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1.
Medicine (Baltimore) ; 98(45): e17913, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31702669

RESUMO

Nocardia is an opportunistic pathogen from environment, which is generally thought to infect immunosuppressed patients (ISPs), but recent studies showed it could also cause infections in immunocompetent patients (ICPs).The aim of this study was to compare the clinical characteristics, patients' outcome, Nocardia species' identification, and antibiotic susceptibility profiles of nocardiosis between ICPs and ISPs.The detailed clinical data were collected from all the nonrepetitive nocardiosis patients during 2011 and 2018, from a tertiary general hospital in Beijing, China. Then each Nocardia isolate was identified to species level by DNA sequencing. The antibiotic susceptibility testing was performed by E test method, and interpreted following CLSI M24 document. The clinical and microbiological characteristics between ICPs and ISPs were compared statistically.A total of 23 nonrepetitive nocardiosis patients with detailed clinical data were enrolled in this study. Among them, 9 were ICPs and 14 were ISPs. All the skin and soft tissue infections occurred in ICPs (33.3% vs 0%, P < .05). Bronchiectasis occurred more frequently in ICPs (44.4% vs 21.4%), whereas chronic kidney diseases and coinfection with aspergillosis occurred more frequently in ISPs (35.7% vs 0%, 35.7% vs 0%, respectively), although they did not reach the statistical significance. There were no significant differences in other clinical characteristics, Nocardia species' identification, and antibiotic susceptibility between ISPs and ICPs (P > .05).Nocardiosis could occur in both ISPs and ICPs. Skin and soft tissue infection and bronchiectasis occurred more frequently in ICPs. Chronic kidney diseases and co-infection with aspergillosis occurred more frequently in ISPs. These characteristics should be noticed by physicians in diagnosis of nocardiosis.


Assuntos
Imunocompetência , Nocardiose/microbiologia , Nocardia/isolamento & purificação , Adulto , Idoso , Antibacterianos/uso terapêutico , China/epidemiologia , Feminino , Humanos , Masculino , Testes de Sensibilidade Microbiana/estatística & dados numéricos , Pessoa de Meia-Idade , Nocardia/efeitos dos fármacos , Nocardiose/classificação , Nocardiose/diagnóstico , Nocardiose/epidemiologia , Estudos Retrospectivos , Centros de Atenção Terciária/estatística & dados numéricos
2.
BMC Infect Dis ; 19(1): 953, 2019 Nov 08.
Artigo em Inglês | MEDLINE | ID: mdl-31703558

RESUMO

BACKGROUND: Localized `and disseminated Nocardia farcinica infection is frequently reported in immunocompromised patients. However, orbital nocardiosis is rare, and, to our knowledge, traumatic orbital nocardiosis that affects the brain has never been described. Here, we report a case of traumatic orbital and intracranial N. farcinica infection in an immunocompetent patient. CASE PRESENTATION: A 35-year-old man, who was immunocompetent, to the best of our knowledge and as per the absence of immunodeficiency symptoms, with orbital trauma caused by the penetration of a rotten bamboo branch developed lesions in the orbit and brain. Subsequently, he underwent debridement and received broad-spectrum antibiotic therapy, but orbital infection occurred, with drainage of pus through the sinus tract. The patient then underwent endoscope-assisted local debridement. Bacterial culture of the sinusal pus was positive for N. farcinica, and a combined intracranial infection had developed. The disease was treated effectively by trimethoprim-sulfamethoxazole and ceftriaxone sodium therapy. The patient remained infection free and without complications at the 14-month follow-up. CONCLUSIONS: Traumatic orbital and intracranial infection caused by N. farcinica is a rare infectious disease, and atypical presentations easily lead to misdiagnosis. When a patient presents with an atypical orbital infection that is unresponsive to empirical broad-spectrum antibiotics, along with suspicious neurologic symptoms, Nocardia infection should be considered. Identification by bacterial culture is the gold standard. Complete local debridement and appropriate antibiotic treatment are keys to the treatment of the disease.


Assuntos
Ferimentos Oculares Penetrantes/microbiologia , Nocardiose/diagnóstico , Nocardiose/microbiologia , Nocardia/isolamento & purificação , Órbita/lesões , Adulto , Antibacterianos/uso terapêutico , Ceftriaxona/uso terapêutico , Desbridamento , Drenagem , Seguimentos , Humanos , Hospedeiro Imunocomprometido , Masculino , Nocardiose/tratamento farmacológico , Nocardiose/cirurgia , Doenças Raras/diagnóstico , Doenças Raras/tratamento farmacológico , Doenças Raras/microbiologia , Doenças Raras/cirurgia , Sasa/microbiologia , Resultado do Tratamento , Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
3.
Indian J Pathol Microbiol ; 62(4): 621-623, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31611456

RESUMO

Nocardia spp. are filamentous Gram positive bacteria that are ubiquitous soil saprophytes. The majority of nocardial infections occur in severely immunocompromised patients who are particularly susceptible to pulmonary disease and dissemination. Extrapulmonary nocardiosis is relatively common and can occur through hematogenous dissemination or a contiguous spread of necrotizing pneumonitis. Primary cutaneous and soft tissue nocardiosis can result from traumatic injury to the skin that involves contamination with soil. After skin inoculation, a superficial abscess or localized cellulitis can develop. Co-trimoxazole is the drug of choice for all types of nocardiosis. We are reporting a case of Nocardia cyriacigeorgica presenting as cellulitis followed tooth extraction.


Assuntos
Celulite (Flegmão)/patologia , Nocardiose/diagnóstico , Abscesso/microbiologia , Abscesso/patologia , Antibacterianos/uso terapêutico , Humanos , Masculino , Pessoa de Meia-Idade , Nocardia/efeitos dos fármacos , Nocardiose/tratamento farmacológico , Extração Dentária/efeitos adversos , Resultado do Tratamento
4.
Arq. bras. med. vet. zootec. (Online) ; 71(5): 1518-1524, set.-out. 2019. tab, ilus
Artigo em Português | LILACS, VETINDEX | ID: biblio-1038661

RESUMO

Nocardiose é causada por bactérias do gênero Nocardia do subgrupo Actinomycetos, que são Gram-positivas aeróbicas, filamentosas e podem apresentar ramificações. O diagnóstico baseia-se na presença de lesão inflamatória, com o microrganismo morfologicamente compatível, associada ao isolamento e à identificação microbiológica e molecular. Este trabalho tem por objetivo relatar um caso de nocardiose em canino, que desenvolveu inflamação piogranulomatosa peritoneal seis meses após ovariossalpingo-histerectomia. O animal apresentava hipertermia, distensão abdominal, taquipneia, polidipsia, hiporexia, mucosas hipocoradas e fezes pastosas. Os achados laboratoriais evidenciaram anemia leve e leucocitose por neutrofilia com desvio à esquerda e hipoalbuminemia. Uma massa na região mesogástrica e efusão peritoneal foram evidenciadas por meio da ultrassonografia abdominal. O líquido foi classificado como exsudato piogranulomatoso, e o animal submetido à laparotomia exploratória para lavagem abdominal e remoção da massa. Após procedimentos terapêuticos, ocorreu piora clínica e óbito. Peritonite piogranulomatosa foi a principal alteração anatomopatológica a qual foi associada à Nocardia spp. Molecularmente, a espécie isolada se aproxima da N. concava, por meio da análise filogenética. Essa espécie já foi descrita como causa de infecção em humanos na Ásia, no entanto não há registros na literatura na espécie canina, sendo este o primeiro relato.(AU)


Nocardiosis is caused by an aerobic, gram-positive, ramificated and filamentous bacteria of the Nocardia genus, subgroup Actinomycetos. The diagnosis is based on the presence of the inflammatory lesions with the morphologically compatible microorganism associated with microbiological and molecular isolation and identification. The objective of this work is to report a case of nocardiosis in a canine that developed peritoneal pyogranulomatous inflammation six months after ovariosalpingohisterectomy. The animal had hyperthermia, abdominal distention, tachypnea, polydipsia, hyporexia, hypocorous mucosae and pasty feces. The laboratory findings revealed mild anemia and leukocytosis due to neutrophilia with left deviation and hypoalbuminemia. A mass in the mesogastric region and peritoneal effusion were evidenced by abdominal ultrasonography. The fluid was classified as pyogranulomatous exudate and the animal underwent exploratory laparotomy for abdominal lavage and mass removal. Despite the therapeutic procedures and clinical alterations the dog died. Piogranulomatous peritonitis was the main anatomopathological alteration which was associated with Nocardia spp. Molecularly, the isolated species approaches the N. concava species through phylogenetic analysis. This specie was described as a cause of infection in humans in Asia; however, there are no records in literature on the canine species, being this the first report.(AU)


Assuntos
Animais , Feminino , Cães , Peritonite/cirurgia , Peritonite/diagnóstico , Peritonite/veterinária , Nocardiose/diagnóstico , Nocardiose/veterinária
6.
Pneumologie ; 73(9): 538-543, 2019 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-31533175

RESUMO

A 47-year-old man presented with fever, weight loss and pulmonary consolidations and cavitation in the x-ray of the thorax. The comprehensive diagnostics resulted pulmonary epitholoid cell granulomas, therefore an immunosuppressive therapy was applied on suspicion of sarcoidosis. Progressivly the pulmonary infiltration increased and cerebral and abdominal abscesses were determined with microbiological detection of Nocardia farcinica. Despite antibiotic therapy, the patient died in a septic shock with multiple organ failure.Nocardiosis is a rare granulomatous bacterial infectious disease. Risk factors include immunosuppression and structural lung diseases. Characteristic is an abscess formation that can occur in any organ, while pulmonary onset is common.The case demonstrates the importance of considering rare differential diagnoses in the detection of pulmonary epithelioid granulomas.


Assuntos
Febre/etiologia , Doença Granulomatosa Crônica/microbiologia , Pulmão/microbiologia , Nocardiose/microbiologia , Diagnóstico Diferencial , Granuloma/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Nocardia , Nocardiose/diagnóstico , Perda de Peso
7.
BMJ Case Rep ; 12(7)2019 Jul 11.
Artigo em Inglês | MEDLINE | ID: mdl-31300597

RESUMO

Central venous catheter-associated bacteraemia caused by Nocardia species is very rare; the diagnosis of nocardiosis in patients with cancer is challenging because its clinical presentation is varied, sometimes mimicking metastases, and the high index of clinical suspicion is required for prompt institution of therapy. Herein, we report a case of nocardial sepsis with native aortic valve endocarditis in a patient with breast cancer in whom multidisciplinary team involvement and prompt initiation of therapy have led to successful outcome.


Assuntos
Valva Aórtica/microbiologia , Neoplasias da Mama/terapia , Cateteres Venosos Centrais/microbiologia , Endocardite Bacteriana/microbiologia , Nocardiose/diagnóstico , Nocardia/isolamento & purificação , Radiografia Torácica , Sepse/microbiologia , Amicacina/uso terapêutico , Antibacterianos/uso terapêutico , Anticoagulantes/uso terapêutico , Valva Aórtica/diagnóstico por imagem , Valva Aórtica/cirurgia , Clopidogrel/uso terapêutico , Tosse , Endocardite Bacteriana/tratamento farmacológico , Endocardite Bacteriana/etiologia , Fadiga , Feminino , Cefaleia , Implante de Prótese de Valva Cardíaca , Humanos , Meropeném/uso terapêutico , Pessoa de Meia-Idade , Nocardiose/patologia , Nocardiose/terapia , Inibidores da Agregação de Plaquetas/uso terapêutico , Sepse/tratamento farmacológico , Resultado do Tratamento , Varfarina/uso terapêutico
9.
Int J Med Sci ; 16(6): 838-844, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31337957

RESUMO

The increased use of novel and powerful immunosuppressive drugs in kidney diseases may concomitantly expose the patients to higher risk of opportunistic infections, some of which still remain underdiagnosed thus mishandled. As such, we recently had a less prepared encounter of pulmonary nocardial infection in an ANCA-associated renal vasculitis patient under steroid therapy. Despite the use of broad-spectrum antimicrobials including micafungin, the infection was still unbridled and eventually culminated in lethal brain abscess. We thus chose to renew the knowledge of the clinical features, imaging manifestations, differential diagnosis, specific laboratory tests and unique treatment about this rare infection in kidney diseases patients under immunosuppressive therapy. In addition, CT images of easily confused pulmonary lesions superimposed on kidney diseases were also retrieved from our depository. Moreover, impaired renal function as a risk factor for infection and pharmacological options for the treatment were also focused. By sharing our hard-learnt experience and reviewing the literatures, our report may contribute to the awareness among the clinicians in general and nephrologists in particular of this rare disease in susceptible patients and facilitate a swift thus life-saving treatment.


Assuntos
Antibacterianos/uso terapêutico , Imunossupressores/efeitos adversos , Nocardiose/diagnóstico , Infecções Oportunistas/diagnóstico , Pneumonia Bacteriana/diagnóstico , Lesão Renal Aguda/complicações , Lesão Renal Aguda/imunologia , Lesão Renal Aguda/terapia , Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/tratamento farmacológico , Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos/imunologia , Encéfalo/diagnóstico por imagem , Encéfalo/microbiologia , Abscesso Encefálico/diagnóstico , Abscesso Encefálico/tratamento farmacológico , Abscesso Encefálico/etiologia , Diagnóstico Diferencial , Feminino , Humanos , Hospedeiro Imunocomprometido , Pulmão/diagnóstico por imagem , Pulmão/microbiologia , Metilprednisolona/efeitos adversos , Pessoa de Meia-Idade , Nocardiose/tratamento farmacológico , Nocardiose/etiologia , Nocardia asteroides/isolamento & purificação , Infecções Oportunistas/tratamento farmacológico , Infecções Oportunistas/etiologia , Plasmaferese , Pneumonia Bacteriana/tratamento farmacológico , Pneumonia Bacteriana/etiologia , Tomografia Computadorizada por Raios X
11.
Clin Lab ; 65(6)2019 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-31232022

RESUMO

BACKGROUND: Invasive pulmonary aspergillosis and nocardia overlap in clinical and radiological presentations, so differentiating between nocardia and invasive pulmonary aspergillosis is confusing. Though sputum culture could distinguish between nocardia and aspergillus fumigatus, but for the ultimate diagnosis, sputum culture provided limited help. Here we report a case of a patient with positive G test and aspergillus fumigatus sputum culture mimic invasive pulmonary aspergillosis ultimately diagnosed as nocardia through bronchoalveolar lavage culture combined metagenomic next-generation sequencing (NGS). METHODS: Bronchoalveolar lavage culture combined metagenomic NGS for infectious diseases were performed for diagnosis. RESULTS: Bronchoalveolar lavage culture combined metagenomic next-generation sequencing showed Nocardia Gelsenkirchen. CONCLUSIONS: Positive G test and sputum culture were not specific, while bronchoalveolar lavage culture and NGS gave more information for a differential diagnosis between nocardia and aspergillus fumigatus.


Assuntos
Aspergillus fumigatus/isolamento & purificação , Aspergilose Pulmonar Invasiva/diagnóstico , Nocardiose/diagnóstico , Nocardia/isolamento & purificação , Escarro/microbiologia , beta-Glucanas/sangue , Aspergillus fumigatus/genética , Aspergillus fumigatus/fisiologia , Líquido da Lavagem Broncoalveolar/microbiologia , Diagnóstico Diferencial , Feminino , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Aspergilose Pulmonar Invasiva/microbiologia , Teste do Limulus , Pulmão/microbiologia , Pessoa de Meia-Idade , Nocardia/genética , Nocardia/fisiologia , Nocardiose/microbiologia , Sensibilidade e Especificidade
12.
Diagn Cytopathol ; 47(9): 935-938, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31173479

RESUMO

Nocardiosis is primarily a pulmonary infection commonly seen in immunocompromised individuals. However, lymphocutaneous nocardiosis is observed in immunocompetent individuals often after trauma. The clinical and cytomorphological features of lymphocutaneous nocardiosis closely mimic the most common infections in India such as tuberculosis and mycetoma (very common cutaneous infection with discharging sinus). As it is crucial to differentiate nocardiosis from tuberculosis, to avoid unnecessary antitubercular treatment, special stains like modified Ziehl-Neelsen stain and Gram stain can be employed to differentiate the morphology of Nocardia from tuberculosis. Fine-needle cytology from these cutaneous lesions helps in yielding adequate material for rapid and accurate diagnosis of immediate specific antibiotic treatment. We report a rare case that presented with clinical diagnosis of tuberculosis but turned out to be nocardiosis on cytomorphology with simple and most feasible fine-needle aspiration method of tissue diagnosis and scrape cytology.


Assuntos
Nocardiose , Nocardia/metabolismo , Tuberculose Cutânea , Adulto , Diagnóstico Diferencial , Feminino , Humanos , Nocardiose/diagnóstico , Nocardiose/metabolismo , Nocardiose/patologia , Tuberculose Cutânea/diagnóstico , Tuberculose Cutânea/metabolismo , Tuberculose Cutânea/patologia
15.
J Coll Physicians Surg Pak ; 29(3): 278-280, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30823959

RESUMO

Nocardia species usually cause opportunistic infections, and the frequency of these infections is increasing owing to the growing population of immunocompromised hosts. However, Nocardia may sometimes causes an infectious disease in immunocompetent hosts. Herein, we report two cases of pulmonary nocardiasis in immunocompetent individuals, whose chest computed tomography (CT) findings mimicked bronchiectasis. Samples of bronchalveolar lavage (BAL) fluid obtained by bronchoscopy showed filamentous, branching, gram-positive rods, acid-fast filamentous branching rods, and a colony of suspected Nocardia was cultured. Based on 16sRNA and hsp65 gene sequence analysis, case 1 was identified as N. cyriacigeorgica, but case 2 was not matched. The patients responded well to treatment with the combination of sulfamethoxazole and linezolid.


Assuntos
Bronquiectasia/diagnóstico por imagem , Linezolida/uso terapêutico , Nocardiose/diagnóstico por imagem , Nocardiose/tratamento farmacológico , Sulfametoxazol/administração & dosagem , Tomografia Computadorizada por Raios X/métodos , Bronquiectasia/diagnóstico , Diagnóstico Diferencial , Quimioterapia Combinada , Feminino , Seguimentos , Humanos , Imunocompetência/imunologia , Masculino , Pessoa de Meia-Idade , Nocardia/efeitos dos fármacos , Nocardia/isolamento & purificação , Nocardiose/diagnóstico , Medição de Risco , Índice de Gravidade de Doença , Resultado do Tratamento
16.
Medicine (Baltimore) ; 98(11): e14879, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30882696

RESUMO

RATIONALE: Nocardia species are not commonly referred as primary infectious entities but rather as opportunistic pathogens. Infectious cases of Nocardia spp. in immunocompetent individuals are rare. PATIENT CONCERNS: An immunocompetent 58-year-old patient presented with recurrent headaches. DIAGNOSIS: A brain abscess was found and surgically drained. Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry and heat shock protein 65/16S-23S rRNA gene intergenic spacer genotyping from the sample revealed the etiological agent as Nocardia beijingensis. INTERVENTIONS: Meropenem/amikacin/Trimethoprim-sulfamethoxazole were administered. OUTCOMES: The infection persisted leading to the patient's death. LESSONS: Here we present the first case of N. beijingensis infection of the central nervous system in an immunocompetent patient from Latin America. Further inquiry is needed to establish whether this species is more virulent than other Nocardia isolates.


Assuntos
Abscesso Encefálico/diagnóstico , Nocardiose/complicações , Antibacterianos/uso terapêutico , Abscesso Encefálico/etiologia , Humanos , América Latina , Masculino , Meropeném/uso terapêutico , Pessoa de Meia-Idade , Nocardia/patogenicidade , Nocardiose/diagnóstico , Tomografia Computadorizada por Raios X/métodos , Combinação Trimetoprima e Sulfametoxazol/uso terapêutico
17.
J Infect Chemother ; 25(7): 552-555, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30852105

RESUMO

Here, we present a case of disseminated nocardiosis, involving pneumonia, percutaneous abscess, and bacteremia, in a 67-year-old Japanese woman. She had also been treated for rheumatoid arthritis with prednisolone, methotrexate, and tocilizumab (interleukin-6 receptor inhibitor). Based on the 16S rRNA sequence analysis and a blast search, we identified the isolate as Nocardia brasiliensis. We discontinued methotrexate and tocilizumab on admission, and administered intravenous antimicrobial combination therapy for 6 weeks, followed by oral trimethoprim-sulfamethoxazole for 12 months, in total. Nocardia bacteremia is rare, often difficult to diagnose, and substantially fatal. However, due to our prompt diagnosis within one day of the onset of symptoms, and administration of appropriate treatment based on antimicrobial susceptibilities, this patient succeeded in surviving the infection. Not only microbiologists but also clinicians should be aware of the characteristic bacterial form of Gram/Kinyoun staining for early recognition of nocardiosis.


Assuntos
Antibacterianos/uso terapêutico , Anticorpos Monoclonais Humanizados/efeitos adversos , Bacteriemia/diagnóstico , Nocardiose/diagnóstico , Nocardia/isolamento & purificação , Idoso , Artrite Reumatoide/tratamento farmacológico , Artrite Reumatoide/imunologia , Bacteriemia/tratamento farmacológico , Bacteriemia/microbiologia , DNA Bacteriano/isolamento & purificação , Quimioterapia Combinada/métodos , Feminino , Violeta Genciana , Humanos , Nocardia/genética , Nocardiose/tratamento farmacológico , Nocardiose/microbiologia , Fenazinas , RNA Ribossômico 16S/genética , Resultado do Tratamento
19.
PLoS One ; 14(2): e0211989, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30802260

RESUMO

BACKGROUND: Transplant recipients are at risk of pulmonary nocardiosis, a life-threatening opportunistic infection caused by Nocardia species. Given the limitations of conventional diagnostic techniques (i.e., microscopy and culture), a polymerase chain reaction (PCR)-based assay was developed to detect Nocardia spp. on clinical samples. While this test is increasingly being used by transplant physicians, its performance characteristics are not well documented. We evaluated the performance characteristics of this test on bronchoalveolar lavage (BAL) fluid samples from lung transplant recipients (LTRs). METHODS: We prospectively included all BAL samples from LTRs undergoing bronchoscopy at our institution between December 2016 and June 2017 (either surveillance or clinically-indicated bronchoscopies). Presence of microbial pathogens was assessed using techniques available locally (including microscopy and 10-day culture for Nocardia). BAL samples were also sent to the French Nocardiosis Observatory (Lyon, France) for the Nocardia PCR-based assay. Transplant physicians and patients were blinded to the Nocardia PCR results. RESULTS: We included 29 BAL samples from 21 patients (18 surveillance and 11 clinically-indicated bronchoscopies). Nocardiosis was not diagnosed in any of these patients by conventional techniques. However, Nocardia PCR was positive in five BAL samples from five of the patients (24%, 95% confidence interval: 11-45%); four were asymptomatic and undergoing surveillance bronchoscopy, and one was symptomatic and was later diagnosed with influenza virus infection. None of the five PCR-positive patients died or were diagnosed with nocardiosis during the median follow-up of 21 months after the index bronchoscopy (range: 20-23 months). CONCLUSIONS: In this prospective study, Nocardia PCR was positive on BAL fluid from one fourth of the LTRs. Nocardia PCR-based assays should be used with caution on respiratory samples from LTRs because of the possible detection of airway colonization using this technique. Larger studies are required to determine the usefulness of the Nocardia PCR-based assay in transplant recipients.


Assuntos
Transplante de Pulmão/efeitos adversos , Nocardiose/diagnóstico , Nocardia/isolamento & purificação , Infecções Oportunistas/microbiologia , Adulto , Idoso , Bélgica , Líquido da Lavagem Broncoalveolar/microbiologia , Feminino , Humanos , Pessoa de Meia-Idade , Nocardia/genética , Projetos Piloto , Reação em Cadeia da Polimerase , Estudos Prospectivos , RNA Ribossômico 16S/genética , RNA Viral/genética , Sensibilidade e Especificidade
20.
Pediatr Pulmonol ; 54(4): E10-E12, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30706673

RESUMO

Nocardia spp is a gram-positive aerobic filamentous bacteria that causes pulmonary and systemic infections, especially in patients with immunosuppression or chronic lung diseases. It is rarely reported in children with cystic fibrosis. Macrophage activation syndrome is a life-threatening disease with an excessive inflammatory response usually triggered by infections. There are few reports in cystic fibrosis related to macrophage activation syndrome. Herein we report a child with cystic fibrosis who had macrophage activation syndrome due to Nocardia infection.


Assuntos
Fibrose Cística/microbiologia , Síndrome de Ativação Macrofágica/diagnóstico , Nocardiose/diagnóstico , Criança , Fibrose Cística/imunologia , Humanos , Síndrome de Ativação Macrofágica/imunologia , Síndrome de Ativação Macrofágica/microbiologia , Masculino , Nocardia , Nocardiose/imunologia , Nocardiose/microbiologia
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