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1.
Adv Exp Med Biol ; 1287: 1-7, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33034022

RESUMO

The evolutionary conserved Notch pathway that first developed in metazoans and that was first discovered in fruit flies (Drosophila melanogaster) governs fundamental cell fate decisions and many other cellular key processes not only in embryonic development but also during initiation, promotion, and progression of cancer. On a first look, the Notch pathway appears remarkably simple, with its key feature representing a direct connection between an extracellular signal and transcriptional output without the need of a long chain of protein intermediaries as known from many other signaling pathways. However, on a second, closer look, this obvious simplicity exerts surprising complexity. There is no doubt that the enormous scientific progress in unraveling the functional mechanisms that underlie this complexity has recently greatly increased our knowledge about the role of Notch signaling for pathogenesis and progression of many types of cancer. Moreover, these new scientific findings have shown promise in opening new avenues for cancer prevention and therapy, although this goal is still challenging. Vol. III of the second edition of the book Notch Signaling in Embryology and Cancer, entitled Notch Signaling in Cancer, summarizes important recent developments in this fast-moving and fascinating field. Here, we give an introduction to this book and a short summary of the individual chapters that are written by leading scientists, covering the latest developments in this intriguing research area.


Assuntos
Neoplasias/prevenção & controle , Neoplasias/terapia , Receptores Notch/metabolismo , Transdução de Sinais , Animais , Diferenciação Celular , Humanos , Neoplasias/patologia
2.
Adv Exp Med Biol ; 1287: 31-46, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33034024

RESUMO

The endosomal pathway plays a pivotal role upon signal transduction in the Notch pathway. Recent work on lethal (2) giant discs (lgd) points to an additional critical role in avoiding uncontrolled ligand-independent signalling during trafficking of the Notch receptor through the endosomal pathway to the lysosome for degradation. In this chapter, we will outline the journey of Notch through the endosomal system and present an overview of the current knowledge about Lgd and its mammalian orthologs Lgd1/CC2D1b and Lgd2/CC2D1a. We will then discuss how Notch is activated in the absence of lgd function in Drosophila and ask whether there is evidence that a similar ligand-independent activation of the Notch pathway can also happen in mammals if the orthologs are inactivated.


Assuntos
Proteínas de Ligação a DNA/metabolismo , Proteínas de Drosophila/metabolismo , Neoplasias/metabolismo , Receptores Notch/metabolismo , Proteínas Repressoras/metabolismo , Transdução de Sinais , Proteínas Supressoras de Tumor/metabolismo , Animais , Endossomos/metabolismo , Humanos
3.
Adv Exp Med Biol ; 1287: 169-181, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33034032

RESUMO

The Notch signaling pathway controls normal embryonic development and tissue homeostasis of many cell types. It regulates cell proliferation, fate, differentiation, and cell death by short-range signaling between nearby cells that come in contact. The Notch pathway has also been critically involved in the pathobiology of a variety of malignancies, regulating cancer initiation and development, as well as early stages of cancer progression, by adjusting conserved cellular programs. Fibroblasts, an essential for tumor growth component of stroma, have also been affected by Notch regulation. Sequencing Notch gene mutations have been identified in a number of human tumors, revealing information on the progression of specific cancer types, such as ovarian cancer and melanoma, immune-associated tumors such as myeloid neoplasms, but especially in lymphocytic leukemia. Activation of the Notch can be either oncogenic or it may contain growth-suppressive functions, acting as a tumor suppressor in other hematopoietic cells, hepatocytes, skin, and pancreatic epithelium.


Assuntos
Progressão da Doença , Neoplasias/patologia , Receptores Notch , Transdução de Sinais , Genes Supressores de Tumor , Humanos , Neoplasias/genética , Oncogenes , Receptores Notch/metabolismo
4.
Adv Exp Med Biol ; 1287: 201-222, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33034034

RESUMO

Notch is a key evolutionary conserved pathway, which has fascinated and engaged the work of investigators in an uncountable number of biological fields, from development of metazoans to immunotherapy for cancer. The study of Notch has greatly contributed to the understanding of cancer biology and a substantial effort has been spent in designing Notch-targeting therapies. Due to its broad involvement in cancer, targeting Notch would allow to virtually modulate any aspect of the disease. However, this means that Notch-based therapies must be highly specific to avoid off-target effects. This review will present the newest mechanistic and therapeutic advances in the Notch field and discuss the promises and challenges of this constantly evolving field.


Assuntos
Imunoterapia , Terapia de Alvo Molecular , Neoplasias/terapia , Receptores Notch/antagonistas & inibidores , Humanos , Neoplasias/imunologia , Fenótipo , Receptores Notch/metabolismo
5.
Texto & contexto enferm ; 29: e20180451, Jan.-Dec. 2020. tab
Artigo em Inglês | LILACS, BDENF - Enfermagem | ID: biblio-1101983

RESUMO

ABSTRACT Objective: to analyze the relationship between the characteristics of patients in cancer treatment, their family caregivers, the care provided with the overload, as well as between overload and the care skills. Method: a cross-sectional study conducted at the chemotherapy and radiotherapy services of a university hospital in Rio Grande do Sul (Brazil) from March to August 2017, with 132 family caregivers of patients in cancer treatment. Data was collected by an instrument that characterizes patients, caregivers and care (the Brazilian version of the Caring Ability Inventory) and the Zarit Overload Scale. The following coefficients were used: Spearman correlation, Mann-Whitney or Kruskal-Wallis. Results: there was a significant relationship between the total overload and the patient's level of dependence (p=0.021) and help from others (p=0.009). The "care impact" factor was significantly related with the patient's level of dependence (p=0.006), the caregiver's gender (p=0.035) and the care help (p=0.043). Regarding the "perception of self-efficacy" factor, there was a significant relationship involving the caregiver's age (p=0.036) and, in the "caregiver expectation" factor, a significant relationship was observed with the care help (p=0.002). There was a significant and negative correlation between the total care skill and the overload factor related to interpersonal relationship (p=0.035); and between the "courage" dimension and the "perception of self-efficacy" (p=0.032) and "interpersonal relationship" (p=0.008) factors. Conclusion: the characteristics of the patient, the caregiver and the care provided influence the overload of the family caregiver, and this overload, in turn, interferes with the care skills. These results should be considered when planning interventions that aim to guide and prepare family caregivers for home care.


RESUMEN Objetivo: analizar la asociación de las características de pacientes en tratamiento oncológico, las de sus cuidadores familiares y las de los cuidados prestados con la sobrecarga, y entre esta última y la habilidade de cuidado. Método: estudio transversal desarrollado en los servicios de quimioterapia y radioterapia de un hospital universitario de Rio Grande do Sul (Brasil), entre marzo y agosto de 2017, con 132 cuidadores familiares de pacientes en tratamiento oncológico. Los datos se recolectaron por medio de un instrumento para caracterizar a los pacientes, a los cuidadores y a los cuidados, la versión brasileña del Caring Ability Inventory, y por medio de la Escala de Sobrecarga de Zarit. Se utilizaron los siguientes coeficientes: correlación de Spearman, Mann-Whitney o Kruskal-Wallis. Resultados: se observó una asociación significativa de la sobrecarga total con el grado de dependencia del paciente (p=0,021) y la ayuda de terceros para prestar los cuidados (p=0,009). El factor "impacto de los cuidados" se asoció de manera significativa con el grado de dependencia del paciente (p=0,006), el sexo del cuidador (p=0,035) y la ayuda para ofrecer los cuidados (p=0,043). En el factor "percepción de la autoeficiencia" se registró una asociación significativa con la edad del cuidador (p=0,036) y en el factor "expectativa con respecto a ofrecer los cuidados" se observó una asociación significativa con la ayuda para ofrecerlos (p=0,002). Se registró una asociación significativa y negativa entre la habilidad total de los cuidados y el factor de la sobrecarga relacionado con la relación interpersonal (p=0,035); y de la dimensión "coraje" y los factores "percepción de la autoeficiencia" (p=0,032) y relación interpersonal (p=0,008). Conclusión: las características del paciente, del cuidador y de los cuidados prestados influyen sobre la sobrecarga del cuidador familiar; y dicha sobrecarga, a su vez, interfiere en la habilidade de cuidar. Estos resultados deben ser considerados al planificar intervenciones destinadas a orientar y preparar a los cuidadores familiares para prestar cuidados domiciliarios.


RESUMO Objetivo: analisar a associação entre as características de pacientes em tratamento oncológico, de seus cuidadores familiares e do cuidado prestado com a sobrecarga, e desta com a habilidade de cuidado. Método: estudo transversal desenvolvido nos serviços de quimioterapia e radioterapia de um hospital universitário do Rio Grande do Sul (Brasil), no período de março a agosto de 2017, com 132 cuidadores familiares de pacientes em tratamento oncológico. Os dados foram coletados por instrumento de caracterização dos pacientes, dos cuidadores e do cuidado, - versão brasileira do Caring Ability Inventory e a Escala de Sobrecarga de Zarit. Os seguintes coeficientes foram utilizados: correlação de Spearman, Mann-Whitney ou Kruskal-Wallis. Resultados: foi observada associação significativa da sobrecarga total com o grau de dependência do paciente (p=0,021) e auxílio de terceiros para o cuidado (p=0,009). O fator impacto de cuidado associou-se de modo significativo com o grau de dependência do paciente (p=0,006), sexo do cuidador (p=0,035) e auxílio para o cuidado (p= 0,043). No fator percepção de autoeficácia houve associação significativa com a idade do cuidador (p=0,036) e, no fator expectativa face ao cuidar, observou-se associação significativa com o auxílio para o cuidado (p=0,002). Houve correlação significativa e negativa entre a habilidade de cuidado total e o fator da sobrecarga relacionado à relação interpessoal (p=0,035); e da dimensão coragem e os fatores percepção de autoeficácia (p=0,032) e relação interpessoal (p=0,008). Conclusão: as características do paciente, do cuidador e do cuidado prestado influenciam na sobrecarga do cuidador familiar e esta, por sua vez, interfere na habilidade de cuidado. Esses resultados devem ser considerados no planejamento de intervenções que visem orientar e preparar os cuidadores familiares para cuidados domiciliares.


Assuntos
Humanos , Família , Enfermagem , Cuidadores , Assistência Domiciliar , Neoplasias , Estudos Transversais , Serviços de Assistência Domiciliar
6.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde | ID: lis-47917

RESUMO

Infográficos sobre alimentos e hábitos saudáveis também serão divulgados pelo Instituto durante semana comemorativa do Dia Mundial da Alimentação


Assuntos
Neoplasias/prevenção & controle , Estilo de Vida Saudável , Atividade Motora
7.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde | ID: lis-47915

RESUMO

Prevenção do câncer é a ação tomada para reduzir a chance de contrair a doença. Segundo estimativas do INCA, para o triênio 2020/2022, cerca de 625 mil de pessoas serão diagnosticadas com câncer no Brasil, em cada um desses anos


Assuntos
Neoplasias/prevenção & controle
8.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde | ID: lis-47912

RESUMO

Evento online reuniu líderes e mostrou os desafios do setor no Brasil durante e pós-coronavírus


Assuntos
Neoplasias , Infecções por Coronavirus , Congresso
9.
Environ Monit Assess ; 192(11): 680, 2020 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-33025180

RESUMO

In this study, the activities of 40K, 210Pb, 232Th, 234U, 235U, and 238U in size-segregated particulate matter (PM) were measured in the Singrauli Coalfield, India. Different isotopic compositions were found relative to natural uranium ratios. The radioactivity concentration ratios in different PM sizes [PM2.5, PM10, and suspended particulate matter (SPM)] suggested that anthropogenic sources affected the uranium isotopic compositions in the area. A different isotopic composition from the natural uranium composition was found. The correlation coefficients between the measured isotopes (40K, 210Pb, 232Th, 234U, 235U, and 238U) and meteorological factors were calculated. PM emissions were affected by the meteorological conditions, which in turn, influenced the U and Th concentrations in PM. The 232Th/238U activity ratio in particulate matter was between 0.20 and 1.54 with an average value of 0.9 ± 0.5, 0.2 to 1.1 (0.8 ± 0.7), and 0.2 to 1.2 with an average value of 0.8 ± 0.8 in PM2.5, PM10, and SPM, respectively. These range were quite different from the average crustal ratio of 3.5, indicating that the 238U concentrations were elevated in this region relative to Th. However, compared with Th, the dose contribution of U to the public was negligible. The average effective dose in public owing to inhalation of natural radioactive 40K, 210Pb, 232Th, and 234U, 235U, and 238U in the atmosphere was between 0.03 and 327 nSv year-1. These doses associated with the inhalation of particulate matter were lower than world airborne reference value as reported by UNSCEAR (2000a). Graphical abstract.


Assuntos
Neoplasias , Material Particulado , Monitoramento Ambiental , Humanos , Índia , Material Particulado/análise , Radioisótopos
10.
Discov Med ; 29(157): 129-137, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33002409

RESUMO

Sepsis is a life-threatening clinical condition demanding accurate and rapid diagnosis of the culprit pathogen, thereby to improve prognosis. Pathogen determination through blood culture is the gold standard for diagnosis but has limitations due to low sensitivity. Recently, circulating DNAs derived from pathogenic organisms were found in the plasma of patients with sepsis and were further proved to be more sensitive biomarkers for the diagnosis of the pathogen origin in sepsis. However, the fundamental molecular characteristics of circulating DNA in patients with sepsis remain unclear. Here, we used specific PCR and Sanger sequencing to verify the microbiology culture results via the corresponding plasma circulating DNA. We analyzed the composition and molecular characteristics of circulating DNA in septic patients using next-generation sequencing technology. We showed the presence of pathogen-derived circulating DNA in the plasma of patients with sepsis. The sizes of circulating DNA fragments derived from pathogenic bacteria showed a skewed unimodal distribution, while those derived from host cells showed a normal unimodal distribution. Lengths of fragments at peak concentration for both origins ranged from 150 bp to 200 bp, and reads mapping to pathogenic bacteria genome distributed uniformly on the reference. Our findings have improved our understanding of microbial circulating DNA in patients with sepsis as a potential methodology for the accurate diagnosis of sepsis, especially in light of an urgent need for such a diagnosis associated with the COVID-19 infection.


Assuntos
Infecções Bacterianas/microbiologia , Ácidos Nucleicos Livres/sangue , DNA Bacteriano/sangue , Sepse/microbiologia , Adulto , Idoso , Infecções Bacterianas/complicações , Infecções Bacterianas/diagnóstico , Betacoronavirus , Ácidos Nucleicos Livres/análise , Técnicas de Laboratório Clínico , Infecções por Coronavirus/diagnóstico , Técnicas de Cultura , DNA Bacteriano/análise , Feminino , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias/complicações , Pandemias , Pneumonia Viral , Reação em Cadeia da Polimerase , Sepse/complicações , Sepse/diagnóstico , Análise de Sequência de DNA
14.
BMC Bioinformatics ; 21(Suppl 14): 364, 2020 Sep 30.
Artigo em Inglês | MEDLINE | ID: mdl-32998700

RESUMO

BACKGROUND: Machine learning has been utilized to predict cancer drug response from multi-omics data generated from sensitivities of cancer cell lines to different therapeutic compounds. Here, we build machine learning models using gene expression data from patients' primary tumor tissues to predict whether a patient will respond positively or negatively to two chemotherapeutics: 5-Fluorouracil and Gemcitabine. RESULTS: We focused on 5-Fluorouracil and Gemcitabine because based on our exclusion criteria, they provide the largest numbers of patients within TCGA. Normalized gene expression data were clustered and used as the input features for the study. We used matching clinical trial data to ascertain the response of these patients via multiple classification methods. Multiple clustering and classification methods were compared for prediction accuracy of drug response. Clara and random forest were found to be the best clustering and classification methods, respectively. The results show our models predict with up to 86% accuracy; despite the study's limitation of sample size. We also found the genes most informative for predicting drug response were enriched in well-known cancer signaling pathways and highlighted their potential significance in chemotherapy prognosis. CONCLUSIONS: Primary tumor gene expression is a good predictor of cancer drug response. Investment in larger datasets containing both patient gene expression and drug response is needed to support future work of machine learning models. Ultimately, such predictive models may aid oncologists with making critical treatment decisions.


Assuntos
Antineoplásicos/farmacologia , Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos , Aprendizado de Máquina , Antineoplásicos/uso terapêutico , Área Sob a Curva , Análise por Conglomerados , Bases de Dados Genéticas , Desoxicitidina/análogos & derivados , Desoxicitidina/farmacologia , Desoxicitidina/uso terapêutico , Fluoruracila/uso terapêutico , Humanos , Neoplasias/tratamento farmacológico , Curva ROC
15.
Yakugaku Zasshi ; 140(10): 1243-1249, 2020.
Artigo em Japonês | MEDLINE | ID: mdl-32999203

RESUMO

Here the author describes the tumor-selective delivery of a fluorescence photosensitizing agent and an antitumor agent, based on the polymer effect of an N-(2-hydroxypropyl)methacrylamide (HPMA) based copolymer, by utilizing the enhanced permeability and retention (EPR) effect seen in solid tumors. Firstly, the tumor distribution of the photosensitizer, zinc-protoporphyrin IX (ZnPP), was significantly increased by conjugation with the HPMA polymer (P-ZnPP). The P-ZnPP suppressed tumor growth by local generation of cytotoxic singlet oxygen, and the tumor tissue was visualized by fluorescence upon light irradiation. Subsequently, a two-step mechanism for tumor selectivity was observed for the cytotoxic anthracycline, pirarubicin (THP), which conjugated the HPMA-based copolymer via a hydrazone bond (P-THP). The EPR-dependent accumulation of P-THP and the tumor-selective release of THP in the tumor tissues led to highly tumor-selective toxicity. Rapid cell uptake of THP compared to other anthracyclines, and deeper P-THP penetration of the tumor cell spheroid were attributed to the superior antitumor activity of P-THP. The molecular weight of P-THP affected its antitumor activity; oligomeric P-THP derivatives with higher molecular weights, DP-THP and SP-THP, showed even higher antitumor activity. P-THP was effective for both implanted tumor and autochthonous tumor models. These results indicate that nano-sized anticancer drugs based on polymer effect are promising clinical therapeutics.


Assuntos
Antineoplásicos , Sistemas de Liberação de Medicamentos , Desenvolvimento de Medicamentos/métodos , Neoplasias/tratamento farmacológico , Neoplasias/metabolismo , Fármacos Fotossensibilizantes , Polímeros , Protoporfirinas , Animais , Antraciclinas/química , Antraciclinas/metabolismo , Antineoplásicos/química , Antineoplásicos/metabolismo , Doxorrubicina/análogos & derivados , Doxorrubicina/química , Doxorrubicina/metabolismo , Humanos , Concentração de Íons de Hidrogênio , Metacrilatos/química , Terapia de Alvo Molecular , Peso Molecular , Neoplasias/patologia , Fármacos Fotossensibilizantes/química , Fármacos Fotossensibilizantes/metabolismo , Protoporfirinas/química , Protoporfirinas/metabolismo
16.
Hum Genomics ; 14(1): 35, 2020 10 02.
Artigo em Inglês | MEDLINE | ID: mdl-33008459

RESUMO

Precision medicine aims to empower clinicians to predict the most appropriate course of action for patients with complex diseases like cancer, diabetes, cardiomyopathy, and COVID-19. With a progressive interpretation of the clinical, molecular, and genomic factors at play in diseases, more effective and personalized medical treatments are anticipated for many disorders. Understanding patient's metabolomics and genetic make-up in conjunction with clinical data will significantly lead to determining predisposition, diagnostic, prognostic, and predictive biomarkers and paths ultimately providing optimal and personalized care for diverse, and targeted chronic and acute diseases. In clinical settings, we need to timely model clinical and multi-omics data to find statistical patterns across millions of features to identify underlying biologic pathways, modifiable risk factors, and actionable information that support early detection and prevention of complex disorders, and development of new therapies for better patient care. It is important to calculate quantitative phenotype measurements, evaluate variants in unique genes and interpret using ACMG guidelines, find frequency of pathogenic and likely pathogenic variants without disease indicators, and observe autosomal recessive carriers with a phenotype manifestation in metabolome. Next, ensuring security to reconcile noise, we need to build and train machine-learning prognostic models to meaningfully process multisource heterogeneous data to identify high-risk rare variants and make medically relevant predictions. The goal, today, is to facilitate implementation of mainstream precision medicine to improve the traditional symptom-driven practice of medicine, and allow earlier interventions using predictive diagnostics and tailoring better-personalized treatments. We strongly recommend automated implementation of cutting-edge technologies, utilizing machine learning (ML) and artificial intelligence (AI) approaches for the multimodal data aggregation, multifactor examination, development of knowledgebase of clinical predictors for decision support, and best strategies for dealing with relevant ethical issues.


Assuntos
Infecções por Coronavirus/genética , Diabetes Mellitus/genética , Neoplasias/genética , Pneumonia Viral/genética , Medicina de Precisão/tendências , Cardiomiopatias , Infecções por Coronavirus/epidemiologia , Análise de Dados , Diabetes Mellitus/epidemiologia , Genômica/tendências , Humanos , Metabolômica/tendências , Neoplasias/epidemiologia , Pandemias , Pneumonia Viral/epidemiologia , Proteômica/tendências
18.
JCO Glob Oncol ; 6: 1494-1509, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-33017179

RESUMO

PURPOSE: The coronavirus disease 2019 (COVID-19) pandemic has had a global impact, and Singapore has seen 33,000 confirmed cases. Patients with cancer, their caregivers, and health care workers (HCWs) need to balance the challenges associated with COVID-19 while ensuring that cancer care is not compromised. This study aimed to evaluate the psychological effect of COVID-19 on these groups and the prevalence of burnout among HCWs. METHODS: A cross-sectional survey of patients, caregivers, and HCWs at the National Cancer Centre Singapore was performed over 17 days during the lockdown. The Generalized Anxiety Disorder-7 and Maslach Burnout Inventory were used to assess for anxiety and burnout, respectively. Self-reported fears related to COVID-19 were collected. RESULTS: A total of 624 patients, 408 caregivers, and 421 HCWs participated in the study, with a response rate of 84%, 88%, and 92% respectively. Sixty-six percent of patients, 72.8% of caregivers, and 41.6% of HCWs reported a high level of fear from COVID-19. The top concern of patients was the wide community spread of COVID-19. Caregivers were primarily worried about patients dying alone. HCWs were most worried about the relatively mild symptoms of COVID-19. The prevalence of anxiety was 19.1%, 22.5%, and 14.0% for patients, caregivers, and HCWs, respectively. Patients who were nongraduates and married, and caregivers who were married were more anxious. The prevalence of burnout in HCWs was 43.5%, with more anxious and fearful HCWs reporting higher burnout rates. CONCLUSION: Fears and anxiety related to COVID-19 are high. Burnout among HCWs is similar to rates reported prepandemic. An individualized approach to target the specific fears of each group will be crucial to maintain the well-being of these vulnerable groups and prevent burnout of HCWs.


Assuntos
Ansiedade/epidemiologia , Esgotamento Profissional/epidemiologia , Cuidadores/psicologia , Infecções por Coronavirus/psicologia , Neoplasias/psicologia , Pneumonia Viral/psicologia , Adulto , Idoso , Ansiedade/diagnóstico , Ansiedade/psicologia , Betacoronavirus/patogenicidade , Esgotamento Profissional/diagnóstico , Esgotamento Profissional/psicologia , Institutos de Câncer/organização & administração , Institutos de Câncer/normas , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/prevenção & controle , Infecções por Coronavirus/transmissão , Estudos Transversais , Medo/psicologia , Feminino , Pessoal de Saúde/psicologia , Acesso aos Serviços de Saúde/organização & administração , Acesso aos Serviços de Saúde/normas , Humanos , Controle de Infecções/normas , Transmissão de Doença Infecciosa do Paciente para o Profissional/prevenção & controle , Transmissão de Doença Infecciosa do Profissional para o Paciente/prevenção & controle , Masculino , Oncologia/organização & administração , Oncologia/normas , Pessoa de Meia-Idade , Neoplasias/terapia , Pandemias/prevenção & controle , Pneumonia Viral/epidemiologia , Pneumonia Viral/prevenção & controle , Pneumonia Viral/transmissão , Prevalência , Singapura/epidemiologia , Carga de Trabalho/psicologia
19.
Oncol Nurs Forum ; 47(6): 629-630, 2020 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-33063785

RESUMO

Infusion of antineoplastic medications in nontraditional settings, including the home, is not a new concept. However, the emergence of the novel coronavirus, COVID-19, has accelerated conversations around ensuring that patients with cancer can continue timely cancer treatment regimens while minimizing their risk of COVID-19 exposure and infection. Administration of antineoplastics through home infusion has been offered as a potential solution and continues to gain momentum among healthcare facilities and third-party payers.


Assuntos
Antineoplásicos/administração & dosagem , Terapia por Infusões no Domicílio/enfermagem , Neoplasias/tratamento farmacológico , Infecções por Coronavirus/epidemiologia , Humanos , Enfermagem Oncológica , Pandemias , Pneumonia Viral/epidemiologia , Risco , Sociedades de Enfermagem , Estados Unidos/epidemiologia
20.
Rev Prat ; 70(6): 594-598, 2020 Jun.
Artigo em Francês | MEDLINE | ID: mdl-33058596

RESUMO

New in radiotherapy of solid tumors. The new irradiation techniques integrate the latest technological developments in medical imaging and computer science, dosimetry, and linacs into the treatment procedure. They raise new hopes for the treatment of solid tumor pathologies. Three techniques seem particularly promising: intensity modulated radiotherapy, respiratory gating radiotherapy, and stereotactic radiotherapy. The emergence of artificial intelligence, and particularly its applications in the field of imaging, opens up a new field of research. The purpose of these different innovations is to achieve very high precision radiotherapy, which makes it possible to better adapt the radiation fields to the tumor and thus protect the critical organs.


Assuntos
Neoplasias , Radiocirurgia , Radioterapia de Intensidade Modulada , Inteligência Artificial , Humanos , Neoplasias/radioterapia
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