Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 901
Filtrar
1.
Pediatr Blood Cancer ; 67 Suppl 3: e28324, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32614139

RESUMO

Traditional and complementary medicine (T&CM) strategies are commonly used by pediatric cancer patients. Nutritional approaches to T&CM include bioactive compounds, supplements, and herbs as well as dietary approaches. Pediatric cancer patients and their families commonly request and use nutritional T&CM strategies. We review the potential risks and benefits of nutritional T&CM use in pediatric cancer care and provide an overview of some commonly used and requested supplements, including probiotics, antioxidants, cannabinoids, vitamins, turmeric, mistletoe, Carica papaya, and others. We also discuss the role of specific diets such as the ketogenic diet, caloric restriction diets, whole-food diets, and immune modulating diets. There is a growing body of evidence to support the use of some T&CM agents for the supportive care of children with cancer. However, further study is needed into these agents and approaches. Open communication with families about T&CM use is critical.


Assuntos
Neoplasias/terapia , Apoio Nutricional/métodos , Cuidados Paliativos/métodos , Criança , Suplementos Nutricionais , Humanos , Neoplasias/dietoterapia , Pediatria/métodos , Prebióticos/administração & dosagem , Probióticos/administração & dosagem , Ensaios Clínicos Controlados Aleatórios como Assunto , Vitaminas/administração & dosagem
2.
Pediatr Blood Cancer ; 67 Suppl 3: e28378, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32614140

RESUMO

Nutrition therapy is a therapeutic approach to treating medical conditions and symptoms via diet, which can be done by oral, enteral or parenteral routes. It is desirable to include nutritional interventions as a standard of care in pediatric cancer units (PCUs) at all levels of care. The interventions are dependent on available resources and personnel across all clinical settings. Enteral nutrition is easy, inexpensive, uses the gastrointestinal tract, maintains gut mucosal integrity, and allows for individualized nutritional strategies. This narrative review describes enteral nutritional interventions for children undergoing cancer treatment and is aimed at PCUs of all levels of care located in a low- and middle-income country.


Assuntos
Nutrição Enteral/métodos , Desnutrição/terapia , Neoplasias/dietoterapia , Neoplasias/tratamento farmacológico , Adolescente , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Criança , Nutrição Enteral/normas , Humanos , Masculino , Desnutrição/prevenção & controle
3.
Adv Exp Med Biol ; 1259: 125-153, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32578175

RESUMO

Patients with cancer frequently overexpress inflammatory cytokines with an associated neutrophilia both of which may be downregulated by diets with high omega-3 polyunsaturated fatty acids (ω-3 PUFA). The anti-inflammatory activity of dietary ω-3 PUFA has been suggested to have anticancer properties and to improve survival of cancer patients. Currently, the majority of dietary research efforts do not differentiate between obesity and dietary fatty acid consumption as mediators of inflammatory cell expansion and tumor microenvironmental infiltration, initiation, and progression. In this chapter, we discuss the relationships between dietary lipids, inflammation, neoplasia and strategies to regulate these relationships. We posit that dietary composition, notably the ratio of ω-3 vs. ω-6 PUFA, regulates tumor initiation and progression and the frequency and sites of metastasis that, together, impact overall survival (OS). We focus on three broad topics: first, the role of dietary lipids in chronic inflammation and tumor initiation, progression, and regression; second, lipid mediators linking inflammation and cancer; and third, dietary lipid regulation of murine and human tumor initiation, progression, and metastasis.


Assuntos
Ácidos Graxos Ômega-3/farmacologia , Ácidos Graxos Ômega-3/uso terapêutico , Neoplasias , Microambiente Tumoral/efeitos dos fármacos , Animais , Dieta , Ácidos Graxos Ômega-6/farmacologia , Humanos , Inflamação/dietoterapia , Inflamação/patologia , Neoplasias/dietoterapia , Neoplasias/patologia
4.
Nature ; 579(7800): 507-517, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32214253

RESUMO

Tumours depend on nutrients supplied by the host for their growth and survival. Modifications to the host's diet can change nutrient availability in the tumour microenvironment, which might represent a promising strategy for inhibiting tumour growth. Dietary modifications can limit tumour-specific nutritional requirements, alter certain nutrients that target the metabolic vulnerabilities of the tumour, or enhance the cytotoxicity of anti-cancer drugs. Recent reports have suggested that modification of several nutrients in the diet can alter the efficacy of cancer therapies, and some of the newest developments in this quickly expanding field are reviewed here. The results discussed indicate that the dietary habits and nutritional state of a patient must be taken into account during cancer research and therapy.


Assuntos
Dieta , Neoplasias/dietoterapia , Neoplasias/terapia , Estado Nutricional , Aminoácidos/deficiência , Aminoácidos/metabolismo , Animais , Suplementos Nutricionais , Jejum/fisiologia , Ácidos Graxos/metabolismo , Ácido Fólico/metabolismo , Frutose/deficiência , Frutose/metabolismo , Glucose/metabolismo , Humanos , Neoplasias/metabolismo , Neoplasias/patologia
5.
Pediatr Blood Cancer ; 67 Suppl 3: e28117, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32134218

RESUMO

Adequate and appropriate nutrition is essential for growth and development in children; all put at risk in those with cancer. Overnutrition and undernutrition at diagnosis raise the risk of increased morbidity and mortality during therapy and beyond. All treatment modalities can jeopardize nutritional status with potentially adverse effects on clinical outcomes. Accurate assessment of nutritional status and nutrient balance is essential, with remedial interventions delivered promptly when required. Children with cancer in low- and middle-income countries (LMICs) are especially disadvantaged with concomitant challenges in the provision of nutritional support. Cost-effective advances in the form of ready-to-use therapeutic foods (RUTF) may offer solutions. Studies in LMICs have defined a critical role for the gut microbiome in the causation of undernutrition in children and have demonstrated a beneficial effect of selected RUTF in redressing the imbalanced microbiota and improving nutritional status. Challenges in high-income countries relate both to concerns about the potential disadvantage of preexisting obesity in those newly diagnosed and to undernutrition identified at diagnosis and during treatment. Much remains to be understood but the prospects are bright for offsetting malnutrition in children with cancer, resulting in enhanced opportunity for healthy survival.


Assuntos
Transtornos da Nutrição Infantil/dietoterapia , Transtornos da Nutrição Infantil/metabolismo , Neoplasias/dietoterapia , Neoplasias/metabolismo , Estado Nutricional , Fatores Etários , Criança , Transtornos da Nutrição Infantil/mortalidade , Transtornos da Nutrição Infantil/patologia , Humanos , Neoplasias/mortalidade , Neoplasias/patologia , Apoio Nutricional , Ensaios Clínicos Controlados Aleatórios como Assunto
6.
Pediatr Blood Cancer ; 67 Suppl 3: e28213, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32096351

RESUMO

It is indisputable that adequate and appropriate nutrition is fundamental to the health, growth, and development of infants, children, and adolescents, including those with cancer. Nutrition has a role in most of the accepted components of the cancer control spectrum, from prevention through to palliation. The science of nutrigenomics, nutrigenetics, and bioactive foods (phytochemicals), and how nutrition affects cancer biology and cancer treatment, is growing. Nutritional epigenetics is giving us an understanding that there are possible primary prevention strategies for pediatric cancers, especially during conception and pregnancy, which need to be studied. Primary prevention of cancer in adults, such as colorectal cancer, should commence early in childhood, given the long gestation of nutritionally related cancers. Obesity avoidance is definitely a target for both pediatric and adult cancer prevention, commencing in childhood. There is now compelling evidence that the nutritional status of children with cancer, both overweight and underweight, does affect cancer outcomes. This is a potentially modifiable prognostic factor. Consistent longitudinal nutritional assessment of patients from diagnosis through treatment and long-term follow-up is required so that interventions can be implemented and evaluated. While improving, there remains a dearth of basic and clinical nutritional research in pediatric oncology. The perspective of evaluating nutrition as a cancer control factor is discussed in this article.


Assuntos
Neoplasias/dietoterapia , Apoio Nutricional/métodos , Criança , Transtornos da Nutrição Infantil/dietoterapia , Transtornos da Nutrição Infantil/metabolismo , Transtornos da Nutrição Infantil/patologia , Humanos , Neoplasias/metabolismo , Neoplasias/patologia , Estado Nutricional
7.
Nutr. hosp ; 37(1): 137-146, ene.-feb. 2020. tab
Artigo em Espanhol | IBECS | ID: ibc-187584

RESUMO

Introducción: los conflictos forman parte de las relaciones humanas. Pocos estudios han contemplado los conflictos que la alimentación puede producir en la fase final de la vida, los factores que inciden en su aparición y la forma de gestionarlos. Su conocimiento ayudaría al equipo asistencial a mejorar el cuidado de estos pacientes y sus familias. Objetivo: analizar la existencia del conflicto intrafamiliar vinculado con la alimentación en la enfermedad oncológica en cuidados paliativos, la gestión del mismo y la influencia en su aparición de los cambios en la alimentación, el control sobre la misma, la necesidad de comer, el acompañamiento, la adaptación a la enfermedad y la vinculación de la alimentación con la supervivencia, la calidad de vida y el cuidado. Métodos: el diseño del estudio fue transversal. Se recogieron datos de 57 parejas formadas por un paciente oncológico en cuidados paliativos y su cuidador principal por medio de una entrevista ad hoc validada y de la escala Perceived Adjustement to Chronic Illness Scale (PACIS). Los datos se analizaron mediante análisis de contenidos y análisis descriptivos e inferenciales. Resultados: pacientes y cuidadores reconocieron la existencia de un conflicto relacionado con la alimentación del paciente (49,1% y 54,4%), gestionándolo cerca del 30% de forma inadecuada. Ninguna de las variables analizadas resultó estadísticamente significativa en relación a la aparición del conflicto (considerando p < 0,05), excepto la necesidad de comer del paciente (?² = 9,163; p = 0,027). Conclusiones: el conflicto intrafamiliar debido a la alimentación se presenta como un problema que requiere reflexión, análisis e intervención por parte del equipo asistencial, dado que no se han podido establecer todos los factores que inciden en su aparición


Introduction: conflicts are part of human relationships. Few studies have looked at the conflicts that food can produce at the end of life, the factors that affect its appearance, and the way to manage them. This knowledge would help healthcare teams to improve the care of these patients and their families. Aim: to analyze the existence of a family conflict linked to food in palliative-care oncological patients, its management, and the influence on their appearance of changes in diet, diet control, need to eat, support, adaptation to disease, and the association of feeding with survival, quality of life, and care. Methods: the design of the study was cross-sectional. Data from 57 palliative-care oncological patient-family caregiver pairs were collected through a validated ad hoc interview and the PACIS scale. The data was analyzed through content analyses and descriptive and inferential analyses. Results: patients and caregivers recognized the existence of conflict related to the patient's diet (49.1 % and 54.4 %), with approximately 30 % managing it in an inappropriate way. None of the analyzed variables was statistically significant in relation to conflict appearance (considering p < 0.05), except patient need to eat (?² = 9.163, p = 0,027). Conclusions: family conflict due to patient feeding is reported as a problem that requires reflection, analysis, and intervention by the healthcare team, given that all factors involved in its appearance could not be established


Assuntos
Humanos , 24439 , Dissidências e Disputas , Cuidados Paliativos na Terminalidade da Vida , Neoplasias/dietoterapia , Serviço Hospitalar de Nutrição , Família , Pacientes , Cuidadores , Sobrevivência , Qualidade de Vida , Estudos Transversais
8.
Pediatr Blood Cancer ; 67 Suppl 3: e28193, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-31994836

RESUMO

Childhood cancer survivor (CCS) numbers are increasing as a result of advances in both treatment and supportive care. This positive outcome is tempered by the recognition of a high burden of chronic health conditions. Here, we review the nutritional concerns of CCS, including dietary habits after treatment and the factors during treatment that may contribute to chronic health conditions. Dietary interventions that have been conducted in CCS will be summarized along with focused goals of these interventions. We will also address the need to leverage these interventions to reduce the risk of chronic disease in CCS.


Assuntos
Neoplasias/dietoterapia , Neoplasias/metabolismo , Apoio Nutricional/métodos , Sobreviventes de Câncer , Criança , Países Desenvolvidos , Comportamentos Relacionados com a Saúde , Humanos , Neoplasias/mortalidade , Neoplasias/reabilitação , Apoio Nutricional/economia , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do Tratamento
9.
Med Oncol ; 37(2): 14, 2020 Jan 11.
Artigo em Inglês | MEDLINE | ID: mdl-31927631

RESUMO

Preclinical data provide evidence for synergism between ketogenic diets (KDs) and other oncological therapies. The aim of this systematic review was to summarize data from clinical studies that have tested KDs along with other treatments used within medical oncology. The PubMed database was searched using the key words "ketogenic" AND ("cancer" OR "glioblastoma"). A secondary search was conducted by screening the reference lists of relevant articles on this topic. Relevant studies for this review were defined as studies in which KDs were used complementary to surgery, radio-, chemo-, or targeted therapy and at least one of the following four outcomes were reported: (i) Overall survival (OS); (ii) progression-free survival (PFS); (iii) local control rate; (iv) body composition changes. Twelve papers reporting on 13 clinical studies were identified. Nine studies were prospective and six had a control group, but only two were randomized. KD prescription varied widely between studies and was described only rudimentarily in most papers. Adverse events attributed to the diet were rare and only minor (grade 1-2) except for one possibly diet-related grade 4 event. Studies reporting body composition changes found beneficial effects of KDs in both overweight and frail patient populations. Beneficial effects of KDs on OS and/or PFS were found in four studies including one randomized controlled trial. Studies in high-grade glioma patients were not sufficiently powered to prove efficacy. Evidence for beneficial effects of KDs during cancer therapy is accumulating, but more high-quality studies are needed to assess the overall strength of evidence.


Assuntos
Dieta Cetogênica , Neoplasias/terapia , Composição Corporal , Ensaios Clínicos como Assunto , Terapia Combinada , Feminino , Glioblastoma/mortalidade , Glioblastoma/terapia , Glioma/mortalidade , Glioma/terapia , Humanos , Masculino , Oncologia , Neoplasias/dietoterapia , Neoplasias/mortalidade , Intervalo Livre de Progressão , Taxa de Sobrevida
10.
Support Care Cancer ; 28(3): 979-1010, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31813021

RESUMO

INTRODUCTION: Weight loss in cancer patients is a worrisome constitutional change predicting disease progression and shortened survival time. A logical approach to counter some of the weight loss is to provide nutritional support, administered through enteral nutrition (EN) or parenteral nutrition (PN). The aim of this paper was to update the original systematic review and meta-analysis previously published by Chow et al., while also assessing publication quality and effect of randomized controlled trials (RCTs) on the meta-conclusion over time. METHODS: A literature search was carried out; screening was conducted for RCTs published in January 2015 up until December 2018. The primary endpoints were the percentage of patients achieving no infection and no nutrition support complications. Secondary endpoints included proportion of patients achieving no major complications and no mortality. Review Manager (RevMan 5.3) by Cochrane IMS and Comprehensive Meta-Analysis (version 3) by Biostat were used for meta-analyses of endpoints and assessment of publication quality. RESULTS: An additional seven studies were identified since our prior publication, leading to 43 papers included in our review. The results echo those previously published; EN and PN are equivalent in all endpoints except for infection. Subgroup analyses of studies only containing adults indicate identical risks across all endpoints. Cumulative meta-analysis suggests that meta-conclusions have remained the same since the beginning of publication time for all endpoints except for the endpoint of infection, which changed from not favoring to favoring EN after studies published in 1997. There was low risk of bias, as determined by assessment tool and visual inspection of funnel plots. CONCLUSIONS: The results support the current European Society of Clinical Nutrition and Metabolism guidelines recommending enteral over parenteral nutrition, when oral nutrition is inadequate, in adult patients. Further studies comparing EN and PN for these critical endpoints appear unnecessary, given the lack of change in meta-conclusion and low publication bias over the past decades.


Assuntos
Nutrição Enteral/métodos , Neoplasias/dietoterapia , Nutrição Parenteral/métodos , Nutrição Enteral/efeitos adversos , Nutrição Enteral/mortalidade , Humanos , Infecções/epidemiologia , Neoplasias/metabolismo , Neoplasias/microbiologia , Neoplasias/mortalidade , Estado Nutricional , Nutrição Parenteral/efeitos adversos , Nutrição Parenteral/mortalidade , Ensaios Clínicos Controlados Aleatórios como Assunto , Perda de Peso
11.
Crit Rev Food Sci Nutr ; 60(4): 684-694, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-30570346

RESUMO

Current evidence on selenium and its effects on cancer is conflicting. This study aimed at assessing the association between dietary intake of selenium and incidence of cancers by performing systematic review and meta-analysis of population-based prospective studies. We systematically searched for articles in Medline (Ovid), Embase, Web of Science (Thomson Reuters), China National Knowledge Infrastructure, Wanfang Database and VIP Chinese Scientific Journals. Analysis was performed in Stata version 14.2. Of the 2,564 articles obtained from the databases, 39 met our inclusion criteria, 37 were included in the final analysis. Selenium at recommended daily allowance levels of ≥55 µg/day decreased the risk of cancer [relative risk (RR) = 0.94, 95% confidence interval (CI): 0.90-0.98]. A protective effect was found in men at levels ≥55 µg/day (RR = 0.97, 95% CI: 0.94-0.99). Extra selenium intake from supplements was protective at levels ≥55 µg/day (RR = 0.89, 95% CI: 0.82-0.97). There was an inverse relationship (p value = 0.020) between selenium intake and overall cancer risk after adjusting for age, body mass index, and smoking but there was no evidence of nonlinear relationship (p value = 0.261). The findings in this study suggest that selenium is protective against cancer however the effects vary with different cancers.


Assuntos
Dieta , Suplementos Nutricionais , Neoplasias/epidemiologia , Neoplasias/prevenção & controle , Selênio/administração & dosagem , Selênio/farmacologia , Humanos , Neoplasias/classificação , Neoplasias/dietoterapia , Estudos Prospectivos
13.
Biomed Res Int ; 2019: 7010467, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31737673

RESUMO

Apigenin is a flavonoid of low toxicity and multiple beneficial bioactivities. Published reviews all focused on the findings using eukaryotic cells, animal models, or epidemiological studies covering the pharmacokinetics, cancer chemoprevention, and drug interactions of apigenin; however, no review is available on the antimicrobial effects of apigenin. Research proves that dietary apigenin passes through the upper gastrointestinal tract and reaches the colon after consumption. For that reason, it is worthwhile to study the potential interactions between apigenin and human gut microbiota. This review summarizes studies on antimicrobial effects of apigenin as well as what has been reported on apigenin and human gut microbiota. Various levels of effectiveness have been reported on apigenin's antibacterial, antifungal, and antiparasitic capability. It has been shown that apigenin or its glycosides are degraded into smaller metabolites by certain gut bacteria which can regulate the human body after absorption. How apigenin contributes to the structural and functional changes in human gut microbiota as well as the bioactivities of apigenin bacterial metabolites are worth further investigation.


Assuntos
Anti-Infecciosos/uso terapêutico , Apigenina/uso terapêutico , Flavonoides/uso terapêutico , Microbioma Gastrointestinal/efeitos dos fármacos , Animais , Anti-Infecciosos/farmacocinética , Apigenina/farmacocinética , Bactérias/efeitos dos fármacos , Suplementos Nutricionais , Flavonoides/farmacocinética , Humanos , Neoplasias/dietoterapia
15.
Recenti Prog Med ; 110(10): 503-504, 2019 Oct.
Artigo em Italiano | MEDLINE | ID: mdl-31657817
16.
Postepy Biochem ; 65(3): 163-172, 2019 09 30.
Artigo em Polonês | MEDLINE | ID: mdl-31643163

RESUMO

The intestinal microflora plays a key role in maintaining homeostasis in the human body. Microbes affect, among others, energy conversion and absorption of nutrients, regulate immune system and help to protect the host organism from pathogenic microorganisms. The balanced composition of the intestinal microflora can be easily disturbed and any changes caused by diet, stress, obesity, diseases of the digestive system or medication may lead to pro-inflammatory immune responses and initiation of disease processes, including cancer. Maintaining intestinal microflora homeostasis is therefore extremely important for human health. In order to restore it, it is most often used to take specimens with appropriate bacterial cultures, i. e. probiotics. Due to the fact that yoghurts are a source of probiotic bacteria, their regular consumption may be a strong point in the prevention of various types of diseases, including civilization diseases and cancer. This article reviews the literature in the area of using yogurt bacteria in the prevention of cancer. Issues addressed in the article relate to the characteristics of yogurt bacteria, beneficial effects of probiotics on human health, anti-cancer properties of yogurt bacteria and their metabolites, i. e. immunoregulation, prevention of bacterial infections, maintenance of cellular connections in the intestine and anti-cancer activity of bacterial metabolites.


Assuntos
Bactérias , Neoplasias/dietoterapia , Neoplasias/prevenção & controle , Probióticos , Iogurte/microbiologia , Bactérias/metabolismo , Homeostase , Humanos , Neoplasias/microbiologia , Probióticos/metabolismo
17.
Endocrinol. diabetes nutr. (Ed. impr.) ; 66(8): 472-479, oct. 2019.
Artigo em Espanhol | IBECS | ID: ibc-184140

RESUMO

Antecedentes y objetivo: El tratamiento con antineoplásicos orales tipo inhibidores de tirosina quinasa (ITK) es novedoso, y por ello se conoce poco sobre cómo afectan al estado nutricional (EN), la ingesta dietética, la calidad de vida, y su influencia sobre la supervivencia. Este estudio pretende aportar información sobre estos componentes, para dirigir las recomendaciones nutricionales futuras. Pacientes y método: Estudio prospectivo y observacional en adultos que inician ITK, donde se valoró el EN mediante el cuestionario de valoración subjetiva global generada por el paciente (VSG-GP), medidas antropométricas, parámetros bioquímicos e ingesta dietética (Recuerdo de 24 h). La calidad de vida se estudió con EORTC QLQ-C30. El análisis estadístico empleó pruebas no paramétricas y la supervivencia se analizó mediante curvas de Kaplan-Meier y log-rank. Resultados: El 21,7% de la muestra presentó desnutrición moderada según VSG-GP; el 74,2% mostró pérdida de peso moderada a los 6 meses, aunque ningún paciente tuvo un IMC < 18,5 kg/m2. Los pacientes moderadamente desnutridos presentaron menor supervivencia a los 4 años del diagnóstico (log-rank = 0,015). El 44,4% realizó una ingesta energética inferior a las recomendaciones ESPEN 2017 y ningún paciente cubrió requerimientos proteicos (1,5 g proteína/kg peso) durante el seguimiento. Una peor puntuación en la escala global de salud del EORTC QLQ-C30 se relacionó con peor EN. Conclusiones: El tratamiento con ITK no parece afectar de manera importante el EN y la calidad de vida a los 6 meses de seguimiento. Se debe prevenir la desnutrición, mediante un consejo nutricional individualizado, pues se relaciona con menor supervivencia


Background and objective: Treatment with oral antineoplastic agents known as tyrosine kinase inhibitors (TKIs) is new and, thus, little is known about their impact on nutritional status (NS), dietary intake, quality of life, and survival. The aim of this study was to provide information on these components in order to guide future nutritional recommendations. Patients and method: A prospective, observational study in adults who start treatment with TKIs, in whom NS was assessed using the Patient-Generated Subjective Global Assessment (PG-SGA), anthropometric measures, biochemical parameters, and dietary intake (24-hour dietary recall). The EORTC QLQ-C30 was used to assess quality of life. Nonparametric tests were used in statistical analysis, and survival was analyzed using Kaplan-Meier and log-rank curves. Results: Of the overall sample, 21.7% had moderate malnutrition according to PG-SGA, and 74.2% moderate weight loss at 6 months, but no patient had BMI < 18.5 kg/m2. Patients with moderate malnutrition had lower survival at four years of diagnosis (log-rank = 0.015). Energy intake was lower than recommended by the ESPEN 2017 congress, and no patient covered the protein requirements (1.5 g protein/kg weight) during follow-up. A worse score on the global health scale of the EORTC QLQ-C30 was related to worse NS. Conclusions: Treatment with TKIs does not appear to have a significant impact on NS and quality of life after 6 months of follow-up. Malnutrition should be prevented through individualized nutritional advice because it is related to shorter survival


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Sobrevivência , Neoplasias/epidemiologia , Estado Nutricional , Proteínas Tirosina Quinases/antagonistas & inibidores , Qualidade de Vida , Neoplasias/dietoterapia , Estudos Prospectivos , Inquéritos e Questionários , Antropometria , Dietoterapia , Dietética
18.
Nutrients ; 11(9)2019 Sep 02.
Artigo em Inglês | MEDLINE | ID: mdl-31480794

RESUMO

The Mediterranean diet is considered one of the most worldwide healthy dietary patterns thanks to a combination of foods rich mainly in antioxidants and anti-inflammatory nutrients. Many studies have demonstrated a strong and inverse relationship between a high level of Mediterranean diet adherence and some chronic diseases (such as cardiovascular diseases, diabetes, etc.) and cancer. Given its protective effects in reducing oxidative and inflammatory processes of cells and avoiding DNA damages, cell proliferation, and their survival, angiogenesis, inflammations and metastasis, the Mediterranean diet is considered a powerful and manageable method to fight cancer incidence. The aim of this narrative review was to determine the magnitude of interaction between the Mediterranean diet and more widespread types of cancer so as to give a first and useful overview on this relationship identifying, with a nutritional approach, those nutrients of Mediterranean diet able to reduce cancer incidence.


Assuntos
Dieta Mediterrânea , Neoplasias/dietoterapia , Neoplasias/prevenção & controle , Humanos
19.
BMC Cancer ; 19(1): 811, 2019 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-31416430

RESUMO

BACKGROUND: Diets that restrict energy or macronutrient intake (e.g. fasting/ketogenic diets (KDs)) may selectively protect non-tumour cells during cancer treatment. Previous reviews have focused on a subset of dietary restrictions (DR) or have not performed systematic searches. We conducted a systematic scoping review of DR at the time of cancer treatment. METHODS: MEDLINE, Embase, CINAHL, AMED and Web of Science databases were searched for studies of adults undergoing DR alongside treatment for cancer. Search results were screened against inclusion/exclusion criteria. Data from included studies were extracted by two independent reviewers. Results were summarised narratively. RESULTS: Twenty-three independent studies (34 articles), with small sample sizes, met the inclusion criteria. Four categories were identified: KDs (10 studies), fasting (4 studies), protein restriction (5 studies) and combined interventions (4 studies). Diets were tolerated well, however adherence was variable, particularly for KDs. Biomarker analysis in KDs and fasting resulted in the expected increase in ketones or reduction in insulin-like growth factors, respectively, however they did not reduce glucose. CONCLUSIONS: Future research with adequately powered studies is required to test the effects of each DR intervention on treatment toxicities and outcomes. Further research into improving adherence to DR may improve the feasibility of larger trials.


Assuntos
Dieta Cetogênica , Dieta com Restrição de Proteínas , Jejum , Neoplasias/dietoterapia , Neoplasias/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Humanos , Pessoa de Meia-Idade , Neoplasias/metabolismo , Adulto Jovem
20.
Eur J Med Chem ; 181: 111579, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31398616

RESUMO

Many bioactive agents have been extracted from plants or belong to functional foods and have been considered in the treatment of serious and multifactorial diseases, such as cancer. In particular, this review is focused on the anti-cancer properties owned by several natural products typically from the Mediterranean area. In some regions of the South of Italy, a lower cancer incidence has been observed. There is increasing evidence that adherence to a Mediterranean dietary pattern correlates with reduced risk of several cancer types. This could be mainly attributed to the typical lifestyle aspects of the Mediterranean diet, such as high consumption of fruit and vegetables. In this review, the main natural products of the Mediterranean area are discussed, with particular attention on their anti-cancer properties endowed with multi-target profiles.


Assuntos
Dieta Mediterrânea , Neoplasias/prevenção & controle , Anticarcinógenos/análise , Anticarcinógenos/uso terapêutico , Antioxidantes/análise , Antioxidantes/uso terapêutico , Frutas/química , Humanos , Neoplasias/dietoterapia , Azeite de Oliva/análise , Azeite de Oliva/uso terapêutico , Verduras/química , Vinho/análise
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA