Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 1.212
Filtrar
4.
J Invest Dermatol ; 140(1): 164-173.e7, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31580842

RESUMO

The use of microRNAs as biomarkers has been proposed for many diseases, including the diagnosis of melanoma. Although hundreds of microRNAs have been identified as differentially expressed in melanomas as compared to benign melanocytic lesions, a limited consensus has been achieved across studies, constraining the effective use of these potentially useful markers. In this study, we applied a machine learning-based pipeline to a dataset consisting of genetic features, clinical features, and next-generation microRNA sequencing from micro-dissected formalin-fixed paraffin embedded melanomas and their adjacent benign precursor nevi. We identified patient age and tumor cellularity as variables that frequently confound the measured expression of potentially diagnostic microRNAs. By employing the ratios of microRNAs that were either enriched or depleted in melanoma compared to the nevi as a normalization strategy, we developed a model that classified all the available published cohorts with an area under the receiver operating characteristic curve of 0.98. External validation on an independent cohort classified lesions with 81% sensitivity and 88% specificity and was uninfluenced by the tumor content of the sample or patient age.


Assuntos
Biomarcadores Tumorais/genética , Melanócitos/fisiologia , Melanoma/diagnóstico , MicroRNAs/genética , Nevo/diagnóstico , Neoplasias Cutâneas/diagnóstico , Conjuntos de Dados como Assunto , Diagnóstico Diferencial , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Aprendizado de Máquina , Prognóstico , Curva ROC , Sensibilidade e Especificidade , Análise de Sequência de RNA
5.
J Am Acad Dermatol ; 82(3): 622-627, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31306724

RESUMO

BACKGROUND: Computer vision has promise in image-based cutaneous melanoma diagnosis but clinical utility is uncertain. OBJECTIVE: To determine if computer algorithms from an international melanoma detection challenge can improve dermatologists' accuracy in diagnosing melanoma. METHODS: In this cross-sectional study, we used 150 dermoscopy images (50 melanomas, 50 nevi, 50 seborrheic keratoses) from the test dataset of a melanoma detection challenge, along with algorithm results from 23 teams. Eight dermatologists and 9 dermatology residents classified dermoscopic lesion images in an online reader study and provided their confidence level. RESULTS: The top-ranked computer algorithm had an area under the receiver operating characteristic curve of 0.87, which was higher than that of the dermatologists (0.74) and residents (0.66) (P < .001 for all comparisons). At the dermatologists' overall sensitivity in classification of 76.0%, the algorithm had a superior specificity (85.0% vs. 72.6%, P = .001). Imputation of computer algorithm classifications into dermatologist evaluations with low confidence ratings (26.6% of evaluations) increased dermatologist sensitivity from 76.0% to 80.8% and specificity from 72.6% to 72.8%. LIMITATIONS: Artificial study setting lacking the full spectrum of skin lesions as well as clinical metadata. CONCLUSION: Accumulating evidence suggests that deep neural networks can classify skin images of melanoma and its benign mimickers with high accuracy and potentially improve human performance.


Assuntos
Aprendizado Profundo , Dermoscopia/métodos , Interpretação de Imagem Assistida por Computador/métodos , Melanoma/diagnóstico , Neoplasias Cutâneas/diagnóstico , Colômbia , Estudos Transversais , Dermatologistas/estatística & dados numéricos , Dermoscopia/estatística & dados numéricos , Diagnóstico Diferencial , Humanos , Cooperação Internacional , Internato e Residência/estatística & dados numéricos , Israel , Ceratose Seborreica/diagnóstico , Melanoma/patologia , Nevo/diagnóstico , Curva ROC , Pele/diagnóstico por imagem , Pele/patologia , Neoplasias Cutâneas/patologia , Espanha , Estados Unidos
6.
J Dtsch Dermatol Ges ; 18(1): 27-32, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31671255

RESUMO

BACKGROUND AND OBJECTIVES: Dermatoscopy may be hindered by body hair, and the development of an automated hair removal algorithm (AuHRA) might improve the diagnostic accuracy. However, the physicians' exact level of hindrance and the clinical benefit attained by AuHRA has not been assessed. The objectives of this study are to quantify the physicians' level of hindrance by body hair and the level of improvement in the visibility of underlying dermatoscopic patterns after application of AuHRA to digital images of hair-covered nevi. PATIENTS AND METHODS: A cross-sectional reader study including 59 sets of dermatoscopic images of benign nevi that were presented to six dermatologists. Each set included three images of one individual nevus (unshaved/physically shaved/digitally shaved with AuHRA), which were compared to each other within each set to assess the level of improvement caused by hair removal. RESULTS: In comparison to unshaved lesions, dermatologists attributed the highest mean level of improvement to a physical shave (+1.36, p < 0.001) followed by AuHRA's digital shave (+0.79, p < 0.001). The majority of dermatologists considered the application of AuHRA as helpful and confirmed a medical need. CONCLUSIONS: The dermatologists in our study confirmed a substantial impairment of the dermatoscopic examination by body hair. We demonstrated a clinical benefit attained by AuHRA in comparison to unshaved or physically shaved lesions.


Assuntos
Algoritmos , Remoção de Cabelo/métodos , Nevo/diagnóstico , Neoplasias Cutâneas/diagnóstico , Estudos Transversais , Dermoscopia/métodos , Diagnóstico Diferencial , Humanos , Exame Físico
7.
J Cutan Pathol ; 47(3): 226-240, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31697431

RESUMO

PURPOSE: Distinguishing benign nevi from malignant melanoma using current histopathological criteria may be very challenging and is one the most difficult areas in dermatopathology. The goal of this study was to identify proteomic differences, which would more reliably differentiate between benign and malignant melanocytic lesions. METHODS: We performed histolpathology - guided mass spectrometry (HGMS) profiling analysis on formalin-fixed, paraffin embedded tissue samples to identify differences at the proteomic level between different types of benign nevi and melanomas. A total of 756 cases, of which 357 cases of melanoma and 399 benign nevi, were included in the study. The specimens originated from both biopsies (376 samples) and tissue microarray (TMA) cores (380 samples). After obtaining mass spectra from each sample, classification models were built using a training set of biopsy specimens from 111 nevi and 100 melanomas. The classification algorithm developed on the training data set was validated on an independent set of 288 nevi and 257 melanomas from both biopsies and TMA cores. RESULTS: In the melanoma cohort, 239/257 (93%) cases classified correctly in the validation set, 3/257 (1.2%) classified incorrectly, and 15/257 (5.8%) classified as indeterminate. In the cohort of nevi, 282/288 (98%) cases classified correctly, 1/288 (0.3%) classified incorrectly, and 5/288 (1.7%) were indeterminate. HGMS showed a sensitivity of 98.76% and specificity of 99.65% in determining benign vs malignant. CONCLUSION: HGMS proteomic analysis is an objective and reliable test with minimal tissue requirements, which can be a helpful ancillary test in the diagnosis of challenging melanocytic lesions.


Assuntos
Aprendizado de Máquina , Espectrometria de Massas/métodos , Melanoma/diagnóstico , Nevo/diagnóstico , Neoplasias Cutâneas/diagnóstico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Proteômica/métodos , Adulto Jovem
8.
Am J Surg Pathol ; 44(3): 357-367, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-31743128

RESUMO

The accurate recognition of subtle melanomas and their distinction from benign mimics is an oft-recurring diagnostic problem, critical for patient management. Melanomas that bear resemblance to benign nevi (so-called nevoid melanomas, NMs) and benign mitotically active nevi in pregnancy (MANP) are 2 lesions particularly prone to error. Molecular data, including analysis of noncoding regions, in MANP and NM are very limited. This study sought to identify differences in clinical, pathologic, and molecular characteristics between MANP and NMs to facilitate correct diagnosis and reduce the risk of overtreatment or undertreatment. Clinicopathologic characteristics of NM (n=18) and MANP (n=30) were evaluated, and mutation data were analyzed using next-generation sequencing for available cases in each group (NM, n=8; MANP, n=12). All MANP showed innocent histopathologic characteristics apart from increased mitotic activity, frequently in both superficial and deep parts of the lesion (median dermal mitotic rate: 2/mm, range: 1 to 7/mm). All cases of NM demonstrated a characteristic nevoid silhouette, subtle atypical architectural and cytologic features, and variable mitoses (median mitotic rate: 3/mm, range: 1 to 5/mm). Median NM tumor thickness was 1.4 mm. Four of 10 NM patients with follow-up had metastatic disease, including 3 patients who developed widespread metastases, with 1 disease-related death. No other recurrences have been identified (follow-up period: 24 to 60 mo). None of the 15 MANP patients with available follow-up had a recurrence. Most NMs harbored hotspot mutations in NRAS (6/8, 75%). Noncoding mutations were significantly more common in NMs than in MANP (median: 4 vs. 0, P=0.0014). Copy number alterations were infrequent but, when present, were seen in NMs (3/8 NMs vs. 0/12 MANP). All NMs but only 1 of 12 MANP had >1 abnormality in the noncoding regions. Similar to conventional common acquired nevi, MANP mostly harbored driver BRAF mutations, while activating NRAS mutations, noncoding mutations, and copy number alterations were rare. NM and MANP have subtle but recognizable distinguishing histopathologic characteristics that are underpinned by molecular differences. Mutation analysis of targeted noncoding mutations may assist in the diagnosis of difficult lesions.


Assuntos
Biomarcadores Tumorais/genética , Melanoma/diagnóstico , Mutação , Nevo/diagnóstico , Complicações Neoplásicas na Gravidez/diagnóstico , Neoplasias Cutâneas/diagnóstico , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Erros de Diagnóstico , Feminino , Seguimentos , Perfilação da Expressão Gênica , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Masculino , Melanoma/genética , Melanoma/patologia , Pessoa de Meia-Idade , Nevo/genética , Nevo/patologia , Gravidez , Complicações Neoplásicas na Gravidez/genética , Complicações Neoplásicas na Gravidez/patologia , Neoplasias Cutâneas/genética , Neoplasias Cutâneas/patologia , Adulto Jovem
9.
Dermatol Ther ; 33(1): e13205, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31872489

RESUMO

Atypical nevi are dynamic lesions and may progressively transform into more or less atypical lesions. We aimed to investigate the dermoscopic features of atypical nevi and dynamic changes in these lesions over a period of 3-years. Patients with 3-year dermoscopic follow-up records were enrolled in the study. We compared the dermatoscopic features of the nevus recorded in the first dermoscopic examination and at the end of the third year. Changes in size (mm), pattern, and color were investigated. The most common dermoscopic patterns were reticular (18 patients; 34%), reticular-homogeneous (17 patients; 32.1%), and reticular-globular (7 patients; 13.2%). The most common pigmentation patterns were central hyperpigmentation (28 patients; 52.8%), regular pigmentation (nine patients; 17.0%), and multifocal hypo/hyperpigmentation (eight patients; 15.1%). Twenty-one (39.6%) patients showed changes in pattern. The transformation from reticular-homogeneous pattern to the homogeneous pattern was the most frequent change in pattern (7 of 21 patients; 33.3%). The transformation from reticular pattern to reticular-homogeneous pattern was the second most common change in pattern (5 of 21 patients; 23.8%). Fourteen (26.4%) patients experienced symmetrical enlargement. Symmetrical enlargement was statistically more frequent in patients who showed dermoscopic changes in pattern than in those who did not show any changes in the pattern (p: .038). In this study, we did not observe any new dermoscopic clues for the diagnosis of melanoma during the follow-up. The nevi tended to turn into a homogeneous (structureless) pattern. We observed that the most common dermoscopic change in pattern was the transformation from reticular-homogeneous pattern to homogeneous pattern, and the lesions had symmetrical enlargement during this transformation. In conclusion, despite the known association between atypical nevi and the risk of developing melanoma, most atypical nevi do not transform into melanoma. Therefore, our study suggests that the excision of atypical nevi is not necessary and dermatoscopic follow-up can reduce the number of unnecessary excisions.


Assuntos
Dermoscopia , Melanoma/diagnóstico , Nevo/diagnóstico , Neoplasias Cutâneas/diagnóstico , Adulto , Feminino , Seguimentos , Humanos , Masculino , Melanoma/patologia , Pessoa de Meia-Idade , Nevo/patologia , Estudos Retrospectivos , Neoplasias Cutâneas/patologia
11.
Aust J Gen Pract ; 48(9): 621-624, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31476830

RESUMO

BACKGROUND: As a result of the rapidly changing hormonal milieu, changing or newly discovered pigmented skin lesions during pregnancy can be diagnostically challenging. It is important for GPs to be aware of the effect of gestational changes on pigment production and features that should raise concern. OBJECTIVE: The aim of this article is to provide an understanding of common changes that may occur in pigmented lesions during pregnancy, features that are of concern and the management of suspected melanoma in pregnant women. DISCUSSION: In pregnant women, changing naevi should be evaluated using conventional ABCDE melanoma diagnostic criteria, and suspicious lesions should not be attributed solely to a change in the hormonal milieu. In this population, diagnosed melanoma is probably best treated at a specialist centre.


Assuntos
Síndrome do Nevo Displásico/diagnóstico , Melanoma/diagnóstico , Melanose/diagnóstico , Nevo Pigmentado/diagnóstico , Complicações Neoplásicas na Gravidez/diagnóstico , Neoplasias Cutâneas/diagnóstico , Dermoscopia , Diagnóstico Diferencial , Síndrome do Nevo Displásico/patologia , Feminino , Medicina Geral , Humanos , Hiperpigmentação/diagnóstico , Melanoma/patologia , Melanose/patologia , Nevo/diagnóstico , Nevo/patologia , Nevo Pigmentado/patologia , Gravidez , Complicações na Gravidez/diagnóstico , Complicações na Gravidez/patologia , Complicações Neoplásicas na Gravidez/patologia , Encaminhamento e Consulta , Neoplasias Cutâneas/patologia
13.
Artigo em Inglês | MEDLINE | ID: mdl-31371346

RESUMO

The clinical diagnostic criteria for Proteus syndrome were defined before the discovery of the AKT1 c.49G>A; p.(Glu17Lys) causal variant and used a combination of general and specific phenotypic attributes that could be combined to make a clinical diagnosis. The most heavily weighted specific criterion was the cerebriform connective tissue nevus (CCTN). Here, we describe two individuals with connective tissue nevi (CTNs) and some general attributes of Proteus syndrome who were found to have mosaic PIK3CA variants. CTNs on the soles of individuals with PIK3CA-related overgrowth typically exhibit thickening of the soft tissues with at most a wrinkled surface, but these two patients had firm plaques with ridges and furrows characteristic of CCTNs, which was histologically confirmed in one. These data show that CCTNs are not specific to Proteus syndrome and that clinicians should be cautious in diagnosing individuals with Proteus syndrome based on the CCTN alone. Rather, a complete evaluation should include careful assessment of other attributes of the diagnostic criteria and, whenever possible, genetic analysis of affected tissue.


Assuntos
Classe I de Fosfatidilinositol 3-Quinases/genética , Nevo/genética , Síndrome de Proteu/genética , Adulto , Classe I de Fosfatidilinositol 3-Quinases/metabolismo , Feminino , Testes Genéticos , Humanos , Masculino , Nevo/diagnóstico , Síndrome de Proteu/diagnóstico , Proteínas Proto-Oncogênicas c-akt , Neoplasias Cutâneas/genética
14.
Med Arch ; 73(3): 201-204, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31404124

RESUMO

Introduction: In nowadays, melanoma is one of the major problems of public health all over the world. In Kosovo, the incidence of melanoma has shown irregular tendency with significant increases and decreases in the last five years. Aim: The aim of this paper was to detect the knowledge level of nursing students in Kosovo's University (AAB University) regarding melanoma and its risk factors; to evaluate their knowledge about the protection and prevention methods of melanoma as one of the main topics of dermatology and major problems of public health worldwide nowadays. Of a great importance, it was to evaluate the necessity of establishing a dermatology course in nursing curricula in Kosovo universities, as nurses have a key role in educating and promoting health in the population. Methods: The training was conducted through slides, photos, videos and a questionnaire was used to collect the data before and after training. Data analysis was run through SPSS program version 20.0. Data were expressed through mean values and standard deviations. T-test, Anova and regression analysis were performed to test the relationship between the protective behaviors, knowledge, personal risk and level of concern. Results: Results indicated a low level of knowledge and a fairly poor protective behavior among the participants. Conclusion: On-going training and enrichment of school curricula emerged as an intervention to increase the awareness of the students toward potential risks of melanoma and ultimate change in the protective behavior.


Assuntos
Comportamentos Relacionados com a Saúde , Conhecimentos, Atitudes e Prática em Saúde , Melanoma/prevenção & controle , Nevo/diagnóstico , Neoplasias Cutâneas/prevenção & controle , Estudantes de Enfermagem/psicologia , Adolescente , Adulto , Dermatologia/educação , Educação em Enfermagem , Feminino , Cor de Cabelo , Humanos , Kosovo , Masculino , Melanoma/etiologia , Fatores de Risco , Autorrelato , Neoplasias Cutâneas/diagnóstico , Neoplasias Cutâneas/etiologia , Adulto Jovem
15.
J Dermatol ; 46(9): 777-781, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31342527

RESUMO

Segmental nevus depigmentosus and segmental vitiligo can be difficult to differentiate from each other. Differential diagnosis of these two diseases is important because they have significantly different prognoses and psychological effects. The purpose of this study is to identify clinical clues that may be helpful in differentiating these two diseases. We enrolled 63 patients with segmental nevus depigmentosus and 149 patients with segmental vitiligo. Sex, age of onset, sites involved, dermatomal distribution, margin of lesion and presence of poliosis were evaluated in both groups. The age of onset was less than 10 years in 96.8% of segmental nevus depigmentosus and 28.9% of segmental vitiligo cases. Trunk (36.5%) and cervical (38.1%) dermatomes were the most commonly involved in segmental nevus depigmentosus and face (67.1%) and trigeminal (64.4%) dermatomes in segmental vitiligo. The average number of dermatomes involved in truncal lesions was different in segmental nevus depigmentosus and segmental vitiligo (2.71 vs 1.62, P = 0.001). Segmental vitiligo on the face, neck and trunk appeared closer to the axis than segmental nevus depigmentosus (P < 0.001). Segmental nevus depigmentosus and segmental vitiligo showed significantly different margins (90.5% and 41.6% serrated, respectively; P < 0.001). We observed clinical differences between patients with segmental nevus depigmentosus and those with segmental vitiligo. Distribution (site, distance to axis, dermatome), vertical width, margin of lesion and presence of poliosis can be helpful in differentiating segmental nevus depigmentosus and segmental vitiligo.


Assuntos
Nevo/diagnóstico , Neoplasias Cutâneas/diagnóstico , Vitiligo/diagnóstico , Adolescente , Adulto , Idade de Início , Criança , Pré-Escolar , Diagnóstico Diferencial , Face , Feminino , Humanos , Lactente , Masculino , Pescoço , Fotografação , Estudos Retrospectivos , Pele/diagnóstico por imagem , Tronco , Adulto Jovem
16.
J Eur Acad Dermatol Venereol ; 33(12): 2291-2295, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31318994

RESUMO

BACKGROUND: Melanoma patients with intra-nodal nevi (INN) and without melanoma metastasis in the sentinel lymph node biopsy (SLNB) are generally treated as patients with negative SLNB. However, diagnosis of INN may be difficult and nodal melanoma metastases may falsely be regarded as INN. OBJECTIVES: Our aim was to evaluate the clinical significance of INN in the SLNB in patients with primary cutaneous melanoma on a nationwide level in The Netherlands by comparing survival between three groups: patients with INN and without nodal melanoma metastasis (INN group), patients without INN and without nodal melanoma metastasis (negative SLNB group) and patients with nodal melanoma metastasis irrespective of INN (positive SLNB group). METHODS: Data were obtained from 'PALGA', the Dutch Nationwide Network and Registry of Histopathology and Cytopathology, yielding a cohort of adults with histologically proven, primary, invasive cutaneous melanoma patients in The Netherlands diagnosed between 2000 and 2014 who underwent SLNB. Clinical and pathological variables were extracted from the pathology text files. Differences between patients with INN, negative SLNB and positive SLNB were analysed using Kaplan-Meier analysis. RESULTS: A total of 11 274 patients were eligible for inclusion. The prevalence of INN in the SLNB was 5.0%. Melanomas with INN had similar median Breslow thickness compared to melanomas with negative SLNB and were more frequently located on trunk and upper limbs and observed in younger patients compared to melanomas with negative and positive SLNB. Overall survival of patients with INN showed no significant difference compared with negative SLNB (median follow-up of 5.7 years of all patients). CONCLUSIONS: As there seems to be no difference in overall survival between patients with INN and negative SLNB, the diagnosis of INN seems to be reliable. Current practice to treat patients with INN as patients with negative SLNB appears to be appropriate.


Assuntos
Melanoma/diagnóstico , Nevo/patologia , Linfonodo Sentinela/patologia , Neoplasias Cutâneas/diagnóstico , Análise de Sobrevida , Adulto , Humanos , Masculino , Melanoma/patologia , Pessoa de Meia-Idade , Nevo/diagnóstico , Neoplasias Cutâneas/patologia
19.
J Eur Acad Dermatol Venereol ; 33(12): 2273-2282, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31283045

RESUMO

BACKGROUND: Negative pigment network (NPN) is a dermoscopic structure observed more frequently among melanomas than naevi. Precise tissue correlates of NPN are still elusive. OBJECTIVE: To describe the reflectance confocal microscopy (RCM) findings underlying NPN in melanocytic neoplasms. METHODS: We retrospectively identified all melanocytic neoplasms displaying dermoscopic NPN that were imaged with RCM and subsequently biopsied between 2011 and 2015. Images from study lesions (n = 50) were evaluated for dermoscopic and RCM Criteria. Histopathological correlational study was performed in a subset of cases (n = 15). RESULTS: The study data set consisted of 21 melanomas (42%) and 29 naevi (58%). Melanomas showed more frequently irregularly shaped globules than naevi (62% vs. 28%, P = 0.03); NPN also tended to be more asymmetrically located among melanomas (86%) than naevi (62%), albeit not significant (P = 0.06). Under RCM, we observed three patterns of dermal papillae (DP): (i) 'Dark DP' - whereby DP were devoid of nests and often surrounded by a junctional proliferation as thick-Rings - this pattern was less common among melanomas (n = 10, 48%) than naevi (n = 23, 79%, P = 0.02); (ii) 'Bulging DP' - whereby junctional nests of melanocytes protrude into the DP, often in association with junctional proliferation as Meshwork - with comparable frequency among melanomas (n = 12, 57%) and naevi (n = 23, 79%, P = 0.09) and (iii) 'Expanded DP' - whereby junctional and/or dermal nests filled and expanded the DP, often in association with dermal-epidermal junction (DEJ) Clod pattern - seen more commonly among melanomas (n = 15, 71%) than naevi (n = 6, 21%, P < 0.001). Dermoscopy-RCM correlation and comparison to histopathological findings show that the hypo-pigmented lines of NPN correlate with broadened epidermal retes, which often show overlying surface dells and wedge-shaped hypergranulosis, while the pigmented globules of NPN correlate with a predominantly-junctiona of melanocytes along and between the elongated retes. CONCLUSIONS: Dermoscopic NPN correlates with three DEJ RCM patterns with differing frequency between naevi and melanomas.


Assuntos
Dermoscopia/métodos , Melanoma/diagnóstico , Melanoma/tratamento farmacológico , Microscopia Confocal/métodos , Nevo/diagnóstico , Neoplasias Cutâneas/diagnóstico , Feminino , Humanos , Masculino , Melanoma/patologia , Nevo/patologia , Neoplasias Cutâneas/patologia
20.
Aust J Gen Pract ; 48(6): 364-367, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31220885

RESUMO

BACKGROUND: Benign pigmented skin lesions are extremely common. Such lesions are seen every day in general practice. OBJECTIVE: The objectives of this paper are to develop a framework that may be used to evaluate pigmented skin lesions and a strategy for dealing with pigmented lesions, outline the conditions that improve the diagnosis of pigmented lesions (eg good lighting, careful inspection and dermoscopy), and increase clinician confidence in identifying pigmented lesions with concerning features. DISCUSSION: Regular assessment of pigmented skin lesions during patient consultations, including in an opportunistic fashion, will increase diagnostic acumen and help to identify potentially problematic lesions, and may improve patient awareness of lesions on their skin.


Assuntos
Transtornos da Pigmentação/diagnóstico , Biópsia/métodos , Doença de Bowen/diagnóstico , Doença de Bowen/diagnóstico por imagem , Humanos , Ceratose Seborreica/diagnóstico , Ceratose Seborreica/diagnóstico por imagem , Nevo/diagnóstico , Nevo/diagnóstico por imagem , Exame Físico/métodos , Transtornos da Pigmentação/diagnóstico por imagem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA