Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 21.076
Filtrar
1.
Sci Data ; 9(1): 638, 2022 10 21.
Artigo em Inglês | MEDLINE | ID: mdl-36270998

RESUMO

In Italy, approximately 400.000 new cases of malignant tumors are recorded every year. The average of annual deaths caused by tumors, according to the Italian Cancer Registers, is about 3.5 deaths and about 2.5 per 1,000 men and women respectively, for a total of about 3 deaths every 1,000 people. Long-term (at least a decade) and spatially detailed data (up to the municipality scale) are neither easily accessible nor fully available for public consultation by the citizens, scientists, research groups, and associations. Therefore, here we present a ten-year (2009-2018) database on cancer mortality rates (in the form of Standardized Mortality Ratios, SMR) for 23 cancer macro-types in Italy on municipal, provincial, and regional scales. We aim to make easily accessible a comprehensive, ready-to-use, and openly accessible source of data on the most updated status of cancer mortality in Italy for local and national stakeholders, researchers, and policymakers and to provide researchers with ready-to-use data to perform specific studies.


Assuntos
Neoplasias , Feminino , Humanos , Masculino , Bases de Dados Factuais , Itália/epidemiologia , Neoplasias/mortalidade
5.
Rev. Rol enferm ; 45(9): 9-19, Sept. 2022. tab, ilus
Artigo em Espanhol | IBECS | ID: ibc-211099

RESUMO

Introducción: La recuperación del dolor de una familia por la muerte de un niño obedece a la forma en la que se cuida la etapa final de su vida, y es especialmente en esta etapa, donde Enfermería juega un papel fundamental en el apoyo a la familia que enfrenta la enfermedad crítica y la muerte de un hijo.Objetivos: Revisar la literatura científica existente sobre el manejo del duelo en familiares de pacientes oncopediátricos.Metodología: Revisión integradora exhaustiva en las bases de datos Pudmed, Scopus, Scielo y Cochrane. Fueron empleados los términos “oncology pediatric”, “family”, “grief” y “nursing”, unidos por el operador boleano “AND”.Resultados: Se han identificado las experiencias emocionales que siente la familia del paciente oncohematológico pediátrico y las habilidades en la práctica enfermera que protegen el cuidado emocional de la misma. Por su relevancia en este ámbito, cabe destacar la relación terapéutica entre la familia, el niño, y el equipo sanitario, y el poder de la habilidad comunicativa en la etapa final de la vida y la muerte.Conclusiones: El cuidado de la integridad emocional y del curso natural del duelo es vital dentro del plan de cuidados del niño y su familia. Subrayar la magnitud que tendría el entrenamiento de Enfermería en habilidades emocionales, comunicativas y psico-conductuales dentro de la atención integral del niño y su familia. (AU)


Introduction: Recovery from the pain of a family due to the death of a child is due to the way in which the final stage of life is cared for, and it is especially at this stage where Nursing plays a fundamental role in supporting the family facing critical illness and the death of a child.Objectives: To review the existing scientific literature on the management of grief in relatives of oncopediatric patients.Methodology: Comprehensive integrative review in the Pudmed, Scopus, Scielo and Cochrane databases. The terms «pediatric oncology», «family», «mourning» and «nursing» were used, joined by the Boolean operator «Y».Results: The emotional experiences felt by the family of the pediatric oncohematological patient and the skills in nursing practice that protect the emotional care of the same have been identified. Due to its relevance in this area, it is worth highlighting the therapeutic relationship between the family, the child, and the healthcare team, and the power of communication skills in the final stage of life and death.Conclusions: Caring for the emotional integrity and the natural course of grief is vital in the care plan for the child and his family. Emphasize the magnitude that should be the nursing training in emotional, communication and psycho-behavioral skills for the comprehensive care of the child and his family. (AU)


Assuntos
Humanos , Pesar , Oncologia , Pediatria , Família , Neoplasias/mortalidade , Enfermagem
7.
Goiânia; SES-GO; 18 ago. 2022. 1-10 p. ilus, graf, mapas, tab.
Não convencional em Português | LILACS, Coleciona SUS, CONASS, SES-GO | ID: biblio-1398826

RESUMO

O crescimento desordenado de células no organismo, que pode invadir tecidos adjacentes ou órgãos em outras regiões do corpo, é denominado câncer (WHO, 2022a). A nomenclatura da doença corresponde ao local de foco inicial, e assim, os cânceres de mama, próstata, pulmão, colorretal, colo uterino e estômago são os mais frequentes. Globalmente, uma em cada seis mortes são relacionadas à doença, que configura a segunda principal causa de morte. E os tipos de câncer que mais evoluem para óbito são pulmão, mama, colorretal, fígado, próstata e estômago (WHO, 2022b)


The disordered growth of cells in the body, which can invade adjacent tissues or organs in other regions of the body, is called cancer (WHO, 2022a). The disease nomenclature corresponds to the initial focus site, and thus, breast, prostate, lung, colorectal, uterine cervix and stomach cancers are the most frequent. Globally, one in every six deaths are related to the disease, which is the second leading cause of death. And the types of cancer that most evolve to death are lung, breast, colorectal, liver, prostate and stomach (WHO, 2022b)


Assuntos
Humanos , Masculino , Feminino , Criança , Idoso , Neoplasias/epidemiologia , Neoplasias/classificação , Neoplasias/mortalidade
8.
Int. j. cardiovasc. sci. (Impr.) ; 35(4): 514-520, July-Aug. 2022. tab
Artigo em Inglês | LILACS | ID: biblio-1385273

RESUMO

Abstract Background: Due to its poor prognosis and mortality rates, heart failure (HF) has been recognized as a malignant condition, comparable to some cancers in developed countries. Objectives: To compare mortality from HF and prevalent cancers using data from a nationwide database in Brazil. Methods: This was a descriptive, cross-sectional study using secondary data obtained from Brazilian administrative databases of death records and hospitalization claims maintained by the Ministry of Health. Data were analyzed according to main diagnosis, year of occurrence (2005-2015), sex and age group. Descriptive analyses of absolute number of events, hospitalization rate, mortality rate, and in-hospital mortality rate were performed. Results: The selected cancers accounted for higher mortality, lower hospitalization and higher in-hospital mortality rates than HF. In a group analysis, HF showed mortality rates of 100-150 per 100,000 inhabitants over the period, lower than the selected cancers. However, HF had a higher mortality rate than each type of cancer, even when compared to the most prevalent and deadly ones. Regarding hospitalization rates, HF was associated with a higher risk of hospitalization when compared to cancer-related conditions as a group. Conclusions: Our findings indicate that HF has an important impact on mortality, hospitalization and in-hospital mortality, comparable to or even worse than some types of cancer, representing a potential burden to the healthcare system.


Assuntos
Humanos , Masculino , Feminino , Insuficiência Cardíaca/mortalidade , Neoplasias/mortalidade , Prognóstico , Brasil , Epidemiologia Descritiva , Estudos Transversais , Mortalidade Hospitalar , Insuficiência Cardíaca/diagnóstico , Hospitalização , Neoplasias/diagnóstico
10.
Khirurgiia (Mosk) ; (7): 12-18, 2022.
Artigo em Russo | MEDLINE | ID: mdl-35775840

RESUMO

OBJECTIVE: To analyze treatment outcomes and approaches to predicting the postoperative morbidity and mortality in patients with perforated ulcers and cancer. MATERIAL AND METHODS: A non-randomized trial included 194 patients. The first group enrolled 45 (23%) patients with perforated ulcers and concomitant cancer who underwent at the oncology center; the second group included 149 (77%) patients with perforated ulcers and no cancer who underwent surgery in general surgical hospitals. Organ-sparing procedures prevailed (40 (88.9%) and 138 (92.6%) cases, respectively). Resections were performed in 5 (11.1%) and 11 (7.4%) patients respectively. Analyzing the factors affecting treatment outcomes, we studied crude (COR) and adjusted (AOR) odds ratios. ROC-analysis was used to assess diagnostic significance of the models for prognosis of morbidity and mortality. RESULTS: Length of hospital-stay was 10 (range 9-14) and 8 (range 7-9) days respectively. Postoperative complications (Clavien-Dindo grading system) occurred in 18 (40%) in 37 (24.8%) patients, respectively. According to multivariate analysis, predictors of complications in patients of the first group were treatment with NSAIDs/glucocorticoids and Charlson-Deyo index >3. Sensitivity of this model was 82.4%, specificity - 75.0%. Postoperative mortality was 15.6% (n=7) and 7.4% (n=11) respectively. According to multivariate analysis, predictors of mortality were age over 65 years and more than 5 chemotherapeutic courses. Sensitivity of the model was 85.7%, specificity - 97.4%. CONCLUSION: The stratified approach makes it possible to improve prediction of postoperative morbidity and mortality in patients with perforated ulcers.


Assuntos
Neoplasias , Úlcera Péptica Perfurada , Idoso , Humanos , Morbidade , Neoplasias/complicações , Neoplasias/tratamento farmacológico , Neoplasias/mortalidade , Úlcera Péptica Perfurada/complicações , Úlcera Péptica Perfurada/mortalidade , Úlcera Péptica Perfurada/cirurgia , Período Pós-Operatório , Prognóstico
11.
Sci Rep ; 12(1): 10875, 2022 06 27.
Artigo em Inglês | MEDLINE | ID: mdl-35760845

RESUMO

The purpose of this paper is to offer the most important epidemiological indicators of malignant neoplasms in Poland for the year 2019. In 2019, the Polish National Cancer Registry received information on almost 171.2 thousand new cancer cases and 100.3 thousand cancer deaths. The most common male cancers were prostate (20.6%), lung (16.1%), colon (6.8%), bladder (6.4%), and rectal (4.2%) cancers. Age-standardized incidence rates were at 118 per 100,000 for prostate, 89 for lung, 40 for colon, 38 for bladder, and 23 for the rectum. The most prevalent female cancers encompassed breast (22.9%), lung (9.9%), corpus uteri (7.0%), colon (5.9%), and ovary (4.3%). Age-standardized incidence rate was at 95 per 100,000 for breast cancer, 40 for lung 40, 29 for corpus uteri, 24 for colon, and 18 for ovarian cancer. The five leading causes of male cancer deaths were cancer of the lung (27.4%), prostate (10.3%), colon (8.0%), bladder (5.8%), and stomach (5.7%). Age-standardized mortality rates were 100 per 100,000 for lung, 46 for prostate, 32 for colon, 24 for urinary bladder, and 22 for stomach cancer. Most female deaths due to cancer were caused by lung (17.9%), breast (15.1%), colon (7.7%), ovary (6.0%), pancreas (5.7%), and corpus uteri (4.0%) cancers. Age-standardized mortality rates were 39 per 100,000 for lung, 33 for breast, 17 for colon, 13 for ovarian, 13 for pancreatic, and 9 for corpus uteri cancer.


Assuntos
Neoplasias , Feminino , Humanos , Incidência , Masculino , Neoplasias/mortalidade , Polônia/epidemiologia , Sistema de Registros
12.
JAMA ; 327(24): 2423-2433, 2022 06 28.
Artigo em Inglês | MEDLINE | ID: mdl-35657620

RESUMO

Importance: Obesity increases the incidence and mortality from some types of cancer, but it remains uncertain whether intentional weight loss can decrease this risk. Objective: To investigate whether bariatric surgery is associated with lower cancer risk and mortality in patients with obesity. Design, Setting, and Participants: In the SPLENDID (Surgical Procedures and Long-term Effectiveness in Neoplastic Disease Incidence and Death) matched cohort study, adult patients with a body mass index of 35 or greater who underwent bariatric surgery at a US health system between 2004 and 2017 were included. Patients who underwent bariatric surgery were matched 1:5 to patients who did not undergo surgery for their obesity, resulting in a total of 30 318 patients. Follow-up ended in February 2021. Exposures: Bariatric surgery (n = 5053), including Roux-en-Y gastric bypass and sleeve gastrectomy, vs nonsurgical care (n = 25 265). Main Outcomes and Measures: Multivariable Cox regression analysis estimated time to incident obesity-associated cancer (a composite of 13 cancer types as the primary end point) and cancer-related mortality. Results: The study included 30 318 patients (median age, 46 years; median body mass index, 45; 77% female; and 73% White) with a median follow-up of 6.1 years (IQR, 3.8-8.9 years). The mean between-group difference in body weight at 10 years was 24.8 kg (95% CI, 24.6-25.1 kg) or a 19.2% (95% CI, 19.1%-19.4%) greater weight loss in the bariatric surgery group. During follow-up, 96 patients in the bariatric surgery group and 780 patients in the nonsurgical control group had an incident obesity-associated cancer (incidence rate of 3.0 events vs 4.6 events, respectively, per 1000 person-years). The cumulative incidence of the primary end point at 10 years was 2.9% (95% CI, 2.2%-3.6%) in the bariatric surgery group and 4.9% (95% CI, 4.5%-5.3%) in the nonsurgical control group (absolute risk difference, 2.0% [95% CI, 1.2%-2.7%]; adjusted hazard ratio, 0.68 [95% CI, 0.53-0.87], P = .002). Cancer-related mortality occurred in 21 patients in the bariatric surgery group and 205 patients in the nonsurgical control group (incidence rate of 0.6 events vs 1.2 events, respectively, per 1000 person-years). The cumulative incidence of cancer-related mortality at 10 years was 0.8% (95% CI, 0.4%-1.2%) in the bariatric surgery group and 1.4% (95% CI, 1.1%-1.6%) in the nonsurgical control group (absolute risk difference, 0.6% [95% CI, 0.1%-1.0%]; adjusted hazard ratio, 0.52 [95% CI, 0.31-0.88], P = .01). Conclusions and Relevance: Among adults with obesity, bariatric surgery compared with no surgery was associated with a significantly lower incidence of obesity-associated cancer and cancer-related mortality.


Assuntos
Cirurgia Bariátrica , Neoplasias , Obesidade , Adulto , Cirurgia Bariátrica/métodos , Cirurgia Bariátrica/estatística & dados numéricos , Estudos de Coortes , Feminino , Gastrectomia/métodos , Gastrectomia/estatística & dados numéricos , Derivação Gástrica/métodos , Derivação Gástrica/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias/epidemiologia , Neoplasias/etiologia , Neoplasias/mortalidade , Obesidade/complicações , Obesidade/epidemiologia , Obesidade/mortalidade , Obesidade/cirurgia , Obesidade Mórbida/complicações , Obesidade Mórbida/epidemiologia , Obesidade Mórbida/mortalidade , Obesidade Mórbida/cirurgia , Estudos Retrospectivos , Risco , Estados Unidos/epidemiologia , Redução de Peso
14.
JAMA Oncol ; 8(8): 1184-1189, 2022 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-35587341

RESUMO

Importance: Cancer is the second leading cause of mortality in the US. Despite national decreases in cancer mortality, Black individuals continue to have the highest cancer death rates. Objective: To examine national trends in cancer mortality from 1999 to 2019 among Black individuals by demographic characteristics and to compare cancer death rates in 2019 among Black individuals with rates in other racial and ethnic groups. Design, Setting, and Participants: This serial cross-sectional study used US national death certificate data obtained from the National Center for Health Statistics and included all cancer deaths among individuals aged 20 years or older from January 1999 to December 2019. Data were analyzed from June 2021 to January 2022. Exposures: Age, sex, and race and ethnicity. Main Outcomes and Measures: Trends in age-standardized mortality rates and average annual percent change (AAPC) in rates were estimated by cancer type, age, sex, and race and ethnicity. Results: From 1999 to 2019, 1 361 663 million deaths from cancer occurred among Black individuals. The overall cancer death rate significantly decreased among Black men (AAPC, -2.6%; 95% CI, -2.6% to -2.6%) and women (AAPC, -1.5%; 95% CI, -1.7% to -1.3%). Death rates decreased for most cancer types, with the greatest decreases observed for lung cancer among men (AAPC, -3.8%; 95% CI, -4.0% to -3.6%) and stomach cancer among women (AAPC, -3.4%; 95% CI, -3.6% to -3.2%). Lung cancer mortality also had the largest absolute decreases among men (-78.5 per 100 000 population) and women (-19.5 per 100 000 population). We observed a significant increase in deaths from liver cancer among men (AAPC, 3.8%; 95% CI, 3.0%-4.6%) and women (AAPC, 1.8%; 95% CI, 1.2%-2.3%) aged 65 to 79 years. There was also an increasing trend in uterus cancer mortality among women aged 35 to 49 years (2.9%; 95% CI, 2.3% to 2.6%), 50 to 64 years (2.3%; 95% CI, 2.0% to 2.6%), and 65 to 79 years (1.6%; 95% CI, 1.2% to 2.0%). In 2019, Black men and women had the highest cancer mortality rates compared with non-Hispanic American Indian/Alaska Native, Asian or Pacific Islander, and White individuals and Hispanic/Latino individuals. Conclusions and Relevance: In this cross-sectional study, there were substantial decreases in cancer death rates among Black individuals from 1999 to 2019, but higher cancer death rates among Black men and women compared with other racial and ethnic groups persisted in 2019. Targeted interventions appear to be needed to eliminate social inequalities that contribute to Black individuals having higher cancer mortality.


Assuntos
Afro-Americanos , Disparidades nos Níveis de Saúde , Neoplasias , Adulto , Afro-Americanos/estatística & dados numéricos , Idoso , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Mortalidade/etnologia , Mortalidade/tendências , Neoplasias/etnologia , Neoplasias/mortalidade , Estados Unidos/epidemiologia
16.
Int J Paleopathol ; 37: 77-86, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35576812

RESUMO

OBJECTIVE: To investigate if there were changes in mortality knowing that industrialization was a slow and late process in Portugal. MATERIALS: The biographic information (1) of the individuals buried at the Coimbra Municipal Cemetery, considering three quinquennia: 1861-1865 (n = 1111, 18.3%), 1870-1974 (n = 2602, 42.7%), 1910-1914 (n = 2374, 39.0%), related to the periods before, during and at the end of the second industrialization and (2) of the Coimbra identified osteological collections (CIOC, N = 1796) composed of individuals who were born and died in the city. METHODS: Excel databases with the biographic information were analyzed with SPSS. RESULTS: Data from the cemetery show statistically significant differences between sexes and age-at-death mortalities. Non-adult mortality (higher in the age range from 1 to 7 years) has decreased over time which has increased mean age-at-death. The main adult occupations are domestic work (females) and craft activities (males). Child labor is common after the age of 14. The main causes of death (in both cemetery and CIOC records) were infections, respiratory diseases, heart disease, and malignant neoplasm. Among the communicable diseases, tuberculosis accounted for the highest number of deaths. The identified individuals have lesions compatible with tuberculosis and sinusitis while malignant neoplasms are more difficult to identify. The high prevalence of heart disease can overshadow other causes of death. CONCLUSIONS: In the absence of industrialization, tuberculosis, heart disease, and malignant neoplasms increased over time, while respiratory diseases decreased. SIGNIFICANCE: Mortality profile changed between 1861-1864 and 1910-1914 in Coimbra. LIMITATIONS: The causes of death were studied, but not all diseases. SUGGESTIONS FOR FURTHER RESEARCH: Study of other cemetery records for further comparison.


Assuntos
Cemitérios , Doenças Transmissíveis/mortalidade , Cardiopatias/mortalidade , Neoplasias/mortalidade , Doenças Respiratórias/mortalidade , Adulto , Fatores Etários , Causas de Morte , Cemitérios/estatística & dados numéricos , Criança , Pré-Escolar , Bases de Dados Factuais , Feminino , Humanos , Lactente , Masculino , Ocupações/classificação , Portugal/epidemiologia , Fatores Sexuais , Tuberculose/mortalidade
17.
Cancer Epidemiol Biomarkers Prev ; 31(7): 1298-1304, 2022 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-35477176

RESUMO

BACKGROUND: Disease-specific mortality is a consensus endpoint in cancer screening trials. New liquid biopsy-based screening tests, including multi-cancer early detection (MCED) tests, are creating a need to reduce the typically lengthy screening trial process. Endpoints based on the reduction in late-stage disease (stage shift) have been proposed but it is unclear how well they predict the impact of screening on disease-specific mortality across a variety of cancers potentially detectable by MCED tests. METHODS: We develop a mathematical formulation relating the reduction in late-stage cancer to the expected reduction in disease-specific mortality if cases diagnosed early via screening receive a corresponding shift in mortality. We investigate the similarity between the expected mortality reduction and the observed mortality reduction in published trials of screening for breast, lung, ovarian, and prostate cancer. RESULTS: The expected mortality reduction for a given stage shift varies significantly depending on cancer- and stage-specific survival distributions, with some cancer types showing little possibility for mortality improvement even under substantial stage shift. The expected mortality reduction fails to consistently match the mortality outcomes of published trials. CONCLUSIONS: In MCED, any mortality benefit is likely to vary substantially across target cancers. Stage shift does not appear to be a reliable basis for inference about mortality reduction across cancers potentially detectable by MCED tests. IMPACT: Stage shift may be an appealing endpoint for evaluation of cancer screening tests but it appears to be an unreliable predictor of mortality benefit; furthermore, the same stage shift can mean different things for different cancers.


Assuntos
Detecção Precoce de Câncer , Neoplasias , Humanos , Programas de Rastreamento , Modelos Teóricos , Neoplasias/diagnóstico , Neoplasias/mortalidade
19.
J Cachexia Sarcopenia Muscle ; 13(4): 2064-2072, 2022 08.
Artigo em Inglês | MEDLINE | ID: mdl-35478277

RESUMO

BACKGROUND: Muscle wasting is prevalent in cancer patients, and early recognition of this phenomenon is important for risk stratification. Recent studies have suggested that the creatinine-cystatin C ratio may correlate with muscle mass in several patient populations. The association between creatinine-cystatin C ratio and survival was assessed in cancer patients. METHODS: A total of 3060 patients who were evaluated for serum creatinine and cystatin C levels at the time of cancer diagnosis were included. The primary outcome was 6-month mortality. The 1-year mortality, and length of intensive care unit (ICU) and hospital stay were also evaluated. RESULTS: The mean age was 61.6 ± 13.5 years, and 1409 patients (46.0%) were female. The median creatinine and cystatin C levels were 0.9 (interquartile range [IQR], 0.6-1.3) mg/dL and 1.0 (IQR, 0.8-1.5) mg/L, respectively, with a creatinine-cystatin C ratio range of 0.12-12.54. In the Cox proportional hazards analysis, an increase in the creatinine-cystatin C ratio was associated with a significant decrease in the 6-month mortality (per 1 creatinine-cystatin C ratio, hazard ratio [HR] 0.35; 95% confidence interval [CI], 0.28-0.44). When stratified into quartiles, the risk of 6-month mortality was significantly lower in the highest quartile (HR 0.30; 95% CI, 0.24-0.37) than in the lowest quartile. Analysis of 1-year mortality outcomes revealed similar findings. These associations were independent of confounding factors. The highest quartile was also associated with shorter lengths of ICU and hospital stay (both P < 0.001). CONCLUSIONS: The creatinine-cystatin C ratio at the time of cancer diagnosis significantly associates with survival and hospitalization in cancer patients.


Assuntos
Creatinina , Cistatina C , Neoplasias , Idoso , Creatinina/sangue , Cistatina C/sangue , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias/complicações , Neoplasias/mortalidade , Modelos de Riscos Proporcionais , Estudos Retrospectivos
20.
Bone Joint J ; 104-B(3): 359-367, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35227088

RESUMO

AIMS: A recent report from France suggested an association between the use of cobalt-chrome (CoCr) femoral heads in total hip arthroplasties (THAs) and an increased risk of dilated cardiomyopathy and heart failure. CoCr is a commonly used material in orthopaedic implants. If the reported association is causal, the consequences would be significant given the millions of joint arthroplasties and other orthopaedic procedures in which CoCr is used annually. We examined whether CoCr-containing THAs were associated with an increased risk of all-cause mortality, heart outcomes, cancer, and neurodegenerative disorders in a large national database. METHODS: Data from the National Joint Registry was linked to NHS English hospital inpatient episodes for 374,359 primary THAs with up to 14.5 years' follow-up. We excluded any patients with bilateral THAs, knee arthroplasties, indications other than osteoarthritis, aged under 55 years, and diagnosis of one or more outcome of interest before THA. Implants were grouped as either containing CoCr or not containing CoCr. The association between implant construct and the risk of all-cause mortality and incident heart failure, cancer, and neurodegenerative disorders was examined. RESULTS: There were 158,677 individuals (42.4%) with an implant containing CoCr. There were 47,963 deaths, 27,332 heart outcomes, 35,720 cancers, and 22,025 neurodegenerative disorders. There was no evidence of an association between patients with CoCr implants and higher rates of any of the outcomes. CONCLUSION: CoCr-containing THAs did not have an increased risk of all-cause mortality, or clinically meaningful heart outcomes, cancer, or neurodegenerative disorders into the second decade post-implantation. Our findings will help reassure clinicians and the increasing number of patients receiving primary THA worldwide that the use of CoCr-containing implants is not associated with significant adverse systemic effects. Cite this article: Bone Joint J 2022;104-B(3):359-367.


Assuntos
Ligas de Cromo/efeitos adversos , Cardiopatias/etiologia , Cardiopatias/mortalidade , Prótese de Quadril/efeitos adversos , Neoplasias/etiologia , Neoplasias/mortalidade , Doenças Neurodegenerativas/etiologia , Doenças Neurodegenerativas/mortalidade , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/mortalidade , Idoso , Idoso de 80 Anos ou mais , Causas de Morte , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Desenho de Prótese , Sistema de Registros , Estudos Retrospectivos , Medição de Risco , Reino Unido
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...