a large mediastinal tumor caused by neurofibromatosis type 1 in which airway obstruction was avoided through the use of a novel extra-long T-tube placement technique.


Assuntos
Manuseio das Vias Aéreas/instrumentação , Neoplasias do Mediastino/complicações , Neurofibromatose 1/complicações , Estenose Traqueal/terapia , Adolescente , Feminino , Humanos , Neoplasias do Mediastino/diagnóstico por imagem , Neoplasias do Mediastino/patologia , Neurofibromatose 1/diagnóstico por imagem , Neurofibromatose 1/patologia , Estenose Traqueal/diagnóstico por imagem , Estenose Traqueal/etiologia , Resultado do Tratamento , Carga Tumoral
4.
Rev. méd. panacea ; 9(2): 90-97, mayo-ago. 2020. ilus, tab, graf
Artigo em Espanhol | LILACS, LIPECS | ID: biblio-1121163

RESUMO

Los linfomas son el conjunto de enfermedades neoplásicas de los linfocitos. El diagnóstico se fundamenta en la anamnesis, examen físico, biopsia ganglionar y estudios imagenológicos que permiten valorar la enfermedad para su estadiación y tratamiento. Objetivo: Caracterizar a partir de indicadores clínico-histo-imagenológico en casos con linfomas de localización mediastinal atendidos en el Instituto Nacional de Oncología y Radiobiología de Septiembre de 2017 a Diciembre de 2019. Materiales y métodos: Se realizó un estudio preliminar, descriptivo, prospectivo en una población de 167 casos y una muestra de 43 pacientes con linfomas de localización mediastinal. Se estudiaron las variables: sexo, edad, índice de masa corporal, síntomas y signos, tipo de tumor, subtipo histológico, estadiación por criterios de Ann-Arbor, tamaño ganglionar y localización mediastinal. Resultados: El pico de incidencia se observó entre los 25-35 años. La mayor cantidad de casos presentaron sobrepeso (n=10; 23,3%). Predominaron los Linfomas de Hodgkin (n=31; 71,8%) subtipo Esclerosis Nodular (n=22; 51,2%) con estadio IA (LH=14; 32,6%). El tamaño promedio de los ganglios fue de 25,1±17,3 mm. En todos los niveles de la anatomía mediastínica se observaron lesiones ganglionares, a predominio del mediastino superior. Otras características predominantes observadas por TC incluyeron ganglios hipodensos homogéneos (n=34; 79,07%), realce postcontraste con captación homogénea (n=24; 55,81), invasión de estructuras vecinas (n=18; 41,8%) y densidades entre 32-108 UH. Conclusiones: En la valoración de los indicadores imagenológicos por tomografía computarizada contrastada se detectan cambios morfológicos, al tomar como criterio fundamental la afectación ganglionar y el tamaño de las adenopatías en el diagnóstico, estadiamiento y reevaluación de casos con linfomas. (AU)


Lymphomas are the group of neoplastic diseases of lymphocytes. The diagnosis is based on the anamnesis, physical examination, lymph node biopsy and imaging studies that allow the disease to be assessed for its statistics and treatment. Objective: To characterize, with clinical-histological-imaging indicators, cases with lymphomas of mediastinal location treated at the National Institute of Oncology and Radiobiology from September 2017 to December 2019. Materials and methods: A preliminary, descriptive, prospective study was conducted in a population of 167 cases and a sample of 43 patients with lymphomas of mediastinal location. Variables were studied: sex, age, body mass index, symptoms and signs, tumor type, histological subtype, statistics by Ann-Arbor criteria, lymph node size and mediastinal location. Results: The peak incidence was recorded between 25-35 years. The highest number of specific cases of overweight (n = 10; 23.3%). Hodgkin lymphomas (n = 31, 71.8%), Nodular sclerosis subtype (n = 22, 51.2%) with stage IA (LH = 14, 32.6%) predominated. The average size of the nodes was 25.1 ± 17.3 mm. Nodal lesions were observed at all levels of the mediastinal anatomy, a predominance of the upper mediastinum. Other predominant features observed by CT include homogeneous hypodense nodes (n = 34; 79.07%), post-contrast enhancement with homogeneous uptake (n = 24; 55.81), invasion of neighboring structures (n = 18; 41.8%) and densities between 32-108 UH. Conclusions: Morphological changes were detected in the evaluation of the imaging indicators by contrast computed tomography, taking lymph node involvement and the size of lymphadenopathy as a fundamental criterion in the diagnosis, staging and reevaluation of cases with lymphomas. (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Tomografia Computadorizada por Raios X , Excisão de Linfonodo , Linfoma/diagnóstico por imagem , Neoplasias do Mediastino/diagnóstico por imagem , Epidemiologia Descritiva , Estudos Prospectivos
5.
Clin Nucl Med ; 45(9): e422-e424, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32657867

RESUMO

Primary neuroendocrine tumor of the mediastinum is a relatively rare entity. In metastatic/inoperable disease, therapeutic options are limited to cytotoxic chemotherapy in poorly differentiated tumors and peptide receptor radionuclide therapy in case of well-differentiated tumors. We present the case of a 52-year-old man with mediastinal atypical carcinoid (grade II) neuroendocrine tumor showing mild somatostatin receptor expression and intense FDG avidity with progressive disease on chemotherapy. Chemokine receptor targeted PET/CT with CXCR4 (Ga-CXCR4) showed tracer avidity in tumor sites higher than the physiological sites, which may pave the way for CXCR4-targeted radionuclide therapy in this subgroup of patients.


Assuntos
Tumor Carcinoide/tratamento farmacológico , Tumor Carcinoide/metabolismo , Regulação Neoplásica da Expressão Gênica , Neoplasias do Mediastino/tratamento farmacológico , Neoplasias do Mediastino/metabolismo , Receptores CXCR4/metabolismo , Tumor Carcinoide/diagnóstico por imagem , Tumor Carcinoide/patologia , Fluordesoxiglucose F18 , Humanos , Masculino , Neoplasias do Mediastino/diagnóstico por imagem , Neoplasias do Mediastino/patologia , Pessoa de Meia-Idade , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Receptores de Somatostatina/metabolismo
6.
Pediatr Blood Cancer ; 67(9): e28429, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32672885

RESUMO

Extracorporeal membrane oxygenation (ECMO) may be used in extreme circumstances for patients with a mediastinal mass and respiratory failure. We report on a young man with primary mediastinal B-cell lymphoma invading into the trachea, requiring a 40-day ECMO run who underwent fluorodeoxyglucose positron emission tomography (FDG-PET) imaging and treatment with concurrent mediastinal irradiation and continuous infusion chemotherapy while on this life-saving technology. This case illustrates that oncology patients may be managed by multidisciplinary teams for extended periods in extraordinary circumstances using multimodality therapies. Additionally, to our knowledge this is the first case to demonstrate the feasibility of FDG-PET imaging while on ECMO.


Assuntos
Quimiorradioterapia , Oxigenação por Membrana Extracorpórea , Fluordesoxiglucose F18/administração & dosagem , Linfoma de Células B , Neoplasias do Mediastino , Tomografia por Emissão de Pósitrons , Adolescente , Humanos , Linfoma de Células B/diagnóstico por imagem , Linfoma de Células B/terapia , Masculino , Neoplasias do Mediastino/diagnóstico por imagem , Neoplasias do Mediastino/terapia
8.
Pediatr. catalan ; 80(2): 65-67, abr.-jun. 2020. ilus, tab
Artigo em Catalão | IBECS | ID: ibc-195207

RESUMO

INTRODUCCIÓ: La causa principal d'insuficiència respiratòria en lactants de menys de 3 mesos és la bronquiolitis, que es pot presentar inicialment en forma d'apnees. En el diagnòstic diferencial d'apnees s'inclouen processos infecciosos, reflux gastroesofàgic, malalties neurològiques, anèmia, hipoxèmia, hipotensió, insuficiència cardíaca, alteracions metabòliques I malformacions de la via aèria, entre altres. Es presenta el cas d'un nounat amb apnees I fracàs respiratori. Durant l'estudi es diagnostica d'apnees obstructives secundàries a una massa extrínseca. CAS CLÍNIC: Nounat portat a Urgències després d'apnea amb cianosi. Inicialment se sospita bronquiolitis. Presenta nova apnea amb repercussió hemodinàmica, per la qual cosa és intubat. A la radiografia destaca atelèctasi massiva de l'hemitòrax dret. S'extuba de forma electiva, però fracassa respiratòriament I requereix nova intubació. En els controls radiològics persisteix una imatge mediastínica, que es confirma per ecografia I per tomografia axial computada toràcica. S'extirpa per cirurgia I es confirma que es tracta d'un teratoma. COMENTARIS: Dins del diagnòstic diferencial d'apnea, una de les possibilitats és una massa mediastínica. La localització de la massa pot orientarne el diagnòstic, però l'anatomia patològica és la que el confirma. En el mediastí anterior es localitzen la meitat de les masses mediastíniques, les més freqüents de les quals són els limfomes T, els tumors de cèl·lules germinals I els timomes. El mediastí és la segona localització més freqüent del teratoma extragonadal. Els teratomes immadurs s'han d'extirpar per confirmar el diagnòstic I prevenir els efectes per compressió, I pel potencial de malignització que tenen. L'alfa-fetoproteïna en els tumors productors pot permetre monitorar-los


INTRODUCCIÓN: La causa principal de insuficiencia respiratoria en lactantes menores de 3 meses es la bronquiolitis, que puede presentarse inicialmente en forma de apneas. El diagnóstico diferencial de apneas incluye procesos infecciosos, reflujo gastroesofágico, enfermedades neurológicas, anemia, hipoxemia, hipotensión, insuficiencia cardíaca, alteraciones metabólicas y malformaciones de la vía aérea, entre otros. Se presenta el caso de un neonato con apneas y fracaso respiratorio. Durante el estudio se diagnostica de apneas obstructivas secundarias a una masa extrínseca. CASO CLÍNICO: Recién nacido llevado a Urgencias después de una apnea con cianosis. Inicialmente se sospecha una bronquiolitis. Presenta nueva apnea con repercusión hemodinámica por lo que es intubado. En la radiografía destaca atelectasia masiva del hemitórax derecho. Se extuba de forma electiva, pero fracasa respiratoriamente y requiere nueva intubación. En los controles radiológicos persiste una imagen mediastínica, que se confirma por ecografía y por tomografía axial computadorizada torácica. Se extirpa por cirugía y se confirma que se trata de un teratoma. COMENTARIOS: Dentro del diagnóstico diferencial de apnea, una de las posibilidades es una masa mediastínica. La localización de la masa puede orientar su diagnóstico, pero la anatomía patológica es la que lo confirma. En el mediastino anterior se localizan la mitad de las masas mediastínicas, siendo más frecuentes los linfomas T, los tumores de células germinales y los timomas. El mediastino es la segunda localización más frecuente del teratoma extragonadal. Los teratomas inmaduros deben ser extirpados para confirmar el diagnóstico y prevenir los efectos por compresión, y por su potencial de malignización. La alfa-fetoproteína en los tumores productores puede permitir monitorizarlos


INTRODUCTION: The main cause of respiratory failure in infants under 3 months is bronchiolitis, which may initially present as apnea. The differential diagnosis of apnea includes infectious processes, gastroesophageal reflux, neurological diseases, anemia, hypoxemia, hypotension, heart failure, metabolic disorders and airway malformations, among others. We present a case of a newborn with apneic episodes and respiratory failure. During the study, obstructive apnea secondary to an extrinsic mass was diagnosed. CASE REPORT: A newborn was taken to the emergency department after an apnea with cyanosis. Bronchiolitis was initially suspected. He presented a new apneic episode with hemodynamic instability requiring intubation. The chest X-ray disclosed massive atelectasis of the right hemithorax. The baby failed an extubation attempt, and additional imaging studies showed a mediastinal mass, confirmed by ultrasound and thoracic computerized axial tomography. The mass was resected, and pathology showed teratoma. COMMENTS: A mediastinal mass should be included in the differential diagnosis of apnea. The location of the mass can guide its diagnosis, although histologic confirmation is required. Half of the mediastinal masses are located in the anterior mediastinum, with T lymphomas, germ cell tumors and thymomas being the most frequent. The mediastinum is the second most frequent location of extragonadal teratoma. Immature teratomas must be removed to confirm the diagnosis, prevent compression effects, and avoid malignant transformation. In secreting tumors, alpha-fetoprotein may facilitate monitoring


Assuntos
Humanos , Masculino , Recém-Nascido , Neoplasias do Mediastino/diagnóstico por imagem , Neoplasias do Mediastino/complicações , Teratoma/diagnóstico por imagem , Teratoma/complicações , Apneia/etiologia , Tomografia Computadorizada por Raios X , Diagnóstico Diferencial
9.
Clin Nucl Med ; 45(6): 477-479, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32366789

RESUMO

Soft tissue giant cell tumor (GCT) is rare. It usually involves the extremities. We report the case of a 37-year-old woman who was suspected of having mediastinal tumor on radiograph. Thoracic CT revealed the tumor had extensive calcification and invaded the adjacent vertebrae and spinal canal. It intensively accumulated Tc-methylene diphosphonate on bone scan. The tumor showed hypointensity on T1-weighted and mixed intensity on T2-weighted fat-saturated sagittal images. Finally, a soft tissue GCT was confirmed by pathology. The case cautions us soft tissue GCT should be in the differential diagnosis spectrum in a calcified posterior mediastinal mass with Tc-methylene diphosphonate accumulation.


Assuntos
Tumores de Células Gigantes/metabolismo , Neoplasias do Mediastino/metabolismo , Neoplasias de Tecidos Moles/metabolismo , Medronato de Tecnécio Tc 99m , Adulto , Diagnóstico Diferencial , Feminino , Tumores de Células Gigantes/diagnóstico por imagem , Tumores de Células Gigantes/patologia , Humanos , Neoplasias do Mediastino/diagnóstico por imagem , Neoplasias do Mediastino/patologia , Neoplasias de Tecidos Moles/diagnóstico por imagem , Neoplasias de Tecidos Moles/patologia , Tomografia Computadorizada por Raios X
10.
Br J Haematol ; 190(1): e1-e3, 2020 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-32379903
12.
PLoS One ; 15(4): e0231523, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32298324

RESUMO

BACKGROUND: Ultrasound-guided transthoracic core needle biopsy (US-TCNB) is a promising method for establishing the correct diagnosis of mediastinal masses. However, the existing studies in this area are scant and with small samples. PURPOSE: To evaluate the diagnostic value and the complication rate of US-TCNB, particularly large bore cutting biopsy in patients with mediastinal lesions. MATERIAL AND METHODS: This retrospective study includes 566 patients with mediastinal lesions suspicious of malignancy evaluated between March 2004 and December 2018. Inclusion criteria: 1. Patients with mediastinal lesions detected on thoracic CT scan; 2. Lesions more than 15 mm; 3. Negative histological diagnosis after bronchoscopic biopsy; 4. Normal coagulation status; 5. Cooperative patient; 6. Written informed consent. US visualization of the mediastinal lesions was successful in 308 (54.4%). In all of them, US-TCNB was performed. All patients with mediastinal lesions unsuitable for US visualization were evaluated for a CT-guided transthoracic needle biopsy (CT-TTNB), which was done if the presence of a safe trajectory was available (n = 41, 7.2%). All patients inappropriate for image-guided TTNB were referred to primary surgical diagnostic procedures (n = 217, 38.3%). RESULTS: The US-TCNB is a highly effective (accuracy 96%, sensitivity 95%) and safe tool (2.6% complications) in the diagnosis of all subgroups mediastinal lesions. It is non-inferior to CT-TTNB (90%) and comes close to the effectiveness of surgical biopsy techniques (98.4%), but is less invasive and with a lower complication rate. CONCLUSION: US-TCNB of mediastinal lesions is highly effective and safe tool which is particularly helpful in critically ill patients.


Assuntos
Biópsia por Agulha/métodos , Neoplasias do Mediastino/diagnóstico , Mediastino/patologia , Ultrassonografia de Intervenção/métodos , Biópsia por Agulha/efeitos adversos , Feminino , Humanos , Masculino , Neoplasias do Mediastino/diagnóstico por imagem , Neoplasias do Mediastino/patologia , Mediastino/diagnóstico por imagem , Pessoa de Meia-Idade , Estudos Retrospectivos , Ultrassonografia de Intervenção/efeitos adversos
14.
Radiol Med ; 125(10): 951-960, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32306201

RESUMO

OBJECTIVES: We aimed to assess the ability of radiomics, applied to not-enhanced computed tomography (CT), to differentiate mediastinal masses as thymic neoplasms vs lymphomas. METHODS: The present study was an observational retrospective trial. Inclusion criteria were pathology-proven thymic neoplasia or lymphoma with mediastinal localization, availability of CT. Exclusion criteria were age < 16 years and mediastinal lymphoma lesion < 4 cm. We selected 108 patients (M:F = 47:61, median age 48 years, range 17-79) and divided them into a training and a validation group. Radiomic features were used as predictors in linear discriminant analysis. We built different radiomic models considering segmentation software and resampling setting. Clinical variables were used as predictors to build a clinical model. Scoring metrics included sensitivity, specificity, accuracy and area under the curve (AUC). Wilcoxon paired test was used to compare the AUCs. RESULTS: Fifty-five patients were affected by thymic neoplasia and 53 by lymphoma. In the validation analysis, the best radiomics model sensitivity, specificity, accuracy and AUC resulted 76.2 ± 7.0, 77.8 ± 5.5, 76.9 ± 6.0 and 0.84 ± 0.06, respectively. In the validation analysis of the clinical model, the same metrics resulted 95.2 ± 7.0, 88.9 ± 8.9, 92.3 ± 8.5 and 0.98 ± 0.07, respectively. The AUCs of the best radiomic and the clinical model not differed. CONCLUSIONS: We developed and validated a CT-based radiomic model able to differentiate mediastinal masses on non-contrast-enhanced images, as thymic neoplasms or lymphoma. The proposed method was not affected by image postprocessing. Therefore, the present image-derived method has the potential to noninvasively support diagnosis in patients with prevascular mediastinal masses with major impact on management of asymptomatic cases.


Assuntos
Linfoma/diagnóstico por imagem , Neoplasias do Mediastino/diagnóstico por imagem , Neoplasias do Timo/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Adolescente , Adulto , Idoso , Área Sob a Curva , Confiabilidade dos Dados , Diagnóstico Diferencial , Análise Discriminante , Feminino , Humanos , Masculino , Mediastino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Estudos Retrospectivos , Sensibilidade e Especificidade , Estatísticas não Paramétricas , Adulto Jovem
15.
Anticancer Res ; 40(4): 1875-1882, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32234875

RESUMO

BACKGROUND: The method of quickly identifying metastatic mediastinal lymph nodes has become an urgent problem for lung cancer surgery. Indocyanine green (ICG) has the characteristic of being retained in or around the lymph nodes; its pharmacokinetic characteristics and optimal imaging time have not yet been elucidated. MATERIALS AND METHODS: The IVIS Lumina Imaging System was used to detect near infrared (NIR) fluorescence signals at different ICG doses, times and excitation/emission wavelengths in vitro. An artificial lymphogenous metastatic model of squamous lung carcinoma was established in 32 SCID-CB17 mice using Ma44.3 cells. An intratracheal injection of 1.25 ml/kg ICG (1.25×10-2 mg/ml) was performed, then 780 nm Ex and 845 nm Em were used to visualize ICG at four different times. The metastatic mediastinal lymph nodes and the implanted local tumor site in the left lung were confirmed with bioluminescence and hematoxylin and eosin (H&E) staining of pathological specimens. RESULTS: ICG had the strongest NIR fluorescence signal when using 780 nm Ex and 845 nm Em at 2 to 4 h after administrating 1.25×10-2 mg/ml ICG in vitro. Combined with pathological H&E examination, fluorescence imaging of ICG reflected true-positive mediastinal metastasis of the mediastinum at 0.5 h and 2 h after the injection of ICG in vivo. While true-positive local tumor growth at the site of implantation in the left lung was reflected within 4 h after the injection of ICG. CONCLUSION: ICG was able to display the metastatic mediastinal lymph nodes within 2 h after endotracheal injection in an orthotopic squamous lung carcinoma implantation model.


Assuntos
Verde de Indocianina/farmacologia , Neoplasias Pulmonares/diagnóstico por imagem , Metástase Linfática/diagnóstico por imagem , Neoplasias do Mediastino/diagnóstico por imagem , Animais , Carcinoma de Células Escamosas/diagnóstico por imagem , Carcinoma de Células Escamosas/patologia , Amarelo de Eosina-(YS)/farmacologia , Feminino , Hematoxilina/farmacologia , Xenoenxertos , Humanos , Neoplasias Pulmonares/patologia , Linfonodos/diagnóstico por imagem , Linfonodos/patologia , Metástase Linfática/patologia , Masculino , Neoplasias do Mediastino/patologia , Neoplasias do Mediastino/secundário , Mediastino/diagnóstico por imagem , Mediastino/patologia , Camundongos , Imagem Óptica
19.
Clin Nucl Med ; 45(5): 414-416, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32209882

RESUMO

Epithelioid hemangioendothelioma is a rare vascular sarcoma, and it rarely leads abnormal serum calcium. Here we presented a 61-year-old woman with suspected tumor-induced osteomalacia who underwent Ga-DOTATATE PET/CT to detect possible culprit tumor. The images showed a hypermetabolic paraspinal soft nodule in the right upper posterior mediastinum, which suggested a somatostatin receptor-positive tumor. The tumor was resected and pathologically confirmed as epithelioid hemangioendothelioma.


Assuntos
Hemangioendotelioma Epitelioide/diagnóstico por imagem , Neoplasias do Mediastino/diagnóstico por imagem , Compostos Organometálicos , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Feminino , Humanos , Pessoa de Meia-Idade
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