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1.
Top Curr Chem (Cham) ; 378(1): 13, 2020 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-31925680

RESUMO

The use of magnetic nanoparticles (MNPs), such as iron oxide nanoparticles (IONPs), in biomedicine is considered to be a valuable alternative to the more traditional materials due to their chemical stability, cost-effectiveness, surface functionalization, and the possibility to selectively attach and transport targeted species to the desired location under a magnetic field. One of the many main applications of MNPs is DNA separation, which enables genetic material manipulation; consequently, MNPs are used in numerous biotechnological methods, such as gene transfection and molecular recognition systems. In addition, the interaction between the surfaces of MNPs and DNA molecules and the magnetic nature of the resulting composite have facilitated the development of safe and effective gene delivery vectors to treat significant diseases, such as cancer and neurological disorders. Furthermore, the special recognition properties of nucleic acids based on the binding capacity of DNA and the magnetic behavior of the nanoparticles allowing magnetic separation and concentration of analytes have led to the development of biosensors and diagnostic assays; however, both of these applications face important challenges in terms of the improvement of selective nanocarriers and biosensing capacity. In this review, we discuss some aspects of the properties and surface functionalization of MNPs, the interactions between DNA and IONPs, the preparation of DNA nanoplatforms and their biotechnological applications, such as the magnetic separation of DNA, magnetofection, preparation of DNA vaccines, and molecular recognition tools.


Assuntos
DNA/química , Compostos Férricos/química , Nanopartículas de Magnetita/química , Nanomedicina , DNA/isolamento & purificação , Portadores de Fármacos/química , Humanos , Neoplasias/diagnóstico , Neoplasias/tratamento farmacológico , Neoplasias/imunologia , Vacinas de DNA/química , Vacinas de DNA/imunologia
2.
Anticancer Res ; 40(1): 109-119, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31892559

RESUMO

BACKGROUND/AIM: Although molecular targeting therapy is an attractive treatment for cancer, resistance eventually develops in most cases. Here, we evaluated chemotherapeutic efficacy on non-small cell lung cancer (NSCLC) with acquired resistance to epidermal growth factor receptor inhibitors mechanistically. MATERIALS AND METHODS: Antitumor effects of taxotere were evaluated using multiple models, including xenograft, and patient-derived models developed from adenocarcinoma cancer patients. Protein expressions were analyzed after drug treatment. RESULTS: Taxotere inhibited tumor growth of NSCLC cells harboring drug resistance, and reduced the expression of phosphorylated MET proto-oncogene, receptor tyrosine kinase (MET). A tumor-inhibitory effect of taxotere was also demonstrated in vivo in xenografts in mice, patient-derived primary lung tumor cells and patient-derived xenograft with concomitant repression of phosphorylated MET expression. Chemotherapeutic and MET-targeting drug exhibited a synergistic cell growth-inhibitory effect. CONCLUSION: These results suggest that the anticancer drug taxane may be an adjuvant for lung tumors exhibiting enhanced signaling of MET networks.


Assuntos
Antineoplásicos/farmacologia , Docetaxel/farmacologia , Neoplasias/metabolismo , Proteínas Proto-Oncogênicas c-met/metabolismo , Animais , Biomarcadores , Linhagem Celular Tumoral , Proliferação de Células/efeitos dos fármacos , Modelos Animais de Doenças , Humanos , Camundongos , Neoplasias/tratamento farmacológico , Neoplasias/patologia , Fosforilação , Inibidores de Proteínas Quinases/farmacologia , Transdução de Sinais , Ensaios Antitumorais Modelo de Xenoenxerto
4.
J Enzyme Inhib Med Chem ; 35(1): 265-279, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31790602

RESUMO

Benzothiazole (BTA) belongs to the heterocyclic class of bicyclic compounds. BTA derivatives possesses broad spectrum biological activities such as anticancer, antioxidant, anti-inflammatory, anti-tumour, antiviral, antibacterial, anti-proliferative, anti-diabetic, anti-convulsant, analgesic, anti-tubercular, antimalarial, anti-leishmanial, anti-histaminic and anti-fungal among others. The BTA scaffolds showed a crucial role in the inhibition of the metalloenzyme carbonic anhydrase (CA). In this review an extensive literature survey over the last decade discloses the role of BTA derivatives mainly as anticancer agents. Such compounds are effective against various types of cancer cell lines through a multitude of mechanisms, some of which are poorly studied or understood. The inhibition of tumour associated CAs by BTA derivatives is on the other hand better investigated and such compounds may serve as anticancer leads for the development of agents effective against hypoxic tumours.


Assuntos
Antineoplásicos/farmacologia , Benzotiazóis/farmacologia , Neoplasias/tratamento farmacológico , Antineoplásicos/síntese química , Antineoplásicos/química , Benzotiazóis/síntese química , Benzotiazóis/química , Linhagem Celular , Proliferação de Células/efeitos dos fármacos , Relação Dose-Resposta a Droga , Humanos , Estrutura Molecular , Neoplasias/metabolismo , Neoplasias/patologia , Relação Estrutura-Atividade
5.
Expert Opin Ther Pat ; 30(1): 15-25, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31847622

RESUMO

Introduction: Worldwide, the annual expenditure on anticancer drugs is grossly calculated to be in the order of US$100 billion, and is expected to escalate up to $150 billion by 2020. It is evident that the vast majority of the most recently devised anticancer drugs are unaffordable in economically developing nations, frequently resulting in subpar therapies. In this complex medical and economic scenario, the repurposing of older drugs for anticancer therapies becomes a necessity. The repurposing of antiacid drugs such as the proton pump inhibitors as antitumoral agents and chemosensitizers is probably one of the most recent and promising phenomenon in oncology.Areas covered: Important research articles and patents focusing on proton pump inhibitors as a potential class of therapeutics, published between the period of 2006-2019, have been covered. This review mainly focuses on the therapeutic applications, as direct anticancer agents as well as modifiers of the tumor microenvironment and modulator of chemoresistance.Expert opinion: PPIs have significant anticancer applications and are proving to be safe, effective and inexpensive. Here the authors review the current knowledge regarding the influence of PPIs on the efficacy and safety of cancer chemotherapeutics through the regulation of targets other than the H+/K+-ATPase.


Assuntos
Antineoplásicos/farmacologia , Reposicionamento de Medicamentos , Inibidores da Bomba de Prótons/farmacologia , Animais , Antineoplásicos/administração & dosagem , Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos , Humanos , Neoplasias/tratamento farmacológico , Patentes como Assunto , Inibidores da Bomba de Prótons/administração & dosagem , Microambiente Tumoral/efeitos dos fármacos
7.
Soins ; 64(841): 20-21, 2019 Dec.
Artigo em Francês | MEDLINE | ID: mdl-31864506

RESUMO

Oral chemotherapy is a therapy which is increasingly prescribed in outpatient care but which should not be trivialised. The patient must be given information and education to ensure compliance and awareness of the side effects to share with the care team as soon as they appear.


Assuntos
Neoplasias/tratamento farmacológico , Administração Oral , Humanos
8.
Soins ; 64(841): 30-33, 2019 Dec.
Artigo em Francês | MEDLINE | ID: mdl-31864509

RESUMO

With around 1 800 new cases each year in children under the age of 15 and 800 new cases a year in teenagers, childhood cancers are a major public health issue. Chemotherapy remains a key component in the treatment of childhood cancers but the advances made in genetics has opened the way to targeted therapies which enable the treatment to be adapted to each child significantly improving survival and reducing sequelae.


Assuntos
Oncologia/organização & administração , Neoplasias/tratamento farmacológico , Pediatria/organização & administração , Adolescente , Criança , Humanos
9.
Soins ; 64(841): 34-37, 2019 Dec.
Artigo em Francês | MEDLINE | ID: mdl-31864510

RESUMO

Beyond the recommendations of the French directorate general for healthcare provision encouraging hospitals to find alternatives to conventional hospitalisation for their patients, hospital at home care is appreciated by patients for the comfort it enables them to maintain in the continuation of their cancer treatment. It is also increasingly favoured by oncologists who can be assured of the continuity of their protocols by a nursing community with expertise in chemotherapy.


Assuntos
Serviços de Assistência Domiciliar , Neoplasias/tratamento farmacológico , França , Humanos
10.
Soins ; 64(841): 40-45, 2019 Dec.
Artigo em Francês | MEDLINE | ID: mdl-31864512

RESUMO

Located across three sites in Ile-de-France, the Institut Curie combines care, research and teaching activities to fight cancer. Faced with the progression of ambulatory care, the departments have had to adapt in order to improve patient support and oversee community-hospital coordination. Nurses become involved just after the disclosure of the diagnosis by the doctor, but also coordinate the patient's pathway in ambulatory care. They anticipate the needs of the teams, the patients and their carers. Patients appreciate their availability and the fact that they have a single contact person.


Assuntos
Hospital Dia , Neoplasias/tratamento farmacológico , França , Humanos
11.
Soins ; 64(841): 50-51, 2019 Dec.
Artigo em Francês | MEDLINE | ID: mdl-31864514

RESUMO

Beyond the checking of a prescription, the pathophysiological characteristics of the patient and the other prescribed medicines, pharmacists contribute to the field of oncology in their other missions. The benefits in terms of the reduction of risks for caregivers have been favoured by the centralisation of preparations combined with the application of other methods derived from industry. Research is continuing in order to dispense safe medicines which comply with the prescription and control the risks linked to the use of these highly active medicines.


Assuntos
Cuidadores/psicologia , Relações Interprofissionais , Neoplasias/tratamento farmacológico , Farmacêuticos/psicologia , Humanos
12.
Biomed Khim ; 65(6): 507-512, 2019 Oct.
Artigo em Russo | MEDLINE | ID: mdl-31876521

RESUMO

Cytotoxic and photoinduced activity of chlorine e6 (Ce6) in phospholipid nanoparticles with specific tumor targeting and cell-penetrating peptides was studied in vitro using human fibrosarcoma cells HT-1080. It was shown, that the binding of cell-penetrating peptide R7 - alone or combined with the peptide containing specific targeting motif NGR (Asn-Gly-Arg) - resulted in 3-fold decrease of Ce6 photoinduced activity as compared with that in nanoparticles without peptides (IC50 values were 0.7 µg/ml and 2.1 µg/ml, respectively). The NGR influence was unexpectedly low - less than 20% (IC50 1.7 µg/ml). This suggests the more importance of Ce6 cell penetration in this case, than of NGR-mediated targeting. The effect of inclusion of both peptides on the total cytotoxicity of Ce6 was minimal (10-16 times less than on the specific photoinduced activity). The obtained results - together with earlier shown effects on improvement of the pharmacokinetics of Ce6 in vivo after its embedding into phospholipid nanoparticles - indicate the prospects of using the obtained phospholipid nanoparticles system for photodynamic therapy.


Assuntos
Nanopartículas , Neoplasias/tratamento farmacológico , Peptídeos/farmacologia , Fotoquimioterapia , Porfirinas/química , Linhagem Celular Tumoral , Humanos , Fármacos Fotossensibilizantes
13.
J Photochem Photobiol B ; 201: 111648, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31710924

RESUMO

Superparamagnetic iron oxide nanoparticles (SPIONs) have been recently recognized as highly efficient photothermal therapy (PTT) agents. Here, we demonstrate, for the first time to our knowledge, dose and laser intensity dependent PTT potential of small, spherical, 3-aminopropyltrimethoxysilane coated cationic superparamagnetic iron oxide nanoparticles (APTMS@SPIONs) in aqueous solutions upon irradiation at 795 nm. Indocyanine green (ICG) which has been recently used for photodynamic therapy (PDT), was loaded to APTMS@SPIONs to improve the stability of ICG and to achieve an effective mild PTT and PDT (dual therapy) combination for synergistic therapeutic effect on cancer cells via a single laser treatment in the near infrared (NIR). Neither APTMS@SPIONs nor ICG-APTMS@SPIONs showed dark toxicity on MCF7 breast and HT29 colon cancer cell lines. A safe laser procedure was determined as 10 min irradiation at 795 nm with 1.8 W/cm2 of laser intensity, at which APTMS@SPION did not cause a significant cell death. However, free ICG reduced cell viability at and above 10 µg/ml under these conditions along with generation of reactive oxygen species (ROS), more effectively in MCF7. ICG-APTMS@SPION treated cells showed 2-fold increase in ROS generation and near complete cell death at and below 5 µg/ml ICG dose, even in less sensitive HT29 cells after a single laser treatment at NIR, which would be safe for the healthy tissue and provide a longer penetration depth. Besides, both components can be utilized for diagnosis and the overall composition may be used for optical-image guided phototherapy in the NIR region.


Assuntos
Verde de Indocianina/química , Nanopartículas de Magnetita/toxicidade , Propilaminas/química , Silanos/química , Apoptose/efeitos dos fármacos , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Humanos , Verde de Indocianina/farmacologia , Raios Infravermelhos , Nanopartículas de Magnetita/química , Nanopartículas de Magnetita/uso terapêutico , Neoplasias/tratamento farmacológico , Neoplasias/patologia , Neoplasias/terapia , Fotoquimioterapia , Fototerapia , Espécies Reativas de Oxigênio/metabolismo , Temperatura Ambiente
15.
Adv Exp Med Biol ; 1168: 91-101, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31713166

RESUMO

The rapid advancements of treatment modalities and vast amounts of information being generated through novel technologies, paint the picture of a very promising future, one that will allow for a more efficient and precise DNA sequencing and potentially more tailored cancer therapies for patients. However, with all these advances we must address the ethical and legal considerations each one of these technologies will raise. This is a necessity in order for advancement, not to stand in the way of science and development, but as a safeguard in protecting humanity and our personal genetic information.


Assuntos
Neoplasias , Farmacogenética , Registros de Saúde Pessoal/ética , Humanos , Neoplasias/tratamento farmacológico , Neoplasias/genética , Farmacogenética/ética
16.
Isr Med Assoc J ; 21(11): 710-715, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31713356

RESUMO

BACKGROUND: The policies and practices related to medical cannabis are currently in flux. These changes have been associated with many controversies, and there is a lack of consensus within the medical community regarding medical cannabis practices. OBJECTIVES: To validate clinical vignettes that can be used to examine and improve medical cannabis practices. METHODS: Ten physicians participated in a Delphi survey of two consequent rounds in which they quantified the eligibility of medical cannabis therapy for six clinical vignettes describing both chronic pain and cancer patients. RESULTS: Higher consensus was achieved for the vignettes of cancer patients, which were additionally rated as more eligible for medical cannabis therapy. The highest level of consent (4.3 out of 5) was achieved regarding a vignette of a metastatic cancer patient. While in some cases physicians consolidated their ratings toward the group's average, in other cases they remained stable in their responses. CONCLUSIONS: While controversies related to medical cannabis are expected to remain rampant, the validated vignettes may facilitate assessment of clinical practices, which is essential for a successful implementation of medical cannabis policies. These vignettes may additionally be used in medical training for appropriate patient selection for medical cannabis authorization.


Assuntos
Dor do Câncer/tratamento farmacológico , Dor Crônica/tratamento farmacológico , Tomada de Decisão Clínica , Maconha Medicinal , Neoplasias/tratamento farmacológico , Técnica Delfos , Humanos , Israel
17.
Adv Exp Med Biol ; 1182: 39-77, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31777014

RESUMO

The antitumor effect of Ganoderma (Lingzhi) is closely related to immunoregulation. Based on our research and other references, this article discussed the antitumor effect of Ganoderma mediated by immunological mechanism, including promoting the function of mononuclear-macrophages and natural killers; promoting M1-type macrophage polarization vs M2-type; promoting maturation and differentiation of dendritic cells, increasing its antigen presentation, activating lymphocytes and increasing cytotoxicity of cytotoxin T lymphocyte; promoting production of cytokines; and inhibiting tumor escape from immune surveillance. Also, clinical studies with immunological indexes were reviewed.


Assuntos
Antineoplásicos/farmacologia , Produtos Biológicos/farmacologia , Imunomodulação , Neoplasias/tratamento farmacológico , Reishi/química , Apresentação do Antígeno , Diferenciação Celular , Citocinas/imunologia , Células Dendríticas/imunologia , Humanos , Macrófagos/imunologia , Linfócitos T/imunologia
18.
Adv Exp Med Biol ; 1182: 79-118, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31777015

RESUMO

The anticancer potential of Ganoderma (Lingzhi) and its extracts has been widely demonstrated, including antiproliferative and apoptosis inductive, antimetastatic, antiangiogenic, and multidrug resistance reversional activities, involving a variety of cellular and molecular mechanisms besides antitumor immunology. Intrinsic- and extrinsic-initiated apoptotic pathway in association with cell cycle arresting, telomerase inhibiting, autophagy, and oxidative stress is involved in the antiproliferative and apoptosis inductive activities of Ganoderma and its extracts. The inhibition of tumor cell adhesion, invasion, and migration by Ganoderma and its extracts involves molecular mechanisms such as AP-1, NF-κB, MMP, cadherin, ß-integrin, c-Met, FAK, EMT, and so on. Targeting the major pro-angiogenic stimulus, VEGF, and its receptor contributes to the inhibition of tumor angiogenesis by Ganoderma and its extracts. Inhibition against the ATP-dependent transmembrane drug transporter such as P-glycoprotein (P-gp) on the surface of resistant tumor cells to prevent reduction of the intracellular accumulation of anticancer drugs by pumping out the drugs plays an important role in the activities of Ganoderma and its extracts to reverse tumor cell multidrug resistance.


Assuntos
Antineoplásicos/farmacologia , Produtos Biológicos/farmacologia , Neoplasias/tratamento farmacológico , Reishi/química , Membro 1 da Subfamília B de Cassetes de Ligação de ATP/metabolismo , Apoptose , Linhagem Celular Tumoral , Resistência a Múltiplos Medicamentos , Resistencia a Medicamentos Antineoplásicos , Humanos
19.
Adv Exp Med Biol ; 1182: 119-142, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31777016

RESUMO

Radiation and chemotherapy are common and mainstay treatments for cancer patients. But they are also usually associated with some toxicity and side effects in most of the patients. Ganoderma (Lingzhi) is considered as a major kind of complementary/alternative medicine and used to prevent the adverse effects caused by radiation and chemotherapy. This chapter reviewed the protective effects of Ganoderma (Lingzhi) on radiation and chemotherapy, including the preventive effects on myelosuppression, intestinal injury, nephrotoxicity, cardiovascular toxicity, and other side effects. Both basic researches and clinical studies of Ganoderma (Lingzhi) in preventing side effects induced by radiation and chemotherapy were reviewed.


Assuntos
Produtos Biológicos/farmacologia , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/prevenção & controle , Neoplasias/tratamento farmacológico , Neoplasias/radioterapia , Protetores contra Radiação/farmacologia , Reishi/química , Humanos
20.
Mini Rev Med Chem ; 19(15): 1219-1254, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31735158

RESUMO

Nowadays, heterocyclic compounds act as a scaffold and are the backbone of medicinal chemistry. Among all of the heterocyclic scaffolds, 1,4-Dihydropyridine (1,4-DHP) is one of the most important heterocyclic rings that possess prominent therapeutic effects in a very versatile manner and plays an important role in synthetic, medicinal, and bioorganic chemistry. The main aim of the study is to review and encompass relevant studies related to 1,4-DHP and excellent therapeutic benefits of its derivatives. An extensive review of Pubmed-Medline, Embase and Lancet's published articles was done to find all relevant studies on the activity of 1,4-DHP and its derivatives. 1,4-DHP is a potent Voltage-Gated Calcium Channel (VGCC) antagonist derivative which acts as an anti-hypertensive, anti- anginal, anti-tumor, anti-inflammatory, anti-tubercular, anti-cancer, anti-hyperplasia, anti-mutagenic, anti-dyslipidemic, and anti-ulcer agent. From the inferences of the study, it can be concluded that the basic nucleus, 1,4-DHP which is a voltage-gated calcium ion channel blocker, acts as a base for its derivatives that possess different important therapeutic effects. There is a need of further research of this basic nucleus as it is a multifunctional moiety, on which addition of different groups can yield a better drug for its other activities such as anti-convulsant, anti-oxidant, anti-mutagenic, and anti-microbial. This review would be significant for further researches in the development of several kinds of drugs by representing successful matrix for the medicinal agents.


Assuntos
Di-Hidropiridinas/farmacologia , Compostos Heterocíclicos/farmacologia , Neoplasias/tratamento farmacológico , Anti-Inflamatórios não Esteroides/química , Anti-Inflamatórios não Esteroides/farmacologia , Antiulcerosos/química , Antiulcerosos/farmacologia , Anti-Hipertensivos/química , Anti-Hipertensivos/farmacologia , Antineoplásicos/química , Antineoplásicos/farmacologia , Bloqueadores dos Canais de Cálcio/química , Bloqueadores dos Canais de Cálcio/farmacologia , Canais de Cálcio/metabolismo , Di-Hidropiridinas/química , Compostos Heterocíclicos/química , Úlcera/tratamento farmacológico
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